BLASTX 7.6.2
Query= UN04939 /QuerySize=1175
(1174 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q6PUF4|DHI1L_CHICK Hydroxysteroid 11-beta-dehydrogenase 1-lik... 124 2e-027
sp|A4IGM4|DHI1L_XENTR Hydroxysteroid 11-beta-dehydrogenase 1-lik... 121 2e-026
sp|P54554|YQJQ_BACSU Uncharacterized oxidoreductase yqjQ OS=Baci... 115 9e-025
sp|Q6QLL4|DHI1_CAVPO Corticosteroid 11-beta-dehydrogenase isozym... 114 2e-024
sp|Q6PUF3|DHI1L_DANRE Hydroxysteroid 11-beta-dehydrogenase 1-lik... 113 3e-024
sp|Q6P7J1|DHI1A_XENLA Hydroxysteroid 11-beta-dehydrogenase 1-lik... 111 1e-023
sp|Q29608|DHI1_SAISC Corticosteroid 11-beta-dehydrogenase isozym... 109 7e-023
sp|Q7SYS6|DHI1B_XENLA Hydroxysteroid 11-beta-dehydrogenase 1-lik... 108 9e-023
sp|P50172|DHI1_MOUSE Corticosteroid 11-beta-dehydrogenase isozym... 104 2e-021
sp|P28845|DHI1_HUMAN Corticosteroid 11-beta-dehydrogenase isozym... 104 2e-021
sp|P39484|DHG3_BACME Glucose 1-dehydrogenase 3 OS=Bacillus megat... 94 2e-018
sp|P39483|DHG2_BACME Glucose 1-dehydrogenase 2 OS=Bacillus megat... 93 3e-018
sp|Q6Q7D1|DHI1L_BOVIN Hydroxysteroid 11-beta-dehydrogenase 1-lik... 93 3e-018
sp|P39485|DHG4_BACME Glucose 1-dehydrogenase 4 OS=Bacillus megat... 92 5e-018
sp|P10528|DHGA_BACME Glucose 1-dehydrogenase A OS=Bacillus megat... 92 5e-018
sp|Q6Q7D2|DHI1L_MACFA Hydroxysteroid 11-beta-dehydrogenase 1-lik... 91 1e-017
sp|Q9MYP6|DHB14_BOVIN 17-beta-hydroxysteroid dehydrogenase 14 OS... 90 3e-017
sp|P28643|FABG_CUPLA 3-oxoacyl-[acyl-carrier-protein] reductase,... 89 7e-017
sp|P51661|DHI2_MOUSE Corticosteroid 11-beta-dehydrogenase isozym... 87 2e-016
sp|P50233|DHI2_RAT Corticosteroid 11-beta-dehydrogenase isozyme ... 86 6e-016
>sp|Q6PUF4|DHI1L_CHICK Hydroxysteroid 11-beta-dehydrogenase 1-like protein
OS=Gallus gallus GN=HSD11B1L PE=2 SV=1
Length = 287
Score = 124 bits (310), Expect = 2e-027
Identities = 86/263 (32%), Positives = 137/263 (52%), Gaps = 17/263 (6%)
Frame = +3
Query: 138 ENVARKVVLITGASSGIGEHVAYEYAKKGACLVLVARRRDRLEIVAQKSHQLGSGDVLVI 317
E ++ VL+TGAS+GIGE +AY YA GA +VL ARR L+ V +K LG+ V I
Sbjct: 30 EQLSGARVLLTGASAGIGEQMAYHYATFGAEIVLTARREAVLQEVMKKCLTLGAKKVFYI 89
Query: 318 PGDVANINDCKKLIDDTIHHFGKLDHLI-NNAGVFQTILFEDFTQIQDANPIMDINFWGS 494
P D+++ ++ +++ + + G LD+L+ N+ GV ++ ++ +M +NF+
Sbjct: 90 PADMSSPSEPDRVVQFAVQNLGGLDYLVLNHIGVSPFQMWGG--DVEHTRWLMQVNFFSY 147
Query: 495 TYITYFAIPHLRKSKGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVELS---PD 665
+ A+P L K+ G ++V++S IP P + YSA+K AL FF +LR EL+ +
Sbjct: 148 VALATAALPTLEKNHGSVVVVSSLTGKIPTPFTTSYSATKFALDGFFSSLRHELTMQKRN 207
Query: 666 IKITIVFPGVISTDMTTPHFVEKYGSDFFLSESVTKCAKAIFRGIARGETYIEEPSWLK- 842
+ IT+ G+I TD + G F + + A AI RG A + P WL+
Sbjct: 208 VSITLCILGLIDTDAA---LEKTRGKVFIAASPAAEAALAIIRGGAARLRELFYPWWLQP 264
Query: 843 ----WMFLINSVTPEMFDYLVNY 899
W+ L N P + NY
Sbjct: 265 VHGLWVLLPN---PRVLQSFYNY 284
>sp|A4IGM4|DHI1L_XENTR Hydroxysteroid 11-beta-dehydrogenase 1-like protein
OS=Xenopus tropicalis GN=hsd11b1l PE=2 SV=1
Length = 286
Score = 121 bits (301), Expect = 2e-026
Identities = 72/202 (35%), Positives = 115/202 (56%), Gaps = 4/202 (1%)
Frame = +3
Query: 138 ENVARKVVLITGASSGIGEHVAYEYAKKGACLVLVARRRDRLEIVAQKSHQLGSGDVLVI 317
E +A VL+TGAS+GIGE +AY YA+ GA LVL ARR L+ V + +LG+ +V ++
Sbjct: 28 ETLANTRVLVTGASTGIGEEIAYHYARAGAKLVLTARREHALQEVKSRCLELGAKNVFLV 87
Query: 318 PGDVANINDCKKLIDDTIHHFGKLDHLINNAGVFQTILFEDFTQIQDANPIMDINFWGST 497
D+A+ N ++++ + + G LD+L+ N + D + +M++NF
Sbjct: 88 VADMASHNAREQVVAEALSALGGLDYLVLNHIGWTPFKMWD-GDVNHTRWLMEVNFLSYI 146
Query: 498 YITYFAIPHLRKSKGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVELSPD---I 668
++ A+P+L +SKG IIV++S A P+P + Y+ASK AL FF +LR EL+ +
Sbjct: 147 HLATAALPYLTQSKGSIIVLSSLTAKTPIPYTTSYAASKFALEGFFSSLRHELTMQNNPV 206
Query: 669 KITIVFPGVISTDMTTPHFVEK 734
IT+ G+I T +K
Sbjct: 207 SITLCILGLIDTQSAMEKIKDK 228
>sp|P54554|YQJQ_BACSU Uncharacterized oxidoreductase yqjQ OS=Bacillus subtilis
GN=yqjQ PE=3 SV=1
Length = 259
Score = 115 bits (286), Expect = 9e-025
Identities = 78/194 (40%), Positives = 112/194 (57%), Gaps = 11/194 (5%)
Frame = +3
Query: 138 ENVARKVVLITGASSGIGEHVAYEYAKKGACLVLVARRRDRLEIVAQKSHQLGSGDVLVI 317
+++A K + ITGAS G+GE +AY A +GA ++L ARR DRL + +K + SG +
Sbjct: 2 KHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLIEIKRKITEEWSGQCEIF 61
Query: 318 PGDVANINDCKKLIDDTIHHFGKLDHLINNA--GVFQTILFEDFTQIQDANPIMDINFWG 491
P DV + D ++ D G +D LINNA G+F+T+L D T + D + D+N +G
Sbjct: 62 PLDVGRLEDIARVRD----QIGSIDVLINNAGFGIFETVL--DST-LDDMKAMFDVNVFG 114
Query: 492 STYITYFAIPH-LRKSKGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVELS-PD 665
T +P L + KG II I S A I P +S+YSA+K A++ + LR+ELS
Sbjct: 115 LIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVLGYSNALRMELSGTG 174
Query: 666 IKITIVFPGVISTD 707
I +T V PG I TD
Sbjct: 175 IYVTTVNPGPIQTD 188
>sp|Q6QLL4|DHI1_CAVPO Corticosteroid 11-beta-dehydrogenase isozyme 1 OS=Cavia
porcellus GN=HSD11B1 PE=1 SV=3
Length = 300
Score = 114 bits (284), Expect = 2e-024
Identities = 85/272 (31%), Positives = 135/272 (49%), Gaps = 20/272 (7%)
Frame = +3
Query: 54 LTIIFLFLLYPSYLLGKLVIRLYKHLSFENVARKVVLITGASSGIGEHVAYEYAKKGACL 233
LTI+ +FL Y Y + E + K V++TGAS GIG +AY AK GA +
Sbjct: 9 LTILMVFLAYYYYSAN-------EKFRPEMLQGKKVIVTGASKGIGREIAYHLAKMGAHV 61
Query: 234 VLVARRRDRLEIVAQKSHQLGSGDVLVIPGDVANINDCKKLIDDTIHHFGKLDHLINNAG 413
V+ AR ++ L+ V + +LG+ I G + ++ ++ + + + G LD LI N
Sbjct: 62 VVTARSKEALQKVVARCLELGAASAHYIAGSMEDMTFAEEFVAEAGNLMGGLDMLILNHV 121
Query: 414 VFQTILFEDFTQIQDANPIMDINFWGSTYITYFAIPHLRKSKGKIIVITSGAANIPLPLA 593
++ + F +I + M++NF ++ A+P L +S+G I V++S A I PL
Sbjct: 122 LYNRLTF-FHGEIDNVRKSMEVNFHSFVVLSVAAMPMLMQSQGSIAVVSSVAGKITYPLI 180
Query: 594 SVYSASKAALVRFFETLRVEL---SPDIKITIVFPGVISTDMTTPHFVEKYGSDFFLSES 764
+ YSASK AL FF TLR E ++ IT+ G+I T+ K S +L +
Sbjct: 181 APYSASKFALDGFFSTLRSEFLVNKVNVSITLCILGLIDTETAI-----KATSGIYLGPA 235
Query: 765 VTK--CAKAIFRGIA--RGETYIEEPSWLKWM 848
K CA I +G A + E Y W+ ++
Sbjct: 236 SPKEECALEIIKGTALRQDEMYYVGSRWVPYL 267
>sp|Q6PUF3|DHI1L_DANRE Hydroxysteroid 11-beta-dehydrogenase 1-like protein
OS=Danio rerio GN=hsd11b1l PE=2 SV=1
Length = 287
Score = 113 bits (282), Expect = 3e-024
Identities = 70/187 (37%), Positives = 108/187 (57%), Gaps = 6/187 (3%)
Frame = +3
Query: 159 VLITGASSGIGEHVAYEYAKKGACLVLVARRRDRLEIVAQKSHQLGSGDVLVIPGDVANI 338
VL+TGAS+GIGE +AY YA+ GA +V+ ARR + LE V K ++G+ IP D+AN
Sbjct: 36 VLVTGASTGIGEQLAYHYARLGAQIVITARRGNVLEQVVSKCREMGAQKAFYIPADMANP 95
Query: 339 NDCKKLIDDTIHHFGKLDHLI-NNAGVFQTILFEDFTQIQDANPIMDINFWGSTYITYFA 515
+D ++ I G LD+L+ N+ G +++ +Q ++++NF + A
Sbjct: 96 SDADLVVKYAIEQLGGLDYLVLNHIGPSPYQMWDG--DVQHTRWLLEVNFLSYLQMAQKA 153
Query: 516 IPHLRKSKGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVELS---PDIKITIVF 686
+P L KSKG I+V++S I P A Y+++K AL FF L+ EL+ ++ ITI
Sbjct: 154 LPTLEKSKGSIVVVSSLLGKICGPFALPYASTKFALNGFFGGLQNELAMQKSNVSITICI 213
Query: 687 PGVISTD 707
G+I TD
Sbjct: 214 LGLIDTD 220
>sp|Q6P7J1|DHI1A_XENLA Hydroxysteroid 11-beta-dehydrogenase 1-like protein A
OS=Xenopus laevis GN=hsd11b1l-a PE=2 SV=1
Length = 291
Score = 111 bits (277), Expect = 1e-023
Identities = 81/263 (30%), Positives = 137/263 (52%), Gaps = 16/263 (6%)
Frame = +3
Query: 75 LLYPSYLLGKLVIRLYKHLSF--ENVARKVVLITGASSGIGEHVAYEYAKKGACLVLVAR 248
LL S +G Y S E+V K VLITG+S+GIGE +AYE+A+ GA +++ AR
Sbjct: 6 LLLLSLCVGYTAYHFYSSESMNPESVRGKRVLITGSSTGIGEQIAYEFARMGAHIMVTAR 65
Query: 249 RRDRLEIVAQKSHQLGSGDVLVIPGDVANINDCKKLIDDTIHHFGKLDHLINNAGVFQTI 428
R RL+ VA + +LG+ + D+ N+ + + + ++ G LD+L+ N + +
Sbjct: 66 RLQRLQEVANECLKLGAASAHYVASDMGNLTSAQYVAQEAVNKLGGLDYLVLN-HIGGSA 124
Query: 429 LFEDFTQIQDANPIMD---INFWGSTYITYFAIPHLRKSKGKIIVITSGAANIPLPLASV 599
F F D P++ INF +T A+ L++S+G I+V++S + I P +
Sbjct: 125 SFGFFKGEMD--PVVGSIYINFLSYVQLTSAALKALQESQGSIVVMSSMSGRIGAPFTTS 182
Query: 600 YSASKAALVRFFETLRVEL---SPDIKITIVFPGVISTDMTTPHFVEKYGSDFFLSESVT 770
Y ASK AL F+ +LR E + ++ +T+ G I T+ + V+K G+ +S S
Sbjct: 183 YCASKFALEGFYSSLRREFALQNSNMSVTVAVLGYIDTE----NAVKKVGNKVSMSASSK 238
Query: 771 K-CAKAIFRGIARGETYIEEPSW 836
+ CA+ + + + + P W
Sbjct: 239 EDCAREVVKAAVLKQPELFYPYW 261
>sp|Q29608|DHI1_SAISC Corticosteroid 11-beta-dehydrogenase isozyme 1 OS=Saimiri
sciureus GN=HSD11B1 PE=2 SV=3
Length = 291
Score = 109 bits (270), Expect = 7e-023
Identities = 82/268 (30%), Positives = 127/268 (47%), Gaps = 20/268 (7%)
Frame = +3
Query: 54 LTIIFLFLLYPSYLLGKLVIRLYKHLSFENVARKVVLITGASSGIGEHVAYEYAKKGACL 233
L I+ LF+ Y Y Y+ E + K V++TGAS GIG +AY AK GA +
Sbjct: 9 LPILGLFMAYYYY-------SAYEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHV 61
Query: 234 VLVARRRDRLEIVAQKSHQLGSGDVLVIPGDVANINDCKKLIDDTIHHFGKLDHLINNAG 413
V+ AR ++ L+ V +LG+ I G + ++ ++ + G LD LI N
Sbjct: 62 VVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILN-H 120
Query: 414 VFQTILFEDFTQIQDANPIMDINFWGSTYITYFAIPHLRKSKGKIIVITSGAANIPLPLA 593
+ T L I M++NF +T A+P L++S G I++++S A + P+
Sbjct: 121 ITNTSLNFFHDDIHHVRKSMEVNFLSYVVLTVAAMPMLKQSNGSIVIVSSVAGKVAYPMI 180
Query: 594 SVYSASKAALVRFFETLRVEL---SPDIKITIVFPGVISTDMTTPHFVEKYGSDFFLSES 764
S YSASK AL FF ++R E ++ IT+ G+I TD K S ++
Sbjct: 181 SAYSASKFALYGFFSSIRKEYLMSEVNVSITLCVLGLIDTDTAM-----KAVSGIIKMQA 235
Query: 765 VTK--CAKAIFRG--IARGETYIEEPSW 836
K CA I +G + + E Y + W
Sbjct: 236 ARKEECALEIIKGGVLRQEEVYYDRSLW 263
>sp|Q7SYS6|DHI1B_XENLA Hydroxysteroid 11-beta-dehydrogenase 1-like protein B
OS=Xenopus laevis GN=hsd11b1l-b PE=2 SV=1
Length = 291
Score = 108 bits (269), Expect = 9e-023
Identities = 77/267 (28%), Positives = 139/267 (52%), Gaps = 20/267 (7%)
Frame = +3
Query: 69 LFLLYPSYLLGKLVIRLYK--HLSFENVARKVVLITGASSGIGEHVAYEYAKKGACLVLV 242
+ LL S +G + ++ ++ E+V K VLITG+S+G+GE +AYE+A+ GA +++
Sbjct: 4 VILLLLSLCVGYIAYYFFRTESMNKESVRGKRVLITGSSTGLGEQIAYEFARMGAHIMIT 63
Query: 243 ARRRDRLEIVAQKSHQLGSGDVLVIPGDVANINDCKKLIDDTIHHFGKLDHLINN--AGV 416
ARR +L+ VA + +LG+ + D+ N+ + + + + G LD+L+ N G
Sbjct: 64 ARRLQQLQEVASQCMKLGAASAHYVASDMGNLESAQSVAQEAVVKLGGLDYLVLNHIGGS 123
Query: 417 FQTILFEDFTQIQDANPIM---DINFWGSTYITYFAIPHLRKSKGKIIVITSGAANIPLP 587
F+ D +P++ +NF +T A+ L++S+G I+VI+S + I P
Sbjct: 124 GGFGFFKG-----DMDPVVGSTTVNFLSYVQLTSSALSALQESQGSIVVISSMSGRIGAP 178
Query: 588 LASVYSASKAALVRFFETLRVEL---SPDIKITIVFPGVISTDMTTPHFVEKYGSDFFLS 758
+ Y ASK AL F+ +LR E + + +T+ G I T+ + V+K G+ ++
Sbjct: 179 FTTSYCASKFALEGFYSSLRREFALQNSKMSVTVAVLGYIDTE----NAVKKVGNKVSMT 234
Query: 759 ESVTK-CAKAIFRGIARGETYIEEPSW 836
S + CA+ + + + I P W
Sbjct: 235 ASSKEDCAREVVKAAVLQQPEIFYPYW 261
>sp|P50172|DHI1_MOUSE Corticosteroid 11-beta-dehydrogenase isozyme 1 OS=Mus
musculus GN=Hsd11b1 PE=1 SV=3
Length = 292
Score = 104 bits (258), Expect = 2e-021
Identities = 85/259 (32%), Positives = 129/259 (49%), Gaps = 16/259 (6%)
Frame = +3
Query: 87 SYLLGKLVIRL-YKHLSF------ENVARKVVLITGASSGIGEHVAYEYAKKGACLVLVA 245
+YLL LV+ L Y + S E + K V++TGAS GIG +AY +K GA +VL A
Sbjct: 6 NYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTA 65
Query: 246 RRRDRLEIVAQKSHQLGSGDVLVIPGDVANINDCKKLIDDTIHHFGKLDHLINNAGVFQT 425
R + L+ V + +LG+ I G + ++ ++ I G LD LI N + QT
Sbjct: 66 RSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILN-HITQT 124
Query: 426 ILFEDFTQIQDANPIMDINFWGSTYITYFAIPHLRKSKGKIIVITSGAANIPLPLASVYS 605
L I +M++NF ++ A+P L++S G I VI+S A + P+ + YS
Sbjct: 125 SLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYS 184
Query: 606 ASKAALVRFFETLRVEL---SPDIKITIVFPGVISTDMTTPHFVEKYGSDFFLSESVTKC 776
ASK AL FF T+R EL ++ IT+ G+I T+ E G + +C
Sbjct: 185 ASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETA---MKEISGIINAQASPKEEC 241
Query: 777 AKAIFRGIA--RGETYIEE 827
A I +G A + E Y ++
Sbjct: 242 ALEIIKGTALRKSEVYYDK 260
>sp|P28845|DHI1_HUMAN Corticosteroid 11-beta-dehydrogenase isozyme 1 OS=Homo
sapiens GN=HSD11B1 PE=1 SV=3
Length = 292
Score = 104 bits (257), Expect = 2e-021
Identities = 76/239 (31%), Positives = 120/239 (50%), Gaps = 11/239 (4%)
Frame = +3
Query: 138 ENVARKVVLITGASSGIGEHVAYEYAKKGACLVLVARRRDRLEIVAQKSHQLGSGDVLVI 317
E + K V++TGAS GIG +AY AK GA +V+ AR ++ L+ V +LG+ I
Sbjct: 30 EMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYI 89
Query: 318 PGDVANINDCKKLIDDTIHHFGKLDHLINNAGVFQTI-LFEDFTQIQDANPIMDINFWGS 494
G + ++ ++ + G LD LI N ++ LF D I M++NF
Sbjct: 90 AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHD--DIHHVRKSMEVNFLSY 147
Query: 495 TYITYFAIPHLRKSKGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVELS---PD 665
+T A+P L++S G I+V++S A + P+ + YSASK AL FF ++R E S +
Sbjct: 148 VVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVN 207
Query: 666 IKITIVFPGVISTDMTTPHFVEKYGSDFFLSESVTKCAKAIFRG--IARGETYIEEPSW 836
+ IT+ G+I T+ T V G + +CA I +G + + E Y + W
Sbjct: 208 VSITLCVLGLIDTE-TAMKAVS--GIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLW 263
>sp|P39484|DHG3_BACME Glucose 1-dehydrogenase 3 OS=Bacillus megaterium GN=gdhIII
PE=3 SV=1
Length = 261
Score = 94 bits (231), Expect = 2e-018
Identities = 59/202 (29%), Positives = 107/202 (52%), Gaps = 4/202 (1%)
Frame = +3
Query: 135 FENVARKVVLITGASSGIGEHVAYEYAKKGACLVLVARRRDRLEIVAQKSHQLGSGDVLV 314
+ ++ KVV+ITG S+G+G +A + ++ A +V+ + + A+K + G ++
Sbjct: 2 YTDLKDKVVVITGGSTGLGRAMAVRFGQEEAKVVINYYNNEEEALDAKKEVEEAGGQAII 61
Query: 315 IPGDVANINDCKKLIDDTIHHFGKLDHLINNAGVFQTILFEDFTQIQDANPIMDINFWGS 494
+ GDV D L+ I FG LD +INNAGV + + + + + N ++D N G+
Sbjct: 62 VQGDVTKEEDVVNLVQTAIKEFGTLDVMINNAGVENPVPSHELS-LDNWNKVIDTNLTGA 120
Query: 495 TYITYFAIPHLRKS--KGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVELSP-D 665
+ AI + ++ KG +I ++S IP PL Y+ASK + + ETL +E +P
Sbjct: 121 FLGSREAIKYFVENDIKGNVINMSSVHEMIPWPLFVHYAASKGGMKQMTETLALEYAPKG 180
Query: 666 IKITIVFPGVISTDMTTPHFVE 731
I++ + PG ++T + F +
Sbjct: 181 IRVNNIGPGAMNTPINAEKFAD 202
>sp|P39483|DHG2_BACME Glucose 1-dehydrogenase 2 OS=Bacillus megaterium GN=gdhII
PE=3 SV=1
Length = 261
Score = 93 bits (230), Expect = 3e-018
Identities = 57/202 (28%), Positives = 106/202 (52%), Gaps = 4/202 (1%)
Frame = +3
Query: 135 FENVARKVVLITGASSGIGEHVAYEYAKKGACLVLVARRRDRLEIVAQKSHQLGSGDVLV 314
+ ++ KVV++TG S G+G +A + ++ + +V+ R + + +K + G ++
Sbjct: 2 YTDLKDKVVVVTGGSKGLGRAMAVRFGQEQSKVVVNYRSNEEEALEVKKEIEEAGGQAII 61
Query: 315 IPGDVANINDCKKLIDDTIHHFGKLDHLINNAGVFQTILFEDFTQIQDANPIMDINFWGS 494
+ GDV D L++ + FG LD +INNAGV + + + +++ N ++D N G+
Sbjct: 62 VRGDVTKEEDVVNLVETAVKEFGSLDVMINNAGVENPVPSHELS-LENWNQVIDTNLTGA 120
Query: 495 TYITYFAIPHLRKS--KGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVELSP-D 665
+ AI + ++ KG +I ++S IP PL Y+ASK + ETL +E +P
Sbjct: 121 FLGSREAIKYFVENDIKGNVINMSSVHEMIPWPLFVHYAASKGGMKLMTETLALEYAPKG 180
Query: 666 IKITIVFPGVISTDMTTPHFVE 731
I++ + PG I T + F +
Sbjct: 181 IRVNNIGPGAIDTPINAEKFAD 202
>sp|Q6Q7D1|DHI1L_BOVIN Hydroxysteroid 11-beta-dehydrogenase 1-like protein
OS=Bos taurus GN=HSD11B1L PE=2 SV=1
Length = 287
Score = 93 bits (230), Expect = 3e-018
Identities = 59/167 (35%), Positives = 89/167 (53%), Gaps = 3/167 (1%)
Frame = +3
Query: 159 VLITGASSGIGEHVAYEYAKKGACLVLVARRRDRLEIVAQKSHQLGSGDVLVIPGDVANI 338
VL+TG S+GIGE +AY YA+ G+ LVL A L+ V +LG+ V I D+A+
Sbjct: 32 VLLTGVSAGIGEELAYHYARLGSHLVLTAHTEALLQQVVGNCRKLGAPKVFYIAADMASP 91
Query: 339 NDCKKLIDDTIHHFGKLDHLI-NNAGVFQTILFEDFTQIQDANPIMDINFWGSTYITYFA 515
++++ + G LD+L+ N+ G Q +M +NF +T A
Sbjct: 92 EVPERVVQFALDKLGGLDYLVLNHLGAAPA--GTRVRSSQSTRWLMQMNFLSYVQLTSSA 149
Query: 516 IPHLRKSKGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVEL 656
+P L SKG ++V++S +P +S YSA+K AL FF +LR EL
Sbjct: 150 LPSLTDSKGSLVVVSSLLGRVPTSFSSPYSAAKFALDSFFSSLRREL 196
>sp|P39485|DHG4_BACME Glucose 1-dehydrogenase 4 OS=Bacillus megaterium GN=gdhIV
PE=3 SV=1
Length = 261
Score = 92 bits (228), Expect = 5e-018
Identities = 59/202 (29%), Positives = 106/202 (52%), Gaps = 4/202 (1%)
Frame = +3
Query: 135 FENVARKVVLITGASSGIGEHVAYEYAKKGACLVLVARRRDRLEIVAQKSHQLGSGDVLV 314
+ ++ KVV+ITG S+G+G +A + ++ A +V+ + + A+K + G ++
Sbjct: 2 YTDLKDKVVVITGGSTGLGRAMAVRFGQEEAKVVINYYNNEEEALDAKKEVEEAGGQAII 61
Query: 315 IPGDVANINDCKKLIDDTIHHFGKLDHLINNAGVFQTILFEDFTQIQDANPIMDINFWGS 494
+ GDV D L+ I FG LD +INNAGV + + + + + N ++D N G+
Sbjct: 62 VQGDVTKEEDVVNLVQTAIKEFGTLDVMINNAGVENPVPSHELS-LDNWNKVIDTNLTGA 120
Query: 495 TYITYFAIPHLRKS--KGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVELSP-D 665
+ AI + ++ KG +I ++S IP PL Y+ASK + ETL +E +P
Sbjct: 121 FLGSREAIKYFVENDIKGNVINMSSVHEMIPWPLFVHYAASKGGMKLMTETLALEYAPKG 180
Query: 666 IKITIVFPGVISTDMTTPHFVE 731
I++ + PG ++T + F +
Sbjct: 181 IRVNNIGPGAMNTPINAEKFAD 202
>sp|P10528|DHGA_BACME Glucose 1-dehydrogenase A OS=Bacillus megaterium GN=gdhA
PE=3 SV=1
Length = 261
Score = 92 bits (228), Expect = 5e-018
Identities = 59/202 (29%), Positives = 106/202 (52%), Gaps = 4/202 (1%)
Frame = +3
Query: 135 FENVARKVVLITGASSGIGEHVAYEYAKKGACLVLVARRRDRLEIVAQKSHQLGSGDVLV 314
+ ++ KVV+ITG S+G+G +A + ++ A +V+ + + A+K + G ++
Sbjct: 2 YTDLKDKVVVITGGSTGLGRAMAVRFGQEEAKVVINYYNNEEEALDAKKEVEEAGGQAII 61
Query: 315 IPGDVANINDCKKLIDDTIHHFGKLDHLINNAGVFQTILFEDFTQIQDANPIMDINFWGS 494
+ GDV D L+ I FG LD +INNAGV + + + + + N ++D N G+
Sbjct: 62 VQGDVTKEEDVVNLVQTAIKEFGTLDVMINNAGVENPVPSHELS-LDNWNKVIDTNLTGA 120
Query: 495 TYITYFAIPHLRKS--KGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVELSP-D 665
+ AI + ++ KG +I ++S IP PL Y+ASK + ETL +E +P
Sbjct: 121 FLGSREAIKYFVENDIKGNVINMSSVHEMIPWPLFVHYAASKGGMKLMTETLALEYAPKG 180
Query: 666 IKITIVFPGVISTDMTTPHFVE 731
I++ + PG ++T + F +
Sbjct: 181 IRVNNIGPGAMNTPINAEKFAD 202
>sp|Q6Q7D2|DHI1L_MACFA Hydroxysteroid 11-beta-dehydrogenase 1-like protein
OS=Macaca fascicularis GN=HSD11B1L PE=2 SV=1
Length = 287
Score = 91 bits (225), Expect = 1e-017
Identities = 59/175 (33%), Positives = 92/175 (52%), Gaps = 2/175 (1%)
Frame = +3
Query: 159 VLITGASSGIGEHVAYEYAKKGACLVLVARRRDRLEIVAQKSHQLGSGDVLVIPGDVANI 338
VL+TGAS+G+GE +AY YA+ G+ LVL A L+ V +LG+ V I D+A+
Sbjct: 32 VLLTGASAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASP 91
Query: 339 NDCKKLIDDTIHHFGKLDHLINNAGVFQTILFEDFTQIQDANPIMDINFWGSTYITYFAI 518
+ ++ + G LD+L+ N + Q +M +NF +T A+
Sbjct: 92 EAPESVVQFALDKLGGLDYLVLN-HIGGVPAGTRARTPQATRWLMQVNFLSYVQLTSRAL 150
Query: 519 PHLRKSKGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVELS-PDIKITI 680
P L SKG ++V++S +P ++ YSA+K AL FF +LR EL D+ + I
Sbjct: 151 PSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDSFFGSLRRELDVQDVNVAI 205
>sp|Q9MYP6|DHB14_BOVIN 17-beta-hydroxysteroid dehydrogenase 14 OS=Bos taurus
GN=HSD17B14 PE=2 SV=1
Length = 270
Score = 90 bits (221), Expect = 3e-017
Identities = 58/189 (30%), Positives = 98/189 (51%), Gaps = 6/189 (3%)
Frame = +3
Query: 147 ARKVVLITGASSGIGEHVAYEYAKKGACLVLVARRRDRLEIVAQKSHQLGSGDVLVIPGD 326
A KVV++TG GIG + + + GA +V+ + R V ++ G V ++ D
Sbjct: 8 AGKVVIVTGGGRGIGAGIVRAFVESGAQVVICDKDEARGRAVEREL----PGTVFLL-CD 62
Query: 327 VANINDCKKLIDDTIHHFGKLDHLINNAGVFQTILFEDFTQIQDANPIMDINFWGSTYIT 506
V D + L+ +TI FG+LD ++NNAG + + T Q ++++N G+ +T
Sbjct: 63 VTREEDVRTLVSETIRRFGRLDCIVNNAGYHPPPQWPEETSAQGFRQLLELNLLGTYTLT 122
Query: 507 YFAIPHLRKSKGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVELSP-DIKITIV 683
A+PHLRKS+G +I I+S I A Y A+K A+ + L ++ S +++ +
Sbjct: 123 KLALPHLRKSRGNVINISSLVGAIGQSQAVPYVATKGAVTAMTKALALDESQYGVRVNCI 182
Query: 684 FPGVISTDM 710
PG I T +
Sbjct: 183 SPGNIWTPL 191
>sp|P28643|FABG_CUPLA 3-oxoacyl-[acyl-carrier-protein] reductase, chloroplastic
OS=Cuphea lanceolata GN=CLKR27 PE=2 SV=1
Length = 320
Score = 89 bits (218), Expect = 7e-017
Identities = 68/197 (34%), Positives = 104/197 (52%), Gaps = 7/197 (3%)
Frame = +3
Query: 138 ENVARKVVLITGASSGIGEHVAYEYAKKGACLVLV--ARRRDRLEIVAQKSHQLGSGDVL 311
++V VV++TGAS GIG+ +A K G C VLV AR E V+++ G G L
Sbjct: 73 QSVESPVVIVTGASRGIGKAIALSLGKAG-CKVLVNYARSSKEAEEVSKEIEAFG-GQAL 130
Query: 312 VIPGDVANINDCKKLIDDTIHHFGKLDHLINNAGVFQTILFEDFTQIQDANPIMDINFWG 491
GDV+ D + +I + +G +D L+NNAG+ + L + Q ++D+N G
Sbjct: 131 TFGGDVSKEEDVEAMIKTAVDAWGTVDILVNNAGITRDGLLMRMKKSQ-WQEVIDLNLTG 189
Query: 492 STYITYFAIP-HLRKSKGKIIVITSGAANIPLPLASVYSASKAALVRFFETL-RVELSPD 665
T A ++K KG+II I S + + YSA+KA ++ F +T+ R S +
Sbjct: 190 VFLCTQAAAKIMMKKKKGRIINIASVVGLVGNAGQANYSAAKAGVIGFTKTVAREYASRN 249
Query: 666 IKITIVFPGVISTDMTT 716
I + V PG IS+DMT+
Sbjct: 250 INVNAVAPGFISSDMTS 266
>sp|P51661|DHI2_MOUSE Corticosteroid 11-beta-dehydrogenase isozyme 2 OS=Mus
musculus GN=Hsd11b2 PE=2 SV=2
Length = 386
Score = 87 bits (215), Expect = 2e-016
Identities = 58/194 (29%), Positives = 97/194 (50%), Gaps = 5/194 (2%)
Frame = +3
Query: 144 VARKVVLITGASSGIGEHVAYEYAKKGACLVLVARRRDRLEIVAQKSHQLGSGDVLVIPG 323
VA + VLITG +G G+ A + G ++A D A + L S + ++
Sbjct: 80 VATRAVLITGCDTGFGKETAKKLDAMG--FTVLATVLDLNSPGALELRDLCSPRLKLLQM 137
Query: 324 DVANINDCKKLIDDTIHHFGK--LDHLINNAGVFQTILFEDFTQIQDANPIMDINFWGST 497
D+ D ++++ T H L L+NNAG+ + + + + M++NF+G+
Sbjct: 138 DLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGAL 197
Query: 498 YITYFAIPHLRKSKGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVELSP-DIKI 674
+T +P LR S+G+I+ + S A ++P P + Y SKAA+ +T EL P IK+
Sbjct: 198 ELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKV 257
Query: 675 TIVFPGVISTDMTT 716
+I+ PG TD T
Sbjct: 258 SIIKPGCFKTDAVT 271
>sp|P50233|DHI2_RAT Corticosteroid 11-beta-dehydrogenase isozyme 2 OS=Rattus
norvegicus GN=Hsd11b2 PE=1 SV=1
Length = 400
Score = 86 bits (210), Expect = 6e-016
Identities = 59/197 (29%), Positives = 98/197 (49%), Gaps = 11/197 (5%)
Frame = +3
Query: 144 VARKVVLITGASSGIGEHVAYEYAKKG---ACLVLVARRRDRLEIVAQKSHQLGSGDVLV 314
VA + VLITG +G G+ A + G VL LE+ A+ S +L +
Sbjct: 80 VATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNGPGALELRARCSPRL-----KL 134
Query: 315 IPGDVANINDCKKLIDDTIHHFGK--LDHLINNAGVFQTILFEDFTQIQDANPIMDINFW 488
+ D+ D ++++ T H L L+NNAG+ + + + + M++NF+
Sbjct: 135 LQMDLTKPEDISRVLEITKAHTASTGLWGLVNNAGLNMVVADVELSPVVTFRECMEVNFF 194
Query: 489 GSTYITYFAIPHLRKSKGKIIVITSGAANIPLPLASVYSASKAALVRFFETLRVELSP-D 665
G+ +T +P LR S+G+I+ + S A ++P P + Y SKAA+ +T EL P
Sbjct: 195 GALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFSCELLPWG 254
Query: 666 IKITIVFPGVISTDMTT 716
IK++I+ PG T+ T
Sbjct: 255 IKVSIIQPGCFKTEAVT 271
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,113,185,847
Number of Sequences: 518415
Number of Extensions: 22113185847
Number of Successful Extensions: 153311817
Number of sequences better than 0.0: 0
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