BLASTX 7.6.2
Query= UN00658 /QuerySize=1496
(1495 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase D... 166 4e-040
sp|Q05609|CTR1_ARATH Serine/threonine-protein kinase CTR1 OS=Ara... 159 8e-038
sp|Q54TA1|DRKC_DICDI Probable serine/threonine-protein kinase dr... 151 2e-035
sp|Q02779|M3K10_HUMAN Mitogen-activated protein kinase kinase ki... 149 6e-035
sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase ki... 149 6e-035
sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase ki... 149 8e-035
sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase ki... 149 8e-035
sp|O43283|M3K13_HUMAN Mitogen-activated protein kinase kinase ki... 149 8e-035
sp|Q1HKZ5|M3K13_MOUSE Mitogen-activated protein kinase kinase ki... 149 8e-035
sp|A7J1T2|M313A_XENLA Mitogen-activated protein kinase kinase ki... 148 1e-034
sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase ki... 148 1e-034
sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kina... 148 1e-034
sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kina... 148 1e-034
sp|Q5R8X7|M3K13_PONAB Mitogen-activated protein kinase kinase ki... 148 2e-034
sp|Q55EI8|Y9956_DICDI Probable serine/threonine-protein kinase D... 148 2e-034
sp|Q66L42|M3K10_MOUSE Mitogen-activated protein kinase kinase ki... 147 2e-034
sp|A7MBB4|M3K13_BOVIN Mitogen-activated protein kinase kinase ki... 146 7e-034
sp|A7J1T0|M313B_XENLA Mitogen-activated protein kinase kinase ki... 145 9e-034
sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase kinase kin... 145 9e-034
sp|Q3U1V8|M3K9_MOUSE Mitogen-activated protein kinase kinase kin... 144 1e-033
>sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase DDB_G0267514
OS=Dictyostelium discoideum GN=DDB_G0267514 PE=3 SV=1
Length = 916
Score = 166 bits (420), Expect = 4e-040
Identities = 103/270 (38%), Positives = 152/270 (56%), Gaps = 16/270 (5%)
Frame = +3
Query: 363 IKNDDLEELKELGSGTFGTVYHGKWRGTDVAIKRIKRSCFIGRSSEQDRLTSEFWHEAGI 542
I +L+ +LG GTFG VY G WRG+ VAIK+IK + +++ EF E I
Sbjct: 657 ISFSELKISSKLGEGTFGVVYKGLWRGSSVAIKQIKIN-----EDVNNQVLEEFRKELTI 711
Query: 543 LSKLHHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNR-QIDRRKRLIIAMDAA 719
LS+L HPN++ P L +TEY+ GSL L S + +++ + +A+ A
Sbjct: 712 LSRLRHPNIVLLMAACTAPP--NLCFITEYLPGGSLYDALHSKKIKMNMQLYKKLAIQIA 769
Query: 720 FGMEYLHSKNIVHFDLKCDNLLVNLKDPARPICKVGDFGLSKIK-RNTLVTGGVRGTLPW 896
GM YLH ++H D+K NLL++ K+ DFGLSK+K ++T +T + G+ W
Sbjct: 770 QGMNYLHLSGVIHRDIKSLNLLLD----EHMNVKICDFGLSKLKSKSTEMTKSI-GSPIW 824
Query: 897 MAPELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPSY 1076
M+PELL G +EKVDV++FGI+LWE+ TGE PY+ + + + +LRP +P+
Sbjct: 825 MSPELLMGED--YTEKVDVYAFGIILWELGTGELPYSGLDSVQLALAVTTKSLRPPIPNA 882
Query: 1077 CDPEWRMLMEQCWAPDPFVRPSFPEIARRL 1166
+ L++ CW DP RPSF EI L
Sbjct: 883 WPYQLSHLIQACWHQDPLKRPSFTEILNLL 912
>sp|Q05609|CTR1_ARATH Serine/threonine-protein kinase CTR1 OS=Arabidopsis
thaliana GN=CTR1 PE=1 SV=1
Length = 821
Score = 159 bits (400), Expect = 8e-038
Identities = 93/231 (40%), Positives = 135/231 (58%), Gaps = 14/231 (6%)
Frame = +3
Query: 516 SEFWHEAGILSKLHHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLL---SNRQIDR 686
+EF E I+ +L HPN++ F V P L+ VTEY+ GSL +L + Q+D
Sbjct: 591 NEFLREVAIMKRLRHPNIVLFMGAVTQPP--NLSIVTEYLSRGSLYRLLHKSGAREQLDE 648
Query: 687 RKRLIIAMDAAFGMEYLHSKN--IVHFDLKCDNLLVNLKDPARPICKVGDFGLSKIKRNT 860
R+RL +A D A GM YLH++N IVH DLK NLLV+ K KV DFGLS++K +T
Sbjct: 649 RRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTV----KVCDFGLSRLKAST 704
Query: 861 LVTG-GVRGTLPWMAPELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGG 1037
++ GT WMAPE+L S +EK DV+SFG++LWE+ T ++P+ N++ ++
Sbjct: 705 FLSSKSAAGTPEWMAPEVLRDEPS--NEKSDVYSFGVILWELATLQQPWGNLNPAQVVAA 762
Query: 1038 IVNNTLRPAVPSYCDPEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAV 1190
+ R +P +P+ ++E CW +P+ RPSF I LR + SAV
Sbjct: 763 VGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAV 813
>sp|Q54TA1|DRKC_DICDI Probable serine/threonine-protein kinase drkC
OS=Dictyostelium discoideum GN=drkC PE=3 SV=1
Length = 749
Score = 151 bits (380), Expect = 2e-035
Identities = 106/287 (36%), Positives = 150/287 (52%), Gaps = 26/287 (9%)
Frame = +3
Query: 348 RSLQVIKNDDLEEL---KELGSGTFGTVYHGKWRGTDVAIKRIKRSCFIGRSSEQDRLTS 518
++L IK D+ E+ +G G+ V+ G WRG VAIK+ K + + + +
Sbjct: 478 KTLFEIKPIDISEIVVQNRIGRGSCAEVFTGTWRGIIVAIKKAKL-----LNEDDEDFLN 532
Query: 519 EFWHEAGILSKLHHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLS-NRQIDRRKR 695
E EA I+S+L HPN+ F + P + V EYM GSL +L + +D +
Sbjct: 533 ELAQEATIMSQLRHPNICQFLGTCNNPP--EILIVMEYMPLGSLYRILHDPSISLDWPRM 590
Query: 696 LIIAMDAAFGMEYLHSKN--IVHFDLKCDNLLVNLKDPARPICKVGDFGLS-----KIKR 854
+A+D A GM YLH + ++H DLK NLLV+ K+ DFGLS + +
Sbjct: 591 KSMALDIAKGMNYLHCCDPIVIHRDLKSHNLLVD----EHYRVKISDFGLSTRFKKHLDK 646
Query: 855 NTLVTGGVRGTLPWMAPELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIG 1034
T +T GT W APE+L + +EK DVFSF IVLWEI+T E+PY M I+
Sbjct: 647 KTAMT--PVGTPCWTAPEVL--RNDPYTEKADVFSFAIVLWEIVTREDPYQGMPTFQIVI 702
Query: 1035 GIVNNTLRPAVPSYCDPEWRMLMEQCWAPDPFVRPSFPEIARRLRTM 1175
+ + LRP VP + L+ +CW+ DP RPSF EI +RL M
Sbjct: 703 SVGQHKLRPIVPPQVSAPFTRLITECWSEDPQQRPSFQEIVKRLEAM 749
>sp|Q02779|M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 OS=Homo
sapiens GN=MAP3K10 PE=1 SV=3
Length = 954
Score = 149 bits (375), Expect = 6e-035
Identities = 100/281 (35%), Positives = 143/281 (50%), Gaps = 25/281 (8%)
Frame = +3
Query: 378 LEELKELGSGTFGTVYHGKWRGTDVAIKRIKRSCFIGRSSEQDRLTSEFWHEAGILSKLH 557
LEE+ +G G FG VY WRG +VA+K + + + + EA + L
Sbjct: 100 LEEI--IGVGGFGKVYRALWRGEEVAVKAAR----LDPEKDPAVTAEQVCQEARLFGALQ 153
Query: 558 HPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAFGMEYL 737
HPN++A + P L V EY G+L V L+ R++ + A+ A GM YL
Sbjct: 154 HPNIIALRGACLNPP--HLCLVMEYARGGALSRV-LAGRRVPPHVLVNWAVQVARGMNYL 210
Query: 738 HSK---NIVHFDLKCDNLLV-------NLKDPARPICKVGDFGLSKIKRNTLVTGGVRGT 887
H+ I+H DLK N+L+ NL D + K+ DFGL++ T GT
Sbjct: 211 HNDAPVPIIHRDLKSINILILEAIENHNLAD---TVLKITDFGLAREWHKTTKMSAA-GT 266
Query: 888 LPWMAPELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAV 1067
WMAPE++ S S+ DV+SFG++LWE+LTGE PY + A+ G+ N L +
Sbjct: 267 YAWMAPEVI--RLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPI 324
Query: 1068 PSYCDPEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAV 1190
PS C + L+E+CW PDP RP F I +RL + SA+
Sbjct: 325 PSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSAL 365
>sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 OS=Homo
sapiens GN=MAP3K11 PE=1 SV=1
Length = 847
Score = 149 bits (375), Expect = 6e-035
Identities = 98/288 (34%), Positives = 146/288 (50%), Gaps = 21/288 (7%)
Frame = +3
Query: 378 LEELKELGSGTFGTVYHGKWRGTDVAIKRIKRSCFIGRSSEQDRLTSE-FWHEAGILSKL 554
LEE+ +G G FG VY G WRG VA+K ++ E +T+E EA + + L
Sbjct: 119 LEEV--IGIGGFGKVYRGSWRGELVAVKAARQD-----PDEDISVTAESVRQEARLFAML 171
Query: 555 HHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAFGMEY 734
HPN++A + + P L V EY G L L+ R++ + A+ A GM Y
Sbjct: 172 AHPNIIALKAVCLEEP--NLCLVMEYAAGGPLSRA-LAGRRVPPHVLVNWAVQIARGMHY 228
Query: 735 LHSK---NIVHFDLKCDNLL----VNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTLP 893
LH + ++H DLK +N+L + D K+ DFGL++ T GT
Sbjct: 229 LHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAA-GTYA 287
Query: 894 WMAPELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPS 1073
WMAPE++ S+ S+ DV+SFG++LWE+LTGE PY + A+ G+ N L +PS
Sbjct: 288 WMAPEVIKAST--FSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPS 345
Query: 1074 YCDPEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAVQTKAQAANH 1217
C + LM CWA DP RP F I ++L + + ++ + + H
Sbjct: 346 TCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFH 393
>sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 OS=Homo
sapiens GN=MAP3K12 PE=1 SV=2
Length = 859
Score = 149 bits (374), Expect = 8e-035
Identities = 84/218 (38%), Positives = 119/218 (54%), Gaps = 8/218 (3%)
Frame = +3
Query: 543 LSKLHHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAF 722
L KL HPN++ F + P + E+ G L VL + R + + +M A
Sbjct: 165 LRKLKHPNIITFKGVCTQAP--CYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAG 222
Query: 723 GMEYLHSKNIVHFDLKCDNLLVNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTLPWMA 902
GM YLH I+H DLK N+L+ D + K+ DFG SK + GT+ WMA
Sbjct: 223 GMNYLHLHKIIHRDLKSPNMLITYDD----VVKISDFGTSKELSDKSTKMSFAGTVAWMA 278
Query: 903 PELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPSYCD 1082
PE++ + VSEKVD++SFG+VLWE+LTGE PY ++ AII G+ +N+L VPS C
Sbjct: 279 PEVI--RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCP 336
Query: 1083 PEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAVQT 1196
+++L+ QCW P RPSF +I L S+ + T
Sbjct: 337 DGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLST 374
>sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase kinase 12 OS=Mus
musculus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 149 bits (374), Expect = 8e-035
Identities = 84/218 (38%), Positives = 119/218 (54%), Gaps = 8/218 (3%)
Frame = +3
Query: 543 LSKLHHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAF 722
L KL HPN++ F + P + E+ G L VL + R + + +M A
Sbjct: 198 LRKLKHPNIITFKGVCTQAP--CYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAG 255
Query: 723 GMEYLHSKNIVHFDLKCDNLLVNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTLPWMA 902
GM YLH I+H DLK N+L+ D + K+ DFG SK + GT+ WMA
Sbjct: 256 GMNYLHLHKIIHRDLKSPNMLITYDD----VVKISDFGTSKELSDKSTKMSFAGTVAWMA 311
Query: 903 PELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPSYCD 1082
PE++ + VSEKVD++SFG+VLWE+LTGE PY ++ AII G+ +N+L VPS C
Sbjct: 312 PEVI--RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCP 369
Query: 1083 PEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAVQT 1196
+++L+ QCW P RPSF +I L S+ + T
Sbjct: 370 DGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLST 407
>sp|O43283|M3K13_HUMAN Mitogen-activated protein kinase kinase kinase 13 OS=Homo
sapiens GN=MAP3K13 PE=1 SV=1
Length = 966
Score = 149 bits (374), Expect = 8e-035
Identities = 87/218 (39%), Positives = 120/218 (55%), Gaps = 8/218 (3%)
Frame = +3
Query: 543 LSKLHHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAF 722
L KL HPN++AF + P + EY +G L VL + R+I R + + A
Sbjct: 208 LRKLKHPNIIAFKGVCTQAP--CYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIAS 265
Query: 723 GMEYLHSKNIVHFDLKCDNLLVNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTLPWMA 902
GM YLH I+H DLK N+LV D K+ DFG SK + GT+ WMA
Sbjct: 266 GMNYLHLHKIIHRDLKSPNVLVTHTDAV----KISDFGTSKELSDKSTKMSFAGTVAWMA 321
Query: 903 PELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPSYCD 1082
PE++ + VSEKVD++SFG+VLWE+LTGE PY ++ AII G+ +N+L VPS C
Sbjct: 322 PEVI--RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCP 379
Query: 1083 PEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAVQT 1196
+++LM+Q W P RPSF + L S+ + T
Sbjct: 380 DGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLAT 417
>sp|Q1HKZ5|M3K13_MOUSE Mitogen-activated protein kinase kinase kinase 13 OS=Mus
musculus GN=Map3k13 PE=2 SV=1
Length = 959
Score = 149 bits (374), Expect = 8e-035
Identities = 87/218 (39%), Positives = 120/218 (55%), Gaps = 8/218 (3%)
Frame = +3
Query: 543 LSKLHHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAF 722
L KL HPN++AF + P + EY +G L VL + R+I R + + A
Sbjct: 207 LRKLKHPNIIAFKGVCTQAP--CYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIAS 264
Query: 723 GMEYLHSKNIVHFDLKCDNLLVNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTLPWMA 902
GM YLH I+H DLK N+LV D K+ DFG SK + GT+ WMA
Sbjct: 265 GMNYLHLHKIIHRDLKSPNVLVTHTDAV----KISDFGTSKELSDKSTKMSFAGTVAWMA 320
Query: 903 PELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPSYCD 1082
PE++ + VSEKVD++SFG+VLWE+LTGE PY ++ AII G+ +N+L VPS C
Sbjct: 321 PEVI--RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCP 378
Query: 1083 PEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAVQT 1196
+++LM+Q W P RPSF + L S+ + T
Sbjct: 379 DGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLAT 416
>sp|A7J1T2|M313A_XENLA Mitogen-activated protein kinase kinase kinase 13-A
OS=Xenopus laevis GN=map3k13-a PE=2 SV=1
Length = 961
Score = 148 bits (373), Expect = 1e-034
Identities = 86/218 (39%), Positives = 121/218 (55%), Gaps = 8/218 (3%)
Frame = +3
Query: 543 LSKLHHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAF 722
L KL HPN++AF + P + EY +G L VL + R++ R + + A
Sbjct: 209 LRKLKHPNIIAFKGVCTQAP--CYCLIMEYCAHGQLYEVLRAGRKVSPRLLVDWSNGIAS 266
Query: 723 GMEYLHSKNIVHFDLKCDNLLVNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTLPWMA 902
GM YLH I+H DLK N+LV D K+ DFG SK + GT+ WMA
Sbjct: 267 GMNYLHLHKIIHRDLKSPNVLVTHTDTV----KISDFGTSKELSDKSTKMSFAGTVAWMA 322
Query: 903 PELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPSYCD 1082
PE++ + VSEKVD++SFG++LWE+LTGE PY ++ AII G+ +N+L VPS C
Sbjct: 323 PEVI--RNEPVSEKVDIWSFGVLLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCP 380
Query: 1083 PEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAVQT 1196
+++LM+Q W P RPSF +I L S+ + T
Sbjct: 381 DGFKILMKQTWHSKPRNRPSFRQILMHLDIASADVLGT 418
>sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase kinase 11 OS=Mus
musculus GN=Map3k11 PE=1 SV=1
Length = 850
Score = 148 bits (373), Expect = 1e-034
Identities = 98/288 (34%), Positives = 146/288 (50%), Gaps = 21/288 (7%)
Frame = +3
Query: 378 LEELKELGSGTFGTVYHGKWRGTDVAIKRIKRSCFIGRSSEQDRLTSE-FWHEAGILSKL 554
LEE+ +G G FG VY G WRG VA+K ++ E +T+E EA + + L
Sbjct: 120 LEEV--IGIGGFGKVYRGSWRGELVAVKAARQD-----PDEDISVTAESVRQEARLFAML 172
Query: 555 HHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAFGMEY 734
HPN++A + + P L V EY G L L+ R++ + A+ A GM Y
Sbjct: 173 AHPNIIALKAVCLEEP--NLCLVMEYAAGGPLSRA-LAGRRVPPHVLVNWAVQIARGMHY 229
Query: 735 LHSK---NIVHFDLKCDNLL----VNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTLP 893
LH + ++H DLK +N+L + D K+ DFGL++ T GT
Sbjct: 230 LHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAA-GTYA 288
Query: 894 WMAPELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPS 1073
WMAPE++ S+ S+ DV+SFG++LWE+LTGE PY + A+ G+ N L +PS
Sbjct: 289 WMAPEVIKAST--FSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPS 346
Query: 1074 YCDPEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAVQTKAQAANH 1217
C + LM CWA DP RP F I ++L + + ++ + + H
Sbjct: 347 TCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFH 394
>sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kinase 11 OS=Rattus
norvegicus GN=Map3k11 PE=2 SV=1
Length = 850
Score = 148 bits (373), Expect = 1e-034
Identities = 98/288 (34%), Positives = 146/288 (50%), Gaps = 21/288 (7%)
Frame = +3
Query: 378 LEELKELGSGTFGTVYHGKWRGTDVAIKRIKRSCFIGRSSEQDRLTSE-FWHEAGILSKL 554
LEE+ +G G FG VY G WRG VA+K ++ E +T+E EA + + L
Sbjct: 120 LEEV--IGIGGFGKVYRGSWRGELVAVKAARQD-----PDEDISVTAESVRQEARLFAML 172
Query: 555 HHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAFGMEY 734
HPN++A + + P L V EY G L L+ R++ + A+ A GM Y
Sbjct: 173 AHPNIIALKAVCLEEP--NLCLVMEYAAGGPLSRA-LAGRRVPPHVLVNWAVQIARGMHY 229
Query: 735 LHSK---NIVHFDLKCDNLL----VNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTLP 893
LH + ++H DLK +N+L + D K+ DFGL++ T GT
Sbjct: 230 LHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAA-GTYA 288
Query: 894 WMAPELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPS 1073
WMAPE++ S+ S+ DV+SFG++LWE+LTGE PY + A+ G+ N L +PS
Sbjct: 289 WMAPEVIKAST--FSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPS 346
Query: 1074 YCDPEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAVQTKAQAANH 1217
C + LM CWA DP RP F I ++L + + ++ + + H
Sbjct: 347 TCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFH 394
>sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kinase 12 OS=Rattus
norvegicus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 148 bits (373), Expect = 1e-034
Identities = 84/218 (38%), Positives = 119/218 (54%), Gaps = 8/218 (3%)
Frame = +3
Query: 543 LSKLHHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAF 722
L KL HPN++ F + P + E+ G L VL + R + + +M A
Sbjct: 198 LRKLKHPNIITFKGVCTQAP--CYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAG 255
Query: 723 GMEYLHSKNIVHFDLKCDNLLVNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTLPWMA 902
GM YLH I+H DLK N+L+ D + K+ DFG SK + GT+ WMA
Sbjct: 256 GMNYLHLHKIIHRDLKSPNMLITYDD----VVKISDFGTSKELSDKSTKMSFAGTVAWMA 311
Query: 903 PELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPSYCD 1082
PE++ + VSEKVD++SFG+VLWE+LTGE PY ++ AII G+ +N+L VPS C
Sbjct: 312 PEVI--RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCP 369
Query: 1083 PEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAVQT 1196
+++L+ QCW P RPSF +I L S+ + T
Sbjct: 370 DGFKILLRQCWNRKPRNRPSFRQILLHLDIASADVLST 407
>sp|Q5R8X7|M3K13_PONAB Mitogen-activated protein kinase kinase kinase 13
OS=Pongo abelii GN=MAP3K13 PE=2 SV=1
Length = 966
Score = 148 bits (371), Expect = 2e-034
Identities = 86/218 (39%), Positives = 120/218 (55%), Gaps = 8/218 (3%)
Frame = +3
Query: 543 LSKLHHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAF 722
L KL HPN++AF + P + EY +G L VL + R+I R + + A
Sbjct: 208 LRKLKHPNIIAFKGVCTQAP--CYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIAS 265
Query: 723 GMEYLHSKNIVHFDLKCDNLLVNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTLPWMA 902
GM YLH I+H DLK N+LV D K+ DFG SK + GT+ W+A
Sbjct: 266 GMNYLHLHKIIHRDLKSPNVLVTHTDAV----KISDFGTSKELSDKSTKMSFAGTVAWLA 321
Query: 903 PELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPSYCD 1082
PE++ + VSEKVD++SFG+VLWE+LTGE PY ++ AII G+ +N+L VPS C
Sbjct: 322 PEVI--RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCP 379
Query: 1083 PEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAVQT 1196
+++LM+Q W P RPSF + L S+ + T
Sbjct: 380 DGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLAT 417
>sp|Q55EI8|Y9956_DICDI Probable serine/threonine-protein kinase DDB_G0268876
OS=Dictyostelium discoideum GN=DDB_G0268876 PE=3 SV=1
Length = 1385
Score = 148 bits (371), Expect = 2e-034
Identities = 95/275 (34%), Positives = 142/275 (51%), Gaps = 17/275 (6%)
Frame = +3
Query: 354 LQVIKNDDLEELKELGSGTFGTVYHGKWRGTDVAIKRIKRSCFIGRSSEQDRLTSEFWHE 533
L+ I DLE KE+G G G V GKW+G ++A+K+ E EF E
Sbjct: 750 LKYISQSDLELTKEIGRGVSGVVKRGKWKGYEIAVKQF-------NEEELGFSEREFHSE 802
Query: 534 AGILSKLHHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLI-IAM 710
A I+S L H N++ + + G + V +Y GSL V+ +N R++ +A+
Sbjct: 803 ATIMSVLRHDNIV--HCVGGSAQPGKMYLVCDYYSRGSLYSVITANICPLSNARIVHLAL 860
Query: 711 DAAFGMEYLHSKNIVHFDLKCDNLLVNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTL 890
A GM YLHS I+H DLK NLL++ R + DFGLS++ N + GT
Sbjct: 861 QVAKGMNYLHSLGIIHRDLKPGNLLIDQDWNIR----ISDFGLSRVVDNRMTK--TVGTP 914
Query: 891 PWMAPELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVP 1070
+MA E+L G + S++ DV+SF VLWE ++ + PY + I ++ ++ RP +P
Sbjct: 915 CYMAVEVLKGLTD-YSQQADVYSFAFVLWECISRQIPYKDFAQIQWISMVLEDSFRPPIP 973
Query: 1071 SYCDPEWRMLMEQCWAPDPFVRPSFPEIARRLRTM 1175
C PE+R L+ CW +P RPSF +I L +
Sbjct: 974 DSCLPEFRDLITMCWTSNPDDRPSFQQIITYLENL 1008
>sp|Q66L42|M3K10_MOUSE Mitogen-activated protein kinase kinase kinase 10 OS=Mus
musculus GN=Map3k10 PE=2 SV=2
Length = 940
Score = 147 bits (370), Expect = 2e-034
Identities = 99/281 (35%), Positives = 142/281 (50%), Gaps = 25/281 (8%)
Frame = +3
Query: 378 LEELKELGSGTFGTVYHGKWRGTDVAIKRIKRSCFIGRSSEQDRLTSEFWHEAGILSKLH 557
LEE+ +G G FG VY WRG +VA+K + + + + EA + L
Sbjct: 100 LEEI--IGVGGFGKVYRAVWRGEEVAVKAAR----LDPERDPAVTAEQVRQEARLFGALQ 153
Query: 558 HPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAFGMEYL 737
HPN++A P L V EY G+L V L+ R++ + A+ A GM YL
Sbjct: 154 HPNIIALRGACLSPP--NLCLVMEYARGGALSRV-LAGRRVPPHVLVNWAVQVARGMNYL 210
Query: 738 HSK---NIVHFDLKCDNLLV-------NLKDPARPICKVGDFGLSKIKRNTLVTGGVRGT 887
H+ I+H DLK N+L+ NL D + K+ DFGL++ T GT
Sbjct: 211 HNDAPVPIIHRDLKSINILILEAIENHNLAD---TVLKITDFGLAREWHKTTKMSAA-GT 266
Query: 888 LPWMAPELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAV 1067
WMAPE++ S S+ DV+SFG++LWE+LTGE PY + A+ G+ N L +
Sbjct: 267 YAWMAPEVI--RLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPI 324
Query: 1068 PSYCDPEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAV 1190
PS C + L+E+CW PDP RP F I ++L + SA+
Sbjct: 325 PSTCPEPFARLLEECWDPDPHGRPDFGSILKQLEVIEQSAL 365
>sp|A7MBB4|M3K13_BOVIN Mitogen-activated protein kinase kinase kinase 13 OS=Bos
taurus GN=MAP3K13 PE=2 SV=1
Length = 966
Score = 146 bits (366), Expect = 7e-034
Identities = 86/218 (39%), Positives = 119/218 (54%), Gaps = 8/218 (3%)
Frame = +3
Query: 543 LSKLHHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAF 722
L KL HPN++AF + P + EY +G L VL + R+I R + + A
Sbjct: 208 LRKLKHPNIIAFKGVCTQAP--CYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIAS 265
Query: 723 GMEYLHSKNIVHFDLKCDNLLVNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTLPWMA 902
GM YLH I+H DLK N+LV D K+ DFG SK + GT+ WMA
Sbjct: 266 GMNYLHLHKIIHRDLKSPNVLVTHTDAV----KISDFGTSKELSDKSTKMSFAGTVAWMA 321
Query: 903 PELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPSYCD 1082
PE++ + VSEKVD++SFG+VLWE+LTGE PY ++ AII G+ +N+L VPS C
Sbjct: 322 PEVI--RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCP 379
Query: 1083 PEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAVQT 1196
+++LM+Q W RPSF + L S+ + T
Sbjct: 380 DGFKILMKQTWQSKTRNRPSFRQTLMHLDIASADVLAT 417
>sp|A7J1T0|M313B_XENLA Mitogen-activated protein kinase kinase kinase 13-B
OS=Xenopus laevis GN=map3k13-b PE=2 SV=1
Length = 961
Score = 145 bits (365), Expect = 9e-034
Identities = 84/218 (38%), Positives = 120/218 (55%), Gaps = 8/218 (3%)
Frame = +3
Query: 543 LSKLHHPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAF 722
L KL HPN++AF + P + EY G L VL + R++ + + + A
Sbjct: 211 LRKLKHPNIIAFKGVCTQAP--CYCILMEYCAQGQLYEVLRAGRKVTPKLLVEWSTGIAS 268
Query: 723 GMEYLHSKNIVHFDLKCDNLLVNLKDPARPICKVGDFGLSKIKRNTLVTGGVRGTLPWMA 902
GM YLH I+H DLK N+LV D K+ DFG SK + GT+ WMA
Sbjct: 269 GMNYLHLHKIIHRDLKSPNVLVTHADTV----KISDFGTSKELSDKSTKMSFAGTVAWMA 324
Query: 903 PELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPSYCD 1082
PE++ + VSEKVD++SFG++LWE+LTGE PY ++ AII G+ +N+L VPS C
Sbjct: 325 PEVI--RNEPVSEKVDIWSFGVLLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCP 382
Query: 1083 PEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSSAVQT 1196
+++LM+Q W P RPSF +I L ++ + T
Sbjct: 383 DGFKILMKQTWQSKPRNRPSFRQILMHLDIAAADVLGT 420
>sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 OS=Homo
sapiens GN=MAP3K9 PE=1 SV=3
Length = 1104
Score = 145 bits (365), Expect = 9e-034
Identities = 99/276 (35%), Positives = 140/276 (50%), Gaps = 19/276 (6%)
Frame = +3
Query: 378 LEELKELGSGTFGTVYHGKWRGTDVAIKRIKRSCFIGRSSEQDRLTSEFWHEAGILSKLH 557
LEE+ +G G FG VY W G +VA+K + + + EA + + L
Sbjct: 146 LEEI--IGIGGFGKVYRAFWIGDEVAVKAARHD----PDEDISQTIENVRQEAKLFAMLK 199
Query: 558 HPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAFGMEYL 737
HPN++A + P L V E+ G L V LS ++I + A+ A GM YL
Sbjct: 200 HPNIIALRGVCLKEP--NLCLVMEFARGGPLNRV-LSGKRIPPDILVNWAVQIARGMNYL 256
Query: 738 HSKNIV---HFDLKCDNLLVNLK----DPARPICKVGDFGLSKIKRNTLVTGGVRGTLPW 896
H + IV H DLK N+L+ K D + I K+ DFGL++ T GT W
Sbjct: 257 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAA-GTYAW 315
Query: 897 MAPELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPSY 1076
MAPE++ +S S+ DV+S+G++LWE+LTGE P+ + A+ G+ N L +PS
Sbjct: 316 MAPEVI--RASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPST 373
Query: 1077 CDPEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSS 1184
C + LME CW PDP RPSF I +L T+ S
Sbjct: 374 CPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEES 409
>sp|Q3U1V8|M3K9_MOUSE Mitogen-activated protein kinase kinase kinase 9 OS=Mus
musculus GN=Map3k9 PE=2 SV=1
Length = 1077
Score = 144 bits (363), Expect = 1e-033
Identities = 98/276 (35%), Positives = 140/276 (50%), Gaps = 19/276 (6%)
Frame = +3
Query: 378 LEELKELGSGTFGTVYHGKWRGTDVAIKRIKRSCFIGRSSEQDRLTSEFWHEAGILSKLH 557
LEE+ +G G FG VY W G +VA+K + + + EA + + L
Sbjct: 139 LEEI--IGIGGFGKVYRAFWAGDEVAVKAARHD----PDEDISQTIENVRQEAKLFAMLK 192
Query: 558 HPNVMAFYVIVKDGPGGTLATVTEYMVNGSLRHVLLSNRQIDRRKRLIIAMDAAFGMEYL 737
HPN++A + P L V E+ G L V LS ++I + A+ A GM YL
Sbjct: 193 HPNIIALRGVCLKEP--NLCLVMEFARGGPLNRV-LSGKRIPPDILVNWAVQIARGMNYL 249
Query: 738 HSKNIV---HFDLKCDNLLVNLK----DPARPICKVGDFGLSKIKRNTLVTGGVRGTLPW 896
H + IV H DLK N+L+ K D + I ++ DFGL++ T GT W
Sbjct: 250 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILEITDFGLAREWHRTTKMSAA-GTYAW 308
Query: 897 MAPELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVNNTLRPAVPSY 1076
MAPE++ +S S+ DV+S+G++LWE+LTGE P+ + A+ G+ N L +PS
Sbjct: 309 MAPEVI--RASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPST 366
Query: 1077 CDPEWRMLMEQCWAPDPFVRPSFPEIARRLRTMSSS 1184
C + LME CW PDP RPSF I +L T+ S
Sbjct: 367 CPEPFAKLMEDCWNPDPHSRPSFTSILDQLTTIEES 402
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 3,154,264,487
Number of Sequences: 518415
Number of Extensions: 3154264487
Number of Successful Extensions: 47263005
Number of sequences better than 0.0: 0
|
