BLASTX 7.6.2
Query= UN02609 /QuerySize=896
(895 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5R9T5|SPTC1_PONAB Serine palmitoyltransferase 1 OS=Pongo abe... 132 5e-030
sp|O15269|SPTC1_HUMAN Serine palmitoyltransferase 1 OS=Homo sapi... 129 3e-029
sp|Q60HD1|SPTC1_MACFA Serine palmitoyltransferase 1 OS=Macaca fa... 127 2e-028
sp|O35704|SPTC1_MOUSE Serine palmitoyltransferase 1 OS=Mus muscu... 126 2e-028
sp|O54695|SPTC1_CRIGR Serine palmitoyltransferase 1 OS=Cricetulu... 126 4e-028
sp|Q3MHG1|SPTC1_BOVIN Serine palmitoyltransferase 1 OS=Bos tauru... 117 1e-025
sp|Q55FL5|SPTC1_DICDI Serine palmitoyltransferase 1 OS=Dictyoste... 103 2e-021
sp|O59682|LCB1_SCHPO Serine palmitoyltransferase 1 OS=Schizosacc... 89 3e-017
sp|A7Z4X1|BIKB_BACA2 Putative 8-amino-7-oxononanoate synthase/2-... 56 3e-007
sp|P43090|HEM0_OPSTA 5-aminolevulinate synthase, erythroid-speci... 55 8e-007
sp|B5YFU5|BIKB_THEYD Putative 8-amino-7-oxononanoate synthase/2-... 53 2e-006
sp|Q1RIV2|HEM1_RICBR 5-aminolevulinate synthase OS=Rickettsia be... 53 3e-006
sp|Q92G23|HEM1_RICCN 5-aminolevulinate synthase OS=Rickettsia co... 53 3e-006
sp|Q4UJV4|HEM1_RICFE 5-aminolevulinate synthase OS=Rickettsia fe... 53 3e-006
sp|Q9ZCB8|HEM1_RICPR 5-aminolevulinate synthase OS=Rickettsia pr... 52 4e-006
sp|Q9YHT4|HEM0_DANRE 5-aminolevulinate synthase, erythroid-speci... 52 5e-006
>sp|Q5R9T5|SPTC1_PONAB Serine palmitoyltransferase 1 OS=Pongo abelii GN=SPTLC1
PE=2 SV=1
Length = 473
Score = 132 bits (330), Expect = 5e-030
Identities = 64/176 (36%), Positives = 113/176 (64%)
Frame = -1
Query: 835 EKIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVID 656
+ ID+++A M +ALA+ GGFC G + +ID+QRLS GY FSASLPP LA+AAI A+++++
Sbjct: 298 DDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIME 357
Query: 655 QNPELLVKMKQNIALLWKGLKDIKGMSLASDPESPIVFLKLEKSSGSTKDDLILLEKMAD 476
+NP + +K+ + K L+ I G+ + +P SP L+LE+S+GS + D+ LL+++ D
Sbjct: 358 ENPGIFAVLKEKCRQIHKALQGISGLKVVGEPLSPAFHLQLEESTGSREQDVRLLQEIVD 417
Query: 475 RALKEDSLLVVSSKKSFLDKCRLPVGIKLLVSAGHSDSDLIKVSESLKRLASELLL 308
+ + L + +KC P I+++V+ ++ +L + + ++K +A +LL
Sbjct: 418 QCMNRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELDRAASTIKEVAQAVLL 473
>sp|O15269|SPTC1_HUMAN Serine palmitoyltransferase 1 OS=Homo sapiens GN=SPTLC1
PE=1 SV=1
Length = 473
Score = 129 bits (323), Expect = 3e-029
Identities = 63/176 (35%), Positives = 112/176 (63%)
Frame = -1
Query: 835 EKIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVID 656
+ ID+++A M +ALA+ GGFC G + +ID+QRLS GY FSASLPP LA+AAI A+++++
Sbjct: 298 DDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIME 357
Query: 655 QNPELLVKMKQNIALLWKGLKDIKGMSLASDPESPIVFLKLEKSSGSTKDDLILLEKMAD 476
+NP + +K+ + K L+ I G+ + + SP L+LE+S+GS + D+ LL+++ D
Sbjct: 358 ENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVD 417
Query: 475 RALKEDSLLVVSSKKSFLDKCRLPVGIKLLVSAGHSDSDLIKVSESLKRLASELLL 308
+ + L + +KC P I+++V+ ++ +L + + ++K +A +LL
Sbjct: 418 QCMNRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVLL 473
>sp|Q60HD1|SPTC1_MACFA Serine palmitoyltransferase 1 OS=Macaca fascicularis
GN=SPTLC1 PE=2 SV=1
Length = 473
Score = 127 bits (317), Expect = 2e-028
Identities = 63/176 (35%), Positives = 111/176 (63%)
Frame = -1
Query: 835 EKIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVID 656
+ ID+++A M +ALA+ GGFC G + +ID+QRLS GY FSASLPP LA+AAI A+++++
Sbjct: 298 DDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIME 357
Query: 655 QNPELLVKMKQNIALLWKGLKDIKGMSLASDPESPIVFLKLEKSSGSTKDDLILLEKMAD 476
+NP + +K+ + K L+ I G+ + + SP L+LE+S+GS + D+ LL+++ D
Sbjct: 358 ENPGIFAVLKEKCRQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVD 417
Query: 475 RALKEDSLLVVSSKKSFLDKCRLPVGIKLLVSAGHSDSDLIKVSESLKRLASELLL 308
+ + L + +KC P I+++V+ + +L + + ++K +A +LL
Sbjct: 418 QCMDRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTAEELERAASTIKEVAQAVLL 473
>sp|O35704|SPTC1_MOUSE Serine palmitoyltransferase 1 OS=Mus musculus GN=Sptlc1
PE=2 SV=1
Length = 473
Score = 126 bits (316), Expect = 2e-028
Identities = 60/176 (34%), Positives = 113/176 (64%)
Frame = -1
Query: 835 EKIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVID 656
+ ID+++A M +ALA+ GGFC G + ++D+QRLS GY FSASLPP LA+AAI A+++++
Sbjct: 298 DDIDLISANMENALASVGGFCCGRSFVVDHQRLSGQGYCFSASLPPLLAAAAIEALNIME 357
Query: 655 QNPELLVKMKQNIALLWKGLKDIKGMSLASDPESPIVFLKLEKSSGSTKDDLILLEKMAD 476
+NP++ +K+ + K L+ + G+ + + SP + L+LE+S+GS + D+ LL+ + D
Sbjct: 358 ENPDIFAVLKKKCQNIHKSLQGVSGLKVVGESLSPALHLQLEESTGSREKDVKLLQAIVD 417
Query: 475 RALKEDSLLVVSSKKSFLDKCRLPVGIKLLVSAGHSDSDLIKVSESLKRLASELLL 308
+ + + L + +KC P I+++V+ ++ +L + + +++ A +LL
Sbjct: 418 QCMDKGIALTQARYLDKEEKCLPPPSIRVVVTVEQTEEELQRAASTIREAAQAVLL 473
>sp|O54695|SPTC1_CRIGR Serine palmitoyltransferase 1 OS=Cricetulus griseus
GN=SPTLC1 PE=2 SV=1
Length = 473
Score = 126 bits (314), Expect = 4e-028
Identities = 62/176 (35%), Positives = 111/176 (63%)
Frame = -1
Query: 835 EKIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVID 656
+ ID+++A M +ALA+ GGFC G + ++D+QRLS GY FSASLPP LA+AAI A+++++
Sbjct: 298 DDIDLISANMENALASVGGFCCGRSFVVDHQRLSGQGYCFSASLPPLLAAAAIEALNIME 357
Query: 655 QNPELLVKMKQNIALLWKGLKDIKGMSLASDPESPIVFLKLEKSSGSTKDDLILLEKMAD 476
+NP + +K+ + K L+ I G+ + + SP + L+LE+S+GS + D+ LL++M
Sbjct: 358 ENPGIFAVLKKKCQHIHKSLQGISGLKVVGESLSPALHLQLEESTGSREKDVQLLQEMVI 417
Query: 475 RALKEDSLLVVSSKKSFLDKCRLPVGIKLLVSAGHSDSDLIKVSESLKRLASELLL 308
+ E L + +KC P I+++V+ ++ +L + + +++ A +LL
Sbjct: 418 HCMNEGIALTQARYLDKEEKCLPPPSIRVVVTVEQTEEELERAASTIREAAQAVLL 473
>sp|Q3MHG1|SPTC1_BOVIN Serine palmitoyltransferase 1 OS=Bos taurus GN=SPTLC1
PE=2 SV=1
Length = 473
Score = 117 bits (292), Expect = 1e-025
Identities = 59/176 (33%), Positives = 109/176 (61%)
Frame = -1
Query: 835 EKIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVID 656
+ ID+++A M ++LA+ GGFC G + +ID+QRLS GY FSASLPP LA+AAI A+++++
Sbjct: 298 DDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIME 357
Query: 655 QNPELLVKMKQNIALLWKGLKDIKGMSLASDPESPIVFLKLEKSSGSTKDDLILLEKMAD 476
+NP + +K+ + K L+ I G+ + + SP + L+LE+++G + D+ LL+++
Sbjct: 358 ENPGIFAVLKEKCKRIHKALQGIPGLKVVGESISPALHLQLEETTGCRERDVKLLQEIVT 417
Query: 475 RALKEDSLLVVSSKKSFLDKCRLPVGIKLLVSAGHSDSDLIKVSESLKRLASELLL 308
+ + L + +K P I+++V+ ++ DL K + ++ +A +LL
Sbjct: 418 QCMDRGIALTQARYLEKEEKYLPPPSIRVVVTVEQTEEDLEKAASTISEVAQTVLL 473
>sp|Q55FL5|SPTC1_DICDI Serine palmitoyltransferase 1 OS=Dictyostelium discoideum
GN=sptA PE=3 SV=1
Length = 479
Score = 103 bits (255), Expect = 2e-021
Identities = 61/180 (33%), Positives = 112/180 (62%), Gaps = 8/180 (4%)
Frame = -1
Query: 829 IDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVIDQN 650
+D++T + G++ ++ GGFC G+ ++ +QRL+ GYVFSASLPP+LA ++ AI+++++N
Sbjct: 298 VDILTGSYGNSFSSGGGFCCGSPEVVYHQRLNGVGYVFSASLPPFLACSSTKAIEMLEEN 357
Query: 649 PELLVKMKQNIALLWKGLKD---IKG-MSLASDPESPIVFLKL--EKSSGSTK-DDLILL 491
P++L + NI L++GL + G + + S P SP++ L L KS+ S + +D +LL
Sbjct: 358 PKMLEMLHSNIGELYQGLNKSGALNGLLEITSLPISPVIHLSLLDSKSNKSNRINDELLL 417
Query: 490 EKMADRALKEDSLLVVSSKKSFLDKCRLPVGIKLLVSAGHSDSDLIKVSESLKRLASELL 311
+K+ D+A+ + LL+ +K +K I++ VS+ S + + E +K+ S +L
Sbjct: 418 QKIVDKAM-DYGLLLTRAKYVSAEKFIPKPSIRISVSSNLSSDQIKQSIEIIKKCTSFVL 476
>sp|O59682|LCB1_SCHPO Serine palmitoyltransferase 1 OS=Schizosaccharomyces pombe
GN=lcb1 PE=2 SV=1
Length = 509
Score = 89 bits (220), Expect = 3e-017
Identities = 48/171 (28%), Positives = 95/171 (55%), Gaps = 1/171 (0%)
Frame = -1
Query: 841 PYEKIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDV 662
P ++++ ++ +LA GGFC G+ ++++QRLS Y++SA+LP LA AA AI +
Sbjct: 323 PPTDVEIIIGSLTTSLAGGGGFCAGSELMVEHQRLSGMAYIYSAALPASLAVAAYEAISI 382
Query: 661 IDQN-PELLVKMKQNIALLWKGLKDIKGMSLASDPESPIVFLKLEKSSGSTKDDLILLEK 485
+ ++ +L ++ AL L K +SD ESPI+ L+ + S + LLE+
Sbjct: 383 LSRDGGSMLNDLRSKSALFHAKLSRNKFFETSSDIESPIIHLRFKDKDISHDKQVFLLEE 442
Query: 484 MADRALKEDSLLVVSSKKSFLDKCRLPVGIKLLVSAGHSDSDLIKVSESLK 332
+ + + E L+ + + L++ ++ +++ +S GHS ++ K++ +K
Sbjct: 443 IVELCIAEGFLIARAKRVESLERVKVQPSLRICISTGHSAEEIEKLALLIK 493
>sp|A7Z4X1|BIKB_BACA2 Putative 8-amino-7-oxononanoate
synthase/2-amino-3-ketobutyrate coenzyme A ligase OS=Bacillus
amyloliquefaciens (strain FZB42) GN=RBAM_016840 PE=3 SV=1
Length = 391
Score = 56 bits (133), Expect = 3e-007
Identities = 35/114 (30%), Positives = 60/114 (52%), Gaps = 3/114 (2%)
Frame = -1
Query: 832 KIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVIDQ 653
++ + + A+ GG+ G+ +IDY R ++FS S PP + +A I AIDV+ +
Sbjct: 229 RVHIQVGTLSKAIGVLGGYAAGSQVLIDYLRHKGRPFLFSTSHPPAVTAACIEAIDVLLE 288
Query: 652 NPELLVKMKQNIALLWKGLKDIKGMSLASDPESPIVFLKL-EKSSGSTKDDLIL 494
PE + K+ +N A L + G++L E+PIV + + E+ DL+L
Sbjct: 289 EPEHMEKLWENTAYFKDKLVQM-GLTLTKS-ETPIVPILIGEEEKAQALSDLLL 340
>sp|P43090|HEM0_OPSTA 5-aminolevulinate synthase, erythroid-specific,
mitochondrial OS=Opsanus tau GN=alas2 PE=2 SV=1
Length = 582
Score = 55 bits (130), Expect = 8e-007
Identities = 36/118 (30%), Positives = 67/118 (56%), Gaps = 4/118 (3%)
Frame = -1
Query: 832 KIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVIDQ 653
KID+V+ +G A GG+ +A ++D R ++G++F+ SLPP + + A+ ++ V+ +
Sbjct: 376 KIDIVSGTLGKAFGCVGGYVASSAALVDTVRSFAAGFIFTTSLPPMILAGALESVRVL-K 434
Query: 652 NPE--LLVKMKQNIALLWKGLKDIKGMSLASDPESPIVFLKLEKSSGSTKDDLILLEK 485
+PE LL + Q + L KG+ + + P S I+ +++ + +TK LLEK
Sbjct: 435 SPEGQLLRRAHQRNVKYMRQLLMDKGLPVVNCP-SHIIPIRVGNAELNTKVCDSLLEK 491
>sp|B5YFU5|BIKB_THEYD Putative 8-amino-7-oxononanoate
synthase/2-amino-3-ketobutyrate coenzyme A ligase
OS=Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 /
YP87) GN=THEYE_A1333 PE=3 SV=1
Length = 388
Score = 53 bits (126), Expect = 2e-006
Identities = 29/105 (27%), Positives = 59/105 (56%), Gaps = 1/105 (0%)
Frame = -1
Query: 835 EKIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVID 656
E + + A+ G F G++ IID+ S+ G++FS SLPP ++A ++ +I
Sbjct: 230 EAFVIQMGTLSKAIGVFGAFVCGDSSIIDWFINSARGFIFSTSLPPSTVASAYASLKIIM 289
Query: 655 QNPELLVKMKQNIALLWKGLKDIK-GMSLASDPESPIVFLKLEKS 524
++ EL+ ++ QNI + + +K+++ + P PI+F +E++
Sbjct: 290 EDKELIKRLWQNIEKVMEIIKNLELKTTKTQTPIIPILFENIEQA 334
>sp|Q1RIV2|HEM1_RICBR 5-aminolevulinate synthase OS=Rickettsia bellii (strain
RML369-C) GN=hemA PE=3 SV=1
Length = 414
Score = 53 bits (125), Expect = 3e-006
Identities = 23/56 (41%), Positives = 38/56 (67%)
Frame = -1
Query: 835 EKIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAI 668
++ID++ + A T GG+ T N +ID RLS+SG++F+ SLPP +++AA +I
Sbjct: 233 DEIDIIQGTLAKAYGTIGGYITANHSLIDAIRLSASGFIFTTSLPPVISTAATHSI 288
>sp|Q92G23|HEM1_RICCN 5-aminolevulinate synthase OS=Rickettsia conorii GN=hemA
PE=3 SV=2
Length = 414
Score = 53 bits (125), Expect = 3e-006
Identities = 23/76 (30%), Positives = 47/76 (61%)
Frame = -1
Query: 835 EKIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVID 656
++ID++ + A T GG+ T N ++D RL++ G++F+ SLPP +++AA +I +
Sbjct: 233 DQIDIIQGTLAKAYGTIGGYITSNHNLVDAIRLTAPGFIFTTSLPPVISTAATHSIRHLK 292
Query: 655 QNPELLVKMKQNIALL 608
++ E +K ++ + L
Sbjct: 293 ESNEERIKHQEVVTKL 308
>sp|Q4UJV4|HEM1_RICFE 5-aminolevulinate synthase OS=Rickettsia felis GN=hemA
PE=3 SV=1
Length = 414
Score = 53 bits (125), Expect = 3e-006
Identities = 23/76 (30%), Positives = 47/76 (61%)
Frame = -1
Query: 835 EKIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVID 656
++ID++ + A T GG+ T N ++D RL++ G++F+ SLPP +++AA +I +
Sbjct: 233 DQIDIIQGTLAKAYGTIGGYITSNHNLVDAIRLTAPGFIFTTSLPPVISTAATHSIRHLK 292
Query: 655 QNPELLVKMKQNIALL 608
++ E +K ++ + L
Sbjct: 293 ESNEERIKHQEVVTKL 308
>sp|Q9ZCB8|HEM1_RICPR 5-aminolevulinate synthase OS=Rickettsia prowazekii
GN=hemA PE=3 SV=1
Length = 414
Score = 52 bits (124), Expect = 4e-006
Identities = 24/75 (32%), Positives = 46/75 (61%)
Frame = -1
Query: 832 KIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVIDQ 653
+ID++ + A T GG+ T N +ID RL++ G++F+ SLPP +++AA +I + +
Sbjct: 234 QIDIIQGTLAKAYGTIGGYITSNYNLIDAIRLTAPGFIFTTSLPPVISTAATHSIRHLKE 293
Query: 652 NPELLVKMKQNIALL 608
+ E +K ++ + L
Sbjct: 294 SNEERIKHQEVVTKL 308
>sp|Q9YHT4|HEM0_DANRE 5-aminolevulinate synthase, erythroid-specific,
mitochondrial OS=Danio rerio GN=alas2 PE=2 SV=1
Length = 583
Score = 52 bits (123), Expect = 5e-006
Identities = 33/118 (27%), Positives = 68/118 (57%), Gaps = 4/118 (3%)
Frame = -1
Query: 832 KIDVVTAAMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVI-- 659
KID+V+ +G A GG+ A ++D R ++G++F+ SLPP + + A+ ++ V+
Sbjct: 376 KIDIVSGTLGKAFGCVGGYIASTAALVDTVRSFAAGFIFTTSLPPMVLAGALESVRVLKS 435
Query: 658 DQNPELLVKMKQNIALLWKGLKDIKGMSLASDPESPIVFLKLEKSSGSTKDDLILLEK 485
D+ L ++N+ + + L D G+ + + P S I+ +++ ++ +++ ILLEK
Sbjct: 436 DEGQALRRAHQRNVKHMRQLLLD-AGLPVVNCP-SHIIPIRVGNAAKNSEVCDILLEK 491
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,533,745,664
Number of Sequences: 518415
Number of Extensions: 12533745664
Number of Successful Extensions: 80211091
Number of sequences better than 0.0: 0
|
