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SwissProt blast output of UN00725


BLASTX 7.6.2

Query= UN00725 /QuerySize=822
        (821 letters)

Database: UniProt/SwissProt;
          518,415 sequences; 182,829,261 total letters
                                                                  Score    E
Sequences producing significant alignments:                       (bits) Value

sp|P54873|HMCS_ARATH Hydroxymethylglutaryl-CoA synthase OS=Arabi...    449   1e-125
sp|Q5R7Z9|HMCS1_PONAB Hydroxymethylglutaryl-CoA synthase, cytopl...    305   4e-082
sp|Q01581|HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthase, cytopl...    302   2e-081
sp|P23228|HMCS1_CHICK Hydroxymethylglutaryl-CoA synthase, cytopl...    299   2e-080
sp|Q8JZK9|HMCS1_MOUSE Hydroxymethylglutaryl-CoA synthase, cytopl...    299   3e-080
sp|P54872|HMCSA_DICDI Hydroxymethylglutaryl-CoA synthase A OS=Di...    299   3e-080
sp|P17425|HMCS1_RAT Hydroxymethylglutaryl-CoA synthase, cytoplas...    297   6e-080
sp|P13704|HMCS1_CRIGR Hydroxymethylglutaryl-CoA synthase, cytopl...    297   1e-079
sp|P54868|HMCS2_HUMAN Hydroxymethylglutaryl-CoA synthase, mitoch...    291   4e-078
sp|P54869|HMCS2_MOUSE Hydroxymethylglutaryl-CoA synthase, mitoch...    289   3e-077
sp|P22791|HMCS2_RAT Hydroxymethylglutaryl-CoA synthase, mitochon...    285   2e-076
sp|Q2KIE6|HMCS2_BOVIN Hydroxymethylglutaryl-CoA synthase, mitoch...    284   7e-076
sp|P54961|HMCS1_BLAGE Hydroxymethylglutaryl-CoA synthase 1 OS=Bl...    282   3e-075
sp|Q86HL5|HMCSB_DICDI Hydroxymethylglutaryl-CoA synthase B OS=Di...    278   3e-074
sp|O02734|HMCS2_PIG Hydroxymethylglutaryl-CoA synthase, mitochon...    278   5e-074
sp|P54839|HMCS_YEAST Hydroxymethylglutaryl-CoA synthase OS=Sacch...    272   3e-072
sp|P54870|HMCS2_BLAGE Hydroxymethylglutaryl-CoA synthase 2 OS=Bl...    272   4e-072
sp|P54874|HMCS_SCHPO Hydroxymethylglutaryl-CoA synthase OS=Schiz...    261   5e-069
sp|P54871|HMCS_CAEEL Hydroxymethylglutaryl-CoA synthase OS=Caeno...    208   5e-053

>sp|P54873|HMCS_ARATH Hydroxymethylglutaryl-CoA synthase OS=Arabidopsis thaliana
        GN=HMGS PE=2 SV=2

          Length = 461

 Score =  449 bits (1154), Expect = 1e-125
 Identities = 217/234 (92%), Positives = 222/234 (94%)
 Frame = +2

Query: 107 MAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNA 286
           MA++VGILAMDIYFPPTCVQQEALEAHDGASKGKY IGLGQDCLAFCTELEDVISMSFNA
Sbjct:   1 MAKNVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNA 60

Query: 287 VTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGG 466
           VTSL EKYKIDP QIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGG
Sbjct:  61 VTSLFEKYKIDPNQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGG 120

Query: 467 TAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESK 646
           TA LLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAI+MLIGP+APIVFESK
Sbjct: 121 TAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPDAPIVFESK 180

Query: 647 LRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLRNSKAK 808
           LR SHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLC      + K
Sbjct: 181 LRASHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKIEGK 234

>sp|Q5R7Z9|HMCS1_PONAB Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Pongo
        abelii GN=HMGCS1 PE=2 SV=1

          Length = 520

 Score =  305 bits (779), Expect = 4e-082
 Identities = 140/227 (61%), Positives = 175/227 (77%)
 Frame = +2

Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
           +DVGI+A++IYFP   V Q  LE +DG + GKY IGLGQ  + FCT+ ED+ S+    V 
Sbjct:  15 KDVGIVALEIYFPSQYVDQAELEKYDGVAAGKYTIGLGQAKMGFCTDREDINSLCMTVVQ 74

Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
           +L+E+  +    IGRLEVG+ET+IDKSKS+KT LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct:  75 NLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTA 134

Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
            + N VNW+ES+SWDGRY LV+  D AVYA G ARPTGG  A+++LIGPNAP++FE  LR
Sbjct: 135 AVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLR 194

Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLR 793
           G+HM H YDFYKP++ SEYP+VDGKLS  CYL ALD CY   CK +R
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIR 241

>sp|Q01581|HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Homo
        sapiens GN=HMGCS1 PE=1 SV=2

          Length = 520

 Score =  302 bits (773), Expect = 2e-081
 Identities = 139/226 (61%), Positives = 173/226 (76%)
 Frame = +2

Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
           +DVGI+A++IYFP   V Q  LE +DG   GKY IGLGQ  + FCT+ ED+ S+    V 
Sbjct:  15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQ 74

Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
           +L+E+  +    IGRLEVG+ET+IDKSKS+KT LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct:  75 NLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTA 134

Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
            + N VNW+ES+SWDGRY LV+  D AVYA G ARPTGG  A+++LIGPNAP++FE  LR
Sbjct: 135 AVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLR 194

Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSL 790
           G+HM H YDFYKP++ SEYP+VDGKLS  CYL ALD CY   CK +
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI 240

>sp|P23228|HMCS1_CHICK Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Gallus
        gallus GN=HMGCS1 PE=1 SV=1

          Length = 522

 Score =  299 bits (764), Expect = 2e-080
 Identities = 139/223 (62%), Positives = 170/223 (76%)
 Frame = +2

Query: 101 STMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSF 280
           S   +DVGI+A++IYFP   V Q  LE +DG   GKY IGLGQ  + FC++ ED+ S+  
Sbjct:  11 SCWPKDVGIVALEIYFPSQYVDQTELEKYDGVDAGKYTIGLGQSKMGFCSDREDINSLCL 70

Query: 281 NAVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACY 460
             V  L+E+  +    IGRLEVG+ET+IDKSKS+KT LMQLFE+ GNTDVEG+D+TNACY
Sbjct:  71 TVVQKLMERNSLSYDCIGRLEVGTETIIDKSKSVKTVLMQLFEESGNTDVEGIDTTNACY 130

Query: 461 GGTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFE 640
           GGTA L N +NW+ES+SWDGRY LV+  D AVYA G ARPTGGA A++ML+G NAP++FE
Sbjct: 131 GGTAALFNAINWIESSSWDGRYALVVAGDIAVYATGNARPTGGAGAVAMLVGSNAPLIFE 190

Query: 641 SKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCY 769
             LRG+HM H YDFYKP++ SEYPVVDGKLS  CYL ALD CY
Sbjct: 191 RGLRGTHMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALDRCY 233

>sp|Q8JZK9|HMCS1_MOUSE Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Mus
        musculus GN=Hmgcs1 PE=1 SV=1

          Length = 520

 Score =  299 bits (763), Expect = 3e-080
 Identities = 138/227 (60%), Positives = 173/227 (76%)
 Frame = +2

Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
           +DVGI+A++IYFP   V Q  LE +DG   GKY IGLGQ  + FCT+ ED+ S+    V 
Sbjct:  15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQ 74

Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
            L+E++ +    IGRLEVG+ET+IDKSKS+K+ LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct:  75 KLMERHSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTA 134

Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
            + N VNWVES+SWDGRY LV+  D A+YA G ARPTGG  A+++LIGPNAP++F+  LR
Sbjct: 135 AVFNAVNWVESSSWDGRYALVVAGDIAIYATGNARPTGGVGAVALLIGPNAPLIFDRGLR 194

Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLR 793
           G+HM H YDFYKP++ SEYPVVDGKLS  CYL ALD CY    K +R
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIR 241

>sp|P54872|HMCSA_DICDI Hydroxymethylglutaryl-CoA synthase A OS=Dictyostelium
        discoideum GN=hgsA PE=1 SV=2

          Length = 482

 Score =  299 bits (763), Expect = 3e-080
 Identities = 138/236 (58%), Positives = 176/236 (74%)
 Frame = +2

Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
           T  E++GI  +++YFP T V QE LE  DG S+GKY +GLGQ  +AFC + ED+ S+S N
Sbjct:   2 TKPENIGIHGIEVYFPSTYVAQEDLEKFDGVSQGKYTLGLGQTNMAFCGDREDIYSLSLN 61

Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
           AV +L++K+ +DP  IGRLEVG+ETVIDKSKS+KT LM LF K GNT ++G+D+ NACYG
Sbjct:  62 AVNNLMDKFNVDPNSIGRLEVGTETVIDKSKSVKTVLMDLFAKHGNTSIDGIDTINACYG 121

Query: 464 GTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFES 643
           GT+ L N + W+ES+ WDGR  +V+  D AVY +GPARPTGGA  ++MLIGPNAPI FES
Sbjct: 122 GTSALHNALQWMESSYWDGRNAIVVAGDIAVYEKGPARPTGGAGVVAMLIGPNAPITFES 181

Query: 644 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLRNSKAKS 811
            LRG HM +VYDFYKP++ SEYP VDGKLS +CY  A+D+CY    K+      KS
Sbjct: 182 GLRGVHMENVYDFYKPDMDSEYPRVDGKLSISCYFRAIDNCYNRYAKAFEKKYGKS 237

>sp|P17425|HMCS1_RAT Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Rattus
        norvegicus GN=Hmgcs1 PE=1 SV=1

          Length = 520

 Score =  297 bits (760), Expect = 6e-080
 Identities = 137/227 (60%), Positives = 172/227 (75%)
 Frame = +2

Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
           +DVGI+A++IYFP   V Q  LE +DG   GKY IGLGQ  + FCT+ ED+ S+    V 
Sbjct:  15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQ 74

Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
            L+E+  +    IGRLEVG+ET+IDKSKS+K+ LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct:  75 KLMERNSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTA 134

Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
            + N VNW+ES+SWDGRY LV+  D A+YA G ARPTGG  A+++LIGPNAP++F+  LR
Sbjct: 135 AVFNAVNWIESSSWDGRYALVVAGDIAIYASGNARPTGGVGAVALLIGPNAPVIFDRGLR 194

Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLR 793
           G+HM H YDFYKP++ SEYPVVDGKLS  CYL ALD CY    K +R
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIR 241

>sp|P13704|HMCS1_CRIGR Hydroxymethylglutaryl-CoA synthase, cytoplasmic
        OS=Cricetulus griseus GN=HMGCS1 PE=3 SV=1

          Length = 520

 Score =  297 bits (758), Expect = 1e-079
 Identities = 136/227 (59%), Positives = 173/227 (76%)
 Frame = +2

Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
           +DVGI+A++IYFP   V Q  LE +DG   GKY IGLGQ  + FCT+ ED+ S+    V 
Sbjct:  15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQ 74

Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
           +L+E+  +    IGRLEVG+ET+IDKSKS+K+ LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct:  75 NLMERNSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTA 134

Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
            + N VNW+ES+SWDGRY LV+  D A+YA G ARPTGG  A+++LIGPNAP++F+  LR
Sbjct: 135 AVFNAVNWIESSSWDGRYALVVAGDIAIYATGNARPTGGVGAVALLIGPNAPLIFDRGLR 194

Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLR 793
           G+HM H YDFYKP++ SEYP+VDGKLS  CYL ALD CY    K +R
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYRKKIR 241

>sp|P54868|HMCS2_HUMAN Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Homo
        sapiens GN=HMGCS2 PE=1 SV=1

          Length = 508

 Score =  291 bits (744), Expect = 4e-078
 Identities = 134/231 (58%), Positives = 171/231 (74%)
 Frame = +2

Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
           T  +DVGILA+++YFP   V Q  LE ++    GKY +GLGQ  + FC+  ED+ S+   
Sbjct:  49 TWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLT 108

Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
            V  L+E+ ++    +GRLEVG+ET+IDKSK++KT LM+LF+  GNTD+EG+D+TNACYG
Sbjct: 109 VVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYG 168

Query: 464 GTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFES 643
           GTA L N  NW+ES+SWDGRY +V+C D AVY  G ARPTGGA A++MLIGP AP+  E 
Sbjct: 169 GTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALER 228

Query: 644 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLRN 796
            LRG+HM +VYDFYKPNLASEYP+VDGKLS  CYL ALD CY    K ++N
Sbjct: 229 GLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQN 279

>sp|P54869|HMCS2_MOUSE Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Mus
        musculus GN=Hmgcs2 PE=1 SV=2

          Length = 508

 Score =  289 bits (737), Expect = 3e-077
 Identities = 135/231 (58%), Positives = 169/231 (73%)
 Frame = +2

Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
           T  +DVGILA+++YFP   V Q  LE  +    GKY +GLGQ  + FC+  ED+ S+   
Sbjct:  49 TWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLT 108

Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
            V  L+E+ K+    +GRLEVG+ET+IDKSK++KT LM+LF+  GNTD+EG+D+TNACYG
Sbjct: 109 VVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYG 168

Query: 464 GTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFES 643
           GTA L N  NW+ES+ WDGRY LV+C D AVY  G ARPTGGA A++MLIGP AP+V E 
Sbjct: 169 GTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQ 228

Query: 644 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLRN 796
            LRG+HM + YDFYKPNLASEYP+VDGKLS  CYL ALD CY    K ++N
Sbjct: 229 GLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRKKIQN 279

>sp|P22791|HMCS2_RAT Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Rattus
        norvegicus GN=Hmgcs2 PE=2 SV=1

          Length = 508

 Score =  285 bits (729), Expect = 2e-076
 Identities = 133/231 (57%), Positives = 168/231 (72%)
 Frame = +2

Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
           T  +DVGILA+++YFP   V Q  LE  +    GKY +GLGQ  + FC+  ED+ S+   
Sbjct:  49 TWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLT 108

Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
            V  L+E+ K+    +GRLEVG+ET+IDKSK++KT LM+LF+  GNTD+EG+D+TNACYG
Sbjct: 109 VVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYG 168

Query: 464 GTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFES 643
           GTA L N  NW+ES+ WDGRY LV+C D AVY  G  RPTGGA A++MLIGP AP+V E 
Sbjct: 169 GTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNPRPTGGAGAVAMLIGPKAPLVLEQ 228

Query: 644 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLRN 796
            LRG+HM + YDFYKPNLASEYP+VDGKLS  CYL ALD CY    + ++N
Sbjct: 229 GLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRRKIQN 279

>sp|Q2KIE6|HMCS2_BOVIN Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Bos
        taurus GN=HMGCS2 PE=2 SV=1

          Length = 508

 Score =  284 bits (725), Expect = 7e-076
 Identities = 131/222 (59%), Positives = 166/222 (74%)
 Frame = +2

Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
           T  +DVGILAM++YFP   V Q  LE  +    G+Y +GLGQ  + FC+  EDV S+   
Sbjct:  49 TWPKDVGILAMEVYFPAQYVDQTELEKFNKVEAGRYTVGLGQTQMGFCSVQEDVNSLCLT 108

Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
            V  L+E+ ++    +GRLEVG+ET+IDKSK++KT LM+LF+  GNTD+EG+D+TNACYG
Sbjct: 109 VVQQLMERTQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYG 168

Query: 464 GTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFES 643
           GTA L N  NW+ES+SWDGRY LV+C D AVY  G ARPTGGA A++ML+GP AP+V E 
Sbjct: 169 GTASLFNAANWMESSSWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLVGPEAPLVLER 228

Query: 644 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCY 769
            LRG+HM +VYDFYKP++ SEYP+VDGKLS  CYL ALD CY
Sbjct: 229 GLRGTHMENVYDFYKPDVTSEYPLVDGKLSIQCYLRALDKCY 270

>sp|P54961|HMCS1_BLAGE Hydroxymethylglutaryl-CoA synthase 1 OS=Blattella
        germanica GN=HMGCS-1 PE=2 SV=1

          Length = 453

 Score =  282 bits (720), Expect = 3e-075
 Identities = 132/226 (58%), Positives = 170/226 (75%), Gaps = 2/226 (0%)
 Frame = +2

Query: 116 DVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVTS 295
           DVGI+A+++ FP   V Q  LE +D  S GKY +GLGQ  + FCT+ ED+ S+    V+ 
Sbjct:   5 DVGIVALELIFPSQYVDQVDLEVYDNVSAGKYTVGLGQARMGFCTDREDINSLCLTVVSR 64

Query: 296 LLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTAV 475
           L+E++ I   QIGRLEVG+ET++DKSKS+KT LMQLF+   NTD+EGVD+ NACYGGT+ 
Sbjct:  65 LMERWSIPYSQIGRLEVGTETLLDKSKSVKTVLMQLFK--DNTDIEGVDTVNACYGGTSA 122

Query: 476 LLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLRG 655
           L N ++WVES+SWDGRY LV+  D AVYA+G ARPTGGA A++ML+G NAP+VF+  +R 
Sbjct: 123 LFNAISWVESSSWDGRYALVVAGDIAVYAKGSARPTGGAGAVAMLVGANAPLVFDRGVRS 182

Query: 656 SHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLR 793
           SHM H YDFYKP+L+S YP VDGKLS  CYL ALD CY+  C  ++
Sbjct: 183 SHMQHAYDFYKPDLSSLYPTVDGKLSIQCYLSALDHCYQLYCSKIQ 228

>sp|Q86HL5|HMCSB_DICDI Hydroxymethylglutaryl-CoA synthase B OS=Dictyostelium
        discoideum GN=hgsB PE=3 SV=1

          Length = 468

 Score =  278 bits (711), Expect = 3e-074
 Identities = 128/219 (58%), Positives = 167/219 (76%)
 Frame = +2

Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
           +D+GI A+DIYFP T V Q  L+ +D  S GKY IGLGQ  ++F  + ED++SM+  +V 
Sbjct:   5 KDIGICAIDIYFPQTYVNQSELKKYDKVSNGKYTIGLGQTNMSFVGDREDIVSMAMTSVK 64

Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
            ++ KY ID + IGRLEVG+ET+IDKSKS+K+ +M LF++ GNT +EGVD+ NACYGGT 
Sbjct:  65 MMMSKYSIDYQSIGRLEVGTETIIDKSKSVKSSIMSLFQEYGNTSLEGVDTLNACYGGTN 124

Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
            L N + W+ES+ WDGRY LV+  D AVY++G ARPTGGA  ++MLIGPNA ++F+  LR
Sbjct: 125 ALFNSLQWIESSYWDGRYALVVTGDIAVYSKGAARPTGGAGVVTMLIGPNATLIFDQSLR 184

Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCY 769
           G+HM +V DFYKP+L+SEYP VDGKLS  CYL ALD CY
Sbjct: 185 GTHMENVNDFYKPDLSSEYPYVDGKLSIECYLRALDKCY 223

>sp|O02734|HMCS2_PIG Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Sus
        scrofa GN=HMGCS2 PE=2 SV=1

          Length = 508

 Score =  278 bits (709), Expect = 5e-074
 Identities = 127/222 (57%), Positives = 162/222 (72%)
 Frame = +2

Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
           T  +DVGILA+++YFP   V Q  LE  D    G+Y +GLGQ  + FC+  ED+ S+   
Sbjct:  49 TWPKDVGILALEVYFPAQYVDQTDLEKFDNVEAGRYTVGLGQTHMGFCSVQEDINSLCLT 108

Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
            V  L+E+ ++    +G LEVG+ET+IDKSKS+KT LM+LF+  GNTD+EG+D+TNACYG
Sbjct: 109 VVQRLMERTQLPWDSVGWLEVGTETIIDKSKSVKTVLMELFQDSGNTDIEGIDTTNACYG 168

Query: 464 GTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFES 643
           GTA L N  NWVES++WDGRY +V+C D AVY  G +RPTGGA A++ML+GP AP+  E 
Sbjct: 169 GTASLFNAANWVESSAWDGRYAVVVCGDIAVYPRGNSRPTGGAGAVAMLVGPEAPLALER 228

Query: 644 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCY 769
            LRG+HM + YDFYKPN  SEYP+VDGKLS  CYL ALD CY
Sbjct: 229 GLRGTHMENAYDFYKPNATSEYPLVDGKLSIQCYLRALDRCY 270

>sp|P54839|HMCS_YEAST Hydroxymethylglutaryl-CoA synthase OS=Saccharomyces
        cerevisiae GN=ERG13 PE=1 SV=1

          Length = 491

 Score =  272 bits (694), Expect = 3e-072
 Identities = 131/236 (55%), Positives = 167/236 (70%), Gaps = 3/236 (1%)
 Frame = +2

Query:  77 KKKSFRYHSTMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTEL 256
           KK+      T  ++VGI  + IY P  CV Q  LE  DG S+GKY IGLGQ  ++F  + 
Sbjct:  35 KKQKTAEQKTRPQNVGIKGIQIYIPTQCVNQSELEKFDGVSQGKYTIGLGQTNMSFVNDR 94

Query: 257 EDVISMSFNAVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEG 436
           ED+ SMS   ++ L++ Y ID  +IGRLEVG+ET+IDKSKS+K+ LMQLF +  NTDVEG
Sbjct:  95 EDIYSMSLTVLSKLIKSYNIDTNKIGRLEVGTETLIDKSKSVKSVLMQLFGE--NTDVEG 152

Query: 437 VDSTNACYGGTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIG 616
           +D+ NACYGGT  L N +NW+ESN+WDGR  +V+C D A+Y +G ARPTGGA  ++M IG
Sbjct: 153 IDTLNACYGGTNALFNSLNWIESNAWDGRDAIVVCGDIAIYDKGAARPTGGAGTVAMWIG 212

Query: 617 PNAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCK 784
           P+APIVF+S +R S+M H YDFYKP+  SEYP VDG  S TCY+ ALD  YK   K
Sbjct: 213 PDAPIVFDS-VRASYMEHAYDFYKPDFTSEYPYVDGHFSLTCYVKALDQVYKSYSK 267

>sp|P54870|HMCS2_BLAGE Hydroxymethylglutaryl-CoA synthase 2 OS=Blattella
        germanica GN=HMGCS-2 PE=2 SV=1

          Length = 455

 Score =  272 bits (693), Expect = 4e-072
 Identities = 130/223 (58%), Positives = 160/223 (71%), Gaps = 1/223 (0%)
 Frame = +2

Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
           EDVGI+ +++ FP   V Q  LE +D  S GKY +GLGQD +  CT+ ED+ S+   AV 
Sbjct:   6 EDVGIIGIEMIFPSLYVDQAELETYDEVSPGKYTMGLGQDKMGVCTDREDINSLCLTAVD 65

Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
            L+E+  ID   IG LEVG+ET++DK KS+KT LMQLFE+ GNTDVEG+D+ NACY GTA
Sbjct:  66 KLMERNNIDYNDIGWLEVGTETILDKVKSVKTVLMQLFEESGNTDVEGIDTINACYRGTA 125

Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
            L N + W+ES+SWDGRY +V+  D A+YA+    PTGGA A+ MLIG NAPIV +  +R
Sbjct: 126 ALFNALIWIESSSWDGRYAIVVAADIAIYAK-ECSPTGGAGALLMLIGANAPIVIDRGVR 184

Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLC 781
            SHM H YDFYKP+L SEYPVVDGKLS  CYL ALD CY   C
Sbjct: 185 ASHMKHAYDFYKPDLMSEYPVVDGKLSVQCYLSALDHCYPRFC 227

>sp|P54874|HMCS_SCHPO Hydroxymethylglutaryl-CoA synthase OS=Schizosaccharomyces
        pombe GN=hcs1 PE=1 SV=1

          Length = 447

 Score =  261 bits (666), Expect = 5e-069
 Identities = 123/219 (56%), Positives = 161/219 (73%), Gaps = 2/219 (0%)
 Frame = +2

Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
           +D+GI  + +Y P   V+Q ALEAHDG S GKY IGLG   +AF  + ED+ S    A++
Sbjct:   6 KDIGIKGLVLYTPNQYVEQAALEAHDGVSTGKYTIGLGLTKMAFVDDREDIYSFGLTALS 65

Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
            L+++Y+ID  +IGRLEVG+ET+IDKSKS+K+ LMQLF    N +VEG+D  NACYGG  
Sbjct:  66 QLIKRYQIDISKIGRLEVGTETIIDKSKSVKSVLMQLFG--DNHNVEGIDCVNACYGGVN 123

Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
            L N ++W+ES++WDGR G+V+  D A+YA+G ARPTGGA  +++L+GPNAPIVFE  LR
Sbjct: 124 ALFNTIDWIESSAWDGRDGIVVAGDIALYAKGNARPTGGAGCVALLVGPNAPIVFEPGLR 183

Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCY 769
           G++M H YDFYKP+L SEYP VDG  S  CY+ ALD  Y
Sbjct: 184 GTYMQHAYDFYKPDLTSEYPYVDGHFSLECYVKALDGAY 222

>sp|P54871|HMCS_CAEEL Hydroxymethylglutaryl-CoA synthase OS=Caenorhabditis
        elegans GN=F25B4.6 PE=2 SV=2

          Length = 462

 Score =  208 bits (528), Expect = 5e-053
 Identities = 110/227 (48%), Positives = 145/227 (63%), Gaps = 5/227 (2%)
 Frame = +2

Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
           T   DVGI A+++YFP   V Q  LE  +  S GKY IGLGQ  + FC++ ED++S+S  
Sbjct:   9 TPVTDVGIGAIELYFPQNFVDQNDLEKFNNVSSGKYTIGLGQQQMGFCSDNEDIVSISLT 68

Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
               L+E YKI    IG L VG+ET+IDKSKS+KT LM LF   GN+D+EGVD  NAC+G
Sbjct:  69 VTRKLIETYKISTDSIGCLVVGTETMIDKSKSVKTALMDLFP--GNSDIEGVDIKNACFG 126

Query: 464 GTAVLLNCVNWVESN-SWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFE 640
           G   LL+ ++WV  N   D +  +V+  D A+Y EGPAR TGGA AI+ LI P+A I  +
Sbjct: 127 GAQALLHAIDWVTVNHPLDKKNAIVVVADIAIYEEGPARCTGGAGAIAFLICPDASIPID 186

Query: 641 SKLRGSHMAHVYDFYKP--NLASEYPVVDGKLSQTCYLMALDSCYKH 775
            +    HM + +DF+KP   + SEYPVVDG LS + YL A+   Y +
Sbjct: 187 RQFSACHMKNTWDFFKPITPIPSEYPVVDGSLSLSSYLEAVRMTYTY 233

  Database: UniProt/SwissProt
    Posted date:  Sat Aug 07 14:36:18 2010
  Number of letters in database: 182,829,261
  Number of sequences in database:  518,415

Lambda     K     H
   0.267   0.041    0.140
Gapped
Lambda     K     H
   0.267   0.041    0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 3,154,264,487
Number of Sequences: 518415
Number of Extensions: 3154264487
Number of Successful Extensions: 47263005
Number of sequences better than 0.0: 0