BLASTX 7.6.2
Query= UN03734 /QuerySize=1727
(1726 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9LYT3|TT12_ARATH Protein TRANSPARENT TESTA 12 OS=Arabidopsis... 269 5e-071
sp|Q9USK3|YJ2D_SCHPO Uncharacterized transporter C4B3.13 OS=Schi... 237 3e-061
sp|Q9UT92|YL47_SCHPO Uncharacterized transporter C323.07c OS=Sch... 229 7e-059
sp|Q96FL8|S47A1_HUMAN Multidrug and toxin extrusion protein 1 OS... 209 6e-053
sp|A7KAU3|S47A2_RABIT Multidrug and toxin extrusion protein 2 OS... 208 1e-052
sp|Q5RFD2|S47A1_PONAB Multidrug and toxin extrusion protein 1 OS... 206 4e-052
sp|A7KAU2|S47A1_RABIT Multidrug and toxin extrusion protein 1 OS... 205 9e-052
sp|Q3V050|S47A2_MOUSE Multidrug and toxin extrusion protein 2 OS... 204 2e-051
sp|A4IIS8|S47A1_XENTR Multidrug and toxin extrusion protein 1 OS... 204 2e-051
sp|Q5I0E9|S47A1_RAT Multidrug and toxin extrusion protein 1 OS=R... 202 9e-051
sp|Q8K0H1|S47A1_MOUSE Multidrug and toxin extrusion protein 1 OS... 201 2e-050
sp|A1L1P9|S47A1_DANRE Multidrug and toxin extrusion protein 1 OS... 198 1e-049
sp|Q10085|YAO6_SCHPO Uncharacterized transporter C11D3.06 OS=Sch... 196 7e-049
sp|Q5R7E4|S47A2_PONAB Multidrug and toxin extrusion protein 2 OS... 164 2e-039
sp|Q05497|YD338_YEAST Uncharacterized transporter YDR338C OS=Sac... 162 1e-038
sp|P38767|YHJ2_YEAST Uncharacterized transporter YHR032W OS=Sacc... 102 1e-020
sp|Q86VL8|S47A2_HUMAN Multidrug and toxin extrusion protein 2 OS... 95 2e-018
sp|Q9I3Y3|PMPM_PSEAE Multidrug resistance protein pmpM OS=Pseudo... 66 8e-010
>sp|Q9LYT3|TT12_ARATH Protein TRANSPARENT TESTA 12 OS=Arabidopsis thaliana
GN=TT12 PE=2 SV=1
Length = 507
Score = 269 bits (687), Expect = 5e-071
Identities = 160/407 (39%), Positives = 229/407 (56%), Gaps = 3/407 (0%)
Frame = -2
Query: 1545 KQLW-LAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTFLMGTASA 1369
K LW L+G I VS+L + L ++VMF GHLGSL L+ A++AT + ++G ASA
Sbjct: 53 KLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVGIQGLAYGIMLGMASA 112
Query: 1368 LDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDKAIAHLSG 1189
+ TVCGQ+YGA+ Y +GI QRAM++ +V L+ ++ + L GQ AIAH
Sbjct: 113 VQTVCGQAYGARQYSSMGIICQRAMVLHLAAAVFLTFLYWYSGPILKTMGQSVAIAHEGQ 172
Query: 1188 SYAKFMIPSIFAYGLLQCLNRFLQAQNNVFPVVLCSGVTTCLHVILCWTLVLKSGLGFRG 1009
+A+ MIP I+A+ L + RFLQAQN V P+ S LH +L W + G G
Sbjct: 173 IFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTLLTWLVTNVLDFGLLG 232
Query: 1008 AAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSALMVCLEMW 829
AA+ + S+WL V + Y+ SP+C TWTGFS A R I P+ KL + SA+M+CLE+W
Sbjct: 233 AALILSFSWWLLVAVNGMYILMSPNCKETWTGFSTRAFRGIWPYFKLTVASAVMLCLEIW 292
Query: 828 SFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNELGAGNPKVAK 649
+ LV+ SGLL NP + ++SIC+ GLS A S RVSNELGAGNP+VA
Sbjct: 293 YNQGLVIISGLLSNPTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAM 352
Query: 648 LAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASMLPILALAIA*TAYKV 469
L+V VV +L S ++ ++++ R A++SD EV+ V+ + P+LA++I +
Sbjct: 353 LSVVVVNITTVLISSVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQP 412
Query: 468 FFQG--C*RMWMAEIGAV*SGSYIL*EFLWDCYLVFTFTWVVGGFGW 334
G W A + V +Y + C L F + V G W
Sbjct: 413 ILSGVAIGSGWQAVVAYVNLVTYYVIGLPIGCVLGFKTSLGVAGIWW 459
>sp|Q9USK3|YJ2D_SCHPO Uncharacterized transporter C4B3.13 OS=Schizosaccharomyces
pombe GN=SPCC4B3.13 PE=2 SV=1
Length = 539
Score = 237 bits (603), Expect = 3e-061
Identities = 130/356 (36%), Positives = 204/356 (57%), Gaps = 5/356 (1%)
Frame = -2
Query: 1557 EEVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTFLMGT 1378
+E+ + A P++ SLLQ+ V +V +GHLG L+AA+++ A++T F G
Sbjct: 95 KELTLLIKFATPVVLTSLLQYGEVVTTVFSLGHLGKTELAAASLSNMTATITAFAIYQGI 154
Query: 1377 ASALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDKAIAH 1198
SALDTV QS+G+ YEM+G+ +QR + +L L P+ +IW E L+F QD
Sbjct: 155 VSALDTVGTQSFGSGNYEMVGLHLQRILAILLLIQFPIFLIWWKIEGILLFLRQDPLTCM 214
Query: 1197 LSGSYAKFMIPSIFAYGLLQCLNRFLQAQNNVFPVVLCSGVTTCLHVILCWTLVLKS--G 1024
+ Y + M+ + AY L + L RFLQ Q PV + +++ L + V G
Sbjct: 215 FAAKYMRVMMLASPAYALFEALKRFLQVQGIFHPVTYILAIVVPINIFLNYLFVWSPWVG 274
Query: 1023 LGFRGAAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSALMV 844
GF GA VA A++ W A +L Y+ + W GFS+EAL++ P +LA+P +M+
Sbjct: 275 FGFLGAPVAVALTLWSACAVLIIYI-MKVNGRQAWGGFSREALKNWGPLCRLAVPGVIMI 333
Query: 843 CLEMWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNELGAGN 664
C E W+FE + +SG+L E +S+S+ TS + + FG++ AA+TRV N +GAGN
Sbjct: 334 CSEYWAFELVTFASGVL--GTTELASMSVLSTTSTLSYNLAFGVAAAAATRVGNLIGAGN 391
Query: 663 PKVAKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASMLPILAL 496
K+AKLA V I++ +I+ +L L R W + ++SD +VV VA+++P++AL
Sbjct: 392 TKLAKLATHVSINLGAAIGVIIAVILFLTRNTWTYIFTSDKDVVALVATIIPLVAL 447
>sp|Q9UT92|YL47_SCHPO Uncharacterized transporter C323.07c
OS=Schizosaccharomyces pombe GN=SPAC323.07c PE=1 SV=1
Length = 533
Score = 229 bits (582), Expect = 7e-059
Identities = 130/362 (35%), Positives = 208/362 (57%), Gaps = 9/362 (2%)
Frame = -2
Query: 1563 IKEEVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTFLM 1384
IK E+ + L L P + LLQ Q +V +GHLG L+A++++T A+++ F+
Sbjct: 87 IKHELSELLRLGSPTVIAYLLQSSEQFSTVFTLGHLGKEYLAASSLSTMTAAISAFSIFQ 146
Query: 1383 GTASALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDKAI 1204
G S+LDT+ Q++GA + I +QR +L+L + +P+++IW N EH L+F QD +
Sbjct: 147 GVISSLDTLATQAFGANKPYNVAIYLQRCLLILAVLHIPVALIWLNLEHILIFLHQDPMV 206
Query: 1203 AHLSGSYAKFMIPSIFAYGLLQCLNRFLQAQNNVFPV--VLC--SGVTTCLHVILCWTLV 1036
AHL G Y + I + Y + + L R+LQAQ P+ VLC + + L+ +L W
Sbjct: 207 AHLCGRYMRVFILAAPGYAVFEALKRYLQAQGIFTPITYVLCFAAPLNILLNYLLVWHPT 266
Query: 1035 LKSGLGFRGAAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPS 856
+ G GF GA VA A ++W I L Y+ +S S + W GFS++AL+++ P + +
Sbjct: 267 I--GFGFLGAPVAVATTFWFQSICLILYICFS-STPIPWPGFSRQALKNLSPMLHFSFHG 323
Query: 855 ALMVCLEMWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNEL 676
LM+ E ++E L +G L L +S SI L ++ ++ IPF + A+STRV + +
Sbjct: 324 MLMIVTEWAAYEMTSLGAGYLGTAPL--ASQSILLTSTSLLFQIPFAFAVASSTRVGHLI 381
Query: 675 GAGNPKVAKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASMLPILAL 496
G+G +A+L RV S+A+ SI GS++ R +WG ++SDPEV+ V + PIL+L
Sbjct: 382 GSGRANLARLCSRVAYSLALCISIFDGSLIFCFRDVWGSLFTSDPEVLAVVKDIFPILSL 441
Query: 495 AI 490
I
Sbjct: 442 FI 443
>sp|Q96FL8|S47A1_HUMAN Multidrug and toxin extrusion protein 1 OS=Homo sapiens
GN=SLC47A1 PE=1 SV=1
Length = 570
Score = 209 bits (531), Expect = 6e-053
Identities = 120/359 (33%), Positives = 203/359 (56%), Gaps = 2/359 (0%)
Frame = -2
Query: 1569 SGIKEEVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTF 1390
S +EE++ L LAGP V L+ F + IS +F GHLG L L A +A + +VT +
Sbjct: 29 SAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSV 88
Query: 1389 LMGTASALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDK 1210
G +SA DT+ Q+YG++ + +G+ +QR+ LVL L P ++ NT+H L+ F QD
Sbjct: 89 GFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDP 148
Query: 1209 AIAHLSGSYAKFMIPSIFAYGLLQCLNRFLQAQNNVFPVVLCSGVTTCLHVILCWTLVLK 1030
++ L+ +Y IP++ A L ++L Q V P ++ ++ + + + +
Sbjct: 149 DVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQ 208
Query: 1029 SGLGFRGAAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSAL 850
LG G+A+AN IS + +LL Y+ TW G+S E L+D F++LAIPS L
Sbjct: 209 LHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSML 268
Query: 849 MVCLEMWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNELGA 670
M+C+E W++E SG+L ++E + SI + ++M+P G S AAS RV N LGA
Sbjct: 269 MLCMEWWAYEVGSFLSGIL--GMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGA 326
Query: 669 GNPKVAKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASMLPILALA 493
G+ + A+ + V + I +L ++ +L+ + G+ +++D +++N VA ++PI A++
Sbjct: 327 GDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVS 385
>sp|A7KAU3|S47A2_RABIT Multidrug and toxin extrusion protein 2 OS=Oryctolagus
cuniculus GN=SLC47A2 PE=1 SV=1
Length = 601
Score = 208 bits (529), Expect = 1e-052
Identities = 122/354 (34%), Positives = 191/354 (53%), Gaps = 2/354 (0%)
Frame = -2
Query: 1566 GIKEEVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTFL 1387
G +E + L+GPL +L F V+ +F GHLG + L++ + +F +V +
Sbjct: 55 GFWDEARALFVLSGPLFLFQVLNFLTYVVGTVFCGHLGKVELASVTLGVAFVNVCGVSVG 114
Query: 1386 MGTASALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDKA 1207
G +SA DT+ QS+G+ + +G+ +QR L+L L +P ++ NT+H L+ F QD A
Sbjct: 115 AGLSSACDTLMSQSFGSPNKKHVGVILQRGSLILLLCCLPCWALFLNTQHILLLFRQDPA 174
Query: 1206 IAHLSGSYAKFMIPSIFAYGLLQCLNRFLQAQNNVFPVVLCSGVTTCLHVILCWTLVLKS 1027
++ L+ YA IP + A L L ++LQ Q V+P VL V C++ + + LV
Sbjct: 175 VSRLTQDYAMIFIPGLPAIFLYSLLAKYLQNQGIVWPQVLSGVVGNCVNGVANYALVSVL 234
Query: 1026 GLGFRGAAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSALM 847
LG RG+A AN IS ++ L ++ TW G+S + LRD PF+ LAIPS LM
Sbjct: 235 NLGVRGSAYANTISQFVQAAFLFLHIVLKKLHLETWEGWSSQCLRDWGPFLSLAIPSMLM 294
Query: 846 VCLEMWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNELGAG 667
+C+E W++E GLL V++ S +I + ++MIP GL A RV LGA
Sbjct: 295 MCVEWWAYEIGSFLMGLL--GVVDLSGQAIIYEVATVVYMIPMGLGMAVCVRVGTALGAA 352
Query: 666 NPKVAKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASMLPI 505
+ AK + + S++VG++L L+ G+ ++SD EV+ V +LPI
Sbjct: 353 DTLQAKRSAVSGLLCTAGTSLVVGTLLGLLNSQLGYIFTSDEEVIALVNQVLPI 406
>sp|Q5RFD2|S47A1_PONAB Multidrug and toxin extrusion protein 1 OS=Pongo abelii
GN=SLC47A1 PE=2 SV=1
Length = 570
Score = 206 bits (524), Expect = 4e-052
Identities = 118/359 (32%), Positives = 202/359 (56%), Gaps = 2/359 (0%)
Frame = -2
Query: 1569 SGIKEEVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTF 1390
S +EE++ L LAGP V L+ F + IS +F GHLG L L A +A + +VT +
Sbjct: 29 SAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSV 88
Query: 1389 LMGTASALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDK 1210
G +SA DT+ Q+YG++ + +G+ +QR+ L+L L P ++ NT+H L+ F QD
Sbjct: 89 GFGLSSACDTLISQTYGSQNLKHVGVILQRSALILLLCCFPCWALFLNTQHILLLFRQDP 148
Query: 1209 AIAHLSGSYAKFMIPSIFAYGLLQCLNRFLQAQNNVFPVVLCSGVTTCLHVILCWTLVLK 1030
++ L+ +Y IP++ A L ++L Q V P ++ ++ + + + +
Sbjct: 149 DVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQ 208
Query: 1029 SGLGFRGAAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSAL 850
LG G+A+AN IS + +LL Y+ TW G+S E L+D F+ LA+PS L
Sbjct: 209 LHLGAIGSALANLISQYTLALLLFFYILGKKLHQATWGGWSLECLQDWASFLHLAVPSML 268
Query: 849 MVCLEMWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNELGA 670
M+C+E W++E SG+L ++E + SI + ++M+P G S AAS RV N LGA
Sbjct: 269 MLCMEWWAYEVGSFLSGIL--GMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGA 326
Query: 669 GNPKVAKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASMLPILALA 493
G+ + A+ + V + I +L ++ +L+ + G+ +++D +++N VA ++PI A++
Sbjct: 327 GDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVS 385
>sp|A7KAU2|S47A1_RABIT Multidrug and toxin extrusion protein 1 OS=Oryctolagus
cuniculus GN=SLC47A1 PE=2 SV=1
Length = 568
Score = 205 bits (521), Expect = 9e-052
Identities = 116/359 (32%), Positives = 200/359 (55%), Gaps = 2/359 (0%)
Frame = -2
Query: 1569 SGIKEEVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTF 1390
S +EE++ L LA P L+ F + +S +F GHL L L+A +A + +V +
Sbjct: 28 SDFREELRALLVLACPAFLAQLMVFLISFVSSVFCGHLSKLELNAVTLAIAVINVMGVSV 87
Query: 1389 LMGTASALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDK 1210
G +SA DT+ Q+YG++ + +G+ +QR L+L L +P ++ NT+H L+ F QD
Sbjct: 88 GFGLSSACDTLISQTYGSRNLKHVGVILQRGSLILLLCCLPCWALFLNTQHILLLFRQDP 147
Query: 1209 AIAHLSGSYAKFMIPSIFAYGLLQCLNRFLQAQNNVFPVVLCSGVTTCLHVILCWTLVLK 1030
A++ L+ +Y IP++ A L ++L Q V P V+ ++ + + V +
Sbjct: 148 AVSRLTQTYVTIFIPALPATFLYTLQVKYLLNQGIVLPQVVTGVAANLVNALANYLFVYQ 207
Query: 1029 SGLGFRGAAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSAL 850
LG G+A+AN ++ + +LL Y+ S TW G+S E L+D F +LAIPS L
Sbjct: 208 LHLGVMGSALANTVAQFTLALLLFLYILRSKVYQATWGGWSLECLQDWASFFRLAIPSML 267
Query: 849 MVCLEMWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNELGA 670
M+C+E W++E SG+L ++E + S+ + ++MIP GLS A + RV N LGA
Sbjct: 268 MLCMEWWAYEIGSFLSGIL--GMVELGAQSVTYELAVIVYMIPMGLSVAVNVRVGNALGA 325
Query: 669 GNPKVAKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASMLPILALA 493
GN + AK + V + + L +++ +L+ + + G+ ++SD +++ VA + PI A++
Sbjct: 326 GNIEQAKKSSAVALLVTELIAVVFCVMLLSCKDLVGYIFTSDRDIIALVAQVTPIYAVS 384
>sp|Q3V050|S47A2_MOUSE Multidrug and toxin extrusion protein 2 OS=Mus musculus
GN=Slc47a2 PE=1 SV=1
Length = 573
Score = 204 bits (518), Expect = 2e-051
Identities = 116/355 (32%), Positives = 193/355 (54%), Gaps = 2/355 (0%)
Frame = -2
Query: 1563 IKEEVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTFLM 1384
++ E + LAGP+ L+ F + ++S +F GHLG + L A +A S +VT +
Sbjct: 40 VRREAAALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGISVGT 99
Query: 1383 GTASALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDKAI 1204
G ASA DT+ QS+G K + +G+ +QR +L+L L P I+ NTE L+ QD +
Sbjct: 100 GLASACDTLMSQSFGGKNLKRVGVILQRGILILLLCCFPCWAIFLNTERLLLLLRQDPDV 159
Query: 1203 AHLSGSYAKFMIPSIFAYGLLQCLNRFLQAQNNVFPVVLCSGVTTCLHVILCWTLVLKSG 1024
A L+ Y IP++ A L Q R+LQ+Q + P V+ ++V + L+
Sbjct: 160 ARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAFLLYALD 219
Query: 1023 LGFRGAAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSALMV 844
LG G+A AN S + LL YV + TW G+++E ++ + +LAIPS MV
Sbjct: 220 LGVVGSAWANTTSQFFLSALLFLYVWWKRIHIHTWGGWTRECFQEWSSYTRLAIPSMFMV 279
Query: 843 CLEMWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNELGAGN 664
C+E W+FE +GL+ V E + ++ + +M+PFG AAS RV N LGAGN
Sbjct: 280 CIEWWTFEIGTFLAGLV--NVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGN 337
Query: 663 PKVAKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASMLPILA 499
A+ + V+ A + +++VG +L ++ + + +++D ++++ V+ ++PI A
Sbjct: 338 ADQARCSCTTVLLCAGVCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFA 392
>sp|A4IIS8|S47A1_XENTR Multidrug and toxin extrusion protein 1 OS=Xenopus
tropicalis GN=slc47a1 PE=2 SV=1
Length = 574
Score = 204 bits (517), Expect = 2e-051
Identities = 110/356 (30%), Positives = 202/356 (56%), Gaps = 2/356 (0%)
Frame = -2
Query: 1557 EEVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTFLMGT 1378
+E ++ L LA P L+ F + ++S +F GHLG + L A ++A + ++T G
Sbjct: 47 QEAQQLLALAAPAFLSQLMIFLISIVSSIFCGHLGKVELDAVSLAITIINITGVAVGTGL 106
Query: 1377 ASALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDKAIAH 1198
A A DT+ Q++G +++GI +QR +L+L L+ P + NTE L+ F QD ++
Sbjct: 107 AGACDTLISQTFGGSNLKLVGIILQRGILILLLFCFPCWALLINTESILLLFRQDPEVSK 166
Query: 1197 LSGSYAKFMIPSIFAYGLLQCLNRFLQAQNNVFPVVLCSGVTTCLHVILCWTLVLKSGLG 1018
L+ Y +P++ A L Q L ++LQ Q ++P VL + + + + L+ GLG
Sbjct: 167 LTQIYVLIFLPALPAAFLYQLLAKYLQNQGIIYPQVLTGFIANIFNALFNYILLYVLGLG 226
Query: 1017 FRGAAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSALMVCL 838
G+A AN +S ++ +ILL Y+ + + TW G+S+ + F++LA+ S LM+C+
Sbjct: 227 VMGSACANTVSQFIQMILLFLYIVWRRLYADTWGGWSQACFEEWGAFIRLAVASMLMLCI 286
Query: 837 EMWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNELGAGNPK 658
E W+FE + +G+L +++ ++ +I + +++IP GL A S RV + LGAGN +
Sbjct: 287 EWWAFEISMFLAGVL--GMVDLAAQAIIYQVAIVVYLIPLGLCIAGSIRVGHGLGAGNTE 344
Query: 657 VAKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASMLPILALAI 490
AK + VV+ + L +++ G +L ++ + + ++SDP +V V+ +LP+ + +
Sbjct: 345 QAKRSALVVLCMTELCALLSGILLATLKDVVAYIFTSDPNIVALVSYVLPVYSACL 400
>sp|Q5I0E9|S47A1_RAT Multidrug and toxin extrusion protein 1 OS=Rattus
norvegicus GN=Slc47a1 PE=1 SV=1
Length = 566
Score = 202 bits (512), Expect = 9e-051
Identities = 120/359 (33%), Positives = 199/359 (55%), Gaps = 2/359 (0%)
Frame = -2
Query: 1569 SGIKEEVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTF 1390
SG +EE++ L LAGP L+ F + IS +F GHLG L L A +A + +VT +
Sbjct: 28 SGFQEELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISV 87
Query: 1389 LMGTASALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDK 1210
G +SA DT+ Q+YG++ + +G+ +QR L+L L P ++ NTE L+ F QD
Sbjct: 88 GHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWALFINTEQILLLFRQDP 147
Query: 1209 AIAHLSGSYAKFMIPSIFAYGLLQCLNRFLQAQNNVFPVVLCSGVTTCLHVILCWTLVLK 1030
++ L+ +Y IP++ A L ++L Q V P V+ ++ + + + +
Sbjct: 148 DVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIAANLVNALANYLFLHQ 207
Query: 1029 SGLGFRGAAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSAL 850
LG G+A+AN IS + I L Y+ + TW G+S E L+D F++LAIPS L
Sbjct: 208 LHLGVMGSALANTISQFALAIFLFLYILWRKLHHATWGGWSWECLQDWASFLQLAIPSML 267
Query: 849 MVCLEMWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNELGA 670
M+C+E W++E SG+L ++E + SI + ++MIP G S AA+ RV N LGA
Sbjct: 268 MLCIEWWAYEVGSFLSGIL--GMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGA 325
Query: 669 GNPKVAKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASMLPILALA 493
GN AK + + + + L ++ +L+ + + G+ +++D ++V VA ++PI A++
Sbjct: 326 GNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVS 384
>sp|Q8K0H1|S47A1_MOUSE Multidrug and toxin extrusion protein 1 OS=Mus musculus
GN=Slc47a1 PE=1 SV=2
Length = 567
Score = 201 bits (510), Expect = 2e-050
Identities = 118/358 (32%), Positives = 196/358 (54%), Gaps = 2/358 (0%)
Frame = -2
Query: 1566 GIKEEVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTFL 1387
G EE++ L LAGP L+ F + IS +F GHLG L L A +A + +VT +
Sbjct: 30 GFLEELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVG 89
Query: 1386 MGTASALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDKA 1207
G +SA DT+ Q+YG++ + +G+ +QR L+L L P ++ NTE L+ F QD
Sbjct: 90 HGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWALFINTEQILLLFRQDPD 149
Query: 1206 IAHLSGSYAKFMIPSIFAYGLLQCLNRFLQAQNNVFPVVLCSGVTTCLHVILCWTLVLKS 1027
++ L+ +Y IP++ A L ++L Q V P ++ ++ + + +
Sbjct: 150 VSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLYHL 209
Query: 1026 GLGFRGAAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSALM 847
LG G+A+AN IS + I L Y+ + TW G+S E L+D F++LAIPS LM
Sbjct: 210 HLGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASFLRLAIPSMLM 269
Query: 846 VCLEMWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNELGAG 667
+C+E W++E SG+L ++E + SI + ++MIP G S AA+ RV N LGAG
Sbjct: 270 LCIEWWAYEVGSFLSGIL--GMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAG 327
Query: 666 NPKVAKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASMLPILALA 493
N AK + + + + L ++ +L+ + + G+ +++D ++V VA ++PI A++
Sbjct: 328 NIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVS 385
>sp|A1L1P9|S47A1_DANRE Multidrug and toxin extrusion protein 1 OS=Danio rerio
GN=slc47a1 PE=2 SV=1
Length = 590
Score = 198 bits (503), Expect = 1e-049
Identities = 110/350 (31%), Positives = 193/350 (55%), Gaps = 2/350 (0%)
Frame = -2
Query: 1560 KEEVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTFLMG 1381
K E+ + L LAGP+ L+ F + +S +F GHLG L+ A+A + +VT + G
Sbjct: 50 KTEIVELLKLAGPVFISQLMIFLISFVSTVFCGHLGKTELAGVALAIAVINVTGISIGSG 109
Query: 1380 TASALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDKAIA 1201
ASA DT+ Q++G+ + +G+ +QR +L+L L P + NTE L+ Q +A
Sbjct: 110 LASACDTLISQTFGSNNLKRVGVILQRGILILLLACFPCWALLINTEPILLAVRQSPNVA 169
Query: 1200 HLSGSYAKFMIPSIFAYGLLQCLNRFLQAQNNVFPVVLCSGVTTCLHVILCWTLVLKSGL 1021
LS Y K +P++ A + Q R+LQ Q ++P V+ L+ ++ + + L
Sbjct: 170 SLSQLYVKIFMPALPAAFMYQLQGRYLQNQGIIWPQVITGAAGNILNALINYVFLHLLEL 229
Query: 1020 GFRGAAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSALMVC 841
G G+A AN IS + + L Y+R+ TW G+S++ L++ F++LA+PS LM+C
Sbjct: 230 GVAGSAAANTISQYSLAVFLYVYIRWKNLHKATWDGWSRDCLQEWGAFIRLALPSMLMLC 289
Query: 840 LEMWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNELGAGNP 661
+E W++E +GL+ E + S+ + +M P G + AAS RV N LGAGN
Sbjct: 290 VEWWTYEIGGFLAGLISE--TELGAQSVVYELATIAYMFPLGFAVAASVRVGNALGAGNT 347
Query: 660 KVAKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASML 511
+ AKL+ +V + +L S +V +++ + + + ++++ E+V+ V+ ++
Sbjct: 348 ERAKLSAKVALVCGVLVSCVVATLIGCTKDVIAYIFTTEEEIVSRVSQVM 397
>sp|Q10085|YAO6_SCHPO Uncharacterized transporter C11D3.06
OS=Schizosaccharomyces pombe GN=SPAC11D3.06 PE=2 SV=1
Length = 455
Score = 196 bits (496), Expect = 7e-049
Identities = 118/352 (33%), Positives = 188/352 (53%), Gaps = 3/352 (0%)
Frame = -2
Query: 1554 EVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTFLMGTA 1375
EVK L + P+I LQ LQ SV+ G LG LS AA A FA T + +G
Sbjct: 7 EVKYLLINSAPVILGYALQNSLQTSSVIVTGRLGPSELSVAAFAYMFAMSTGWLIALGGT 66
Query: 1374 SALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDKAIAHL 1195
+A DT+ +GA + LGI +Q +VL++ +P+ ++W ++ L+F Q +A
Sbjct: 67 TAFDTLGSNLWGAGKKQELGILLQTGFIVLSILYLPICLVWWYSKPILIFLHQTPELAEA 126
Query: 1194 SGSYAKFMIPSIFAYGLLQCLNRFLQAQNNVFPVVLCSGVTTCLHVILCWTLVLKSGLGF 1015
S + +++IP Y + L +FLQ Q VT+ L+V L + LV GLG
Sbjct: 127 SQKFLRYLIPGGLGYVCFELLKKFLQTQEITRAGSYILLVTSPLNVALNFLLVHYYGLGL 186
Query: 1014 RGAAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSALMVCLE 835
+GA +A +SYWL+ ILL+ Y +Y W G++K L + PF+KL++ +MV E
Sbjct: 187 KGAPLATGLSYWLSFILLTQYAKYVKGAE-AWNGWNKRCLENFGPFVKLSLLGIVMVGTE 245
Query: 834 MWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNELGAGNPKV 655
W+FE + L +G L + ++ S+ + T + IPFGL S RV+ LGAG P
Sbjct: 246 WWAFEIVALVAGKL--GAVPLAAQSVIMTTDQLLNTIPFGLGIITSNRVAYYLGAGLPDN 303
Query: 654 AKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASMLPILA 499
A L +V + + ++ +I +R I+G +++DP+V+ VA ++P++A
Sbjct: 304 ASLTAKVAAIVGVAVGSVIMITMIAVRNIYGRIFTNDPDVIQLVALVMPLVA 355
>sp|Q5R7E4|S47A2_PONAB Multidrug and toxin extrusion protein 2 OS=Pongo abelii
GN=SLC47A2 PE=2 SV=1
Length = 581
Score = 164 bits (414), Expect = 2e-039
Identities = 90/269 (33%), Positives = 147/269 (54%), Gaps = 2/269 (0%)
Frame = -2
Query: 1533 LAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTFLMGTASALDTVC 1354
L+GPL +L F + ++S +F GHLG + L++ +A +F +V + +G +SA DT+
Sbjct: 37 LSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLM 96
Query: 1353 GQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDKAIAHLSGSYAKF 1174
QS+G+ + +G+ +QR LVL L +P ++ NT+H L+ F QD ++ L+ Y
Sbjct: 97 SQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPEVSRLTQDYVMI 156
Query: 1173 MIPSIFAYGLLQCLNRFLQAQNNVFPVVLCSGVTTCLHVILCWTLVLKSGLGFRGAAVAN 994
IP + L L ++LQ Q +P VL V C++ + + LV LG RG+A AN
Sbjct: 157 FIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYAN 216
Query: 993 AISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSALMVCLEMWSFEFL 814
IS + + L Y+ TW G+S + L+D PF LA+PS LM+C+E W++E
Sbjct: 217 IISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIG 276
Query: 813 VLSSGLLPNPVLETSSLSICLNTSGTIWM 727
GLL V++ S+ ++ + +M
Sbjct: 277 SFLMGLL--SVVDLSAQAVIYEVATVTYM 303
>sp|Q05497|YD338_YEAST Uncharacterized transporter YDR338C OS=Saccharomyces
cerevisiae GN=YDR338C PE=1 SV=1
Length = 695
Score = 162 bits (408), Expect = 1e-038
Identities = 102/359 (28%), Positives = 183/359 (50%), Gaps = 10/359 (2%)
Frame = -2
Query: 1560 KEEVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTFLMG 1381
K E + + PLI LL+ ++ + VGHLG L+A ++A+ +++T F G
Sbjct: 226 KSEARVLASYSFPLIFTFLLEQIFPMVCSLTVGHLGKNELAAVSLASMTSNITLAIF-EG 284
Query: 1380 TASALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDKAIA 1201
A++LDT+C Q+YG+ + +G+ +QR + + +P +++W +E L + +K +
Sbjct: 285 IATSLDTLCPQAYGSGRFYSVGVHLQRCIAFSLVIYIPFAVMWWYSEPLLSYIIPEKELI 344
Query: 1200 HLSGSYAKFMIPSIFAYGLLQCLNRFLQAQN----NVFPVVLCSGVTTCLHVILCWTLVL 1033
+L+ + + +I AY + L RFLQAQ ++ + +C+ + + L W +
Sbjct: 345 NLTSRFLRVLILGAPAYIFFENLKRFLQAQGIFDAGIYVLTICAPLNVLVSYTLVWNKYI 404
Query: 1032 KSGLGFRGAAVANAISYWLAVILLSCYVRYSPSCSMTWTGFSKEALRDIIPFMKLAIPSA 853
G+GF GAA+A +++WL LL Y Y W GFS++A LA
Sbjct: 405 --GVGFIGAAIAVVLNFWLMFFLLLFYALYIDG-RKCWGGFSRKAFTHWNDLGHLAFSGI 461
Query: 852 LMVCLEMWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGAASTRVSNELG 673
+M+ E S+E L L S V ++ S + ++MIPF + + STR++N +G
Sbjct: 462 IMLEAEELSYELLTLFSAYY--GVSYLAAQSAVSTMAALLYMIPFAIGISTSTRIANFIG 519
Query: 672 AGNPKVAKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFVASMLPILAL 496
A A ++ +V +S + + I +L+ R + YS DPEV+ +A +LP++ +
Sbjct: 520 AKRTDFAHISSQVGLSFSFIAGFINCCILVFGRNLIANIYSKDPEVIKLIAQVLPLVGI 578
>sp|P38767|YHJ2_YEAST Uncharacterized transporter YHR032W OS=Saccharomyces
cerevisiae GN=YHR032W PE=1 SV=1
Length = 581
Score = 102 bits (253), Expect = 1e-020
Identities = 59/208 (28%), Positives = 105/208 (50%), Gaps = 7/208 (3%)
Frame = -2
Query: 1560 KEEVKKQLWLAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTFLMG 1381
K E + A PLI +LQ L + S+ V HLG+ L + + A++T + G
Sbjct: 162 KRETQVITMNALPLIFTFILQNSLSLASIFSVSHLGTKELGGVTLGSMTANITGLAAIQG 221
Query: 1380 TASALDTVCGQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIW-ANTEHFLVFFGQDKAI 1204
+ LDT+C Q+YGAK Y ++G+ +QR ++ L +P+ +W +E L ++ +
Sbjct: 222 LCTCLDTLCAQAYGAKNYHLVGVLVQRCAVITILAFLPMMYVWFVWSEKILALMIPEREL 281
Query: 1203 AHLSGSYAKFMIPSIFAYGLLQCLNRFLQAQN----NVFPVVLCSGVTTCLHVILCWTLV 1036
L+ +Y + + + L +C RFLQ Q + + +C+ + ++ +L W
Sbjct: 282 CALAANYLRVTAFGVPGFILFECGKRFLQCQGIFHASTIVLFVCAPLNALMNYLLVWN-- 339
Query: 1035 LKSGLGFRGAAVANAISYWLAVILLSCY 952
K G+G+ GA ++ I+YWL + L Y
Sbjct: 340 DKIGIGYLGAPLSVVINYWLMTLGLLIY 367
>sp|Q86VL8|S47A2_HUMAN Multidrug and toxin extrusion protein 2 OS=Homo sapiens
GN=SLC47A2 PE=1 SV=1
Length = 602
Score = 95 bits (234), Expect = 2e-018
Identities = 48/141 (34%), Positives = 81/141 (57%)
Frame = -2
Query: 1533 LAGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAAAVATSFASVTCFTFLMGTASALDTVC 1354
L+GPL +L F + ++S +F GHLG + L++ +A +F +V + +G +SA DT+
Sbjct: 37 LSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLM 96
Query: 1353 GQSYGAKMYEMLGIQMQRAMLVLTLYSVPLSIIWANTEHFLVFFGQDKAIAHLSGSYAKF 1174
QS+G+ + +G+ +QR LVL L +P ++ NT+H L+ F QD ++ L+ Y
Sbjct: 97 SQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMI 156
Query: 1173 MIPSIFAYGLLQCLNRFLQAQ 1111
IP + L L ++LQ Q
Sbjct: 157 FIPGLPVIFLYNLLAKYLQNQ 177
>sp|Q9I3Y3|PMPM_PSEAE Multidrug resistance protein pmpM OS=Pseudomonas
aeruginosa GN=pmpM PE=3 SV=1
Length = 477
Score = 66 bits (159), Expect = 8e-010
Identities = 41/129 (31%), Positives = 68/129 (52%), Gaps = 2/129 (1%)
Frame = -2
Query: 882 PFMKLAIPSALMVCLEMWSFEFLVLSSGLLPNPVLETSSLSICLNTSGTIWMIPFGLSGA 703
P + + +P + V E F + L G L V+ + I LN S ++MIP+ L A
Sbjct: 247 PLVAVGLPIGIAVFAESSIFSVIALLIGGLDENVV--AGHQIALNFSALVFMIPYSLGMA 304
Query: 702 ASTRVSNELGAGNPKVAKLAVRVVISIAILESIIVGSVLILIRKIWGFAYSSDPEVVNFV 523
+ RV + LGAG P+ A+ A V ++ A+ + + S+++L+R+ YS DP V+
Sbjct: 305 VTVRVGHNLGAGLPRDARFAAGVGMAAALGYACVSASLMLLLREQIAAMYSPDPAVIAIA 364
Query: 522 ASMLPILAL 496
AS++ AL
Sbjct: 365 ASLIVFSAL 373
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,545,185,555
Number of Sequences: 518415
Number of Extensions: 16545185555
Number of Successful Extensions: 102511304
Number of sequences better than 0.0: 0
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