BLASTX 7.6.2
Query= UN05594 /QuerySize=1161
(1160 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus ... 166 4e-040
sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo... 165 8e-040
sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gall... 164 1e-039
sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pong... 164 1e-039
sp|Q8VBZ0|DHRSX_MOUSE Dehydrogenase/reductase SDR family member ... 158 7e-038
sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Dani... 157 2e-037
sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member ... 154 1e-036
sp|Q9VLU5|WWOX_DROME WW domain-containing oxidoreductase OS=Dros... 145 6e-034
sp|Q17QU7|DHR13_BOVIN Dehydrogenase/reductase SDR family member ... 130 2e-029
sp|Q6UX07|DHR13_HUMAN Dehydrogenase/reductase SDR family member ... 129 6e-029
sp|Q5SS80|DHR13_MOUSE Dehydrogenase/reductase SDR family member ... 127 2e-028
sp|O74959|YJCD_SCHPO Uncharacterized oxidoreductase C736.13 OS=S... 117 1e-025
sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12 OS=Mus musculus G... 113 3e-024
sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 OS=Bos taurus GN=... 111 1e-023
sp|Q8TC12|RDH11_HUMAN Retinol dehydrogenase 11 OS=Homo sapiens G... 107 1e-022
sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 OS=Homo sapiens G... 107 2e-022
sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13 OS=Homo sapiens G... 107 2e-022
sp|Q9QYF1|RDH11_MOUSE Retinol dehydrogenase 11 OS=Mus musculus G... 106 4e-022
sp|Q8CEE7|RDH13_MOUSE Retinol dehydrogenase 13 OS=Mus musculus G... 103 3e-021
sp|Q9ERI6|RDH14_MOUSE Retinol dehydrogenase 14 OS=Mus musculus G... 72 9e-012
>sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus musculus
GN=Wwox PE=1 SV=1
Length = 414
Score = 166 bits (418), Expect = 4e-040
Identities = 109/307 (35%), Positives = 159/307 (51%), Gaps = 11/307 (3%)
Frame = +1
Query: 91 FGSRSTAEHVTSKSDLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKS 270
+ +TA + D ++TGA SGIG ETA+ A GA +++ R+L A E S
Sbjct: 107 YDGSTTAMEILQGRDFTGKVVLVTGANSGIGFETAKSFALHGAHVILACRNLSRASEAVS 166
Query: 271 RILSEFPDAEIIVMHLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVE 450
RIL E+ A++ M LDL+ L SV+ F + F++ ++ L++L+ NAG +A +++DG+E
Sbjct: 167 RILEEWHKAKVEAMTLDLAVLRSVQHFAEAFKAKNVSLHVLVCNAGTFALPWGLTKDGLE 226
Query: 451 MTFATNYLGHFLLTKLLLKNLIETAALTGVQGRIVNVTSVVHSWFSGYMLQYLADISR-- 624
TF N+LGHF L +LL L ++ R++ V+S H + D+SR
Sbjct: 227 TTFQVNHLGHFYLVQLLQDVLCRSS-----PARVIVVSSESHRFTDINDSSGKLDLSRLS 281
Query: 625 -NNRSYDATRAYALSKLANVLHTIELSRILHKMDANVTANCVHPGIVRTRLTRDREGLIT 801
Y A AY SKL N+L + EL R L VT+N VHPG + R +
Sbjct: 282 PPRSDYWAMLAYNRSKLCNILFSNELHRRL--SPRGVTSNAVHPGNMMYSAIH-RNSWVY 338
Query: 802 DLVFFLTSKLLKSVPQAAATTCYVATSPRLRNVCGKYFSDCNEARTSKLGSCSVKAQRLW 981
L+F L KS+ Q AATT Y A +P L + G YF++C S+ A+ LW
Sbjct: 339 KLLFTLARPFTKSMQQGAATTVYCAVAPELEGLGGMYFNNCCRCLPSEEAQSEETARALW 398
Query: 982 TASELLI 1002
SE LI
Sbjct: 399 ELSERLI 405
>sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo sapiens
GN=WWOX PE=1 SV=1
Length = 414
Score = 165 bits (416), Expect = 8e-040
Identities = 110/307 (35%), Positives = 157/307 (51%), Gaps = 11/307 (3%)
Frame = +1
Query: 91 FGSRSTAEHVTSKSDLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKS 270
+ +TA + D V+TGA SGIG ETA+ A GA +++ R++ A E S
Sbjct: 107 YDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVS 166
Query: 271 RILSEFPDAEIIVMHLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVE 450
RIL E+ A++ M LDL+ L SV+ F + F++ ++PL++L+ NA +A ++++DG+E
Sbjct: 167 RILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLE 226
Query: 451 MTFATNYLGHFLLTKLLLKNLIETAALTGVQGRIVNVTSVVHSWFSGYMLQYLADISR-- 624
TF N+LGHF L +LL L +A R++ V+S H + D SR
Sbjct: 227 TTFQVNHLGHFYLVQLLQDVLCRSA-----PARVIVVSSESHRFTDINDSLGKLDFSRLS 281
Query: 625 -NNRSYDATRAYALSKLANVLHTIELSRILHKMDANVTANCVHPGIVRTRLTRDREGLIT 801
Y A AY SKL N+L + EL R L VT+N VHPG + R +
Sbjct: 282 PTKNDYWAMLAYNRSKLCNILFSNELHRRL--SPRGVTSNAVHPGNMMYS-NIHRSWWVY 338
Query: 802 DLVFFLTSKLLKSVPQAAATTCYVATSPRLRNVCGKYFSDCNEARTSKLGSCSVKAQRLW 981
L+F L KS+ Q AATT Y A P L + G YF++C S A+ LW
Sbjct: 339 TLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLW 398
Query: 982 TASELLI 1002
SE LI
Sbjct: 399 ALSERLI 405
>sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gallus gallus
GN=WWOX PE=2 SV=2
Length = 414
Score = 164 bits (415), Expect = 1e-039
Identities = 112/308 (36%), Positives = 161/308 (52%), Gaps = 13/308 (4%)
Frame = +1
Query: 91 FGSRSTAEHVTSKSDLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKS 270
+ STA + DL +ITGA SGIG ETA+ A GA +++ R++ +
Sbjct: 107 YDGNSTAMEILQGRDLSGKVIIITGANSGIGFETAKSFALHGAYVILACRNMSRGNDAVQ 166
Query: 271 RILSEFPDAEIIVMHLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVE 450
RIL E+ A++ M LDL+SL SV+ F + F+S ++PL+IL+ NA + ++EDG+E
Sbjct: 167 RILEEWHKAKVEAMTLDLASLRSVQNFAEAFKSKNMPLHILVCNAAIFGSSWCLTEDGLE 226
Query: 451 MTFATNYLGHFLLTKLLLKNLIETAALTGVQGRIVNVTSVVHSWF----SGYMLQYLADI 618
TF N+LGHF L +LL E R+V V+S H + S L + + +
Sbjct: 227 STFQVNHLGHFYLVQLL-----EDILRRSSPARVVVVSSESHRFTEIKDSSGKLDF-SLL 280
Query: 619 SRNNRSYDATRAYALSKLANVLHTIELSRILHKMDANVTANCVHPGIVRTRLTRDREGLI 798
S + + Y A AY SKL N+L + EL+R L VT+N VHPG + + R +
Sbjct: 281 SPSKKEYWAMLAYNRSKLCNILFSNELNRRL--SPHGVTSNSVHPGNM-IYSSIHRNWWV 337
Query: 799 TDLVFFLTSKLLKSVPQAAATTCYVATSPRLRNVCGKYFSDCNEARTSKLGSCSVKAQRL 978
L+F L KS+ Q AATT Y AT+ L + G YF++C S + A L
Sbjct: 338 YTLLFTLARPFTKSMQQGAATTVYCATAAELEGLGGMYFNNCCRCLPSAEARNELTAVAL 397
Query: 979 WTASELLI 1002
W SE LI
Sbjct: 398 WELSERLI 405
>sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pongo abelii
GN=WWOX PE=2 SV=1
Length = 414
Score = 164 bits (415), Expect = 1e-039
Identities = 110/307 (35%), Positives = 158/307 (51%), Gaps = 11/307 (3%)
Frame = +1
Query: 91 FGSRSTAEHVTSKSDLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKS 270
+ +TA + D V+TGA SGIG ETA+ A GA +++ R++ A E S
Sbjct: 107 YDGSTTALEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVS 166
Query: 271 RILSEFPDAEIIVMHLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVE 450
RIL E+ A++ + LDL+ L SV+ F + F++ ++PL++L+ NA +A ++++DG+E
Sbjct: 167 RILEEWHKAKVEAVTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLE 226
Query: 451 MTFATNYLGHFLLTKLLLKNLIETAALTGVQGRIVNVTSVVHSWFSGYMLQYLADISR-- 624
TF N+LGHF L +LL L +A R++ V+S H + D SR
Sbjct: 227 TTFQVNHLGHFYLVQLLQDVLCRSA-----PARVIVVSSESHRFTDINDSLGKLDFSRLS 281
Query: 625 -NNRSYDATRAYALSKLANVLHTIELSRILHKMDANVTANCVHPGIVRTRLTRDREGLIT 801
Y A AY SKL NVL + EL R L VT+N VHPG + R +
Sbjct: 282 PTKNDYWAMLAYNRSKLCNVLFSNELHRRL--SPRGVTSNAVHPGNMMYS-NIHRSWWVY 338
Query: 802 DLVFFLTSKLLKSVPQAAATTCYVATSPRLRNVCGKYFSDCNEARTSKLGSCSVKAQRLW 981
L+F L KS+ Q AATT Y A +P L + G YF++C S A+ LW
Sbjct: 339 TLLFTLARPFTKSMQQGAATTVYCAAAPELEGLGGMYFNNCCRCMPSPEAQSEETARTLW 398
Query: 982 TASELLI 1002
SE LI
Sbjct: 399 ALSERLI 405
>sp|Q8VBZ0|DHRSX_MOUSE Dehydrogenase/reductase SDR family member on chromosome X
homolog OS=Mus musculus GN=Dhrsx PE=2 SV=2
Length = 335
Score = 158 bits (399), Expect = 7e-038
Identities = 110/279 (39%), Positives = 147/279 (52%), Gaps = 10/279 (3%)
Frame = +1
Query: 151 AVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKSRILSEFPDAEIIVMHLDLSS 330
A++TGAT+GIG TAR LA+ G +V+ +E S I +E + LDL+S
Sbjct: 46 AIVTGATAGIGRSTARQLARLGMCVVVAGNDEHRGQEVVSSIRAEMGSDRAHFLPLDLAS 105
Query: 331 LASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNYLGHFLLTKLLLKN 510
LASVR F DF++L LPL++L+NNAG A +EDG E N+LGHFLLT LLL
Sbjct: 106 LASVRGFARDFQALGLPLHLLVNNAGVMLEPRAETEDGFERHLGVNFLGHFLLTLLLLPA 165
Query: 511 LIETAALTGVQGRIVNVTSVVHSWFSGYMLQYLADISRNNRSYDATRAYALSKLANVLHT 690
L + A G R+V V S H + G + +AD+ +Y AYA SKLA L
Sbjct: 166 LRASGA-EGRGSRVVTVGSATH--YVGTV--DMADL-HGRHAYSPYAAYAQSKLALALFA 219
Query: 691 IELSRILHKMDANVTANCVHPGIVRTRLTRDREGLITDLVFFLTSKLLKSVPQAAATTCY 870
++L RIL VT+N PG+V T L R ++ FL + KS + A T Y
Sbjct: 220 LQLQRILDARGDPVTSNMADPGVVDTELYRHAGWVLRTAKRFLGWLVFKSPEEGAWTLVY 279
Query: 871 VATSPRLRNVCGKYFSDCNEARTSKLGSCSVK--AQRLW 981
A +P L V G+Y D EA LG+ + +RLW
Sbjct: 280 AAAAPELEGVGGRYLRD--EAEAEPLGTARDQELQRRLW 316
>sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Danio rerio GN=wwox
PE=2 SV=1
Length = 412
Score = 157 bits (395), Expect = 2e-037
Identities = 107/321 (33%), Positives = 163/321 (50%), Gaps = 15/321 (4%)
Frame = +1
Query: 82 PSGFGSRSTAEHVTSKSDLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEE 261
P + + A + DL ++TGA SGIG ETAR A GA +++ R+ A +
Sbjct: 101 PKRYDGNTGALEILHGQDLSDKVIIVTGANSGIGFETARSFALHGAHVILACRNQSRASK 160
Query: 262 TKSRILSEFPDAEIIVMHLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISED 441
S I+ E+ A + V+ LDL+SL SVR+F + F++ LPL++L+ NA + ++ED
Sbjct: 161 AASLIMGEWSKARVEVLPLDLASLRSVRQFAELFKATKLPLHVLVCNAAVCSQPWRLTED 220
Query: 442 GVEMTFATNYLGHFLLTKLLLKNLIETAALTGVQGRIVNVTSVVHSWFSGYMLQYLAD-- 615
G E TF +LGHFLL + LL++++ +A R+V V+S H + +L +
Sbjct: 221 GFESTFQICHLGHFLLVQ-LLQDVLRLSA----PARVVVVSSESHRFTD--LLDSCGNLD 273
Query: 616 ---ISRNNRSYDATRAYALSKLANVLHTIELSRILHKMDANVTANCVHPGIVRTRLTRDR 786
+S ++Y + AY +KL N+L + EL R + N +HPG +
Sbjct: 274 LDLLSPPQKNYWSLLAYNRAKLCNLLFSSELHR--RMSPHGICCNALHPGSMMFTSIHRS 331
Query: 787 EGLITDLVFFLTSKLLKSVPQAAATTCYVATSPRLRNVCGKYFSDCNEARTSKLGSCSVK 966
L+T L+F L KS+ Q AATT Y A +P L + G YF++C S
Sbjct: 332 WWLLT-LLFSLARPFTKSMQQGAATTVYCAVAPELEGIGGMYFNNCFRCLPSPQAQDPAA 390
Query: 967 AQRLWTASELLISPASCTPQL 1029
A LW SE L+ S PQ+
Sbjct: 391 ALSLWELSERLVQERSTPPQV 411
>sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member on chromosome X
OS=Homo sapiens GN=DHRSX PE=2 SV=2
Length = 330
Score = 154 bits (389), Expect = 1e-036
Identities = 99/280 (35%), Positives = 148/280 (52%), Gaps = 6/280 (2%)
Frame = +1
Query: 151 AVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKSRILSEFPDAEIIVMHLDLSS 330
A++TG T GIG TA+ LA+ G ++I + A++ S+I E + ++ ++ DL+S
Sbjct: 46 AIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLAS 105
Query: 331 LASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNYLGHFLLTKLLLKN 510
+ S+R+FV F+ +PL++LINNAG + DG E F NYLGHFLLT LLL
Sbjct: 106 MTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLLDT 165
Query: 511 LIETAALTGVQGRIVNVTSVVHSWFSGYMLQYLADISRNNRSYDATRAYALSKLANVLHT 690
L E+ + G R+V V+S H Y+ + D +++ Y AYA SKLA VL T
Sbjct: 166 LKESGS-PGHSARVVTVSSATH-----YVAELNMDDLQSSACYSPHAAYAQSKLALVLFT 219
Query: 691 IELSRILHKMDANVTANCVHPGIVRTRLTRDREGLITDLVFFLTSKLLKSVPQAAATTCY 870
L R+L ++VTAN V PG+V T + + L L K+ + A T+ Y
Sbjct: 220 YHLQRLLAAEGSHVTANVVDPGVVNTDVYKHVFWATRLAKKLLGWLLFKTPDEGAWTSIY 279
Query: 871 VATSPRLRNVCGKYFSDCNEARTSKLGSCSVKAQRLWTAS 990
A +P L V G Y + E ++ + Q+LW+ S
Sbjct: 280 AAVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKS 319
>sp|Q9VLU5|WWOX_DROME WW domain-containing oxidoreductase OS=Drosophila
melanogaster GN=Wwox PE=2 SV=1
Length = 409
Score = 145 bits (365), Expect = 6e-034
Identities = 112/310 (36%), Positives = 162/310 (52%), Gaps = 17/310 (5%)
Frame = +1
Query: 91 FGSRSTAEHVTSKSDLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKS 270
F S STA V DL TA+ITGA GIG ETAR LA G ++ R+ +AE
Sbjct: 104 FDSCSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIE 163
Query: 271 RILSEFPDA--EIIVMHLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDG 444
RI E P A LDLSSL SV+RFV++ + ++ LI NAG +A + + DG
Sbjct: 164 RIAQERPAARSRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDG 223
Query: 445 VEMTFATNYLGHFLLTKLLLKNLIETAALTGVQGRIVNVTSVVHSWFSGYMLQYLA--DI 618
+E TF ++L HF LT ++ L + RI+ ++S H F+ ++ LA +
Sbjct: 224 LETTFQVSHLSHFYLT-------LQLETLFDYKTRIIVLSSESHR-FANLPVENLAVHHL 275
Query: 619 SRNNRSYDATRAYALSKLANVLHTIELSRILHKMDANVTANCVHPG-IVRTRLTRDREGL 795
S Y + AY +KL NVL EL++ + +V + +HPG +V + L+R+
Sbjct: 276 SPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGISVFS--LHPGNMVSSDLSRNY--W 331
Query: 796 ITDLVFFLTSKLLKSVPQAAATTCYVATSPRLRNVCGKYFSDCNEARTSKLGSCSVKAQR 975
L+F + KS+ QAAAT+ Y AT+ L + G YF++C SKL + Q+
Sbjct: 332 FYRLLFAIVRPFTKSLQQAAATSIYCATANELTGLSGLYFNNCFFCEPSKLSKSAALQQQ 391
Query: 976 LWTASELLIS 1005
LW SE LI+
Sbjct: 392 LWKLSENLIA 401
>sp|Q17QU7|DHR13_BOVIN Dehydrogenase/reductase SDR family member 13 OS=Bos
taurus GN=DHRS13 PE=2 SV=1
Length = 377
Score = 130 bits (326), Expect = 2e-029
Identities = 106/295 (35%), Positives = 141/295 (47%), Gaps = 21/295 (7%)
Frame = +1
Query: 130 SDLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKSRILSEFPDAEIIV 309
+ LR TAV+TGA SGIG TA LA+RGAR+V+ RS + E + E + E+I
Sbjct: 32 ASLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSRERGEAAAFDLRQESGNNEVIF 91
Query: 310 MHLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNYLGHFLL 489
M LDL+SLASVR F F S L+ILI+NAG + + + N++G FLL
Sbjct: 92 MALDLASLASVRAFATAFLSSEPRLDILIHNAG--ISSCGRTREPFNLLLRVNHIGPFLL 149
Query: 490 TKLLLKNLIETAALTGVQGRIVNVTSVVHSWFSGYMLQYLADISRNNRS----YDATRAY 657
T LLL L T R+V V+S H + D +R + RAY
Sbjct: 150 THLLLPRL-----KTSAPSRVVVVSSAAHR-------RGRLDFTRLDHPVVGWQQELRAY 197
Query: 658 ALSKLANVLHTIELSRILHKMDANVTANCVHPGIVRTRL-TRDREGLITDLVFFLTSKLL 834
A SKLANVL EL+ L VT HPG V + L R G + L+ L +L
Sbjct: 198 ANSKLANVLFARELATQLE--GTGVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVL 255
Query: 835 KSVPQAAATTCYVATSPRLRNVCGKYFSDCNEARTSKLGSCSVKAQRLWTASELL 999
++ A T Y A + + G+YF++C+ A RLW AS L
Sbjct: 256 RAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASRKL 310
>sp|Q6UX07|DHR13_HUMAN Dehydrogenase/reductase SDR family member 13 OS=Homo
sapiens GN=DHRS13 PE=1 SV=1
Length = 377
Score = 129 bits (322), Expect = 6e-029
Identities = 106/294 (36%), Positives = 141/294 (47%), Gaps = 21/294 (7%)
Frame = +1
Query: 133 DLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKSRILSEFPDAEIIVM 312
+LR TAV+TGA SGIG TA LA+RGAR+V+ RS + E + E + E+I M
Sbjct: 33 NLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFM 92
Query: 313 HLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNYLGHFLLT 492
LDL+SLASVR F F S L+ILI+NAG + + + N++G FLLT
Sbjct: 93 ALDLASLASVRAFATAFLSSEPRLDILIHNAG--ISSCGRTREAFNLLLRVNHIGPFLLT 150
Query: 493 KLLLKNLIETAALTGVQGRIVNVTSVVHSWFSGYMLQYLADISRNNRSY----DATRAYA 660
LLL L A R+V V S H + D R +R RAYA
Sbjct: 151 HLLLPCLKACA-----PSRVVVVASAAH-------CRGRLDFKRLDRPVVGWRQELRAYA 198
Query: 661 LSKLANVLHTIELSRILHKMDANVTANCVHPGIVRTRL-TRDREGLITDLVFFLTSKLLK 837
+KLANVL EL+ L VT HPG V + L R G + L+ L +L+
Sbjct: 199 DTKLANVLFARELANQLEA--TGVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVLR 256
Query: 838 SVPQAAATTCYVATSPRLRNVCGKYFSDCNEARTSKLGSCSVKAQRLWTASELL 999
+ A T Y A + + G+YF++C+ A RLW AS+ L
Sbjct: 257 APRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASKRL 310
>sp|Q5SS80|DHR13_MOUSE Dehydrogenase/reductase SDR family member 13 OS=Mus
musculus GN=Dhrs13 PE=1 SV=1
Length = 376
Score = 127 bits (317), Expect = 2e-028
Identities = 103/293 (35%), Positives = 142/293 (48%), Gaps = 21/293 (7%)
Frame = +1
Query: 136 LRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKSRILSEFPDAEIIVMH 315
LR T V+TGA SGIG TA LA+RGAR+V+ RS + E + E + E+I M
Sbjct: 34 LRGRTVVVTGANSGIGKMTALELARRGARVVLACRSRERGEAAAFDLRQESGNNEVIFMA 93
Query: 316 LDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNYLGHFLLTK 495
LDL+SLASV+ F F S L++LI+NAG + + + N++G FLLT
Sbjct: 94 LDLASLASVQAFATAFLSSEPRLDVLIHNAG--ISSCGRTRETFNLLLRVNHVGPFLLTH 151
Query: 496 LLLKNLIETAALTGVQGRIVNVTSVVHSWFSGYMLQYLADISRNNRS----YDATRAYAL 663
LLL L A R+V V+S H + D +R + RAYA
Sbjct: 152 LLLPRLRSCA-----PSRVVIVSSAAHR-------RGRLDFTRLDCPVVGWQQELRAYAD 199
Query: 664 SKLANVLHTIELSRILHKMDANVTANCVHPGIVRTRL-TRDREGLITDLVFFLTSKLLKS 840
SKLANVL EL+ L VT HPG V + L R G + ++ L +L++
Sbjct: 200 SKLANVLFARELATQLE--GTGVTCYAAHPGPVNSELFLRHLPGWLRPILRPLAWLVLRA 257
Query: 841 VPQAAATTCYVATSPRLRNVCGKYFSDCNEARTSKLGSCSVKAQRLWTASELL 999
A T Y A + + G+YF++C+ S AQRLW A++ L
Sbjct: 258 PQGGAQTPLYCALQEGIEPLSGRYFANCHVEEVSPAARDDQAAQRLWKATKKL 310
>sp|O74959|YJCD_SCHPO Uncharacterized oxidoreductase C736.13
OS=Schizosaccharomyces pombe GN=SPCC736.13 PE=2 SV=1
Length = 339
Score = 117 bits (293), Expect = 1e-025
Identities = 85/266 (31%), Positives = 138/266 (51%), Gaps = 7/266 (2%)
Frame = +1
Query: 133 DLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKSRILSEFPDAEIIVM 312
DL A++TG++ GIG TA LA++GA++ + R+ + ++ +I E ++I +
Sbjct: 39 DLTGKVALVTGSSGGIGYVTALELARKGAKVYLAGRNEEKYQKVMKQIHDEVRHSKIRFL 98
Query: 313 HLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNYLGHFLLT 492
LDL SV + + F + L+IL+NNAG +++DG E+ TNYL H+L T
Sbjct: 99 RLDLLDFESVYQAAESFIAKEEKLHILVNNAGIMNPPFELTKDGYELQIQTNYLSHYLFT 158
Query: 493 KLLLKNLIETA-ALTGVQGRIVNVTSVVHSWFSGYMLQYLADISRNNRSYDATRAYALSK 669
+LLL L TA RIV+V S+ + + Y Y D++ + Y SK
Sbjct: 159 ELLLPTLRRTAEECRPGDVRIVHVASIAYLQ-APYSGIYFPDLNLPHVLLGTFARYGQSK 217
Query: 670 LANVLHTIELSRILHKMDANVTANCVHPGIVRTRLTRDREGLITDLVFFLTSKLLKSVP- 846
A +L++I L++ L K + + +HPG++RT LTR L+ + L P
Sbjct: 218 YAQILYSIALAKRLEKY--GIYSVSLHPGVIRTELTRYSPTFALKLLEKSVFQYLLLDPI 275
Query: 847 QAAATTCYVATSPRL--RNVCGKYFS 918
+ A T+ Y ATSP + ++ G YF+
Sbjct: 276 RGAMTSLYAATSPEISKEHLNGAYFT 301
>sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12 OS=Mus musculus GN=Rdh12 PE=2
SV=1
Length = 316
Score = 113 bits (281), Expect = 3e-024
Identities = 64/152 (42%), Positives = 91/152 (59%), Gaps = 5/152 (3%)
Frame = +1
Query: 121 TSKSDLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKSRILSEFPDAE 300
T+ + VITGA +GIG ETAR LA+RGAR+ I R + E S I ++ +++
Sbjct: 32 TTNVQIPGKVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIRADTKNSQ 91
Query: 301 IIVMHLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNYLGH 480
++V LDLS S+R F + F + L+ILINNAG ++ + DG E F N+LGH
Sbjct: 92 VLVRKLDLSDTKSIRAFAERFLAEEKKLHILINNAGVMMCPYSKTTDGFETHFGVNHLGH 151
Query: 481 FLLTKLLLKNLIETAALTGVQGRIVNVTSVVH 576
FLLT LLL+ L E+A R+VN++S+ H
Sbjct: 152 FLLTYLLLERLKESA-----PARVVNLSSIAH 178
>sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 OS=Bos taurus GN=RDH12 PE=2
SV=1
Length = 316
Score = 111 bits (277), Expect = 1e-023
Identities = 64/141 (45%), Positives = 87/141 (61%), Gaps = 5/141 (3%)
Frame = +1
Query: 154 VITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKSRILSEFPDAEIIVMHLDLSSL 333
VITGA +GIG ETAR LA+RGAR+ I R + E S I ++ +++++V LDLS
Sbjct: 43 VITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIQADTKNSQVLVRKLDLSDT 102
Query: 334 ASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNYLGHFLLTKLLLKNL 513
S+R F + F + L+ILINNAG ++ + DG E A N+LGHFLLT LLL L
Sbjct: 103 KSIRAFAEGFLAEEKQLHILINNAGVMLCPYSKTADGFETHLAVNHLGHFLLTHLLLGRL 162
Query: 514 IETAALTGVQGRIVNVTSVVH 576
E+A R+VN++SV H
Sbjct: 163 KESA-----PARVVNLSSVAH 178
>sp|Q8TC12|RDH11_HUMAN Retinol dehydrogenase 11 OS=Homo sapiens GN=RDH11 PE=1
SV=2
Length = 318
Score = 107 bits (267), Expect = 1e-022
Identities = 63/152 (41%), Positives = 88/152 (57%), Gaps = 5/152 (3%)
Frame = +1
Query: 121 TSKSDLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKSRILSEFPDAE 300
TS L V+TGA +GIG ETA+ LA+RGAR+ + R ++ E I + + +
Sbjct: 34 TSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQ 93
Query: 301 IIVMHLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNYLGH 480
++V LDLS S+R F F + L++LINNAG ++ + DG EM N+LGH
Sbjct: 94 VLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGH 153
Query: 481 FLLTKLLLKNLIETAALTGVQGRIVNVTSVVH 576
FLLT LLL+ L E+A RIVNV+S+ H
Sbjct: 154 FLLTHLLLEKLKESA-----PSRIVNVSSLAH 180
>sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 OS=Homo sapiens GN=RDH12 PE=1
SV=3
Length = 316
Score = 107 bits (266), Expect = 2e-022
Identities = 63/141 (44%), Positives = 84/141 (59%), Gaps = 5/141 (3%)
Frame = +1
Query: 154 VITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKSRILSEFPDAEIIVMHLDLSSL 333
VITGA +GIG ETAR LA RGAR+ I R + E S I + +++++V LDLS
Sbjct: 43 VITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDT 102
Query: 334 ASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNYLGHFLLTKLLLKNL 513
S+R F + F + L+ILINNAG ++ + DG E N+LGHFLLT LLL+ L
Sbjct: 103 KSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERL 162
Query: 514 IETAALTGVQGRIVNVTSVVH 576
+A R+VNV+SV H
Sbjct: 163 KVSA-----PARVVNVSSVAH 178
>sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1
SV=2
Length = 331
Score = 107 bits (266), Expect = 2e-022
Identities = 60/151 (39%), Positives = 85/151 (56%), Gaps = 5/151 (3%)
Frame = +1
Query: 124 SKSDLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKSRILSEFPDAEI 303
SK+ + T ++TGA +GIG +TA LA+RG +++ R ++ E I E + +
Sbjct: 32 SKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHV 91
Query: 304 IVMHLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNYLGHF 483
HLDL+SL S+R F ++ILINNAG H +EDG EM F N+LGHF
Sbjct: 92 NARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHF 151
Query: 484 LLTKLLLKNLIETAALTGVQGRIVNVTSVVH 576
LLT LLL L +A RI+N++S+ H
Sbjct: 152 LLTNLLLDKLKASA-----PSRIINLSSLAH 177
>sp|Q9QYF1|RDH11_MOUSE Retinol dehydrogenase 11 OS=Mus musculus GN=Rdh11 PE=2
SV=2
Length = 316
Score = 106 bits (263), Expect = 4e-022
Identities = 62/152 (40%), Positives = 89/152 (58%), Gaps = 5/152 (3%)
Frame = +1
Query: 121 TSKSDLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKSRILSEFPDAE 300
TS L A++TGA +GIG ETA+ LA+RGAR+ + R + E I + +++
Sbjct: 31 TSNVQLPGKVAIVTGANTGIGKETAKDLAQRGARVYLACRDVDKGELAAREIQAVTGNSQ 90
Query: 301 IIVMHLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNYLGH 480
+ V LDL+ S+R F DF + L++LINNAG ++ + DG EM N+LGH
Sbjct: 91 VFVRKLDLADTKSIRAFAKDFLAEEKHLHLLINNAGVMMCPYSKTADGFEMHIGVNHLGH 150
Query: 481 FLLTKLLLKNLIETAALTGVQGRIVNVTSVVH 576
FLLT LLL+ L E+A RIVN++S+ H
Sbjct: 151 FLLTHLLLEKLKESA-----PSRIVNLSSLGH 177
>sp|Q8CEE7|RDH13_MOUSE Retinol dehydrogenase 13 OS=Mus musculus GN=Rdh13 PE=2
SV=1
Length = 334
Score = 103 bits (256), Expect = 3e-021
Identities = 59/151 (39%), Positives = 83/151 (54%), Gaps = 5/151 (3%)
Frame = +1
Query: 124 SKSDLRSLTAVITGATSGIGAETARVLAKRGARLVIPARSLKTAEETKSRILSEFPDAEI 303
SK+ + T ++TGA +GIG +TA LAKRG +++ R ++ E I E + +
Sbjct: 32 SKATIPGKTVIVTGANTGIGKQTALELAKRGGNVILACRDMEKCEVAAKDIRGETLNPRV 91
Query: 304 IVMHLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNYLGHF 483
LDL+SL S+R F ++IL+NNA H +EDG EM F NYLGHF
Sbjct: 92 RAERLDLASLKSIREFARKVIKEEERVDILVNNAAVMRCPHWTTEDGFEMQFGVNYLGHF 151
Query: 484 LLTKLLLKNLIETAALTGVQGRIVNVTSVVH 576
LLT LLL L +A RI+N++S+ H
Sbjct: 152 LLTNLLLDKLKASA-----PSRIINLSSLAH 177
>sp|Q9ERI6|RDH14_MOUSE Retinol dehydrogenase 14 OS=Mus musculus GN=Rdh14 PE=1
SV=1
Length = 334
Score = 72 bits (174), Expect = 9e-012
Identities = 42/97 (43%), Positives = 61/97 (62%), Gaps = 5/97 (5%)
Frame = +1
Query: 292 DAEIIVMHLDLSSLASVRRFVDDFESLHLPLNILINNAGKYAHKHAISEDGVEMTFATNY 471
D +++V LDL+SL SVR F + L++LINNAG + + +EDG EM F N+
Sbjct: 104 DGQLVVKELDLASLRSVRAFCQELLQEEPRLDVLINNAGVFHCPYTKTEDGFEMQFGVNH 163
Query: 472 LGHFLLTKLLLKNLIETAALTGVQGRIVNVTSVVHSW 582
LGHFLLT LLL L++++A RIV V+S ++ +
Sbjct: 164 LGHFLLTNLLL-GLLKSSA----PSRIVVVSSKLYKY 195
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,113,185,847
Number of Sequences: 518415
Number of Extensions: 22113185847
Number of Successful Extensions: 153311817
Number of sequences better than 0.0: 0
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