BLASTX 7.6.2
Query= UN08215 /QuerySize=1495
(1494 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q96CN4|EVI5L_HUMAN EVI5-like protein OS=Homo sapiens GN=EVI5L... 194 2e-048
sp|O60447|EVI5_HUMAN Ecotropic viral integration site 5 protein ... 192 8e-048
sp|Q9VYY9|Y1727_DROME TBC1 domain family member CG11727 OS=Droso... 189 7e-047
sp|Q9Y3P9|RBGP1_HUMAN Rab GTPase-activating protein 1 OS=Homo sa... 178 9e-044
sp|Q5RAN1|RBGP1_PONAB Rab GTPase-activating protein 1 OS=Pongo a... 178 9e-044
sp|A2AWA9|RBGP1_MOUSE Rab GTPase-activating protein 1 OS=Mus mus... 178 2e-043
sp|Q5R372|RBG1L_HUMAN Rab GTPase-activating protein 1-like OS=Ho... 177 3e-043
sp|Q5RCW6|RBG1L_PONAB Rab GTPase-activating protein 1-like OS=Po... 177 3e-043
sp|A6H6A9|RBG1L_MOUSE Rab GTPase-activating protein 1-like OS=Mu... 176 6e-043
sp|Q5ZJ17|RBG1L_CHICK Rab GTPase-activating protein 1-like OS=Ga... 175 8e-043
sp|P97366|EVI5_MOUSE Ecotropic viral integration site 5 protein ... 169 7e-041
sp|Q80XC3|US6NL_MOUSE USP6 N-terminal-like protein OS=Mus muscul... 161 1e-038
sp|Q92738|US6NL_HUMAN USP6 N-terminal-like protein OS=Homo sapie... 161 2e-038
sp|Q86TI0|TBCD1_HUMAN TBC1 domain family member 1 OS=Homo sapien... 149 6e-035
sp|Q60949|TBCD1_MOUSE TBC1 domain family member 1 OS=Mus musculu... 149 8e-035
sp|O97790|TBCD1_BOVIN TBC1 domain family member 1 (Fragment) OS=... 144 2e-033
sp|O60343|TBCD4_HUMAN TBC1 domain family member 4 OS=Homo sapien... 144 3e-033
sp|Q8BYJ6|TBCD4_MOUSE TBC1 domain family member 4 OS=Mus musculu... 143 6e-033
sp|Q12344|GYP5_YEAST GTPase-activating protein GYP5 OS=Saccharom... 130 4e-029
sp|Q8IZP1|TBC3A_HUMAN TBC1 domain family member 3 OS=Homo sapien... 117 3e-025
>sp|Q96CN4|EVI5L_HUMAN EVI5-like protein OS=Homo sapiens GN=EVI5L PE=1 SV=1
Length = 794
Score = 194 bits (491), Expect = 2e-048
Identities = 118/332 (35%), Positives = 186/332 (56%), Gaps = 17/332 (5%)
Frame = +1
Query: 223 HRLIDLGFSSSRNTATILLNVSSRLIDHLPTMKSICLNWEERRVTKWRKMIGAGGSDWKH 402
+RL++ S R+ N S L+ ++ + EE W G ++W+
Sbjct: 45 NRLLEADSKSMRSMNGSRRNSGSSLVSSSSASSNLS-HLEEDTWILW----GRIANEWEE 99
Query: 403 YVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNPGVYEQLVVYETSASELDIIR 582
+ RRK ++K IRKGIP R +VWQL+ + D+ + N Y +L+ + +L I R
Sbjct: 100 WRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ--YSELLKMSSPCEKL-IRR 156
Query: 583 DISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVGYVQGMGFVAGLLLLYMSEEDAF 762
DI+RT+P H FF+ + GQ L+NV+KAYS+ DR+VGY QG F+ GLLL+ M EE+AF
Sbjct: 157 DIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAF 216
Query: 763 WLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVRELMPKLGEHFTQEMINPSMYAS 942
+ V L++ + L++ + + + QF+ +++E +P L HF + + SMYAS
Sbjct: 217 CVFVRLMQ---EYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYAS 273
Query: 943 QWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLALLKHCHDDLVKLPFEELMHALRN 1122
WF+T+F +FP A R++D+F+ EG+ IVF+VGLALL+ +L++L E + +
Sbjct: 274 SWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQR 333
Query: 1123 FPEDAMD--PDTLLPLAYSIKV----AKRLEE 1200
D PD L+ AY +K KRLE+
Sbjct: 334 VIPHQFDSCPDKLVLKAYQVKYNPKKMKRLEK 365
>sp|O60447|EVI5_HUMAN Ecotropic viral integration site 5 protein homolog OS=Homo
sapiens GN=EVI5 PE=1 SV=2
Length = 810
Score = 192 bits (486), Expect = 8e-048
Identities = 112/333 (33%), Positives = 194/333 (58%), Gaps = 14/333 (4%)
Frame = +1
Query: 223 HRLIDLGFSSSRNTATILLNVSSRLIDHLPTMKSICLNWEERRVTKWRKMIGAGGSDWKH 402
+RL++ S R+ N S L+ ++ + EE W +++ ++W+
Sbjct: 93 NRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLS-HLEEDSWILWGRIV----NEWED 147
Query: 403 YVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNPGVYEQLVVYETSASELDIIR 582
++K VK + KGIP R +VWQL+ ++ + + + Y +L+ TS E I R
Sbjct: 148 VRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ--YSELLKM-TSPCEKLIRR 204
Query: 583 DISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVGYVQGMGFVAGLLLLYMSEEDAF 762
DI+RT+P H FF+++ GQ L+NV+KAYS+ DR+VGY QG F+ GLLL+ M EE+AF
Sbjct: 205 DIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAF 264
Query: 763 WLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVRELMPKLGEHFTQEMINPSMYAS 942
+ V L++ + L++ + + + QF+ +++E +P+L HF + + SMYAS
Sbjct: 265 CVFVKLMQ---DYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYAS 321
Query: 943 QWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLALLKHCHDDLVKLPFEELMHALRN 1122
WF+T+F +FP A RI+D+F++EG+ IVF+VGLALL+ +L++L E ++ +
Sbjct: 322 SWFLTIFLTTFPLPVATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQK 381
Query: 1123 FPEDAMD--PDTLLPLAYSIKV-AKRLEEMKQD 1212
D PD L+ AY +K +K++++++++
Sbjct: 382 VIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKE 414
>sp|Q9VYY9|Y1727_DROME TBC1 domain family member CG11727 OS=Drosophila
melanogaster GN=CG11727 PE=1 SV=3
Length = 807
Score = 189 bits (478), Expect = 7e-047
Identities = 108/280 (38%), Positives = 171/280 (61%), Gaps = 14/280 (5%)
Frame = +1
Query: 388 SDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNPGVYEQLVVY--ETSA 561
+DW+ ++RK V +R+GIP R +VWQ +SG+ D G +Q Y TSA
Sbjct: 96 NDWEGALKRKNPCVSELVRRGIPHHFRAIVWQQLSGASD------GDKKQYAEYIKATSA 149
Query: 562 SELDIIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVGYVQGMGFVAGLLLLY 741
E I RDI+RT+P FF+++ GPGQ +L+NV+KAYS++DR+VGY QG GF+ GLLL+
Sbjct: 150 CEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQ 209
Query: 742 MSEEDAFWLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVRELMPKLGEHFTQEMI 921
M EE+AF +LV +++ M +++ + + + Q + LV+E +P + HF Q+
Sbjct: 210 MPEEEAFAVLVQIMQ---QHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGF 266
Query: 922 NPSMYASQWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLALLKHCHDDLVKLPFEE 1101
+MYAS WF+T+++ + + + RI DVFL+EG+ +FKV LALL D L+ L E
Sbjct: 267 QTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCLDMEA 326
Query: 1102 LMHALRNFPEDAMDPDT--LLPLAYSIKV-AKRLEEMKQD 1212
++ + ++ D LAYSIK+ KR+++M+++
Sbjct: 327 MLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKE 366
>sp|Q9Y3P9|RBGP1_HUMAN Rab GTPase-activating protein 1 OS=Homo sapiens
GN=RABGAP1 PE=1 SV=3
Length = 1069
Score = 178 bits (451), Expect = 9e-044
Identities = 106/314 (33%), Positives = 174/314 (55%), Gaps = 18/314 (5%)
Frame = +1
Query: 343 ERRVTKWRKMIGAGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNP 522
E+ + W +++ S W + +P + +R G+P+ LRG VWQL++G + N
Sbjct: 535 EKILETWGELL----SKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHN----ND 586
Query: 523 GVYEQLVVYETSASELD--IIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVG 696
+ E+ + T S D I RDI+RTFP+H +F+ G GQ SLY + KAYSVYD ++G
Sbjct: 587 HLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIG 646
Query: 697 YVQGMGFVAGLLLLYMSEEDAFWLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVR 876
Y QG F+A +LLL+M EE AF +LV ++ + L++ + Q ++L++
Sbjct: 647 YCQGQSFLAAVLLLHMPEEQAFSVLVKIM---FDYGLRELFKQNFEDLHCKFYQLERLMQ 703
Query: 877 ELMPKLGEHFTQEMINPSMYASQWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLAL 1056
E +P L HF + MYASQWF+T+F+ FP + I D+ L EGI ++F V L L
Sbjct: 704 EYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGL 763
Query: 1057 LKHCHDDLVKLPFEELMHALR-NFPEDAMDPDT---LLPLAYSIKVA-KRLEEMKQDGEK 1221
LK DDL+ FE + R P+ + L+ LA ++K++ K+L++ +++
Sbjct: 764 LKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHT 823
Query: 1222 TVAKPAKTTNPVQQ 1263
+ A+ +P+++
Sbjct: 824 MREQQAQQEDPIER 837
>sp|Q5RAN1|RBGP1_PONAB Rab GTPase-activating protein 1 OS=Pongo abelii
GN=RABGAP1 PE=2 SV=1
Length = 1069
Score = 178 bits (451), Expect = 9e-044
Identities = 106/314 (33%), Positives = 174/314 (55%), Gaps = 18/314 (5%)
Frame = +1
Query: 343 ERRVTKWRKMIGAGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNP 522
E+ + W +++ S W + +P + +R G+P+ LRG VWQL++G + N
Sbjct: 535 EKILETWGELL----SKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHN----ND 586
Query: 523 GVYEQLVVYETSASELD--IIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVG 696
+ E+ + T S D I RDI+RTFP+H +F+ G GQ SLY + KAYSVYD ++G
Sbjct: 587 HLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIG 646
Query: 697 YVQGMGFVAGLLLLYMSEEDAFWLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVR 876
Y QG F+A +LLL+M EE AF +LV ++ + L++ + Q ++L++
Sbjct: 647 YCQGQSFLAAVLLLHMPEEQAFSVLVKIM---FDYGLRELFKQNFEDLHCKFYQLERLMQ 703
Query: 877 ELMPKLGEHFTQEMINPSMYASQWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLAL 1056
E +P L HF + MYASQWF+T+F+ FP + I D+ L EGI ++F V L L
Sbjct: 704 EYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGL 763
Query: 1057 LKHCHDDLVKLPFEELMHALR-NFPEDAMDPDT---LLPLAYSIKVA-KRLEEMKQDGEK 1221
LK DDL+ FE + R P+ + L+ LA ++K++ K+L++ +++
Sbjct: 764 LKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHT 823
Query: 1222 TVAKPAKTTNPVQQ 1263
+ A+ +P+++
Sbjct: 824 MREQQAQQEDPIER 837
>sp|A2AWA9|RBGP1_MOUSE Rab GTPase-activating protein 1 OS=Mus musculus
GN=Rabgap1 PE=2 SV=1
Length = 1064
Score = 178 bits (449), Expect = 2e-043
Identities = 106/314 (33%), Positives = 173/314 (55%), Gaps = 18/314 (5%)
Frame = +1
Query: 343 ERRVTKWRKMIGAGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNP 522
E+ + W +++ S W + +P + +R G+P+ LRG VWQL++G + N
Sbjct: 530 EKILETWGELL----SKWHLNLSVRPKQLSSLVRSGVPEALRGEVWQLLAGCHN----ND 581
Query: 523 GVYEQLVVYETSASELD--IIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVG 696
+ E+ + T S D I RDI+RTFP+H +F+ G GQ SLY + KAYSVYD ++G
Sbjct: 582 HLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIG 641
Query: 697 YVQGMGFVAGLLLLYMSEEDAFWLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVR 876
Y QG F+A +LLL+M EE AF +LV ++ + L++ + Q ++L++
Sbjct: 642 YCQGQSFLAAVLLLHMPEEQAFSVLVKIM---FDYGLRELFKQNFEDLHCKFYQLERLMQ 698
Query: 877 ELMPKLGEHFTQEMINPSMYASQWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLAL 1056
E +P L HF + MYASQWF+T+F+ FP + I D+ L EGI ++F V L L
Sbjct: 699 EYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGL 758
Query: 1057 LKHCHDDLVKLPFEELMHALR-NFPEDAMDPDT---LLPLAYSIKVA-KRLEEMKQDGEK 1221
LK DDL+ FE + R P+ + L+ LA + K++ K+L++ +++
Sbjct: 759 LKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKRLMELACNTKISQKKLKKFEKEYHT 818
Query: 1222 TVAKPAKTTNPVQQ 1263
+ A+ +P+++
Sbjct: 819 MREQQAQQEDPIER 832
>sp|Q5R372|RBG1L_HUMAN Rab GTPase-activating protein 1-like OS=Homo sapiens
GN=RABGAP1L PE=1 SV=1
Length = 815
Score = 177 bits (447), Expect = 3e-043
Identities = 97/259 (37%), Positives = 147/259 (56%), Gaps = 9/259 (3%)
Frame = +1
Query: 343 ERRVTKWRKMIGAGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNP 522
E+ + W +++G W + +P + ++ G+P+ LR VWQL++G D M
Sbjct: 507 EKILYSWGELLG----KWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLD 562
Query: 523 GVYEQLVVYETSASELDIIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVGYV 702
++++ + SA E I RDI RTFP+H +F+ G GQ SLY + KAYSVYD D+GY
Sbjct: 563 RY--RILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYC 620
Query: 703 QGMGFVAGLLLLYMSEEDAFWLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVREL 882
QG F+A +LLL+M EE AF +LV ++ + LY+ + Q ++L++E
Sbjct: 621 QGQSFLAAVLLLHMPEEQAFCVLVKIM---YDYGLRDLYRNNFEDLHCKFYQLERLMQEQ 677
Query: 883 MPKLGEHFTQEMINPSMYASQWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLALLK 1062
+P L HF+ + MYASQWF+T+F+ FP I D+ L EG+ I+F V LALLK
Sbjct: 678 LPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLK 737
Query: 1063 HCHDDLVKLPFEELMHALR 1119
+DL++ FE + R
Sbjct: 738 TSKEDLLQADFEGALKFFR 756
>sp|Q5RCW6|RBG1L_PONAB Rab GTPase-activating protein 1-like OS=Pongo abelii
GN=RABGAP1L PE=2 SV=1
Length = 815
Score = 177 bits (447), Expect = 3e-043
Identities = 97/259 (37%), Positives = 147/259 (56%), Gaps = 9/259 (3%)
Frame = +1
Query: 343 ERRVTKWRKMIGAGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNP 522
E+ + W +++G W + +P + ++ G+P+ LR VWQL++G D M
Sbjct: 507 EKILYSWGELLG----KWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLD 562
Query: 523 GVYEQLVVYETSASELDIIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVGYV 702
++++ + SA E I RDI RTFP+H +F+ G GQ SLY + KAYSVYD D+GY
Sbjct: 563 RY--RILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYC 620
Query: 703 QGMGFVAGLLLLYMSEEDAFWLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVREL 882
QG F+A +LLL+M EE AF +LV ++ + LY+ + Q ++L++E
Sbjct: 621 QGQSFLAAVLLLHMPEEQAFCVLVKIM---YDYGLRDLYKNNFEDLHCKFYQLERLMQEQ 677
Query: 883 MPKLGEHFTQEMINPSMYASQWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLALLK 1062
+P L HF+ + MYASQWF+T+F+ FP I D+ L EG+ I+F V LALLK
Sbjct: 678 LPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLK 737
Query: 1063 HCHDDLVKLPFEELMHALR 1119
+DL++ FE + R
Sbjct: 738 TSKEDLLQADFEGALKFFR 756
>sp|A6H6A9|RBG1L_MOUSE Rab GTPase-activating protein 1-like OS=Mus musculus
GN=Rabgap1l PE=1 SV=1
Length = 815
Score = 176 bits (444), Expect = 6e-043
Identities = 97/259 (37%), Positives = 148/259 (57%), Gaps = 9/259 (3%)
Frame = +1
Query: 343 ERRVTKWRKMIGAGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNP 522
E+ + W +++G W + + +P + ++ G+P+ LR VWQL++G D M
Sbjct: 507 EKILYSWGELLGR----WHNNLGGRPKGLFTLVKSGVPEALRAEVWQLLAGCHDNQEMLD 562
Query: 523 GVYEQLVVYETSASELDIIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVGYV 702
++++ + SA E I RDI RTFP+H +F+ G GQ SLY + KAYSV+D D+GY
Sbjct: 563 KY--RILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVFDEDIGYC 620
Query: 703 QGMGFVAGLLLLYMSEEDAFWLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVREL 882
QG F+A +LLL+M EE AF +LV ++ G + LY+ + Q ++L++E
Sbjct: 621 QGQSFLAAVLLLHMPEEQAFCVLVTIMYG---YKLRDLYRNNFEDLHCKFYQLEKLMQEQ 677
Query: 883 MPKLGEHFTQEMINPSMYASQWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLALLK 1062
+P L HF + MYASQWF+T+F+ FP I D+ L EG+ I+F V LALLK
Sbjct: 678 LPDLYSHFCDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLK 737
Query: 1063 HCHDDLVKLPFEELMHALR 1119
+DL++ FE + R
Sbjct: 738 TSKEDLLQADFEGALKFFR 756
>sp|Q5ZJ17|RBG1L_CHICK Rab GTPase-activating protein 1-like OS=Gallus gallus
GN=RABGAP1L PE=2 SV=1
Length = 816
Score = 175 bits (443), Expect = 8e-043
Identities = 96/261 (36%), Positives = 150/261 (57%), Gaps = 13/261 (4%)
Frame = +1
Query: 343 ERRVTKWRKMIGAGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNP 522
E+ + W +++G W + + +P+ + +++G+P+ LR VWQL++G D N
Sbjct: 508 EKILYSWGELLGR----WHNNLVVRPNGLSTLVKRGVPEALRAEVWQLLAGCHD----NE 559
Query: 523 GVYE--QLVVYETSASELDIIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVG 696
+ + ++++ SA E I RDI RTFP+H +F+ G GQ SLY + KAYSVYD D+G
Sbjct: 560 AMLDKYRILITMDSAQENVITRDIHRTFPAHDYFKDTEGDGQESLYKICKAYSVYDEDIG 619
Query: 697 YVQGMGFVAGLLLLYMSEEDAFWLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVR 876
Y QG F+A +LLL+M EE AF + V ++ + LY+ + Q ++L++
Sbjct: 620 YCQGQSFLAAVLLLHMPEEQAFCVFVKIM---YDYGLRDLYRNNFEDLHCKFFQLEKLMQ 676
Query: 877 ELMPKLGEHFTQEMINPSMYASQWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLAL 1056
E +P L HF+ + MYASQWF+T+F+ FP I D+ L EG+ I+F V LAL
Sbjct: 677 EQLPDLYSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGMNIIFHVALAL 736
Query: 1057 LKHCHDDLVKLPFEELMHALR 1119
LK +DL++ FE + R
Sbjct: 737 LKTSKEDLLQADFEGALKFFR 757
>sp|P97366|EVI5_MOUSE Ecotropic viral integration site 5 protein OS=Mus musculus
GN=Evi5 PE=1 SV=2
Length = 809
Score = 169 bits (426), Expect = 7e-041
Identities = 104/333 (31%), Positives = 187/333 (56%), Gaps = 14/333 (4%)
Frame = +1
Query: 223 HRLIDLGFSSSRNTATILLNVSSRLIDHLPTMKSICLNWEERRVTKWRKMIGAGGSDWKH 402
+RLI+ S R+ N S L+ ++ + EE W +++ ++W
Sbjct: 93 NRLIETDSKSLRSVNGSRRNSGSSLVSSSSASSNLS-HLEEDSWILWGRIV----NEWDD 147
Query: 403 YVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNPGVYEQLVVYETSASELDIIR 582
++K VK +RKGIP R +VWQL+ ++ + + + Y +L+ TS E I R
Sbjct: 148 VRKKKEKQVKELVRKGIPHHFRAIVWQLLCNAQSMTIKDQ--YSELLKM-TSPCEKLIRR 204
Query: 583 DISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVGYVQGMGFVAGLLLLYMSEEDAF 762
DI+RT+P H FF+++ GQ L+NV+KAYS+ DR++ V+ + + M EE+AF
Sbjct: 205 DIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRELVTVRAVLSSLDCCCMQMPEEEAF 264
Query: 763 WLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVRELMPKLGEHFTQEMINPSMYAS 942
+ V L++ + L++ + + + QF+ +++E +P+L HF + + SMYAS
Sbjct: 265 CVFVKLMQ---DYRLRELFKPSMAELGLCMYQFECMIQEYLPELFVHFQSQSFHTSMYAS 321
Query: 943 QWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLALLKHCHDDLVKLPFEELMHALRN 1122
WF+T+F +FP A RI+D+F++EG+ IVF+VGLALL+ +L++L E ++ +
Sbjct: 322 SWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQK 381
Query: 1123 FPEDAMD--PDTLLPLAYSIKV-AKRLEEMKQD 1212
D P+ L+ AY +K +K++++++++
Sbjct: 382 VIPHQFDGGPEKLIQSAYQVKYNSKKMKKLEKE 414
>sp|Q80XC3|US6NL_MOUSE USP6 N-terminal-like protein OS=Mus musculus GN=Usp6nl
PE=1 SV=2
Length = 819
Score = 161 bits (407), Expect = 1e-038
Identities = 94/264 (35%), Positives = 143/264 (54%), Gaps = 13/264 (4%)
Frame = +1
Query: 340 EERRVTKWRKMIGAGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMN 519
E R +KW KM+ W+ Y + RRI KGIP LRG VW L+ +
Sbjct: 70 EIERTSKWLKML----KKWERY--KNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEET 123
Query: 520 PGVYEQLVVYETSAS----ELDIIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDR 687
+Y +L S ++D+ D++RTF H+ F+ R+G Q+SL++VL AYS+Y+
Sbjct: 124 RDLYSKLKHRARGCSPDIRQIDL--DVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNT 181
Query: 688 DVGYVQGMGFVAGLLLLYMSEEDAFWLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQ 867
+VGY QGM + LLL+YM+EEDAFW LV L G H+ M + G P + ++ ++
Sbjct: 182 EVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHA-MHGFFVQGFPKLLRFQEHHEK 240
Query: 868 LVRELMPKLGEHFTQEMINPSMYASQWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVG 1047
++ + + KL +H + I S Y +WF F PF LRIWD+++ EG ++ +
Sbjct: 241 ILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFRLNLRIWDIYIFEGERVLTAMS 300
Query: 1048 LALLKHCHDDLVKLPFEELMHALR 1119
+LK L+KL EEL+ L+
Sbjct: 301 YTILKLHKKHLMKLSMEELVEFLQ 324
>sp|Q92738|US6NL_HUMAN USP6 N-terminal-like protein OS=Homo sapiens GN=USP6NL
PE=1 SV=3
Length = 828
Score = 161 bits (405), Expect = 2e-038
Identities = 94/260 (36%), Positives = 141/260 (54%), Gaps = 13/260 (5%)
Frame = +1
Query: 340 EERRVTKWRKMIGAGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMN 519
E R TKW KM+ W+ Y + RRI KGIP LRG VW L+ +
Sbjct: 70 EIERTTKWLKML----KGWEKY--KNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEET 123
Query: 520 PGVYEQLVVYETSAS----ELDIIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDR 687
+Y +L S ++D+ D++RTF H+ F+ R+G Q+SL++VL AYS+Y+
Sbjct: 124 RDLYSKLKHRARGCSPDIRQIDL--DVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNT 181
Query: 688 DVGYVQGMGFVAGLLLLYMSEEDAFWLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQ 867
+VGY QGM + LLL+YM+EEDAFW LV L G H+ M + G P + ++ ++
Sbjct: 182 EVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHA-MHGFFVQGFPKLLRFQEHHEK 240
Query: 868 LVRELMPKLGEHFTQEMINPSMYASQWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVG 1047
++ + + KL +H + I S Y +WF F PF LRIWD+++ EG ++ +
Sbjct: 241 ILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMS 300
Query: 1048 LALLKHCHDDLVKLPFEELM 1107
+LK L+KL EEL+
Sbjct: 301 YTILKLHKKHLMKLSMEELV 320
>sp|Q86TI0|TBCD1_HUMAN TBC1 domain family member 1 OS=Homo sapiens GN=TBC1D1
PE=1 SV=2
Length = 1168
Score = 149 bits (375), Expect = 6e-035
Identities = 85/242 (35%), Positives = 134/242 (55%), Gaps = 14/242 (5%)
Frame = +1
Query: 355 TKWRKMIGAGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNPG--- 525
T W KM+ G + K H + +G+P RG +W+ ++ L P
Sbjct: 772 TVWEKMLSTPGRSKIKFDMEKMH---SAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQ 828
Query: 526 ----VYEQLVVYETSASELDIIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDV 693
Y++L+ TS I+ D+ RTFP+H +F + G GQ SLYN+LKAYS+ D++V
Sbjct: 829 PKDVPYKELLKQLTSQQHA-ILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEV 887
Query: 694 GYVQGMGFVAGLLLLYMSEEDAFWLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLV 873
GY QG+ FVAG+LLL+MSEE+AF +L L+ + Y+ + ++Q + Q +L+
Sbjct: 888 GYCQGLSFVAGILLLHMSEEEAFKMLKFLM---FDMGLRKQYRPDMIILQIQMYQLSRLL 944
Query: 874 RELMPKLGEHFTQEMINPSMYASQWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLA 1053
+ L H + I PS+YA+ WF+T+F+ FP R++D+ +G ++FKV L+
Sbjct: 945 HDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALS 1004
Query: 1054 LL 1059
LL
Sbjct: 1005 LL 1006
>sp|Q60949|TBCD1_MOUSE TBC1 domain family member 1 OS=Mus musculus GN=Tbc1d1
PE=2 SV=2
Length = 1255
Score = 149 bits (374), Expect = 8e-035
Identities = 86/242 (35%), Positives = 134/242 (55%), Gaps = 14/242 (5%)
Frame = +1
Query: 355 TKWRKMIGAGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNPG--- 525
T W KM+ G + K H + +G+P RG +W+ ++ L P
Sbjct: 859 TVWEKMLSTPGRSKIKFDMEKVH---SAVGQGVPRHHRGEIWKFLAEQFHLKHPFPSKQQ 915
Query: 526 ----VYEQLVVYETSASELDIIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDV 693
Y++L+ TS I+ D+ RTFP+H +F + G GQ SLYN+LKAYS+ D++V
Sbjct: 916 PKDVPYKELLKKLTSQQHA-ILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEV 974
Query: 694 GYVQGMGFVAGLLLLYMSEEDAFWLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLV 873
GY QG+ FVAG+LLL+MSEE+AF +L L+ + Y+ + ++Q + Q +L+
Sbjct: 975 GYCQGLSFVAGILLLHMSEEEAFKMLKFLM---FDMGLRKQYRPDMIILQIQMYQLSRLL 1031
Query: 874 RELMPKLGEHFTQEMINPSMYASQWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLA 1053
+ L H + I PS+YA+ WF+TVF+ FP R++D+ +G ++FKV L+
Sbjct: 1032 HDYHRDLYNHLEEHEIGPSLYAAPWFLTVFASQFPLGFVARVFDMIFLQGSEVIFKVALS 1091
Query: 1054 LL 1059
LL
Sbjct: 1092 LL 1093
>sp|O97790|TBCD1_BOVIN TBC1 domain family member 1 (Fragment) OS=Bos taurus
GN=TBC1D1 PE=2 SV=1
Length = 556
Score = 144 bits (362), Expect = 2e-033
Identities = 83/242 (34%), Positives = 133/242 (54%), Gaps = 14/242 (5%)
Frame = +1
Query: 355 TKWRKMIGAGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNP---- 522
T W K++ G + K H + +G+P RG +W+ ++ L P
Sbjct: 160 TVWEKILSTPGRSKIKFDMEKMH---SAVGQGVPRHHRGEIWKFLAEQYHLKHPFPCKQQ 216
Query: 523 ---GVYEQLVVYETSASELDIIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDV 693
Y++L+ TS I+ D+ RTFP+H ++ + G GQ SLYN+LKAYS+ D++V
Sbjct: 217 PKDTPYKELLKQLTSQQHA-ILIDLGRTFPTHPYYSAQLGAGQLSLYNILKAYSLLDQEV 275
Query: 694 GYVQGMGFVAGLLLLYMSEEDAFWLLVALLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLV 873
GY QG+ FVAG+LLL+M EE+AF +L L+ + Y+ + ++Q + Q +L+
Sbjct: 276 GYCQGLSFVAGILLLHMGEEEAFNMLKFLM---FDMGLRKQYRPDMIILQIQMYQLSRLL 332
Query: 874 RELMPKLGEHFTQEMINPSMYASQWFITVFSYSFPFHSALRIWDVFLAEGIIIVFKVGLA 1053
+ L H + I PS+YA+ WF+TVF+ FP R++D+ +G ++FKV L+
Sbjct: 333 HDYHRDLYNHLEEHEIGPSLYAAPWFLTVFASQFPLGFVARVFDMIFLQGSEVIFKVALS 392
Query: 1054 LL 1059
LL
Sbjct: 393 LL 394
>sp|O60343|TBCD4_HUMAN TBC1 domain family member 4 OS=Homo sapiens GN=TBC1D4
PE=1 SV=2
Length = 1298
Score = 144 bits (361), Expect = 3e-033
Identities = 81/235 (34%), Positives = 137/235 (58%), Gaps = 10/235 (4%)
Frame = +1
Query: 439 IRKGIPDCLRGLVWQLISGSRDL--LLMN----PGVYEQLVVYETSASELDIIRDISRTF 600
+++G+P RG +WQ ++ L L N P + + ++ + +A + I+ D+ RTF
Sbjct: 915 LKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTF 974
Query: 601 PSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVGYVQGMGFVAGLLLLYMSEEDAFWLLVAL 780
P+H +F + GPGQ SL+N+LKAYS+ D++VGY QG+ FVAG+LLL+MSEE AF +L L
Sbjct: 975 PTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFL 1034
Query: 781 LKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVRELMPKLGEHFTQEMINPSMYASQWFITV 960
+ Y+ + +Q + Q +L+ + L H + I+PS+YA+ WF+T+
Sbjct: 1035 M---YDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTL 1091
Query: 961 FSYSFPFHSALRIWDVFLAEGIIIVFKVGLALLKHCHDDLVKL-PFEELMHALRN 1122
F+ F R++D+ +G ++FKV L+LL +++ FE ++ L+N
Sbjct: 1092 FASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKN 1146
>sp|Q8BYJ6|TBCD4_MOUSE TBC1 domain family member 4 OS=Mus musculus GN=Tbc1d4
PE=1 SV=2
Length = 1307
Score = 143 bits (358), Expect = 6e-033
Identities = 75/213 (35%), Positives = 127/213 (59%), Gaps = 9/213 (4%)
Frame = +1
Query: 439 IRKGIPDCLRGLVWQLISGSRDLLLMNPGVYE------QLVVYETSASELDIIRDISRTF 600
+++G+P RG +WQ ++ L P ++ + ++ + +A + I+ D+ RTF
Sbjct: 924 LKEGVPKSRRGEIWQFLALQYRLRHRLPNKHQPPDTSYKELLKQLTAQQHAILVDLGRTF 983
Query: 601 PSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVGYVQGMGFVAGLLLLYMSEEDAFWLLVAL 780
P+H +F + G GQ SL+N+LKAYS+ D++VGY QG+ FVAG+LLL+MSEE AF +L L
Sbjct: 984 PTHPYFSVQLGAGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFL 1043
Query: 781 LKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVRELMPKLGEHFTQEMINPSMYASQWFITV 960
+ Y+ + +Q + Q +L+ + +L H + I+PS+YA+ WF+T+
Sbjct: 1044 M---YDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRELYNHLEENEISPSLYAAPWFLTL 1100
Query: 961 FSYSFPFHSALRIWDVFLAEGIIIVFKVGLALL 1059
F+ FP R++D+ +G ++FKV L+LL
Sbjct: 1101 FASQFPLGFVARVFDIIFLQGTEVIFKVALSLL 1133
>sp|Q12344|GYP5_YEAST GTPase-activating protein GYP5 OS=Saccharomyces cerevisiae
GN=GYP5 PE=1 SV=1
Length = 894
Score = 130 bits (325), Expect = 4e-029
Identities = 70/160 (43%), Positives = 101/160 (63%), Gaps = 4/160 (2%)
Frame = +1
Query: 646 SLYNVLKAYSVYDRDVGYVQGMGFVAGLLLLYM-SEEDAFWLLVALLKGAVHSPMEVLYQ 822
SLY V+K YSVYD DVGY QGMGF+A LL+ +E ++F LLV L+K + + L+
Sbjct: 507 SLYKVIKVYSVYDPDVGYTQGMGFIAAPLLINCENEAESFGLLVGLMK---NYGLRELFL 563
Query: 823 AGLPLVQKYLLQFDQLVRELMPKLGEHFTQEMINPSMYASQWFITVFSYSFPFHSALRIW 1002
G+P + L QFD+L+ E P L +E I+ +MYA+QWF+T F+Y FP LRI+
Sbjct: 564 PGMPGLMLMLYQFDRLLEEHSPSLYNRLIREGISSTMYATQWFLTFFAYKFPLEFVLRIF 623
Query: 1003 DVFLAEGIIIVFKVGLALLKHCHDDLVKLPFEELMHALRN 1122
D+ EGI ++ K + L+ + LVKL F+EL+ L++
Sbjct: 624 DIVFVEGIEVLLKFAVNLMLKNEETLVKLRFDELLDFLKD 663
>sp|Q8IZP1|TBC3A_HUMAN TBC1 domain family member 3 OS=Homo sapiens GN=TBC1D3
PE=2 SV=5
Length = 549
Score = 117 bits (291), Expect = 3e-025
Identities = 82/262 (31%), Positives = 124/262 (47%), Gaps = 9/262 (3%)
Frame = +1
Query: 244 FSSSRNTATILLNVSSRLIDHLPTMKSICLNWEERRVTKWRKMIGAGGSDWKHYVRRKPH 423
F S N L V + L ++ + E R +KW M+G DW+ Y +
Sbjct: 39 FRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLG----DWEKY--KSSR 92
Query: 424 VVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNPGVYEQLVVYETSASE--LDIIRDISRT 597
+ R KG+P +RG +W ++ ++ L NPG Y+ + +SE I RD+S T
Sbjct: 93 KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGT 152
Query: 598 FPSHVFFQKRHGPGQRSLYNVLKAYSVYDRDVGYVQGMGFVAGLLLLYMSEEDAFWLLVA 777
H+FF+ R+G QR L ++L AY Y+ +VGY + + +A L LLY+ EEDAFW LV
Sbjct: 153 LRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQ 212
Query: 778 LLKGAVHSPMEVLYQAGLPLVQKYLLQFDQLVRELMPKLGEHFTQEMINPSMYASQWFIT 957
LL HS ++ + VQ Q + +V PK H ++ + I
Sbjct: 213 LLASERHS-LQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIR 271
Query: 958 VFSYSFPFHSALRIWDVFLAEG 1023
+ LR+WDV+L EG
Sbjct: 272 ILIDGISLGLTLRLWDVYLVEG 293
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,263,552,948
Number of Sequences: 518415
Number of Extensions: 33263552948
Number of Successful Extensions: 238913225
Number of sequences better than 0.0: 0
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