BLASTX 7.6.2
Query= UN08579 /QuerySize=1319
(1318 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07943|ALDR_RAT Aldose reductase OS=Rattus norvegicus GN=Akr1... 252 4e-066
sp|P45376|ALDR_MOUSE Aldose reductase OS=Mus musculus GN=Akr1b1 ... 252 7e-066
sp|P15122|ALDR_RABIT Aldose reductase OS=Oryctolagus cuniculus G... 245 5e-064
sp|P16116|ALDR_BOVIN Aldose reductase OS=Bos taurus GN=AKR1B1 PE... 243 3e-063
sp|P15121|ALDR_HUMAN Aldose reductase OS=Homo sapiens GN=AKR1B1 ... 240 3e-062
sp|P80276|ALDR_PIG Aldose reductase OS=Sus scrofa GN=AKR1B1 PE=1... 239 4e-062
sp|Q9DCT1|AKCL2_MOUSE 1,5-anhydro-D-fructose reductase OS=Mus mu... 238 8e-062
sp|P82125|AKCL2_PIG 1,5-anhydro-D-fructose reductase OS=Sus scro... 236 2e-061
sp|Q5U1Y4|AKCL2_RAT 1,5-anhydro-D-fructose reductase OS=Rattus n... 236 4e-061
sp|P21300|ALD1_MOUSE Aldose reductase-related protein 1 OS=Mus m... 226 4e-058
sp|O08782|ALD2_CRIGR Aldose reductase-related protein 2 OS=Crice... 223 4e-057
sp|P45377|ALD2_MOUSE Aldose reductase-related protein 2 OS=Mus m... 220 2e-056
sp|O60218|AK1BA_HUMAN Aldo-keto reductase family 1 member B10 OS... 220 2e-056
sp|Q95JH7|AK1C1_MACFA Aldo-keto reductase family 1 member C1 hom... 215 8e-055
sp|Q04828|AK1C1_HUMAN Aldo-keto reductase family 1 member C1 OS=... 214 1e-054
sp|Q9P430|XYL1_CANSH NAD(P)H-dependent D-xylose reductase OS=Can... 127 2e-028
sp|O74237|XYL1_CANTE NAD(P)H-dependent D-xylose reductase OS=Can... 127 2e-028
sp|O13283|XYL1_CANTR NAD(P)H-dependent D-xylose reductase I,II O... 126 5e-028
sp|P87039|XYL2_CANTR NADPH-dependent D-xylose reductase II,III O... 125 8e-028
sp|Q4R802|AKCL2_MACFA 1,5-anhydro-D-fructose reductase OS=Macaca... 124 2e-027
>sp|P07943|ALDR_RAT Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3
Length = 316
Score = 252 bits (643), Expect = 4e-066
Identities = 131/279 (46%), Positives = 182/279 (65%), Gaps = 12/279 (4%)
Frame = -3
Query: 1079 ELNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLCEK 900
ELN G K+P++GLGTW++ PG V +AV A+ +GYRHIDCAQ+Y NEKE+G AL++ ++
Sbjct: 6 ELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKE 65
Query: 899 GVVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVGV-- 726
VVKR++LFI SKLWCT HD V A +T+ LQLDY+DLYLIHWP K G
Sbjct: 66 QVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPL 125
Query: 725 -SPENLLP--VDIPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--ARVPPAVNQV 561
+ N++P D +TW +ME L D G +AIGVSNF+ ++ +L+ + PAVNQ+
Sbjct: 126 DASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQI 185
Query: 560 ECHPSWRQAKLREFCKSKGVHLSAYFPLGSPG--WSHSD---VLKNPILNKVAEKLGKSP 396
ECHP Q KL E+C KG+ ++AY PLGSP W+ + +L++P + ++A K K+
Sbjct: 186 ECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTT 245
Query: 395 AQVALCWGLQMGHSVLPKSTNEGRIRENLDVFDWSIPNE 279
AQV + + +Q V+PKS RI EN VFD+ + NE
Sbjct: 246 AQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNE 284
>sp|P45376|ALDR_MOUSE Aldose reductase OS=Mus musculus GN=Akr1b1 PE=1 SV=3
Length = 316
Score = 252 bits (641), Expect = 7e-066
Identities = 131/279 (46%), Positives = 182/279 (65%), Gaps = 12/279 (4%)
Frame = -3
Query: 1079 ELNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLCEK 900
ELN G K+P++GLGTW++ PG V +AV A+ +GYRHIDCAQ+Y NEKE+G AL++ ++
Sbjct: 6 ELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDLGYRHIDCAQVYQNEKEVGVALQEKLKE 65
Query: 899 GVVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVGV-- 726
VVKR++LFI SKLWCT HD V A +T+ LQLDY+DLYLIHWP K G
Sbjct: 66 QVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPL 125
Query: 725 -SPENLLP--VDIPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--ARVPPAVNQV 561
+ N++P D +TW +ME L D G + IGVSNF+ ++ +L+ + PAVNQ+
Sbjct: 126 DASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQI 185
Query: 560 ECHPSWRQAKLREFCKSKGVHLSAYFPLGSPG--WSHSD---VLKNPILNKVAEKLGKSP 396
ECHP Q KL E+C SKG+ ++AY PLGSP W+ + +L++P + +A K K+
Sbjct: 186 ECHPYLTQEKLIEYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTT 245
Query: 395 AQVALCWGLQMGHSVLPKSTNEGRIRENLDVFDWSIPNE 279
AQV + + +Q V+PKS RI ENL VFD+ + +E
Sbjct: 246 AQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSE 284
>sp|P15122|ALDR_RABIT Aldose reductase OS=Oryctolagus cuniculus GN=AKR1B1 PE=2
SV=3
Length = 316
Score = 245 bits (625), Expect = 5e-064
Identities = 128/278 (46%), Positives = 181/278 (65%), Gaps = 12/278 (4%)
Frame = -3
Query: 1076 LNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLCEKG 897
L GAK+P +GLGTW++ PG V +AV A+ +GYRHIDCA +Y NE E+G AL++ ++
Sbjct: 7 LYNGAKMPILGLGTWKSPPGQVTEAVKTAIDLGYRHIDCAHVYQNENEVGVALQEKLKEQ 66
Query: 896 VVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVGV--- 726
VVKREELFI SKLWCT HD V A +T+ L+LDY+DLYLIHWP K GS
Sbjct: 67 VVKREELFIVSKLWCTSHDKSLVKGACQKTLNDLKLDYLDLYLIHWPTGFKHGSEYFPLD 126
Query: 725 SPENLLP--VDIPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--ARVPPAVNQVE 558
+ N++P D +TW++ME L D G ++IGVSNF+ ++ +L+ + PAVNQ+E
Sbjct: 127 AAGNVIPSDTDFLDTWEAMEGLVDEGLVKSIGVSNFNHLQIERILNKPGLKYKPAVNQIE 186
Query: 557 CHPSWRQAKLREFCKSKGVHLSAYFPLGSPG--WSHSD---VLKNPILNKVAEKLGKSPA 393
CHP Q KL ++C SKG+ ++AY PLGSP W+ + +L++P + +A+K K+ A
Sbjct: 187 CHPYLTQEKLIQYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIADKHKKTTA 246
Query: 392 QVALCWGLQMGHSVLPKSTNEGRIRENLDVFDWSIPNE 279
QV + + +Q V+PKS RI EN VFD+ + +E
Sbjct: 247 QVLIRFPMQRNLVVIPKSVTPARIAENFQVFDFELSSE 284
>sp|P16116|ALDR_BOVIN Aldose reductase OS=Bos taurus GN=AKR1B1 PE=1 SV=1
Length = 315
Score = 243 bits (619), Expect = 3e-063
Identities = 128/278 (46%), Positives = 178/278 (64%), Gaps = 12/278 (4%)
Frame = -3
Query: 1076 LNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLCEKG 897
L TGAK+P +GLGTW++ PG V +AV A+ +GYRHIDCA +Y NE E+G AL+ ++
Sbjct: 6 LYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQ 65
Query: 896 VVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVGVSPE 717
VVKRE+LFI SKLWCT HD V A +T+ L+LDY+DLYLIHWP K G +
Sbjct: 66 VVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLD 125
Query: 716 ---NLLP--VDIPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--ARVPPAVNQVE 558
N++P D +TW +ME L D G +AIGVSNF+ ++ +L+ + PAVNQ+E
Sbjct: 126 EDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIE 185
Query: 557 CHPSWRQAKLREFCKSKGVHLSAYFPLGSPG--WSHSD---VLKNPILNKVAEKLGKSPA 393
CHP Q KL ++C SKG+ ++AY PLGSP W+ + +L++P + +A+K K+ A
Sbjct: 186 CHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTA 245
Query: 392 QVALCWGLQMGHSVLPKSTNEGRIRENLDVFDWSIPNE 279
QV + + +Q V+PKS RI EN VFD+ + E
Sbjct: 246 QVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKE 283
>sp|P15121|ALDR_HUMAN Aldose reductase OS=Homo sapiens GN=AKR1B1 PE=1 SV=3
Length = 316
Score = 240 bits (610), Expect = 3e-062
Identities = 126/278 (45%), Positives = 180/278 (64%), Gaps = 12/278 (4%)
Frame = -3
Query: 1076 LNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLCEKG 897
LN GAK+P +GLGTW++ PG V +AV A+ +GYRHIDCA +Y NE E+G A+++ +
Sbjct: 7 LNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQ 66
Query: 896 VVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVGVSPE 717
VVKREELFI SKLWCT H+ V A +T+ L+LDY+DLYLIHWP K G +
Sbjct: 67 VVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLD 126
Query: 716 ---NLLPVD--IPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--ARVPPAVNQVE 558
N++P D I +TW +ME L D G +AIG+SNF+ ++ +L+ + PAVNQ+E
Sbjct: 127 ESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIE 186
Query: 557 CHPSWRQAKLREFCKSKGVHLSAYFPLGSPG--WSHSD---VLKNPILNKVAEKLGKSPA 393
CHP Q KL ++C+SKG+ ++AY PLGSP W+ + +L++P + +A K K+ A
Sbjct: 187 CHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTA 246
Query: 392 QVALCWGLQMGHSVLPKSTNEGRIRENLDVFDWSIPNE 279
QV + + +Q V+PKS RI EN VFD+ + ++
Sbjct: 247 QVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQ 284
>sp|P80276|ALDR_PIG Aldose reductase OS=Sus scrofa GN=AKR1B1 PE=1 SV=2
Length = 316
Score = 239 bits (609), Expect = 4e-062
Identities = 128/278 (46%), Positives = 177/278 (63%), Gaps = 12/278 (4%)
Frame = -3
Query: 1076 LNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLCEKG 897
L TGAK+P +GLGTW++ PG V +AV A+ +GYRHIDCA +Y NE E+G L++ +
Sbjct: 7 LYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEKLQGQ 66
Query: 896 VVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVGVSPE 717
VVKRE+LFI SKLWCTDH+ V A T++ L+LDY+DLYLIHWP K G +
Sbjct: 67 VVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPFPLD 126
Query: 716 ---NLLP--VDIPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--ARVPPAVNQVE 558
N++P D TW++ME L D G +AIGVSNF+ ++ +L+ + PAVNQ+E
Sbjct: 127 GDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIE 186
Query: 557 CHPSWRQAKLREFCKSKGVHLSAYFPLGSPG--WSHSD---VLKNPILNKVAEKLGKSPA 393
HP Q KL E+CKSKG+ ++AY PLGSP W+ + +L++P + +A K K+ A
Sbjct: 187 VHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTA 246
Query: 392 QVALCWGLQMGHSVLPKSTNEGRIRENLDVFDWSIPNE 279
QV + + +Q V+PKS RI EN VFD+ + E
Sbjct: 247 QVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPE 284
>sp|Q9DCT1|AKCL2_MOUSE 1,5-anhydro-D-fructose reductase OS=Mus musculus
GN=Akr1e2 PE=1 SV=1
Length = 301
Score = 238 bits (606), Expect = 8e-062
Identities = 121/264 (45%), Positives = 169/264 (64%), Gaps = 8/264 (3%)
Frame = -3
Query: 1058 IPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLCEKGVVKREE 879
IP+VGLGTW+ASPG V DAV A+ +GYRH DCA LY NE E+G + + ++GVVKRE+
Sbjct: 4 IPTVGLGTWKASPGEVTDAVKLAINLGYRHFDCAYLYHNESEVGMGISEKIKEGVVKRED 63
Query: 878 LFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVGVSPE---NLL 708
LF+ SKLWCT H V A T+++L LDY+DLYLIHWP+ K G + + ++
Sbjct: 64 LFVVSKLWCTCHKKSLVKTACTNTLEALNLDYLDLYLIHWPMGFKPGEKDIPLDRNGKVI 123
Query: 707 P--VDIPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--ARVPPAVNQVECHPSWR 540
P +TW++ME L G + +GVSNF+ ++L LLD RV P NQ+ECHP
Sbjct: 124 PSHTSFLDTWEAMEDLVFEGLVKNLGVSNFNHEQLERLLDKPGLRVRPITNQIECHPYLN 183
Query: 539 QAKLREFCKSKGVHLSAYFPLGSPGWSHSDVLKNPILNKVAEKLGKSPAQVALCWGLQMG 360
Q KL +FC + V ++AY PLG G ++ + ++ K+A+K GKSPAQ+ + + +Q
Sbjct: 184 QKKLIDFCHKRNVSVTAYRPLGGSGGGF-HLMDDTVIRKIAKKHGKSPAQILIRFQIQRN 242
Query: 359 HSVLPKSTNEGRIRENLDVFDWSI 288
V+PKS RIREN+ VFD+ +
Sbjct: 243 LIVIPKSVTPSRIRENIQVFDFEL 266
>sp|P82125|AKCL2_PIG 1,5-anhydro-D-fructose reductase OS=Sus scrofa GN=AKR1E2
PE=1 SV=2
Length = 301
Score = 236 bits (602), Expect = 2e-061
Identities = 124/284 (43%), Positives = 175/284 (61%), Gaps = 8/284 (2%)
Frame = -3
Query: 1061 KIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLCEKGVVKRE 882
KIP +GLGTWQA+PG V +AV A+ GYRH DCA LY NE E+G ++ ++GVV+RE
Sbjct: 3 KIPVLGLGTWQAAPGEVTEAVKVAIDTGYRHFDCAYLYHNENEVGVGIQAKIDEGVVRRE 62
Query: 881 ELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVGVSPEN---- 714
+LFI SKLWCT H V A R++++L+L Y+DLYLIHWP+ K G V + +
Sbjct: 63 DLFIVSKLWCTCHKKSLVKSACTRSLKALKLQYLDLYLIHWPMGFKPGEVDLPVDRSGMI 122
Query: 713 -LLPVDIPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--ARVPPAVNQVECHPSW 543
D +TW++ME L G RAIGVSNF+ ++L LL+ RV P NQ+ECHP
Sbjct: 123 VASNTDFLDTWEAMEDLVIEGLVRAIGVSNFNHEQLERLLNKPNLRVKPVTNQIECHPYL 182
Query: 542 RQAKLREFCKSKGVHLSAYFPLGSPGWSHSDVLKNPILNKVAEKLGKSPAQVALCWGLQM 363
Q KL FC+S+ V ++AY PLG +L++P++ +A+K GKS AQ+ + + +Q
Sbjct: 183 TQKKLISFCQSRNVSVTAYRPLGGSS-EGVPLLEDPVIQTIAQKHGKSAAQILIRFQIQR 241
Query: 362 GHSVLPKSTNEGRIRENLDVFDWSIPNELFAKFSDIEQTRLLNA 231
V+PKS N RI EN VFD+ + + +++ L+A
Sbjct: 242 NVIVIPKSVNPKRILENFQVFDFELSEQDMTDLLGLDRNLRLSA 285
>sp|Q5U1Y4|AKCL2_RAT 1,5-anhydro-D-fructose reductase OS=Rattus norvegicus
GN=Akr1e2 PE=2 SV=1
Length = 301
Score = 236 bits (600), Expect = 4e-061
Identities = 126/295 (42%), Positives = 182/295 (61%), Gaps = 9/295 (3%)
Frame = -3
Query: 1061 KIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLCEKGVVKRE 882
+IP+VGLGTW+ASPG V DAV A+ +GYRH DCA LY NE E+G +K+ ++GVVKR+
Sbjct: 3 QIPTVGLGTWKASPGEVTDAVKVAINLGYRHFDCAYLYHNESEVGMGIKEKIKEGVVKRD 62
Query: 881 ELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVGVSPE---NL 711
ELFI SKLWCT H V A T+++L LDY+DLYLIHWP+ K G + + +
Sbjct: 63 ELFIVSKLWCTYHKQSLVKTACINTLEALNLDYLDLYLIHWPMGFKPGDKDIPLDRSGKV 122
Query: 710 LP--VDIPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--ARVPPAVNQVECHPSW 543
+P +TW++ME L G + IGVSNF+ ++L LL+ R+ P NQ+ECHP
Sbjct: 123 IPSHTSFLDTWEAMEDLVIEGLVKNIGVSNFNHEQLDRLLNKPGLRIKPITNQIECHPYL 182
Query: 542 RQAKLREFCKSKGVHLSAYFPLGSPGWSHSDVLKNPILNKVAEKLGKSPAQVALCWGLQM 363
Q L +FC + V ++AY PLG ++ + ++ K+A+K GKSPAQ+ + + +Q
Sbjct: 183 NQKSLIDFCHGRNVSVTAYRPLGG-SRDGVHLMDDIVIRKIAKKHGKSPAQILIRFQIQR 241
Query: 362 GHSVLPKSTNEGRIRENLDVFDWSIPNELFAKFSDIEQTRLLNASFFAHETLSPY 198
V+PKS N RIREN+ VFD+ + + + +++ L A+F + E Y
Sbjct: 242 NLIVIPKSVNPSRIRENIQVFDFELTEKDMEELLSLDKNLRL-ATFPSTENHKDY 295
>sp|P21300|ALD1_MOUSE Aldose reductase-related protein 1 OS=Mus musculus
GN=Akr1b7 PE=2 SV=4
Length = 316
Score = 226 bits (574), Expect = 4e-058
Identities = 119/281 (42%), Positives = 176/281 (62%), Gaps = 12/281 (4%)
Frame = -3
Query: 1085 FFELNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLC 906
F EL+T AK+P VGLGTW++SPG V +AV AA+ GYRHIDCA +Y NE E+G A+++
Sbjct: 4 FVELSTKAKMPLVGLGTWKSSPGQVKEAVKAAIDAGYRHIDCAYVYHNENEVGEAIQEKI 63
Query: 905 EKGVVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVGV 726
++ VKRE+LFI SKLW T + V +A T+ L+LDY+DLYL+HWP + G+ +
Sbjct: 64 KENAVKREDLFIVSKLWATFFEKSLVKKAFQNTLSDLKLDYLDLYLVHWPQGFQAGNALL 123
Query: 725 SPEN-----LLPVDIPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--ARVPPAVN 567
+N L + W++ME L D G +A+G+SNF+ ++ LL+ + P N
Sbjct: 124 PKDNKGKVLLSKSTFLDAWEAMEELVDQGLVKALGISNFNHFQIERLLNKPGLKHKPVTN 183
Query: 566 QVECHPSWRQAKLREFCKSKGVHLSAYFPLGSPGWSHSD-----VLKNPILNKVAEKLGK 402
Q+E HP Q KL ++C+SKG+ ++AY PLGSP ++ V++ P + ++A K K
Sbjct: 184 QIESHPYLTQEKLIQYCQSKGIAVTAYSPLGSPDRPYAKPEDPVVMEIPKIKEIAAKHKK 243
Query: 401 SPAQVALCWGLQMGHSVLPKSTNEGRIRENLDVFDWSIPNE 279
+ AQV + + +Q V+PKS RI+ENL VFD+ + E
Sbjct: 244 TVAQVLIRFHVQRNVVVIPKSVTPSRIQENLQVFDFQLSEE 284
>sp|O08782|ALD2_CRIGR Aldose reductase-related protein 2 OS=Cricetulus griseus
GN=AKR1B8 PE=1 SV=3
Length = 316
Score = 223 bits (566), Expect = 4e-057
Identities = 122/284 (42%), Positives = 177/284 (62%), Gaps = 12/284 (4%)
Frame = -3
Query: 1085 FFELNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLC 906
F EL+T AK+P VGLGTWQ+ PG V +AV A+ GYRHIDCA Y NE E+G A+++
Sbjct: 4 FVELSTKAKMPIVGLGTWQSPPGQVKEAVKVAIDAGYRHIDCAYAYYNEHEVGEAIQEKI 63
Query: 905 EKGVVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVGV 726
++ V+RE+LFI SKLW T + + + EA +T+ L+LDY+DLYLIHWP ++ G
Sbjct: 64 KEKAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKELF 123
Query: 725 SPE---NLLPVDIP--NTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--ARVPPAVN 567
+ N+L I + W+ ME L D G +A+GVSNF+ ++ +L+ + P N
Sbjct: 124 PKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHKPVTN 183
Query: 566 QVECHPSWRQAKLREFCKSKGVHLSAYFPLGSPG--WSHSD---VLKNPILNKVAEKLGK 402
QVECHP Q KL E+C SKG+ ++AY PLGSP W+ + +L++P + ++A K K
Sbjct: 184 QVECHPYLTQEKLIEYCHSKGITVTAYSPLGSPNRPWAKPEDPSLLEDPKIKEIAAKHKK 243
Query: 401 SPAQVALCWGLQMGHSVLPKSTNEGRIRENLDVFDWSIPNELFA 270
+ AQV + + +Q V+PKS RI EN VFD+ + ++ A
Sbjct: 244 TSAQVLIRFHIQRNVVVIPKSVTPARIHENFQVFDFQLSDQEMA 287
>sp|P45377|ALD2_MOUSE Aldose reductase-related protein 2 OS=Mus musculus
GN=Akr1b8 PE=1 SV=2
Length = 316
Score = 220 bits (560), Expect = 2e-056
Identities = 121/290 (41%), Positives = 175/290 (60%), Gaps = 24/290 (8%)
Frame = -3
Query: 1085 FFELNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLC 906
F EL+T AK+P VGLGTW++ P V +AV AA+ GYRHIDCA Y NE E+G A+++
Sbjct: 4 FVELSTKAKMPIVGLGTWKSPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQEKI 63
Query: 905 EKGVVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVGV 726
++ V+RE+LFI SKLW T + + + EA +T+ L+LDY+DLYLIHWP ++ G
Sbjct: 64 KEKAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPG---- 119
Query: 725 SPENLLPVD-----------IPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--AR 585
+ L P D W+ ME L D G +A+GVSNF+ ++ LL+ +
Sbjct: 120 --KELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLK 177
Query: 584 VPPAVNQVECHPSWRQAKLREFCKSKGVHLSAYFPLGSPGWSHS-----DVLKNPILNKV 420
P NQVECHP Q KL ++C SKG+ ++AY PLGSP + +L++P + ++
Sbjct: 178 HKPVTNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSPDRPSAKPEDPSLLEDPKIKEI 237
Query: 419 AEKLGKSPAQVALCWGLQMGHSVLPKSTNEGRIRENLDVFDWSIPNELFA 270
A K K+ AQV + + +Q V+PKS RI+EN+ VFD+ + +E A
Sbjct: 238 AAKHEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMA 287
>sp|O60218|AK1BA_HUMAN Aldo-keto reductase family 1 member B10 OS=Homo sapiens
GN=AKR1B10 PE=1 SV=1
Length = 316
Score = 220 bits (559), Expect = 2e-056
Identities = 122/290 (42%), Positives = 177/290 (61%), Gaps = 24/290 (8%)
Frame = -3
Query: 1085 FFELNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLC 906
F EL+T AK+P VGLGTW++ G V +AV A+ GYRHIDCA +Y NE E+G A+++
Sbjct: 4 FVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKI 63
Query: 905 EKGVVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVGV 726
++ VKRE+LFI SKLW T + V +A +T++ L+L Y+D+YLIHWP K G
Sbjct: 64 QEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSG---- 119
Query: 725 SPENLLPVD-----------IPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--AR 585
++L P D + W++ME L D G +A+GVSNFS ++ LL+ +
Sbjct: 120 --DDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLK 177
Query: 584 VPPAVNQVECHPSWRQAKLREFCKSKGVHLSAYFPLGSPG--WSHSD---VLKNPILNKV 420
P NQVECHP Q KL ++C SKG+ ++AY PLGSP W+ + +L++P + ++
Sbjct: 178 YKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEI 237
Query: 419 AEKLGKSPAQVALCWGLQMGHSVLPKSTNEGRIRENLDVFDWSIPNELFA 270
A K K+ AQV + + +Q V+PKS RI EN+ VFD+ + +E A
Sbjct: 238 AAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMA 287
>sp|Q95JH7|AK1C1_MACFA Aldo-keto reductase family 1 member C1 homolog OS=Macaca
fascicularis GN=AKR1C1 PE=1 SV=1
Length = 323
Score = 215 bits (546), Expect = 8e-055
Identities = 128/317 (40%), Positives = 186/317 (58%), Gaps = 29/317 (9%)
Frame = -3
Query: 1079 ELNTGAKIPSVGLGTW---QASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKL 909
+LN G +P +G GT+ + +A A++ G+RHID A LY NE+ +G A++
Sbjct: 9 KLNDGHFMPVLGFGTYAPAEVPKNKALEATKLAIEAGFRHIDSAHLYNNEEYVGLAIRSK 68
Query: 908 CEKGVVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMKKGSVG 729
G VKRE++F TSKLWC H P+ V AL R++++LQLDYVDLYLIH+PV +K G
Sbjct: 69 IADGTVKREDIFYTSKLWCNSHRPEFVRPALERSLKNLQLDYVDLYLIHFPVSLKPG--- 125
Query: 728 VSPENLLP-----------VDIPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL--A 588
E L+P VD+ TW++ME D+G A++IGVSNF+ ++L +L+
Sbjct: 126 ---EELIPKDENGKLLFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGL 182
Query: 587 RVPPAVNQVECHPSWRQAKLREFCKSKGVHLSAYFPLGS---PGWSHSD---VLKNPILN 426
+ P NQVECHP Q KL +FCKSK + L A+ LGS W + +L++P+L
Sbjct: 183 KYKPVCNQVECHPYLNQRKLLDFCKSKDIVLVAFSALGSHREKPWVDQNSPVLLEDPVLC 242
Query: 425 KVAEKLGKSPAQVALCWGLQMGHSVLPKSTNEGRIRENLDVFDWSIPNELFAKFSDIEQT 246
+A+K ++PA +AL + LQ G VL KS NE RIREN+ VF++ + +E +++
Sbjct: 243 ALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENMKVFEFQLTSEDMKAIDGLDRN 302
Query: 245 -RLLNASFFAHETLSPY 198
R L FA P+
Sbjct: 303 IRYLTLDIFAGPPNYPF 319
>sp|Q04828|AK1C1_HUMAN Aldo-keto reductase family 1 member C1 OS=Homo sapiens
GN=AKR1C1 PE=1 SV=1
Length = 323
Score = 214 bits (544), Expect = 1e-054
Identities = 125/319 (39%), Positives = 188/319 (58%), Gaps = 17/319 (5%)
Frame = -3
Query: 1103 MSNALRFFELNTGAKIPSVGLGTW---QASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKE 933
M + + +LN G +P +G GT+ + +A A++ G+RHID A LY NE++
Sbjct: 1 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ 60
Query: 932 IGTALKKLCEKGVVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPV 753
+G A++ G VKRE++F TSKLWC H P+ V AL R++++LQLDYVDLYLIH+PV
Sbjct: 61 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 120
Query: 752 RMKKGSVGVSPEN-----LLPVDIPNTWKSMEALYDSGKARAIGVSNFSTKKLGNLLDL- 591
+K G + + VD+ TW+++E D+G A++IGVSNF+ ++L +L+
Sbjct: 121 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP 180
Query: 590 -ARVPPAVNQVECHPSWRQAKLREFCKSKGVHLSAYFPLGS---PGWSHSD---VLKNPI 432
+ P NQVECHP + Q KL +FCKSK + L AY LGS W + +L++P+
Sbjct: 181 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 240
Query: 431 LNKVAEKLGKSPAQVALCWGLQMGHSVLPKSTNEGRIRENLDVFDWSIPNELFAKFSDIE 252
L +A+K ++PA +AL + LQ G VL KS NE RIR+N+ VF++ + +E +
Sbjct: 241 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 300
Query: 251 Q-TRLLNASFFAHETLSPY 198
+ R L FA P+
Sbjct: 301 RNVRYLTLDIFAGPPNYPF 319
>sp|Q9P430|XYL1_CANSH NAD(P)H-dependent D-xylose reductase OS=Candida shehatae
GN=XYL1 PE=3 SV=1
Length = 323
Score = 127 bits (318), Expect = 2e-028
Identities = 55/113 (48%), Positives = 81/113 (71%)
Frame = -3
Query: 1082 FELNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLCE 903
F+LN G ++PS+G G W+ D V A+K GYR D A+ YGNE+E+G +K+ +
Sbjct: 9 FKLNNGLEMPSIGFGCWKLDKSTAADQVYNAIKAGYRLFDGAEDYGNEQEVGEGVKRAID 68
Query: 902 KGVVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMK 744
+G+V REE+F+TSKLW HDP++V ALN+T++ L++DYVDL+LIH+P+ K
Sbjct: 69 EGIVTREEIFLTSKLWNNYHDPKNVETALNKTLKDLKVDYVDLFLIHFPIAFK 121
>sp|O74237|XYL1_CANTE NAD(P)H-dependent D-xylose reductase OS=Candida tenuis
GN=XYL1 PE=1 SV=1
Length = 322
Score = 127 bits (318), Expect = 2e-028
Identities = 57/120 (47%), Positives = 86/120 (71%)
Frame = -3
Query: 1103 MSNALRFFELNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGT 924
MS ++ +L++G +PS+G G W+ + G+ V A+K GYR D A+ YGNEKE+G
Sbjct: 1 MSASIPDIKLSSGHLMPSIGFGCWKLANATAGEQVYQAIKAGYRLFDGAEDYGNEKEVGD 60
Query: 923 ALKKLCEKGVVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMK 744
+K+ ++G+VKREE+F+TSKLW HDP++V ALN+T+ L++DYVDL+LIH+P+ K
Sbjct: 61 GVKRAIDEGLVKREEIFLTSKLWNNYHDPKNVETALNKTLADLKVDYVDLFLIHFPIAFK 120
>sp|O13283|XYL1_CANTR NAD(P)H-dependent D-xylose reductase I,II OS=Candida
tropicalis GN=xyrA PE=3 SV=1
Length = 324
Score = 126 bits (315), Expect = 5e-028
Identities = 57/112 (50%), Positives = 79/112 (70%)
Frame = -3
Query: 1079 ELNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLCEK 900
+LN+G ++P VG G W+ + D + A+K GYR D A+ YGNEKE+G + + ++
Sbjct: 11 KLNSGYEMPLVGFGCWKVTNATAADQIYNAIKTGYRLFDGAEDYGNEKEVGEGINRAIKE 70
Query: 899 GVVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMK 744
G+VKREELFITSKLW HDP++V ALN+T+ L LDYVDL+LIH+P+ K
Sbjct: 71 GLVKREELFITSKLWNNFHDPKNVETALNKTLSDLNLDYVDLFLIHFPIAFK 122
>sp|P87039|XYL2_CANTR NADPH-dependent D-xylose reductase II,III OS=Candida
tropicalis GN=xyrB PE=1 SV=1
Length = 324
Score = 125 bits (313), Expect = 8e-028
Identities = 57/112 (50%), Positives = 79/112 (70%)
Frame = -3
Query: 1079 ELNTGAKIPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLCEK 900
+LN+G ++P VG G W+ + D + A+K GYR D A+ YGNEKE+G + + ++
Sbjct: 11 KLNSGYEMPLVGFGCWKVNNETAADQIYNAIKTGYRLFDGAEDYGNEKEVGEGINRAIKE 70
Query: 899 GVVKREELFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMK 744
G+VKREELFITSKLW HDP++V ALN+T+ L LDYVDL+LIH+P+ K
Sbjct: 71 GLVKREELFITSKLWNNFHDPKNVETALNKTLSDLNLDYVDLFLIHFPIAFK 122
>sp|Q4R802|AKCL2_MACFA 1,5-anhydro-D-fructose reductase OS=Macaca fascicularis
GN=AKR1E2 PE=2 SV=1
Length = 320
Score = 124 bits (310), Expect = 2e-027
Identities = 55/105 (52%), Positives = 75/105 (71%)
Frame = -3
Query: 1058 IPSVGLGTWQASPGVVGDAVAAAVKIGYRHIDCAQLYGNEKEIGTALKKLCEKGVVKREE 879
IP+VGL W+ASPG V +AV A+ GYRH +CA Y NEKE+G ++ ++G V+RE+
Sbjct: 4 IPAVGLSCWKASPGKVTEAVKVAIDAGYRHFNCAYFYHNEKEVGAGIRYKIKEGAVRRED 63
Query: 878 LFITSKLWCTDHDPQDVPEALNRTIQSLQLDYVDLYLIHWPVRMK 744
LFI SKLWCT H V A R++++L+L+Y+DLYLIHWP+ K
Sbjct: 64 LFIASKLWCTCHKKSLVKTACRRSLKALKLNYLDLYLIHWPMGFK 108
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,801,685,782
Number of Sequences: 518415
Number of Extensions: 36801685782
Number of Successful Extensions: 258262551
Number of sequences better than 0.0: 0
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