BLASTX 7.6.2
Query= UN07547 /QuerySize=1422
(1421 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8C2P3|DUS1L_MOUSE tRNA-dihydrouridine synthase 1-like OS=Mus... 278 8e-074
sp|Q8K582|DUS1L_RAT tRNA-dihydrouridine synthase 1-like OS=Rattu... 278 8e-074
sp|Q6P1R4|DUS1L_HUMAN tRNA-dihydrouridine synthase 1-like OS=Hom... 278 1e-073
sp|Q9HGN6|DUS1_SCHPO tRNA-dihydrouridine synthase 1 OS=Schizosac... 258 9e-068
sp|P53759|DUS1_YEAST tRNA-dihydrouridine synthase 1 OS=Saccharom... 242 6e-063
sp|O95620|DUS4L_HUMAN tRNA-dihydrouridine synthase 4-like OS=Hom... 173 5e-042
sp|Q32M08|DUS4L_MOUSE tRNA-dihydrouridine synthase 4-like OS=Mus... 167 3e-040
sp|O74553|DUS4_SCHPO tRNA-dihydrouridine synthase 4 OS=Schizosac... 158 1e-037
sp|Q06063|DUS4_YEAST tRNA-dihydrouridine synthase 4 OS=Saccharom... 151 1e-035
sp|Q8EJR8|DUSB_SHEON tRNA-dihydrouridine synthase B OS=Shewanell... 113 5e-024
sp|Q8PP72|DUSB_XANAC tRNA-dihydrouridine synthase B OS=Xanthomon... 112 6e-024
sp|Q9D7B1|DUS2L_MOUSE tRNA-dihydrouridine synthase 2-like OS=Mus... 108 1e-022
sp|Q9NX74|DUS2L_HUMAN tRNA-dihydrouridine synthase 2-like OS=Hom... 105 9e-022
sp|P37567|DUS1_BACSU Probable tRNA-dihydrouridine synthase 1 OS=... 103 4e-021
sp|P0A2R7|DUSB_SALTI tRNA-dihydrouridine synthase B OS=Salmonell... 93 5e-018
sp|P0A2R6|DUSB_SALTY tRNA-dihydrouridine synthase B OS=Salmonell... 93 5e-018
sp|P41504|DUS_RHILP Probable tRNA-dihydrouridine synthase OS=Rhi... 91 2e-017
sp|Q54CU9|DUS3L_DICDI tRNA-dihydrouridine synthase 3-like OS=Dic... 89 5e-017
>sp|Q8C2P3|DUS1L_MOUSE tRNA-dihydrouridine synthase 1-like OS=Mus musculus
GN=Dus1l PE=2 SV=1
Length = 475
Score = 278 bits (710), Expect = 8e-074
Identities = 131/254 (51%), Positives = 179/254 (70%), Gaps = 3/254 (1%)
Frame = -2
Query: 1213 KAWEHWKK-LGRPKYIVAPMVDNSELPFRLLCQKYGAQAAYTPMLHSRIFTETEKYRNQE 1037
+ +E W + LG +++VAPMVD SEL +RLL +++GAQ YTPMLH+++F YR +
Sbjct: 5 QGFEFWSRTLGGARHVVAPMVDQSELAWRLLSRRHGAQLCYTPMLHAQVFVRDANYRKEN 64
Query: 1036 F--TTCKEDRPLFVQFCANDPDTLLEAAKRVEPYCDYVDINLGCPQRIAKRGNYGAFLMD 863
C EDRPL VQFCANDP+ ++AA + YCD +D+NLGCPQ IAKRG+YGAFL +
Sbjct: 65 LYCDVCPEDRPLIVQFCANDPEVFVQAALLAQDYCDAIDLNLGCPQMIAKRGHYGAFLQE 124
Query: 862 NLPLVKSLVEKLAQNLIVPVSCKIRIFPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDG 683
L++ ++ + L VPV+CKIR+FP++ T+ YA+MLE+AGC LL VHGRT+++K
Sbjct: 125 EWDLLQRMILLAHERLSVPVTCKIRVFPEIDKTVRYAQMLEKAGCQLLTVHGRTKEQKGP 184
Query: 682 KKFRADWGAIKEVRKAMRIPVLANGNVRCVEDVDECIRETGVEGVLSAETLLENPAAFAG 503
A W IK VRKA+ IPV ANGN++C++DV+ CI++TGV+GV+SAE L NPA F G
Sbjct: 185 MAGTASWEHIKAVRKAVGIPVFANGNIQCLQDVERCIQDTGVQGVMSAEGNLHNPALFEG 244
Query: 502 FRTAEWAKEEGYVD 461
A W E Y+D
Sbjct: 245 RSPAVWELAEEYLD 258
>sp|Q8K582|DUS1L_RAT tRNA-dihydrouridine synthase 1-like OS=Rattus norvegicus
GN=Dus1l PE=2 SV=1
Length = 438
Score = 278 bits (710), Expect = 8e-074
Identities = 131/254 (51%), Positives = 178/254 (70%), Gaps = 3/254 (1%)
Frame = -2
Query: 1213 KAWEHWKK-LGRPKYIVAPMVDNSELPFRLLCQKYGAQAAYTPMLHSRIFTETEKYRNQE 1037
+ +E W + LG +++VAPMVD SEL +RLL +++GAQ YTPMLH+++F YR +
Sbjct: 5 QGFEFWSRALGGARHVVAPMVDQSELAWRLLSRRHGAQLCYTPMLHAQVFVRDANYRKEN 64
Query: 1036 F--TTCKEDRPLFVQFCANDPDTLLEAAKRVEPYCDYVDINLGCPQRIAKRGNYGAFLMD 863
C EDRPL VQFCANDP+ ++AA + YCD +D+NLGCPQ IAKRG YGAFL +
Sbjct: 65 LYCDVCPEDRPLIVQFCANDPEVFVQAALLAQDYCDAIDLNLGCPQMIAKRGRYGAFLQE 124
Query: 862 NLPLVKSLVEKLAQNLIVPVSCKIRIFPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDG 683
L++ ++ + L VPV+CKIR+FP++ T+ YA+MLE+AGC LL VHGRT+++K
Sbjct: 125 EWDLLQRMILLAHERLSVPVTCKIRVFPEIDKTVRYAQMLEKAGCQLLTVHGRTKEQKGP 184
Query: 682 KKFRADWGAIKEVRKAMRIPVLANGNVRCVEDVDECIRETGVEGVLSAETLLENPAAFAG 503
A W IK VRKA+ IPV ANGN+RC++DV+ CI++TGV+GV+SAE L NPA F G
Sbjct: 185 MAGTASWEHIKAVRKAVGIPVFANGNIRCLQDVERCIQDTGVQGVMSAEGNLHNPALFEG 244
Query: 502 FRTAEWAKEEGYVD 461
A W + Y+D
Sbjct: 245 RSPAVWELADEYLD 258
>sp|Q6P1R4|DUS1L_HUMAN tRNA-dihydrouridine synthase 1-like OS=Homo sapiens
GN=DUS1L PE=1 SV=1
Length = 473
Score = 278 bits (709), Expect = 1e-073
Identities = 131/254 (51%), Positives = 178/254 (70%), Gaps = 3/254 (1%)
Frame = -2
Query: 1213 KAWEHWKK-LGRPKYIVAPMVDNSELPFRLLCQKYGAQAAYTPMLHSRIFTETEKYRNQE 1037
+ +E W + L +++VAPMVD SEL +RLL +++GAQ YTPMLH+++F YR +
Sbjct: 5 QGFEFWSRTLRGARHVVAPMVDQSELAWRLLSRRHGAQLCYTPMLHAQVFVRDANYRKEN 64
Query: 1036 F--TTCKEDRPLFVQFCANDPDTLLEAAKRVEPYCDYVDINLGCPQRIAKRGNYGAFLMD 863
C EDRPL VQFCANDP+ ++AA + YCD +D+NLGCPQ IAKRG+YGAFL D
Sbjct: 65 LYCEVCPEDRPLIVQFCANDPEVFVQAALLAQDYCDAIDLNLGCPQMIAKRGHYGAFLQD 124
Query: 862 NLPLVKSLVEKLAQNLIVPVSCKIRIFPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDG 683
L++ ++ + L VPV+CKIR+FP++ T+ YA+MLE+AGC LL VHGRT+++K
Sbjct: 125 EWDLLQRMILLAHEKLSVPVTCKIRVFPEIDKTVRYAQMLEKAGCQLLTVHGRTKEQKGP 184
Query: 682 KKFRADWGAIKEVRKAMRIPVLANGNVRCVEDVDECIRETGVEGVLSAETLLENPAAFAG 503
A W IK VRKA+ IPV ANGN++C++DV+ C+R+TGV+GV+SAE L NPA F G
Sbjct: 185 LSGAASWEHIKAVRKAVAIPVFANGNIQCLQDVERCLRDTGVQGVMSAEGNLHNPALFEG 244
Query: 502 FRTAEWAKEEGYVD 461
A W E Y+D
Sbjct: 245 RSPAVWELAEEYLD 258
>sp|Q9HGN6|DUS1_SCHPO tRNA-dihydrouridine synthase 1 OS=Schizosaccharomyces
pombe GN=dus1 PE=2 SV=1
Length = 399
Score = 258 bits (658), Expect = 9e-068
Identities = 127/236 (53%), Positives = 170/236 (72%), Gaps = 4/236 (1%)
Frame = -2
Query: 1204 EHWKKLGRPKYIVAPMVDNSELPFRLLCQKYGAQAAYTPMLHSRIFTETEKYRNQEFT-- 1031
+ + K+GRPK I+APMVD SELP+R+L ++ GA Y+PM HSR+F E+E YRN+ F+
Sbjct: 10 DFYNKIGRPKRILAPMVDQSELPWRILARRSGADLCYSPMFHSRLFGESEDYRNKVFSTR 69
Query: 1030 TCKEDRPLFVQFCANDPDTLLEAAKRVEPYCDYVDINLGCPQRIAKRGNYGAFLMDNLPL 851
T E+RPL +QFC NDP+ +L+AAK PYCD VD+NLGCPQ IAK+G YG+FL +N L
Sbjct: 70 TIPEERPLIIQFCGNDPEIMLKAAKIAAPYCDAVDVNLGCPQGIAKKGKYGSFLQENWNL 129
Query: 850 VKSLVEKLAQNLIVPVSCKIRIFPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDGKKFR 671
++S++ KL L +PV+ KIRIFPD Q TL+YAKM+ +AG S+LAVHGR R++K
Sbjct: 130 IESIITKLHTELSIPVTAKIRIFPDPQKTLDYAKMILKAGASILAVHGRLREQKGHFTGI 189
Query: 670 ADWGAIKEVRKAM--RIPVLANGNVRCVEDVDECIRETGVEGVLSAETLLENPAAF 509
ADW I+ +RK + + ANGN+ +D+D CI+ TGV+GVLSAE L NP F
Sbjct: 190 ADWEQIQMLRKNLPSETVLFANGNILHAQDIDRCIKYTGVDGVLSAEGSLYNPRIF 245
>sp|P53759|DUS1_YEAST tRNA-dihydrouridine synthase 1 OS=Saccharomyces cerevisiae
GN=DUS1 PE=1 SV=1
Length = 423
Score = 242 bits (616), Expect = 6e-063
Identities = 134/304 (44%), Positives = 183/304 (60%), Gaps = 14/304 (4%)
Frame = -2
Query: 1192 KLGRPKYIVAPMVDNSELPFRLLCQKYGAQAAYTPMLHSRIFTETEKYRNQEFTT---CK 1022
K+GRP IVAPMVD SEL +R+L ++YGA AYTPMLH+++F ++KYR +++
Sbjct: 25 KIGRPTRIVAPMVDQSELAWRILSRRYGATLAYTPMLHAKLFATSKKYREDNWSSLDGSS 84
Query: 1021 EDRPLFVQFCANDPDTLLEAAKRVEPYCDYVDINLGCPQRIAKRGNYGAFLMDNLPLVKS 842
DRPL VQFCANDP+ LL AAK VE CD VD+NLGCPQ IAK+G+YG+FLM+ L+ +
Sbjct: 85 VDRPLVVQFCANDPEYLLAAAKLVEDKCDAVDLNLGCPQGIAKKGHYGSFLMEEWDLIHN 144
Query: 841 LVEKLAQNLIVPVSCKIRIFPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDGKKFRADW 662
L+ L +NL VPV+ KIRIF D + +LNYAKM+ +AG L VHGR R++K K A+W
Sbjct: 145 LINTLHKNLKVPVTAKIRIFDDCEKSLNYAKMVLDAGAQFLTVHGRVREQKGQKTGLANW 204
Query: 661 GAIKEVRKAM--RIPVLANGNVRCVEDVDECIRETGVEGVLSAETLLENPAAFAGFRTAE 488
IK +R + ANGN+ ED+ C+ G + V+SAE L NP F +T
Sbjct: 205 ETIKYLRDNLPKETVFFANGNILYPEDISRCMEHIGADAVMSAEGNLYNPGVFNVGQTKN 264
Query: 487 WAKEEGYVDGGLDQGDLVVEY---LKLCEKHPVPWRMIRSHVHKMLGDWFRVHPQVREEF 317
K VD ++ EY +K C++ ++SH K+L + H +R
Sbjct: 265 KEKIFPRVD------KIIREYFQIVKECQESKASKTAMKSHFFKILRPFLPHHTDIRSTL 318
Query: 316 NAQN 305
N
Sbjct: 319 ATMN 322
>sp|O95620|DUS4L_HUMAN tRNA-dihydrouridine synthase 4-like OS=Homo sapiens
GN=DUS4L PE=2 SV=2
Length = 317
Score = 173 bits (436), Expect = 5e-042
Identities = 100/246 (40%), Positives = 145/246 (58%), Gaps = 6/246 (2%)
Frame = -2
Query: 1171 IVAPMVDNSELPFRLLCQKYGAQAAYTPMLHSRIFTETEKYRNQEFTTCKEDRPLFVQFC 992
+ APMV S+L FR L +KY YTPM+ + F ++ K R+ EFTT + D PL VQF
Sbjct: 30 VCAPMVRYSKLAFRTLVRKYSCDLCYTPMIVAADFVKSIKARDSEFTTNQGDCPLIVQFA 89
Query: 991 ANDPDTLLEAAKRVEPYCDYVDINLGCPQRIAKRGNYGAFLMDNLPLVKSLVEKLAQNLI 812
AND L +AA+ V PY + +DIN GCPQR A YGA L++ LV+ +V+++ +
Sbjct: 90 ANDARLLSDAARIVCPYANGIDINCGCPQRWAMAEGYGACLINKPELVQDMVKQVRNQVE 149
Query: 811 VP---VSCKIRIFPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDGKKFRADWGAIKEVR 641
P VS KIRI DL+ T++ + E G S + VHGRT +E+ + +IK ++
Sbjct: 150 TPGFSVSIKIRIHDDLKRTVDLCQKAEATGVSWITVHGRTAEERHQP---VHYDSIKIIK 206
Query: 640 KAMRIPVLANGNVRCVEDVDECIRETGVEGVLSAETLLENPAAFAGFRTAEWAKEEGYVD 461
+ M IPV+ANG++R +++ + R TG +GV+ A LL NPA FAG+ +VD
Sbjct: 207 ENMSIPVIANGDIRSLKEAENVWRITGTDGVMVARGLLANPAMFAGYEETPLKCIWDWVD 266
Query: 460 GGLDQG 443
L+ G
Sbjct: 267 IALELG 272
>sp|Q32M08|DUS4L_MOUSE tRNA-dihydrouridine synthase 4-like OS=Mus musculus
GN=Dus4l PE=2 SV=1
Length = 324
Score = 167 bits (421), Expect = 3e-040
Identities = 98/246 (39%), Positives = 140/246 (56%), Gaps = 6/246 (2%)
Frame = -2
Query: 1171 IVAPMVDNSELPFRLLCQKYGAQAAYTPMLHSRIFTETEKYRNQEFTTCKEDRPLFVQFC 992
+ APMV S+L FR L +KY YTPM+ + F + K R+ EFTT + D PL VQF
Sbjct: 30 VCAPMVRYSKLAFRTLVRKYSCDLCYTPMIIAADFVRSIKARDSEFTTNQGDCPLIVQFA 89
Query: 991 ANDPDTLLEAAKRVEPYCDYVDINLGCPQRIAKRGNYGAFLMDNLPLVKSLVEKLAQNLI 812
AND L +AA V PY + +DIN GCPQR A YGA L++ LV +V ++ +
Sbjct: 90 ANDARLLSDAALLVCPYANGIDINCGCPQRWAMADGYGACLINKPELVHDMVRQVRNRVE 149
Query: 811 VP---VSCKIRIFPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDGKKFRADWGAIKEVR 641
P VS KIRI DL T++ + E G S + VHGRT +E+ + AIK ++
Sbjct: 150 SPRFSVSIKIRIHDDLARTIDLCRKAEATGVSWITVHGRTVEERHQP---VHYDAIKMIK 206
Query: 640 KAMRIPVLANGNVRCVEDVDECIRETGVEGVLSAETLLENPAAFAGFRTAEWAKEEGYVD 461
+ + IP++ANG++R +++ + + TG +GV+ A LL NPA FAG+ +VD
Sbjct: 207 ENVSIPIVANGDIRSLKEAENVWQMTGTDGVMVARGLLANPAMFAGYEETPLKCIWDWVD 266
Query: 460 GGLDQG 443
L+ G
Sbjct: 267 ISLELG 272
>sp|O74553|DUS4_SCHPO tRNA-dihydrouridine synthase 4 OS=Schizosaccharomyces
pombe GN=dus4 PE=2 SV=1
Length = 326
Score = 158 bits (398), Expect = 1e-037
Identities = 95/242 (39%), Positives = 136/242 (56%), Gaps = 5/242 (2%)
Frame = -2
Query: 1183 RPKYIVAPMVDNSELPFRLLCQKYGAQAAYTPMLHSRIFTETEKYRNQEFTTCKEDRPLF 1004
RP +I APMV S+LPFR L + Y YTPM+ ++ F K R +F+T D L
Sbjct: 19 RPVHIAAPMVRYSKLPFRQLVRDYNTDIVYTPMILAKEFLH-PKGRYFDFSTNDADASLI 77
Query: 1003 VQFCANDPDTLLEAAKRVEPYCDYVDINLGCPQRIAKRGNYGAFLMDNLPLVKSLVEKLA 824
+QF +DP L +AA+ V PY D + IN GCPQ A + G+ L+D V LV +
Sbjct: 78 LQFGVDDPVILEKAAQLVGPYVDGIGINCGCPQTWAIQEGIGSALLDEPEKVHKLVRAVK 137
Query: 823 QNL--IVPVSCKIRIFPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDGKKFRADWGAIK 650
L KIRI DL T + +++E++G ++ VHGRTR +D F + AI+
Sbjct: 138 STLGESFCTEVKIRIAKDLNKTRHLMQVIEKSGADIITVHGRTR--QDRSSFPVNLDAIR 195
Query: 649 EVRKAMRIPVLANGNVRCVEDVDECIRETGVEGVLSAETLLENPAAFAGFRTAEWAKEEG 470
EVR ++IPV+ANG+V+ + E + T +G++SA LLENPA FAG+ W E
Sbjct: 196 EVRPCVQIPVVANGDVKSLRKGLEIAKYTETQGIMSARGLLENPALFAGYEETPWGCVER 255
Query: 469 YV 464
++
Sbjct: 256 FL 257
>sp|Q06063|DUS4_YEAST tRNA-dihydrouridine synthase 4 OS=Saccharomyces cerevisiae
GN=DUS4 PE=1 SV=1
Length = 367
Score = 151 bits (380), Expect = 1e-035
Identities = 91/258 (35%), Positives = 134/258 (51%), Gaps = 7/258 (2%)
Frame = -2
Query: 1195 KKLGRPKYIVAPMVDNSELPFRLLCQKYGAQAAYTPMLHSRIFTETEKYRNQEFTTCKED 1016
K GRP I PMV S+LPFR LC++Y Y+PM+ +R + E R + +T ED
Sbjct: 34 KTHGRPVTIAGPMVRYSKLPFRQLCREYNVDIVYSPMILAREYVRNEHARISDLSTNNED 93
Query: 1015 RPLFVQFCANDPDTLLEAAKRVEPYCDYVDINLGCPQRIAKRGNYGAFLMDNLPLVKSLV 836
PL VQ N+ LL+ + V PYCD + IN GCP + R G L+ N L+ S+V
Sbjct: 94 TPLIVQVGVNNVADLLKFVEMVAPYCDGIGINCGCPIKEQIREGIGCALIYNSDLLCSMV 153
Query: 835 EKLAQNL--IVPVSCKIRIFPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDGKKFRADW 662
+ + + KIRI L +T+ + L +AG + +HGRTR + + D
Sbjct: 154 HAVKDKYGDKLRIETKIRIHEALDETVELCRKLCDAGVDWITIHGRTRRTRSSQPANLD- 212
Query: 661 GAIKEVRKAM---RIPVLANGNVRCVEDVDECIRETGVEGVLSAETLLENPAAFAGFRTA 491
AIK + + + +PV+ANG+ + D++ + TG GV++ LL NPA FAG+ T
Sbjct: 213 -AIKYIIENISDKNVPVIANGDCFKLSDLERITKYTGAHGVMAVRGLLSNPALFAGYTTC 271
Query: 490 EWAKEEGYVDGGLDQGDL 437
W E + L+ G L
Sbjct: 272 PWGCIEKFCYWALEFGGL 289
>sp|Q8EJR8|DUSB_SHEON tRNA-dihydrouridine synthase B OS=Shewanella oneidensis
GN=dusB PE=3 SV=1
Length = 322
Score = 113 bits (281), Expect = 5e-024
Identities = 76/213 (35%), Positives = 120/213 (56%), Gaps = 7/213 (3%)
Frame = -2
Query: 1171 IVAPMVDNSELPFRLLCQKYGAQAAYTPMLHSR-IFTETEKYRNQEFTTCKEDRPLFVQF 995
IVAPM ++ FR LC +YGA A + ML S +T+K R Q T E+ VQ
Sbjct: 13 IVAPMAGVTDQAFRNLCLRYGAALAVSEMLSSNPEVWDTDKSR-QRMTHSGEEGIRSVQI 71
Query: 994 CANDPDTLLEAAK-RVEPYCDYVDINLGCPQRIAKRGNYGAFLMDNLPLVKSLVEKLAQN 818
DP+ + +AA+ VE +DIN+GCP + + G+ LM N PLVK +++ +
Sbjct: 72 AGADPELMAQAAQFNVEQGAHIIDINMGCPAKKVNKKLAGSALMQNPPLVKDILQAVVAA 131
Query: 817 LIVPVSCKIRI--FPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDGKKFRADWGAIKEV 644
+ VPV+ KIR P+ ++ + A++ E+ G + LAVHGRTR + K A++ IK +
Sbjct: 132 VDVPVTLKIRTGWEPEHRNGVQIAQIAEDCGIASLAVHGRTR--QCMYKGNAEYDTIKAI 189
Query: 643 RKAMRIPVLANGNVRCVEDVDECIRETGVEGVL 545
++ + IPV+ANG++ E + TGV+ ++
Sbjct: 190 KQNVSIPVVANGDIDSPEKARFVLDYTGVDALM 222
>sp|Q8PP72|DUSB_XANAC tRNA-dihydrouridine synthase B OS=Xanthomonas axonopodis
pv. citri GN=dusB PE=3 SV=1
Length = 332
Score = 112 bits (280), Expect = 6e-024
Identities = 75/228 (32%), Positives = 121/228 (53%), Gaps = 7/228 (3%)
Frame = -2
Query: 1180 PKYIVAPMVDNSELPFRLLCQKYGAQAAYTPM-LHSRIFTETEKYRNQEFTTCKEDRPLF 1004
PK I+APM ++ PFRLLC++ GA A + M + F T K ++ E P+
Sbjct: 10 PKVILAPMAGVTDKPFRLLCKRLGAGLAVSEMTISDPRFWGTRKSLHR-MDHAGEPDPIS 68
Query: 1003 VQFCANDPDTLLEAAK-RVEPYCDYVDINLGCPQRIAKRGNYGAFLMDNLPLVKSLVEKL 827
VQ +P L EAA+ V+ +DIN+GCP + G+ LM + LV ++ +
Sbjct: 69 VQIAGTEPQQLAEAARYNVDHGAQLIDINMGCPAKKVCNAWAGSALMRDEELVARILTAV 128
Query: 826 AQNLIVPVSCKIRIFPDL--QDTLNYAKMLEEAGCSLLAVHGRTRDEKDGKKFRADWGAI 653
Q + VPV+ KIR D ++ A++ ++ G + LAVHGRTRD+ A++ I
Sbjct: 129 VQAVNVPVTLKIRTGWDCDHRNGPTIARIAQDCGIAALAVHGRTRDQH--YTGSAEYATI 186
Query: 652 KEVRKAMRIPVLANGNVRCVEDVDECIRETGVEGVLSAETLLENPAAF 509
+++ A++IPV+ANG++ + + +RETG + V+ P F
Sbjct: 187 AQIKAALQIPVVANGDIDSPQKAAQVLRETGADAVMIGRAAQGRPWIF 234
>sp|Q9D7B1|DUS2L_MOUSE tRNA-dihydrouridine synthase 2-like OS=Mus musculus
GN=Dus2l PE=1 SV=1
Length = 493
Score = 108 bits (268), Expect = 1e-022
Identities = 59/181 (32%), Positives = 99/181 (54%), Gaps = 7/181 (3%)
Frame = -2
Query: 1036 FTTCKEDRPLFV-QFCANDPDTLLEAAKRVEPYCDYVDINLGCPQRIAKRGNYGAFLMDN 860
F TC+ ++ V Q +D + L A+ VE +D+N+GCP+ + +G GA L+ +
Sbjct: 74 FRTCEREQSRVVFQMGTSDAERALAVARLVENDVAGIDVNMGCPKEYSTKGGMGAALLSD 133
Query: 859 LPLVKSLVEKLAQNLIVPVSCKIRIFPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDGK 680
++ ++ L + PV+CKIRI P L+DTLN K +E G S +AVHGR RDE+
Sbjct: 134 PDKIEKILSTLVKGTHRPVTCKIRILPSLEDTLNLVKRIERTGISAIAVHGRNRDERPQH 193
Query: 679 KFRADWGAIKEVRKAMRIPVLANG----NVRCVEDVDECIRETGVEGVLSAETLLENPAA 512
+ I+ + + + IPV+ANG +++ D+++ + T V+ A + NP+
Sbjct: 194 PVSCE--VIRAIAETLSIPVIANGGSHDHIQQHVDIEDFRQATAASSVMVARAAMWNPSI 251
Query: 511 F 509
F
Sbjct: 252 F 252
>sp|Q9NX74|DUS2L_HUMAN tRNA-dihydrouridine synthase 2-like OS=Homo sapiens
GN=DUS2L PE=1 SV=1
Length = 493
Score = 105 bits (261), Expect = 9e-022
Identities = 57/181 (31%), Positives = 98/181 (54%), Gaps = 7/181 (3%)
Frame = -2
Query: 1036 FTTC-KEDRPLFVQFCANDPDTLLEAAKRVEPYCDYVDINLGCPQRIAKRGNYGAFLMDN 860
F TC +E + Q +D + L A+ VE +D+N+GCP++ + +G GA L+ +
Sbjct: 74 FRTCEREQNRVVFQMGTSDAERALAVARLVENDVAGIDVNMGCPKQYSTKGGMGAALLSD 133
Query: 859 LPLVKSLVEKLAQNLIVPVSCKIRIFPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDGK 680
++ ++ L + PV+CKIRI P L+DTL+ K +E G + +AVHGR R+E+
Sbjct: 134 PDKIEKILSTLVKGTRRPVTCKIRILPSLEDTLSLVKRIERTGIAAIAVHGRKREERPQH 193
Query: 679 KFRADWGAIKEVRKAMRIPVLANG----NVRCVEDVDECIRETGVEGVLSAETLLENPAA 512
+ IK + + IPV+ANG +++ D+++ + T V+ A + NP+
Sbjct: 194 PVSCE--VIKAIADTLSIPVIANGGSHDHIQQYSDIEDFRQATAASSVMVARAAMWNPSI 251
Query: 511 F 509
F
Sbjct: 252 F 252
>sp|P37567|DUS1_BACSU Probable tRNA-dihydrouridine synthase 1 OS=Bacillus
subtilis GN=dus1 PE=3 SV=1
Length = 333
Score = 103 bits (256), Expect = 4e-021
Identities = 74/262 (28%), Positives = 130/262 (49%), Gaps = 13/262 (4%)
Frame = -2
Query: 1177 KYIVAPMVDNSELPFRLLCQKYGAQAAYTPMLHSRIFTETEKYRNQEFTTCKEDRPLFVQ 998
+ ++APM FRL +++GA M+ + + ++PL +Q
Sbjct: 12 RVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVSDKAILYNNARTMGMLYIDEREKPLSLQ 71
Query: 997 FCANDPDTLLEAAKRVE--PYCDYVDINLGCPQRIAKRGNYGAFLMDNLPLVKSLVEKLA 824
+TL+EAAK V+ D +DIN+GCP + + GA + + + +V +
Sbjct: 72 IFGGKKETLVEAAKFVDQNTTADIIDINMGCPVPKITKCDAGAKWLLDPDKIYEMVSAVV 131
Query: 823 QNLIVPVSCKIRIFPDLQD--TLNYAKMLEEAGCSLLAVHGRTRDEKDGKKFRADWGAIK 650
+ PV+ K+R+ D + A+ +E AG +A+HGRTR + + A+W IK
Sbjct: 132 DAVNKPVTVKMRMGWDEDHIFAVKNAQAVERAGGKAVALHGRTRVQM--YEGTANWDIIK 189
Query: 649 EVRKAMRIPVLANGNVRCVEDVDECIRETGVEGVLSAETLLENPAAFAGFRTAEWAKEEG 470
EV++++ IPV+ NG+V+ +D + ETGV+GV+ L NP + +RT ++ +
Sbjct: 190 EVKQSVSIPVIGNGDVKTPQDAKRMLDETGVDGVMIGRAALGNP--WMIYRTVQYLE--- 244
Query: 469 YVDGGLDQGDLVVEYLKLCEKH 404
G L + V E + +C+ H
Sbjct: 245 --TGKLKEEPQVREKMAVCKLH 264
>sp|P0A2R7|DUSB_SALTI tRNA-dihydrouridine synthase B OS=Salmonella typhi GN=dusB
PE=3 SV=1
Length = 321
Score = 93 bits (229), Expect = 5e-018
Identities = 64/228 (28%), Positives = 108/228 (47%), Gaps = 5/228 (2%)
Frame = -2
Query: 1183 RPKYIVAPMVDNSELPFRLLCQKYGAQAAYTPMLHSRIFTETEKYRNQEFTTCKEDRPLF 1004
R + I APM ++ PFR LC + GA + M+ S E
Sbjct: 9 RNRLIAAPMAGITDRPFRTLCYEMGAGLTVSEMMSSNPQVWESDKSRLRMVHVDEPGIRT 68
Query: 1003 VQFCANDPDTLLEAAK-RVEPYCDYVDINLGCPQRIAKRGNYGAFLMDNLPLVKSLVEKL 827
VQ +DP + +AA+ VE +DIN+GCP + R G+ L+ LVKS++ +
Sbjct: 69 VQIAGSDPVEMADAARINVESGAQIIDINMGCPAKKVNRKLAGSALLQYPDLVKSILIGV 128
Query: 826 AQNLIVPVSCKIRI--FPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDGKKFRADWGAI 653
+ VPV+ KIR P+ ++ + A++ E+ G L +HGRTR + A++ +I
Sbjct: 129 VNAVDVPVTLKIRTGWAPEHRNCVEIAQLAEDCGIQALTIHGRTRACLFNGE--AEYDSI 186
Query: 652 KEVRKAMRIPVLANGNVRCVEDVDECIRETGVEGVLSAETLLENPAAF 509
+ V++ + IP++ANG++ + TG + ++ P F
Sbjct: 187 RAVKQKVSIPIIANGDITNPHKARAVLDYTGADALMIGRAAQGRPWIF 234
>sp|P0A2R6|DUSB_SALTY tRNA-dihydrouridine synthase B OS=Salmonella typhimurium
GN=dusB PE=3 SV=1
Length = 321
Score = 93 bits (229), Expect = 5e-018
Identities = 64/228 (28%), Positives = 108/228 (47%), Gaps = 5/228 (2%)
Frame = -2
Query: 1183 RPKYIVAPMVDNSELPFRLLCQKYGAQAAYTPMLHSRIFTETEKYRNQEFTTCKEDRPLF 1004
R + I APM ++ PFR LC + GA + M+ S E
Sbjct: 9 RNRLIAAPMAGITDRPFRTLCYEMGAGLTVSEMMSSNPQVWESDKSRLRMVHVDEPGIRT 68
Query: 1003 VQFCANDPDTLLEAAK-RVEPYCDYVDINLGCPQRIAKRGNYGAFLMDNLPLVKSLVEKL 827
VQ +DP + +AA+ VE +DIN+GCP + R G+ L+ LVKS++ +
Sbjct: 69 VQIAGSDPVEMADAARINVESGAQIIDINMGCPAKKVNRKLAGSALLQYPDLVKSILIGV 128
Query: 826 AQNLIVPVSCKIRI--FPDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDGKKFRADWGAI 653
+ VPV+ KIR P+ ++ + A++ E+ G L +HGRTR + A++ +I
Sbjct: 129 VNAVDVPVTLKIRTGWAPEHRNCVEIAQLAEDCGIQALTIHGRTRACLFNGE--AEYDSI 186
Query: 652 KEVRKAMRIPVLANGNVRCVEDVDECIRETGVEGVLSAETLLENPAAF 509
+ V++ + IP++ANG++ + TG + ++ P F
Sbjct: 187 RAVKQKVSIPIIANGDITNPHKARAVLDYTGADALMIGRAAQGRPWIF 234
>sp|P41504|DUS_RHILP Probable tRNA-dihydrouridine synthase OS=Rhizobium
leguminosarum bv. phaseoli GN=dus PE=3 SV=1
Length = 317
Score = 91 bits (224), Expect = 2e-017
Identities = 54/161 (33%), Positives = 89/161 (55%), Gaps = 7/161 (4%)
Frame = -2
Query: 1015 RPLFVQFCANDPDTLLEAAKRVEPY-CDYVDINLGCPQRIAKRGNYGAFLMDNLPLVKSL 839
RP VQ + + EAAK + D +DIN+GCP + G G+ LM + L
Sbjct: 59 RPHMVQLAGREAHWMAEAAKIAADHGADIIDINMGCPAKKVIGGYSGSALMRDPDHALGL 118
Query: 838 VEKLAQNLIVPVSCKIRIFPDLQDTLN---YAKMLEEAGCSLLAVHGRTRDEKDGKKFRA 668
+E + + +PV+ K+R+ D ++++N A+ E +G L+ +HGRTR + RA
Sbjct: 119 IEATVKAVDIPVTLKMRLGWD-ENSINAPDIARRAEASGIQLVTIHGRTR--MQFYEGRA 175
Query: 667 DWGAIKEVRKAMRIPVLANGNVRCVEDVDECIRETGVEGVL 545
DW AI+ VR+ + +P++ANG+V D E +R +G + V+
Sbjct: 176 DWDAIRAVREVISVPLIANGDVETAHDAQEILRRSGADAVM 216
>sp|Q54CU9|DUS3L_DICDI tRNA-dihydrouridine synthase 3-like OS=Dictyostelium
discoideum GN=dus3l PE=3 SV=1
Length = 671
Score = 89 bits (220), Expect = 5e-017
Identities = 71/280 (25%), Positives = 123/280 (43%), Gaps = 7/280 (2%)
Frame = -2
Query: 1309 TQNTDPTNPDPSQQQQQQQPESLSIVDDRRVEKAWEHWKKLGRPKYIVAPMVDNSELPFR 1130
T+ T+ T +++++ +Q + +D KA E + + I+AP+ LPFR
Sbjct: 281 TEKTEKTETTETKKEEFKQSNENTEIDIMTPLKANEKKRINFENQLILAPLTTVGNLPFR 340
Query: 1129 LLCQKYGAQAAYTPMLHSRIFTETEKYRNQEFTTCKEDRPLFVQFCANDPDTLLEAAKRV 950
+C++ GA M + E K + VQ C + D ++ A+ +
Sbjct: 341 RICKRLGADITIGEMALTTKLLEGTKSELALLKRHPCEDKFGVQICGSYVDAAVKCAEFI 400
Query: 949 EPY--CDYVDINLGCPQRIAKRGNYGAFLMDNLPLVKSLVEKLAQNLIVPVSCKIRI--F 782
E D+VDIN GCP + GA LM+ V+ L+ ++ +L P + KIRI
Sbjct: 401 ENEIDADFVDINSGCPIDLVCNMGAGAALMERPKKVEQLLRGISSSLSCPTTIKIRIGKS 460
Query: 781 PDLQDTLNYAKMLEEAGCSLLAVHGRTRDEKDGKKFRADWGAIKEVRKAMRIPVLANGNV 602
D L E G + +HGR+R ++ + A+W +K+ + IP++ NG++
Sbjct: 461 EDAPTAHKLIPSLGEWGACAVTLHGRSRAQRYSR--LANWDYVKQCSEVSSIPLIGNGDI 518
Query: 601 RCVEDVDECIRETGVEGVLSAETLLENPAAFAGFR-TAEW 485
+DV + V ++ A L P F + EW
Sbjct: 519 YNYQDVVNIYDSSKVSSIMIARGALIKPWIFTEIKEKREW 558
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,733,448,049
Number of Sequences: 518415
Number of Extensions: 32733448049
Number of Successful Extensions: 231167770
Number of sequences better than 0.0: 0
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