BLASTX 7.6.2
Query= UN02637 /QuerySize=1160
(1159 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo... 148 1e-034
sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pong... 147 2e-034
sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus ... 145 8e-034
sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Dani... 141 1e-032
sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gall... 139 5e-032
sp|Q9QYF1|RDH11_MOUSE Retinol dehydrogenase 11 OS=Mus musculus G... 134 1e-030
sp|Q8VBZ0|DHRSX_MOUSE Dehydrogenase/reductase SDR family member ... 133 3e-030
sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12 OS=Mus musculus G... 133 3e-030
sp|Q9VLU5|WWOX_DROME WW domain-containing oxidoreductase OS=Dros... 132 7e-030
sp|Q8TC12|RDH11_HUMAN Retinol dehydrogenase 11 OS=Homo sapiens G... 131 2e-029
sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member ... 129 5e-029
sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 OS=Bos taurus GN=... 126 3e-028
sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 OS=Homo sapiens G... 125 7e-028
sp|O74959|YJCD_SCHPO Uncharacterized oxidoreductase C736.13 OS=S... 123 3e-027
sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13 OS=Homo sapiens G... 103 4e-021
sp|Q8CEE7|RDH13_MOUSE Retinol dehydrogenase 13 OS=Mus musculus G... 97 2e-019
sp|Q01289|POR_PEA Protochlorophyllide reductase, chloroplastic O... 97 3e-019
sp|Q41249|PORA_CUCSA Protochlorophyllide reductase, chloroplasti... 93 3e-018
sp|Q7XKF3|PORA_ORYSJ Protochlorophyllide reductase A, chloroplas... 91 2e-017
sp|Q03326|OXIR_STRAT Probable oxidoreductase OS=Streptomyces ant... 80 2e-014
>sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo sapiens
GN=WWOX PE=1 SV=1
Length = 414
Score = 148 bits (372), Expect = 1e-034
Identities = 101/281 (35%), Positives = 151/281 (53%), Gaps = 20/281 (7%)
Frame = -2
Query: 1032 FSARSTAEEVTHGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKE 853
+ +TA E+ G D TG +VTGA+SGIG ETA+ AL G HV++A RN ++
Sbjct: 107 YDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVS 166
Query: 852 DIVNGIPGAKLDVMELDLSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIE 673
I+ AK++ M LDL+ + SV+ FA +K+ +PL++L+ NA A P+ L+KD +E
Sbjct: 167 RILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLE 226
Query: 672 LQFATNHLGHLLLTKFLLDTMKNT--------SRESKREAGL*IYHQKLIGSRIHKSPL* 517
F NHLGH L + L D + + S ES R + KL SR+ SP
Sbjct: 227 TTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRL--SPTK 284
Query: 516 *DQRQVKLQ*YASLWTV*LCNVLHANELAKQLKEDGVNITANSLHPGAIM-TNFGRYFNS 340
D + + LCN+L +NEL ++L GV T+N++HPG +M +N R +
Sbjct: 285 NDYWAMLAYNRSK-----LCNILFSNELHRRLSPRGV--TSNAVHPGNMMYSNIHRSWWV 337
Query: 339 YLAGAVGAVAKYVLKTVPQGGGTTCYVALNPQVTGVTGEYF 217
Y + +A+ K++ QG TT Y A P++ G+ G YF
Sbjct: 338 YT--LLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYF 376
>sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pongo abelii
GN=WWOX PE=2 SV=1
Length = 414
Score = 147 bits (369), Expect = 2e-034
Identities = 101/281 (35%), Positives = 151/281 (53%), Gaps = 20/281 (7%)
Frame = -2
Query: 1032 FSARSTAEEVTHGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKE 853
+ +TA E+ G D TG +VTGA+SGIG ETA+ AL G HV++A RN ++
Sbjct: 107 YDGSTTALEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVS 166
Query: 852 DIVNGIPGAKLDVMELDLSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIE 673
I+ AK++ + LDL+ + SV+ FA +K+ +PL++L+ NA A P+ L+KD +E
Sbjct: 167 RILEEWHKAKVEAVTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLE 226
Query: 672 LQFATNHLGHLLLTKFLLDTMKNT--------SRESKREAGL*IYHQKLIGSRIHKSPL* 517
F NHLGH L + L D + + S ES R + KL SR+ SP
Sbjct: 227 TTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRL--SPTK 284
Query: 516 *DQRQVKLQ*YASLWTV*LCNVLHANELAKQLKEDGVNITANSLHPGAIM-TNFGRYFNS 340
D + + LCNVL +NEL ++L GV T+N++HPG +M +N R +
Sbjct: 285 NDYWAMLAYNRSK-----LCNVLFSNELHRRLSPRGV--TSNAVHPGNMMYSNIHRSWWV 337
Query: 339 YLAGAVGAVAKYVLKTVPQGGGTTCYVALNPQVTGVTGEYF 217
Y + +A+ K++ QG TT Y A P++ G+ G YF
Sbjct: 338 YT--LLFTLARPFTKSMQQGAATTVYCAAAPELEGLGGMYF 376
>sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus musculus
GN=Wwox PE=1 SV=1
Length = 414
Score = 145 bits (364), Expect = 8e-034
Identities = 94/275 (34%), Positives = 147/275 (53%), Gaps = 8/275 (2%)
Frame = -2
Query: 1032 FSARSTAEEVTHGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKE 853
+ +TA E+ G D TG +VTGA+SGIG ETA+ AL G HV++A RN ++
Sbjct: 107 YDGSTTAMEILQGRDFTGKVVLVTGANSGIGFETAKSFALHGAHVILACRNLSRASEAVS 166
Query: 852 DIVNGIPGAKLDVMELDLSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIE 673
I+ AK++ M LDL+ + SV+ FA +K+ + L++L+ NAG A P+ L+KD +E
Sbjct: 167 RILEEWHKAKVEAMTLDLAVLRSVQHFAEAFKAKNVSLHVLVCNAGTFALPWGLTKDGLE 226
Query: 672 LQFATNHLGHLLLTKFLLDTMKNTSRESKREAGL*IYHQKLIGSRIHKSPL**DQRQVKL 493
F NHLGH L + L D + +S + I K L +
Sbjct: 227 TTFQVNHLGHFYLVQLLQDVLCRSSPARVIVVSSESHRFTDINDSSGKLDL--SRLSPPR 284
Query: 492 Q*YASLWTV---*LCNVLHANELAKQLKEDGVNITANSLHPGAIMTNFGRYFNSYLAGAV 322
Y ++ LCN+L +NEL ++L GV T+N++HPG +M + + NS++ +
Sbjct: 285 SDYWAMLAYNRSKLCNILFSNELHRRLSPRGV--TSNAVHPGNMMYS-AIHRNSWVYKLL 341
Query: 321 GAVAKYVLKTVPQGGGTTCYVALNPQVTGVTGEYF 217
+A+ K++ QG TT Y A+ P++ G+ G YF
Sbjct: 342 FTLARPFTKSMQQGAATTVYCAVAPELEGLGGMYF 376
>sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Danio rerio GN=wwox
PE=2 SV=1
Length = 412
Score = 141 bits (354), Expect = 1e-032
Identities = 98/290 (33%), Positives = 157/290 (54%), Gaps = 10/290 (3%)
Frame = -2
Query: 1032 FSARSTAEEVTHGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKE 853
+ + A E+ HG D + IVTGA+SGIG ETAR AL G HV++A RN +K
Sbjct: 104 YDGNTGALEILHGQDLSDKVIIVTGANSGIGFETARSFALHGAHVILACRNQSRASKAAS 163
Query: 852 DIVNGIPGAKLDVMELDLSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIE 673
I+ A+++V+ LDL+S+ SVR+FA +K++ LPL++L+ NA + + P+ L++D E
Sbjct: 164 LIMGEWSKARVEVLPLDLASLRSVRQFAELFKATKLPLHVLVCNAAVCSQPWRLTEDGFE 223
Query: 672 LQFATNHLGHLLLTKFLLDTMKNTSRESKREAGL*IYHQKLIGSRIHKSPL**DQRQVKL 493
F HLGH LL + L D ++ ++ R + + L D
Sbjct: 224 STFQICHLGHFLLVQLLQDVLRLSA--PARVVVVSSESHRFTDLLDSCGNLDLDLLSPPQ 281
Query: 492 Q*YASLWT---V*LCNVLHANELAKQLKEDGVNITANSLHPGAIM-TNFGRYFNSYLAGA 325
+ Y SL LCN+L ++EL +++ G I N+LHPG++M T+ R + +L
Sbjct: 282 KNYWSLLAYNRAKLCNLLFSSELHRRMSPHG--ICCNALHPGSMMFTSIHRSW--WLLTL 337
Query: 324 VGAVAKYVLKTVPQGGGTTCYVALNPQVTGVTGEYFLDSNIAKPLSLAKD 175
+ ++A+ K++ QG TT Y A+ P++ G+ G YF + P A+D
Sbjct: 338 LFSLARPFTKSMQQGAATTVYCAVAPELEGIGGMYFNNCFRCLPSPQAQD 387
>sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gallus gallus
GN=WWOX PE=2 SV=2
Length = 414
Score = 139 bits (349), Expect = 5e-032
Identities = 91/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Frame = -2
Query: 1032 FSARSTAEEVTHGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKE 853
+ STA E+ G D +G I+TGA+SGIG ETA+ AL G +V++A RN G +
Sbjct: 107 YDGNSTAMEILQGRDLSGKVIIITGANSGIGFETAKSFALHGAYVILACRNMSRGNDAVQ 166
Query: 852 DIVNGIPGAKLDVMELDLSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIE 673
I+ AK++ M LDL+S+ SV+ FA +KS +PL++L+ NA I + L++D +E
Sbjct: 167 RILEEWHKAKVEAMTLDLASLRSVQNFAEAFKSKNMPLHILVCNAAIFGSSWCLTEDGLE 226
Query: 672 LQFATNHLGHLLLTKFLLDTMKNTSRESKREAGL*IYHQKLIGSRIHKSPL**DQRQVKL 493
F NHLGH L + L D ++ +S R + + + L
Sbjct: 227 STFQVNHLGHFYLVQLLEDILRRSS--PARVVVVSSESHRFTEIKDSSGKLDFSLLSPSK 284
Query: 492 Q*YASLWTV---*LCNVLHANELAKQLKEDGVNITANSLHPGAIMTNFGRYFNSYLAGAV 322
+ Y ++ LCN+L +NEL ++L GV T+NS+HPG ++ + + N ++ +
Sbjct: 285 KEYWAMLAYNRSKLCNILFSNELNRRLSPHGV--TSNSVHPGNMIYS-SIHRNWWVYTLL 341
Query: 321 GAVAKYVLKTVPQGGGTTCYVALNPQVTGVTGEYF 217
+A+ K++ QG TT Y A ++ G+ G YF
Sbjct: 342 FTLARPFTKSMQQGAATTVYCATAAELEGLGGMYF 376
>sp|Q9QYF1|RDH11_MOUSE Retinol dehydrogenase 11 OS=Mus musculus GN=Rdh11 PE=2
SV=2
Length = 316
Score = 134 bits (336), Expect = 1e-030
Identities = 93/268 (34%), Positives = 135/268 (50%), Gaps = 11/268 (4%)
Frame = -2
Query: 1002 THGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNGIPGAK 823
T V G AIVTGA++GIG ETA+ LA RG V +A R+ G +I ++
Sbjct: 31 TSNVQLPGKVAIVTGANTGIGKETAKDLAQRGARVYLACRDVDKGELAAREIQAVTGNSQ 90
Query: 822 LDVMELDLSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIELQFATNHLGH 643
+ V +LDL+ S+R FA D+ + L+LLINNAG+M CP+ + D E+ NHLGH
Sbjct: 91 VFVRKLDLADTKSIRAFAKDFLAEEKHLHLLINNAGVMMCPYSKTADGFEMHIGVNHLGH 150
Query: 642 LLLTKFLLDTMKNTSRESKREAGL*IYHQKLIGSRIHKSPL**DQRQVKLQ*YASLWTV* 463
LLT LL+ +K ++ +H RIH L Q + +
Sbjct: 151 FLLTHLLLEKLKESAPSRIVNLSSLGHHL----GRIHFHNL---QGEKFYSAGLAYCHSK 203
Query: 462 LCNVLHANELAKQLKEDGVNITANSLHPGAIMTNFGRYFNSYLAGAVGAVAKYVLKTVPQ 283
L N+L ELAK+LK GV T S+HPG + + RY S + + + +KT +
Sbjct: 204 LANILFTKELAKRLKGSGV--TTYSVHPGTVHSELTRY--SSIMRWLWQLFFVFIKTPQE 259
Query: 282 GGGTTCYVALNPQVTGVTGEYFLDSNIA 199
G T+ Y AL + ++G +F D +A
Sbjct: 260 GAQTSLYCALTEGLESLSGSHFSDCQLA 287
>sp|Q8VBZ0|DHRSX_MOUSE Dehydrogenase/reductase SDR family member on chromosome X
homolog OS=Mus musculus GN=Dhrsx PE=2 SV=2
Length = 335
Score = 133 bits (333), Expect = 3e-030
Identities = 94/283 (33%), Positives = 138/283 (48%), Gaps = 3/283 (1%)
Frame = -2
Query: 981 GLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNGIPGAKLDVMELD 802
G AIVTGA++GIG TAR LA G+ VV+A + G +V I + + + LD
Sbjct: 43 GRVAIVTGATAGIGRSTARQLARLGMCVVVAGNDEHRGQEVVSSIRAEMGSDRAHFLPLD 102
Query: 801 LSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHLLLTKFL 622
L+S+ SVR FA D+++ GLPL+LL+NNAG+M P ++D E N LGH LLT L
Sbjct: 103 LASLASVRGFARDFQALGLPLHLLVNNAGVMLEPRAETEDGFERHLGVNFLGHFLLTLLL 162
Query: 621 LDTMKNTSRESKREAGL*IYHQKLIGSRIHKSPL**DQRQVKLQ*YASLWTV*LCNVLHA 442
L ++ + E + + + + + L + YA+ L L A
Sbjct: 163 LPALRASGAEGRGSRVVTVGSATHYVGTVDMADL---HGRHAYSPYAAYAQSKLALALFA 219
Query: 441 NELAKQLKEDGVNITANSLHPGAIMTNFGRYFNSYLAGAVGAVAKYVLKTVPQGGGTTCY 262
+L + L G +T+N PG + T R+ L A + V K+ +G T Y
Sbjct: 220 LQLQRILDARGDPVTSNMADPGVVDTELYRHAGWVLRTAKRFLGWLVFKSPEEGAWTLVY 279
Query: 261 VALNPQVTGVTGEYFLDSNIAKPLSLAKDSDWPRRFGSSALSL 133
A P++ GV G Y D A+PL A+D + RR + L L
Sbjct: 280 AAAAPELEGVGGRYLRDEAEAEPLGTARDQELQRRLWAEGLRL 322
>sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12 OS=Mus musculus GN=Rdh12 PE=2
SV=1
Length = 316
Score = 133 bits (333), Expect = 3e-030
Identities = 90/264 (34%), Positives = 134/264 (50%), Gaps = 11/264 (4%)
Frame = -2
Query: 1002 THGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNGIPGAK 823
T V G ++TGA++GIG ETAR LA RG V +A R+ G +I ++
Sbjct: 32 TTNVQIPGKVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIRADTKNSQ 91
Query: 822 LDVMELDLSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIELQFATNHLGH 643
+ V +LDLS S+R FA + + L++LINNAG+M CP+ + D E F NHLGH
Sbjct: 92 VLVRKLDLSDTKSIRAFAERFLAEEKKLHILINNAGVMMCPYSKTTDGFETHFGVNHLGH 151
Query: 642 LLLTKFLLDTMKNTSRESKREAGL*IYHQKLIGSRIHKSPL**DQRQVKLQ*YASLWTV* 463
LLT LL+ +K + A + + I I K Q Q + +
Sbjct: 152 FLLTYLLLERLKES-------APARVVNLSSIAHLIGKIRFHDLQGQKRYCSAFAYGHSK 204
Query: 462 LCNVLHANELAKQLKEDGVNITANSLHPGAIMTNFGRYFNSYLAGAVGAVAKYVLKTVPQ 283
L N+L ELAK+L+ G +TA ++HPG +++ R NSYL + + K+ Q
Sbjct: 205 LANLLFTRELAKRLQ--GTGVTAYAVHPGVVLSEITR--NSYLLCLLWRLFSPFFKSTSQ 260
Query: 282 GGGTTCYVALNPQVTGVTGEYFLD 211
G T+ + AL + ++G+YF D
Sbjct: 261 GAQTSLHCALAEDLEPLSGKYFSD 284
>sp|Q9VLU5|WWOX_DROME WW domain-containing oxidoreductase OS=Drosophila
melanogaster GN=Wwox PE=2 SV=1
Length = 409
Score = 132 bits (330), Expect = 7e-030
Identities = 101/297 (34%), Positives = 154/297 (51%), Gaps = 24/297 (8%)
Frame = -2
Query: 1032 FSARSTAEEVTHGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKE 853
F + STA +V HG D G TA++TGA+ GIG ETAR LA G ++ A RN S E
Sbjct: 104 FDSCSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIE 163
Query: 852 DIVNGIPGA--KLDVMELDLSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDN 679
I P A + LDLSS+ SV++F + K S ++ LI NAG+ A P+ + D
Sbjct: 164 RIAQERPAARSRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDG 223
Query: 678 IELQFATNHLGHLLLTKFLLDTMKN-------TSRESKREAGL*IYHQKLIGSRIHKSPL 520
+E F +HL H LT L+T+ + S ES R A L + + + H SP
Sbjct: 224 LETTFQVSHLSHFYLT-LQLETLFDYKTRIIVLSSESHRFANLPVENLAV----HHLSPP 278
Query: 519 **DQRQVKLQ*YASLWTV*LCNVLHANELAKQLKEDGVNITANSLHPG-AIMTNFGRYFN 343
++ + Y + LCNVL A ELA++ K+ G+++ SLHPG + ++ R N
Sbjct: 279 --PEKYWSMMAYNN---AKLCNVLFAQELAQRWKQRGISVF--SLHPGNMVSSDLSR--N 329
Query: 342 SYLAGAVGAVAKYVLKTVPQGGGTTCYVALNPQVTGVTGEYFLDSNIAKPLSLAKDS 172
+ + A+ + K++ Q T+ Y A ++TG++G YF + +P L+K +
Sbjct: 330 YWFYRLLFAIVRPFTKSLQQAAATSIYCATANELTGLSGLYFNNCFFCEPSKLSKSA 386
>sp|Q8TC12|RDH11_HUMAN Retinol dehydrogenase 11 OS=Homo sapiens GN=RDH11 PE=1
SV=2
Length = 318
Score = 131 bits (327), Expect = 2e-029
Identities = 92/282 (32%), Positives = 141/282 (50%), Gaps = 11/282 (3%)
Frame = -2
Query: 1002 THGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNGIPGAK 823
T V G +VTGA++GIG ETA+ LA RG V +A R+ G V ++I +
Sbjct: 34 TSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQ 93
Query: 822 LDVMELDLSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIELQFATNHLGH 643
+ V +LDLS S+R FA + + L++LINNAG+M CP+ + D E+ NHLGH
Sbjct: 94 VLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGH 153
Query: 642 LLLTKFLLDTMKNTSRESKREAGL*IYHQKLIGSRIHKSPL**DQRQVKLQ*YASLWTV* 463
LLT LL+ +K ++ +H RIH L Q + +
Sbjct: 154 FLLTHLLLEKLKESAPSRIVNVSSLAHHL----GRIHFHNL---QGEKFYNAGLAYCHSK 206
Query: 462 LCNVLHANELAKQLKEDGVNITANSLHPGAIMTNFGRYFNSYLAGAVGAVAKYVLKTVPQ 283
L N+L ELA++LK GV T S+HPG + + R+ S + + + +KT Q
Sbjct: 207 LANILFTQELARRLKGSGV--TTYSVHPGTVQSELVRH--SSFMRWMWWLFSFFIKTPQQ 262
Query: 282 GGGTTCYVALNPQVTGVTGEYFLDSNIAKPLSLAKDSDWPRR 157
G T+ + AL + ++G +F D ++A + A++ RR
Sbjct: 263 GAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARR 304
>sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member on chromosome X
OS=Homo sapiens GN=DHRSX PE=2 SV=2
Length = 330
Score = 129 bits (323), Expect = 5e-029
Identities = 85/284 (29%), Positives = 140/284 (49%), Gaps = 11/284 (3%)
Frame = -2
Query: 972 AIVTGASSGIGVETARVLALRGVHVVMAVRNTGSG----AKVKEDIVNGIPGAKLDVMEL 805
AIVTG + GIG TA+ LA G+HV++A N +K+KE+ +N K++ +
Sbjct: 46 AIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLND----KVEFLYC 101
Query: 804 DLSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHLLLTKF 625
DL+SM S+R+F +K +PL++LINNAG+M P ++D E F N+LGH LLT
Sbjct: 102 DLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNL 161
Query: 624 LLDTMKNTSRESKREAGL*IYHQKLIGSRIHKSPL**DQRQVKLQ*YASLWTV*LCNVLH 445
LLDT+K + + + + ++ L Q +A+ L VL
Sbjct: 162 LLDTLKESGSPGHSARVVTVSSATHYVAELNMDDL---QSSACYSPHAAYAQSKLALVLF 218
Query: 444 ANELAKQLKEDGVNITANSLHPGAIMTNFGRYFNSYLAGAVGAVAKYVLKTVPQGGGTTC 265
L + L +G ++TAN + PG + T+ ++ A + + KT +G T+
Sbjct: 219 TYHLQRLLAAEGSHVTANVVDPGVVNTDVYKHVFWATRLAKKLLGWLLFKTPDEGAWTSI 278
Query: 264 YVALNPQVTGVTGEYFLDSNIAKPLSLAKDSDWPRRFGSSALSL 133
Y A+ P++ GV G Y + K L + + ++ S + +
Sbjct: 279 YAAVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEM 322
>sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 OS=Bos taurus GN=RDH12 PE=2
SV=1
Length = 316
Score = 126 bits (316), Expect = 3e-028
Identities = 89/258 (34%), Positives = 130/258 (50%), Gaps = 13/258 (5%)
Frame = -2
Query: 981 GLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNGIPGAKLDVMELD 802
G ++TGA++GIG ETAR LA RG V +A R+ G +I +++ V +LD
Sbjct: 39 GKVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIQADTKNSQVLVRKLD 98
Query: 801 LSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHLLLTKFL 622
LS S+R FA + + L++LINNAG+M CP+ + D E A NHLGH LLT L
Sbjct: 99 LSDTKSIRAFAEGFLAEEKQLHILINNAGVMLCPYSKTADGFETHLAVNHLGHFLLTHLL 158
Query: 621 LDTMKNTSRESKREAGL*IYHQKLIGSRIHKSPL**DQRQVKLQ*YASLWT-V*LCNVLH 445
L +K ++ R L L R H D + K + L NVL
Sbjct: 159 LGRLKESA--PARVVNLSSVAHHLGKIRFH------DLQGDKYYNLGFAYCHSKLANVLF 210
Query: 444 ANELAKQLKEDGVNITANSLHPGAIMTNFGRYFNSYLAGAVGAVAKYVLKTVPQGGGTTC 265
ELAK+LK G +T ++HPG + + R+ S+L + + LKT +G T+
Sbjct: 211 TRELAKRLK--GTGVTTYAVHPGIVRSKLVRH--SFLLCLLWRLFSPFLKTTWEGAQTSL 266
Query: 264 YVALNPQVTGVTGEYFLD 211
+ AL + ++G+YF D
Sbjct: 267 HCALAEGLEPLSGKYFSD 284
>sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 OS=Homo sapiens GN=RDH12 PE=1
SV=3
Length = 316
Score = 125 bits (313), Expect = 7e-028
Identities = 84/257 (32%), Positives = 130/257 (50%), Gaps = 11/257 (4%)
Frame = -2
Query: 981 GLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNGIPGAKLDVMELD 802
G ++TGA++GIG ETAR LA RG V +A R+ G +I +++ V +LD
Sbjct: 39 GKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLD 98
Query: 801 LSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHLLLTKFL 622
LS S+R FA + + L++LINNAG+M CP+ + D E NHLGH LLT L
Sbjct: 99 LSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLL 158
Query: 621 LDTMKNTSRESKREAGL*IYHQKLIGSRIHKSPL**DQRQVKLQ*YASLWTV*LCNVLHA 442
L+ +K + A + + + I K P Q + + + L NVL
Sbjct: 159 LERLKVS-------APARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFT 211
Query: 441 NELAKQLKEDGVNITANSLHPGAIMTNFGRYFNSYLAGAVGAVAKYVLKTVPQGGGTTCY 262
ELAK+L+ G +T ++HPG + + R+ S L + + +KT +G T+ +
Sbjct: 212 RELAKRLQ--GTGVTTYAVHPGVVRSELVRH--SSLLCLLWRLFSPFVKTAREGAQTSLH 267
Query: 261 VALNPQVTGVTGEYFLD 211
AL + ++G+YF D
Sbjct: 268 CALAEGLEPLSGKYFSD 284
>sp|O74959|YJCD_SCHPO Uncharacterized oxidoreductase C736.13
OS=Schizosaccharomyces pombe GN=SPCC736.13 PE=2 SV=1
Length = 339
Score = 123 bits (307), Expect = 3e-027
Identities = 95/267 (35%), Positives = 141/267 (52%), Gaps = 14/267 (5%)
Frame = -2
Query: 990 DGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNGIPGAKLDVM 811
D TG A+VTG+S GIG TA LA +G V +A RN KV + I + + +K+ +
Sbjct: 39 DLTGKVALVTGSSGGIGYVTALELARKGAKVYLAGRNEEKYQKVMKQIHDEVRHSKIRFL 98
Query: 810 ELDLSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHLLLT 631
LDL +SV + A + + L++L+NNAGIM PF L+KD ELQ TN+L H L T
Sbjct: 99 RLDLLDFESVYQAAESFIAKEEKLHILVNNAGIMNPPFELTKDGYELQIQTNYLSHYLFT 158
Query: 630 KFLLDTMKNTSRESKREAGL*IYHQKLIG------SRIHKSPL**DQRQVKLQ*YASLWT 469
+ LL T++ T+ E R + I H I S I+ L + V L +A
Sbjct: 159 ELLLPTLRRTAEEC-RPGDVRIVHVASIAYLQAPYSGIYFPDL--NLPHVLLGTFARYGQ 215
Query: 468 V*LCNVLHANELAKQLKEDGVNITANSLHPGAIMTNFGRYFNSY-LAGAVGAVAKYVLKT 292
+L++ LAK+L++ G I + SLHPG I T RY ++ L +V +Y+L
Sbjct: 216 SKYAQILYSIALAKRLEKYG--IYSVSLHPGVIRTELTRYSPTFALKLLEKSVFQYLLLD 273
Query: 291 VPQGGGTTCYVALNPQVT--GVTGEYF 217
+G T+ Y A +P+++ + G YF
Sbjct: 274 PIRGAMTSLYAATSPEISKEHLNGAYF 300
>sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1
SV=2
Length = 331
Score = 103 bits (255), Expect = 4e-021
Identities = 53/125 (42%), Positives = 77/125 (61%)
Frame = -2
Query: 981 GLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNGIPGAKLDVMELD 802
G T IVTGA++GIG +TA LA RG ++++A R+ +DI ++ LD
Sbjct: 38 GKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLD 97
Query: 801 LSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHLLLTKFL 622
L+S+ S+R+FA+ +++LINNAG+M CP ++D E+QF NHLGH LLT L
Sbjct: 98 LASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLL 157
Query: 621 LDTMK 607
LD +K
Sbjct: 158 LDKLK 162
>sp|Q8CEE7|RDH13_MOUSE Retinol dehydrogenase 13 OS=Mus musculus GN=Rdh13 PE=2
SV=1
Length = 334
Score = 97 bits (240), Expect = 2e-019
Identities = 51/125 (40%), Positives = 75/125 (60%)
Frame = -2
Query: 981 GLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNGIPGAKLDVMELD 802
G T IVTGA++GIG +TA LA RG +V++A R+ +DI ++ LD
Sbjct: 38 GKTVIVTGANTGIGKQTALELAKRGGNVILACRDMEKCEVAAKDIRGETLNPRVRAERLD 97
Query: 801 LSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHLLLTKFL 622
L+S+ S+R+FA +++L+NNA +M CP ++D E+QF N+LGH LLT L
Sbjct: 98 LASLKSIREFARKVIKEEERVDILVNNAAVMRCPHWTTEDGFEMQFGVNYLGHFLLTNLL 157
Query: 621 LDTMK 607
LD +K
Sbjct: 158 LDKLK 162
>sp|Q01289|POR_PEA Protochlorophyllide reductase, chloroplastic OS=Pisum sativum
GN=3PCR PE=1 SV=1
Length = 399
Score = 97 bits (239), Expect = 3e-019
Identities = 54/133 (40%), Positives = 82/133 (61%), Gaps = 6/133 (4%)
Frame = -2
Query: 969 IVTGASSGIGVETARVLALRGV-HVVMAVRNTGSGAKVKEDIVNGIPGAKLDVMELDLSS 793
++TGASSG+G+ TA+ LA G HV+MA R+ A+ + G+ +M LDL+S
Sbjct: 90 VITGASSGLGLATAKALAESGKWHVIMACRDYLKAARAAKSA--GLAKENYTIMHLDLAS 147
Query: 792 MDSVRKFASDYKSSGLPLNLLINNAGI---MACPFMLSKDNIELQFATNHLGHLLLTKFL 622
+DSVR+F +++ S +PL++LINNA + A + D E+ TNHLGH LL++ L
Sbjct: 148 LDSVRQFVDNFRRSEMPLDVLINNAAVYFPTAKEPSFTADGFEISVGTNHLGHFLLSRLL 207
Query: 621 LDTMKNTSRESKR 583
L+ +K + SKR
Sbjct: 208 LEDLKKSDYPSKR 220
>sp|Q41249|PORA_CUCSA Protochlorophyllide reductase, chloroplastic OS=Cucumis
sativus GN=PORA PE=2 SV=1
Length = 398
Score = 93 bits (230), Expect = 3e-018
Identities = 54/135 (40%), Positives = 81/135 (60%), Gaps = 6/135 (4%)
Frame = -2
Query: 975 TAIVTGASSGIGVETARVLALRGV-HVVMAVRNTGSGAKVKEDIVNGIPGAKLDVMELDL 799
+ ++TGASSG+G+ TA+ LA G HV+MA R+ + + GI VM LDL
Sbjct: 88 SVVITGASSGLGLATAKALAETGKWHVIMACRDFLKAERAAKSA--GITKENYTVMHLDL 145
Query: 798 SSMDSVRKFASDYKSSGLPLNLLINNAGI---MACPFMLSKDNIELQFATNHLGHLLLTK 628
+S+DSVR+F +++ SG PL++L+ NA + A + + EL TNHLGH LL++
Sbjct: 146 ASLDSVRQFVDNFRQSGRPLDVLVCNAAVYLPTAKEPTFTAEGFELSVGTNHLGHFLLSR 205
Query: 627 FLLDTMKNTSRESKR 583
LL+ + +S SKR
Sbjct: 206 LLLEDLNKSSYPSKR 220
>sp|Q7XKF3|PORA_ORYSJ Protochlorophyllide reductase A, chloroplastic OS=Oryza
sativa subsp. japonica GN=PORA PE=2 SV=1
Length = 387
Score = 91 bits (223), Expect = 2e-017
Identities = 53/133 (39%), Positives = 77/133 (57%), Gaps = 6/133 (4%)
Frame = -2
Query: 969 IVTGASSGIGVETARVLALRGV-HVVMAVRNTGSGAKVKEDIVNGIPGAKLDVMELDLSS 793
++TGASSG+G+ A+ LA G HVVMA R+ A + G+ VM LDL+S
Sbjct: 77 VITGASSGLGLAAAKALAETGKWHVVMACRDFLKAATAAK--AAGMAAGSYTVMHLDLAS 134
Query: 792 MDSVRKFASDYKSSGLPLNLLINNAGI---MACPFMLSKDNIELQFATNHLGHLLLTKFL 622
+DSVR+F +++ SG+PL+ L+ NA I A + D E+ NHLGH LL + +
Sbjct: 135 LDSVRQFVDNFRRSGMPLDALVCNAAIYRPTARQPTFTADGYEMSVGVNHLGHFLLARLM 194
Query: 621 LDTMKNTSRESKR 583
LD +K + S+R
Sbjct: 195 LDDLKKSDYPSRR 207
>sp|Q03326|OXIR_STRAT Probable oxidoreductase OS=Streptomyces antibioticus PE=3
SV=1
Length = 298
Score = 80 bits (196), Expect = 2e-014
Identities = 48/121 (39%), Positives = 68/121 (56%), Gaps = 4/121 (3%)
Frame = -2
Query: 993 VDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNGIPGAKLDV 814
+D TG A+VTG +SG+G ET R LA G V +A R S + +++ ++
Sbjct: 1 MDLTGRRAVVTGGASGLGAETVRALAAAGAEVTVATRRPLSAEPLVQELAAAGGAGRVTA 60
Query: 813 MELDLSSMDSVRKFASDYKSSGLPLNLLINNAGIMACPF-MLSKDNIELQFATNHLGHLL 637
LDLS SV FA ++ PL++L+ NAGIMA P L+ + E+Q ATN+LGH
Sbjct: 61 EALDLSDPASVESFARAWRG---PLDILVANAGIMALPTRTLAPNGWEMQLATNYLGHFA 117
Query: 636 L 634
L
Sbjct: 118 L 118
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,533,745,664
Number of Sequences: 518415
Number of Extensions: 12533745664
Number of Successful Extensions: 80211091
Number of sequences better than 0.0: 0
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