BLASTX 7.6.2
Query= UN01339 /QuerySize=1114
(1113 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q58D13|DPOA2_BOVIN DNA polymerase alpha subunit B OS=Bos taur... 146 3e-034
sp|Q9VB62|DPOA2_DROME DNA polymerase alpha subunit B OS=Drosophi... 146 3e-034
sp|Q14181|DPOA2_HUMAN DNA polymerase alpha subunit B OS=Homo sap... 146 3e-034
sp|P33611|DPOA2_MOUSE DNA polymerase alpha subunit B OS=Mus musc... 142 5e-033
sp|O89043|DPOA2_RAT DNA polymerase alpha subunit B OS=Rattus nor... 140 2e-032
sp|O74946|DPOA2_SCHPO DNA polymerase alpha subunit B OS=Schizosa... 133 2e-030
sp|Q21625|DPOA2_CAEEL DNA polymerase alpha subunit B OS=Caenorha... 95 9e-019
sp|Q54S08|DPOA2_DICDI DNA polymerase alpha subunit B OS=Dictyost... 89 7e-017
>sp|Q58D13|DPOA2_BOVIN DNA polymerase alpha subunit B OS=Bos taurus GN=POLA2
PE=2 SV=1
Length = 604
Score = 146 bits (368), Expect = 3e-034
Identities = 74/226 (32%), Positives = 130/226 (57%), Gaps = 7/226 (3%)
Frame = -3
Query: 892 PADESHEKSEVSFIIASGPFTTLDNLLFEPLSELLAHAKRKPPQLLVLLGPFVDSDHPEI 713
P +E + + ++A GP+TT D++ F+PL +L+ R P + +L GPF+D+ H ++
Sbjct: 332 PDEEDGDSEQFMVLVACGPYTTSDSITFDPLLDLITIINRDRPDVCILFGPFLDAKHEQV 391
Query: 712 KKGTVDATFSEIFEVEVIRRVQEYVEFMGSEVRVVLVPSIRDANHDFIFPQPPFDIH--I 539
+ + ++F ++F+ + +R + E GS +++VPS+RD +H+ ++PQPPF +
Sbjct: 392 ESCLLTSSFEDVFK-QCLRTIIEGTRSSGS--HLIIVPSLRDVHHEPVYPQPPFSCSDLL 448
Query: 538 PDLEHQITSLSNPGTFEANQVKVGCCTVDVIKQLSVEEMSRNPSGVPTDRLARLASHLLR 359
+ + ++ +S P T N V G + D++ + EE+S S +DR +R+ H+L
Sbjct: 449 REDKKRVRLVSEPCTLSINGVIFGLTSTDLLFHMGAEEIS--SSSGTSDRFSRILRHILT 506
Query: 358 QRSFYPLYPPPESFPYDSSLAPQALQISSIPDILLLPSDITYFVKV 221
QRS+YPLYPP E D Q+ PD+ + PS++ YFVKV
Sbjct: 507 QRSYYPLYPPQEDMAIDYENFYLYAQLPVTPDVFIAPSELRYFVKV 552
Score = 54 bits (129), Expect = 1e-006
Identities = 23/49 (46%), Positives = 37/49 (75%)
Frame = -3
Query: 1105 ERTSGQRVPLDLNRLNQFSIFPGQIVGVEGQNPSGHYLTASKLLDTVPL 959
E +SG ++P+DL+ L ++S+FPGQ+V +EG N +G L A++L + VPL
Sbjct: 279 EHSSGAQIPVDLSELKEYSLFPGQVVVMEGINTTGRKLVATRLYEGVPL 327
>sp|Q9VB62|DPOA2_DROME DNA polymerase alpha subunit B OS=Drosophila melanogaster
GN=DNApol-alpha73 PE=1 SV=2
Length = 609
Score = 146 bits (368), Expect = 3e-034
Identities = 92/259 (35%), Positives = 140/259 (54%), Gaps = 28/259 (10%)
Frame = -3
Query: 898 LTPADESHEKSEVSFIIASGPFTTLDNLLFEPLSELLAHAKRKPPQLLVLLGPFVDSDHP 719
LTPA E+ F++ASGPFT +L +EPL +LL + K P +LVL GPF+D+DH
Sbjct: 348 LTPATPLQIDRELQFVVASGPFTDSTDLFYEPLHDLLKYLKDHRPDVLVLTGPFLDADHK 407
Query: 718 EIKKGTVDATFSEIFEVEVIRRVQEYVEFMGSEVRVVLVPSIRDANHDFIFPQPPFDIHI 539
+ G + TF FE + + +E +GS V++V S +DA ++P PP
Sbjct: 408 MV--GELAETFDTFFE----KMIGGIMESIGSHTAVLVVTSQKDAMALSVYPTPP----- 456
Query: 538 PDLEH---QITSLSNPGTFEANQVKVGCCTVDVIKQLSVEEMSRNPSGVPTDRLARLASH 368
P L + L +P + + +G + DV+ L E + N +R+ R +H
Sbjct: 457 PALRRTYPNLYMLPDPSLVDLDGFTLGVTSTDVVDHLLSHEFAVNAG----ERMHRAINH 512
Query: 367 LLRQRSFYPLYPP-PESFPYDSSLAPQALQISSIPDILLLPSDITYFVKVLSIGEGEDAA 191
L Q SFYPLYPP E YDS LA + Q+ +P++L+LPSD +F+++++
Sbjct: 513 LFHQGSFYPLYPPADEDMAYDSQLALKYAQLKQLPNVLILPSDQRHFIRLVN-------- 564
Query: 190 KCVCVNPGRLAKGEGAGTF 134
C+ +NPGR+A +G GTF
Sbjct: 565 DCLVINPGRVADKKG-GTF 582
Score = 81 bits (198), Expect = 1e-014
Identities = 50/161 (31%), Positives = 84/161 (52%), Gaps = 13/161 (8%)
Frame = -3
Query: 685 SEIFEVEVIRRVQEYVEFMGSEVRVVLVPSIRDANHDFIFPQPPFDIHIPDLEH---QIT 515
+E F+ + + +E +GS V++V S +DA ++P PP P L +
Sbjct: 413 AETFDTFFEKMIGGIMESIGSHTAVLVVTSQKDAMALSVYPTPP-----PALRRTYPNLY 467
Query: 514 SLSNPGTFEANQVKVGCCTVDVIKQLSVEEMSRNPSGVPTDRLARLASHLLRQRSFYPLY 335
L +P + + +G + DV+ L E + N +R+ R +HL Q SFYPLY
Sbjct: 468 MLPDPSLVDLDGFTLGVTSTDVVDHLLSHEFAVNAG----ERMHRAINHLFHQGSFYPLY 523
Query: 334 PP-PESFPYDSSLAPQALQISSIPDILLLPSDITYFVKVLS 215
PP E YDS LA + Q+ +P++L+LPSD +F+++++
Sbjct: 524 PPADEDMAYDSQLALKYAQLKQLPNVLILPSDQRHFIRLVN 564
>sp|Q14181|DPOA2_HUMAN DNA polymerase alpha subunit B OS=Homo sapiens GN=POLA2
PE=1 SV=2
Length = 598
Score = 146 bits (367), Expect = 3e-034
Identities = 78/226 (34%), Positives = 130/226 (57%), Gaps = 9/226 (3%)
Frame = -3
Query: 892 PADESHEKSEVSFIIASGPFTTLDNLLFEPLSELLAHAKRKPPQLLVLLGPFVDSDHPEI 713
P +E + + ++A GP+TT D++ ++PL +L+A P + +L GPF+D+ H ++
Sbjct: 330 PTEEDADFEQSMVLVACGPYTTSDSITYDPLLDLIAVINHDRPDVCILFGPFLDAKHEQV 389
Query: 712 KKGTVDATFSEIFEVEVIRRVQEYVEFMGSEVRVVLVPSIRDANHDFIFPQPPF---DIH 542
+ + + F +IF+ + +R + E GS +V VPS+RD +H+ ++PQPPF D+
Sbjct: 390 ENCLLTSPFEDIFK-QCLRTIIEGTRSSGS--HLVFVPSLRDVHHEPVYPQPPFSYSDLS 446
Query: 541 IPDLEHQITSLSNPGTFEANQVKVGCCTVDVIKQLSVEEMSRNPSGVPTDRLARLASHLL 362
D + Q+ +S P + N V G + D++ L EE+S S +DR +R+ H+L
Sbjct: 447 RED-KKQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEIS--SSSGTSDRFSRILKHIL 503
Query: 361 RQRSFYPLYPPPESFPYDSSLAPQALQISSIPDILLLPSDITYFVK 224
QRS+YPLYPP E D Q+ PD+L++PS++ YFVK
Sbjct: 504 TQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPSELRYFVK 549
Score = 55 bits (131), Expect = 8e-007
Identities = 24/49 (48%), Positives = 37/49 (75%)
Frame = -3
Query: 1105 ERTSGQRVPLDLNRLNQFSIFPGQIVGVEGQNPSGHYLTASKLLDTVPL 959
E +SG ++P+DL+ L ++S+FPGQ+V +EG N +G L A+KL + VPL
Sbjct: 277 EHSSGAQIPVDLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPL 325
>sp|P33611|DPOA2_MOUSE DNA polymerase alpha subunit B OS=Mus musculus GN=Pola2
PE=1 SV=1
Length = 600
Score = 142 bits (357), Expect = 5e-033
Identities = 74/225 (32%), Positives = 125/225 (55%), Gaps = 7/225 (3%)
Frame = -3
Query: 892 PADESHEKSEVSFIIASGPFTTLDNLLFEPLSELLAHAKRKPPQLLVLLGPFVDSDHPEI 713
P +E + ++A GP+TT D++ ++PL +L+A R P + +L GPF+D+ H ++
Sbjct: 330 PTEEEGASEQTMVVVARGPYTTSDSITYDPLLDLIAIINRDQPDVCILFGPFLDAKHEQV 389
Query: 712 KKGTVDATFSEIFEVEVIRRVQEYVEFMGSEVRVVLVPSIRDANHDFIFPQPPFDIHIPD 533
+ + + F ++F+ + +R V E GS +V VPS+RD +H+ ++PQPPF
Sbjct: 390 ENCKLTSPFEDVFK-QCLRTVIEGTRSSGS--HLVFVPSLRDVHHEPVYPQPPFTFSELS 446
Query: 532 LE--HQITSLSNPGTFEANQVKVGCCTVDVIKQLSVEEMSRNPSGVPTDRLARLASHLLR 359
E ++ +S P + N V G + D++ + EE+ S +DR +R+ H+L
Sbjct: 447 REDKKRVQFVSEPCSLSINGVMFGLTSTDLLFHIGAEEIF--SSSGTSDRFSRVLKHILT 504
Query: 358 QRSFYPLYPPPESFPYDSSLAPQALQISSIPDILLLPSDITYFVK 224
QRS+YPLYPP E D Q+ PD+ ++PS++ YFVK
Sbjct: 505 QRSYYPLYPPHEDMAIDYENFYTYAQLPVTPDVFIVPSELRYFVK 549
Score = 55 bits (130), Expect = 1e-006
Identities = 24/49 (48%), Positives = 37/49 (75%)
Frame = -3
Query: 1105 ERTSGQRVPLDLNRLNQFSIFPGQIVGVEGQNPSGHYLTASKLLDTVPL 959
E + G ++P+DL+ L ++S+FPGQ+V +EG N +G LTA+KL + VPL
Sbjct: 277 EHSYGAQIPVDLSELKEYSLFPGQVVIMEGFNTTGRRLTATKLYEGVPL 325
>sp|O89043|DPOA2_RAT DNA polymerase alpha subunit B OS=Rattus norvegicus
GN=Pola2 PE=2 SV=2
Length = 600
Score = 140 bits (351), Expect = 2e-032
Identities = 73/225 (32%), Positives = 127/225 (56%), Gaps = 7/225 (3%)
Frame = -3
Query: 892 PADESHEKSEVSFIIASGPFTTLDNLLFEPLSELLAHAKRKPPQLLVLLGPFVDSDHPEI 713
P +E + + ++A GP+TT D++ ++PL +L++ P + +L GPF+D+ H ++
Sbjct: 330 PTEEEGDFEQTMVLVACGPYTTSDSITYDPLLDLISTINHDRPDVCILFGPFLDAKHEQV 389
Query: 712 KKGTVDATFSEIFEVEVIRRVQEYVEFMGSEVRVVLVPSIRDANHDFIFPQPPFDI-HIP 536
+ + + F +IF+ + +R V E GS +V VPS+RD +H+ ++PQPPF +P
Sbjct: 390 ENCKLTSPFEDIFK-QCLRTVIEGTRSSGS--HLVFVPSLRDVHHEPVYPQPPFTFSELP 446
Query: 535 -DLEHQITSLSNPGTFEANQVKVGCCTVDVIKQLSVEEMSRNPSGVPTDRLARLASHLLR 359
+ + ++ +S P N V G + D++ + EE+ S +DR +R+ H+L
Sbjct: 447 REDKKRVQFVSEPCNLSINGVMFGLTSTDLLFHIGAEEIC--SSSGTSDRFSRILKHILT 504
Query: 358 QRSFYPLYPPPESFPYDSSLAPQALQISSIPDILLLPSDITYFVK 224
QRS+YPLYPP E D Q+ PD+ ++PS++ YFVK
Sbjct: 505 QRSYYPLYPPHEDMAIDYENFYTYAQLPVTPDVFIVPSELRYFVK 549
Score = 55 bits (131), Expect = 8e-007
Identities = 24/49 (48%), Positives = 37/49 (75%)
Frame = -3
Query: 1105 ERTSGQRVPLDLNRLNQFSIFPGQIVGVEGQNPSGHYLTASKLLDTVPL 959
E +SG ++P+D++ L +S+FPGQ+V +EG N +G LTA+KL + VPL
Sbjct: 277 EHSSGAQIPVDVSELKDYSLFPGQVVIMEGFNTTGRRLTATKLYEGVPL 325
>sp|O74946|DPOA2_SCHPO DNA polymerase alpha subunit B OS=Schizosaccharomyces
pombe GN=pol12 PE=1 SV=1
Length = 574
Score = 133 bits (334), Expect = 2e-030
Identities = 92/280 (32%), Positives = 137/280 (48%), Gaps = 18/280 (6%)
Frame = -3
Query: 943 LDLPPAKKQNLDKEVLTPADESHEKSEVSFIIASGPFTTLDNLLFEPLSELLAHAKRKPP 764
L +PP + K+ + +S IASGP++ D+L F PL ++++ + P
Sbjct: 277 LPIPPLPFPSSSKQEHATFVANTNNQPISIYIASGPWSLRDDLSFSPLKSMISYVNKNPV 336
Query: 763 QLLVLLGPFVDSDHPEIKKGTVDATFSEIFEVEVIRRVQEYVEFMGSEVRVVLVPSIRDA 584
L++L GPF+D +H I+ G + T + E RV + + +L+P I DA
Sbjct: 337 DLVILCGPFLDINHILIRTGNITGTSATSLEELFKERVTPILSQL--TCPCILIPHINDA 394
Query: 583 NHDF-IFPQPPFDIHIPDLEHQITSLSNPGTFEANQVKVGCCTVDVIKQLSVEEMSRNPS 407
D +PQ F+ L NP F N V G T D++ S EE+ R PS
Sbjct: 395 ASDHPAWPQDAFNRVALGLPSNFKCFPNPCMFSINDVVFGVSTNDILLHTSREELFRLPS 454
Query: 406 GVPTDRLARLASHLLRQRSFYPLYPP---PESFPYDSSLAPQALQ--ISSIPDILLLPSD 242
+ ARL SH+L QR FYPL+P + P + +A L ++++PDIL+LPSD
Sbjct: 455 --HGNLFARLVSHVLHQRHFYPLFPGGSLEKCNPSNLDIAHLKLGEFLNTMPDILILPSD 512
Query: 241 ITYFVKVLSIGEGEDAAKCVCVNPGRLAKGEGAGTFVELT 122
+ YFVK + V +NPG+ KG GTF +LT
Sbjct: 513 LRYFVK--------NVENVVSLNPGKATKGINLGTFAKLT 544
>sp|Q21625|DPOA2_CAEEL DNA polymerase alpha subunit B OS=Caenorhabditis elegans
GN=div-1 PE=2 SV=3
Length = 581
Score = 95 bits (234), Expect = 9e-019
Identities = 67/226 (29%), Positives = 116/226 (51%), Gaps = 10/226 (4%)
Frame = -3
Query: 883 ESHEKSEVSFIIASGPFTTLDNLLFEPLSELLAHAKRKPPQLLVLLGPFVDSDHPEIKKG 704
E+ E+ F A GP+T DN +E L ELL + P +L+L GPFVD + + K
Sbjct: 316 ETDTTKEIWF--ACGPYTATDNCGYEHLCELLDKVVAEKPDILMLAGPFVDKKNTFLNKP 373
Query: 703 TVDATFSEIFEVEVIRRVQEYVEFMGSEVRVVLVPSI-RDANHDFIFPQPPFDIH--IPD 533
T + T+ + E +++ +V+E +G++ +V++ P+ RD +FP PF + +
Sbjct: 374 TFNITYDNLLE-DLLLKVKE--TLVGTKTQVIIQPNASRDLCVPPVFPSAPFQQNRKLDK 430
Query: 532 LEHQITSLSNPGTFEANQVKVGCCTVDVIKQLSVEEMSRNPSGVPTDRLARLASHLLRQR 353
++ ++ +++P F + V+V + + I+ LS E R+ + DR+ARL+SHLL Q+
Sbjct: 431 IKKELIFVADPCIFRISGVEVAMTSSEPIQALSNTEFHRSANQENIDRVARLSSHLLTQQ 490
Query: 352 SFYPLYPPPESFPYDSSLAPQALQISSIPDILLLPSDITYFVKVLS 215
YPL P P I S P I+ P+ + K ++
Sbjct: 491 CMYPL--EPTEVPASMGDLLDVCCIGSTPHIVFAPTKLAPSAKCVN 534
>sp|Q54S08|DPOA2_DICDI DNA polymerase alpha subunit B OS=Dictyostelium
discoideum GN=polA2 PE=3 SV=2
Length = 623
Score = 89 bits (218), Expect = 7e-017
Identities = 66/218 (30%), Positives = 113/218 (51%), Gaps = 26/218 (11%)
Frame = -3
Query: 874 EKSEVSFIIASGPF----TTLDNLLFEPLSELLAHAKRKPPQLLVLLGPFVDSDHPEIKK 707
E +++ +IASGPF +T D + PL +L K P +L L+GPF+D + IKK
Sbjct: 366 ECGDINVMIASGPFDLQKSTPD---YTPLDDLCNVVSNKKPHILFLMGPFIDESNVHIKK 422
Query: 706 GTVDATFSEIFEVEVIRRVQEYVEFMGSEVRVVLVPSIRDANHDFIFPQPPFDIHIPDLE 527
TFSE+F +++++ + + S +V++VPS+ D +H++IFPQPP+ + +L
Sbjct: 423 --YSETFSELFN-NLMKKLNDNIP---STTKVLIVPSLNDVDHEYIFPQPPY-VPSVNLN 475
Query: 526 HQITSLSNPGTFEANQ-VKVGCCTVDVIKQLSVEEMSRNPSGVPTDRLARLASHLLRQRS 350
I + NP T N+ +G + D+ L + +N P D + + ++ Q +
Sbjct: 476 SNILFVPNPFTLIINESFTIGITSSDIYNNLVSKAHFKN-KHTPED----IFNMIINQNN 530
Query: 349 FYPLYP--PPESFPYDSSLAPQALQISSIPDILLLPSD 242
+YP++P P S Y L PDIL++P +
Sbjct: 531 YYPMHPAQAPISMRYLQHLNFPGF----TPDILVVPKN 564
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,106,165,710
Number of Sequences: 518415
Number of Extensions: 6106165710
Number of Successful Extensions: 55409465
Number of sequences better than 0.0: 0
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