BLASTX 7.6.2
Query= UN02092 /QuerySize=1295
(1294 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q55C17|TECR_DICDI Trans-2,3-enoyl-CoA reductase OS=Dictyostel... 216 3e-055
sp|Q3ZCD7|TECR_BOVIN Trans-2,3-enoyl-CoA reductase OS=Bos taurus... 202 7e-051
sp|Q9NZ01|TECR_HUMAN Trans-2,3-enoyl-CoA reductase OS=Homo sapie... 202 7e-051
sp|Q64232|TECR_RAT Trans-2,3-enoyl-CoA reductase OS=Rattus norve... 201 1e-050
sp|Q9CY27|TECR_MOUSE Trans-2,3-enoyl-CoA reductase OS=Mus muscul... 201 1e-050
sp|Q3SZ89|TECRL_BOVIN Trans-2,3-enoyl-CoA reductase-like OS=Bos ... 168 1e-040
sp|Q5HYJ1|TECRL_HUMAN Trans-2,3-enoyl-CoA reductase-like OS=Homo... 168 1e-040
sp|Q8BFZ1|TECRL_MOUSE Trans-2,3-enoyl-CoA reductase-like OS=Mus ... 164 1e-039
sp|O94511|YN67_SCHPO Putative enoyl reductase C646.07c OS=Schizo... 144 2e-033
sp|Q99190|TSC13_YEAST Enoyl reductase TSC13 OS=Saccharomyces cer... 97 2e-019
sp|Q28891|S5A1_MACFA 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=... 70 3e-011
sp|P18405|S5A1_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=... 67 3e-010
sp|P24008|S5A1_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Ra... 62 6e-009
sp|Q68FF9|S5A1_MOUSE 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=... 62 8e-009
sp|A5PJS2|S5A1_BOVIN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=... 62 1e-008
sp|P31214|S5A2_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=Ra... 53 5e-006
>sp|Q55C17|TECR_DICDI Trans-2,3-enoyl-CoA reductase OS=Dictyostelium discoideum
GN=gpsn2 PE=3 SV=1
Length = 300
Score = 216 bits (549), Expect = 3e-055
Identities = 123/299 (41%), Positives = 165/299 (55%), Gaps = 13/299 (4%)
Frame = +2
Query: 152 RSGREVLKAPLDLPDSATVADLQEAFHKRAKKFYPSRQRLTLPVAPGSKDKPVVLNSKKS 331
RS +EV S TV +L++ + + R RL +P K S
Sbjct: 10 RSKKEV--GSFSTSSSTTVGELKKQISSKT-RLGTERIRLAVPSKTSKLPNAFEALGKDS 66
Query: 332 LKEYCDGNTDSLTVVFKDLGAQVSYRTLFFFEYLGPLLIYPVFYYFPVYKYLGYGEDRVI 511
DS T+ FKDLG Q+S+ +F EY GPL +YP+FY+ L YG D
Sbjct: 67 DLVSKHVGADS-TLYFKDLGPQISWSLVFICEYAGPLFVYPIFYFL---SNLIYGTDSPK 122
Query: 512 HPVQTYAMYYWCFHYFKRIMETFFVHRFSHATSPIGNVFRNCAYYWTFGAYIAYYVNHPL 691
Q A+ + HY KRI ET FVHRFSH T PI N+F+NC+YYW A ++Y+VNHPL
Sbjct: 123 SFAQKVALVCYSLHYIKRIYETIFVHRFSHGTMPIFNLFKNCSYYWGCTAMVSYFVNHPL 182
Query: 692 YTPVSDLQMKIGFGFGLVCQVANFYCHILLKNLRDPSGAGGYQIPRGFLFNIVTCANYTT 871
YT ++ +G G ++ +V N+ CHI L+NLR P+G+ +IPRG LF V+C NYT
Sbjct: 183 YTEAPIERVYLGLGLWIIGEVFNYICHIQLRNLR-PAGSTERKIPRGLLFEFVSCPNYTV 241
Query: 872 EIYQWLGFNIATQTVAGYVFLAVAALIMTNWALGKHSRLRKIFDGKDGKPKYPRRWVIL 1048
EI W+GF+I TQT+ ++F + A M WA+GKH R RK F KYP+ IL
Sbjct: 242 EILSWIGFSILTQTLTSWIFALMGAAQMWIWAVGKHRRYRKEFG-----DKYPKSRKIL 295
>sp|Q3ZCD7|TECR_BOVIN Trans-2,3-enoyl-CoA reductase OS=Bos taurus GN=TECR PE=2
SV=1
Length = 308
Score = 202 bits (512), Expect = 7e-051
Identities = 121/297 (40%), Positives = 167/297 (56%), Gaps = 26/297 (8%)
Frame = +2
Query: 200 ATVADLQEAFHKRAKKFYPSRQRLTL-PVAPGSKDKPVVLNSKKSLKEYCDGNTDSLTVV 376
AT+A+++ F K ++YP+RQ L L P KD+ V L++ G T T+
Sbjct: 27 ATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLKDEDV-------LQKLPVGTT--ATLY 77
Query: 377 FKDLGAQVSYRTLFFFEYLGPLLIYPVFYYFPVYKY-LGYGEDRVIHPVQTYAMYYWCFH 553
F+DLGAQ+S+ T+F EY GPL IY +FY+ + Y Y H V A FH
Sbjct: 78 FRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACICHSFH 137
Query: 554 YFKRIMETFFVHRFSHATSPIGNVFRNCAYYWTFGAYIAYYVNHPLYTP--VSDLQMKIG 727
Y KR++ET FVHRFSH T P+ N+F+NC YYW F A++AYY+NHPLYTP Q+K+
Sbjct: 138 YIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLA 197
Query: 728 FGFGLVCQVANFYCHILLKNLRDPSGAGGYQIPR------GFLFNIVTCANYTTEIYQWL 889
++CQ+ NF H+ L++LR P+G+ +IP +LF +V+C NYT E+ W+
Sbjct: 198 LAIFVICQLGNFSIHMALRDLR-PAGSKTRKIPYPTRNPFTWLFLLVSCPNYTYEVGSWI 256
Query: 890 GFNIATQTVAGYVFLAVAALIMTNWALGKHSRLRKIFDGKDGKPKYPRRWVILPPFL 1060
GF I TQ + +F V MT WA GKH K F YP + + PFL
Sbjct: 257 GFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEF------RDYPPLRMPIIPFL 307
>sp|Q9NZ01|TECR_HUMAN Trans-2,3-enoyl-CoA reductase OS=Homo sapiens GN=TECR PE=1
SV=1
Length = 308
Score = 202 bits (512), Expect = 7e-051
Identities = 122/298 (40%), Positives = 169/298 (56%), Gaps = 28/298 (9%)
Frame = +2
Query: 200 ATVADLQEAFHKRAKKFYPSRQRLTL-PVAPGSKDKPVVLNSKKSLKEYCDGNTDSLTVV 376
AT+A+++ F K ++YP+RQ L L P KD+ V L++ G T T+
Sbjct: 27 ATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLKDEDV-------LQKLPVGTT--ATLY 77
Query: 377 FKDLGAQVSYRTLFFFEYLGPLLIYPVFYYFPVYKYLGYGEDRVI--HPVQTYAMYYWCF 550
F+DLGAQ+S+ T+F EY GPL IY +FY+ + Y G+ D H V A F
Sbjct: 78 FRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIY-GHKYDFTSSRHTVVHLACICHSF 136
Query: 551 HYFKRIMETFFVHRFSHATSPIGNVFRNCAYYWTFGAYIAYYVNHPLYTP--VSDLQMKI 724
HY KR++ET FVHRFSH T P+ N+F+NC YYW F A++AYY+NHPLYTP Q+K+
Sbjct: 137 HYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKL 196
Query: 725 GFGFGLVCQVANFYCHILLKNLRDPSGAGGYQIPR------GFLFNIVTCANYTTEIYQW 886
++CQ+ NF H+ L++LR P+G+ +IP +LF +V+C NYT E+ W
Sbjct: 197 ALAIFVICQLGNFSIHMALRDLR-PAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSW 255
Query: 887 LGFNIATQTVAGYVFLAVAALIMTNWALGKHSRLRKIFDGKDGKPKYPRRWVILPPFL 1060
+GF I TQ + +F V MT WA GKH K F YP + + PFL
Sbjct: 256 IGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEF------RDYPPLRMPIIPFL 307
>sp|Q64232|TECR_RAT Trans-2,3-enoyl-CoA reductase OS=Rattus norvegicus GN=Tecr
PE=2 SV=1
Length = 308
Score = 201 bits (510), Expect = 1e-050
Identities = 121/297 (40%), Positives = 167/297 (56%), Gaps = 26/297 (8%)
Frame = +2
Query: 200 ATVADLQEAFHKRAKKFYPSRQRLTL-PVAPGSKDKPVVLNSKKSLKEYCDGNTDSLTVV 376
AT+++++ F K ++YP+RQ L L P KD+ V L++ G T T+
Sbjct: 27 ATISEIKTLFTKTHPQWYPARQSLRLDPKGKSLKDEDV-------LQKLPVGTT--ATLY 77
Query: 377 FKDLGAQVSYRTLFFFEYLGPLLIYPVFYYFPVYKY-LGYGEDRVIHPVQTYAMYYWCFH 553
F+DLGAQ+S+ T+F EY GPL IY +FY+ + Y Y H V A FH
Sbjct: 78 FRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFH 137
Query: 554 YFKRIMETFFVHRFSHATSPIGNVFRNCAYYWTFGAYIAYYVNHPLYTP--VSDLQMKIG 727
Y KR++ET FVHRFSH T P+ N+F+NC YYW F A++AYY+NHPLYTP Q+K+
Sbjct: 138 YIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLA 197
Query: 728 FGFGLVCQVANFYCHILLKNLRDPSGAGGYQIPR------GFLFNIVTCANYTTEIYQWL 889
++CQ+ NF H+ L++LR P+G+ +IP +LF +V+C NYT E+ W+
Sbjct: 198 LAIFVICQLGNFSIHMALRDLR-PAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWI 256
Query: 890 GFNIATQTVAGYVFLAVAALIMTNWALGKHSRLRKIFDGKDGKPKYPRRWVILPPFL 1060
GF I TQ V +F V MT WA GKH K F YP + + PFL
Sbjct: 257 GFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEF------RDYPPLRMPIIPFL 307
>sp|Q9CY27|TECR_MOUSE Trans-2,3-enoyl-CoA reductase OS=Mus musculus GN=Tecr PE=1
SV=1
Length = 308
Score = 201 bits (509), Expect = 1e-050
Identities = 121/297 (40%), Positives = 167/297 (56%), Gaps = 26/297 (8%)
Frame = +2
Query: 200 ATVADLQEAFHKRAKKFYPSRQRLTL-PVAPGSKDKPVVLNSKKSLKEYCDGNTDSLTVV 376
AT+++++ F K ++YP+RQ L L P KD+ V L++ G T T+
Sbjct: 27 ATISEIKTLFTKTHPQWYPARQSLRLDPKGKSLKDEDV-------LQKLPVGTT--ATLY 77
Query: 377 FKDLGAQVSYRTLFFFEYLGPLLIYPVFYYFPVYKY-LGYGEDRVIHPVQTYAMYYWCFH 553
F+DLGAQ+S+ T+F EY GPL IY +FY+ + Y Y H V A FH
Sbjct: 78 FRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFH 137
Query: 554 YFKRIMETFFVHRFSHATSPIGNVFRNCAYYWTFGAYIAYYVNHPLYTP--VSDLQMKIG 727
Y KR++ET FVHRFSH T P+ N+F+NC YYW F A++AYY+NHPLYTP Q+K+
Sbjct: 138 YIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLA 197
Query: 728 FGFGLVCQVANFYCHILLKNLRDPSGAGGYQIPR------GFLFNIVTCANYTTEIYQWL 889
++CQ+ NF H+ L++LR P+G+ +IP +LF +V+C NYT E+ W+
Sbjct: 198 LAVFVICQLGNFSIHMALRDLR-PAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWI 256
Query: 890 GFNIATQTVAGYVFLAVAALIMTNWALGKHSRLRKIFDGKDGKPKYPRRWVILPPFL 1060
GF I TQ V +F V MT WA GKH K F YP + + PFL
Sbjct: 257 GFAILTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEF------RDYPPLRMPIIPFL 307
>sp|Q3SZ89|TECRL_BOVIN Trans-2,3-enoyl-CoA reductase-like OS=Bos taurus GN=TECRL
PE=2 SV=1
Length = 363
Score = 168 bits (424), Expect = 1e-040
Identities = 104/298 (34%), Positives = 155/298 (52%), Gaps = 29/298 (9%)
Frame = +2
Query: 200 ATVADLQEAFHKRAKKFYPSRQRLTLP-VAPGSKDKPVVLNSKKSLKEYCDGNTDSLTVV 376
+T+ D+++ FHK ++YPSR L L P KD + + S +T+
Sbjct: 83 STIHDVKQKFHKACPQWYPSRVGLQLERGGPFLKDNLTIQSVAAS---------SIVTLY 133
Query: 377 FKDLGAQVSYRTLFFFEYLGPLLIYPVFYYFPVYKY-LGYGEDRVIHPVQTYAMYYWCFH 553
F DLG QVS+ T+F EY GPLLIY +FY Y Y + R+ HPV A + C H
Sbjct: 134 FTDLGQQVSWTTVFLAEYTGPLLIYLLFYLRIPYIYNMKESSRRLCHPVVHLACFCHCIH 193
Query: 554 YFKRIMETFFVHRFSHATSPIGNVFRNCAYYWTFGAYIAYYVNHPLYTPVS--DLQMKIG 727
Y + ++ET FVH+ S + + N+ ++CA+YW F ++IAYY+NHP YTP S Q+ I
Sbjct: 194 YIRYLLETLFVHKVSSGHTSLKNLLKSCAFYWGFTSWIAYYINHPRYTPPSFGYRQVAIS 253
Query: 728 FGFGLVCQVANFYCHILLKNLRDPSGAGGYQI-------PRGFLFNIVTCANYTTEIYQW 886
L+C+ N + +++L + PS G P ++F +V+C NYT EI W
Sbjct: 254 AINFLICEAGNHFINVVLSH---PSHTGNNACFPSPNYNPFTWMFFLVSCPNYTYEIGSW 310
Query: 887 LGFNIATQTVAGYVFLAVAALIMTNWALGKHSRLRKIFDGKDGKPKYPRRWVILPPFL 1060
+ F I TQT+ +F + ++ M+ WA KH K F Y R + PF+
Sbjct: 311 ISFTIMTQTLPVGIFTLLMSIQMSLWAKKKHKIYLKKFS------SYMHRKSAMIPFI 362
>sp|Q5HYJ1|TECRL_HUMAN Trans-2,3-enoyl-CoA reductase-like OS=Homo sapiens
GN=TECRL PE=2 SV=1
Length = 363
Score = 168 bits (423), Expect = 1e-040
Identities = 96/269 (35%), Positives = 146/269 (54%), Gaps = 17/269 (6%)
Frame = +2
Query: 197 SATVADLQEAFHKRAKKFYPSRQRLTLPV-APGSKDKPVVLNSKKSLKEYCDGNTDSLTV 373
S+T+ D+++ FHK K+YPSR L L P KD + + S +T+
Sbjct: 82 SSTIHDVKQKFHKACPKWYPSRVGLQLECGGPFLKDYITIQSIAAS---------SIVTL 132
Query: 374 VFKDLGAQVSYRTLFFFEYLGPLLIYPVFYYFPVYKYLG-YGEDRVIHPVQTYAMYYWCF 550
DLG QVS+ T+F EY GPLLIY +FY Y G R+ HPV A + C
Sbjct: 133 YATDLGQQVSWTTVFLAEYTGPLLIYLLFYLRIPCIYDGKESARRLRHPVVHLACFCHCI 192
Query: 551 HYFKRIMETFFVHRFSHATSPIGNVFRNCAYYWTFGAYIAYYVNHPLYTPVS--DLQMKI 724
HY + ++ET FVH+ S +P+ N+ +CA+YW F ++IAYY+NHPLYTP S + Q+ +
Sbjct: 193 HYIRYLLETLFVHKVSAGHTPLKNLIMSCAFYWGFTSWIAYYINHPLYTPPSFGNRQITV 252
Query: 725 GFGFGLVCQVANFYCHILLKNLRDPSGAGGYQIPR----GFLFNIVTCANYTTEIYQWLG 892
L+C+ N + +++L + + P ++F +V+C NYT EI W+
Sbjct: 253 SAINFLICEAGNHFINVMLSHPNHTGNNACFPSPNYNPFTWMFFLVSCPNYTYEIGSWIS 312
Query: 893 FNIATQTVAGYVFLAVAALIMTNWALGKH 979
F + TQT+ +F + ++ M+ WA KH
Sbjct: 313 FTVMTQTLPVGIFTLLMSIQMSLWAQKKH 341
>sp|Q8BFZ1|TECRL_MOUSE Trans-2,3-enoyl-CoA reductase-like OS=Mus musculus
GN=Tecrl PE=2 SV=1
Length = 361
Score = 164 bits (415), Expect = 1e-039
Identities = 98/277 (35%), Positives = 145/277 (52%), Gaps = 17/277 (6%)
Frame = +2
Query: 197 SATVADLQEAFHKRAKKFYPSRQRLTLPV-APGSKDKPVVLNSKKSLKEYCDGNTDSLTV 373
++T+ D+++ FHK K+YPSR L L P +D V + S +T+
Sbjct: 80 TSTIHDVKQKFHKACPKWYPSRIGLQLEYGGPYLRDYITVQSVAAS---------SIITL 130
Query: 374 VFKDLGAQVSYRTLFFFEYLGPLLIYPVFYYFPVYKYLGYGEDR-VIHPVQTYAMYYWCF 550
F DLG QV + T+F EY GPLLIY +FY Y Y R HPV A + C
Sbjct: 131 YFTDLGQQVGWTTVFLAEYSGPLLIYLLFYLRSSYIYDVKESTRWPRHPVVHLAFFCHCI 190
Query: 551 HYFKRIMETFFVHRFSHATSPIGNVFRNCAYYWTFGAYIAYYVNHPLYTPVS--DLQMKI 724
HY + ++ET FVH+ S SP+ N+ + CA+YW F +++AYY+NHP YTP S + Q+ +
Sbjct: 191 HYIRLLLETLFVHKVSTGHSPMKNLIKGCAFYWGFTSWMAYYINHPRYTPPSFGNRQVIV 250
Query: 725 GFGFGLVCQVANFYCHILLKNLRDPSGAGGYQIPR----GFLFNIVTCANYTTEIYQWLG 892
L C+ N + + +L + + P +LF +V+C NYT EI W+
Sbjct: 251 SAINFLFCEAGNHFINTVLAHPNHTGSNACFPSPNYNPFTWLFFLVSCPNYTYEIGSWIS 310
Query: 893 FNIATQTVAGYVFLAVAALIMTNWALGKHSRLRKIFD 1003
F + TQT+ +F + + M+ WA KH RK F+
Sbjct: 311 FTVMTQTLPVGIFTILMTIQMSLWARKKHKIYRKKFN 347
>sp|O94511|YN67_SCHPO Putative enoyl reductase C646.07c OS=Schizosaccharomyces
pombe GN=SPBC646.07c PE=2 SV=1
Length = 295
Score = 144 bits (362), Expect = 2e-033
Identities = 97/270 (35%), Positives = 149/270 (55%), Gaps = 27/270 (10%)
Frame = +2
Query: 263 QRLTLPVAPGSKDKPVVLNSKKSLKEYCDGNTDSLTVVFKDLGAQVSYRTLFFFEYLGPL 442
+RL A G+ L +L++Y G T+ KDLG Q+ +RT+F EYLGPL
Sbjct: 43 ERLRFSTADGT-----TLLPNTTLRKY--GVGPGATIWVKDLGPQIGWRTVFMIEYLGPL 95
Query: 443 LIYPVFYYFPVYKYLGYGEDRVIHPVQTYAMYYWCFHYFKRIMETFFVHRFSHATSPIGN 622
+I+ ++ YK++ Y +D + Q A H+ KR E+ FVHRFS AT P+ N
Sbjct: 96 VIH--LFFILNYKWI-YRKDYNLCLNQKIAFVLVMLHFMKREYESIFVHRFSLATMPLRN 152
Query: 623 VFRNCAYYWTF-GAYIAYYVNHPLYT-----PVSDLQMKIGFGFGLVCQVANFYCHILLK 784
+F+NCA+Y G ++AY++ P + P L + +G+ F + ++NF HI+L+
Sbjct: 153 IFKNCAHYHLLSGLFLAYFIYGPWHANDYIKPNHLLFLIVGWAFAV---LSNFRTHIILR 209
Query: 785 NLRDPSGAGGYQIPRGFLFNIVTCANYTTEIYQWLGFNIATQTVAGYVFLAVAALIMTNW 964
+LR P+G+ IP G+ FN+V+ NY E WL F + T++ A ++FL V + M W
Sbjct: 210 DLR-PAGSKKRVIPTGYGFNLVSFPNYFFESLGWLFFALLTKSWASWIFLFVGSAQMFVW 268
Query: 965 ALGKHSRLRKIFDGKDGKPKYPR-RWVILP 1051
A KH+R K F P YPR R +++P
Sbjct: 269 AKKKHARYLKEF------PNYPRSRKIMIP 292
>sp|Q99190|TSC13_YEAST Enoyl reductase TSC13 OS=Saccharomyces cerevisiae
GN=TSC13 PE=1 SV=1
Length = 310
Score = 97 bits (240), Expect = 2e-019
Identities = 55/143 (38%), Positives = 78/143 (54%), Gaps = 9/143 (6%)
Frame = +2
Query: 257 SRQRLTLPVAPGSKDKPVVLNSKKSLKEYCDGNTDSLTVVFKDLGAQVSYRTLFFFEYLG 436
S+ R+ L SK PV+ S+ +E D DS+ KDLG Q+S+R +FF EYLG
Sbjct: 40 SKYRIRLTYKKESKQVPVI--SESFFQEEAD---DSMEFFIKDLGPQISWRLVFFCEYLG 94
Query: 437 PLLIYPVFYY---FPVYKYLGYGEDRVIHPVQTYAMYYWCF-HYFKRIMETFFVHRFSHA 604
P+L++ +FYY P + +P Y+ HY KR+ ET FVH+FS A
Sbjct: 95 PVLVHSLFYYLSTIPTVVDRWHSASSDYNPFLNRVAYFLILGHYGKRLFETLFVHQFSLA 154
Query: 605 TSPIGNVFRNCAYYWTFGAYIAY 673
T PI N+F+NC +YW I++
Sbjct: 155 TMPIFNLFKNCFHYWVLSGLISF 177
>sp|Q28891|S5A1_MACFA 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Macaca
fascicularis GN=SRD5A1 PE=1 SV=1
Length = 263
Score = 70 bits (170), Expect = 3e-011
Identities = 50/158 (31%), Positives = 76/158 (48%), Gaps = 7/158 (4%)
Frame = +2
Query: 470 PVYKYLGYGEDRVIHPVQTYAMYYWCFHYFKRIMETFFVHRFSHATSPIGNVFRNCAYYW 649
P+Y+Y R+ + + HY R + F+ R + +
Sbjct: 71 PLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTM--AIMFC 128
Query: 650 TFGAYI-AYYVNH-PLYTP--VSDLQMKIGFGFGLVCQVANFYCHILLKNLRDPSGAGGY 817
TF Y+ + Y++H +Y V+D + IGFG L + N + +L+NLR P G GY
Sbjct: 129 TFNGYLQSRYLSHWAVYADDWVTDPRFLIGFGLWLAGMLINIHSDHILRNLRKP-GDTGY 187
Query: 818 QIPRGFLFNIVTCANYTTEIYQWLGFNIATQTVAGYVF 931
+IPRG LF VT ANY EI +W G+ +A+ +V G F
Sbjct: 188 KIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAF 225
>sp|P18405|S5A1_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Homo sapiens
GN=SRD5A1 PE=1 SV=1
Length = 259
Score = 67 bits (161), Expect = 3e-010
Identities = 38/101 (37%), Positives = 54/101 (53%), Gaps = 1/101 (0%)
Frame = +2
Query: 701 VSDLQMKIGFGFGLVCQVANFYCHILLKNLRDPSGAGGYQIPRGFLFNIVTCANYTTEIY 880
V+D + IGFG L + N + +L+NLR P G GY+IPRG LF VT ANY EI
Sbjct: 146 VTDPRFLIGFGLWLTGMLINIHSDHILRNLRKP-GDTGYKIPRGGLFEYVTAANYFGEIM 204
Query: 881 QWLGFNIATQTVAGYVFLAVAALIMTNWALGKHSRLRKIFD 1003
+W G+ +A+ +V G F ++ A H + F+
Sbjct: 205 EWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFE 245
>sp|P24008|S5A1_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Rattus norvegicus
GN=Srd5a1 PE=1 SV=2
Length = 259
Score = 62 bits (150), Expect = 6e-009
Identities = 32/69 (46%), Positives = 43/69 (62%), Gaps = 1/69 (1%)
Frame = +2
Query: 725 GFGFGLVCQVANFYCHILLKNLRDPSGAGGYQIPRGFLFNIVTCANYTTEIYQWLGFNIA 904
GF LV V N + +L+NLR P G GY+IPRG LF V+ ANY E+ +W GF +A
Sbjct: 154 GFALWLVGMVINIHSDHILRNLRKP-GETGYKIPRGGLFEYVSAANYFGELVEWCGFALA 212
Query: 905 TQTVAGYVF 931
+ ++ G VF
Sbjct: 213 SWSLQGVVF 221
>sp|Q68FF9|S5A1_MOUSE 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Mus musculus
GN=Srd5a1 PE=2 SV=2
Length = 255
Score = 62 bits (149), Expect = 8e-009
Identities = 32/69 (46%), Positives = 43/69 (62%), Gaps = 1/69 (1%)
Frame = +2
Query: 725 GFGFGLVCQVANFYCHILLKNLRDPSGAGGYQIPRGFLFNIVTCANYTTEIYQWLGFNIA 904
GF LV V N + +L+NLR P G GY+IPRG LF V+ ANY E+ +W GF +A
Sbjct: 150 GFALWLVGMVINIHSDHILRNLRKP-GETGYKIPRGGLFEYVSSANYFGELVEWCGFALA 208
Query: 905 TQTVAGYVF 931
+ ++ G VF
Sbjct: 209 SWSLQGVVF 217
>sp|A5PJS2|S5A1_BOVIN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Bos taurus
GN=SRD5A1 PE=2 SV=1
Length = 257
Score = 62 bits (148), Expect = 1e-008
Identities = 35/124 (28%), Positives = 62/124 (50%), Gaps = 5/124 (4%)
Frame = +2
Query: 644 YWTFGAYI--AYYVNHPLYTP--VSDLQMKIGFGFGLVCQVANFYCHILLKNLRDPSGAG 811
+ T+ Y+ Y + +Y +SD + G L+ + N + +L+NLR P G
Sbjct: 121 FCTYNGYLQSRYLSQYAVYADDWLSDPRFLTGSALWLIGMLINIHSDHVLRNLRKP-GET 179
Query: 812 GYQIPRGFLFNIVTCANYTTEIYQWLGFNIATQTVAGYVFLAVAALIMTNWALGKHSRLR 991
GY+IPRG LF ++ ANY E+ +W G+ +A+ ++ G+ F ++ A H
Sbjct: 180 GYKIPRGGLFEYISAANYFGEVVEWCGYALASWSIQGWAFAVFTFCVLFTRAQQHHKWYH 239
Query: 992 KIFD 1003
+ F+
Sbjct: 240 EKFE 243
>sp|P31214|S5A2_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=Rattus norvegicus
GN=Srd5a2 PE=1 SV=1
Length = 254
Score = 53 bits (125), Expect = 5e-006
Identities = 44/155 (28%), Positives = 67/155 (43%), Gaps = 10/155 (6%)
Frame = +2
Query: 551 HYFKRIMETFFVHRFSHATSPIGNV--FRNCAYYWTFGAYIAYYVNHPLYTP---VSDLQ 715
HYF R F++ P V R A+ G AYY+ + P +D++
Sbjct: 90 HYFHRT----FIYSLLTRGRPFPAVLFLRATAFCIGNGLLQAYYLVYCAEYPEEWYTDVR 145
Query: 716 MKIGFGFGLVCQVANFYCHILLKNLRDPSGAGGYQIPRGFLFNIVTCANYTTEIYQWLGF 895
G ++ N + L+ LR P G Y+IPRG LF V+ AN+ EI +W+G+
Sbjct: 146 FSFGVFLFILGMGINIHSDYTLRQLRKP-GEVIYRIPRGGLFTYVSGANFLGEIIEWIGY 204
Query: 896 NIATQTVAGYVFLAVAALIMTNWALGKHSRLRKIF 1000
+AT +V + F + A H K+F
Sbjct: 205 ALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMF 239
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,590,037,747
Number of Sequences: 518415
Number of Extensions: 9590037747
Number of Successful Extensions: 72030089
Number of sequences better than 0.0: 0
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