BLASTX 7.6.2
Query= UN05644 /QuerySize=1063
(1062 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54PN3|MED6_DICDI Putative mediator of RNA polymerase II tran... 123 2e-027
sp|O75586|MED6_HUMAN Mediator of RNA polymerase II transcription... 104 1e-021
sp|Q921D4|MED6_MOUSE Mediator of RNA polymerase II transcription... 104 1e-021
sp|Q5RD94|MED6_PONAB Mediator of RNA polymerase II transcription... 104 1e-021
sp|Q3SZY9|MED6_BOVIN Mediator of RNA polymerase II transcription... 104 1e-021
sp|Q7Q107|MED6_ANOGA Mediator of RNA polymerase II transcription... 102 4e-021
sp|Q6IQ63|MED6_DANRE Mediator of RNA polymerase II transcription... 98 1e-019
sp|Q8MSX2|MED6_DROME Mediator of RNA polymerase II transcription... 93 3e-018
sp|Q8SWN5|MED6_ENCCU Mediator of RNA polymerase II transcription... 77 1e-013
sp|Q6CTT6|MED6_KLULA Mediator of RNA polymerase II transcription... 72 5e-012
sp|Q5A2Z1|MED6_CANAL Mediator of RNA polymerase II transcription... 69 7e-011
sp|Q4PHA6|MED6_USTMA Mediator of RNA polymerase II transcription... 66 3e-010
sp|Q6FW12|MED6_CANGA Mediator of RNA polymerase II transcription... 64 1e-009
sp|Q6C3T0|MED6_YARLI Mediator of RNA polymerase II transcription... 64 2e-009
sp|Q75EY3|MED6_ASHGO Mediator of RNA polymerase II transcription... 61 1e-008
sp|Q6BIH7|MED6_DEBHA Mediator of RNA polymerase II transcription... 58 1e-007
sp|A3LQ10|MED6_PICST Mediator of RNA polymerase II transcription... 52 5e-006
>sp|Q54PN3|MED6_DICDI Putative mediator of RNA polymerase II transcription
subunit 6 OS=Dictyostelium discoideum GN=med6 PE=3 SV=1
Length = 267
Score = 123 bits (308), Expect = 2e-027
Identities = 74/217 (34%), Positives = 112/217 (51%), Gaps = 14/217 (6%)
Frame = -1
Query: 990 DTFNGGNAGEQIA----PPLQPPGTDMTGICFRDQLWINSYPLDRNYVFDYFALSPFYDI 823
D+ N N I+ P + D+T + +RD LW+ YPL+ + YF+ S FYD
Sbjct: 40 DSNNNSNLENMISDTSTPRILEEEPDLTQVMWRDPLWLQMYPLNPQTILQYFSYSQFYDK 99
Query: 822 TCNNEVLRRRSVHPLDHSQLSKMTGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYI 643
CNNE L+ + LD S L M GLEY + EP+ F+ KQ R P V YY+
Sbjct: 100 NCNNEQLK---MQRLDLSALKNMDGLEYELIKFVEPSFFLIAKQTRISPTDVLINTLYYV 156
Query: 642 LDGTIYQAPQLCSVFAARVGRAVYHISNAFSVAASKLE------TIKQVDAKSQNEASET 481
++G IYQAP+L VF +RV +++ H+S AF+ +S + +D +Q E S+
Sbjct: 157 INGNIYQAPELHVVFKSRVSQSISHLSEAFNSISSIVNWDIVNGYSLNLDPSNQQEKSKL 216
Query: 480 KPASETVDLKEVKRVDLILKSLYSKLPPAPPPPPFPE 370
S +++ KR+D ++ SL+ K P P P+
Sbjct: 217 AAYSRK-QIEDTKRLDQLINSLFIKFPAINRPVENPQ 252
>sp|O75586|MED6_HUMAN Mediator of RNA polymerase II transcription subunit 6
OS=Homo sapiens GN=MED6 PE=1 SV=2
Length = 246
Score = 104 bits (259), Expect = 1e-021
Identities = 60/132 (45%), Positives = 84/132 (63%), Gaps = 7/132 (5%)
Frame = -1
Query: 927 DMTGICFRDQLWINSYPLDRNYVFDYFA--LSPFYDITCNNEVLRRRSVHPLDHSQLSKM 754
++ GI + D WI L+ V DYF+ +PFYD TCNNEV++ + + L+H L++M
Sbjct: 9 NLLGISWVDSSWIPI--LNSGSVLDYFSERSNPFYDRTCNNEVVKMQRL-TLEH--LNQM 63
Query: 753 TGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTIYQAPQLCSVFAARVGRAV 574
G+EY++ A EP LF+ RKQ+R P +V P+ YYI+ G IYQAP L SV +RV AV
Sbjct: 64 VGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAV 123
Query: 573 YHISNAFSVAAS 538
+ I +AF A S
Sbjct: 124 HGIQSAFDEAMS 135
>sp|Q921D4|MED6_MOUSE Mediator of RNA polymerase II transcription subunit 6
OS=Mus musculus GN=Med6 PE=2 SV=2
Length = 246
Score = 104 bits (259), Expect = 1e-021
Identities = 60/132 (45%), Positives = 84/132 (63%), Gaps = 7/132 (5%)
Frame = -1
Query: 927 DMTGICFRDQLWINSYPLDRNYVFDYFA--LSPFYDITCNNEVLRRRSVHPLDHSQLSKM 754
++ GI + D WI L+ V DYF+ +PFYD TCNNEV++ + + L+H L++M
Sbjct: 9 NLLGISWVDSSWIPI--LNSGSVLDYFSERSNPFYDRTCNNEVVKMQRL-TLEH--LNQM 63
Query: 753 TGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTIYQAPQLCSVFAARVGRAV 574
G+EY++ A EP LF+ RKQ+R P +V P+ YYI+ G IYQAP L SV +RV AV
Sbjct: 64 VGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAV 123
Query: 573 YHISNAFSVAAS 538
+ I +AF A S
Sbjct: 124 HGIQSAFDEAMS 135
>sp|Q5RD94|MED6_PONAB Mediator of RNA polymerase II transcription subunit 6
OS=Pongo abelii GN=MED6 PE=2 SV=1
Length = 246
Score = 104 bits (259), Expect = 1e-021
Identities = 60/132 (45%), Positives = 84/132 (63%), Gaps = 7/132 (5%)
Frame = -1
Query: 927 DMTGICFRDQLWINSYPLDRNYVFDYFA--LSPFYDITCNNEVLRRRSVHPLDHSQLSKM 754
++ GI + D WI L+ V DYF+ +PFYD TCNNEV++ + + L+H L++M
Sbjct: 9 NLLGISWVDSSWIPI--LNSGSVLDYFSERSNPFYDRTCNNEVVKMQRL-TLEH--LNQM 63
Query: 753 TGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTIYQAPQLCSVFAARVGRAV 574
G+EY++ A EP LF+ RKQ+R P +V P+ YYI+ G IYQAP L SV +RV AV
Sbjct: 64 VGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAV 123
Query: 573 YHISNAFSVAAS 538
+ I +AF A S
Sbjct: 124 HGIQSAFDEAMS 135
>sp|Q3SZY9|MED6_BOVIN Mediator of RNA polymerase II transcription subunit 6
OS=Bos taurus GN=MED6 PE=2 SV=1
Length = 246
Score = 104 bits (258), Expect = 1e-021
Identities = 60/132 (45%), Positives = 84/132 (63%), Gaps = 7/132 (5%)
Frame = -1
Query: 927 DMTGICFRDQLWINSYPLDRNYVFDYFA--LSPFYDITCNNEVLRRRSVHPLDHSQLSKM 754
++ GI + D WI L+ V DYF+ +PFYD TCNNEV++ + + L+H L++M
Sbjct: 9 NLLGISWVDSSWIPI--LNSGSVLDYFSERSNPFYDRTCNNEVVKMQRL-TLEH--LNQM 63
Query: 753 TGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTIYQAPQLCSVFAARVGRAV 574
G+EY++ A EP LF+ RKQ+R P +V P+ YYI+ G IYQAP L SV +RV AV
Sbjct: 64 VGVEYILLHAQEPILFIIRKQQRQSPTQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAV 123
Query: 573 YHISNAFSVAAS 538
+ I +AF A S
Sbjct: 124 HGIQSAFDEAMS 135
>sp|Q7Q107|MED6_ANOGA Mediator of RNA polymerase II transcription subunit 6
OS=Anopheles gambiae GN=MED6 PE=3 SV=3
Length = 267
Score = 102 bits (254), Expect = 4e-021
Identities = 58/130 (44%), Positives = 79/130 (60%), Gaps = 11/130 (8%)
Frame = -1
Query: 915 ICFRDQLWINSYPLDRNYVFDYFA--LSPFYDITCNNEVLR--RRSVHPLDHSQLSKMTG 748
I + D WI L+ V DYF+ +PFYD TCNNE++R R+S+ L+ MTG
Sbjct: 19 ISWHDSNWIP--VLNPGNVMDYFSEKSNPFYDRTCNNEIVRMQRQSL-----ELLNNMTG 71
Query: 747 LEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTIYQAPQLCSVFAARVGRAVYH 568
+EY+ +P L+V RKQ R P + TPM YYI+ GT+YQAP L SVF +R+ V+H
Sbjct: 72 VEYIPLHVQDPILYVIRKQHRHSPTEATPMADYYIIAGTVYQAPDLASVFNSRILSTVHH 131
Query: 567 ISNAFSVAAS 538
+ AF A+S
Sbjct: 132 LQTAFDEASS 141
>sp|Q6IQ63|MED6_DANRE Mediator of RNA polymerase II transcription subunit 6
OS=Danio rerio GN=med6 PE=2 SV=1
Length = 254
Score = 98 bits (242), Expect = 1e-019
Identities = 61/160 (38%), Positives = 92/160 (57%), Gaps = 11/160 (6%)
Frame = -1
Query: 927 DMTGICFRDQLWINSYPLDRNYVFDYFA--LSPFYDITCNNEVLRRRSVHPLDHSQLSKM 754
++ GI + D W+ L+ + V +YF+ +PFYD TCNNEV++ + LDH L+++
Sbjct: 9 NLLGISWVDSGWVPI--LNPSNVLEYFSERSNPFYDRTCNNEVVKMQR-STLDH--LTQL 63
Query: 753 TGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTIYQAPQLCSVFAARVGRAV 574
G+EY++ EP L++ RKQ+R P +V P+ YYI+ G +YQAP L SV ++R AV
Sbjct: 64 VGVEYILLHTQEPILYIIRKQQRQSPTQVIPLADYYIIAGVVYQAPDLGSVISSRALSAV 123
Query: 573 YHISNAFSVAAS--KLETIKQV--DAKSQNEASETKPASE 466
+ I +AF A S + K K Q E KP S+
Sbjct: 124 HGIQSAFDEAMSFCRYHPSKGYWWHFKDQEEKERVKPKSK 163
>sp|Q8MSX2|MED6_DROME Mediator of RNA polymerase II transcription subunit 6
OS=Drosophila melanogaster GN=MED6 PE=1 SV=1
Length = 249
Score = 93 bits (230), Expect = 3e-018
Identities = 47/110 (42%), Positives = 66/110 (60%), Gaps = 5/110 (4%)
Frame = -1
Query: 861 VFDYFA--LSPFYDITCNNEVLRRRSVHPLDHSQLSKMTGLEYVISDATEPNLFVFRKQK 688
V DYF +PFYD CNNE +R + + P L M GLEY++ EP L+V RKQ
Sbjct: 29 VMDYFCRKSNPFYDHMCNNETVRMQRLGP---EHLHNMIGLEYILLHVAEPILYVIRKQH 85
Query: 687 RDGPEKVTPMLTYYILDGTIYQAPQLCSVFAARVGRAVYHISNAFSVAAS 538
R P + TP+ YYI+ GT+Y+AP L +V +R+ V ++ +AF A+S
Sbjct: 86 RHNPSEATPIADYYIIGGTVYKAPDLANVINSRILNTVVNLQSAFEEASS 135
>sp|Q8SWN5|MED6_ENCCU Mediator of RNA polymerase II transcription subunit 6
OS=Encephalitozoon cuniculi GN=MED6 PE=3 SV=1
Length = 177
Score = 77 bits (189), Expect = 1e-013
Identities = 46/122 (37%), Positives = 71/122 (58%), Gaps = 4/122 (3%)
Frame = -1
Query: 915 ICFRDQLWINSYPLDRNYVFDYFALSPFYDITCNNEVLRRRS-VHPLDH-SQLSKMTGLE 742
I F DQ ++ S PLD V +YF+ SPFYD +CNNE+L+ ++ LD S+L M G+
Sbjct: 8 ISFVDQRFLGSKPLDDTNVLEYFSGSPFYDKSCNNEILKMQTQFRGLDQKSKLFSMVGIF 67
Query: 741 YVISDAT-EPNLFVFRKQKRDGPEKVTPMLTYYILDGTIYQAPQLCSVFAARVGRAVYHI 565
Y + + E LFV RK G T + YYI+ G +Y AP S++ R+G +++ +
Sbjct: 68 YEVESSNHEKTLFVIRKAYNHGDTAET-LGMYYIIHGHVYAAPTNYSIYRCRMGDSMWQL 126
Query: 564 SN 559
++
Sbjct: 127 NS 128
>sp|Q6CTT6|MED6_KLULA Mediator of RNA polymerase II transcription subunit 6
OS=Kluyveromyces lactis GN=MED6 PE=3 SV=1
Length = 268
Score = 72 bits (176), Expect = 5e-012
Identities = 31/86 (36%), Positives = 52/86 (60%)
Frame = -1
Query: 807 VLRRRSVHPLDHSQLSKMTGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTI 628
+ R VH + +L KM G+EY++ EP+L++ RKQ+RDGP K T + YY++ +
Sbjct: 87 IWERYPVHAMLEKELMKMKGIEYILVLVREPDLWIIRKQQRDGPTKTTTLRDYYVIGSAV 146
Query: 627 YQAPQLCSVFAARVGRAVYHISNAFS 550
YQ+P + + R+ YH+S++ S
Sbjct: 147 YQSPTVYKIIQNRLLSTNYHLSHSLS 172
>sp|Q5A2Z1|MED6_CANAL Mediator of RNA polymerase II transcription subunit 6
OS=Candida albicans GN=MED6 PE=3 SV=1
Length = 263
Score = 69 bits (166), Expect = 7e-011
Identities = 31/79 (39%), Positives = 50/79 (63%)
Frame = -1
Query: 792 SVHPLDHSQLSKMTGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTIYQAPQ 613
S H S+LS+MTG+E+VI+ EP+ ++ RKQKR P+ + YYI+ +YQAP+
Sbjct: 60 SFHQYFQSRLSEMTGIEFVIAYTKEPDFWIIRKQKRQDPQNTVTLQDYYIIGANVYQAPR 119
Query: 612 LCSVFAARVGRAVYHISNA 556
+ V ++R+ +V I N+
Sbjct: 120 IYDVLSSRLLASVLSIKNS 138
>sp|Q4PHA6|MED6_USTMA Mediator of RNA polymerase II transcription subunit 6
OS=Ustilago maydis GN=MED6 PE=3 SV=1
Length = 254
Score = 66 bits (160), Expect = 3e-010
Identities = 29/76 (38%), Positives = 47/76 (61%)
Frame = -1
Query: 777 DHSQLSKMTGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTIYQAPQLCSVF 598
+ +L + TGLE+V+ + EP FV +K+ R P + TP+ YY+++ +IYQAP L S+
Sbjct: 100 EEQELKRFTGLEFVLVHSREPTCFVVQKRWRTSPTETTPLAAYYVINDSIYQAPDLYSIL 159
Query: 597 AARVGRAVYHISNAFS 550
A R+ VY + + S
Sbjct: 160 ATRLQSTVYALRMSLS 175
>sp|Q6FW12|MED6_CANGA Mediator of RNA polymerase II transcription subunit 6
OS=Candida glabrata GN=MED6 PE=3 SV=1
Length = 302
Score = 64 bits (155), Expect = 1e-009
Identities = 27/82 (32%), Positives = 49/82 (59%)
Frame = -1
Query: 807 VLRRRSVHPLDHSQLSKMTGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTI 628
+L + VH +L K+ G+EYV+++ EP+ +V +KQ+R P + P+ TYYI+ +
Sbjct: 93 ILEKYVVHAFLERELMKVRGIEYVLANVREPDFWVIKKQRRTSPTAIEPLQTYYIVGANV 152
Query: 627 YQAPQLCSVFAARVGRAVYHIS 562
YQ+P + + +R+ H+S
Sbjct: 153 YQSPTVFKIVQSRLLACSSHLS 174
>sp|Q6C3T0|MED6_YARLI Mediator of RNA polymerase II transcription subunit 6
OS=Yarrowia lipolytica GN=MED6 PE=3 SV=1
Length = 227
Score = 64 bits (153), Expect = 2e-009
Identities = 25/61 (40%), Positives = 44/61 (72%)
Frame = -1
Query: 768 QLSKMTGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTIYQAPQLCSVFAAR 589
+L KMTG+E+VI+ EP+L+V +KQ R P++ TP+ TY++++ +Y AP + ++ +R
Sbjct: 67 ELQKMTGIEFVITHVREPDLWVIKKQNRLNPQQTTPISTYFVINENVYMAPTVAAIMQSR 126
Query: 588 V 586
V
Sbjct: 127 V 127
>sp|Q75EY3|MED6_ASHGO Mediator of RNA polymerase II transcription subunit 6
OS=Ashbya gossypii GN=MED6 PE=3 SV=1
Length = 235
Score = 61 bits (146), Expect = 1e-008
Identities = 40/114 (35%), Positives = 62/114 (54%), Gaps = 4/114 (3%)
Frame = -1
Query: 798 RRSVHPLDHSQLSKMTGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTIYQA 619
R + L +L+K+ G+EYV++ EP+ +V RKQ+R G ++VT + YYI+ +YQA
Sbjct: 79 RYPAYALLEQELAKLKGIEYVLAHVREPDFWVVRKQRRAG-DRVTALNDYYIIGANVYQA 137
Query: 618 PQLCSVFAARVGRAVYHISNAFSVAASKLETIK--QVDAKSQNEASETKPASET 463
P SV R+ +H+S A A +L + Q A E + +PAS T
Sbjct: 138 PTAYSVVQNRLLSTGFHLSAALG-AIQRLARFQPGQGAAFVPVEQNSVQPASGT 190
>sp|Q6BIH7|MED6_DEBHA Mediator of RNA polymerase II transcription subunit 6
OS=Debaryomyces hansenii GN=MED6 PE=3 SV=2
Length = 257
Score = 58 bits (138), Expect = 1e-007
Identities = 26/75 (34%), Positives = 48/75 (64%)
Frame = -1
Query: 771 SQLSKMTGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTIYQAPQLCSVFAA 592
S+L +MTG+E++I+ + EP+ ++ RKQ R P++V YYI+ IYQAP++ + ++
Sbjct: 67 SKLVEMTGIEFIIAASREPDFWIIRKQTRLSPKQVNIEQDYYIIGANIYQAPKVYDILSS 126
Query: 591 RVGRAVYHISNAFSV 547
R+ +V I + +
Sbjct: 127 RLLSSVLSIKGSMEL 141
>sp|A3LQ10|MED6_PICST Mediator of RNA polymerase II transcription subunit 6
OS=Pichia stipitis GN=MED6 PE=3 SV=2
Length = 263
Score = 52 bits (124), Expect = 5e-006
Identities = 23/74 (31%), Positives = 45/74 (60%)
Frame = -1
Query: 768 QLSKMTGLEYVISDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGTIYQAPQLCSVFAAR 589
+L +MTG+ +VI+ EP+ ++ RKQ + P+ + YYI+ +YQAP++ V ++R
Sbjct: 70 KLREMTGVVFVIAYNREPDFWIIRKQLQLDPQNAVTLQDYYIIGANVYQAPKVYDVLSSR 129
Query: 588 VGRAVYHISNAFSV 547
+ +V + N+ +
Sbjct: 130 LLSSVLQLRNSIDL 143
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,113,185,847
Number of Sequences: 518415
Number of Extensions: 22113185847
Number of Successful Extensions: 153311817
Number of sequences better than 0.0: 0
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