BLASTX 7.6.2
Query= UN02280 /QuerySize=1186
(1185 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9NQT4|EXOS5_HUMAN Exosome complex exonuclease RRP46 OS=Homo ... 141 1e-032
sp|Q9CRA8|EXOS5_MOUSE Exosome complex exonuclease RRP46 OS=Mus m... 138 1e-031
sp|Q8VYR2|NUDT9_ARATH Nudix hydrolase 9 OS=Arabidopsis thaliana ... 122 8e-027
sp|O42872|RRP41_SCHPO Exosome complex component ski6 OS=Schizosa... 57 3e-007
sp|Q8ZVM9|ECX1_PYRAE Probable exosome complex exonuclease 1 OS=P... 55 9e-007
sp|A4WM67|ECX1_PYRAR Probable exosome complex exonuclease 1 OS=P... 55 1e-006
sp|Q17533|EXOS4_CAEEL Putative exosome complex exonuclease RRP41... 54 2e-006
sp|A3MUP1|ECX1_PYRCJ Probable exosome complex exonuclease 1 OS=P... 54 3e-006
sp|B1Y978|ECX1_THENV Probable exosome complex exonuclease 1 OS=T... 54 3e-006
sp|O59223|ECX1_PYRHO Probable exosome complex exonuclease 1 OS=P... 53 3e-006
sp|O29757|ECX1_ARCFU Probable exosome complex exonuclease 1 OS=A... 53 4e-006
sp|A9A5C9|ECX1_NITMS Probable exosome complex exonuclease 1 OS=N... 52 7e-006
sp|A8WQQ5|EXOS4_CAEBR Putative exosome complex exonuclease RRP41... 52 1e-005
>sp|Q9NQT4|EXOS5_HUMAN Exosome complex exonuclease RRP46 OS=Homo sapiens
GN=EXOSC5 PE=1 SV=1
Length = 235
Score = 141 bits (354), Expect = 1e-032
Identities = 74/152 (48%), Positives = 98/152 (64%), Gaps = 1/152 (0%)
Frame = +1
Query: 112 LRPLACSRNILHRPHGSASWSQGDTKVLV-VYGPKPVTRKNENPEKACFEVIWKPKSGQI 288
LR AC +N+L RP GSAS+ QGDT VL VYGP V E KA EVI +PK G
Sbjct: 28 LRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLP 87
Query: 289 GKAEKEYEMILKKTIQSICVLTVNPNTTTSVIIQVVHDDGSLLPCAINAACAALVDAGIP 468
G AEK E +++ T +++ + T++P T+ +V++QVV D GSLL C +NAAC ALVDAG+P
Sbjct: 88 GVAEKSRERLIRNTCEAVVLGTLHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVP 147
Query: 469 MKHLAVAICCCLADSGYVVLDPNKLEEKKMTA 564
M+ L + C L G +VLDP +EK+ A
Sbjct: 148 MRALFCGVACALDSDGTLVLDPTSKQEKEARA 179
>sp|Q9CRA8|EXOS5_MOUSE Exosome complex exonuclease RRP46 OS=Mus musculus
GN=Exosc5 PE=1 SV=1
Length = 235
Score = 138 bits (346), Expect = 1e-031
Identities = 73/152 (48%), Positives = 97/152 (63%), Gaps = 1/152 (0%)
Frame = +1
Query: 112 LRPLACSRNILHRPHGSASWSQGDTKVLV-VYGPKPVTRKNENPEKACFEVIWKPKSGQI 288
LR AC +N+L RP GSAS+ QGDT VL VYGP V E KA EVI +PK G
Sbjct: 28 LRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLP 87
Query: 289 GKAEKEYEMILKKTIQSICVLTVNPNTTTSVIIQVVHDDGSLLPCAINAACAALVDAGIP 468
G AEK E +++ T +++ + ++P T+ +V++QVV D GSLL C +NAAC ALVDAG+P
Sbjct: 88 GVAEKSRERLVRNTCEAVVLGALHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVP 147
Query: 469 MKHLAVAICCCLADSGYVVLDPNKLEEKKMTA 564
M+ L + C L G +VLDP +EK+ A
Sbjct: 148 MRALFCGVTCALDSDGNLVLDPTTKQEKEARA 179
>sp|Q8VYR2|NUDT9_ARATH Nudix hydrolase 9 OS=Arabidopsis thaliana GN=NUDT9 PE=2
SV=1
Length = 311
Score = 122 bits (304), Expect = 8e-027
Identities = 55/68 (80%), Positives = 62/68 (91%)
Frame = -1
Query: 1185 FFFIKCSHHSDDIPKLYSSAEDGFGSTQLHTVSLEELKTMVSRMPGCHHGGFALYQLMLQ 1006
FF++KCSHHSDDI +LYSSAEDGF STQLHTVSL+ELK M SRMPGCHHGGFALY+LMLQ
Sbjct: 239 FFYLKCSHHSDDIQRLYSSAEDGFESTQLHTVSLDELKMMTSRMPGCHHGGFALYELMLQ 298
Query: 1005 RLQSTNAT 982
RL++T T
Sbjct: 299 RLKNTKET 306
>sp|O42872|RRP41_SCHPO Exosome complex component ski6 OS=Schizosaccharomyces
pombe GN=ski6 PE=2 SV=1
Length = 242
Score = 57 bits (135), Expect = 3e-007
Identities = 34/104 (32%), Positives = 53/104 (50%), Gaps = 5/104 (4%)
Frame = +1
Query: 313 MILKKTIQSICVLTVNPNTTTSVIIQVVHDDGSLLPCAINAACAALVDAGIPMKHLAVAI 492
+ L+ T + I + P + SV + V+ DDG+++ INA AL+DAGIP+K +
Sbjct: 100 LALQNTFEEIIQTELYPRSQISVYLHVLQDDGAVMASCINATTLALIDAGIPVKDF---V 156
Query: 493 CCCLAD--SGYVVLDPNKLEEKKMTAFAYLVFPNTTLSVLPEVE 618
CC A ++LD N LEE ++ V N V ++E
Sbjct: 157 CCSTAGIVESDMLLDLNSLEESALSWLTVAVLGNIKKVVYMQLE 200
>sp|Q8ZVM9|ECX1_PYRAE Probable exosome complex exonuclease 1 OS=Pyrobaculum
aerophilum GN=PAE2207 PE=3 SV=1
Length = 246
Score = 55 bits (131), Expect = 9e-007
Identities = 34/93 (36%), Positives = 50/93 (53%), Gaps = 1/93 (1%)
Frame = +1
Query: 274 KSGQIGKAEKEYEMILKKTIQSICVLTVNPNTTTSVIIQVVHDDGSLLPCAINAACAALV 453
KS + E E IL++ ++ VL P + V ++++ DGS ++ AA AL
Sbjct: 88 KSPTPSRREIEISKILREALEPAIVLEQYPRSRIDVFVEILQADGSTRVASLTAASLALA 147
Query: 454 DAGIPMKHLAVAICCCLADSGYVVLDPNKLEEK 552
DAGI M+ L V + L D G VVLD N LE++
Sbjct: 148 DAGIYMRDLVVGVSVGLVD-GTVVLDLNGLEDQ 179
>sp|A4WM67|ECX1_PYRAR Probable exosome complex exonuclease 1 OS=Pyrobaculum
arsenaticum (strain DSM 13514 / JCM 11321) GN=Pars_1937 PE=3 SV=1
Length = 246
Score = 55 bits (130), Expect = 1e-006
Identities = 33/92 (35%), Positives = 49/92 (53%), Gaps = 1/92 (1%)
Frame = +1
Query: 274 KSGQIGKAEKEYEMILKKTIQSICVLTVNPNTTTSVIIQVVHDDGSLLPCAINAACAALV 453
KS + E E +L++ ++ +L P + V I+++ DGS ++ AA AL
Sbjct: 88 KSPTPSRREIEISKVLREALEPAVLLEQYPRSRIDVFIEIIQADGSTRVASLTAASLALA 147
Query: 454 DAGIPMKHLAVAICCCLADSGYVVLDPNKLEE 549
DAGI M+ L V + L D G VVLD N LE+
Sbjct: 148 DAGIYMRDLVVGVSVGLVD-GVVVLDLNGLED 178
>sp|Q17533|EXOS4_CAEEL Putative exosome complex exonuclease RRP41
OS=Caenorhabditis elegans GN=exos-4.1 PE=2 SV=2
Length = 240
Score = 54 bits (129), Expect = 2e-006
Identities = 29/82 (35%), Positives = 43/82 (52%), Gaps = 1/82 (1%)
Frame = +1
Query: 304 EYEMILKKTIQSICVLTVNPNTTTSVIIQVVHDDGSLLPCAINAACAALVDAGIPMKHLA 483
E +L+K +S+ + P + + +V+ DGS L +NA AL DAGIPMK +A
Sbjct: 93 EISRLLEKAFESVILTEAFPRSQLDIFCEVIQGDGSNLAACVNATSLALADAGIPMKGIA 152
Query: 484 VAICCCLADSGYVVLDPNKLEE 549
A C + D G ++D EE
Sbjct: 153 SAATCGVVD-GKPIVDLTSREE 173
>sp|A3MUP1|ECX1_PYRCJ Probable exosome complex exonuclease 1 OS=Pyrobaculum
calidifontis (strain JCM 11548 / VA1) GN=Pcal_0933 PE=3 SV=1
Length = 246
Score = 54 bits (127), Expect = 3e-006
Identities = 33/92 (35%), Positives = 49/92 (53%), Gaps = 1/92 (1%)
Frame = +1
Query: 274 KSGQIGKAEKEYEMILKKTIQSICVLTVNPNTTTSVIIQVVHDDGSLLPCAINAACAALV 453
KS + E E +L++ ++ +L P + V I+++ DGS ++ AA AL
Sbjct: 88 KSPTPSRREIEISKVLREALEPAVMLEQYPRSRIDVFIEILQADGSTRVASLTAASLALA 147
Query: 454 DAGIPMKHLAVAICCCLADSGYVVLDPNKLEE 549
DAGI M+ L V + L D G VVLD N LE+
Sbjct: 148 DAGIYMRDLVVGVSVGLVD-GTVVLDLNGLED 178
>sp|B1Y978|ECX1_THENV Probable exosome complex exonuclease 1 OS=Thermoproteus
neutrophilus (strain DSM 2338 / JCM 9278 / V24Sta) GN=Tneu_1381 PE=3
SV=1
Length = 246
Score = 54 bits (127), Expect = 3e-006
Identities = 32/93 (34%), Positives = 50/93 (53%), Gaps = 1/93 (1%)
Frame = +1
Query: 274 KSGQIGKAEKEYEMILKKTIQSICVLTVNPNTTTSVIIQVVHDDGSLLPCAINAACAALV 453
KS + E E +L++ ++ +L P + V I+++ DGS ++ AA AL
Sbjct: 88 KSPTPSRREIEISKVLREALEPAVMLEQYPRSRIDVFIEILQADGSTRVASLTAASLALA 147
Query: 454 DAGIPMKHLAVAICCCLADSGYVVLDPNKLEEK 552
DAGI M+ L + + L D G VVLD N LE++
Sbjct: 148 DAGIYMRDLVIGVSVGLVD-GTVVLDLNGLEDQ 179
>sp|O59223|ECX1_PYRHO Probable exosome complex exonuclease 1 OS=Pyrococcus
horikoshii GN=PH1549 PE=3 SV=1
Length = 249
Score = 53 bits (126), Expect = 3e-006
Identities = 31/82 (37%), Positives = 43/82 (52%), Gaps = 1/82 (1%)
Frame = +1
Query: 304 EYEMILKKTIQSICVLTVNPNTTTSVIIQVVHDDGSLLPCAINAACAALVDAGIPMKHLA 483
E ++K ++ +L + P T+ V I+V+ D I AA AL DAGIPM+ L
Sbjct: 100 EISKVIKGALEPALILEMFPRTSIDVFIEVLQADAGTRVAGITAASLALADAGIPMRDL- 158
Query: 484 VAICCCLADSGYVVLDPNKLEE 549
VA C G +VLD NK E+
Sbjct: 159 VAACAAGKIEGEIVLDLNKEED 180
>sp|O29757|ECX1_ARCFU Probable exosome complex exonuclease 1 OS=Archaeoglobus
fulgidus GN=AF_0493 PE=1 SV=1
Length = 258
Score = 53 bits (125), Expect = 4e-006
Identities = 30/95 (31%), Positives = 51/95 (53%), Gaps = 4/95 (4%)
Frame = +1
Query: 304 EYEMILKKTIQSICVLTVNPNTTTSVIIQVVHDDGSLLPCAINAACAALVDAGIPMKHLA 483
E + K+ +++ + + P + + ++V+ D +NAA ALVDAG+PMK +
Sbjct: 100 EISKVSKEAFEAVIMKELFPRSAIDIFVEVLQADAGSRTACLNAASVALVDAGVPMKGMI 159
Query: 484 VAICCCLADSGYVVLDPNKLEEKKMTA---FAYLV 579
++ AD G +VLDP K E+ A FA+L+
Sbjct: 160 TSVAVGKAD-GQLVLDPMKEEDNFGEADMPFAFLI 193
>sp|A9A5C9|ECX1_NITMS Probable exosome complex exonuclease 1 OS=Nitrosopumilus
maritimus (strain SCM1) GN=Nmar_0432 PE=3 SV=1
Length = 244
Score = 52 bits (123), Expect = 7e-006
Identities = 36/112 (32%), Positives = 58/112 (51%), Gaps = 4/112 (3%)
Frame = +1
Query: 292 KAEKEYEMILKKTIQSICVLTVNPNTTTSVIIQVVHDDGSLLPCAINAACAALVDAGIPM 471
+ E E ++K+ ++ +L P T V I+V+ DG A+ AA AL DAGIPM
Sbjct: 96 RREIEISKVIKEALEPAVMLEKFPRTAVDVFIEVLQADGGTRCAALTAASVALADAGIPM 155
Query: 472 KHLAVAICC-CLADSGYVVLDPNKLEEKKMTAFAYLVF-PNTTLSVLPEVEG 621
+ + AI +AD+ V+LD N E++ A + + PN L +++G
Sbjct: 156 RDMVAAIAAGKVADT--VILDVNNEEDQAGQADMPIGYMPNLEKITLLQLDG 205
>sp|A8WQQ5|EXOS4_CAEBR Putative exosome complex exonuclease RRP41
OS=Caenorhabditis briggsae GN=exos-4.1 PE=3 SV=1
Length = 240
Score = 52 bits (122), Expect = 1e-005
Identities = 25/74 (33%), Positives = 40/74 (54%)
Frame = +1
Query: 304 EYEMILKKTIQSICVLTVNPNTTTSVIIQVVHDDGSLLPCAINAACAALVDAGIPMKHLA 483
E +L+K +S+ + P + + +V+ DGS L +NA AL DAGIPMK +A
Sbjct: 93 EISRLLEKAFESVILTESFPRSQIDIFCEVIQGDGSNLAACVNATSLALADAGIPMKGIA 152
Query: 484 VAICCCLADSGYVV 525
A C + ++ +V
Sbjct: 153 SAATCGIVETKPIV 166
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,590,037,747
Number of Sequences: 518415
Number of Extensions: 9590037747
Number of Successful Extensions: 72030089
Number of sequences better than 0.0: 0
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