BLASTX 7.6.2
Query= UN08753 /QuerySize=1444
(1443 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q99PV0|PRP8_MOUSE Pre-mRNA-processing-splicing factor 8 OS=Mu... 653 9e-187
sp|Q6P2Q9|PRP8_HUMAN Pre-mRNA-processing-splicing factor 8 OS=Ho... 651 4e-186
sp|P34369|PRP8_CAEEL Pre-mRNA-splicing factor 8 homolog OS=Caeno... 620 9e-177
sp|Q8T295|PRP8_DICDI Pre-mRNA-processing-splicing factor 8 homol... 560 1e-158
sp|O14187|SPP42_SCHPO Pre-mRNA-splicing factor spp42 OS=Schizosa... 492 3e-138
sp|P33334|PRP8_YEAST Pre-mRNA-splicing factor 8 OS=Saccharomyces... 363 2e-099
>sp|Q99PV0|PRP8_MOUSE Pre-mRNA-processing-splicing factor 8 OS=Mus musculus
GN=Prpf8 PE=1 SV=2
Length = 2335
Score = 653 bits (1684), Expect = 9e-187
Identities = 296/409 (72%), Positives = 354/409 (86%)
Frame = -3
Query: 1441 ISSYTAFSRLILILRALHVNNEKAKMLLKPDKSVVTEPHHIWPSLTDDQWMKVEVALRDL 1262
ISSYTAFSRLILILRALHVNN++AK++LKPDK+ VTEPHHIWP+LTD++W+KVEV L+DL
Sbjct: 1927 ISSYTAFSRLILILRALHVNNDRAKVILKPDKTTVTEPHHIWPTLTDEEWIKVEVQLKDL 1986
Query: 1261 ILSDYAKKNNVNTSALTQSEIRDIILGAEITPPSQQRQQIAEIEKQAKEASQLNAVTTRT 1082
IL+DY KKNNVN ++LTQSEIRDIILG EI+ PSQQRQQIAEIEKQ KE SQL A TRT
Sbjct: 1987 ILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLTATQTRT 2046
Query: 1081 TNVHGEELIVTTTSPYEQTAFGSKTDWRVRAISATNLYLRVNHIYVNSDDIKETGYTYIM 902
N HG+E+I +TTS YE F SKT+WRVRAISA NL+LR NHIYV+SDDIKETGYTYI+
Sbjct: 2047 VNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYIL 2106
Query: 901 PKNILKKLICVADLRTQIAGYLYGISPPDNPQVKEIRCVVMVPQWGSHQHVNLPSALPEH 722
PKN+LKK IC++DLR QIAGYLYG+SPPDNPQVKEIRC+VMVPQWG+HQ V+LPS LP+H
Sbjct: 2107 PKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLPSQLPQH 2166
Query: 721 DFLNDLEPLGWLHTQPNELPQLSPQDVTAHSRILESNKQWDGEKCIILTCSFTPGSCSLT 542
++L ++EPLGW+HTQPNE PQLSPQDVT H++I+ N WDGEK II+TCSFTPGSC+LT
Sbjct: 2167 EYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLT 2226
Query: 541 SYKLTQAGYEWGRLNKDTGSNPHGYLPTHYEKVQMLLSDRFLGFYMVPENGPWNYNFMGV 362
+YKLT +GYEWGR N D G+NP GYLP+HYE+VQMLLSDRFLGF+MVP WNYNFMGV
Sbjct: 2227 AYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGV 2286
Query: 361 KHTVGMKYSVKLGSPKEYYHEEHRPTHFLEFSNMEDADIVEGDREDTFA 215
+H MKY ++L +PKE+YHE HRP+HFL F+ +++ ++ DRED +A
Sbjct: 2287 RHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA 2335
>sp|Q6P2Q9|PRP8_HUMAN Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens
GN=PRPF8 PE=1 SV=2
Length = 2335
Score = 651 bits (1679), Expect = 4e-186
Identities = 294/409 (71%), Positives = 353/409 (86%)
Frame = -3
Query: 1441 ISSYTAFSRLILILRALHVNNEKAKMLLKPDKSVVTEPHHIWPSLTDDQWMKVEVALRDL 1262
ISSYTAFSRLILILRALHVNN++AK++LKPDK+ +TEPHHIWP+LTD++W+KVEV L+DL
Sbjct: 1927 ISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVEVQLKDL 1986
Query: 1261 ILSDYAKKNNVNTSALTQSEIRDIILGAEITPPSQQRQQIAEIEKQAKEASQLNAVTTRT 1082
IL+DY KKNNVN ++LTQSEIRDIILG EI+ PSQQRQQIAEIEKQ KE SQL A TRT
Sbjct: 1987 ILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLTATQTRT 2046
Query: 1081 TNVHGEELIVTTTSPYEQTAFGSKTDWRVRAISATNLYLRVNHIYVNSDDIKETGYTYIM 902
N HG+E+I +TTS YE F SKT+WRVRAISA NL+LR NHIYV+SDDIKETGYTYI+
Sbjct: 2047 VNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYIL 2106
Query: 901 PKNILKKLICVADLRTQIAGYLYGISPPDNPQVKEIRCVVMVPQWGSHQHVNLPSALPEH 722
PKN+LKK IC++DLR QIAGYLYG+SPPDNPQVKEIRC+VMVPQWG+HQ V+LP LP+H
Sbjct: 2107 PKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLPGQLPQH 2166
Query: 721 DFLNDLEPLGWLHTQPNELPQLSPQDVTAHSRILESNKQWDGEKCIILTCSFTPGSCSLT 542
++L ++EPLGW+HTQPNE PQLSPQDVT H++I+ N WDGEK II+TCSFTPGSC+LT
Sbjct: 2167 EYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLT 2226
Query: 541 SYKLTQAGYEWGRLNKDTGSNPHGYLPTHYEKVQMLLSDRFLGFYMVPENGPWNYNFMGV 362
+YKLT +GYEWGR N D G+NP GYLP+HYE+VQMLLSDRFLGF+MVP WNYNFMGV
Sbjct: 2227 AYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGV 2286
Query: 361 KHTVGMKYSVKLGSPKEYYHEEHRPTHFLEFSNMEDADIVEGDREDTFA 215
+H MKY ++L +PKE+YHE HRP+HFL F+ +++ ++ DRED +A
Sbjct: 2287 RHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA 2335
>sp|P34369|PRP8_CAEEL Pre-mRNA-splicing factor 8 homolog OS=Caenorhabditis
elegans GN=prp-8 PE=1 SV=1
Length = 2329
Score = 620 bits (1598), Expect = 9e-177
Identities = 280/410 (68%), Positives = 343/410 (83%), Gaps = 1/410 (0%)
Frame = -3
Query: 1441 ISSYTAFSRLILILRALHVNNEKAKMLLKPDKSVVTEPHHIWPSLTDDQWMKVEVALRDL 1262
ISSYTAFSR++LI+R +H+N +K K++LKPDK+ +TEPHHIWP+L+DD W+KVE+AL+D+
Sbjct: 1920 ISSYTAFSRVVLIMRGMHINPDKTKVILKPDKTTITEPHHIWPTLSDDDWIKVELALKDM 1979
Query: 1261 ILSDYAKKNNVNTSALTQSEIRDIILGAEITPPSQQRQQIAEIEKQAKEASQLNAVTTRT 1082
IL+DY KKNNVN ++LTQSE+RDIILG EI+ PSQQRQQIA+IEKQ KE SQ+ A TTRT
Sbjct: 1980 ILADYGKKNNVNVASLTQSEVRDIILGMEISAPSQQRQQIADIEKQTKEQSQVTATTTRT 2039
Query: 1081 TNVHGEELIVTTTSPYEQTAFGSKTDWRVRAISATNLYLRVNHIYVNSDDIKETGYTYIM 902
N HG+E+I TTS YE +F S+T+WRVRAIS+TNL+LR HIYVNSDD+K+TGYTYI+
Sbjct: 2040 VNKHGDEIITATTSNYETASFASRTEWRVRAISSTNLHLRTQHIYVNSDDVKDTGYTYIL 2099
Query: 901 PKNILKKLICVADLRTQIAGYLYGISPPDNPQVKEIRCVVMVPQWGSHQHVNLPSALPEH 722
PKNILKK I ++DLRTQIAG++YG+SPPDNPQVKEIRC+V+VPQ GSHQ VNLP+ LP+H
Sbjct: 2100 PKNILKKFITISDLRTQIAGFMYGVSPPDNPQVKEIRCIVLVPQTGSHQQVNLPTQLPDH 2159
Query: 721 DFLNDLEPLGWLHTQPNELPQLSPQDVTAHSRILESNKQWDGEKCIILTCSFTPGSCSLT 542
+ L D EPLGW+HTQPNELPQLSPQDVT H+++L N WDGEK +++TCSFTPGS SLT
Sbjct: 2160 ELLRDFEPLGWMHTQPNELPQLSPQDVTTHAKLLTDNISWDGEKTVMITCSFTPGSVSLT 2219
Query: 541 SYKLTQAGYEWGRLNKDTGSNPHGYLPTHYEKVQMLLSDRFLGFYMVPENGPWNYNFMGV 362
+YKLT +GYEWG+ N D G+NP GY+PTHYEKVQMLLSDRFLG++MVP NG WNYNF G
Sbjct: 2220 AYKLTPSGYEWGKANTDKGNNPKGYMPTHYEKVQMLLSDRFLGYFMVPSNGVWNYNFQGQ 2279
Query: 361 KHTVGMKYSVKLGSPKEYYHEEHRPTHFLEFSNMED-ADIVEGDREDTFA 215
+ + MK+ V L +PKEYYHE+HRP HF F +D DRED FA
Sbjct: 2280 RWSPAMKFDVCLSNPKEYYHEDHRPVHFHNFKAFDDPLGTGSADREDAFA 2329
>sp|Q8T295|PRP8_DICDI Pre-mRNA-processing-splicing factor 8 homolog
OS=Dictyostelium discoideum GN=prpf8 PE=3 SV=1
Length = 2327
Score = 560 bits (1442), Expect = 1e-158
Identities = 267/396 (67%), Positives = 320/396 (80%), Gaps = 4/396 (1%)
Frame = -3
Query: 1441 ISSYTAFSRLILILRALHVNNEKAKMLLKPDKSVVTEPHHIWPSLTDDQWMKVEVALRDL 1262
I SYTAF RLILILRALHVN E+ K++LKP+K+V+T+PHHIWP+LT+ +W+ VE +L+DL
Sbjct: 1915 IHSYTAFLRLILILRALHVNLERTKIILKPNKNVITQPHHIWPTLTEQEWLTVEGSLKDL 1974
Query: 1261 ILSDYAKKNNVNTSALTQSEIRDIILGAEITPPSQQRQ-QIAEIEKQAKEASQLNAVTTR 1085
IL+D+ K+NNVN ++LTQSEIRDIILG EI+ PSQQR+ QIAEIEKQ EAS L AVT R
Sbjct: 1975 ILADFGKRNNVNVASLTQSEIRDIILGMEISAPSQQREDQIAEIEKQKTEASHLTAVTVR 2034
Query: 1084 TTNVHGEELIVTTTSPYEQTAFGSKTDWRVRAISATNLYLRVNHIYVNSDDIKET-GYTY 908
+TN+HGEE+I T TSP+EQ F SKTDWRVRAISATNL+LR N IYVNSD+ KET G+TY
Sbjct: 2035 STNIHGEEIITTATSPHEQKVFSSKTDWRVRAISATNLHLRTNQIYVNSDNAKETGGFTY 2094
Query: 907 IMPKNILKKLICVADLRTQIAGYLYGISPPDNPQVKEIRCVVMVPQWGSHQHVNLPSALP 728
+ PKNILKK I +ADLRTQI GY YGISPPDNP VKEIRC+VM PQWG+ HV +P+ LP
Sbjct: 2095 VFPKNILKKFITIADLRTQIMGYCYGISPPDNPSVKEIRCIVMPPQWGTPVHVTVPNQLP 2154
Query: 727 EHDFLNDLEPLGWLHTQPNELPQLSPQDVTAHSRILESNKQWDGEKCIILTCSFTPGSCS 548
EH++L DLEPLGW+HTQP ELPQLSPQDV HS+I+ NK WDGEK +I++ S C+
Sbjct: 2155 EHEYLKDLEPLGWIHTQPTELPQLSPQDVITHSKIMSDNKSWDGEKTVIISVS-VAWPCT 2213
Query: 547 LTSYKLTQAGYEWGRLNKDTGSNPHGYLPTHYEKVQMLLSDRFLGFYMVPENGPWNYNFM 368
LT+Y LT +G+EWG+ NKD+ N GY P YEKVQMLLSDRFLGFYMVP+ G WNYNFM
Sbjct: 2214 LTAYHLTPSGFEWGKNNKDS-LNYQGYQPQFYEKVQMLLSDRFLGFYMVPDRGSWNYNFM 2272
Query: 367 GVKHTVGMKYSVKLGSPKEYYHEEHRPTHFLEFSNM 260
GVKH+ M Y +KL PK +Y E HRP HF ++ M
Sbjct: 2273 GVKHSTNMTYGLKLDYPKNFYDESHRPAHFQNWTQM 2308
>sp|O14187|SPP42_SCHPO Pre-mRNA-splicing factor spp42 OS=Schizosaccharomyces
pombe GN=spp42 PE=1 SV=1
Length = 2363
Score = 492 bits (1266), Expect = 3e-138
Identities = 243/415 (58%), Positives = 312/415 (75%), Gaps = 8/415 (1%)
Frame = -3
Query: 1441 ISSYTAFSRLILILRALHVNNEKAKMLLKPDKSVVTEPHHIWPSLTDDQWMKVEVALRDL 1262
+SSYTAFSRLILILRAL+VN EK K++L+PDKS++T+ +H+WP+L D QW+ VE LRDL
Sbjct: 1951 VSSYTAFSRLILILRALNVNTEKTKLILRPDKSIITKENHVWPNLDDQQWLDVEPKLRDL 2010
Query: 1261 ILSDYAKKNNVNTSALTQSEIRDIILGAEITPPSQQRQQIAEIEKQAKEASQLNAVTTRT 1082
IL+DYAKKNN+N ++LT SE+RDIILG IT PS QRQQIAEIEKQ +E +Q+ AVTT+T
Sbjct: 2011 ILADYAKKNNINVASLTNSEVRDIILGMTITAPSLQRQQIAEIEKQGRENAQVTAVTTKT 2070
Query: 1081 TNVHGEELIVTTTSPYEQTAFGSKTDWRVRAISATNLYLRVNHIYVNSDDIKET-GYTYI 905
TNVHG+E++VTTTS YE F SKT+WR RAIS+ +L LR +IYVNSD+I ET YTYI
Sbjct: 2071 TNVHGDEMVVTTTSAYENEKFSSKTEWRNRAISSISLPLRTKNIYVNSDNISETFPYTYI 2130
Query: 904 MPKNILKKLICVADLRTQIAGYLYGISPPDNPQVKEIRCVVMVPQWGSHQHVNLPSALPE 725
+P+N+L+K + ++DLRTQ+AGY+YG SP DNPQ+KEIRC+ +VPQ GS ++V LPS LP
Sbjct: 2131 LPQNLLRKFVTISDLRTQVAGYMYGKSPSDNPQIKEIRCIALVPQLGSIRNVQLPSKLP- 2189
Query: 724 HD----FLNDLEPLGWLHTQPNELPQLSPQDVTAHSRILESNKQWDGEKCIILTCSFTPG 557
HD L DLEPLGW+HTQ +ELP LS DVT H++IL S+ +WD K + LT S+ PG
Sbjct: 2190 HDLQPSILEDLEPLGWIHTQSSELPYLSSVDVTTHAKILSSHPEWD-TKAVTLTVSYIPG 2248
Query: 556 SCSLTSYKLTQAGYEWGRLNKDTGSNPH-GYLPTHYEKVQMLLSDRFLGFYMVPENGPWN 380
S SL +Y +++ G EWG N D S+ GY P+ EK Q+LLSDR GF++VPE G WN
Sbjct: 2249 SISLAAYTVSKEGIEWGSKNMDINSDEAIGYEPSMAEKCQLLLSDRIQGFFLVPEEGVWN 2308
Query: 379 YNFMGVKHTVGMKYSVKLGSPKEYYHEEHRPTHFLEFSNMEDADIVEGDREDTFA 215
YNF G + M YS+KL P ++ EHRPTH + ++ +E D +E D D FA
Sbjct: 2309 YNFNGASFSPKMTYSLKLDVPLPFFALEHRPTHVISYTELETNDRLEEDMPDAFA 2363
>sp|P33334|PRP8_YEAST Pre-mRNA-splicing factor 8 OS=Saccharomyces cerevisiae
GN=PRP8 PE=1 SV=1
Length = 2413
Score = 363 bits (931), Expect = 2e-099
Identities = 188/420 (44%), Positives = 265/420 (63%), Gaps = 16/420 (3%)
Frame = -3
Query: 1441 ISSYTAFSRLILILRALHVNNEKAKMLLKPDKSVVTEPHHIWPSLTDDQWMKVEVALRDL 1262
ISSYTAFSRL L+LRAL N E AKM+L D ++ + +H+WPS TD+QW+ +E +RDL
Sbjct: 1999 ISSYTAFSRLTLLLRALKTNEESAKMILLSDPTITIKSYHLWPSFTDEQWITIESQMRDL 2058
Query: 1261 ILSDYAKKNNVNTSALTQSEIRDIILGAEITPPSQQRQQIAEIEKQAKE-------ASQL 1103
IL++Y +K NVN SALTQ+EI+DIILG I PS +RQ++AE+E E A
Sbjct: 2059 ILTEYGRKYNVNISALTQTEIKDIILGQNIKAPSVKRQKMAELEAARSEKQNDEEAAGAS 2118
Query: 1102 NAVTTRTTNVHGEELIVTTTSPYEQTAFGSKTDWRVRAISATNLYLRVNHIYVNSDDIKE 923
+ T+T N GEE++V ++ YE F SK +WR AI+ T LYLR+ +IYV++DD E
Sbjct: 2119 TVMKTKTINAQGEEIVVVASADYESQTFSSKNEWRKSAIANTLLYLRLKNIYVSADDFVE 2178
Query: 922 TGYTYIMPKNILKKLICVADLRTQIAGYLYGISPPDNPQVKEIRCVVMVPQWGSHQHVNL 743
Y++PKN+LKK I ++D++ Q+A ++YG+S D+P+VKEI+ VV+VPQ G V +
Sbjct: 2179 EQNVYVLPKNLLKKFIEISDVKIQVAAFIYGMSAKDHPKVKEIKTVVLVPQLGHVGSVQI 2238
Query: 742 PSALPEHDFLND---LEPLGWLHTQPNELPQLSPQDVTAHSRILESNKQWDGEKCIILTC 572
S +P+ L D LE LGW+HTQ EL ++ +V HS++ K+ CI ++
Sbjct: 2239 -SNIPDIGDLPDTEGLELLGWIHTQTEELKFMAASEVATHSKLFADKKR----DCIDISI 2293
Query: 571 SFTPGSCSLTSYKLTQAGYEWGRLNKD-TGSNPHGYLPTHYEKVQMLLSDRFLGFYMVPE 395
TPGS SL++Y LT GY+WG NKD G+ PT Q+LLSDR G +++P
Sbjct: 2294 FSTPGSVSLSAYNLTDEGYQWGEENKDIMNVLSEGFEPTFSTHAQLLLSDRITGNFIIPS 2353
Query: 394 NGPWNYNFMGVKHTVGMKYSVKLGSPKEYYHEEHRPTHFLEFSNMEDADIVEGDREDTFA 215
WNY FMG Y+ K G P E+Y+E HRP HFL+FS + + +E ++ D F+
Sbjct: 2354 GNVWNYTFMGTAFNQEGDYNFKYGIPLEFYNEMHRPVHFLQFSELAGDEELEAEQIDVFS 2413
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,801,685,782
Number of Sequences: 518415
Number of Extensions: 36801685782
Number of Successful Extensions: 258262551
Number of sequences better than 0.0: 0
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