BLASTX 7.6.2
Query= UN03925 /QuerySize=1695
(1694 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P55862|MCM5A_XENLA DNA replication licensing factor mcm5-A OS... 515 6e-145
sp|Q561P5|MCM5_XENTR DNA replication licensing factor mcm5 OS=Xe... 512 3e-144
sp|Q6PCI7|MCM5B_XENLA DNA replication licensing factor mcm5-B OS... 508 6e-143
sp|P49718|MCM5_MOUSE DNA replication licensing factor MCM5 OS=Mu... 502 4e-141
sp|P41389|MCM5_SCHPO DNA replication licensing factor mcm5 OS=Sc... 502 6e-141
sp|Q0V8B7|MCM5_BOVIN DNA replication licensing factor MCM5 OS=Bo... 500 1e-140
sp|P33992|MCM5_HUMAN DNA replication licensing factor MCM5 OS=Ho... 500 2e-140
sp|P29496|MCM5_YEAST Minichromosome maintenance protein 5 OS=Sac... 497 2e-139
sp|Q54CP4|MCM5_DICDI DNA replication licensing factor mcm5 OS=Di... 385 8e-106
sp|Q21902|MCM5_CAEEL DNA replication licensing factor mcm-5 OS=C... 373 2e-102
sp|P40377|MCM2_SCHPO DNA replication licensing factor mcm2 OS=Sc... 313 3e-084
sp|P43299|PROL_ARATH Protein PROLIFERA OS=Arabidopsis thaliana G... 306 3e-082
sp|O75001|MCM7_SCHPO DNA replication licensing factor mcm7 OS=Sc... 292 9e-078
sp|P49739|MCM3M_XENLA Maternal DNA replication licensing factor ... 277 2e-073
sp|Q86B14|MCM6_DICDI DNA replication licensing factor mcm6 OS=Di... 272 7e-072
sp|P53091|MCM6_YEAST DNA replication licensing factor MCM6 OS=Sa... 267 2e-070
sp|Q14566|MCM6_HUMAN DNA replication licensing factor MCM6 OS=Ho... 262 6e-069
sp|Q62724|MCM6_RAT DNA replication licensing factor MCM6 (Fragme... 262 6e-069
sp|Q498J7|MC6ZA_XENLA Zygotic DNA replication licensing factor m... 262 8e-069
sp|Q5FWY4|MCM6M_XENLA Maternal DNA replication licensing factor ... 262 8e-069
>sp|P55862|MCM5A_XENLA DNA replication licensing factor mcm5-A OS=Xenopus laevis
GN=mcm5-a PE=1 SV=2
Length = 735
Score = 515 bits (1324), Expect = 6e-145
Identities = 270/498 (54%), Positives = 351/498 (70%), Gaps = 6/498 (1%)
Frame = -3
Query: 1677 VPTGELPRNMLLSVDRHLVQLIVPGTILTVMGIYSIFQASSSSNSHKG--AVAIRQPYVR 1504
VP GELPR+M L DR+L +VPG +T+MGIYSI ++ +S + V IR Y+R
Sbjct: 237 VPHGELPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIRKSGKTSTKGRDRVGVGIRSSYIR 296
Query: 1503 VVGLEDTNEASSRGPAN-FTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAVAC 1327
VVG++ E + R A TP EEEEF++ AA D+Y + IAPSI+G D+K+A+AC
Sbjct: 297 VVGIQVDTEGTGRSAAGAITPQEEEEFRRLAAKPDIYETVAKSIAPSIYGSSDIKKAIAC 356
Query: 1326 LLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLT 1147
LLFGGSRK LPDG+ RGD+N+L+LGDP TAKSQ LKFVE+ +PI VYTSGKGSSAAGLT
Sbjct: 357 LLFGGSRKRLPDGLTRRGDVNLLMLGDPGTAKSQLLKFVERCSPIGVYTSGKGSSAAGLT 416
Query: 1146 ASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGIT 967
ASV+RD +R F +EGGAMVLADGGVVCIDEFDKMR +DRVAIHEAMEQQTISIAKAGIT
Sbjct: 417 ASVMRDPVSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGIT 476
Query: 966 TVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEIAS 787
T LNSR SVLAAAN GR+DD K ++NID TILSRFD+IFIVKD N +D +A
Sbjct: 477 TTLNSRCSVLAAANSVYGRWDDTK-GEENIDFMPTILSRFDMIFIVKDEHNEQRDMTLAK 535
Query: 786 HIIRVHASADKVTDENTDSKEDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTIREDMK 607
H++ VH SA + + N LK+YI YCR++C PRL+ AA KL+ Y+ +R +
Sbjct: 536 HVMNVHLSARTQSSSVEGEVDLNTLKKYIAYCRAKCGPRLSAEAAEKLKNRYILMRSGAR 595
Query: 606 RSAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHDATEDDVEKAYKLFKTATMDAAKS 427
ET + + IPITVRQLEAIVR+SESL KM+L ATE DVE+A +LF+ +T+DAA S
Sbjct: 596 EHERETEKRSSIPITVRQLEAIVRISESLGKMKLQPFATETDVEEALRLFQVSTLDAAMS 655
Query: 426 GINQQIN--ITSEMAKEIKQAETQIKRRMGIGARLSERRLIEDLARMGMNESMVRRALLI 253
G + T E + + + E Q+K+R IG+++SE +I+D + E + + L +
Sbjct: 656 GSLSGVEGFTTQEDQEMLSRIEKQMKKRFAIGSQVSEHSIIQDFLKQKYPEHAIHKVLSL 715
Query: 252 MHQRGEVEYQRERRSIVR 199
M +RGE++++ +R+ + R
Sbjct: 716 MMRRGEIQHRLQRKVLYR 733
>sp|Q561P5|MCM5_XENTR DNA replication licensing factor mcm5 OS=Xenopus
tropicalis GN=mcm5 PE=2 SV=1
Length = 735
Score = 512 bits (1318), Expect = 3e-144
Identities = 269/498 (54%), Positives = 351/498 (70%), Gaps = 6/498 (1%)
Frame = -3
Query: 1677 VPTGELPRNMLLSVDRHLVQLIVPGTILTVMGIYSIFQASSSSNSHKG--AVAIRQPYVR 1504
VP GELPR+M L DR+L +VPG +T+MGIYSI ++ +S + V IR Y+R
Sbjct: 237 VPHGELPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIRKSGKTSTKGRDRVGVGIRSSYIR 296
Query: 1503 VVGLEDTNEASSRGPAN-FTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAVAC 1327
VVG++ E + R A TP EEEEF++ +A D+Y + IAPSI+G D+K+A+AC
Sbjct: 297 VVGIQVDTEGTGRSAAGAITPQEEEEFRRLSAKPDIYETVAKSIAPSIYGSSDIKKAIAC 356
Query: 1326 LLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLT 1147
LLFGGSRK LPDG+ RGD+N+L+LGDP TAKSQ LKFVE+ +PI VYTSGKGSSAAGLT
Sbjct: 357 LLFGGSRKRLPDGLTRRGDVNLLMLGDPGTAKSQLLKFVERCSPIGVYTSGKGSSAAGLT 416
Query: 1146 ASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGIT 967
ASV+RD +R F +EGGAMVLADGGVVCIDEFDKMR +DRVAIHEAMEQQTISIAKAGIT
Sbjct: 417 ASVMRDPVSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGIT 476
Query: 966 TVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEIAS 787
T LNSR SVLAAAN GR+DD K ++NID TILSRFD+IFIVKD N +D +A
Sbjct: 477 TTLNSRCSVLAAANSVYGRWDDTK-GEENIDFMPTILSRFDMIFIVKDEHNEQRDMTLAK 535
Query: 786 HIIRVHASADKVTDENTDSKEDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTIREDMK 607
H++ VH SA + + N LK+YI YCR++C PRL+ +A KL+ Y+ +R +
Sbjct: 536 HVMNVHLSARTQSSSVEGEIDLNTLKKYIAYCRAKCGPRLSAESAEKLKNRYILMRSGAR 595
Query: 606 RSAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHDATEDDVEKAYKLFKTATMDAAKS 427
ET + + IPITVRQLEAIVR+SESL KM+L ATE DVE+A +LF+ +T+DAA S
Sbjct: 596 DHERETEKRSSIPITVRQLEAIVRISESLGKMKLQPFATETDVEEALRLFQVSTLDAAMS 655
Query: 426 GINQQIN--ITSEMAKEIKQAETQIKRRMGIGARLSERRLIEDLARMGMNESMVRRALLI 253
G + T E + + + E Q+KRR IG+++SE +I+D + E + + L +
Sbjct: 656 GSLSGVEGFTTQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIQDFLKQKYPEHAIHKVLHL 715
Query: 252 MHQRGEVEYQRERRSIVR 199
M +RGE++++ +R+ + R
Sbjct: 716 MMRRGEIQHRLQRKVLYR 733
>sp|Q6PCI7|MCM5B_XENLA DNA replication licensing factor mcm5-B OS=Xenopus laevis
GN=mcm5-b PE=2 SV=1
Length = 735
Score = 508 bits (1307), Expect = 6e-143
Identities = 267/498 (53%), Positives = 348/498 (69%), Gaps = 6/498 (1%)
Frame = -3
Query: 1677 VPTGELPRNMLLSVDRHLVQLIVPGTILTVMGIYSIFQASSSSNSHKG--AVAIRQPYVR 1504
VP GELPR+M L DR+L +VPG +T+MGIYSI ++ +S + V IR Y+R
Sbjct: 237 VPHGELPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIQKSGKTSTKGRDRVGVGIRSSYIR 296
Query: 1503 VVGLEDTNEASSRGPA-NFTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAVAC 1327
VVG++ E + R A TP EEEEF++ A D+Y + IAPSI+G D+K+A+AC
Sbjct: 297 VVGIQVDTEGTGRSAAGTITPQEEEEFRRLAVKPDIYETVAKSIAPSIYGSTDIKKAIAC 356
Query: 1326 LLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLT 1147
LLFGGSRK LPDG+ RGD+N+L+LGDP TAKSQ LKFVE+ +PI VYTSGKGSSAAGLT
Sbjct: 357 LLFGGSRKRLPDGLTRRGDVNLLMLGDPGTAKSQLLKFVERCSPIGVYTSGKGSSAAGLT 416
Query: 1146 ASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGIT 967
ASV+RD +R F +EGGAMVLADGGVVCIDEFDKMR +DRVAIHEAMEQQTISIAKAGIT
Sbjct: 417 ASVMRDPVSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGIT 476
Query: 966 TVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEIAS 787
T LNSR SVLAAAN GR+DD K ++NID TILSRFD+IFIVKD N +D +A
Sbjct: 477 TTLNSRCSVLAAANSVYGRWDDTK-GEENIDFMPTILSRFDMIFIVKDEHNEQRDMTLAK 535
Query: 786 HIIRVHASADKVTDENTDSKEDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTIREDMK 607
H++ VH SA + + N LK++I YCR++C PRL+ AA KL+ Y+ +R +
Sbjct: 536 HVMNVHLSARTQSSSVEGEVDLNTLKKFIAYCRAKCGPRLSAEAAEKLKNRYILMRSGAR 595
Query: 606 RSAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHDATEDDVEKAYKLFKTATMDAAKS 427
ET + + IPITVRQLEA+VR+SESL KM+L TE DVE+A +LF+ +T+DAA S
Sbjct: 596 DHERETEKRSSIPITVRQLEAVVRISESLGKMKLQPFVTETDVEEALRLFQVSTLDAAMS 655
Query: 426 GINQQIN--ITSEMAKEIKQAETQIKRRMGIGARLSERRLIEDLARMGMNESMVRRALLI 253
G + T E + + + E Q+KRR IG+++SE +I+D + E + + L +
Sbjct: 656 GSLSGVEGFSTQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIQDFLKQKYPEHAIHKVLNL 715
Query: 252 MHQRGEVEYQRERRSIVR 199
M +RGE+ ++ +R+ + R
Sbjct: 716 MMRRGEIHHRLQRKVLYR 733
>sp|P49718|MCM5_MOUSE DNA replication licensing factor MCM5 OS=Mus musculus
GN=Mcm5 PE=2 SV=1
Length = 733
Score = 502 bits (1291), Expect = 4e-141
Identities = 267/498 (53%), Positives = 354/498 (71%), Gaps = 6/498 (1%)
Frame = -3
Query: 1677 VPTGELPRNMLLSVDRHLVQLIVPGTILTVMGIYSI--FQASSSSNSHKGAVAIRQPYVR 1504
VP GE+PR+M L DR+L +VPG +T+MGIYSI F + S + V IR Y+R
Sbjct: 235 VPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLNPSKGRDRVGVGIRSSYIR 294
Query: 1503 VVGLEDTNEASSRGPA-NFTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAVAC 1327
V+G++ + S R A + +P EEEEF++ AA ++Y I I+PSIFG D+K+A+AC
Sbjct: 295 VLGIQVDTDGSGRSFAGSVSPQEEEEFRRLAALPNIYELISKSISPSIFGGMDMKKAIAC 354
Query: 1326 LLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLT 1147
LLFGGSRK LPDG+ RGDIN+L+LGDP TAKSQ LKFVEK +PI VYTSGKGSSAAGLT
Sbjct: 355 LLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLT 414
Query: 1146 ASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGIT 967
ASVIRD S+R F +EGGAMVLADGGVVCIDEFDKMR +DRVAIHEAMEQQTISIAKAGIT
Sbjct: 415 ASVIRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGIT 474
Query: 966 TVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEIAS 787
T LNSR SVLAAAN GR+D+ K +DNID TILSRFD+IFIVKD N ++D +A
Sbjct: 475 TTLNSRCSVLAAANSVFGRWDETK-GEDNIDFMPTILSRFDMIFIVKDEHNEERDMMLAK 533
Query: 786 HIIRVHASADKVTDENTDSKEDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTIREDMK 607
H++ +H SA T + +K++I YCR+RC PRL+ AA KL+ Y+ +R +
Sbjct: 534 HVMTLHVSALTQTQAVEGEIDLAKMKKFIAYCRARCGPRLSAEAAEKLKNRYIIMRSGAR 593
Query: 606 RSAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHDATEDDVEKAYKLFKTATMDAAKS 427
+ ++ + IPITVRQLEAIVR++E+L+KM+L ATE DVE+A +LF+ +T+DAA S
Sbjct: 594 QHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALS 653
Query: 426 GINQQIN--ITSEMAKEIKQAETQIKRRMGIGARLSERRLIEDLARMGMNESMVRRALLI 253
G + T E + + + E Q+KRR IG+++SE +++D + E +R+ L +
Sbjct: 654 GNLSGVEGFTTQEDQEMLSRIEKQLKRRFAIGSQVSEHSIVQDFTKQKYPEHAIRKVLQL 713
Query: 252 MHQRGEVEYQRERRSIVR 199
M +RGE++++ +R+ + R
Sbjct: 714 MLRRGEIQHRMQRKVLYR 731
>sp|P41389|MCM5_SCHPO DNA replication licensing factor mcm5
OS=Schizosaccharomyces pombe GN=mcm5 PE=1 SV=2
Length = 720
Score = 502 bits (1290), Expect = 6e-141
Identities = 271/499 (54%), Positives = 357/499 (71%), Gaps = 13/499 (2%)
Frame = -3
Query: 1692 ENPEDVPTGELPRNMLLSVDRHLVQLIVPGTILTVMGIYSIFQASSSSNSHKGAVAIRQP 1513
E P+ VP GELPR++LL+ DR+L I PGT + GI+SIFQ S S GAVAIR P
Sbjct: 227 EAPDMVPVGELPRHILLNADRYLTNQITPGTRCVITGIFSIFQNKSVKAS--GAVAIRNP 284
Query: 1512 YVRVVGLE-DTNEASSRGPANFTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRA 1336
Y+RVVG++ D+N+ S P F+ +EEEEF + + + ++Y I I+P+I+G+ D+K+A
Sbjct: 285 YIRVVGIQMDSNDGSKSTPL-FSEEEEEEFLEISRTPNLYDIISNSISPAIYGNVDIKKA 343
Query: 1335 VACLLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAA 1156
+ACLLF GS+K LPDG++LRGDINVLLLGDP TAKSQFLKFVE+ APIAVYTSGKGSSAA
Sbjct: 344 IACLLFSGSKKILPDGMRLRGDINVLLLGDPGTAKSQFLKFVERLAPIAVYTSGKGSSAA 403
Query: 1155 GLTASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKA 976
GLTAS+ RDS TREFYLEGGAMVLADGG+VCIDEFDKMR EDRVAIHEAMEQQTISIAKA
Sbjct: 404 GLTASIQRDSVTREFYLEGGAMVLADGGIVCIDEFDKMRDEDRVAIHEAMEQQTISIAKA 463
Query: 975 GITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKE 796
GITT+LNSRTSVLAAANP GRYDD+KT +NID Q+TILSRFD+IFIVKD + +D+
Sbjct: 464 GITTILNSRTSVLAAANPIFGRYDDMKTPGENIDFQSTILSRFDMIFIVKDEHDETKDRN 523
Query: 795 IASHIIRVHASADKVTDENTDSK-EDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTIR 619
IA H+I +H + + ++ + + +RYI YCR +C P L AA KL +V IR
Sbjct: 524 IARHVINLHTNLQESSETLAIGEIPFDKFRRYINYCRHKCAPNLDAEAAEKLSSQFVAIR 583
Query: 618 EDMKRSAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHDATEDDVEKAYKLFKTATMD 439
+ + +S ++ + IPITVRQLEAI+R++ESLAKM LS A+E +A +LF T+T+
Sbjct: 584 KLVHQSEQDSNSRSTIPITVRQLEAIIRITESLAKMSLSPIASEAHATEAIRLFLTSTLA 643
Query: 438 AAKSGINQQINITSEMAKEIKQAETQIKRRMGIGARLSERRLIEDLAR-MGMNESMVRRA 262
AA + E+ +E+K+ E +++R+ IG + S R LI + G ++ + A
Sbjct: 644 AATQS-------SPEVTEEVKKIEASLRKRLPIGFQASYRMLIREYVNGHGYSQHALEMA 696
Query: 261 LLIMHQRGEVEYQRERRSI 205
L I + ++ + +++
Sbjct: 697 LQIRSSKETIQLRNGGQTV 715
>sp|Q0V8B7|MCM5_BOVIN DNA replication licensing factor MCM5 OS=Bos taurus
GN=MCM5 PE=2 SV=1
Length = 734
Score = 500 bits (1287), Expect = 1e-140
Identities = 269/498 (54%), Positives = 354/498 (71%), Gaps = 6/498 (1%)
Frame = -3
Query: 1677 VPTGELPRNMLLSVDRHLVQLIVPGTILTVMGIYSI--FQASSSSNSHKGAVAIRQPYVR 1504
VP GE+PR+M L DR+L +VPG +T+MGIYSI F +S+ + V IR Y+R
Sbjct: 236 VPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTSNRGRDRVGVGIRSAYIR 295
Query: 1503 VVGLEDTNEASSRGPAN-FTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAVAC 1327
V+G++ + S R A TP EEEEF++ AA ++Y I IAPSIFG D+K+A+AC
Sbjct: 296 VLGIQVDTDGSGRTFAGAMTPQEEEEFRRLAALPNIYELISKSIAPSIFGGTDMKKAIAC 355
Query: 1326 LLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLT 1147
LLFGGSRK LPDG+ RGDIN+L+LGDP TAKSQ LKFVEK +PI VYTSGKGSSAAGLT
Sbjct: 356 LLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLT 415
Query: 1146 ASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGIT 967
ASV+RD S+R F +EGGAMVLADGGVVCIDEFDKMR +DRVAIHEAMEQQTISIAKAGIT
Sbjct: 416 ASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGIT 475
Query: 966 TVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEIAS 787
T LNSR SVLAAAN GR+D+ K +DNID TILSRFD+IFIVKD N ++D +A
Sbjct: 476 TTLNSRCSVLAAANSVFGRWDETK-GEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAK 534
Query: 786 HIIRVHASADKVTDENTDSKEDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTIREDMK 607
H+I +H SA + LK++I YCR++C PRL+ AA KL+ Y+ +R +
Sbjct: 535 HVITLHVSALTQAQAVEGEIDLAKLKKFIAYCRAKCGPRLSAEAAEKLKNRYIIMRSGAR 594
Query: 606 RSAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHDATEDDVEKAYKLFKTATMDAAKS 427
+ ++ + IPITVRQLEAIVR++E+L+KM+L ATE DVE+A +LF+ +T+DAA S
Sbjct: 595 QHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALS 654
Query: 426 GINQQI-NITSEMAKE-IKQAETQIKRRMGIGARLSERRLIEDLARMGMNESMVRRALLI 253
G + TS+ +E + + E Q+KRR IG+++SE +I+D + E + + L +
Sbjct: 655 GTLSGVEGFTSQEDQELLSRIEKQLKRRFAIGSQVSEHSIIQDFTKQKYPEHAIHKVLQL 714
Query: 252 MHQRGEVEYQRERRSIVR 199
M +RGE++++ +R+ + R
Sbjct: 715 MLRRGEIQHRMQRKVLYR 732
>sp|P33992|MCM5_HUMAN DNA replication licensing factor MCM5 OS=Homo sapiens
GN=MCM5 PE=1 SV=5
Length = 734
Score = 500 bits (1286), Expect = 2e-140
Identities = 270/498 (54%), Positives = 354/498 (71%), Gaps = 6/498 (1%)
Frame = -3
Query: 1677 VPTGELPRNMLLSVDRHLVQLIVPGTILTVMGIYSI--FQASSSSNSHKGAVAIRQPYVR 1504
VP GE+PR+M L DR+L +VPG +T+MGIYSI F ++S + V IR Y+R
Sbjct: 236 VPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIR 295
Query: 1503 VVGLEDTNEASSRGPAN-FTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAVAC 1327
V+G++ + S R A +P EEEEF++ AA +VY I IAPSIFG D+K+A+AC
Sbjct: 296 VLGIQVDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIAC 355
Query: 1326 LLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLT 1147
LLFGGSRK LPDG+ RGDIN+L+LGDP TAKSQ LKFVEK +PI VYTSGKGSSAAGLT
Sbjct: 356 LLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLT 415
Query: 1146 ASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGIT 967
ASV+RD S+R F +EGGAMVLADGGVVCIDEFDKMR +DRVAIHEAMEQQTISIAKAGIT
Sbjct: 416 ASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGIT 475
Query: 966 TVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEIAS 787
T LNSR SVLAAAN GR+D+ K +DNID TILSRFD+IFIVKD N ++D +A
Sbjct: 476 TTLNSRCSVLAAANSVFGRWDETK-GEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAK 534
Query: 786 HIIRVHASADKVTDENTDSKEDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTIREDMK 607
H+I +H SA T + LK++I YCR +C PRL+ AA KL+ Y+ +R +
Sbjct: 535 HVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGAR 594
Query: 606 RSAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHDATEDDVEKAYKLFKTATMDAAKS 427
+ ++ + IPITVRQLEAIVR++E+L+KM+L ATE DVE+A +LF+ +T+DAA S
Sbjct: 595 QHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALS 654
Query: 426 GINQQI-NITSEMAKE-IKQAETQIKRRMGIGARLSERRLIEDLARMGMNESMVRRALLI 253
G + TS+ +E + + E Q+KRR IG+++SE +I+D + E + + L +
Sbjct: 655 GTLSGVEGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQL 714
Query: 252 MHQRGEVEYQRERRSIVR 199
M +RGE++++ +R+ + R
Sbjct: 715 MLRRGEIQHRMQRKVLYR 732
>sp|P29496|MCM5_YEAST Minichromosome maintenance protein 5 OS=Saccharomyces
cerevisiae GN=MCM5 PE=1 SV=1
Length = 775
Score = 497 bits (1277), Expect = 2e-139
Identities = 270/507 (53%), Positives = 354/507 (69%), Gaps = 21/507 (4%)
Frame = -3
Query: 1665 ELPRNMLLSVDRHLVQLIVPGTILTVMGIYSIFQASSSSNSHK-------GAVAIRQPYV 1507
E+PRN+ ++ DR+L ++PGT +T++GIYSI+ + + + S + VAIR PY+
Sbjct: 269 EMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGAGSGRSGGGNGGSGVAIRTPYI 328
Query: 1506 RVVGLEDTNEASS--RGPANFTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAV 1333
+++G++ E SS FT +EEEEF + + + +Y + IAPSIFG+ D+K+A+
Sbjct: 329 KILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAI 388
Query: 1332 ACLLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAG 1153
CLL GGS+K LPDG++LRGDINVLLLGDP TAKSQ LKFVEK +PIAVYTSGKGSSAAG
Sbjct: 389 VCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAG 448
Query: 1152 LTASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAG 973
LTASV RD TREFYLEGGAMVLADGGVVCIDEFDKMR EDRVAIHEAMEQQTISIAKAG
Sbjct: 449 LTASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAG 508
Query: 972 ITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEI 793
ITTVLNSRTSVLAAANP GRYDDLK+ DNID QTTILSRFD+IFIVKD N ++D I
Sbjct: 509 ITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISI 568
Query: 792 ASHIIRVHA----SADKVTDENTDSKEDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVT 625
A+H+I +H + +EN +KRYI YCR +C PRL+ AA KL +VT
Sbjct: 569 ANHVINIHTGNANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVT 628
Query: 624 IREDMKRSAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHDATEDDVEKAYKLFKTAT 445
IR+ + + E+ E + IPIT+RQLEAI+R++ESLAK+ LS A E V++A +LF+ +T
Sbjct: 629 IRKQLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQAST 688
Query: 444 MDAAK----SGINQQINITSEMAKEIKQAETQIKRRMGIGARLSERRLIEDLA-RMGMNE 280
MDAA G+NQ + EI++ E ++KRR+ IG S + L + ++
Sbjct: 689 MDAASQDPIGGLNQ---ASGTSLSEIRRFEQELKRRLPIGWSTSYQTLRREFVDTHRFSQ 745
Query: 279 SMVRRALLIMHQRGEVEYQRERRSIVR 199
+ +AL + + ++ + + ++I R
Sbjct: 746 LALDKALYALEKHETIQLRHQGQNIYR 772
>sp|Q54CP4|MCM5_DICDI DNA replication licensing factor mcm5 OS=Dictyostelium
discoideum GN=mcm5 PE=3 SV=1
Length = 757
Score = 385 bits (987), Expect = 8e-106
Identities = 197/313 (62%), Positives = 244/313 (77%), Gaps = 5/313 (1%)
Frame = -3
Query: 1692 ENPEDVPTGELPRNMLLSVDRHLVQLIVPGTILTVMGIYSIFQASSSSNSHKGAVAIRQP 1513
E+PE +PTGE+PR+++LS+D+ L I PGT + V+G+ IF+ G IR
Sbjct: 225 ESPETIPTGEMPRHIILSLDKSLADKITPGTRIKVLGVLGIFEGGGKRREIAGG-TIRTN 283
Query: 1512 YVRVVGLEDTNEASSRGPANFTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAV 1333
Y+RV+G+ T++ + R +FTP EE+ FK F+ QD+ + I + IAPSI+GH D+KRA+
Sbjct: 284 YLRVLGI--TSDNAGRDSMHFTPSEEQSFKVFSRRQDLRNIIASSIAPSIYGHEDIKRAI 341
Query: 1332 ACLLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAG 1153
+C LFGGS K LPD ++LRGDIN+LLLGDP TAKSQ LKFVEK API+VYTSGKGSSAAG
Sbjct: 342 SCQLFGGSSKKLPDKMRLRGDINLLLLGDPGTAKSQLLKFVEKVAPISVYTSGKGSSAAG 401
Query: 1152 LTASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAG 973
LTASVIR+ ST E+YLEGGAMV+ADGGVVCIDEFDKM +DRVAIHEAMEQQTISIAKAG
Sbjct: 402 LTASVIREPSTGEYYLEGGAMVVADGGVVCIDEFDKMNVDDRVAIHEAMEQQTISIAKAG 461
Query: 972 ITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEI 793
ITT+LNSRTSVLAAANP GRY+D A DNI+ Q+TILSRFDLIFIVKD +N +D I
Sbjct: 462 ITTILNSRTSVLAAANPVYGRYND--AADDNINFQSTILSRFDLIFIVKDPKNEKRDFII 519
Query: 792 ASHIIRVHASADK 754
+ H+I +H + +
Sbjct: 520 SKHVINIHEKSSR 532
>sp|Q21902|MCM5_CAEEL DNA replication licensing factor mcm-5 OS=Caenorhabditis
elegans GN=mcm-5 PE=2 SV=1
Length = 759
Score = 373 bits (957), Expect = 2e-102
Identities = 193/320 (60%), Positives = 234/320 (73%), Gaps = 6/320 (1%)
Frame = -3
Query: 1689 NPEDVPTGELPRNMLLSVDRHLVQLIVPGTILTVMGIYSIFQASSSSNSHKGAVAIRQPY 1510
NPEDVP GE+PR++ L +R+L +VPG +T++G+YSI + K IR PY
Sbjct: 233 NPEDVPHGEMPRHLQLFTERYLTDKVVPGNRVTIVGVYSIKKLIQKKGGDKSLQGIRTPY 292
Query: 1509 VRVVGLEDTNEASSRGPAN---FTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKR 1339
+RV+G+ E S G N FTP+EE FK A +D Y I IAPSI+G D+K+
Sbjct: 293 LRVLGIH--METSGPGRTNFTTFTPEEERMFKTLAQRKDAYELIAKSIAPSIYGSADIKK 350
Query: 1338 AVACLLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSA 1159
++ACLLFGG+RK LPDG+ RGDINVLLLGDP TAKSQ LKFVE+ +PI VYTSGKGSSA
Sbjct: 351 SIACLLFGGARKKLPDGITRRGDINVLLLGDPGTAKSQLLKFVEQVSPIGVYTSGKGSSA 410
Query: 1158 AGLTASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAK 979
AGLTASVIRD +R F +EGGAMVLADGGVVCIDEFDKMR +DRVAIHEAMEQQTISIAK
Sbjct: 411 AGLTASVIRDPQSRSFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAK 470
Query: 978 AGITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDK 799
AGITT LNSR SVLAAAN GR+D+ + DNID TILSRFD+I+IVKD+ + +D
Sbjct: 471 AGITTTLNSRCSVLAAANSVYGRWDESR-GDDNIDFMPTILSRFDMIYIVKDTHDVLKDA 529
Query: 798 EIASHIIRVHASADKVTDEN 739
+A H+I VH +A + +
Sbjct: 530 TLAKHVIEVHVNASAAKERD 549
>sp|P40377|MCM2_SCHPO DNA replication licensing factor mcm2
OS=Schizosaccharomyces pombe GN=mcm2 PE=1 SV=1
Length = 830
Score = 313 bits (801), Expect = 3e-084
Identities = 184/445 (41%), Positives = 266/445 (59%), Gaps = 23/445 (5%)
Frame = -3
Query: 1686 PEDVPTGELPRNMLLSVDRHLVQLIVPGTILTVMGIY-SIFQASSSSNSHKGAVAIRQPY 1510
P VP+G LPR+ + + LV + PG + V GIY + F AS ++ + A
Sbjct: 387 PGTVPSGRLPRHREVILLADLVDVAKPGEEIDVTGIYRNNFDASLNTKNGFPVFATIIEA 446
Query: 1509 VRVVGLEDT-NEASSRGPANFTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAV 1333
+ L+ + N + T DEE E + A S D+++ I +APSI+GH +K A+
Sbjct: 447 NHISQLDGSGNTDDDFSLSRLTDDEEREIRALAKSPDIHNRIIASMAPSIYGHRSIKTAI 506
Query: 1332 ACLLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAG 1153
A LFGG K++ K+RGDINVLLLGDP TAKSQFLK+VEKTA AV+ +G+G+SA G
Sbjct: 507 AAALFGGVPKNINGKHKIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFATGQGASAVG 566
Query: 1152 LTASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAG 973
LTASV +D T E+ LEGGA+VLAD GV IDEFDKM +DR +IHEAMEQQ+ISI+KAG
Sbjct: 567 LTASVRKDPITNEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAG 626
Query: 972 ITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEI 793
I T L +R +++AAANP GRY+ N++L ILSRFD++ +VKD+ N + D+++
Sbjct: 627 IVTTLQARCTIIAAANPIGGRYNTTIPFNQNVELTEPILSRFDILQVVKDTVNPEIDEQL 686
Query: 792 ASHIIRVHASADKVTDENTDSKE--------------DNWLKRYIQYCRSRCHPRLTESA 655
A+ ++ H + D N D + + L++YI + R + PRL +
Sbjct: 687 ANFVVSSHIRSHPAFDPNMDVLKKVPTETGIDAKPIPQDLLRKYIHFAREKVFPRLQQMD 746
Query: 654 AMKLQQYYVTIREDMKRSAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHDATEDDVE 475
K+ + Y DM+R + TG PITVR LE+ +RLSE+ AKM+LS ++
Sbjct: 747 EEKISRLY----SDMRRESLATGS---YPITVRHLESAIRLSEAFAKMQLSEFVRPSHID 799
Query: 474 KAYKLFKTATMDAAKSGINQQINIT 400
KA ++ + ++A K + + ++ T
Sbjct: 800 KAIQVIIDSFVNAQKMSVKRSLSRT 824
>sp|P43299|PROL_ARATH Protein PROLIFERA OS=Arabidopsis thaliana GN=PRL PE=1
SV=2
Length = 716
Score = 306 bits (783), Expect = 3e-082
Identities = 179/483 (37%), Positives = 272/483 (56%), Gaps = 25/483 (5%)
Frame = -3
Query: 1692 ENPEDVPTGELPRNMLLSVDRHLVQLIVPGTILTVMGIYSIFQASSSSNSHKGAVAIRQP 1513
E E VP G +PR+M + + L + + PG ++ GI+ + G VA
Sbjct: 233 ELAEHVPKGHIPRSMTVHLRGELTRKVSPGDVVEFSGIFLPIPYTGFKALRAGLVA--DT 290
Query: 1512 YVRVVGLEDTNEASSRGPANFTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAV 1333
Y+ + T+ F DEEE+ + A D+Y+ + +AP I+GH D+K+A+
Sbjct: 291 YLEATSV--THFKKKYEEYEFQKDEEEQIARLAEDGDIYNKLSRSLAPEIYGHEDIKKAL 348
Query: 1332 ACLLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAG 1153
LL G + L DG+K+RGD+++ L+GDP AKSQ LK + AP VYT+GKGSS G
Sbjct: 349 LLLLVGAPHRQLKDGMKIRGDVHICLMGDPGVAKSQLLKHIINVAPRGVYTTGKGSSGVG 408
Query: 1152 LTASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAG 973
LTA+V+RD T E LEGGA+VLAD G+ IDEFDKM DR AIHE MEQQT+SIAKAG
Sbjct: 409 LTAAVMRDQVTNEMVLEGGALVLADMGICAIDEFDKMDESDRTAIHEVMEQQTVSIAKAG 468
Query: 972 ITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEI 793
ITT LN+RT+VLAAANP GRYD +T +NI+L +LSRFDL++++ D + D D E+
Sbjct: 469 ITTSLNARTAVLAAANPAWGRYDLRRTPAENINLPPALLSRFDLLWLILDRADMDSDLEL 528
Query: 792 ASHIIRVHASADKVTDENTDSKEDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTIRED 613
A H++ VH + + + E N L+ YI R RL+ +L++Y T
Sbjct: 529 AKHVLHVHQTEESPA-LGFEPLEPNILRAYISAAR-----RLSPYVPAELEEYIATAYSS 582
Query: 612 MKRSAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHDATEDDVEKAYKLFKTATM--- 442
+++ ++ TVR L +I+R+S +LA++R S + DV++A +L + + +
Sbjct: 583 IRQEEAKSNTPHSY-TTVRTLLSILRISAALARLRFSESVAQSDVDEALRLMQMSKISLY 641
Query: 441 --DAAKSGINQQINITSEMAKEIKQAETQIKRRMGIGARLSERRLIEDLARMGMNESMVR 268
D K+G++ + S + E +++ +S + ++R G +E+ ++
Sbjct: 642 ADDRQKAGLDAISDTYSIIRDEAARSKK---------THVSYANALNWISRKGYSEAQLK 692
Query: 267 RAL 259
L
Sbjct: 693 ECL 695
>sp|O75001|MCM7_SCHPO DNA replication licensing factor mcm7
OS=Schizosaccharomyces pombe GN=mcm7 PE=1 SV=1
Length = 760
Score = 292 bits (745), Expect = 9e-078
Identities = 181/481 (37%), Positives = 264/481 (54%), Gaps = 26/481 (5%)
Frame = -3
Query: 1692 ENPEDVPTGELPRNMLLSVDRHLVQLIVPGTILTVMGIYSIFQASSSSNSHKGAVA---I 1522
E VP G +PR++ + + + + + PG I+ + GI+ + G + +
Sbjct: 260 ELTNQVPIGHIPRSLTVHLYGAITRSVNPGDIVDISGIFLPTPYTGFRAMRAGLLTDTYL 319
Query: 1521 RQPYVRVVGLEDTNEASSRGPANFTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVK 1342
YV + TN TP E + +VY + IAP I+GH DVK
Sbjct: 320 ECHYVSQIIKNYTN-------IEKTPQSEAAIAELNQGGNVYEKLAKSIAPEIYGHEDVK 372
Query: 1341 RAVACLLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSS 1162
+A+ LL GG K L DG+++RGDIN+ L GDP AKSQ LK++ K AP VYT+G+GSS
Sbjct: 373 KALLLLLVGGVTKELGDGMRIRGDINICLTGDPGVAKSQLLKYISKVAPRGVYTTGRGSS 432
Query: 1161 AAGLTASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIA 982
GLTA+V+RD T E LEGGA+VLAD G+ CIDEFDKM DR AIHE MEQQTISI+
Sbjct: 433 GVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISIS 492
Query: 981 KAGITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQD 802
KAGITT LN+RTS+LAAANP GRY+ NI+L +LSRFD++F++ D+ + + D
Sbjct: 493 KAGITTTLNARTSILAAANPLYGRYNPKVAPIHNINLPAALLSRFDILFLILDTPSRETD 552
Query: 801 KEIASHIIRVHASADKVTDENTDSKEDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTI 622
+ +A H+ VH ++ + + + N ++ YI R + P + + + YV +
Sbjct: 553 EHLAQHVTYVHMHNEQ-PKMDFEPLDPNMIRHYISSAR-QYRPVVPKDVCDYVTGAYVQL 610
Query: 621 REDMKRSAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHDATEDDVEKAYKLFKTATM 442
R++ KR E E T R L AI+R+ ++LA++R S+ DV++A +L M
Sbjct: 611 RQNQKRD--EANERQFAHTTPRTLLAILRMGQALARLRFSNRVEIGDVDEALRL-----M 663
Query: 441 DAAKSGINQQIN-------ITSEMAKEIKQAETQIKRRMGIGARLSERRLIEDLARMGMN 283
+KS + ++ ITS++ K I+ I G L+ R + E + G
Sbjct: 664 SVSKSSLYDDLDPSSHDTTITSKIYKIIRDMLNSIPDVEGNERSLTLRAIRERVLAKGFT 723
Query: 282 E 280
E
Sbjct: 724 E 724
>sp|P49739|MCM3M_XENLA Maternal DNA replication licensing factor mcm3 OS=Xenopus
laevis GN=mmcm3 PE=1 SV=2
Length = 807
Score = 277 bits (707), Expect = 2e-073
Identities = 151/311 (48%), Positives = 200/311 (64%), Gaps = 11/311 (3%)
Frame = -3
Query: 1692 ENPEDVPTGELPRNMLLSVDRHLVQLIVPGTILTVMGIYSIFQASSSSNSHKGAVAIRQP 1513
E PE P G+LPR++ + D LV PG + ++GIY +
Sbjct: 203 EMPEKAPAGQLPRSVDIIADDDLVDKCKPGDRVQIVGIYRCLPSKQG--------GFTSG 254
Query: 1512 YVRVVGLEDTNEASSRGPA-NFTPDEEEEFKKF--AASQDVYSNICTKIAPSIFGHGDVK 1342
R + L + + S+ A F+ D+ + KKF A S+D++ ++ +APSI GH +K
Sbjct: 255 TFRTILLANNIKLMSKEIAPTFSADDVAKIKKFCKAHSKDIFEHLSKSLAPSIHGHEYIK 314
Query: 1341 RAVACLLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSS 1162
+A+ C+L GG+ K L +G ++RGDINVLL+GDPS AKSQ L++V TAP A+ T+G+GSS
Sbjct: 315 KAILCMLLGGNEKVLENGTRIRGDINVLLIGDPSVAKSQLLRYVLHTAPRAIPTTGRGSS 374
Query: 1161 AAGLTASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIA 982
GLTA+V D T E LE GAMVLAD GVVCIDEFDKM DR AIHE MEQ ++IA
Sbjct: 375 GVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIA 434
Query: 981 KAGITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQD 802
KAGI LN+R SVLAAANP GRYD +T +NI LQ ++LSRFDL+FIV D + D D
Sbjct: 435 KAGIQARLNARCSVLAAANPVYGRYDQYRTPMENIGLQDSLLSRFDLLFIVLDKMDADND 494
Query: 801 KEIASHIIRVH 769
+EIA H++R+H
Sbjct: 495 QEIADHVLRMH 505
>sp|Q86B14|MCM6_DICDI DNA replication licensing factor mcm6 OS=Dictyostelium
discoideum GN=mcm6 PE=3 SV=1
Length = 867
Score = 272 bits (694), Expect = 7e-072
Identities = 137/275 (49%), Positives = 186/275 (67%), Gaps = 4/275 (1%)
Frame = -3
Query: 1440 EEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAVACLLFGGSRKSLPDGVKLRGDINV 1261
E++ KK S+ +Y N+ I PSIFGH ++KR V +LFGG K P+ ++LRGDINV
Sbjct: 407 EKDSLKKMIKSKKIYQNLVNSICPSIFGHEEIKRGVLLMLFGGVHKKTPEKIRLRGDINV 466
Query: 1260 LLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLTASVIRDSSTREFYLEGGAMVLA 1081
++GDPST+KS FLK++ P VYTSGK SSAAGLTA+V++D + +F +E GA++LA
Sbjct: 467 CIVGDPSTSKSTFLKYLVSFLPRTVYTSGKASSAAGLTATVVKDQESGDFNIEAGALMLA 526
Query: 1080 DGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPPSGRYDD 901
D G+ CIDEFDKM P D+VAIHEAMEQQTISIAKAGI LN+RTS+LAAANP GRYD
Sbjct: 527 DNGICCIDEFDKMEPGDQVAIHEAMEQQTISIAKAGIHASLNARTSILAAANPIGGRYDR 586
Query: 900 LKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEIASHIIRVHASADKVTDENTDSKED 721
KT + N+++ ++SRFDL F+V D N + D IA HI+ H +K + + E
Sbjct: 587 NKTLKQNLNIGGPLMSRFDLFFVVLDECNPESDHRIAEHIVLTHQKREKAFNAPFSATE- 645
Query: 720 NWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTIRE 616
+K YI+Y + C P + + + L +Y +R+
Sbjct: 646 --IKNYIKYTKFIC-PTIPDESVQLLVGHYDRLRQ 677
>sp|P53091|MCM6_YEAST DNA replication licensing factor MCM6 OS=Saccharomyces
cerevisiae GN=MCM6 PE=1 SV=1
Length = 1017
Score = 267 bits (682), Expect = 2e-070
Identities = 144/311 (46%), Positives = 202/311 (64%), Gaps = 9/311 (2%)
Frame = -3
Query: 1455 NFTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAVACLLFGGSRKSLPDGVKLR 1276
+ + DE E K+ + +Y + IAP++FGH VK+ + + GG KS +G+KLR
Sbjct: 507 SLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGGVHKSTVEGIKLR 566
Query: 1275 GDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLTASVIRDSSTREFYLEGG 1096
GDIN+ ++GDPST+KSQFLK+V AP +VYTSGK SSAAGLTA+V+RD ++ +E G
Sbjct: 567 GDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEEGGDYTIEAG 626
Query: 1095 AMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPPS 916
A++LAD G+ CIDEFDKM D+VAIHEAMEQQTISIAKAGI LN+RTS+LAAANP
Sbjct: 627 ALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNARTSILAAANPVG 686
Query: 915 GRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEIASHIIRVHASADKVTDENT 736
GRY+ + + N+++ I+SRFDL F++ D N D E+ASHI+ +H D+ +
Sbjct: 687 GRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDLHMKRDEAIEPPF 746
Query: 735 DSKEDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTIRED----MKRSAHETGEAAPIP 568
+++ L+RYI+Y R+ P LT+ A L + Y +R+D RS++ +
Sbjct: 747 SAEQ---LRRYIKYART-FKPILTKEARSYLVEKYKELRKDDAQGFSRSSYRI-TVRQLE 801
Query: 567 ITVRQLEAIVR 535
+R EAI R
Sbjct: 802 SMIRLSEAIAR 812
>sp|Q14566|MCM6_HUMAN DNA replication licensing factor MCM6 OS=Homo sapiens
GN=MCM6 PE=1 SV=1
Length = 821
Score = 262 bits (669), Expect = 6e-069
Identities = 141/293 (48%), Positives = 196/293 (66%), Gaps = 4/293 (1%)
Frame = -3
Query: 1494 LEDTNEASSRGPANFTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAVACLLFG 1315
L D + + T E E+ + + +++Y N+CT + P+I G+ +VKR V +LFG
Sbjct: 315 LRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFG 374
Query: 1314 GSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLTASVI 1135
G K+ +G LRGDINV ++GDPSTAKSQFLK VE+ +P AVYTSGK SSAAGLTA+V+
Sbjct: 375 GVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVV 434
Query: 1134 RDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGITTVLN 955
RD + EF +E GA++LAD GV CIDEFDKM D+VAIHEAMEQQTISI KAG+ LN
Sbjct: 435 RDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLN 494
Query: 954 SRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEIASHIIR 775
+RTS+LAAANP SG YD K+ + NI+L I+SRFDL FI+ D N D IA I+
Sbjct: 495 ARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVD 554
Query: 774 VHASADKVTDENTDSKEDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTIRE 616
+H+ ++ D S +D ++RY+ + R + P++++ + + + Y +R+
Sbjct: 555 LHSRIEESID-RVYSLDD--IRRYLLFAR-QFKPKISKESEDFIVEQYKHLRQ 603
>sp|Q62724|MCM6_RAT DNA replication licensing factor MCM6 (Fragment) OS=Rattus
norvegicus GN=Mcm6 PE=2 SV=2
Length = 507
Score = 262 bits (669), Expect = 6e-069
Identities = 140/293 (47%), Positives = 196/293 (66%), Gaps = 4/293 (1%)
Frame = -3
Query: 1494 LEDTNEASSRGPANFTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAVACLLFG 1315
L D + + T E E+ + + Q++Y N+CT + P+I G+ +VKR V +LFG
Sbjct: 1 LRDEEQTAESIKNQMTVKEWEKVFEMSQDQNLYHNLCTSLFPTIHGNDEVKRGVLLMLFG 60
Query: 1314 GSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLTASVI 1135
G K+ +G LRGDINV ++GDPSTAKSQFLK V++ +P AVYTSGK SSA+GLTA+V+
Sbjct: 61 GVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSASGLTAAVV 120
Query: 1134 RDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGITTVLN 955
RD + EF +E GA++LAD GV CIDEFDKM D+VAIHEAMEQQTISI KAG+ LN
Sbjct: 121 RDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLN 180
Query: 954 SRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEIASHIIR 775
+RTS+LAAANP SG YD K+ + NI+L I+SRFDL FI+ D N D IA I+
Sbjct: 181 ARTSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVD 240
Query: 774 VHASADKVTDENTDSKEDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTIRE 616
+H+ ++ D S +D ++RY+ + R + P++++ + + + Y +R+
Sbjct: 241 LHSRIEESID-RVYSLDD--IRRYLLFAR-QFKPKISKESEDFIVEQYKRLRQ 289
>sp|Q498J7|MC6ZA_XENLA Zygotic DNA replication licensing factor mcm6-A
OS=Xenopus laevis GN=zmcm6-a PE=1 SV=1
Length = 823
Score = 262 bits (668), Expect = 8e-069
Identities = 137/272 (50%), Positives = 189/272 (69%), Gaps = 6/272 (2%)
Frame = -3
Query: 1425 KKFAASQD--VYSNICTKIAPSIFGHGDVKRAVACLLFGGSRKSLPDGVKLRGDINVLLL 1252
K F SQD +Y N+CT + P++ G+ +VKR + +LFGG KS +G LRGDINV ++
Sbjct: 337 KVFEMSQDKNLYHNLCTSLFPTVHGNDEVKRGILLMLFGGVPKSTMEGTSLRGDINVCVV 396
Query: 1251 GDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLTASVIRDSSTREFYLEGGAMVLADGG 1072
GDPSTAKSQFLK VE+ +P AVYTSGK S+AAGLTA+V++D + EF +E GA++LAD G
Sbjct: 397 GDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAGLTAAVVKDEESHEFVIEAGALMLADNG 456
Query: 1071 VVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPPSGRYDDLKT 892
V CIDEFDKM +D+VAIHEAMEQQTISI KAG+ LN+RTS+LAAANP GRYD K+
Sbjct: 457 VCCIDEFDKMDTKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYDRAKS 516
Query: 891 AQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEIASHIIRVHASADKVTDENTDSKEDNWL 712
+ N++L I+SRFDL FI+ D N D IA I+ +H+ ++ D E +
Sbjct: 517 LKQNVNLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVYTVDE---V 573
Query: 711 KRYIQYCRSRCHPRLTESAAMKLQQYYVTIRE 616
+RY+ + R + P++++ +A + + Y +R+
Sbjct: 574 RRYLLFAR-QFKPKISKESADFIVEQYKRLRQ 604
>sp|Q5FWY4|MCM6M_XENLA Maternal DNA replication licensing factor mcm6 OS=Xenopus
laevis GN=mmcm6 PE=1 SV=1
Length = 821
Score = 262 bits (668), Expect = 8e-069
Identities = 139/293 (47%), Positives = 199/293 (67%), Gaps = 4/293 (1%)
Frame = -3
Query: 1494 LEDTNEASSRGPANFTPDEEEEFKKFAASQDVYSNICTKIAPSIFGHGDVKRAVACLLFG 1315
L + ++ + T E E+ + + +++Y N+CT + P+I G+ ++KR V +LFG
Sbjct: 317 LREEDQTAESIKNQMTVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEIKRGVLLMLFG 376
Query: 1314 GSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSGKGSSAAGLTASVI 1135
G K+ +G LRGDINV ++GDPST+KSQFLK VE+ +P AVYTSGK SSAAGLTA+V+
Sbjct: 377 GVPKTTMEGTSLRGDINVCIVGDPSTSKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVV 436
Query: 1134 RDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGITTVLN 955
+D + EF +E GA++LAD GV CIDEFDKM +D+VAIHEAMEQQTISI KAG+ LN
Sbjct: 437 KDEESHEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLN 496
Query: 954 SRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDSRNFDQDKEIASHIIR 775
+RTS+LAAANP GRY+ K+ + N++L I+SRFDL FI+ D N D IA I+
Sbjct: 497 ARTSILAAANPVGGRYERSKSLKHNVNLSAPIMSRFDLFFILVDECNEVTDYAIARRIVD 556
Query: 774 VHASADKVTDENTDSKEDNWLKRYIQYCRSRCHPRLTESAAMKLQQYYVTIRE 616
+HA ++ + E S ED ++RY+ + R + P++T+ A + + Y +R+
Sbjct: 557 LHARNEE-SIERVYSIED--IQRYLLFAR-QFQPKITKEAEEFIVEQYRRLRQ 605
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,545,185,555
Number of Sequences: 518415
Number of Extensions: 16545185555
Number of Successful Extensions: 102511304
Number of sequences better than 0.0: 0
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