BLASTX 7.6.2
Query= UN08999 /QuerySize=717
(716 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9ST43|PH1_ARATH Pleckstrin homology domain-containing protei... 273 7e-073
sp|Q80TI1|PKHH1_MOUSE Pleckstrin homology domain-containing fami... 67 1e-010
sp|Q9ULM0|PKHH1_HUMAN Pleckstrin homology domain-containing fami... 66 2e-010
sp|Q86IV4|Y4775_DICDI PH domain-containing protein DDB_G0274775 ... 65 3e-010
sp|Q8N264|RHG24_HUMAN Rho GTPase-activating protein 24 OS=Homo s... 61 7e-009
sp|Q559T8|Y0701_DICDI Probable serine/threonine-protein kinase D... 61 7e-009
sp|Q9W5D0|Y34F_DROME Uncharacterized protein CG42248 OS=Drosophi... 60 1e-008
sp|Q00IB7|PKHH1_DANRE Pleckstrin homology domain-containing fami... 60 1e-008
sp|Q5U2Z7|RHG24_RAT Rho GTPase-activating protein 24 OS=Rattus n... 59 4e-008
sp|Q8C115|PKHH2_MOUSE Pleckstrin homology domain-containing fami... 58 6e-008
sp|Q8C4V1|RHG24_MOUSE Rho GTPase-activating protein 24 OS=Mus mu... 57 8e-008
sp|Q8IVE3|PKHH2_HUMAN Pleckstrin homology domain-containing fami... 57 1e-007
sp|Q8BL80|RHG22_MOUSE Rho GTPase-activating protein 22 OS=Mus mu... 55 5e-007
sp|Q7Z5H3|RHG22_HUMAN Rho GTPase-activating protein 22 OS=Homo s... 54 7e-007
sp|O08967|CYH3_MOUSE Cytohesin-3 OS=Mus musculus GN=Cyth3 PE=1 SV=1 53 2e-006
sp|Q9UIA0|CYH4_HUMAN Cytohesin-4 OS=Homo sapiens GN=CYTH4 PE=1 SV=1 53 2e-006
sp|Q80YW0|CYH4_MOUSE Cytohesin-4 OS=Mus musculus GN=Cyth4 PE=2 SV=1 52 3e-006
sp|Q76MY7|CYH2_CERAE Cytohesin-2 OS=Cercopithecus aethiops GN=CY... 52 3e-006
sp|Q54KA7|SECG_DICDI Ankyrin repeat, PH and SEC7 domain containi... 52 4e-006
>sp|Q9ST43|PH1_ARATH Pleckstrin homology domain-containing protein 1
OS=Arabidopsis thaliana GN=PH1 PE=2 SV=2
Length = 145
Score = 273 bits (698), Expect = 7e-073
Identities = 128/144 (88%), Positives = 136/144 (94%)
Frame = +2
Query: 56 MENLWRIATGQDPNRQDYEGIEFWSNPERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKD 235
ME++WRIATGQDP+R+DYEGIEFWSNPERSGWL KQGDYIKTWRRRWFVLKRGKLLWFKD
Sbjct: 1 MESIWRIATGQDPSREDYEGIEFWSNPERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKD 60
Query: 236 QSAALTRGSVPRGVISVGDCLTVKGAGDVVNKAFAFEISSGNITMFFVADNEKEKEEWIN 415
Q+AA RGS PRGVISVGDCLTVKGA DVVNK FAFE+SSG+ TMFF+ADNEKEKEEWIN
Sbjct: 61 QAAAGIRGSTPRGVISVGDCLTVKGAEDVVNKPFAFELSSGSYTMFFIADNEKEKEEWIN 120
Query: 416 SIGRSIVQHSRSVTDSEVLDYDQR 487
SIGRSIVQHSRSVTDSEVLDYD R
Sbjct: 121 SIGRSIVQHSRSVTDSEVLDYDHR 144
>sp|Q80TI1|PKHH1_MOUSE Pleckstrin homology domain-containing family H member 1
OS=Mus musculus GN=Plekhh1 PE=2 SV=2
Length = 1356
Score = 67 bits (162), Expect = 1e-010
Identities = 34/93 (36%), Positives = 56/93 (60%), Gaps = 9/93 (9%)
Frame = +2
Query: 137 ERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSVPRGVISVGD-CLTVKGA 313
E+SG+L K G +KTW+RRWFVL++G++L++K S + + P+G + + C V+
Sbjct: 574 EKSGYLLKMGSRVKTWKRRWFVLRQGQILYYKSPSDVIRK---PQGQVDLNSHCQIVR-- 628
Query: 314 GDVVNKAFAFEISSGNITMFFVADNEKEKEEWI 412
+A F++ SGN T + A++ EEWI
Sbjct: 629 ---EEEAQTFQLISGNKTYYLTAESPSLLEEWI 658
>sp|Q9ULM0|PKHH1_HUMAN Pleckstrin homology domain-containing family H member 1
OS=Homo sapiens GN=PLEKHH1 PE=2 SV=2
Length = 1364
Score = 66 bits (160), Expect = 2e-010
Identities = 33/93 (35%), Positives = 55/93 (59%), Gaps = 9/93 (9%)
Frame = +2
Query: 137 ERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSVPRGVISVGD-CLTVKGA 313
E+SG+L K G +KTW+RRWFVL++G+++++K S + + P+G + + C V+G
Sbjct: 580 EKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRK---PQGQVDLNSRCQIVRGE 636
Query: 314 GDVVNKAFAFEISSGNITMFFVADNEKEKEEWI 412
G + F++ S T + AD+ EEWI
Sbjct: 637 G-----SQTFQLISEKKTYYLTADSPSLLEEWI 664
>sp|Q86IV4|Y4775_DICDI PH domain-containing protein DDB_G0274775
OS=Dictyostelium discoideum GN=DDB_G0274775 PE=4 SV=1
Length = 458
Score = 65 bits (158), Expect = 3e-010
Identities = 36/101 (35%), Positives = 55/101 (54%), Gaps = 8/101 (7%)
Frame = +2
Query: 137 ERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSV-PRGVISVGDCLTVKGA 313
+R GWL KQG I+TWRRRWFVLK KL +FK ++G + G+I + VK
Sbjct: 17 DREGWLTKQGGSIRTWRRRWFVLKGKKLFYFK------SKGDIEATGLIELEQNSFVKEE 70
Query: 314 GDV-VNKAFAFEISSGNITMFFVADNEKEKEEWINSIGRSI 433
D K + F + + + A+ E + ++W+ SI R++
Sbjct: 71 KDKDKKKKYMFTVGTSKRVFYIFAETETDMKQWMESIKRNL 111
>sp|Q8N264|RHG24_HUMAN Rho GTPase-activating protein 24 OS=Homo sapiens
GN=ARHGAP24 PE=1 SV=2
Length = 748
Score = 61 bits (146), Expect = 7e-009
Identities = 34/106 (32%), Positives = 54/106 (50%), Gaps = 5/106 (4%)
Frame = +2
Query: 131 NPERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSV--PRGVISVGDCLTV 304
N + GWL KQG ++KTW RWFVLK +L +FKD+ G++ P +S C
Sbjct: 19 NAIKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEE 78
Query: 305 ---KGAGDVVNKAFAFEISSGNITMFFVADNEKEKEEWINSIGRSI 433
K +VV +++ + + +A + + E+W+ SI R I
Sbjct: 79 NPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVI 124
>sp|Q559T8|Y0701_DICDI Probable serine/threonine-protein kinase DDB_G0272282
OS=Dictyostelium discoideum GN=DDB_G0272282 PE=3 SV=1
Length = 2102
Score = 61 bits (146), Expect = 7e-009
Identities = 36/102 (35%), Positives = 59/102 (57%), Gaps = 11/102 (10%)
Frame = +2
Query: 128 SNPERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSVPRGVISVGDCLTVK 307
+NP++SG+L K+G I++W++R+FVLK G + +FK QS G +P +G +K
Sbjct: 123 NNPDKSGYLIKEGHVIRSWKKRYFVLKDGLIYYFKHQSDQEPTGMIP----VIGS--QIK 176
Query: 308 GAGDVVNKAFAFEISSGNITMF----FVADNEKEKEEWINSI 421
G+ K F+F+I N T F A +E++ +WI +I
Sbjct: 177 RIGETERK-FSFQIIPKNETFFPTFSIQARDEQDCNDWIKAI 217
>sp|Q9W5D0|Y34F_DROME Uncharacterized protein CG42248 OS=Drosophila melanogaster
GN=CG42248 PE=1 SV=4
Length = 1820
Score = 60 bits (145), Expect = 1e-008
Identities = 40/118 (33%), Positives = 59/118 (50%), Gaps = 10/118 (8%)
Frame = +2
Query: 137 ERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSVPRGVISVGDCLTVKGAG 316
E+ G LAK G +KTWR+RWFVLK G L ++K Q + P+G I + + + A
Sbjct: 911 EKMGHLAKLGGKLKTWRKRWFVLKNGSLNYWKSQHDVQRK---PQGQIQLDEVCRINRA- 966
Query: 317 DVVNKAFAFEISSGNITMFFVADNEKEKEEWINSIGRSIVQHSRSVTDSEVLDYDQRP 490
A FEI +G + AD+ ++WI + VQ R+ T + DQ+P
Sbjct: 967 ---EGASTFEIDTGKKVYYLTADSHATMDDWIRVLQN--VQR-RNATKLLLSRDDQKP 1018
>sp|Q00IB7|PKHH1_DANRE Pleckstrin homology domain-containing family H member 1
OS=Danio rerio GN=plekhh1 PE=2 SV=1
Length = 1433
Score = 60 bits (144), Expect = 1e-008
Identities = 35/114 (30%), Positives = 62/114 (54%), Gaps = 11/114 (9%)
Frame = +2
Query: 137 ERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSVPRGVISV-GDCLTVKGA 313
E++G+L K G +K W+RRWF+L+ G++L++K S + + P+G + + C +G
Sbjct: 645 EKTGYLLKMGSQVKAWKRRWFILRNGEILYYKSPSDVIRK---PQGQMELNSSCHIARGE 701
Query: 314 GDVVNKAFAFEISSGNITMFFVADNEKEKEEWINSIGRSI-VQHSRSVT-DSEV 469
G A F++ + T + AD+ E+WI + + VQ S ++ D EV
Sbjct: 702 G-----AQTFQLITEKKTFYLAADSPNILEDWIRVLQNVLKVQASGPISMDKEV 750
>sp|Q5U2Z7|RHG24_RAT Rho GTPase-activating protein 24 OS=Rattus norvegicus
GN=Arhgap24 PE=2 SV=2
Length = 748
Score = 59 bits (140), Expect = 4e-008
Identities = 33/106 (31%), Positives = 53/106 (50%), Gaps = 5/106 (4%)
Frame = +2
Query: 131 NPERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSV--PRGVISVGDC--- 295
N + GWL KQG ++KTW RWFVLK +L +FKD+ G++ P + C
Sbjct: 18 NATKCGWLRKQGGFVKTWHTRWFVLKGDQLHYFKDEDETKPLGTIFLPGNKVIEHPCNEE 77
Query: 296 LTVKGAGDVVNKAFAFEISSGNITMFFVADNEKEKEEWINSIGRSI 433
K +VV +++ + + +A + + E+W+ SI R I
Sbjct: 78 SPGKFLFEVVPGGERDRMTANHESYLLMASTQNDMEDWVKSIRRVI 123
>sp|Q8C115|PKHH2_MOUSE Pleckstrin homology domain-containing family H member 2
OS=Mus musculus GN=Plekhh2 PE=2 SV=2
Length = 1491
Score = 58 bits (138), Expect = 6e-008
Identities = 32/93 (34%), Positives = 52/93 (55%), Gaps = 9/93 (9%)
Frame = +2
Query: 137 ERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSVPRGVISV-GDCLTVKGA 313
E+SG+L K +KTW+RRWFVLK G+LL++K S + + P+G I + C ++G
Sbjct: 704 EKSGYLLKMSVRVKTWKRRWFVLKGGELLYYKSPSDVIRK---PQGHIELSASCSILRG- 759
Query: 314 GDVVNKAFAFEISSGNITMFFVADNEKEKEEWI 412
+ ++++ T + AD+ EEWI
Sbjct: 760 ----DNKQTVQLATEKHTYYLTADSPNILEEWI 788
>sp|Q8C4V1|RHG24_MOUSE Rho GTPase-activating protein 24 OS=Mus musculus
GN=Arhgap24 PE=2 SV=2
Length = 747
Score = 57 bits (137), Expect = 8e-008
Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 5/103 (4%)
Frame = +2
Query: 140 RSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSV-PRGVISVGDCLTVKGAG 316
+ GWL KQG ++KTW RWFVLK +L +FKD+ G++ G + + G
Sbjct: 20 KCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLHGNKVIEHPCNEENPG 79
Query: 317 ----DVVNKAFAFEISSGNITMFFVADNEKEKEEWINSIGRSI 433
DVV +++ + + +A + + E+W+ SI R I
Sbjct: 80 KFLFDVVPGGERDRMTANHESYLLMASTQNDMEDWVKSIRRVI 122
>sp|Q8IVE3|PKHH2_HUMAN Pleckstrin homology domain-containing family H member 2
OS=Homo sapiens GN=PLEKHH2 PE=2 SV=2
Length = 1493
Score = 57 bits (136), Expect = 1e-007
Identities = 31/93 (33%), Positives = 52/93 (55%), Gaps = 9/93 (9%)
Frame = +2
Query: 137 ERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSVPRGVISV-GDCLTVKGA 313
E+SG+L K +K+W+RRWFVLK G+LL++K S + + P+G I + C ++G
Sbjct: 705 EKSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRK---PQGHIELSASCSILRG- 760
Query: 314 GDVVNKAFAFEISSGNITMFFVADNEKEKEEWI 412
+ ++++ T + AD+ EEWI
Sbjct: 761 ----DNKQTVQLTTEKHTYYLTADSPNILEEWI 789
>sp|Q8BL80|RHG22_MOUSE Rho GTPase-activating protein 22 OS=Mus musculus
GN=Arhgap22 PE=1 SV=2
Length = 702
Score = 55 bits (130), Expect = 5e-007
Identities = 32/110 (29%), Positives = 56/110 (50%), Gaps = 17/110 (15%)
Frame = +2
Query: 140 RSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSVPRGVISVGDCLTVKGAGD 319
++GWL KQ +K W++RWFVL+ +L ++KD+ S P+G IS+ + D
Sbjct: 46 KAGWLRKQRSIMKNWQQRWFVLRGDQLFYYKDKDE-----SKPQGFISLQGTQVTELLPD 100
Query: 320 VVNKA-FAFEISSGNIT-----------MFFVADNEKEKEEWINSIGRSI 433
+ FEI+ G T + +A ++++ E+W+ +I R I
Sbjct: 101 PEDPGKHLFEITPGGATEREKVPANPEALLLMASSQRDMEDWVQAIRRVI 150
>sp|Q7Z5H3|RHG22_HUMAN Rho GTPase-activating protein 22 OS=Homo sapiens
GN=ARHGAP22 PE=1 SV=1
Length = 698
Score = 54 bits (129), Expect = 7e-007
Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 17/110 (15%)
Frame = +2
Query: 140 RSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSVPRGVISV-GDCLTVKGAG 316
++GWL KQ +K W++RWFVL+ +L ++KD+ P+G IS+ G +T G
Sbjct: 40 KAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEI-----KPQGFISLQGTQVTELPPG 94
Query: 317 DVVNKAFAFEISSGNI-----------TMFFVADNEKEKEEWINSIGRSI 433
FEIS G + +A ++++ E+W+ +I R I
Sbjct: 95 PEDPGKHLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVI 144
>sp|O08967|CYH3_MOUSE Cytohesin-3 OS=Mus musculus GN=Cyth3 PE=1 SV=1
Length = 399
Score = 53 bits (125), Expect = 2e-006
Identities = 27/87 (31%), Positives = 45/87 (51%), Gaps = 3/87 (3%)
Frame = +2
Query: 35 GERERERMENLWRIATGQDPNRQDYEGIEF---WSNPERSGWLAKQGDYIKTWRRRWFVL 205
G+ E + NL+ + + +G + + NP+R GWL K G +KTW+RRWF+L
Sbjct: 229 GDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFIL 288
Query: 206 KRGKLLWFKDQSAALTRGSVPRGVISV 286
L +F+ + RG +P +S+
Sbjct: 289 TDNCLYYFEYTTDKEPRGIIPLENLSI 315
>sp|Q9UIA0|CYH4_HUMAN Cytohesin-4 OS=Homo sapiens GN=CYTH4 PE=1 SV=1
Length = 394
Score = 53 bits (125), Expect = 2e-006
Identities = 29/73 (39%), Positives = 41/73 (56%), Gaps = 7/73 (9%)
Frame = +2
Query: 131 NPERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSVPRGVISVGDCLTVKG 310
NP+R GWL K G +KTW+RRWF+L L +F+ T PRG+I + + L+V+
Sbjct: 259 NPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFE-----FTTDKEPRGIIPL-ENLSVQK 312
Query: 311 AGDVVNKAFAFEI 349
D K F E+
Sbjct: 313 VDD-PKKPFCLEL 324
>sp|Q80YW0|CYH4_MOUSE Cytohesin-4 OS=Mus musculus GN=Cyth4 PE=2 SV=1
Length = 393
Score = 52 bits (124), Expect = 3e-006
Identities = 23/52 (44%), Positives = 32/52 (61%)
Frame = +2
Query: 131 NPERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSVPRGVISV 286
NP+R GWL K G +KTW+RRWF+L L +F+ + RG +P +SV
Sbjct: 259 NPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSV 310
>sp|Q76MY7|CYH2_CERAE Cytohesin-2 OS=Cercopithecus aethiops GN=CYTH2 PE=2 SV=1
Length = 399
Score = 52 bits (123), Expect = 3e-006
Identities = 22/52 (42%), Positives = 32/52 (61%)
Frame = +2
Query: 131 NPERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFKDQSAALTRGSVPRGVISV 286
NP+R GWL K G +KTW+RRWF+L L +F+ + RG +P +S+
Sbjct: 259 NPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSI 310
>sp|Q54KA7|SECG_DICDI Ankyrin repeat, PH and SEC7 domain containing protein secG
OS=Dictyostelium discoideum GN=secG PE=2 SV=1
Length = 986
Score = 52 bits (122), Expect = 4e-006
Identities = 27/72 (37%), Positives = 42/72 (58%), Gaps = 3/72 (4%)
Frame = +2
Query: 56 MENLW-RIATGQDPNRQDYEGIEFWSNPERSGWLAKQGDYIKTWRRRWFVLKRGKLLWFK 232
MENL+ +I T + + + +G + + E+ GWL KQG IKTW++RWF+L LL++K
Sbjct: 760 MENLYDKIVTNE--IKMERDGNQANQHVEKKGWLTKQGGRIKTWKKRWFILTANCLLYYK 817
Query: 233 DQSAALTRGSVP 268
G +P
Sbjct: 818 TPQDHEPCGIIP 829
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,801,685,782
Number of Sequences: 518415
Number of Extensions: 36801685782
Number of Successful Extensions: 258262551
Number of sequences better than 0.0: 0
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