BLASTX 7.6.2
Query= UN00725 /QuerySize=822
(821 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P54873|HMCS_ARATH Hydroxymethylglutaryl-CoA synthase OS=Arabi... 449 1e-125
sp|Q5R7Z9|HMCS1_PONAB Hydroxymethylglutaryl-CoA synthase, cytopl... 305 4e-082
sp|Q01581|HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthase, cytopl... 302 2e-081
sp|P23228|HMCS1_CHICK Hydroxymethylglutaryl-CoA synthase, cytopl... 299 2e-080
sp|Q8JZK9|HMCS1_MOUSE Hydroxymethylglutaryl-CoA synthase, cytopl... 299 3e-080
sp|P54872|HMCSA_DICDI Hydroxymethylglutaryl-CoA synthase A OS=Di... 299 3e-080
sp|P17425|HMCS1_RAT Hydroxymethylglutaryl-CoA synthase, cytoplas... 297 6e-080
sp|P13704|HMCS1_CRIGR Hydroxymethylglutaryl-CoA synthase, cytopl... 297 1e-079
sp|P54868|HMCS2_HUMAN Hydroxymethylglutaryl-CoA synthase, mitoch... 291 4e-078
sp|P54869|HMCS2_MOUSE Hydroxymethylglutaryl-CoA synthase, mitoch... 289 3e-077
sp|P22791|HMCS2_RAT Hydroxymethylglutaryl-CoA synthase, mitochon... 285 2e-076
sp|Q2KIE6|HMCS2_BOVIN Hydroxymethylglutaryl-CoA synthase, mitoch... 284 7e-076
sp|P54961|HMCS1_BLAGE Hydroxymethylglutaryl-CoA synthase 1 OS=Bl... 282 3e-075
sp|Q86HL5|HMCSB_DICDI Hydroxymethylglutaryl-CoA synthase B OS=Di... 278 3e-074
sp|O02734|HMCS2_PIG Hydroxymethylglutaryl-CoA synthase, mitochon... 278 5e-074
sp|P54839|HMCS_YEAST Hydroxymethylglutaryl-CoA synthase OS=Sacch... 272 3e-072
sp|P54870|HMCS2_BLAGE Hydroxymethylglutaryl-CoA synthase 2 OS=Bl... 272 4e-072
sp|P54874|HMCS_SCHPO Hydroxymethylglutaryl-CoA synthase OS=Schiz... 261 5e-069
sp|P54871|HMCS_CAEEL Hydroxymethylglutaryl-CoA synthase OS=Caeno... 208 5e-053
>sp|P54873|HMCS_ARATH Hydroxymethylglutaryl-CoA synthase OS=Arabidopsis thaliana
GN=HMGS PE=2 SV=2
Length = 461
Score = 449 bits (1154), Expect = 1e-125
Identities = 217/234 (92%), Positives = 222/234 (94%)
Frame = +2
Query: 107 MAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNA 286
MA++VGILAMDIYFPPTCVQQEALEAHDGASKGKY IGLGQDCLAFCTELEDVISMSFNA
Sbjct: 1 MAKNVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNA 60
Query: 287 VTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGG 466
VTSL EKYKIDP QIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGG
Sbjct: 61 VTSLFEKYKIDPNQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGG 120
Query: 467 TAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESK 646
TA LLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAI+MLIGP+APIVFESK
Sbjct: 121 TAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPDAPIVFESK 180
Query: 647 LRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLRNSKAK 808
LR SHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLC + K
Sbjct: 181 LRASHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKIEGK 234
>sp|Q5R7Z9|HMCS1_PONAB Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Pongo
abelii GN=HMGCS1 PE=2 SV=1
Length = 520
Score = 305 bits (779), Expect = 4e-082
Identities = 140/227 (61%), Positives = 175/227 (77%)
Frame = +2
Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
+DVGI+A++IYFP V Q LE +DG + GKY IGLGQ + FCT+ ED+ S+ V
Sbjct: 15 KDVGIVALEIYFPSQYVDQAELEKYDGVAAGKYTIGLGQAKMGFCTDREDINSLCMTVVQ 74
Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
+L+E+ + IGRLEVG+ET+IDKSKS+KT LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct: 75 NLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTA 134
Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
+ N VNW+ES+SWDGRY LV+ D AVYA G ARPTGG A+++LIGPNAP++FE LR
Sbjct: 135 AVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLR 194
Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLR 793
G+HM H YDFYKP++ SEYP+VDGKLS CYL ALD CY CK +R
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIR 241
>sp|Q01581|HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Homo
sapiens GN=HMGCS1 PE=1 SV=2
Length = 520
Score = 302 bits (773), Expect = 2e-081
Identities = 139/226 (61%), Positives = 173/226 (76%)
Frame = +2
Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
+DVGI+A++IYFP V Q LE +DG GKY IGLGQ + FCT+ ED+ S+ V
Sbjct: 15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQ 74
Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
+L+E+ + IGRLEVG+ET+IDKSKS+KT LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct: 75 NLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTA 134
Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
+ N VNW+ES+SWDGRY LV+ D AVYA G ARPTGG A+++LIGPNAP++FE LR
Sbjct: 135 AVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLR 194
Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSL 790
G+HM H YDFYKP++ SEYP+VDGKLS CYL ALD CY CK +
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI 240
>sp|P23228|HMCS1_CHICK Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Gallus
gallus GN=HMGCS1 PE=1 SV=1
Length = 522
Score = 299 bits (764), Expect = 2e-080
Identities = 139/223 (62%), Positives = 170/223 (76%)
Frame = +2
Query: 101 STMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSF 280
S +DVGI+A++IYFP V Q LE +DG GKY IGLGQ + FC++ ED+ S+
Sbjct: 11 SCWPKDVGIVALEIYFPSQYVDQTELEKYDGVDAGKYTIGLGQSKMGFCSDREDINSLCL 70
Query: 281 NAVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACY 460
V L+E+ + IGRLEVG+ET+IDKSKS+KT LMQLFE+ GNTDVEG+D+TNACY
Sbjct: 71 TVVQKLMERNSLSYDCIGRLEVGTETIIDKSKSVKTVLMQLFEESGNTDVEGIDTTNACY 130
Query: 461 GGTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFE 640
GGTA L N +NW+ES+SWDGRY LV+ D AVYA G ARPTGGA A++ML+G NAP++FE
Sbjct: 131 GGTAALFNAINWIESSSWDGRYALVVAGDIAVYATGNARPTGGAGAVAMLVGSNAPLIFE 190
Query: 641 SKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCY 769
LRG+HM H YDFYKP++ SEYPVVDGKLS CYL ALD CY
Sbjct: 191 RGLRGTHMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALDRCY 233
>sp|Q8JZK9|HMCS1_MOUSE Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Mus
musculus GN=Hmgcs1 PE=1 SV=1
Length = 520
Score = 299 bits (763), Expect = 3e-080
Identities = 138/227 (60%), Positives = 173/227 (76%)
Frame = +2
Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
+DVGI+A++IYFP V Q LE +DG GKY IGLGQ + FCT+ ED+ S+ V
Sbjct: 15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQ 74
Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
L+E++ + IGRLEVG+ET+IDKSKS+K+ LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct: 75 KLMERHSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTA 134
Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
+ N VNWVES+SWDGRY LV+ D A+YA G ARPTGG A+++LIGPNAP++F+ LR
Sbjct: 135 AVFNAVNWVESSSWDGRYALVVAGDIAIYATGNARPTGGVGAVALLIGPNAPLIFDRGLR 194
Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLR 793
G+HM H YDFYKP++ SEYPVVDGKLS CYL ALD CY K +R
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIR 241
>sp|P54872|HMCSA_DICDI Hydroxymethylglutaryl-CoA synthase A OS=Dictyostelium
discoideum GN=hgsA PE=1 SV=2
Length = 482
Score = 299 bits (763), Expect = 3e-080
Identities = 138/236 (58%), Positives = 176/236 (74%)
Frame = +2
Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
T E++GI +++YFP T V QE LE DG S+GKY +GLGQ +AFC + ED+ S+S N
Sbjct: 2 TKPENIGIHGIEVYFPSTYVAQEDLEKFDGVSQGKYTLGLGQTNMAFCGDREDIYSLSLN 61
Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
AV +L++K+ +DP IGRLEVG+ETVIDKSKS+KT LM LF K GNT ++G+D+ NACYG
Sbjct: 62 AVNNLMDKFNVDPNSIGRLEVGTETVIDKSKSVKTVLMDLFAKHGNTSIDGIDTINACYG 121
Query: 464 GTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFES 643
GT+ L N + W+ES+ WDGR +V+ D AVY +GPARPTGGA ++MLIGPNAPI FES
Sbjct: 122 GTSALHNALQWMESSYWDGRNAIVVAGDIAVYEKGPARPTGGAGVVAMLIGPNAPITFES 181
Query: 644 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLRNSKAKS 811
LRG HM +VYDFYKP++ SEYP VDGKLS +CY A+D+CY K+ KS
Sbjct: 182 GLRGVHMENVYDFYKPDMDSEYPRVDGKLSISCYFRAIDNCYNRYAKAFEKKYGKS 237
>sp|P17425|HMCS1_RAT Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Rattus
norvegicus GN=Hmgcs1 PE=1 SV=1
Length = 520
Score = 297 bits (760), Expect = 6e-080
Identities = 137/227 (60%), Positives = 172/227 (75%)
Frame = +2
Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
+DVGI+A++IYFP V Q LE +DG GKY IGLGQ + FCT+ ED+ S+ V
Sbjct: 15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQ 74
Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
L+E+ + IGRLEVG+ET+IDKSKS+K+ LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct: 75 KLMERNSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTA 134
Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
+ N VNW+ES+SWDGRY LV+ D A+YA G ARPTGG A+++LIGPNAP++F+ LR
Sbjct: 135 AVFNAVNWIESSSWDGRYALVVAGDIAIYASGNARPTGGVGAVALLIGPNAPVIFDRGLR 194
Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLR 793
G+HM H YDFYKP++ SEYPVVDGKLS CYL ALD CY K +R
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIR 241
>sp|P13704|HMCS1_CRIGR Hydroxymethylglutaryl-CoA synthase, cytoplasmic
OS=Cricetulus griseus GN=HMGCS1 PE=3 SV=1
Length = 520
Score = 297 bits (758), Expect = 1e-079
Identities = 136/227 (59%), Positives = 173/227 (76%)
Frame = +2
Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
+DVGI+A++IYFP V Q LE +DG GKY IGLGQ + FCT+ ED+ S+ V
Sbjct: 15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQ 74
Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
+L+E+ + IGRLEVG+ET+IDKSKS+K+ LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct: 75 NLMERNSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTA 134
Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
+ N VNW+ES+SWDGRY LV+ D A+YA G ARPTGG A+++LIGPNAP++F+ LR
Sbjct: 135 AVFNAVNWIESSSWDGRYALVVAGDIAIYATGNARPTGGVGAVALLIGPNAPLIFDRGLR 194
Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLR 793
G+HM H YDFYKP++ SEYP+VDGKLS CYL ALD CY K +R
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYRKKIR 241
>sp|P54868|HMCS2_HUMAN Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Homo
sapiens GN=HMGCS2 PE=1 SV=1
Length = 508
Score = 291 bits (744), Expect = 4e-078
Identities = 134/231 (58%), Positives = 171/231 (74%)
Frame = +2
Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
T +DVGILA+++YFP V Q LE ++ GKY +GLGQ + FC+ ED+ S+
Sbjct: 49 TWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLT 108
Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
V L+E+ ++ +GRLEVG+ET+IDKSK++KT LM+LF+ GNTD+EG+D+TNACYG
Sbjct: 109 VVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYG 168
Query: 464 GTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFES 643
GTA L N NW+ES+SWDGRY +V+C D AVY G ARPTGGA A++MLIGP AP+ E
Sbjct: 169 GTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALER 228
Query: 644 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLRN 796
LRG+HM +VYDFYKPNLASEYP+VDGKLS CYL ALD CY K ++N
Sbjct: 229 GLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQN 279
>sp|P54869|HMCS2_MOUSE Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Mus
musculus GN=Hmgcs2 PE=1 SV=2
Length = 508
Score = 289 bits (737), Expect = 3e-077
Identities = 135/231 (58%), Positives = 169/231 (73%)
Frame = +2
Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
T +DVGILA+++YFP V Q LE + GKY +GLGQ + FC+ ED+ S+
Sbjct: 49 TWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLT 108
Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
V L+E+ K+ +GRLEVG+ET+IDKSK++KT LM+LF+ GNTD+EG+D+TNACYG
Sbjct: 109 VVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYG 168
Query: 464 GTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFES 643
GTA L N NW+ES+ WDGRY LV+C D AVY G ARPTGGA A++MLIGP AP+V E
Sbjct: 169 GTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQ 228
Query: 644 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLRN 796
LRG+HM + YDFYKPNLASEYP+VDGKLS CYL ALD CY K ++N
Sbjct: 229 GLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRKKIQN 279
>sp|P22791|HMCS2_RAT Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Rattus
norvegicus GN=Hmgcs2 PE=2 SV=1
Length = 508
Score = 285 bits (729), Expect = 2e-076
Identities = 133/231 (57%), Positives = 168/231 (72%)
Frame = +2
Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
T +DVGILA+++YFP V Q LE + GKY +GLGQ + FC+ ED+ S+
Sbjct: 49 TWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLT 108
Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
V L+E+ K+ +GRLEVG+ET+IDKSK++KT LM+LF+ GNTD+EG+D+TNACYG
Sbjct: 109 VVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYG 168
Query: 464 GTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFES 643
GTA L N NW+ES+ WDGRY LV+C D AVY G RPTGGA A++MLIGP AP+V E
Sbjct: 169 GTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNPRPTGGAGAVAMLIGPKAPLVLEQ 228
Query: 644 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLRN 796
LRG+HM + YDFYKPNLASEYP+VDGKLS CYL ALD CY + ++N
Sbjct: 229 GLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRRKIQN 279
>sp|Q2KIE6|HMCS2_BOVIN Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Bos
taurus GN=HMGCS2 PE=2 SV=1
Length = 508
Score = 284 bits (725), Expect = 7e-076
Identities = 131/222 (59%), Positives = 166/222 (74%)
Frame = +2
Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
T +DVGILAM++YFP V Q LE + G+Y +GLGQ + FC+ EDV S+
Sbjct: 49 TWPKDVGILAMEVYFPAQYVDQTELEKFNKVEAGRYTVGLGQTQMGFCSVQEDVNSLCLT 108
Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
V L+E+ ++ +GRLEVG+ET+IDKSK++KT LM+LF+ GNTD+EG+D+TNACYG
Sbjct: 109 VVQQLMERTQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYG 168
Query: 464 GTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFES 643
GTA L N NW+ES+SWDGRY LV+C D AVY G ARPTGGA A++ML+GP AP+V E
Sbjct: 169 GTASLFNAANWMESSSWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLVGPEAPLVLER 228
Query: 644 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCY 769
LRG+HM +VYDFYKP++ SEYP+VDGKLS CYL ALD CY
Sbjct: 229 GLRGTHMENVYDFYKPDVTSEYPLVDGKLSIQCYLRALDKCY 270
>sp|P54961|HMCS1_BLAGE Hydroxymethylglutaryl-CoA synthase 1 OS=Blattella
germanica GN=HMGCS-1 PE=2 SV=1
Length = 453
Score = 282 bits (720), Expect = 3e-075
Identities = 132/226 (58%), Positives = 170/226 (75%), Gaps = 2/226 (0%)
Frame = +2
Query: 116 DVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVTS 295
DVGI+A+++ FP V Q LE +D S GKY +GLGQ + FCT+ ED+ S+ V+
Sbjct: 5 DVGIVALELIFPSQYVDQVDLEVYDNVSAGKYTVGLGQARMGFCTDREDINSLCLTVVSR 64
Query: 296 LLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTAV 475
L+E++ I QIGRLEVG+ET++DKSKS+KT LMQLF+ NTD+EGVD+ NACYGGT+
Sbjct: 65 LMERWSIPYSQIGRLEVGTETLLDKSKSVKTVLMQLFK--DNTDIEGVDTVNACYGGTSA 122
Query: 476 LLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLRG 655
L N ++WVES+SWDGRY LV+ D AVYA+G ARPTGGA A++ML+G NAP+VF+ +R
Sbjct: 123 LFNAISWVESSSWDGRYALVVAGDIAVYAKGSARPTGGAGAVAMLVGANAPLVFDRGVRS 182
Query: 656 SHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCKSLR 793
SHM H YDFYKP+L+S YP VDGKLS CYL ALD CY+ C ++
Sbjct: 183 SHMQHAYDFYKPDLSSLYPTVDGKLSIQCYLSALDHCYQLYCSKIQ 228
>sp|Q86HL5|HMCSB_DICDI Hydroxymethylglutaryl-CoA synthase B OS=Dictyostelium
discoideum GN=hgsB PE=3 SV=1
Length = 468
Score = 278 bits (711), Expect = 3e-074
Identities = 128/219 (58%), Positives = 167/219 (76%)
Frame = +2
Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
+D+GI A+DIYFP T V Q L+ +D S GKY IGLGQ ++F + ED++SM+ +V
Sbjct: 5 KDIGICAIDIYFPQTYVNQSELKKYDKVSNGKYTIGLGQTNMSFVGDREDIVSMAMTSVK 64
Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
++ KY ID + IGRLEVG+ET+IDKSKS+K+ +M LF++ GNT +EGVD+ NACYGGT
Sbjct: 65 MMMSKYSIDYQSIGRLEVGTETIIDKSKSVKSSIMSLFQEYGNTSLEGVDTLNACYGGTN 124
Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
L N + W+ES+ WDGRY LV+ D AVY++G ARPTGGA ++MLIGPNA ++F+ LR
Sbjct: 125 ALFNSLQWIESSYWDGRYALVVTGDIAVYSKGAARPTGGAGVVTMLIGPNATLIFDQSLR 184
Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCY 769
G+HM +V DFYKP+L+SEYP VDGKLS CYL ALD CY
Sbjct: 185 GTHMENVNDFYKPDLSSEYPYVDGKLSIECYLRALDKCY 223
>sp|O02734|HMCS2_PIG Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Sus
scrofa GN=HMGCS2 PE=2 SV=1
Length = 508
Score = 278 bits (709), Expect = 5e-074
Identities = 127/222 (57%), Positives = 162/222 (72%)
Frame = +2
Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
T +DVGILA+++YFP V Q LE D G+Y +GLGQ + FC+ ED+ S+
Sbjct: 49 TWPKDVGILALEVYFPAQYVDQTDLEKFDNVEAGRYTVGLGQTHMGFCSVQEDINSLCLT 108
Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
V L+E+ ++ +G LEVG+ET+IDKSKS+KT LM+LF+ GNTD+EG+D+TNACYG
Sbjct: 109 VVQRLMERTQLPWDSVGWLEVGTETIIDKSKSVKTVLMELFQDSGNTDIEGIDTTNACYG 168
Query: 464 GTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFES 643
GTA L N NWVES++WDGRY +V+C D AVY G +RPTGGA A++ML+GP AP+ E
Sbjct: 169 GTASLFNAANWVESSAWDGRYAVVVCGDIAVYPRGNSRPTGGAGAVAMLVGPEAPLALER 228
Query: 644 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCY 769
LRG+HM + YDFYKPN SEYP+VDGKLS CYL ALD CY
Sbjct: 229 GLRGTHMENAYDFYKPNATSEYPLVDGKLSIQCYLRALDRCY 270
>sp|P54839|HMCS_YEAST Hydroxymethylglutaryl-CoA synthase OS=Saccharomyces
cerevisiae GN=ERG13 PE=1 SV=1
Length = 491
Score = 272 bits (694), Expect = 3e-072
Identities = 131/236 (55%), Positives = 167/236 (70%), Gaps = 3/236 (1%)
Frame = +2
Query: 77 KKKSFRYHSTMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTEL 256
KK+ T ++VGI + IY P CV Q LE DG S+GKY IGLGQ ++F +
Sbjct: 35 KKQKTAEQKTRPQNVGIKGIQIYIPTQCVNQSELEKFDGVSQGKYTIGLGQTNMSFVNDR 94
Query: 257 EDVISMSFNAVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEG 436
ED+ SMS ++ L++ Y ID +IGRLEVG+ET+IDKSKS+K+ LMQLF + NTDVEG
Sbjct: 95 EDIYSMSLTVLSKLIKSYNIDTNKIGRLEVGTETLIDKSKSVKSVLMQLFGE--NTDVEG 152
Query: 437 VDSTNACYGGTAVLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIG 616
+D+ NACYGGT L N +NW+ESN+WDGR +V+C D A+Y +G ARPTGGA ++M IG
Sbjct: 153 IDTLNACYGGTNALFNSLNWIESNAWDGRDAIVVCGDIAIYDKGAARPTGGAGTVAMWIG 212
Query: 617 PNAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCK 784
P+APIVF+S +R S+M H YDFYKP+ SEYP VDG S TCY+ ALD YK K
Sbjct: 213 PDAPIVFDS-VRASYMEHAYDFYKPDFTSEYPYVDGHFSLTCYVKALDQVYKSYSK 267
>sp|P54870|HMCS2_BLAGE Hydroxymethylglutaryl-CoA synthase 2 OS=Blattella
germanica GN=HMGCS-2 PE=2 SV=1
Length = 455
Score = 272 bits (693), Expect = 4e-072
Identities = 130/223 (58%), Positives = 160/223 (71%), Gaps = 1/223 (0%)
Frame = +2
Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
EDVGI+ +++ FP V Q LE +D S GKY +GLGQD + CT+ ED+ S+ AV
Sbjct: 6 EDVGIIGIEMIFPSLYVDQAELETYDEVSPGKYTMGLGQDKMGVCTDREDINSLCLTAVD 65
Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
L+E+ ID IG LEVG+ET++DK KS+KT LMQLFE+ GNTDVEG+D+ NACY GTA
Sbjct: 66 KLMERNNIDYNDIGWLEVGTETILDKVKSVKTVLMQLFEESGNTDVEGIDTINACYRGTA 125
Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
L N + W+ES+SWDGRY +V+ D A+YA+ PTGGA A+ MLIG NAPIV + +R
Sbjct: 126 ALFNALIWIESSSWDGRYAIVVAADIAIYAK-ECSPTGGAGALLMLIGANAPIVIDRGVR 184
Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLC 781
SHM H YDFYKP+L SEYPVVDGKLS CYL ALD CY C
Sbjct: 185 ASHMKHAYDFYKPDLMSEYPVVDGKLSVQCYLSALDHCYPRFC 227
>sp|P54874|HMCS_SCHPO Hydroxymethylglutaryl-CoA synthase OS=Schizosaccharomyces
pombe GN=hcs1 PE=1 SV=1
Length = 447
Score = 261 bits (666), Expect = 5e-069
Identities = 123/219 (56%), Positives = 161/219 (73%), Gaps = 2/219 (0%)
Frame = +2
Query: 113 EDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFNAVT 292
+D+GI + +Y P V+Q ALEAHDG S GKY IGLG +AF + ED+ S A++
Sbjct: 6 KDIGIKGLVLYTPNQYVEQAALEAHDGVSTGKYTIGLGLTKMAFVDDREDIYSFGLTALS 65
Query: 293 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 472
L+++Y+ID +IGRLEVG+ET+IDKSKS+K+ LMQLF N +VEG+D NACYGG
Sbjct: 66 QLIKRYQIDISKIGRLEVGTETIIDKSKSVKSVLMQLFG--DNHNVEGIDCVNACYGGVN 123
Query: 473 VLLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFESKLR 652
L N ++W+ES++WDGR G+V+ D A+YA+G ARPTGGA +++L+GPNAPIVFE LR
Sbjct: 124 ALFNTIDWIESSAWDGRDGIVVAGDIALYAKGNARPTGGAGCVALLVGPNAPIVFEPGLR 183
Query: 653 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCY 769
G++M H YDFYKP+L SEYP VDG S CY+ ALD Y
Sbjct: 184 GTYMQHAYDFYKPDLTSEYPYVDGHFSLECYVKALDGAY 222
>sp|P54871|HMCS_CAEEL Hydroxymethylglutaryl-CoA synthase OS=Caenorhabditis
elegans GN=F25B4.6 PE=2 SV=2
Length = 462
Score = 208 bits (528), Expect = 5e-053
Identities = 110/227 (48%), Positives = 145/227 (63%), Gaps = 5/227 (2%)
Frame = +2
Query: 104 TMAEDVGILAMDIYFPPTCVQQEALEAHDGASKGKYIIGLGQDCLAFCTELEDVISMSFN 283
T DVGI A+++YFP V Q LE + S GKY IGLGQ + FC++ ED++S+S
Sbjct: 9 TPVTDVGIGAIELYFPQNFVDQNDLEKFNNVSSGKYTIGLGQQQMGFCSDNEDIVSISLT 68
Query: 284 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 463
L+E YKI IG L VG+ET+IDKSKS+KT LM LF GN+D+EGVD NAC+G
Sbjct: 69 VTRKLIETYKISTDSIGCLVVGTETMIDKSKSVKTALMDLFP--GNSDIEGVDIKNACFG 126
Query: 464 GTAVLLNCVNWVESN-SWDGRYGLVICTDSAVYAEGPARPTGGAAAISMLIGPNAPIVFE 640
G LL+ ++WV N D + +V+ D A+Y EGPAR TGGA AI+ LI P+A I +
Sbjct: 127 GAQALLHAIDWVTVNHPLDKKNAIVVVADIAIYEEGPARCTGGAGAIAFLICPDASIPID 186
Query: 641 SKLRGSHMAHVYDFYKP--NLASEYPVVDGKLSQTCYLMALDSCYKH 775
+ HM + +DF+KP + SEYPVVDG LS + YL A+ Y +
Sbjct: 187 RQFSACHMKNTWDFFKPITPIPSEYPVVDGSLSLSSYLEAVRMTYTY 233
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 3,154,264,487
Number of Sequences: 518415
Number of Extensions: 3154264487
Number of Successful Extensions: 47263005
Number of sequences better than 0.0: 0
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