BLASTX 7.6.2
Query= UN01011 /QuerySize=1490
(1489 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabi... 174 1e-042
sp|Q66L42|M3K10_MOUSE Mitogen-activated protein kinase kinase ki... 164 2e-039
sp|Q7T2V3|M3K10_XENLA Mitogen-activated protein kinase kinase ki... 159 4e-038
sp|Q02779|M3K10_HUMAN Mitogen-activated protein kinase kinase ki... 159 8e-038
sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase ki... 155 8e-037
sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase ki... 155 8e-037
sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kina... 155 8e-037
sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kin... 136 4e-031
sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kin... 136 7e-031
sp|P18160|PYK1_DICDI Dual specificity protein kinase pyk1 OS=Dic... 136 7e-031
sp|Q05609|CTR1_ARATH Serine/threonine-protein kinase CTR1 OS=Ara... 134 3e-030
sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase ki... 123 4e-027
sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase ki... 123 4e-027
sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kina... 123 5e-027
sp|Q23915|KINX_DICDI Probable serine/threonine-protein kinase ki... 121 2e-026
sp|A8X775|DLK1_CAEBR Mitogen-activated protein kinase kinase kin... 113 5e-024
sp|O01700|DLK1_CAEEL Mitogen-activated protein kinase kinase kin... 112 8e-024
sp|Q03963|E2AK2_MOUSE Interferon-induced, double-stranded RNA-ac... 94 2e-018
sp|Q869N2|PAKB_DICDI Serine/threonine-protein kinase pakB OS=Dic... 94 2e-018
sp|Q55GV3|PAKC_DICDI Serine/threonine-protein kinase pakC OS=Dic... 88 1e-016
>sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabidopsis thaliana
GN=HT1 PE=1 SV=1
Length = 390
Score = 174 bits (441), Expect = 1e-042
Identities = 83/201 (41%), Positives = 127/201 (63%), Gaps = 7/201 (3%)
Frame = +1
Query: 604 LGHGNSAHPAKAC------CVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLS 765
L H N AC C++ EY++ G L+ +L KK L I+ V++LALD++RG+
Sbjct: 142 LFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGME 201
Query: 766 YLHSKAIVHRDVKSENMLLEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEG 945
YLHS+ ++HRD+KS N+LL +K+ADFG + +E Q ++ G GT +MAPE+++
Sbjct: 202 YLHSQGVIHRDLKSNNLLLNDEMRVKVADFGTSCLETQ-CREAKGNMGTYRWMAPEMIKE 260
Query: 946 KPYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMR 1125
KPY RK DVYSFG+ LWE+ +P+ + + + AV KN RP +P C ++A++++
Sbjct: 261 KPYTRKVDVYSFGIVLWELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALAHLIK 320
Query: 1126 RCWDPNPDKRPEMEEVVKLLE 1188
RCW NP KRP+ +V +LE
Sbjct: 321 RCWSENPSKRPDFSNIVAVLE 341
>sp|Q66L42|M3K10_MOUSE Mitogen-activated protein kinase kinase kinase 10 OS=Mus
musculus GN=Map3k10 PE=2 SV=2
Length = 940
Score = 164 bits (414), Expect = 2e-039
Identities = 104/319 (32%), Positives = 163/319 (51%), Gaps = 46/319 (14%)
Frame = +1
Query: 286 PSSSAAVKSRKSPMQEWEIDLSKLDMNHVLARGTYGTVYRGVYAGQQVAVKV--LDWGED 459
P++ AA + P EI +L + ++ G +G VYR V+ G++VAVK LD D
Sbjct: 78 PAAPAAPSDLQLPQ---EIPFHELQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERD 134
Query: 460 GVSTADDLRISFEQEVAVWQKLHHPNVTKFIGASMGTSDLKIPSSSDSLGHGNSAHPAKA 639
TA+ +R QE ++ L HPN+ GA + +L
Sbjct: 135 PAVTAEQVR----QEARLFGALQHPNIIALRGACLSPPNL-------------------- 170
Query: 640 CCVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKA---IVHRDVKSE 810
C+V+EY GG L + L + ++P ++ A+ +ARG++YLH+ A I+HRD+KS
Sbjct: 171 -CLVMEYARGGALSRVLAGR---RVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSI 226
Query: 811 NMLL--------EPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKC 966
N+L+ + LKI DFG+AR E M+ GT +MAPEV+ +++
Sbjct: 227 NILILEAIENHNLADTVLKITDFGLAR-EWHKTTKMSA-AGTYAWMAPEVIRLSLFSKSS 284
Query: 967 DVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNP 1146
DV+SFGV LWE+ ++PY + +++ V L IP CP+ A ++ CWDP+P
Sbjct: 285 DVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDP 344
Query: 1147 DKRPEMEEVVKLLEAVNTS 1203
RP+ ++K LE + S
Sbjct: 345 HGRPDFGSILKQLEVIEQS 363
>sp|Q7T2V3|M3K10_XENLA Mitogen-activated protein kinase kinase kinase 10
OS=Xenopus laevis GN=map3k10 PE=1 SV=1
Length = 1005
Score = 159 bits (402), Expect = 4e-038
Identities = 99/302 (32%), Positives = 158/302 (52%), Gaps = 43/302 (14%)
Frame = +1
Query: 337 EIDLSKLDMNHVLARGTYGTVYRGVYAGQQVAVKVL--DWGEDGVSTADDLRISFEQEVA 510
EI+ +L+++ ++ G +G VY+G++ ++VAVK + D ED TA+++R QE
Sbjct: 112 EIEFDELNLDEIIGVGGFGKVYKGLWRDEEVAVKAVRHDPDEDINVTAENVR----QEAK 167
Query: 511 VWQKLHHPNVTKFIGASMGTSDLKIPSSSDSLGHGNSAHPAKACCVVVEYVAGGTLKKFL 690
++ L HPN+ G + L C+V+EY GG L + L
Sbjct: 168 IFCMLCHPNIIALTGVCLKPPHL---------------------CLVMEYARGGPLHRAL 206
Query: 691 IKKYRTKLPIKDVIQLALDLARGLSYLHSKAIV---HRDVKSENMLLEP--------NKT 837
K K+P ++ A+ +A+G++YLH++AIV HRD+ S N+L+ NKT
Sbjct: 207 AGK---KVPAHVLVNWAVQIAKGMTYLHNEAIVPIIHRDLGSSNILILEKAENDDLFNKT 263
Query: 838 LKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLWEIYCCDM 1017
L I DFG+AR E Q M+ GT +MAPEV+ +++ DV+SFGV LWE+ ++
Sbjct: 264 LNITDFGLAR-EWQKTTKMSA-AGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEV 321
Query: 1018 PYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLEAVN 1197
PY + +++ V L IP CP+ I+ CWDP+P RP +++ L +
Sbjct: 322 PYREIDALAVAYGVAMNKLTLPIPSTCPEPFVRILEACWDPDPHSRPTFSCILEQLTTIE 381
Query: 1198 TS 1203
S
Sbjct: 382 QS 383
>sp|Q02779|M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 OS=Homo
sapiens GN=MAP3K10 PE=1 SV=3
Length = 954
Score = 159 bits (400), Expect = 8e-038
Identities = 102/319 (31%), Positives = 161/319 (50%), Gaps = 46/319 (14%)
Frame = +1
Query: 286 PSSSAAVKSRKSPMQEWEIDLSKLDMNHVLARGTYGTVYRGVYAGQQVAVKV--LDWGED 459
P + AA + P EI +L + ++ G +G VYR ++ G++VAVK LD +D
Sbjct: 78 PGAPAAPAGLQLPQ---EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKD 134
Query: 460 GVSTADDLRISFEQEVAVWQKLHHPNVTKFIGASMGTSDLKIPSSSDSLGHGNSAHPAKA 639
TA+ + QE ++ L HPN+ GA + L
Sbjct: 135 PAVTAEQVC----QEARLFGALQHPNIIALRGACLNPPHL-------------------- 170
Query: 640 CCVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKA---IVHRDVKSE 810
C+V+EY GG L + L + ++P ++ A+ +ARG++YLH+ A I+HRD+KS
Sbjct: 171 -CLVMEYARGGALSRVLAGR---RVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSI 226
Query: 811 NMLL--------EPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKC 966
N+L+ + LKI DFG+AR E M+ GT +MAPEV+ +++
Sbjct: 227 NILILEAIENHNLADTVLKITDFGLAR-EWHKTTKMSA-AGTYAWMAPEVIRLSLFSKSS 284
Query: 967 DVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNP 1146
DV+SFGV LWE+ ++PY + +++ V L IP CP+ A ++ CWDP+P
Sbjct: 285 DVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDP 344
Query: 1147 DKRPEMEEVVKLLEAVNTS 1203
RP+ ++K LE + S
Sbjct: 345 HGRPDFGSILKRLEVIEQS 363
>sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 OS=Homo
sapiens GN=MAP3K11 PE=1 SV=1
Length = 847
Score = 155 bits (391), Expect = 8e-037
Identities = 105/328 (32%), Positives = 164/328 (50%), Gaps = 49/328 (14%)
Frame = +1
Query: 262 WDLNMGGQ----PSSSAAVKSRKSPMQEWEIDLSKLDMNHVLARGTYGTVYRGVYAGQQV 429
W +GGQ PS+ + P + +L + V+ G +G VYRG + G+ V
Sbjct: 84 WAGQVGGQVGIFPSNYVSRGGGPPPCE--VASFQELRLEEVIGIGGFGKVYRGSWRGELV 141
Query: 430 AVKVL--DWGEDGVSTADDLRISFEQEVAVWQKLHHPNVTKFIGASMGTSDLKIPSSSDS 603
AVK D ED TA+ +R QE ++ L HPN+ + +L
Sbjct: 142 AVKAARQDPDEDISVTAESVR----QEARLFAMLAHPNIIALKAVCLEEPNL-------- 189
Query: 604 LGHGNSAHPAKACCVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKA 783
C+V+EY AGG L + L + ++P ++ A+ +ARG+ YLH +A
Sbjct: 190 -------------CLVMEYAAGGPLSRALAGR---RVPPHVLVNWAVQIARGMHYLHCEA 233
Query: 784 ---IVHRDVKSEN-MLLEP-------NKTLKIADFGVARVEAQNPQDMTGETGTLGYMAP 930
++HRD+KS N +LL+P +KTLKI DFG+AR + Q GT +MAP
Sbjct: 234 LVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQ--MSAAGTYAWMAP 291
Query: 931 EVLEGKPYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSV 1110
EV++ +++ DV+SFGV LWE+ ++PY +++ V L IP CP+
Sbjct: 292 EVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPF 351
Query: 1111 ANIMRRCWDPNPDKRPEMEEVVKLLEAV 1194
A +M CW +P +RP+ +++ LEA+
Sbjct: 352 AQLMADCWAQDPHRRPDFASILQQLEAL 379
>sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase kinase 11 OS=Mus
musculus GN=Map3k11 PE=1 SV=1
Length = 850
Score = 155 bits (391), Expect = 8e-037
Identities = 105/328 (32%), Positives = 164/328 (50%), Gaps = 49/328 (14%)
Frame = +1
Query: 262 WDLNMGGQ----PSSSAAVKSRKSPMQEWEIDLSKLDMNHVLARGTYGTVYRGVYAGQQV 429
W +GGQ PS+ + P + +L + V+ G +G VYRG + G+ V
Sbjct: 85 WAGQVGGQVGIFPSNYVSRGGGPPPCE--VASFQELRLEEVIGIGGFGKVYRGSWRGELV 142
Query: 430 AVKVL--DWGEDGVSTADDLRISFEQEVAVWQKLHHPNVTKFIGASMGTSDLKIPSSSDS 603
AVK D ED TA+ +R QE ++ L HPN+ + +L
Sbjct: 143 AVKAARQDPDEDISVTAESVR----QEARLFAMLAHPNIIALKAVCLEEPNL-------- 190
Query: 604 LGHGNSAHPAKACCVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKA 783
C+V+EY AGG L + L + ++P ++ A+ +ARG+ YLH +A
Sbjct: 191 -------------CLVMEYAAGGPLSRALAGR---RVPPHVLVNWAVQIARGMHYLHCEA 234
Query: 784 ---IVHRDVKSEN-MLLEP-------NKTLKIADFGVARVEAQNPQDMTGETGTLGYMAP 930
++HRD+KS N +LL+P +KTLKI DFG+AR + Q GT +MAP
Sbjct: 235 LVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQ--MSAAGTYAWMAP 292
Query: 931 EVLEGKPYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSV 1110
EV++ +++ DV+SFGV LWE+ ++PY +++ V L IP CP+
Sbjct: 293 EVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPF 352
Query: 1111 ANIMRRCWDPNPDKRPEMEEVVKLLEAV 1194
A +M CW +P +RP+ +++ LEA+
Sbjct: 353 AQLMADCWAQDPHRRPDFASILQQLEAL 380
>sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kinase 11 OS=Rattus
norvegicus GN=Map3k11 PE=2 SV=1
Length = 850
Score = 155 bits (391), Expect = 8e-037
Identities = 105/328 (32%), Positives = 164/328 (50%), Gaps = 49/328 (14%)
Frame = +1
Query: 262 WDLNMGGQ----PSSSAAVKSRKSPMQEWEIDLSKLDMNHVLARGTYGTVYRGVYAGQQV 429
W +GGQ PS+ + P + +L + V+ G +G VYRG + G+ V
Sbjct: 85 WAGQVGGQVGIFPSNYVSRGGGPPPCE--VASFQELRLEEVIGIGGFGKVYRGSWRGELV 142
Query: 430 AVKVL--DWGEDGVSTADDLRISFEQEVAVWQKLHHPNVTKFIGASMGTSDLKIPSSSDS 603
AVK D ED TA+ +R QE ++ L HPN+ + +L
Sbjct: 143 AVKAARQDPDEDISVTAESVR----QEARLFAMLAHPNIIALKAVCLEEPNL-------- 190
Query: 604 LGHGNSAHPAKACCVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKA 783
C+V+EY AGG L + L + ++P ++ A+ +ARG+ YLH +A
Sbjct: 191 -------------CLVMEYAAGGPLSRALAGR---RVPPHVLVNWAVQIARGMHYLHCEA 234
Query: 784 ---IVHRDVKSEN-MLLEP-------NKTLKIADFGVARVEAQNPQDMTGETGTLGYMAP 930
++HRD+KS N +LL+P +KTLKI DFG+AR + Q GT +MAP
Sbjct: 235 LVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQ--MSAAGTYAWMAP 292
Query: 931 EVLEGKPYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSV 1110
EV++ +++ DV+SFGV LWE+ ++PY +++ V L IP CP+
Sbjct: 293 EVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPF 352
Query: 1111 ANIMRRCWDPNPDKRPEMEEVVKLLEAV 1194
A +M CW +P +RP+ +++ LEA+
Sbjct: 353 AQLMADCWAQDPHRRPDFASILQQLEAL 380
>sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kinase MLT OS=Mus
musculus GN=Mltk PE=1 SV=1
Length = 802
Score = 136 bits (342), Expect = 4e-031
Identities = 63/187 (33%), Positives = 112/187 (59%), Gaps = 5/187 (2%)
Frame = +1
Query: 646 VVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKA---IVHRDVKSENM 816
+V EY + G+L ++ ++ ++ ++ A D+A+G+ YLH +A ++HRD+KS N+
Sbjct: 80 IVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNV 139
Query: 817 LLEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLW 996
++ + LKI DFG +R N GT +MAPEV++ P + CD YS+GV LW
Sbjct: 140 VIAADGVLKICDFGASRF--HNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLW 197
Query: 997 EIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVV 1176
E+ ++P+ +++ VV KN R IP CP+S A ++ +CW+ + KRP ++++
Sbjct: 198 EMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQII 257
Query: 1177 KLLEAVN 1197
+LE+++
Sbjct: 258 SILESMS 264
>sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kinase MLT OS=Homo
sapiens GN=MLTK PE=1 SV=2
Length = 800
Score = 136 bits (340), Expect = 7e-031
Identities = 63/187 (33%), Positives = 111/187 (59%), Gaps = 5/187 (2%)
Frame = +1
Query: 646 VVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKA---IVHRDVKSENM 816
+V EY + G+L ++ ++ + ++ A D+A+G+ YLH +A ++HRD+KS N+
Sbjct: 80 IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNV 139
Query: 817 LLEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLW 996
++ + LKI DFG +R N GT +MAPEV++ P + CD YS+GV LW
Sbjct: 140 VIAADGVLKICDFGASRF--HNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLW 197
Query: 997 EIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVV 1176
E+ ++P+ +++ VV KN R IP CP+S A ++ +CW+ + KRP ++++
Sbjct: 198 EMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQII 257
Query: 1177 KLLEAVN 1197
+LE+++
Sbjct: 258 SILESMS 264
>sp|P18160|PYK1_DICDI Dual specificity protein kinase pyk1 OS=Dictyostelium
discoideum GN=splA PE=1 SV=3
Length = 2410
Score = 136 bits (340), Expect = 7e-031
Identities = 83/295 (28%), Positives = 143/295 (48%), Gaps = 32/295 (10%)
Frame = +1
Query: 331 EWEIDLSKLDMNHVLARGTYGTVYRGVYAGQQVAVKVLDWGEDGVSTADDLRISFEQEVA 510
E+EID ++L+ + +G +G V RG + VA+K++ D T L + F+ EV
Sbjct: 2107 EYEIDFNELEFGQTIGKGFFGEVKRGYWRETDVAIKII--YRDQFKTKSSL-VMFQNEVG 2163
Query: 511 VWQKLHHPNVTKFIGASMGTSDLKIPSSSDSLGHGNSAHPAKACCVVVEYVAGGTLKKFL 690
+ KL HPNV +F+GA + ++ +G G+ + F
Sbjct: 2164 ILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGS--------------LRQFLTDHFN 2209
Query: 691 IKKYRTKLPIKDVIQLALDLARGLSYLHSKAIVHRDVKSENMLLEPN------------- 831
+ + + +K + +A + + + I+HRD+ S N+LL+ N
Sbjct: 2210 LLEQNPHIRLKLALDIAKGM--NYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQD 2267
Query: 832 KTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLWEIYCC 1011
KI+DFG++R++ + MT G + YMAPEV +G + K DVYS+G+ L+E+
Sbjct: 2268 IKCKISDFGLSRLKMEQASQMTQSVGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLTS 2327
Query: 1012 DMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVV 1176
D P D +++H +++ RP IP I+ +CWD NPD RP ++++
Sbjct: 2328 DEPQQDMKPMKMAHLAAYESYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQII 2382
>sp|Q05609|CTR1_ARATH Serine/threonine-protein kinase CTR1 OS=Arabidopsis
thaliana GN=CTR1 PE=1 SV=1
Length = 821
Score = 134 bits (335), Expect = 3e-030
Identities = 76/197 (38%), Positives = 115/197 (58%), Gaps = 7/197 (3%)
Frame = +1
Query: 646 VVVEYVAGGTLKKFLIKK-YRTKLPIKDVIQLALDLARGLSYLHSK--AIVHRDVKSENM 816
+V EY++ G+L + L K R +L + + +A D+A+G++YLH++ IVHRD+KS N+
Sbjct: 623 IVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNL 682
Query: 817 LLEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLW 996
L++ T+K+ DFG++R++A GT +MAPEVL +P N K DVYSFGV LW
Sbjct: 683 LVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILW 742
Query: 997 EIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVV 1176
E+ P+ + + A++ AV K R EIP+ VA I+ CW P KRP ++
Sbjct: 743 ELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIM 802
Query: 1177 KLLEAVNTSKGGGMIPP 1227
LL + S +PP
Sbjct: 803 DLLRPLIKS----AVPP 815
>sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 OS=Homo
sapiens GN=MAP3K12 PE=1 SV=2
Length = 859
Score = 123 bits (308), Expect = 4e-027
Identities = 62/188 (32%), Positives = 105/188 (55%), Gaps = 7/188 (3%)
Frame = +1
Query: 631 AKACCVVVEYVAGGTLKKFLIKKYRTKLPIKD--VIQLALDLARGLSYLHSKAIVHRDVK 804
A C+++E+ A G L + L R P+ ++ ++ +A G++YLH I+HRD+K
Sbjct: 183 APCYCILMEFCAQGQLYEVL----RAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLK 238
Query: 805 SENMLLEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFG 984
S NML+ + +KI+DFG ++ E + GT+ +MAPEV+ +P + K D++SFG
Sbjct: 239 SPNMLITYDDVVKISDFGTSK-ELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFG 297
Query: 985 VCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEM 1164
V LWE+ ++PY D + I V +L +P CP ++R+CW+ P RP
Sbjct: 298 VVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSF 357
Query: 1165 EEVVKLLE 1188
+++ L+
Sbjct: 358 RQILLHLD 365
>sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase kinase 12 OS=Mus
musculus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 123 bits (308), Expect = 4e-027
Identities = 62/188 (32%), Positives = 105/188 (55%), Gaps = 7/188 (3%)
Frame = +1
Query: 631 AKACCVVVEYVAGGTLKKFLIKKYRTKLPIKD--VIQLALDLARGLSYLHSKAIVHRDVK 804
A C+++E+ A G L + L R P+ ++ ++ +A G++YLH I+HRD+K
Sbjct: 216 APCYCILMEFCAQGQLYEVL----RAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLK 271
Query: 805 SENMLLEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFG 984
S NML+ + +KI+DFG ++ E + GT+ +MAPEV+ +P + K D++SFG
Sbjct: 272 SPNMLITYDDVVKISDFGTSK-ELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFG 330
Query: 985 VCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEM 1164
V LWE+ ++PY D + I V +L +P CP ++R+CW+ P RP
Sbjct: 331 VVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSF 390
Query: 1165 EEVVKLLE 1188
+++ L+
Sbjct: 391 RQILLHLD 398
>sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kinase 12 OS=Rattus
norvegicus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 123 bits (307), Expect = 5e-027
Identities = 62/188 (32%), Positives = 105/188 (55%), Gaps = 7/188 (3%)
Frame = +1
Query: 631 AKACCVVVEYVAGGTLKKFLIKKYRTKLPIKD--VIQLALDLARGLSYLHSKAIVHRDVK 804
A C+++E+ A G L + L R P+ ++ ++ +A G++YLH I+HRD+K
Sbjct: 216 APCYCILMEFCAQGQLYEVL----RAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLK 271
Query: 805 SENMLLEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFG 984
S NML+ + +KI+DFG ++ E + GT+ +MAPEV+ +P + K D++SFG
Sbjct: 272 SPNMLITYDDVVKISDFGTSK-ELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFG 330
Query: 985 VCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEM 1164
V LWE+ ++PY D + I V +L +P CP ++R+CW+ P RP
Sbjct: 331 VVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNRKPRNRPSF 390
Query: 1165 EEVVKLLE 1188
+++ L+
Sbjct: 391 RQILLHLD 398
>sp|Q23915|KINX_DICDI Probable serine/threonine-protein kinase kinX
OS=Dictyostelium discoideum GN=kinX PE=3 SV=2
Length = 1094
Score = 121 bits (301), Expect = 2e-026
Identities = 72/199 (36%), Positives = 115/199 (57%), Gaps = 10/199 (5%)
Frame = +1
Query: 646 VVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKAIVHRDVKSENMLLE 825
+V E + GG L+ +L K LP +ALD++ +SYLHSK+IVHRD+KS N+L++
Sbjct: 97 IVTELIEGGDLQYYL-KNQSIDLPWFLRANIALDVSLAMSYLHSKSIVHRDLKSTNLLVD 155
Query: 826 PNKTLKIADFGVAR-VEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLWEI 1002
N +K+ DFG AR VE N + MT GT +M+PE++ G Y+ + D++SFG+ L EI
Sbjct: 156 KNWKIKVCDFGFARIVEEDNNKSMT-ICGTDNWMSPEMITGLDYDERSDIFSFGIVLLEI 214
Query: 1003 YCCDMP---YADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEV 1173
P D SF ++ +V L IP CP+S+ ++ C +P+ RP +E+
Sbjct: 215 ISRVKPAPYMRDASFG-LAEDIVRNQL---IPTDCPESLIDLTFNCCSVDPNNRPSFKEI 270
Query: 1174 VKLLEAVNTSKGGGMIPPD 1230
+ L+ + T+ ++ P+
Sbjct: 271 SQTLKQIKTTLDSNIVYPE 289
>sp|A8X775|DLK1_CAEBR Mitogen-activated protein kinase kinase kinase dlk-1
OS=Caenorhabditis briggsae GN=dlk-1 PE=3 SV=1
Length = 857
Score = 113 bits (281), Expect = 5e-024
Identities = 59/178 (33%), Positives = 98/178 (55%), Gaps = 4/178 (2%)
Frame = +1
Query: 643 CVVVEYVAGGTLKKFLIKK-YRTKLPIKDVIQLALDLARGLSYLHSKAIVHRDVKSENML 819
C+V+EY G L L +K T+ D ++ ++A G+ YLH ++HRD+KS N+L
Sbjct: 124 CIVMEYCPKGQLCTVLRQKNLITRQMFSDWVK---EIADGMHYLHQNKVIHRDLKSPNIL 180
Query: 820 LEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLWE 999
+ ++KI DFG + ++ +N M GT+ +MAPE+++ +P N K DVYSFGV LWE
Sbjct: 181 ISAEDSIKICDFGTSHLQKKNDSTMMSFCGTVSWMAPEMIKKEPCNEKVDVYSFGVVLWE 240
Query: 1000 IYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEV 1173
+ + PYA+ + I V L +P+ P+ + ++++C RP +
Sbjct: 241 MLTRETPYANIAQMAIIFGVGTNILNLPMPEEAPRGLVLLIKQCLSQKGRNRPSFSHI 298
>sp|O01700|DLK1_CAEEL Mitogen-activated protein kinase kinase kinase dlk-1
OS=Caenorhabditis elegans GN=dlk-1 PE=1 SV=4
Length = 928
Score = 112 bits (279), Expect = 8e-024
Identities = 58/177 (32%), Positives = 96/177 (54%), Gaps = 2/177 (1%)
Frame = +1
Query: 643 CVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKAIVHRDVKSENMLL 822
C+V+EY + G L L K R + + Q ++A G+ YLH ++HRD+KS N+L+
Sbjct: 197 CIVMEYCSKGQLCTVL--KSRNTITRELFAQWVKEIADGMHYLHQNKVIHRDLKSPNILI 254
Query: 823 EPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLWEI 1002
++KI DFG + ++ + M GT+ +MAPE+++ +P N K DVYSFGV LWE+
Sbjct: 255 SAEDSIKICDFGTSHMQKKMDSTMMSFCGTVSWMAPEMIKKQPCNEKVDVYSFGVVLWEM 314
Query: 1003 YCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEV 1173
+ PYA+ + I V L +P+ P+ + ++++C RP +
Sbjct: 315 LTRETPYANIAQMAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHI 371
>sp|Q03963|E2AK2_MOUSE Interferon-induced, double-stranded RNA-activated protein
kinase OS=Mus musculus GN=Eif2ak2 PE=1 SV=2
Length = 515
Score = 94 bits (232), Expect = 2e-018
Identities = 61/231 (26%), Positives = 110/231 (47%), Gaps = 12/231 (5%)
Frame = +1
Query: 496 EQEVAVWQKLHHPNVTKFIGASMGTSDLKIPSSSDSLGHGNSAHPAKACCVVVEYVAGGT 675
E EV +L+H N+ ++ G S SD+ S + + + +E+ GT
Sbjct: 281 EHEVQALAELNHVNIVQYHSCWEGVDYDPEHSMSDT-----SRYKTRCLFIQMEFCDKGT 335
Query: 676 LKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKAIVHRDVKSENMLLEPNKTLKIADF 855
L++++ + ++K+ ++ L + G+ Y+HSK ++HRD+K N+ L + +KI DF
Sbjct: 336 LEQWMRNRNQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDF 395
Query: 856 GVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLWE-IYCCDMPYADC 1032
G+A + + T TGTL YM+PE L K Y ++ D+++ G+ L E ++ C
Sbjct: 396 GLATALENDGKSRTRRTGTLQYMSPEQLFLKHYGKEVDIFALGLILAELLHTCFTESEKI 455
Query: 1033 SFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLL 1185
F E N +++++ P RPE E++K L
Sbjct: 456 KFFESLRKGDFSN------DIFDNKEKSLLKKLLSEKPKDRPETSEILKTL 500
>sp|Q869N2|PAKB_DICDI Serine/threonine-protein kinase pakB OS=Dictyostelium
discoideum GN=pakB PE=1 SV=1
Length = 852
Score = 94 bits (232), Expect = 2e-018
Identities = 53/195 (27%), Positives = 100/195 (51%), Gaps = 3/195 (1%)
Frame = +1
Query: 646 VVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKAIVHRDVKSENMLLE 825
V +E++ GG L + L + KL + + + +GL+Y+HS+ +HRD+KS+N+LL
Sbjct: 641 VAMEFMGGGCLTEILEQFNSVKLVEAQIAYVCAETLKGLAYIHSQHRIHRDIKSDNILLG 700
Query: 826 PNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLWEIY 1005
+ ++K+ADFG A ++ Q GT +MAPE++ G+ Y+RK D++S G+ E+
Sbjct: 701 SDGSVKLADFGYAAQLTKSKQKRVTIVGTPYWMAPELIRGQNYDRKVDIWSLGIMAMEMA 760
Query: 1006 CCDMPYADCSFAEISHAVVHKNLRPEI--PKCCPQSVANIMRRCWDPNPDKRPEMEEVVK 1179
+ PY + K + P++ + +++C D + + RPE + ++
Sbjct: 761 ESEPPYMSFPPLRALFLITTKGI-PDLKDQNKWSDDFKDFVKKCLDKDVENRPEAKVLLN 819
Query: 1180 LLEAVNTSKGGGMIP 1224
G++P
Sbjct: 820 HPFLKTACNSNGLVP 834
>sp|Q55GV3|PAKC_DICDI Serine/threonine-protein kinase pakC OS=Dictyostelium
discoideum GN=pakC PE=1 SV=1
Length = 493
Score = 88 bits (217), Expect = 1e-016
Identities = 54/180 (30%), Positives = 88/180 (48%), Gaps = 3/180 (1%)
Frame = +1
Query: 646 VVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKAIVHRDVKSENMLLE 825
V +E++ GG L L K+ + + + + L Y+HS +HRD+KS+N+LL
Sbjct: 292 VAMEFMGGGCLTDILEAFDNIKMSEIQIAYVVKETLKALQYIHSLHRIHRDIKSDNILLG 351
Query: 826 PNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLWEIY 1005
++KIADFG A Q Q GT +MAPE++ G Y K D++S G+ + E+
Sbjct: 352 SEGSVKIADFGYAAQLTQKQQKRNTVVGTPYWMAPELIRGHDYGVKVDIWSLGIMMMEMA 411
Query: 1006 CCDMPYADCSFAEISHAVVHKNLRP--EIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVK 1179
+ PY D + K + P E K ++ + +C D N RP+ +++K
Sbjct: 412 EGEPPYMDFPPLRALFLITTKGIPPLKETTK-WSKTFQDFFSKCLDINVANRPDATDLLK 470
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,106,165,710
Number of Sequences: 518415
Number of Extensions: 6106165710
Number of Successful Extensions: 55409465
Number of sequences better than 0.0: 0
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