BLASTX 7.6.2
Query= UN05723 /QuerySize=1630
(1629 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q1RJT3|ODP2_RICBR Dihydrolipoyllysine-residue acetyltransfera... 228 1e-058
sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltransfera... 226 6e-058
sp|Q4ULG1|ODP2_RICFE Dihydrolipoyllysine-residue acetyltransfera... 222 8e-057
sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltransfera... 197 3e-049
sp|Q68WK6|ODP2_RICTY Dihydrolipoyllysine-residue acetyltransfera... 148 2e-034
sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltransfera... 135 1e-030
sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransferase... 128 2e-028
sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltransfera... 128 2e-028
sp|Q8BMF4|ODP2_MOUSE Dihydrolipoyllysine-residue acetyltransfera... 123 4e-027
sp|Q8RWN9|OPD22_ARATH Dihydrolipoyllysine-residue acetyltransfer... 121 2e-026
sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltransfera... 121 3e-026
sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransfera... 118 1e-025
sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltransfera... 115 1e-024
sp|P11182|ODB2_HUMAN Lipoamide acyltransferase component of bran... 113 5e-024
sp|Q0WQF7|OPD21_ARATH Dihydrolipoyllysine-residue acetyltransfer... 110 5e-023
sp|P22439|ODPX_BOVIN Pyruvate dehydrogenase protein X component ... 109 8e-023
sp|P12695|ODP2_YEAST Dihydrolipoyllysine-residue acetyltransfera... 109 1e-022
sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X component,... 106 9e-022
sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X component,... 105 1e-021
>sp|Q1RJT3|ODP2_RICBR Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia bellii (strain RML369-C)
GN=pdhC PE=3 SV=1
Length = 418
Score = 228 bits (580), Expect = 1e-058
Identities = 147/421 (34%), Positives = 230/421 (54%), Gaps = 23/421 (5%)
Frame = +1
Query: 157 EIFMPALSSTMTEGKIVSWVKSEGDKLNKGESVVVVESDKADMDVETFYDGYLAAIMVEE 336
++ MPALS TMTEG + W+K EGDK+N GE + +E+DKA M+VE +G LA I++ +
Sbjct: 4 KLLMPALSPTMTEGNLARWLKKEGDKINPGEVIAEIETDKATMEVEAVDEGTLAKIIIPQ 63
Query: 337 GGV-APVGSAIALLAETQDEIADARAKASGGGGGGATSPPSPPPVVVVEDKVSVPPSKVV 513
G PV S IA+L E +E++ + SP + + ++ P V
Sbjct: 64 GSQNVPVNSLIAVLIEEGEELSGIEEFIAKNNSN------SPKKEEISKPAETIAPQNVK 117
Query: 514 SVSASAVHPASEGGKRVVASPYAKKLAKELKVELAGLVGSGPMGRIVAKDVEAAVASAAA 693
+ + + + +V ASP AK+LAK V + + GSGP GRI+ +DV + + A
Sbjct: 118 EENITTA--SDQNNIKVFASPLAKRLAKIQNVRIEEIKGSGPHGRIIKQDVLSHKGGSKA 175
Query: 694 PPVKTEAMTPTAGVELGSVVPFTTMQGAVSRNMLDS-LSVPTFRVGYTINTDALDALYKK 870
K + P E + P ++ +++ +L+S +VP F + N D L + +
Sbjct: 176 LSNKIVSRNP----EEYRLAPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDIRED 231
Query: 871 I-------KSKGVTMTALLAKATALALAKHPVVNSSCRDGNSFVYNASINIAVAVAIDGG 1029
I KS +++ + A A AL + P N+S D YN +++I+VAVAI+ G
Sbjct: 232 INKSFGDDKSAKISVNDFIILAVAKALQEVPNANASWGDDAIRYYN-NVDISVAVAIENG 290
Query: 1030 LITPVLQNADKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVDRFDAIL 1209
L+TP+++NAD+ +I LS + K L+ KAR +L P+E+ G FT+SNLGM+G+ F+AI+
Sbjct: 291 LVTPIIRNADQKNIVDLSSEMKGLIKKARENKLTPEEFQGGGFTISNLGMYGIKNFNAII 350
Query: 1210 PPGTGAIMAVGASQPTVVATKDGRIGMKNQMQVNVTADHRVIYGADLAQFLQTLASIIED 1389
P IM VG+S + K+ +I + M V ++ADHRV+ GA A+FL IE
Sbjct: 351 NPPQSCIMGVGSSSKRAI-VKNDQISIATIMDVTLSADHRVVDGAVGAEFLAAFKRFIES 409
Query: 1390 P 1392
P
Sbjct: 410 P 410
>sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia conorii GN=pdhC PE=3 SV=1
Length = 412
Score = 226 bits (574), Expect = 6e-058
Identities = 151/427 (35%), Positives = 231/427 (54%), Gaps = 38/427 (8%)
Frame = +1
Query: 157 EIFMPALSSTMTEGKIVSWVKSEGDKLNKGESVVVVESDKADMDVETFYDGYLAAIMVEE 336
+I MPALS TMTEG + W+K EGDK+N GE + +E+DKA M+VE +G LA I++ +
Sbjct: 4 KILMPALSPTMTEGNLARWLKKEGDKVNPGEVIAEIETDKATMEVEAVDEGILAKIVIPQ 63
Query: 337 GGV-APVGSAIALLAETQDEIADAR---AKASGGGGGGATSPPSPPP---VVVVEDKVSV 495
PV S IA+L+E +E D AK + T P P + VE++V+V
Sbjct: 64 NSQNVPVNSLIAVLSEEGEEKTDIDAFIAKNNSVSPSPKTDANLPKPHENIANVEEQVTV 123
Query: 496 PPSKVVSVSASAVHPASEGGKRVVASPYAKKLAKELKVELAGLVGSGPMGRIVAKDVEAA 675
V R+ ASP AK+LAK + + GSGP GRIV +D+ +
Sbjct: 124 IKHDV---------------SRIFASPLAKRLAKMRNIRFESVKGSGPHGRIVKQDILSY 168
Query: 676 VASAAAPPVKTEAMTPTAGVELGSVVPFTTMQGAVSRNMLDS-LSVPTFRVGYTINTDAL 852
S A + + E +VP ++ +++ +L+S +VP F + N D L
Sbjct: 169 TPSTAHNKIVSR------NPEEYRLVPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKL 222
Query: 853 -------DALYKKIKSKGVTMTALLAKATALALAKHPVVNSSCRDGNSFVYNASINIAVA 1011
+ + + KS +++ + A A AL + P N+S + YN +++I+VA
Sbjct: 223 LDIREDINKFFSEDKSTRISVNDFIILAVAKALQEVPNANASWGEDAIRYYN-NVDISVA 281
Query: 1012 VAIDGGLITPVLQNADKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVD 1191
VAI+ GL+TP+++NA++ +I LSR+ K L+ KA+ +L P+E+ G FT+SNLGM+G+
Sbjct: 282 VAIENGLVTPIVKNANQKNILELSREMKALIKKAKDNKLTPEEFQGGGFTISNLGMYGIK 341
Query: 1192 RFDAILPPGTGAIMAVGASQPTVVATKDGRIGMKNQMQVNVTADHRVIYGADLAQFLQTL 1371
F+AI+ P IM VGAS + K+ +I + M V ++ADHRV+ GA A+FL
Sbjct: 342 NFNAIINPPQSCIMGVGASAKRAI-VKNDQITIATIMDVTLSADHRVVDGAVGAEFLVAF 400
Query: 1372 ASIIEDP 1392
IE P
Sbjct: 401 KKFIESP 407
>sp|Q4ULG1|ODP2_RICFE Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia felis GN=pdhC PE=3 SV=1
Length = 412
Score = 222 bits (564), Expect = 8e-057
Identities = 148/423 (34%), Positives = 232/423 (54%), Gaps = 38/423 (8%)
Frame = +1
Query: 169 PALSSTMTEGKIVSWVKSEGDKLNKGESVVVVESDKADMDVETFYDGYLAAIMVEEGGV- 345
P LS TMTEG + W+K EGDK+N GE + +E+DKA M+VE +G LA I++ +
Sbjct: 8 PVLSPTMTEGNLARWLKKEGDKVNPGEVIAEIETDKATMEVEAVDEGILAKIVIPQNSQN 67
Query: 346 APVGSAIALLAETQDEIADAR---AKASGGGGGGATSPPSPPP---VVVVEDKVSVPPSK 507
PV S IA+L+E +E D AK + T P P + VE++V+V
Sbjct: 68 VPVNSLIAVLSEEGEEKTDIDAFIAKNNNVSPSPKTDANLPKPHENIAKVEEQVAV---- 123
Query: 508 VVSVSASAVHPASEGGKRVVASPYAKKLAKELKVELAGLVGSGPMGRIVAKDVEAAVASA 687
H AS ++ ASP AK+LAK + L + GSGP GRIV +D+ + S
Sbjct: 124 -------IKHDAS----KIFASPLAKRLAKMGNIRLESVKGSGPHGRIVKQDILSYTPST 172
Query: 688 AAPPVKTEAMTPTAGVELGSVVPFTTMQGAVSRNMLDS-LSVPTFRVGYTINTDAL---- 852
+ + E +VP ++ +++ +L+S +VP F + N D L
Sbjct: 173 VHNKIVSR------NPEEYRLVPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDIR 226
Query: 853 ---DALYKKIKSKGVTMTALLAKATALALAKHPVVNSSCRDGNSFVYNASINIAVAVAID 1023
+ + + KS +++ + A A AL + P N+S + ++ Y+ +++I+VAVAI+
Sbjct: 227 EDINKSFSEDKSTRISVNDFIILAVAKALQELPNANASWGE-DAIRYHNNVDISVAVAIE 285
Query: 1024 GGLITPVLQNADKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVDRFDA 1203
GL+TP+++NA++ +I LSR+ KEL+ KA+ +L P+E+ G FT+SNLGM+G+ F+A
Sbjct: 286 NGLVTPIVKNANQKNIIELSREMKELIKKAKDNKLTPEEFQGGGFTISNLGMYGIKNFNA 345
Query: 1204 ILPPGTGAIMAVGASQPTVVATKDGRIGMKNQMQVNVTADHRVIYGADLAQFLQTLASII 1383
I+ P IM VGAS + K+ ++ + M V ++ADHRV+ GA A+FL I
Sbjct: 346 IINPPQSCIMGVGASAKRAI-VKNDQVTIATIMDVTLSADHRVVDGAVGAEFLAAFKKFI 404
Query: 1384 EDP 1392
E P
Sbjct: 405 ESP 407
>sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia prowazekii GN=pdhC PE=3
SV=1
Length = 408
Score = 197 bits (499), Expect = 3e-049
Identities = 136/412 (33%), Positives = 220/412 (53%), Gaps = 30/412 (7%)
Frame = +1
Query: 184 TMTEGKIVSWVKSEGDKLNKGESVVVVESDKADMDVETFYDGYLAAIMVEEGGV-APVGS 360
TM EG + W+K EGDK+N GE + +E+DKA M+VE+ +G LA I++ + PV S
Sbjct: 13 TMREGNLARWLKKEGDKVNPGEVIAEIETDKATMEVESVDEGILAKIIIPQNSQNVPVNS 72
Query: 361 AIALLAETQDEIADARAKASGGGGGGATSPPSPPPVVVVEDKVSVPPSKVVSVSASAVHP 540
IA+L+E ++ AD + + V + K K + S + V
Sbjct: 73 LIAVLSEEGEDKADIDSFIAQNNS------------VSLSLKTDATLKK-SNDSITNVEG 119
Query: 541 ASEGGKRVVASPYAKKLAKELKVELAGLVGSGPMGRIVAKDVEAAVASAAAPPVKTEAMT 720
++ ASP AK+LAK + L + GSGP GRIV +D+ + +S ++ +
Sbjct: 120 IKHDSNKIFASPLAKRLAKIGDIRLENVQGSGPHGRIVKQDILSYDSSTSSNKIVYR--- 176
Query: 721 PTAGVELGSVVPFTTMQGAVSRNMLDS-LSVPTFRVGYTINTDAL-------DALYKKIK 876
E VP ++ +++ +L+S +VP F + N D L + + + K
Sbjct: 177 ---DTEEYRSVPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDVREDINKSFSEDK 233
Query: 877 SKGVTMTALLAKATALALAKHPVVNSSCRDGNSFVYNASINIAVAVAIDGGLITPVLQNA 1056
+++ + A A AL + P N+S + YN +++I+VAVAI+ G++TP++++A
Sbjct: 234 VTKISVNDFIILAVAKALQEVPNANASWSEDAIRYYN-NVDISVAVAIENGIVTPIVKDA 292
Query: 1057 DKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVDRFDAILPPGTGAIMA 1236
+K +I LSR+ K L+ KA+ +L P E+ G FT+SNLGM+G+ F+AI+ IM
Sbjct: 293 NKKNIIELSREMKTLIKKAKDNKLTPIEFQGGGFTISNLGMYGIKNFNAIINTPQSCIMG 352
Query: 1237 VGASQPTVVATKDGRIGMKNQMQVNVTADHRVIYGADLAQFLQTLASIIEDP 1392
VGAS + K+ +I + M V ++ADHRVI GA A+FL + IE+P
Sbjct: 353 VGASTKRAI-VKNDQIIIATIMDVTLSADHRVIDGAVSAEFLASFKRFIENP 403
>sp|Q68WK6|ODP2_RICTY Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia typhi GN=pdhC PE=3 SV=1
Length = 404
Score = 148 bits (371), Expect = 2e-034
Identities = 101/304 (33%), Positives = 161/304 (52%), Gaps = 20/304 (6%)
Frame = +1
Query: 505 KVVSVSASAVHPASEGGKRVVASPYAKKLAKELKVELAGLVGSGPMGRIVAKDVEAAVAS 684
K + S + V ++ ASP AK+LAK + L + GSGP GRIV +D+ + S
Sbjct: 108 KKANESITNVEVVKHDLSKIFASPLAKRLAKIRNIRLESVQGSGPHGRIVKQDILSYSPS 167
Query: 685 AAAPPVKTEAMTPTAGVELGSVVPFTTMQGAVSRNMLDS-LSVPTFRVGYTINTDAL--- 852
A E VP ++ +++ +L+S +VP F + N D L
Sbjct: 168 TAY----------NRDTEEYRSVPNNNIRQIIAKRLLESKQTVPHFYLSIECNVDKLLDI 217
Query: 853 ----DALYKKIKSKGVTMTALLAKATALALAKHPVVNSSCRDGNSFVYNASINIAVAVAI 1020
+ + + K +++ + A A AL + P N+S + YN +++I+VAVAI
Sbjct: 218 REDINKSFSEDKLTKISVNDFIILAVAKALQEVPNANASWAEDAIRYYN-NVDISVAVAI 276
Query: 1021 DGGLITPVLQNADKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVDRFD 1200
+ G++TP++++A+K +I LS + K L+ KA+ +L P E+ G FT+SNLGM+G+ F+
Sbjct: 277 ENGIVTPIIKDANKKNIIELSHEMKILIKKAKDNKLTPVEFQGGGFTISNLGMYGIKNFN 336
Query: 1201 AILPPGTGAIMAVGASQPTVVATKDGRIGMKNQMQVNVTADHRVIYGADLAQFLQTLASI 1380
AI+ IM VGAS + K+ +I + M V ++ADHRVI GA A+FL +
Sbjct: 337 AIINTPQSCIMGVGASTKRAI-VKNDQIIIATIMDVTLSADHRVIDGAVSAEFLASFKRF 395
Query: 1381 IEDP 1392
IE P
Sbjct: 396 IEHP 399
>sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rhizobium meliloti GN=pdhC PE=3 SV=1
Length = 447
Score = 135 bits (339), Expect = 1e-030
Identities = 79/195 (40%), Positives = 112/195 (57%), Gaps = 12/195 (6%)
Frame = +1
Query: 160 IFMPALSSTMTEGKIVSWVKSEGDKLNKGESVVVVESDKADMDVETFYDGYLAAIMVEEG 339
I MPALS TM EG + W+ EGDK+ G+ + +E+DKA M+VE +G +A I+V G
Sbjct: 5 ITMPALSPTMEEGNLAKWLVKEGDKVKSGDVIAEIETDKATMEVEAVDEGTVAKIVVPAG 64
Query: 340 --GVAPVGSAIALLAETQDEIADARAKASGGGGGGATSPPSPPPVVVVEDKVSVPPSKVV 513
GV V + IA+LA +++ A A+ GG G A + P+P P E + P+
Sbjct: 65 TEGV-KVNALIAVLAAEGEDV----ATAAKGGNGAAGAVPAPKPKETAETAPAAAPAPAA 119
Query: 514 SVSASAVHPASEG-----GKRVVASPYAKKLAKELKVELAGLVGSGPMGRIVAKDVEAAV 678
+ + A PAS GKR+ +SP A++LAKE ++L+ + GSGP GR+V KDVE AV
Sbjct: 120 APAPQAAAPASPAPADGEGKRIFSSPLARRLAKEAGIDLSAIAGSGPHGRVVKKDVETAV 179
Query: 679 ASAAAPPVKTEAMTP 723
+ AA P A P
Sbjct: 180 SGGAAKPAGAPAAAP 194
Score = 107 bits (265), Expect = 4e-022
Identities = 62/169 (36%), Positives = 101/169 (59%), Gaps = 2/169 (1%)
Frame = +1
Query: 886 VTMTALLAKATALALAKHPVVNSSCRDGNSFVYNASINIAVAVAIDGGLITPVLQNADKV 1065
+++ ++ KA ALAL P N S D N V + ++ VAV+I GGLITP+++ A+
Sbjct: 276 LSVNDMVIKALALALRDVPDANVSWTDQN-MVKHKHADVGVAVSIPGGLITPIVRQAELK 334
Query: 1066 DIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVDRFDAILPPGTGAIMAVGA 1245
+ ++S + K+L +A+ ++L+P+EY GT +SN+GM GV F A++ P I+AVGA
Sbjct: 335 SLSAISNEMKDLGKRAKERKLKPEEYQGGTTAVSNMGMMGVKDFAAVVNPPHATILAVGA 394
Query: 1246 SQPTVVATKDGRIGMKNQMQVNVTADHRVIYGADLAQFLQTLASIIEDP 1392
+ VV ++ + + N M V ++ DHR + GA A+ L IE+P
Sbjct: 395 GEDRVV-VRNKEMVIANVMTVTLSTDHRCVDGALGAELLAAFKRYIENP 442
>sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Rattus norvegicus
GN=Dlat PE=1 SV=3
Length = 632
Score = 128 bits (320), Expect = 2e-028
Identities = 85/248 (34%), Positives = 138/248 (55%), Gaps = 11/248 (4%)
Frame = +1
Query: 670 AAVASAAAPPVKTEAMTPTAGVELGSVVPFTTMQGAVSRNMLDS-LSVPTFRVGYTINTD 846
A A+AAAPP A TP AGV + +P + ++ +++ ++ S ++P + + +N
Sbjct: 384 APAAAAAAPPGPRVAPTP-AGVFID--IPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMG 440
Query: 847 AL----DALYKKIKSKG-VTMTALLAKATALALAKHPVVNSSCRDGNSFVYNASINIAVA 1011
+ L K ++ KG +++ + KA+ALA K P NSS D N ++++VA
Sbjct: 441 EVLLVRKELNKMLEGKGKISVNDFIIKASALACLKVPEANSSWMD-TVIRQNHVVDVSVA 499
Query: 1012 VAIDGGLITPVLQNADKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVD 1191
V+ GLITP++ NA + +++ L KAR +LQP E+ GTFT+SNLGMFG+
Sbjct: 500 VSTPAGLITPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNLGMFGIK 559
Query: 1192 RFDAILPPGTGAIMAVGASQPTVV-ATKDGRIGMKNQMQVNVTADHRVIYGADLAQFLQT 1368
F AI+ P I+A+GAS+ ++ A + + + M V ++ DHRV+ GA AQ+L
Sbjct: 560 NFSAIINPPQACILAIGASEDKLIPADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAE 619
Query: 1369 LASIIEDP 1392
+E P
Sbjct: 620 FKKYLEKP 627
>sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Zymomonas mobilis GN=pdhC PE=3 SV=2
Length = 440
Score = 128 bits (320), Expect = 2e-028
Identities = 76/223 (34%), Positives = 132/223 (59%), Gaps = 13/223 (5%)
Frame = +1
Query: 751 VPFTTMQGAVSRNMLDS-LSVPTFRVGYTINTDALDALYKK------IKSKGVTMTALLA 909
+ + M+ ++R + +S ++P + + DAL L + +++ +++ +L
Sbjct: 216 IKLSNMRRVIARRLTESKQNIPHIYLTVDVQMDALLKLRSELNESLAVQNIKISVNDMLI 275
Query: 910 KATALALAKHPVVNSSCRDGNSFVYNASINIAVAVAIDGGLITPVLQNADKVDIYSLSRK 1089
KA ALAL P VN + DG+ + + +I+VAV+++GGLITP+L+ AD + +LS +
Sbjct: 276 KAQALALKATPNVNVAF-DGDQMLQFSQADISVAVSVEGGLITPILKQADTKSLSALSVE 334
Query: 1090 WKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVDRFDAILPPGTGAIMAVGASQ--PTVV 1263
KEL+ +AR +LQPQEY GT ++SN+GMFG+ +F+A++ P +I+A+G+ + P V+
Sbjct: 335 MKELIARAREGRLQPQEYQGGTSSISNMGMFGIKQFNAVINPPQASILAIGSGERRPWVI 394
Query: 1264 ATKDGRIGMKNQMQVNVTADHRVIYGADLAQFLQTLASIIEDP 1392
D I + + + DHRVI GAD A F+ ++E P
Sbjct: 395 ---DDAITIATVATITGSFDHRVIDGADAAAFMSAFKHLVEKP 434
>sp|Q8BMF4|ODP2_MOUSE Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Mus musculus GN=Dlat
PE=1 SV=2
Length = 642
Score = 123 bits (308), Expect = 4e-027
Identities = 83/247 (33%), Positives = 136/247 (55%), Gaps = 11/247 (4%)
Frame = +1
Query: 673 AVASAAAPPVKTEAMTPTAGVELGSVVPFTTMQGAVSRNMLDS-LSVPTFRVGYTINTDA 849
A A+A APP A P AGV + +P + ++ +++ ++ S ++P + + +N
Sbjct: 395 AAAAAMAPPGPRVAPAP-AGV--FTDIPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMGE 451
Query: 850 L----DALYKKIKSKG-VTMTALLAKATALALAKHPVVNSSCRDGNSFVYNASINIAVAV 1014
+ L K ++ KG +++ + KA+ALA K P NSS D N ++++VAV
Sbjct: 452 VLLVRKELNKMLEGKGKISVNDFIIKASALACLKVPEANSSWMD-TVIRQNHVVDVSVAV 510
Query: 1015 AIDGGLITPVLQNADKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVDR 1194
+ GLITP++ NA + +++ L KAR +LQP E+ GTFT+SNLGMFG+
Sbjct: 511 STPAGLITPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNLGMFGIKN 570
Query: 1195 FDAILPPGTGAIMAVGASQPTVV-ATKDGRIGMKNQMQVNVTADHRVIYGADLAQFLQTL 1371
F AI+ P I+A+GAS+ ++ A + + + M V ++ DHRV+ GA AQ+L
Sbjct: 571 FSAIINPPQACILAIGASEDKLIPADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEF 630
Query: 1372 ASIIEDP 1392
+E P
Sbjct: 631 KKYLEKP 637
>sp|Q8RWN9|OPD22_ARATH Dihydrolipoyllysine-residue acetyltransferase component 2
of pyruvate dehydrogenase complex, mitochondrial OS=Arabidopsis
thaliana GN=At3g13930 PE=1 SV=2
Length = 539
Score = 121 bits (302), Expect = 2e-026
Identities = 73/181 (40%), Positives = 104/181 (57%), Gaps = 5/181 (2%)
Frame = +1
Query: 154 REIFMPALSSTMTEGKIVSWVKSEGDKLNKGESVVVVESDKADMDVETFYDGYLAAIMVE 333
+EI MP+LS TMTEG I W+K EGDK+ GE + VE+DKA +++E +G+LA I+ E
Sbjct: 112 QEIGMPSLSPTMTEGNIARWLKKEGDKVAPGEVLCEVETDKATVEMECMEEGFLAKIVKE 171
Query: 334 EGG-VAPVGSAIALLAETQDEIADARAKASGGGGGGATSPPSPPPVVVVEDKVSVPPS-K 507
EG VG IA+ E +D+I + G A P P + E+KV P S
Sbjct: 172 EGAKEIQVGEVIAITVEDEDDIQKFKDYTPSSDTGPAAPEAKPAPSLPKEEKVEKPASAP 231
Query: 508 VVSVSASAVHPASEGGKRVVASPYAKKLAKELKVELAGLVGSGPMGRIVAKDVEAAVASA 687
+S + P+ + R+ ASP A+KLA++ V L+ + G+GP GRIV DVE +AS
Sbjct: 232 EAKISKPSSAPSED---RIFASPLARKLAEDNNVPLSSIKGTGPEGRIVKADVEDFLASG 288
Query: 688 A 690
+
Sbjct: 289 S 289
>sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Schizosaccharomyces
pombe GN=SPCC794.07 PE=2 SV=1
Length = 483
Score = 121 bits (301), Expect = 3e-026
Identities = 82/260 (31%), Positives = 138/260 (53%), Gaps = 14/260 (5%)
Frame = +1
Query: 649 IVAKDVEAAVASAAAPPVK-TEAMTPTAGVELGSVVPFTTMQGAVSRNMLDSLSV-PTFR 822
+ K A A A P +A P +L P + M+ ++ + +S ++ P +
Sbjct: 227 VAPKPSNEAAAKATTPAASAADAAAPGDYEDL----PLSNMRKIIASRLAESKNMNPHYY 282
Query: 823 VGYTINTDALDALYKKIKSKG-----VTMTALLAKATALALAKHPVVNSSCRDGNSFVYN 987
V ++N + + L + + +++ L+ KAT AL + P VN++ G+
Sbjct: 283 VTVSVNMEKIIRLRAALNAMADGRYKLSVNDLVIKATTAALRQVPEVNAAWM-GDFIRQY 341
Query: 988 ASINIAVAVAIDGGLITPVLQNADKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLS 1167
+++I++AVA GLITPV++N + + +S K+ +AR +L+P+EY GTFT+S
Sbjct: 342 KNVDISMAVATPSGLITPVIRNTHALGLAEISTLAKDYGQRARNNKLKPEEYQGGTFTIS 401
Query: 1168 NLGMFGVDRFDAILPPGTGAIMAVGASQPTVVATKDGRIGMKNQ--MQVNVTADHRVIYG 1341
NLGMF VD+F AI+ P I+AVG + TVV G K M+ +++DHRV+ G
Sbjct: 402 NLGMFPVDQFTAIINPPQACILAVGTTVDTVVPDSTSEKGFKVAPIMKCTLSSDHRVVDG 461
Query: 1342 ADLAQFLQTLASIIEDPKDL 1401
A A+F L I+E+P ++
Sbjct: 462 AMAARFTTALKKILENPLEI 481
>sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens GN=DLAT
PE=1 SV=3
Length = 647
Score = 118 bits (295), Expect = 1e-025
Identities = 77/249 (30%), Positives = 131/249 (52%), Gaps = 9/249 (3%)
Frame = +1
Query: 667 EAAVASAAAPPVKTEAMTPTAGVELGSVVPFTTMQGAVSRNMLDS-LSVPTFRVGYTINT 843
+ A A AA P M P + + +P + ++ +++ ++ S ++P + + +N
Sbjct: 396 KVAPAPAAVVPPTGPGMAPVP-TGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNM 454
Query: 844 DALDALYKKIKS-----KGVTMTALLAKATALALAKHPVVNSSCRDGNSFVYNASINIAV 1008
+ + K++ +++ + KA+ALA K P NSS D N ++++V
Sbjct: 455 GEVLLVRKELNKILEGRSKISVNDFIIKASALACLKVPEANSSWMD-TVIRQNHVVDVSV 513
Query: 1009 AVAIDGGLITPVLQNADKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGV 1188
AV+ GLITP++ NA + +++ L KAR +LQP E+ GTFT+SNLGMFG+
Sbjct: 514 AVSTPAGLITPIVFNAHIKGVETIANDVVSLATKAREGKLQPHEFQGGTFTISNLGMFGI 573
Query: 1189 DRFDAILPPGTGAIMAVGASQPTVV-ATKDGRIGMKNQMQVNVTADHRVIYGADLAQFLQ 1365
F AI+ P I+A+GAS+ +V A + + + M V ++ DHRV+ GA AQ+L
Sbjct: 574 KNFSAIINPPQACILAIGASEDKLVPADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLA 633
Query: 1366 TLASIIEDP 1392
+E P
Sbjct: 634 EFRKYLEKP 642
>sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Dictyostelium
discoideum GN=pdhC PE=1 SV=2
Length = 635
Score = 115 bits (287), Expect = 1e-024
Identities = 74/231 (32%), Positives = 129/231 (55%), Gaps = 8/231 (3%)
Frame = +1
Query: 718 TPTAGVELGSVVPFTTMQGAVSRNMLDS-LSVPTFRVGYTINTDALDALYKKIKSKG--- 885
TPT+ E + +P + ++ + + +S ++P + + D L L ++ +
Sbjct: 402 TPTSSGEF-TDIPHSNIRKVTAARLTESKQTIPHYYLTMECRVDKLLKLRSELNAMNTVK 460
Query: 886 VTMTALLAKATALALAKHPVVNSSCRDGNSFVYNASINIAVAVAIDGGLITPVLQNADKV 1065
+++ + KA+A AL +PVVNS+ D Y+ +I+I VAV GL TP+++ D
Sbjct: 461 ISVNDFIVKASAAALRDNPVVNSTWTDQFIRRYH-NIDINVAVNTPQGLFTPIVRGVDMK 519
Query: 1066 DIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVDRFDAILPPGTGAIMAVGA 1245
+ S+S K+L +KA+ +L P E+ +GTFT+SNLGM G+ +F A++ P AI+AVG
Sbjct: 520 GLNSISTSVKQLAEKAQNGKLHPSEFESGTFTISNLGMLGIKQFAAVINPPQAAILAVGT 579
Query: 1246 SQPTVVATK--DGRIGMKNQMQVNVTADHRVIYGADLAQFLQTLASIIEDP 1392
++ VV + D + V ++ DHRVI GA A++L++ +E+P
Sbjct: 580 TETRVVLSNKPDSPYETATILSVTLSCDHRVIDGAVGAEWLKSFKDYVENP 630
>sp|P11182|ODB2_HUMAN Lipoamide acyltransferase component of branched-chain
alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens
GN=DBT PE=1 SV=3
Length = 482
Score = 113 bits (281), Expect = 5e-024
Identities = 86/307 (28%), Positives = 148/307 (48%), Gaps = 27/307 (8%)
Frame = +1
Query: 553 GKRVVASPYAKKLAKELKVELAGLVGSGPMGRIVAKDV----EAAVASAAAPPVKTEAMT 720
G++ +A+P ++LA E ++L+ +VGSG GRI+ +D+ E + P K E M
Sbjct: 168 GRKTLATPAVRRLAMENNIKLSEVVGSGKDGRILKEDILNYLEKQTGAILPPSPKVEIMP 227
Query: 721 P-------TAGVELGSVVPFT---------TMQGAVSRNMLDSLSVPTFRVGYTINTDAL 852
P T + + FT Q A+ + M +L +P F I+ L
Sbjct: 228 PPPKPKDMTVPILVSKPPVFTGKDKTEPIKGFQKAMVKTMSAALKIPHFGYCDEIDLTEL 287
Query: 853 DALYKKIK----SKGVTMTAL--LAKATALALAKHPVVNSSCRDG-NSFVYNASINIAVA 1011
L +++K ++G+ ++ + KA +L L + P++N+S + + Y AS NI +A
Sbjct: 288 VKLREELKPIAFARGIKLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASHNIGIA 347
Query: 1012 VAIDGGLITPVLQNADKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVD 1191
+ + GLI P ++N I+ ++ + L QL + GTFTLSN+G G
Sbjct: 348 MDTEQGLIVPNVKNVQICSIFDIATELNRLQKLGSVGQLSTTDLTGGTFTLSNIGSIGGT 407
Query: 1192 RFDAILPPGTGAIMAVGASQPTVVATKDGRIGMKNQMQVNVTADHRVIYGADLAQFLQTL 1371
++ P AI A+G+ + + G + M V+ +ADHRVI GA +++F
Sbjct: 408 FAKPVIMPPEVAIGALGSIKAIPRFNQKGEVYKAQIMNVSWSADHRVIDGATMSRFSNLW 467
Query: 1372 ASIIEDP 1392
S +E+P
Sbjct: 468 KSYLENP 474
>sp|Q0WQF7|OPD21_ARATH Dihydrolipoyllysine-residue acetyltransferase component 1
of pyruvate dehydrogenase complex, mitochondrial OS=Arabidopsis
thaliana GN=LTA3 PE=1 SV=2
Length = 637
Score = 110 bits (273), Expect = 5e-023
Identities = 75/225 (33%), Positives = 125/225 (55%), Gaps = 9/225 (4%)
Frame = +1
Query: 754 PFTTMQGAVSRNMLDS-LSVPTFRVGYTINTDALDALYKKIKSK---GVTMTALLAKATA 921
P + ++ +++ +L+S +P + + D L A K+++ V++ ++ KA A
Sbjct: 411 PNSQIRKIIAKRLLESKQKIPHLYLQSDVVLDPLLAFRKELQENHGVKVSVNDIVIKAVA 470
Query: 922 LALAKHPVVNSSC-RDGNSFVYNASINIAVAVAIDGGLITPVLQNADKVDIYSLSRKWKE 1098
+AL N+ + V S++I++AVA + GL+TP+++NAD+ I ++S + KE
Sbjct: 471 VALRNVRQANAFWDAEKGDIVMCDSVDISIAVATEKGLMTPIIKNADQKSISAISLEVKE 530
Query: 1099 LVDKARAKQLQPQEYNTGTFTLSNLGMFGVDRFDAILPPGTGAIMAVGASQPTV--VATK 1272
L KAR+ +L P E+ GTF++SNLGM+ VD F AI+ P I+AVG V V
Sbjct: 531 LAQKARSGKLAPHEFQGGTFSISNLGMYPVDNFCAIINPPQAGILAVGRGNKVVEPVIGL 590
Query: 1273 DG--RIGMKNQMQVNVTADHRVIYGADLAQFLQTLASIIEDPKDL 1401
DG + + +M V ++ADHR+ G A F+ L S ED + L
Sbjct: 591 DGIEKPSVVTKMNVTLSADHRIFDGQVGASFMSELRSNFEDVRRL 635
>sp|P22439|ODPX_BOVIN Pyruvate dehydrogenase protein X component OS=Bos taurus
GN=PDHX PE=1 SV=3
Length = 501
Score = 109 bits (271), Expect = 8e-023
Identities = 75/242 (30%), Positives = 128/242 (52%), Gaps = 14/242 (5%)
Frame = +1
Query: 694 PPVKTEAMTPTAGVELGSVVPFTTMQGAVSRNMLDSLSVPTFRVGYTINTDALDALYKKI 873
PPV T G + +P + ++ +++ + +S S T Y L A+
Sbjct: 261 PPVSTPGQPNVEGT--FTEIPASNIRRVIAKRLTESKS--TIPHAYATTDCDLGAVLTAR 316
Query: 874 KSK-----GVTMTALLAKATALALAKHPVVNSSCRDGNSFVYNASINIAVAVAIDGGLIT 1038
++ V++ + KA A+ L + P VN+S DG SI+I+VAVA D GLIT
Sbjct: 317 QNLVRDDIKVSVNDFIIKAAAVTLKQMPNVNASW-DGEGAKQLPSIDISVAVATDRGLIT 375
Query: 1039 PVLQNADKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVDRFDAILPPG 1218
PV+++A + ++ K L KAR +L P+EY G+F++SNLGMFG+D F A++ P
Sbjct: 376 PVIKDAAAKGLQEIADSVKALSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFTAVINPP 435
Query: 1219 TGAIMAVGASQPTVVATKD----GRIGMKNQMQVNVTADHRVIYGADLAQFLQTLASIIE 1386
I+AVG +P + T+D ++ + + V +++D RV+ +FL++ + +E
Sbjct: 436 QACILAVGRFRPVLKLTQDEEGNAQLQQRQLITVTMSSDSRVVDDELATRFLESFKANLE 495
Query: 1387 DP 1392
+P
Sbjct: 496 NP 497
>sp|P12695|ODP2_YEAST Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Saccharomyces
cerevisiae GN=PDA2 PE=1 SV=1
Length = 482
Score = 109 bits (270), Expect = 1e-022
Identities = 74/197 (37%), Positives = 102/197 (51%), Gaps = 8/197 (4%)
Frame = +1
Query: 160 IFMPALSSTMTEGKIVSWVKSEGDKLNKGESVVVVESDKADMDVETFYDGYLAAIMVEEG 339
I MPALS TMT+G + +W K EGD+L+ GE + +E+DKA MD E DGYLA I+V EG
Sbjct: 37 IGMPALSPTMTQGNLAAWTKKEGDQLSPGEVIAEIETDKAQMDFEFQEDGYLAKILVPEG 96
Query: 340 GV-APVGSAIALLAETQDEI-ADARAKASGGGGGGATSPPSPPPVVVVEDKVSVP--PSK 507
PV IA+ E + ++ A K G TS + P E K P +K
Sbjct: 97 TKDIPVNKPIAVYVEDKADVPAFKDFKLEDSGSDSKTSTKAQPAEPQAEKKQEAPAEETK 156
Query: 508 VVSVSASAVHPASEGGKRVVASPYAKKLAKELKVELAGLVGSGPMGRIVAKDVEAAVASA 687
+ A A+ G R+ ASP AK +A E + L + G+GP GRI D+E+ + +
Sbjct: 157 TSAPEAKKSDVAAPQG-RIFASPLAKTIALEKGISLKDVHGTGPRGRITKADIESYLEKS 215
Query: 688 AAPPVKTE---AMTPTA 729
+ +T A TP A
Sbjct: 216 SKQSSQTSGAAAATPAA 232
>sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X component, mitochondrial
OS=Mus musculus GN=Pdhx PE=2 SV=1
Length = 501
Score = 106 bits (262), Expect = 9e-022
Identities = 77/245 (31%), Positives = 127/245 (51%), Gaps = 14/245 (5%)
Frame = +1
Query: 694 PPVKTEAMTPTAGVELGSVVPFTTMQGAVSRNMLDSLSVPTFRVGYTINTDALDALYKKI 873
PPV AG + +P + ++ +++ + +S S T Y L A+ K
Sbjct: 261 PPVSIPGQPNAAGT--FTEIPASNIRRVIAKRLTESKS--TVPHAYATADCDLGAVLKVR 316
Query: 874 KSK-----GVTMTALLAKATALALAKHPVVNSSCRDGNSFVYNASINIAVAVAIDGGLIT 1038
+ V++ + +A A+ L + P VN + DG S++I+VAVA D GLIT
Sbjct: 317 RDLVKDDIKVSVNDFIIRAAAVTLKQMPGVNVTW-DGEGPKQLPSVDISVAVATDKGLIT 375
Query: 1039 PVLQNADKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVDRFDAILPPG 1218
P++++A I ++ K L KAR +L P+EY G+F++SNLGMFG+D F A++ P
Sbjct: 376 PIIKDAAAKGIQEIADSVKVLSKKARDGKLMPEEYQGGSFSISNLGMFGIDEFAAVINPP 435
Query: 1219 TGAIMAVGASQPTVVATKD--GRIGMKNQMQVNVT--ADHRVIYGADLAQFLQTLASIIE 1386
I+AVG +P + T+D G ++ + VT +D RV+ +FL+T + +E
Sbjct: 436 QACILAVGRFRPVLKLTEDEEGNPQLQQHQLITVTMSSDSRVVDDELATRFLETFKANLE 495
Query: 1387 DPKDL 1401
+P L
Sbjct: 496 NPMRL 500
>sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X component, mitochondrial
OS=Homo sapiens GN=PDHX PE=1 SV=3
Length = 501
Score = 105 bits (261), Expect = 1e-021
Identities = 74/242 (30%), Positives = 126/242 (52%), Gaps = 14/242 (5%)
Frame = +1
Query: 694 PPVKTEAMTPTAGVELGSVVPFTTMQGAVSRNMLDSLSVPTFRVGYTINTDALDALYKKI 873
PPV T G + +P + ++ +++ + +S S T Y L A+ K
Sbjct: 261 PPVSTPGQPNAVGT--FTEIPASNIRRVIAKRLTESKS--TVPHAYATADCDLGAVLKVR 316
Query: 874 KSK-----GVTMTALLAKATALALAKHPVVNSSCRDGNSFVYNASINIAVAVAIDGGLIT 1038
+ V++ + KA A+ L + P VN S DG I+I+VAVA D GL+T
Sbjct: 317 QDLVKDDIKVSVNDFIIKAAAVTLKQMPDVNVSW-DGEGPKQLPFIDISVAVATDKGLLT 375
Query: 1039 PVLQNADKVDIYSLSRKWKELVDKARAKQLQPQEYNTGTFTLSNLGMFGVDRFDAILPPG 1218
P++++A I ++ K L KAR +L P+EY G+F++SNLGMFG+D F A++ P
Sbjct: 376 PIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFTAVINPP 435
Query: 1219 TGAIMAVGASQPTVVATKD----GRIGMKNQMQVNVTADHRVIYGADLAQFLQTLASIIE 1386
I+AVG +P + T+D ++ + + V +++D RV+ +FL++ + +E
Sbjct: 436 QACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSFKANLE 495
Query: 1387 DP 1392
+P
Sbjct: 496 NP 497
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,623,450,475
Number of Sequences: 518415
Number of Extensions: 22623450475
Number of Successful Extensions: 161738374
Number of sequences better than 0.0: 0
|
