BLASTX 7.6.2
Query= UN03805 /QuerySize=854
(853 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9D1D4|TMEDA_MOUSE Transmembrane emp24 domain-containing prot... 109 4e-023
sp|Q5E971|TMEDA_BOVIN Transmembrane emp24 domain-containing prot... 105 5e-022
sp|Q28735|TMEDA_RABIT Transmembrane emp24 domain-containing prot... 104 1e-021
sp|Q63584|TMEDA_RAT Transmembrane emp24 domain-containing protei... 104 1e-021
sp|P49755|TMEDA_HUMAN Transmembrane emp24 domain-containing prot... 103 2e-021
sp|Q5RE32|TMEDA_PONAB Transmembrane emp24 domain-containing prot... 103 2e-021
sp|O35587|TMEDA_MESAU Transmembrane protein Tmp21 OS=Mesocricetu... 102 3e-021
sp|Q90515|TMEDA_TAKRU Transmembrane emp24 domain-containing prot... 101 7e-021
sp|B4NIY1|TMEDA_DROWI Transmembrane emp24 domain-containing prot... 98 7e-020
sp|B3LVB0|TMEDA_DROAN Transmembrane emp24 domain-containing prot... 97 2e-019
sp|B4JYU5|TMEDA_DROGR Transmembrane emp24 domain-containing prot... 95 5e-019
sp|A0AQ71|TMEDA_DROSI Transmembrane emp24 domain-containing prot... 94 1e-018
sp|B3P6T8|TMEDA_DROER Transmembrane emp24 domain-containing prot... 94 1e-018
sp|B4PUZ3|TMEDA_DROYA Transmembrane emp24 domain-containing prot... 94 1e-018
sp|B4K4G5|TMEDA_DROMO Transmembrane emp24 domain-containing prot... 93 2e-018
sp|Q8SXY6|TMEDA_DROME Transmembrane emp24 domain-containing prot... 92 3e-018
sp|B4GE47|TMEDA_DROPE Transmembrane emp24 domain-containing prot... 92 3e-018
sp|B4MGF8|TMEDA_DROVI Transmembrane emp24 domain-containing prot... 92 3e-018
sp|Q9D2R4|TMD11_MOUSE Transmembrane emp24 domain-containing prot... 70 2e-011
sp|Q4WQL0|TMEDA_ASPFU Endoplasmic reticulum vesicle protein 25 O... 67 1e-010
>sp|Q9D1D4|TMEDA_MOUSE Transmembrane emp24 domain-containing protein 10 OS=Mus
musculus GN=Tmed10 PE=2 SV=1
Length = 219
Score = 109 bits (270), Expect = 4e-023
Identities = 58/208 (27%), Positives = 110/208 (52%), Gaps = 5/208 (2%)
Frame = +3
Query: 66 NTWTFLLTLAIISGVSQSLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSH 245
+ W FLL L S + S H + S KC+ E+I + + G Y + +H
Sbjct: 16 SAWLFLLLLGPSSVLGISFHLPVNS--RKCLREEIHKDLLVTGAYEITDQSGGAGGLRTH 73
Query: 246 KISIRVTSSYGNTFHHAEDVDSGQFAFTAVEAGDYMACFTANGHKPEVTLSIDFDWRTGI 425
+++T S G+ + ED G+FAFT + + CF + G + D + G+
Sbjct: 74 ---LKITDSAGHILYAKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGV 130
Query: 426 HSKSWSSVAKKSQVEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLS 605
+K++ +AK +++ +E E+++L + +I ++ Y++ REEEM++ N +TN+++ + S
Sbjct: 131 EAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFS 190
Query: 606 FLSLFVCLGVAGMQFMHLKTFLEKKKVI 689
S+F +G+A Q +L+ F + KK+I
Sbjct: 191 IFSMFCLIGLATWQVFYLRRFFKAKKLI 218
>sp|Q5E971|TMEDA_BOVIN Transmembrane emp24 domain-containing protein 10 OS=Bos
taurus GN=TMED10 PE=2 SV=1
Length = 219
Score = 105 bits (261), Expect = 5e-022
Identities = 56/206 (27%), Positives = 109/206 (52%), Gaps = 5/206 (2%)
Frame = +3
Query: 78 FLLTLAIISGVSQ--SLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKI 251
F L L ++ G S ++ F L KC+ E+I + + G Y + +H
Sbjct: 16 FALLLLLLLGPSSVLAISFHLPVNSRKCLREEIHKDLLVTGAYEITDQSGGAGGLRTH-- 73
Query: 252 SIRVTSSYGNTFHHAEDVDSGQFAFTAVEAGDYMACFTANGHKPEVTLSIDFDWRTGIHS 431
+++T S G+ + ED G+FAFT + + CF + G + D + G+ +
Sbjct: 74 -LKITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEA 132
Query: 432 KSWSSVAKKSQVEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSFL 611
K++ +AK +++ +E E+++L + +I ++ Y++ REEEM++ N +TN+++ + S
Sbjct: 133 KNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIF 192
Query: 612 SLFVCLGVAGMQFMHLKTFLEKKKVI 689
S+F +G+A Q +L+ F + KK+I
Sbjct: 193 SMFCLIGLATWQVFYLRRFFKAKKLI 218
>sp|Q28735|TMEDA_RABIT Transmembrane emp24 domain-containing protein 10
OS=Oryctolagus cuniculus GN=TMED10 PE=1 SV=1
Length = 219
Score = 104 bits (258), Expect = 1e-021
Identities = 56/204 (27%), Positives = 108/204 (52%), Gaps = 5/204 (2%)
Frame = +3
Query: 78 FLLTLAIISGVSQSLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKISI 257
FL L S ++ S H + S KC+ E+I + + G Y + +H +
Sbjct: 20 FLFLLGPSSVLAISFHLPVNS--RKCLREEIHKDLLVTGAYEITDQSGGAGGLRTH---L 74
Query: 258 RVTSSYGNTFHHAEDVDSGQFAFTAVEAGDYMACFTANGHKPEVTLSIDFDWRTGIHSKS 437
++T S G+ + ED G+FAFT + + CF + G + D + G+ +K+
Sbjct: 75 KITDSAGHILYSKEDASKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKN 134
Query: 438 WSSVAKKSQVEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSFLSL 617
+ +AK +++ +E E+++L + +I ++ Y++ REEEM++ N +TN+++ + S S+
Sbjct: 135 YEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSM 194
Query: 618 FVCLGVAGMQFMHLKTFLEKKKVI 689
F +G+A Q +L+ F + KK+I
Sbjct: 195 FCLIGLATWQVFYLRRFFKAKKLI 218
>sp|Q63584|TMEDA_RAT Transmembrane emp24 domain-containing protein 10 OS=Rattus
norvegicus GN=Tmed10 PE=1 SV=2
Length = 219
Score = 104 bits (258), Expect = 1e-021
Identities = 58/212 (27%), Positives = 111/212 (52%), Gaps = 7/212 (3%)
Frame = +3
Query: 54 LRSENTWTFLLTLAIISGVSQSLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPS 233
L S + FLL + + G+S F L KC+ E+I + + G Y +
Sbjct: 14 LLSALLFLFLLGPSSVLGIS----FHLPVNSRKCLREEIHKDLLVTGAYEITDQSGGAGG 69
Query: 234 PPSHKISIRVTSSYGNTFHHAEDVDSGQFAFTAVEAGDYMACFTANGHKPEVTLSIDFDW 413
+H +++T S G+ + ED G+FAFT + + CF + G + D
Sbjct: 70 LRTH---LKITDSAGHILYAKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDM 126
Query: 414 RTGIHSKSWSSVAKKSQVEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKM 593
+ G+ +K++ +AK +++ +E E+++L + +I ++ Y++ REEEM++ N +TN+++
Sbjct: 127 KHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRV 186
Query: 594 AWLSFLSLFVCLGVAGMQFMHLKTFLEKKKVI 689
+ S S+F +G+A Q +L+ F + KK+I
Sbjct: 187 LYFSIFSMFCLIGLATWQVFYLRRFFKAKKLI 218
>sp|P49755|TMEDA_HUMAN Transmembrane emp24 domain-containing protein 10 OS=Homo
sapiens GN=TMED10 PE=1 SV=2
Length = 219
Score = 103 bits (255), Expect = 2e-021
Identities = 56/204 (27%), Positives = 107/204 (52%), Gaps = 7/204 (3%)
Frame = +3
Query: 78 FLLTLAIISGVSQSLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKISI 257
FLL ++ +S F L KC+ E+I + + G Y + SH +
Sbjct: 22 FLLGPRLVLAIS----FHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSH---L 74
Query: 258 RVTSSYGNTFHHAEDVDSGQFAFTAVEAGDYMACFTANGHKPEVTLSIDFDWRTGIHSKS 437
++T S G+ + ED G+FAFT + + CF + G + D + G+ +K+
Sbjct: 75 KITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKN 134
Query: 438 WSSVAKKSQVEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSFLSL 617
+ +AK +++ +E E+++L + +I ++ Y++ REEEM++ N +TN+++ + S S+
Sbjct: 135 YEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSM 194
Query: 618 FVCLGVAGMQFMHLKTFLEKKKVI 689
F +G+A Q +L+ F + KK+I
Sbjct: 195 FCLIGLATWQVFYLRRFFKAKKLI 218
>sp|Q5RE32|TMEDA_PONAB Transmembrane emp24 domain-containing protein 10 OS=Pongo
abelii GN=TMED10 PE=2 SV=1
Length = 219
Score = 103 bits (255), Expect = 2e-021
Identities = 56/204 (27%), Positives = 107/204 (52%), Gaps = 7/204 (3%)
Frame = +3
Query: 78 FLLTLAIISGVSQSLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKISI 257
FLL +++ +S F L KC+ E+I + + G Y + SH +
Sbjct: 22 FLLGPSLVLAIS----FHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSH---L 74
Query: 258 RVTSSYGNTFHHAEDVDSGQFAFTAVEAGDYMACFTANGHKPEVTLSIDFDWRTGIHSKS 437
++T S G+ + ED G+FAFT + + CF + G + D + G+ +K+
Sbjct: 75 KITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKN 134
Query: 438 WSSVAKKSQVEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSFLSL 617
+ +AK +++ +E E+++L + +I ++ Y+ REEEM++ N +TN+++ + S S+
Sbjct: 135 YEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMEKREEEMRDTNESTNTRVLYFSIFSM 194
Query: 618 FVCLGVAGMQFMHLKTFLEKKKVI 689
F +G+A Q +L+ F + KK+I
Sbjct: 195 FCLIGLATWQVFYLRRFFKAKKLI 218
>sp|O35587|TMEDA_MESAU Transmembrane protein Tmp21 OS=Mesocricetus auratus
GN=TMED10 PE=2 SV=1
Length = 219
Score = 102 bits (254), Expect = 3e-021
Identities = 56/204 (27%), Positives = 108/204 (52%), Gaps = 5/204 (2%)
Frame = +3
Query: 78 FLLTLAIISGVSQSLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKISI 257
FLL L S ++ S H + S KC+ E+I + + G Y + +H +
Sbjct: 20 FLLLLGPSSVLAISFHLPVNS--RKCLREEIHKDLLVTGAYEITDQSGGAGGLRTH---L 74
Query: 258 RVTSSYGNTFHHAEDVDSGQFAFTAVEAGDYMACFTANGHKPEVTLSIDFDWRTGIHSKS 437
++T S G+ + ED G+FAFT + + CF + G + D + G+ +K+
Sbjct: 75 KITDSAGHILYAKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKN 134
Query: 438 WSSVAKKSQVEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSFLSL 617
+ +AK +++ +E E+++L + +I ++ Y++ REEEM++ N +TN+++ + S S+
Sbjct: 135 YEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSM 194
Query: 618 FVCLGVAGMQFMHLKTFLEKKKVI 689
+G+A Q +L+ F + KK+I
Sbjct: 195 LCLIGLATWQVFYLRRFFKAKKLI 218
>sp|Q90515|TMEDA_TAKRU Transmembrane emp24 domain-containing protein 10
OS=Takifugu rubripes GN=tmed10 PE=3 SV=1
Length = 213
Score = 101 bits (251), Expect = 7e-021
Identities = 57/210 (27%), Positives = 113/210 (53%), Gaps = 7/210 (3%)
Frame = +3
Query: 75 TFLLTLAIISGVSQSLHFELRSGRTKCISEDIKSNSMTVGKYTV---VKPDEAHPSPPSH 245
T LL L ++ + S+ F L KC+ E+I + + G+Y + V +
Sbjct: 5 TALLFLPVLIESAFSISFFLPVNTRKCLREEIHKDVLVTGEYEISEQVVTVHTSSTVVGD 64
Query: 246 KISIRVTSSYGNTFHHAEDVDSGQFAFTAVEAGDYMACFTA--NGHKPEVTLSIDFDWRT 419
++T S +T + ED G+FAFT + + CF + G P+ +++D +
Sbjct: 65 GSIFKITDSSSHTLYSKEDATKGKFAFTTEDYDMFEVCFESKCTGRVPDQLVNLDM--KH 122
Query: 420 GIHSKSWSSVAKKSQVEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAW 599
G+ +K++ +AK +++ +E E+++L + +I ++ Y++ REEEM++ N +TN+++ +
Sbjct: 123 GVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLY 182
Query: 600 LSFLSLFVCLGVAGMQFMHLKTFLEKKKVI 689
S S+F +G+A Q +L+ F + KK+I
Sbjct: 183 FSIFSMFCLIGLATWQVFYLRRFFKAKKLI 212
>sp|B4NIY1|TMEDA_DROWI Transmembrane emp24 domain-containing protein bai
OS=Drosophila willistoni GN=bai PE=3 SV=1
Length = 206
Score = 98 bits (242), Expect = 7e-020
Identities = 57/207 (27%), Positives = 106/207 (51%), Gaps = 11/207 (5%)
Frame = +3
Query: 81 LLTLAIISGV--SQSLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKIS 254
L TLAI + QS+ F L KC+ EDI++N M +G+Y V P I
Sbjct: 6 LATLAIFGCIWPGQSVMFHLTPNTQKCLKEDIQANQMVMGEYEV-------SDVPGQVID 58
Query: 255 IRVTSSYGNTFHHAEDVDSGQFAFTAVEAGDYMACFTAN--GHKPEVTLSIDFDWRTGIH 428
V + G+ E + +F+F + Y CF + H+ + + + G+
Sbjct: 59 FIVRDTKGHILSQKEHITKAKFSFMSEVYDSYEICFISKVPPHQRGIAQQVALTTKKGVE 118
Query: 429 SKSWSSVAKKSQVEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSF 608
+K++ + + S+++ +E ++K+L + ++I + +R REEEM++ N TNS++ + S
Sbjct: 119 TKNYEGIGEASKLKPLEVDLKRLEDLSDSIVRDFVMMRKREEEMRDTNEKTNSRVLFFSI 178
Query: 609 LSLFVCLGVAGMQFMHLKTFLEKKKVI 689
S+ LG+A Q ++L+ + + KK+I
Sbjct: 179 FSMCCLLGLATWQVLYLRRYFKAKKLI 205
>sp|B3LVB0|TMEDA_DROAN Transmembrane emp24 domain-containing protein bai
OS=Drosophila ananassae GN=bai PE=3 SV=1
Length = 206
Score = 97 bits (239), Expect = 2e-019
Identities = 53/205 (25%), Positives = 105/205 (51%), Gaps = 9/205 (4%)
Frame = +3
Query: 81 LLTLAIISGVSQSLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKISIR 260
L TL + +++ F+L KC+ EDI++N + +G+Y V P I
Sbjct: 8 LCTLMAWAWTGEAVMFKLTPNTQKCLKEDIQANQLVIGEYEV-------SDVPGQVIDYI 60
Query: 261 VTSSYGNTFHHAEDVDSGQFAFTAVEAGDYMACFTAN--GHKPEVTLSIDFDWRTGIHSK 434
+ G+ E + G+F+F + Y CF + H+ + + + G+ +K
Sbjct: 61 ARDTKGHILSQQEHITKGKFSFMSEVYDAYEICFISKVPPHQRGIPQEVSLSTKKGVETK 120
Query: 435 SWSSVAKKSQVEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSFLS 614
S+ + + S+++ +E ++K+L + ++I + +R REEEM++ N TNS++ + S S
Sbjct: 121 SYEGIGEASKLKPLEVDLKRLEDLSDSIVRDFVLMRKREEEMRDTNEKTNSRVLFFSIFS 180
Query: 615 LFVCLGVAGMQFMHLKTFLEKKKVI 689
+ LG+A Q ++L+ + + KK+I
Sbjct: 181 MCCLLGLATWQVLYLRRYFKAKKLI 205
>sp|B4JYU5|TMEDA_DROGR Transmembrane emp24 domain-containing protein bai
OS=Drosophila grimshawi GN=bai PE=3 SV=2
Length = 206
Score = 95 bits (235), Expect = 5e-019
Identities = 55/208 (26%), Positives = 107/208 (51%), Gaps = 12/208 (5%)
Frame = +3
Query: 81 LLTLAIISGVSQSLH---FELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKI 251
LL + +I G +H F L KC+ EDI++N + +G+Y V P I
Sbjct: 5 LLCILLIFGCLCRIHGVMFHLTPNTQKCLKEDIQANQLVMGEYEV-------SDVPGQII 57
Query: 252 SIRVTSSYGNTFHHAEDVDSGQFAFTAVEAGDYMACFTAN--GHKPEVTLSIDFDWRTGI 425
+ G+ E + G+F+FT+ Y CF + H+ ++ + + G+
Sbjct: 58 DYIARDTKGHILSQKEHITKGKFSFTSEVFDAYEICFISKVPPHQRGISQEVSLVTKKGV 117
Query: 426 HSKSWSSVAKKSQVEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLS 605
+K++ + + S+++ +E ++K+L + ++I + +R REEEM++ N TNS++ + S
Sbjct: 118 ETKNYEGIGEASKLKPLEVDLKRLEDLSDSIVRDFAVMRKREEEMRDTNEKTNSRVLFFS 177
Query: 606 FLSLFVCLGVAGMQFMHLKTFLEKKKVI 689
S+ LG+A Q ++L+ + + KK+I
Sbjct: 178 IFSMCCLLGLATWQVLYLRRYFKAKKLI 205
>sp|A0AQ71|TMEDA_DROSI Transmembrane emp24 domain-containing protein bai
OS=Drosophila simulans GN=bai PE=3 SV=1
Length = 206
Score = 94 bits (232), Expect = 1e-018
Identities = 52/195 (26%), Positives = 101/195 (51%), Gaps = 9/195 (4%)
Frame = +3
Query: 111 SQSLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKISIRVTSSYGNTFH 290
S ++ F+L KC+ EDI++N + +G+Y V P I + G+
Sbjct: 18 SHAVMFKLSPNTQKCLKEDIQANQLVMGEYEV-------SDVPGQIIDYIARDTKGHILS 70
Query: 291 HAEDVDSGQFAFTAVEAGDYMACFTAN--GHKPEVTLSIDFDWRTGIHSKSWSSVAKKSQ 464
E + G+F+F + Y CF + H+ V + + G+ +KS+ + + S+
Sbjct: 71 QKEHITKGKFSFMSEVYETYEICFISKVPAHQRGVVQEVSLLTKKGVETKSYEGIGEASK 130
Query: 465 VEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSFLSLFVCLGVAGM 644
++ +E ++K+L + ++I + +R REEEM++ N TNS++ + S S+ LG+A
Sbjct: 131 LKPLEVDLKRLEDLSDSIVRDFVLMRKREEEMRDTNEKTNSRVLFFSIFSMCCLLGLATW 190
Query: 645 QFMHLKTFLEKKKVI 689
Q ++L+ + + KK+I
Sbjct: 191 QVLYLRRYFKAKKLI 205
>sp|B3P6T8|TMEDA_DROER Transmembrane emp24 domain-containing protein bai
OS=Drosophila erecta GN=bai PE=3 SV=1
Length = 206
Score = 94 bits (231), Expect = 1e-018
Identities = 51/195 (26%), Positives = 101/195 (51%), Gaps = 9/195 (4%)
Frame = +3
Query: 111 SQSLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKISIRVTSSYGNTFH 290
S ++ F+L KC+ EDI++N + +G+Y V P I + G+
Sbjct: 18 SHAVMFKLSPNTQKCLKEDIQANQLVMGEYEV-------SDVPGQIIDYIARDTKGHILS 70
Query: 291 HAEDVDSGQFAFTAVEAGDYMACFTAN--GHKPEVTLSIDFDWRTGIHSKSWSSVAKKSQ 464
E + G+F+F + Y CF + H+ + + + G+ +KS+ + + S+
Sbjct: 71 QKEHITKGKFSFMSEVYDAYEICFISKVPAHQRGIVQEVSLLTKKGVETKSYEGIGEASK 130
Query: 465 VEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSFLSLFVCLGVAGM 644
++ +E ++K+L + ++I + +R REEEM++ N TNS++ + S S+ LG+A
Sbjct: 131 LKPLEVDLKRLEDLSDSIVRDFVLMRKREEEMRDTNEKTNSRVLFFSIFSMCCLLGLATW 190
Query: 645 QFMHLKTFLEKKKVI 689
Q ++L+ + + KK+I
Sbjct: 191 QVLYLRRYFKAKKLI 205
>sp|B4PUZ3|TMEDA_DROYA Transmembrane emp24 domain-containing protein bai
OS=Drosophila yakuba GN=bai PE=3 SV=1
Length = 206
Score = 94 bits (231), Expect = 1e-018
Identities = 51/195 (26%), Positives = 101/195 (51%), Gaps = 9/195 (4%)
Frame = +3
Query: 111 SQSLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKISIRVTSSYGNTFH 290
S ++ F+L KC+ EDI++N + +G+Y V P I + G+
Sbjct: 18 SHAVMFKLSPNTQKCLKEDIQANQLVMGEYEV-------SDVPGQIIDYIARDTKGHILS 70
Query: 291 HAEDVDSGQFAFTAVEAGDYMACFTAN--GHKPEVTLSIDFDWRTGIHSKSWSSVAKKSQ 464
E + G+F+F + Y CF + H+ + + + G+ +KS+ + + S+
Sbjct: 71 QKEHITKGKFSFMSEVYDAYEICFISKVPAHQRGIVQEVSLLTKKGVETKSYEGIGEASK 130
Query: 465 VEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSFLSLFVCLGVAGM 644
++ +E ++K+L + ++I + +R REEEM++ N TNS++ + S S+ LG+A
Sbjct: 131 LKPLEVDLKRLEDLSDSIVRDFVLMRKREEEMRDTNEKTNSRVLFFSIFSMCCLLGLATW 190
Query: 645 QFMHLKTFLEKKKVI 689
Q ++L+ + + KK+I
Sbjct: 191 QVLYLRRYFKAKKLI 205
>sp|B4K4G5|TMEDA_DROMO Transmembrane emp24 domain-containing protein bai
OS=Drosophila mojavensis GN=bai PE=3 SV=1
Length = 206
Score = 93 bits (229), Expect = 2e-018
Identities = 55/207 (26%), Positives = 104/207 (50%), Gaps = 12/207 (5%)
Frame = +3
Query: 84 LTLAIISGVSQSLH---FELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKIS 254
L + I G LH F L KC+ EDI++N + +G+Y V P I
Sbjct: 6 LAILTILGCIWPLHSVMFHLPPNTQKCLKEDIQANQLVMGEYEV-------SDVPGQVID 58
Query: 255 IRVTSSYGNTFHHAEDVDSGQFAFTAVEAGDYMACFTAN--GHKPEVTLSIDFDWRTGIH 428
+ G+ E + G+F+F + Y CF + H+ ++ + + G+
Sbjct: 59 YIARDTKGHILSQKEHITKGKFSFMSEVYDAYEICFISKVPPHQRGISQEVSLVTKKGVE 118
Query: 429 SKSWSSVAKKSQVEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSF 608
+KS+ + + S+++ +E ++K+L + ++I + +R REEEM++ N TNS++ + S
Sbjct: 119 TKSYEGIGEASKLKPLEVDLKRLEDLSDSIVRDFALMRKREEEMRDTNEKTNSRVLFFSI 178
Query: 609 LSLFVCLGVAGMQFMHLKTFLEKKKVI 689
S+ LG+A Q ++L+ + + KK+I
Sbjct: 179 FSMCCLLGLATWQVLYLRRYFKAKKLI 205
>sp|Q8SXY6|TMEDA_DROME Transmembrane emp24 domain-containing protein bai
OS=Drosophila melanogaster GN=bai PE=2 SV=1
Length = 206
Score = 92 bits (228), Expect = 3e-018
Identities = 51/195 (26%), Positives = 101/195 (51%), Gaps = 9/195 (4%)
Frame = +3
Query: 111 SQSLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKISIRVTSSYGNTFH 290
S ++ F+L KC+ EDI++N + +G++ V P I + G+
Sbjct: 18 SHAVMFKLSPNTQKCLKEDIQANQLVMGEFEV-------SDVPGQIIDYIARDTKGHILS 70
Query: 291 HAEDVDSGQFAFTAVEAGDYMACFTAN--GHKPEVTLSIDFDWRTGIHSKSWSSVAKKSQ 464
E + G+F+F + Y CF + H+ V + + G+ +KS+ + + S+
Sbjct: 71 QKEHITKGKFSFMSEVYDTYEICFISKVPAHQRGVIQEVSLLTKKGVETKSYEGIGEASK 130
Query: 465 VEVMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSFLSLFVCLGVAGM 644
++ +E ++K+L + ++I + +R REEEM++ N TNS++ + S S+ LG+A
Sbjct: 131 LKPLEVDLKRLEDLSDSIVRDFVLMRKREEEMRDTNEKTNSRVLFFSIFSMCCLLGLATW 190
Query: 645 QFMHLKTFLEKKKVI 689
Q ++L+ + + KK+I
Sbjct: 191 QVLYLRRYFKAKKLI 205
>sp|B4GE47|TMEDA_DROPE Transmembrane emp24 domain-containing protein bai
OS=Drosophila persimilis GN=bai PE=3 SV=1
Length = 206
Score = 92 bits (228), Expect = 3e-018
Identities = 51/193 (26%), Positives = 99/193 (51%), Gaps = 9/193 (4%)
Frame = +3
Query: 117 SLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKISIRVTSSYGNTFHHA 296
S+ F L KC+ EDI++N + +G+Y V P I + G+
Sbjct: 20 SVMFNLAPNTQKCLKEDIQANQLVMGEYEV-------SDVPGQIIDYVARDTKGHILSQK 72
Query: 297 EDVDSGQFAFTAVEAGDYMACFTAN--GHKPEVTLSIDFDWRTGIHSKSWSSVAKKSQVE 470
E + G+F+F + Y CF + H+ + + + G+ +KS+ + + S+++
Sbjct: 73 EHITKGKFSFMSEVYDAYEICFISKVPPHQRGIPQEVSLVTKKGVETKSYEGIGEASKLK 132
Query: 471 VMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSFLSLFVCLGVAGMQF 650
+E ++K+L + ++I + +R REEEM++ N TNS++ + S S+ LG+A Q
Sbjct: 133 PLEVDLKRLEDLSDSIVRDFILMRKREEEMRDTNEKTNSRVLFFSIFSMCCLLGLATWQV 192
Query: 651 MHLKTFLEKKKVI 689
++L+ + + KK+I
Sbjct: 193 LYLRRYFKAKKLI 205
>sp|B4MGF8|TMEDA_DROVI Transmembrane emp24 domain-containing protein bai
OS=Drosophila virilis GN=bai PE=3 SV=1
Length = 206
Score = 92 bits (228), Expect = 3e-018
Identities = 51/193 (26%), Positives = 100/193 (51%), Gaps = 9/193 (4%)
Frame = +3
Query: 117 SLHFELRSGRTKCISEDIKSNSMTVGKYTVVKPDEAHPSPPSHKISIRVTSSYGNTFHHA 296
S+ F L KC+ EDI++N + +G+Y V P I + G+
Sbjct: 20 SVMFHLTPNTQKCLKEDIQANQLVMGEYEV-------SDVPGQIIDYIARDTKGHILSQK 72
Query: 297 EDVDSGQFAFTAVEAGDYMACFTAN--GHKPEVTLSIDFDWRTGIHSKSWSSVAKKSQVE 470
E + G+F+F + Y CF + H+ ++ + + G+ +KS+ + + S+++
Sbjct: 73 EHITKGKFSFMSEVYDAYEICFISKVPPHQRGISQEVSLVTKKGVETKSYEGIGEASKLK 132
Query: 471 VMEFEVKQLIETVNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSFLSLFVCLGVAGMQF 650
+E ++K+L + ++I + +R REEEM++ N TNS++ + S S+ LG+A Q
Sbjct: 133 PLEVDLKRLEDLSDSIVRDFALMRKREEEMRDTNEKTNSRVLFFSIFSMCCLLGLATWQV 192
Query: 651 MHLKTFLEKKKVI 689
++L+ + + KK+I
Sbjct: 193 LYLRRYFKAKKLI 205
>sp|Q9D2R4|TMD11_MOUSE Transmembrane emp24 domain-containing protein 11 OS=Mus
musculus GN=Tmed11 PE=2 SV=1
Length = 215
Score = 70 bits (170), Expect = 2e-011
Identities = 49/181 (27%), Positives = 82/181 (45%), Gaps = 5/181 (2%)
Frame = +3
Query: 159 SEDIKSNSMTVGKYTVVKPDEAHPSPPSHKISIRVTSSYGNTFHHAEDVDSGQFAFTAVE 338
S+ + + + V ++ +V+ D S P + + VT+ G F FT+
Sbjct: 36 SDTLITGTFKVQQWDIVRHDFLE-SAPGLGMFVTVTTYNDEVLLSKLYGAQGTFYFTSHS 94
Query: 339 AGDYMACFTANGHK----PEVTLSIDFDWRTGIHSKSWSSVAKKSQVEVMEFEVKQLIET 506
+G+++ C +N + L I D R G H + V K +V + F+++ LIE
Sbjct: 95 SGEHIICLESNSTQFVSFGGSKLRIHLDIRVGEHDLDAAIVQAKDKVNEVTFKLQHLIEQ 154
Query: 507 VNTIHDEMFYLRDREEEMQNLNRATNSKMAWLSFLSLFVCLGVAGMQFMHLKTFLEKKKV 686
V I E Y RDREE + + TN + W +F + + + V Q HLK F KK+
Sbjct: 155 VEQILKEQDYQRDREENFRITSEDTNRNVLWWAFAQILIFISVGIFQMKHLKDFFIAKKL 214
Query: 687 I 689
+
Sbjct: 215 V 215
>sp|Q4WQL0|TMEDA_ASPFU Endoplasmic reticulum vesicle protein 25 OS=Aspergillus
fumigatus GN=erv25 PE=3 SV=1
Length = 266
Score = 67 bits (162), Expect = 1e-010
Identities = 52/216 (24%), Positives = 105/216 (48%), Gaps = 24/216 (11%)
Frame = +3
Query: 60 SENTWTFLLTLAIISGVSQSLHFELRSG---RTKCISEDIKSNSMTVGKYTVVKPDEAHP 230
S T LL L ++ +S +L F+L + +CI N + + VV +
Sbjct: 8 STRTLLGLLFLLLVQ-LSSALKFDLHASSGHNERCI-----RNFVFKDQLVVVTAIVSGQ 61
Query: 231 SPPSHKISIRVTSSYGNTFHHAEDV-DSGQFAFTAVEAGDYMACF---------TANGHK 380
+++ + + GN +D+ + AFT+V + CF AN +K
Sbjct: 62 RGDGQVVNMHIKDALGNDHGRPKDIAGETRQAFTSVADTAFDVCFENKLVSHHGVANPYK 121
Query: 381 PEVTLSIDFDWRTGIHSKSWSSVAKKSQVEVMEFEVKQLIETVNTIHDEMFYLRDREEEM 560
S++ D G ++ WSSV +++ +E +++++ E V I +EM YLR RE+++
Sbjct: 122 -----SVELDVEIGADARDWSSVQAAEKLKPVETDLRRIEEMVAEIVNEMEYLRAREQKL 176
Query: 561 QNLNRATNSKMAWLSFLSLFVCLGVAGMQFMHLKTF 668
++ N +TN ++ W +F ++ + +G+ Q ++L+ +
Sbjct: 177 RDTNESTNERVKWFAFGTMGMLVGLGVWQVVYLRAY 212
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,545,185,555
Number of Sequences: 518415
Number of Extensions: 16545185555
Number of Successful Extensions: 102511304
Number of sequences better than 0.0: 0
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