BLASTX 7.6.2
Query= UN03977 /QuerySize=1457
(1456 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9STN8|SINA4_ARATH E3 ubiquitin-protein ligase SINAT4 OS=Arab... 607 6e-173
sp|Q84JL3|SINA3_ARATH E3 ubiquitin-protein ligase SINAT3 OS=Arab... 523 2e-147
sp|Q8S3N1|SINA5_ARATH E3 ubiquitin-protein ligase SINAT5 OS=Arab... 522 4e-147
sp|Q9M2P4|SINA2_ARATH E3 ubiquitin-protein ligase SINAT2 OS=Arab... 453 2e-126
sp|P93748|SINA1_ARATH Putative E3 ubiquitin-protein ligase SINAT... 447 1e-124
sp|Q86MW9|SINA_SCHMA E3 ubiquitin-protein ligase sina OS=Schisto... 168 2e-040
sp|P61092|SIA1A_MOUSE E3 ubiquitin-protein ligase SIAH1A OS=Mus ... 162 7e-039
sp|Q7ZVG6|SIAH1_DANRE E3 ubiquitin-protein ligase Siah1 OS=Danio... 162 7e-039
sp|Q920M9|SIAH1_RAT E3 ubiquitin-protein ligase SIAH1 OS=Rattus ... 162 7e-039
sp|Q8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 OS=Homo ... 161 1e-038
sp|Q06985|SIA1B_MOUSE E3 ubiquitin-protein ligase SIAH1B OS=Mus ... 159 7e-038
sp|Q8I147|SINA_DROWI E3 ubiquitin-protein ligase sina OS=Drosoph... 154 2e-036
sp|P61093|SINA_DROER E3 ubiquitin-protein ligase sina OS=Drosoph... 151 1e-035
sp|P21461|SINA_DROME E3 ubiquitin-protein ligase sina OS=Drosoph... 151 1e-035
sp|Q9I8X5|SIAH2_XENLA E3 ubiquitin-protein ligase siah2 OS=Xenop... 150 3e-035
sp|P29304|SINA_DROVI E3 ubiquitin-protein ligase sina OS=Drosoph... 149 5e-035
sp|O43255|SIAH2_HUMAN E3 ubiquitin-protein ligase SIAH2 OS=Homo ... 148 1e-034
sp|Q06986|SIAH2_MOUSE E3 ubiquitin-protein ligase SIAH2 OS=Mus m... 148 1e-034
sp|Q8R4T2|SIAH2_RAT E3 ubiquitin-protein ligase SIAH2 OS=Rattus ... 148 1e-034
sp|Q7SYL3|SIAH2_DANRE E3 ubiquitin-protein ligase Siah2 OS=Danio... 148 2e-034
>sp|Q9STN8|SINA4_ARATH E3 ubiquitin-protein ligase SINAT4 OS=Arabidopsis
thaliana GN=SINAT4 PE=2 SV=1
Length = 327
Score = 607 bits (1565), Expect = 6e-173
Identities = 293/329 (89%), Positives = 303/329 (92%), Gaps = 10/329 (3%)
Frame = -1
Query: 1108 METDSMESSTRSSQNDEVHHNGG---TFHFSSTKSHSSAAASPTVVTNIVGPT----ATS 950
METDSME SS +E+H NG ++ FSSTK+H AAA+ VVTNIVGPT ATS
Sbjct: 1 METDSMECV--SSTGNEIHQNGNGHQSYQFSSTKTHGGAAAA-AVVTNIVGPTATAPATS 57
Query: 949 VYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAES 770
VYELLECPVCT SMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAES
Sbjct: 58 VYELLECPVCTYSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAES 117
Query: 769 LELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHK 590
LELPCKFYNLGCPEIFPYYSKLKHESLCNFRPY CPYAGSECG+VGDIPFLV+HLRDDHK
Sbjct: 118 LELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYSCPYAGSECGIVGDIPFLVAHLRDDHK 177
Query: 589 VDMHAGSTFNHRYVKSNPREVENATWMLTVFQCFGQYFCLHFEAFQLGMGPVYMAFLRFM 410
VDMHAGSTFNHRYVKSNPREVENATWMLTVF CFGQYFCLHFEAFQLGMGPVYMAFLRFM
Sbjct: 178 VDMHAGSTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMGPVYMAFLRFM 237
Query: 409 GDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMAFFFSGGDR 230
GDEE+ARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMA FFSGGDR
Sbjct: 238 GDEEDARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDR 297
Query: 229 KEPKLRVTGKIWKEQHSPDSGLFMPNLSS 143
KE KLRVTGKIWKEQHSPDSGL +PNLSS
Sbjct: 298 KELKLRVTGKIWKEQHSPDSGLSIPNLSS 326
>sp|Q84JL3|SINA3_ARATH E3 ubiquitin-protein ligase SINAT3 OS=Arabidopsis
thaliana GN=SINAT3 PE=2 SV=1
Length = 326
Score = 523 bits (1345), Expect = 2e-147
Identities = 252/326 (77%), Positives = 272/326 (83%), Gaps = 5/326 (1%)
Frame = -1
Query: 1108 METDSME-SSTRSSQNDEVHHNGGTFHFSSTKSHSSAAASPTVVTNIVG--PTATSVYEL 938
M+ DSM+ +ST +DE H + S +K H + + V G PT TSV+EL
Sbjct: 1 MDLDSMDCTSTMDVTDDEEIHQDRHSYASVSKHHHTNNNTTNVNAAASGLLPTTTSVHEL 60
Query: 937 LECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAESLELP 758
LECPVCT SMYPPIHQCHNGHTLCSTCK RVHNRCPTCRQELGDIRCLALEKVAESLELP
Sbjct: 61 LECPVCTNSMYPPIHQCHNGHTLCSTCKARVHNRCPTCRQELGDIRCLALEKVAESLELP 120
Query: 757 CKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHKVDMH 578
CK +LGCPEIFPYYSKLKHE++CNFRPY CPYAGSEC V GDIPFLV+HLRDDHKVDMH
Sbjct: 121 CKHMSLGCPEIFPYYSKLKHETVCNFRPYSCPYAGSECSVTGDIPFLVAHLRDDHKVDMH 180
Query: 577 AGSTFNHRYVKSNPREVENATWMLTVFQCFGQYFCLHFEAFQLGMGPVYMAFLRFMGDEE 398
+G TFNHRYVKSNPREVENATWMLTVF CFGQYFCLHFEAFQLGM PVYMAFLRFMGDE
Sbjct: 181 SGCTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMAPVYMAFLRFMGDET 240
Query: 397 EARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMAFFFSGGDRKEPK 218
EAR+Y+YSLEVGG GRKL WEGTPRS+RDSHRKVRDS+DGLIIQRNMA FFSGGDRKE K
Sbjct: 241 EARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDGLIIQRNMALFFSGGDRKELK 300
Query: 217 LRVTGKIWKEQH--SPDSGLFMPNLS 146
LRVTG+IWKEQ G +PNLS
Sbjct: 301 LRVTGRIWKEQQQSGEGGGACIPNLS 326
>sp|Q8S3N1|SINA5_ARATH E3 ubiquitin-protein ligase SINAT5 OS=Arabidopsis
thaliana GN=SINAT5 PE=1 SV=2
Length = 309
Score = 522 bits (1342), Expect = 4e-147
Identities = 243/292 (83%), Positives = 261/292 (89%), Gaps = 1/292 (0%)
Frame = -1
Query: 1018 KSHSSAAASPTVVTNIVGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHN 839
K S+ S T ++ P ATSVYELLECPVCT SMYPPIHQCHNGHTLCSTCK RVHN
Sbjct: 18 KHQFSSTKSQGGATVVISP-ATSVYELLECPVCTNSMYPPIHQCHNGHTLCSTCKSRVHN 76
Query: 838 RCPTCRQELGDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPY 659
RCPTCRQELGDIRCLALEKVAESLELPCK+YNLGC IFPYYSKLKHES CNFRPY CPY
Sbjct: 77 RCPTCRQELGDIRCLALEKVAESLELPCKYYNLGCLGIFPYYSKLKHESQCNFRPYSCPY 136
Query: 658 AGSECGVVGDIPFLVSHLRDDHKVDMHAGSTFNHRYVKSNPREVENATWMLTVFQCFGQY 479
AGSEC VGDI FLV+HLRDDHKVDMH G TFNHRYVKSNPREVENATWMLTVFQCFGQY
Sbjct: 137 AGSECAAVGDITFLVAHLRDDHKVDMHTGCTFNHRYVKSNPREVENATWMLTVFQCFGQY 196
Query: 478 FCLHFEAFQLGMGPVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRK 299
FCLHFEAFQLGM PVYMAFLRFMGDE++AR+Y+YSLEVGGSGRK TWEGTPRS+RDSHRK
Sbjct: 197 FCLHFEAFQLGMAPVYMAFLRFMGDEDDARNYTYSLEVGGSGRKQTWEGTPRSVRDSHRK 256
Query: 298 VRDSNDGLIIQRNMAFFFSGGDRKEPKLRVTGKIWKEQHSPDSGLFMPNLSS 143
VRDS+DGLIIQRNMA FFSGGD+KE KLRVTG+IWKEQ +PDSG+ + ++ S
Sbjct: 257 VRDSHDGLIIQRNMALFFSGGDKKELKLRVTGRIWKEQQNPDSGVCITSMCS 308
>sp|Q9M2P4|SINA2_ARATH E3 ubiquitin-protein ligase SINAT2 OS=Arabidopsis
thaliana GN=SINAT2 PE=2 SV=1
Length = 308
Score = 453 bits (1164), Expect = 2e-126
Identities = 207/255 (81%), Positives = 223/255 (87%)
Frame = -1
Query: 949 VYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAES 770
VYELLECPVCT MYPPIHQC NGHTLCS CK+RV N CPTCR ELG+IRCLALEKVAES
Sbjct: 54 VYELLECPVCTNLMYPPIHQCPNGHTLCSNCKLRVQNTCPTCRYELGNIRCLALEKVAES 113
Query: 769 LELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHK 590
LE+PC++ NLGC +IFPYYSKLKHE C FRPY CPYAGSEC V GDIP LV HL+DDHK
Sbjct: 114 LEVPCRYQNLGCHDIFPYYSKLKHEQHCRFRPYTCPYAGSECSVTGDIPTLVVHLKDDHK 173
Query: 589 VDMHAGSTFNHRYVKSNPREVENATWMLTVFQCFGQYFCLHFEAFQLGMGPVYMAFLRFM 410
VDMH G TFNHRYVKSNP EVENATWMLTVF CFG+ FCLHFEAFQLGM PVYMAFLRFM
Sbjct: 174 VDMHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFM 233
Query: 409 GDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMAFFFSGGDR 230
GDE EA+ +SYSLEVG GRKLTW+G PRSIRDSHRKVRDS DGLII RN+A +FSGGDR
Sbjct: 234 GDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDR 293
Query: 229 KEPKLRVTGKIWKEQ 185
+E KLRVTG+IWKE+
Sbjct: 294 QELKLRVTGRIWKEE 308
>sp|P93748|SINA1_ARATH Putative E3 ubiquitin-protein ligase SINAT1
OS=Arabidopsis thaliana GN=SINAT1 PE=2 SV=1
Length = 305
Score = 447 bits (1149), Expect = 1e-124
Identities = 203/259 (78%), Positives = 223/259 (86%)
Frame = -1
Query: 961 TATSVYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEK 782
++ VYELLECPVCT MYPPIHQC NGHTLCS+CK+RV N CPTCR ELG+IRCLALEK
Sbjct: 47 SSNGVYELLECPVCTNLMYPPIHQCPNGHTLCSSCKLRVQNTCPTCRYELGNIRCLALEK 106
Query: 781 VAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLVSHLR 602
VAESLE+PC++ NLGC +IFPYYSKLKHE C FR Y CPYAGSEC V GDIP LV HL+
Sbjct: 107 VAESLEVPCRYQNLGCQDIFPYYSKLKHEQHCRFRSYSCPYAGSECSVTGDIPTLVDHLK 166
Query: 601 DDHKVDMHAGSTFNHRYVKSNPREVENATWMLTVFQCFGQYFCLHFEAFQLGMGPVYMAF 422
DDHKVDMH G TFNHRYVKSNP EVENATWMLTVF CFG+ FCLHFEAFQLGM PVYMAF
Sbjct: 167 DDHKVDMHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAF 226
Query: 421 LRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMAFFFS 242
LRFMGDE EA+ +SYSLEVG RKLTW+G PRSIRDSHRKVRDS DGLII RN+A +FS
Sbjct: 227 LRFMGDENEAKKFSYSLEVGAHSRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFS 286
Query: 241 GGDRKEPKLRVTGKIWKEQ 185
G D++E KLRVTG+IWKE+
Sbjct: 287 GSDKEELKLRVTGRIWKEE 305
>sp|Q86MW9|SINA_SCHMA E3 ubiquitin-protein ligase sina OS=Schistosoma mansoni
GN=SINA PE=1 SV=1
Length = 371
Score = 168 bits (423), Expect = 2e-040
Identities = 93/275 (33%), Positives = 142/275 (51%), Gaps = 10/275 (3%)
Frame = -1
Query: 1048 NGGTFHFSSTKSHSSAAASPTVVTNIV-----GPTATSVYELLECPVCTCSMYPPIHQCH 884
N GT S S +++ V NI+ ++ + L ECPVC PPI QC
Sbjct: 82 NSGTASTCSMSLPGSMSSASDTVCNILPHNTSDSSSIDLASLFECPVCMDYALPPIMQCQ 141
Query: 883 NGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKL 704
+GH +C++C+ ++ + CPTCR L +IR LA+EK+A S+ PCK+ GCPE F Y SK
Sbjct: 142 SGHIVCASCRSKL-SSCPTCRGNLDNIRNLAMEKLASSVLFPCKYSTSGCPETFHYTSKS 200
Query: 703 KHESLCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYVKSNPREV 527
+HE+ C +RPY CP G+ C +G++ ++ HL HK + G + +
Sbjct: 201 EHEAACEYRPYDCPCPGASCKWLGELEQVMPHLVHHHKSITTLQGEDI---VFLATDISL 257
Query: 526 ENATWMLTVFQCFGQYFCLHFEAFQLGMGPVYMAFLRFMGDEEEARSYSYSLEVGGSGRK 347
A + + CFG F L E + ++ A ++ +G ++A + Y LE+ G R+
Sbjct: 258 PGAVDWVMMQSCFGHSFMLVLEKQERVPDQIFFALVQLIGTRKQADQFVYRLELNGHRRR 317
Query: 346 LTWEGTPRSIRDSHRKVRDSNDGLIIQRNMAFFFS 242
LTWE PRSI D + +D L+ N A F+
Sbjct: 318 LTWEACPRSIHDGVQSAIAVSDCLVFDSNTAHSFA 352
>sp|P61092|SIA1A_MOUSE E3 ubiquitin-protein ligase SIAH1A OS=Mus musculus
GN=Siah1a PE=1 SV=1
Length = 282
Score = 162 bits (409), Expect = 7e-039
Identities = 93/252 (36%), Positives = 138/252 (54%), Gaps = 10/252 (3%)
Frame = -1
Query: 982 VTNIVGPTATS--VYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELG 809
V + G TA++ + L ECPVC + PPI QC +GH +CS C+ ++ CPTCR LG
Sbjct: 22 VPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLG 80
Query: 808 DIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGD 629
IR LA+EKVA S+ PCK+ + GC P+ K +HE LC FRPY CP G+ C G
Sbjct: 81 SIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGS 140
Query: 628 IPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAF 455
+ ++ HL HK + G N P V+ W++ + CFG +F L E
Sbjct: 141 LDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQ 196
Query: 454 QLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDG 278
+ G + A ++ +G ++A +++Y LE+ G R+LTWE TPRSI + ++D
Sbjct: 197 EKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDC 256
Query: 277 LIIQRNMAFFFS 242
L+ ++A F+
Sbjct: 257 LVFDTSIAQLFA 268
>sp|Q7ZVG6|SIAH1_DANRE E3 ubiquitin-protein ligase Siah1 OS=Danio rerio GN=siah1
PE=2 SV=2
Length = 282
Score = 162 bits (409), Expect = 7e-039
Identities = 93/252 (36%), Positives = 138/252 (54%), Gaps = 10/252 (3%)
Frame = -1
Query: 982 VTNIVGPTATS--VYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELG 809
V + G TA++ + L ECPVC + PPI QC +GH +CS C+ ++ CPTCR LG
Sbjct: 22 VPTLSGTTASNSDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLG 80
Query: 808 DIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGD 629
IR LA+EKVA S+ PCK+ + GC P+ K +HE LC FRPY CP G+ C G
Sbjct: 81 SIRNLAMEKVANSVLFPCKYASSGCEVTLPHTDKAEHEELCEFRPYSCPCPGASCKWQGS 140
Query: 628 IPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAF 455
+ ++ HL HK + G N P V+ W++ + CFG +F L E
Sbjct: 141 LDAVMPHLLHQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQ 196
Query: 454 QLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDG 278
+ G + A ++ +G ++A +++Y LE+ G R+LTWE TPRSI + ++D
Sbjct: 197 EKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDC 256
Query: 277 LIIQRNMAFFFS 242
L+ ++A F+
Sbjct: 257 LVFDTSIAQLFA 268
>sp|Q920M9|SIAH1_RAT E3 ubiquitin-protein ligase SIAH1 OS=Rattus norvegicus
GN=Siah1 PE=1 SV=2
Length = 282
Score = 162 bits (409), Expect = 7e-039
Identities = 93/252 (36%), Positives = 138/252 (54%), Gaps = 10/252 (3%)
Frame = -1
Query: 982 VTNIVGPTATS--VYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELG 809
V + G TA++ + L ECPVC + PPI QC +GH +CS C+ ++ CPTCR LG
Sbjct: 22 VPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLG 80
Query: 808 DIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGD 629
IR LA+EKVA S+ PCK+ + GC P+ K +HE LC FRPY CP G+ C G
Sbjct: 81 SIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGS 140
Query: 628 IPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAF 455
+ ++ HL HK + G N P V+ W++ + CFG +F L E
Sbjct: 141 LDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQ 196
Query: 454 QLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDG 278
+ G + A ++ +G ++A +++Y LE+ G R+LTWE TPRSI + ++D
Sbjct: 197 EKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDC 256
Query: 277 LIIQRNMAFFFS 242
L+ ++A F+
Sbjct: 257 LVFDTSIAQLFA 268
>sp|Q8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 OS=Homo sapiens
GN=SIAH1 PE=1 SV=2
Length = 282
Score = 161 bits (407), Expect = 1e-038
Identities = 93/252 (36%), Positives = 137/252 (54%), Gaps = 10/252 (3%)
Frame = -1
Query: 982 VTNIVGPTATS--VYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELG 809
V + G TA++ + L ECPVC + PPI QC +GH +CS C+ ++ CPTCR LG
Sbjct: 22 VPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLG 80
Query: 808 DIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGD 629
IR LA+EKVA S+ PCK+ + GC P+ K HE LC FRPY CP G+ C G
Sbjct: 81 SIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGS 140
Query: 628 IPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAF 455
+ ++ HL HK + G N P V+ W++ + CFG +F L E
Sbjct: 141 LDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQ 196
Query: 454 QLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDG 278
+ G + A ++ +G ++A +++Y LE+ G R+LTWE TPRSI + ++D
Sbjct: 197 EKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDC 256
Query: 277 LIIQRNMAFFFS 242
L+ ++A F+
Sbjct: 257 LVFDTSIAQLFA 268
>sp|Q06985|SIA1B_MOUSE E3 ubiquitin-protein ligase SIAH1B OS=Mus musculus
GN=Siah1b PE=2 SV=2
Length = 282
Score = 159 bits (400), Expect = 7e-038
Identities = 89/236 (37%), Positives = 129/236 (54%), Gaps = 8/236 (3%)
Frame = -1
Query: 940 LLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAESLEL 761
L ECPVC + PPI QC +GH +CS C+ ++ CPTCR LG IR LA+EKVA S+
Sbjct: 38 LFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIRNLAVEKVANSVLF 96
Query: 760 PCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHK-VD 584
PCK+ GC P+ K +HE LC FRPY CP G+ C G + ++ HL HK +
Sbjct: 97 PCKYSASGCEITLPHTKKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSIT 156
Query: 583 MHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAFQLGMG-PVYMAFLRFM 410
G N P V+ W++ + CFG +F L E + G + A ++ +
Sbjct: 157 TLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLI 212
Query: 409 GDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMAFFFS 242
G ++A +++Y LE+ G R+LTWE TPRSI + ++D L+ ++A F+
Sbjct: 213 GTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFA 268
>sp|Q8I147|SINA_DROWI E3 ubiquitin-protein ligase sina OS=Drosophila willistoni
GN=sina PE=3 SV=1
Length = 331
Score = 154 bits (387), Expect = 2e-036
Identities = 91/274 (33%), Positives = 144/274 (52%), Gaps = 11/274 (4%)
Frame = -1
Query: 1045 GGTFHFSSTKSHSSAAASPTVVTNIVGPTA---TSVYELLECPVCTCSMYPPIHQCHNGH 875
GG+ +T S +++++S + +++ G A + L ECPVC + PPI QC +GH
Sbjct: 49 GGSSSAGTTSSANTSSSSSSSLSSAGGGDAGMSADLTSLFECPVCFDYVLPPILQCSSGH 108
Query: 874 TLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHE 695
+C +C+ ++ CPTCR L +IR LA+EKVA +++ PCK GC Y K +HE
Sbjct: 109 LVCVSCRSKL-TCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEKTEHE 167
Query: 694 SLCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVEN 521
C RPY CP G+ C G + ++ HL HK + G N P V+
Sbjct: 168 ETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDINLPGAVD- 226
Query: 520 ATWMLTVFQCFGQYFCLHFEAFQLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKL 344
W++ + CFG +F L E + G + A ++ +G +EA ++ Y LE+ G+ R+L
Sbjct: 227 --WVM-MQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRL 283
Query: 343 TWEGTPRSIRDSHRKVRDSNDGLIIQRNMAFFFS 242
TWE PRSI + ++D L+ ++A F+
Sbjct: 284 TWEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFA 317
>sp|P61093|SINA_DROER E3 ubiquitin-protein ligase sina OS=Drosophila erecta
GN=sina PE=3 SV=1
Length = 314
Score = 151 bits (381), Expect = 1e-035
Identities = 90/273 (32%), Positives = 143/273 (52%), Gaps = 11/273 (4%)
Frame = -1
Query: 1042 GTFHFSSTKSHSSAAASPTVVTNIVGPTA---TSVYELLECPVCTCSMYPPIHQCHNGHT 872
G+ +T S +++++S + +++ G A + L ECPVC + PPI QC +GH
Sbjct: 33 GSSSAGNTSSANTSSSSSSSLSSAGGGDAGMSADLTSLFECPVCFDYVLPPILQCSSGHL 92
Query: 871 LCSTCKVRVHNRCPTCRQELGDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHES 692
+C +C+ ++ CPTCR L +IR LA+EKVA +++ PCK GC Y K +HE
Sbjct: 93 VCVSCRSKL-TCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEKTEHEE 151
Query: 691 LCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENA 518
C RPY CP G+ C G + ++ HL HK + G N P V+
Sbjct: 152 TCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDINLPGAVD-- 209
Query: 517 TWMLTVFQCFGQYFCLHFEAFQLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLT 341
W++ + CFG +F L E + G + A ++ +G +EA ++ Y LE+ G+ R+LT
Sbjct: 210 -WVM-MQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLT 267
Query: 340 WEGTPRSIRDSHRKVRDSNDGLIIQRNMAFFFS 242
WE PRSI + ++D L+ ++A F+
Sbjct: 268 WEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFA 300
>sp|P21461|SINA_DROME E3 ubiquitin-protein ligase sina OS=Drosophila
melanogaster GN=sina PE=1 SV=2
Length = 314
Score = 151 bits (381), Expect = 1e-035
Identities = 90/273 (32%), Positives = 143/273 (52%), Gaps = 11/273 (4%)
Frame = -1
Query: 1042 GTFHFSSTKSHSSAAASPTVVTNIVGPTA---TSVYELLECPVCTCSMYPPIHQCHNGHT 872
G+ +T S +++++S + +++ G A + L ECPVC + PPI QC +GH
Sbjct: 33 GSSSAGNTSSANTSSSSSSSLSSAGGGDAGMSADLTSLFECPVCFDYVLPPILQCSSGHL 92
Query: 871 LCSTCKVRVHNRCPTCRQELGDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHES 692
+C +C+ ++ CPTCR L +IR LA+EKVA +++ PCK GC Y K +HE
Sbjct: 93 VCVSCRSKL-TCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEKTEHEE 151
Query: 691 LCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENA 518
C RPY CP G+ C G + ++ HL HK + G N P V+
Sbjct: 152 TCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDINLPGAVD-- 209
Query: 517 TWMLTVFQCFGQYFCLHFEAFQLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLT 341
W++ + CFG +F L E + G + A ++ +G +EA ++ Y LE+ G+ R+LT
Sbjct: 210 -WVM-MQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLT 267
Query: 340 WEGTPRSIRDSHRKVRDSNDGLIIQRNMAFFFS 242
WE PRSI + ++D L+ ++A F+
Sbjct: 268 WEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFA 300
>sp|Q9I8X5|SIAH2_XENLA E3 ubiquitin-protein ligase siah2 OS=Xenopus laevis
GN=siah2 PE=2 SV=1
Length = 313
Score = 150 bits (378), Expect = 3e-035
Identities = 92/263 (34%), Positives = 137/263 (52%), Gaps = 13/263 (4%)
Frame = -1
Query: 1009 SSAAASPTVVTNIVGPTATSVYE---LLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHN 839
+SA +PT I GP + E L ECPVC + PPI QC GH +C+ C+ ++ +
Sbjct: 41 ASAPPAPTAAA-ITGPLSQQHQELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-S 98
Query: 838 RCPTCRQEL-GDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCP 662
CPTCR L IR LA+EKVA ++ PCK+ + GC + K +HE +C +RPY CP
Sbjct: 99 CCPTCRASLTPSIRNLAMEKVASAVLFPCKYASTGCSLSLHHTEKPEHEDICEYRPYSCP 158
Query: 661 YAGSECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCF 488
G+ C G + ++ HL HK + G N P V+ W++ + CF
Sbjct: 159 CPGASCKWQGSLENVMQHLTHSHKSITTLQGEDIVFLATDINLPGAVD---WVMMQY-CF 214
Query: 487 GQYFCLHFEAFQLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRD 311
+F L E + G + A + +G ++A +Y+Y LE+ G+ R+LTWE TPRSI D
Sbjct: 215 NHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENYAYRLELNGNRRRLTWEATPRSIHD 274
Query: 310 SHRKVRDSNDGLIIQRNMAFFFS 242
++D L+ +A F+
Sbjct: 275 GVAAAIMNSDCLVFDTAIAHLFA 297
>sp|P29304|SINA_DROVI E3 ubiquitin-protein ligase sina OS=Drosophila virilis
GN=sina PE=3 SV=1
Length = 314
Score = 149 bits (376), Expect = 5e-035
Identities = 88/265 (33%), Positives = 137/265 (51%), Gaps = 8/265 (3%)
Frame = -1
Query: 1027 SSTKSHSSAAASPTVVTNIVGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVR 848
SS + SS+++S + + + L ECPVC + PPI QC +GH +C +C+ +
Sbjct: 41 SSANTSSSSSSSLSSAGGGDAGMSADLTSLFECPVCFDYVLPPILQCSSGHLVCVSCRSK 100
Query: 847 VHNRCPTCRQELGDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYG 668
+ CPTCR L +IR LA+E+VA +++ PCK GC Y K +HE C RPY
Sbjct: 101 L-TCCPTCRGPLANIRNLAMEEVASNVKFPCKHSGYGCTASLVYTEKTEHEETCECRPYL 159
Query: 667 CPYAGSECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQ 494
CP G+ C G + ++ HL HK + G N P V+ W++ +
Sbjct: 160 CPCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQS 215
Query: 493 CFGQYFCLHFEAFQLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSI 317
CFG +F L E + G + A ++ +G +EA ++ Y LE+ G+ R+LTWE PRSI
Sbjct: 216 CFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLTWEAMPRSI 275
Query: 316 RDSHRKVRDSNDGLIIQRNMAFFFS 242
+ ++D L+ ++A F+
Sbjct: 276 HEGVASAIHNSDCLVFDTSIAQLFA 300
>sp|O43255|SIAH2_HUMAN E3 ubiquitin-protein ligase SIAH2 OS=Homo sapiens
GN=SIAH2 PE=1 SV=1
Length = 324
Score = 148 bits (373), Expect = 1e-034
Identities = 87/247 (35%), Positives = 130/247 (52%), Gaps = 9/247 (3%)
Frame = -1
Query: 970 VGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQEL-GDIRCL 794
V P + L ECPVC + PPI QC GH +C+ C+ ++ + CPTCR L IR L
Sbjct: 67 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPTCRGALTPSIRNL 125
Query: 793 ALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLV 614
A+EKVA ++ PCK+ GC + K +HE +C +RPY CP G+ C G + ++
Sbjct: 126 AMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVM 185
Query: 613 SHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAFQLGMG 440
SHL HK + G N P V+ W++ + CFG +F L E + G
Sbjct: 186 SHLMHAHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYEG 241
Query: 439 -PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQR 263
+ A + +G ++A +++Y LE+ G+ R+LTWE TPRSI D ++D L+
Sbjct: 242 HQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDT 301
Query: 262 NMAFFFS 242
+A F+
Sbjct: 302 AIAHLFA 308
>sp|Q06986|SIAH2_MOUSE E3 ubiquitin-protein ligase SIAH2 OS=Mus musculus
GN=Siah2 PE=1 SV=2
Length = 325
Score = 148 bits (373), Expect = 1e-034
Identities = 87/247 (35%), Positives = 130/247 (52%), Gaps = 9/247 (3%)
Frame = -1
Query: 970 VGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQEL-GDIRCL 794
V P + L ECPVC + PPI QC GH +C+ C+ ++ + CPTCR L IR L
Sbjct: 68 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPTCRGALTPSIRNL 126
Query: 793 ALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLV 614
A+EKVA ++ PCK+ GC + K +HE +C +RPY CP G+ C G + ++
Sbjct: 127 AMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVM 186
Query: 613 SHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAFQLGMG 440
SHL HK + G N P V+ W++ + CFG +F L E + G
Sbjct: 187 SHLMHAHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYEG 242
Query: 439 -PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQR 263
+ A + +G ++A +++Y LE+ G+ R+LTWE TPRSI D ++D L+
Sbjct: 243 HQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDT 302
Query: 262 NMAFFFS 242
+A F+
Sbjct: 303 AIAHLFA 309
>sp|Q8R4T2|SIAH2_RAT E3 ubiquitin-protein ligase SIAH2 OS=Rattus norvegicus
GN=Siah2 PE=1 SV=2
Length = 325
Score = 148 bits (373), Expect = 1e-034
Identities = 87/247 (35%), Positives = 130/247 (52%), Gaps = 9/247 (3%)
Frame = -1
Query: 970 VGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQEL-GDIRCL 794
V P + L ECPVC + PPI QC GH +C+ C+ ++ + CPTCR L IR L
Sbjct: 68 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPTCRGALTPSIRNL 126
Query: 793 ALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLV 614
A+EKVA ++ PCK+ GC + K +HE +C +RPY CP G+ C G + ++
Sbjct: 127 AMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVM 186
Query: 613 SHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAFQLGMG 440
SHL HK + G N P V+ W++ + CFG +F L E + G
Sbjct: 187 SHLMHAHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYEG 242
Query: 439 -PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQR 263
+ A + +G ++A +++Y LE+ G+ R+LTWE TPRSI D ++D L+
Sbjct: 243 HQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDT 302
Query: 262 NMAFFFS 242
+A F+
Sbjct: 303 AIAHLFA 309
>sp|Q7SYL3|SIAH2_DANRE E3 ubiquitin-protein ligase Siah2 OS=Danio rerio
GN=siah2l PE=2 SV=2
Length = 331
Score = 148 bits (371), Expect = 2e-034
Identities = 91/260 (35%), Positives = 136/260 (52%), Gaps = 12/260 (4%)
Frame = -1
Query: 1009 SSAAASPTVVTNIVGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCP 830
++A A P P T+ L ECPVC + PPI QC GH +C+ C+ ++ + CP
Sbjct: 66 AAAVALPVAALPGQSPELTA---LFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCP 121
Query: 829 TCRQEL-GDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAG 653
TCR L IR LA+EKVA +L PCK+ + GC + K +HE +C FRPY CP G
Sbjct: 122 TCRGPLTPSIRNLAMEKVASTLPFPCKYSSAGCLLSLHHSEKPEHEEVCEFRPYTCPCPG 181
Query: 652 SECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQY 479
+ C G + ++ HL HK + G N P V+ W++ + CFG +
Sbjct: 182 ASCKWQGSLEEVMPHLMHAHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHH 237
Query: 478 FCLHFEAFQLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHR 302
F L E + G + A + +G ++A +++Y LE+ G+ R+LTWE TPRSI D
Sbjct: 238 FMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVA 297
Query: 301 KVRDSNDGLIIQRNMAFFFS 242
++D L+ ++A F+
Sbjct: 298 AAIMNSDCLVFDTSIAHLFA 317
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,545,185,555
Number of Sequences: 518415
Number of Extensions: 16545185555
Number of Successful Extensions: 102511304
Number of sequences better than 0.0: 0
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