BLASTX 7.6.2
Query= UN09466 /QuerySize=1806
(1805 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O65726|ERG12_BRANA Squalene monooxygenase 1,2 OS=Brassica nap... 943 6e-274
sp|O65404|ERG11_ARATH Squalene monooxygenase 1,1 OS=Arabidopsis ... 827 6e-239
sp|O65402|ERG12_ARATH Squalene monooxygenase 1,2 OS=Arabidopsis ... 802 2e-231
sp|O65727|ERG11_BRANA Squalene monooxygenase 1,1 OS=Brassica nap... 757 6e-218
sp|O65403|ERG13_ARATH Squalene monooxygenase 2 OS=Arabidopsis th... 647 9e-185
sp|O48651|ERG1_PANGI Squalene monooxygenase OS=Panax ginseng PE=... 458 8e-128
sp|Q14534|ERG1_HUMAN Squalene monooxygenase OS=Homo sapiens GN=S... 278 1e-073
sp|P52019|ERG1_MOUSE Squalene monooxygenase OS=Mus musculus GN=S... 257 3e-067
sp|Q9C1W3|ERG1_SCHPO Probable squalene monooxygenase OS=Schizosa... 255 1e-066
sp|P52020|ERG1_RAT Squalene monooxygenase OS=Rattus norvegicus G... 247 2e-064
sp|O13306|ERG1_CANGA Squalene monooxygenase OS=Candida glabrata ... 75 1e-012
sp|P32476|ERG1_YEAST Squalene monooxygenase OS=Saccharomyces cer... 74 2e-012
sp|Q75F69|ERG1_ASHGO Squalene monooxygenase OS=Ashbya gossypii G... 72 2e-011
sp|Q92206|ERG1_CANAL Squalene monooxygenase OS=Candida albicans ... 64 2e-009
>sp|O65726|ERG12_BRANA Squalene monooxygenase 1,2 OS=Brassica napus GN=SQP1,2
PE=2 SV=1
Length = 518
Score = 943 bits (2437), Expect = 6e-274
Identities = 478/518 (92%), Positives = 495/518 (95%), Gaps = 1/518 (0%)
Frame = -1
Query: 1775 MNMAFVEVCLWMLLAFVISWTIFHVTN-KMNKATKCANVAAKERRDGGPDVIIVGAGVGG 1599
M+MAFVEVCL MLL FV+SWTIFHV N K KATK A++A +ER++GGPDVIIVGAGVGG
Sbjct: 1 MDMAFVEVCLRMLLVFVLSWTIFHVNNRKKKKATKLADLATEERKEGGPDVIIVGAGVGG 60
Query: 1598 SALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQDCLEGIDAQKSTGI 1419
SALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRL+LSKLGLQDCLE IDAQKSTGI
Sbjct: 61 SALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLMLSKLGLQDCLEEIDAQKSTGI 120
Query: 1418 ALFKDGKETVASYPVDTNFPYEPSGRFFQNGRFVQRLRQKASSLPNVRLEEGTVRSLIEE 1239
LFKDGKETVA +PVDTNFPYEPSGRFF NGRFVQRLRQKASSLPNVRLEEGTVRSLIEE
Sbjct: 121 RLFKDGKETVACFPVDTNFPYEPSGRFFHNGRFVQRLRQKASSLPNVRLEEGTVRSLIEE 180
Query: 1238 KGVVKGVTYKNSSGEETTAFAPLTVVCDGCHSNLRRSLNDNNAEVTAYEIGYISRNCRLE 1059
KGVVKGVTYKNSSGEETT+FAPLTVVCDGCHSNLRRSLNDNNAEVTAYEIGYISRNCRLE
Sbjct: 181 KGVVKGVTYKNSSGEETTSFAPLTVVCDGCHSNLRRSLNDNNAEVTAYEIGYISRNCRLE 240
Query: 1058 QPDKLHLIMAKPSFAMLYQVSSTDVRCNFELLSNNLPSVSNGEMASFVKNSIAPQVPLKF 879
QPDKLHLIMAKPSFAMLYQVSSTDVRCNFELLS NLPSVSNGEM SFV+NSIAPQVPLK
Sbjct: 241 QPDKLHLIMAKPSFAMLYQVSSTDVRCNFELLSKNLPSVSNGEMTSFVRNSIAPQVPLKL 300
Query: 878 RKTFLKGLDEGSHIKITQAKRMPATLSRKKGVIVLGDAFNMRHPVIASGMMVLLSDILIL 699
RKTFLKGLDEGSHIKITQAKR+PATLSRKKGVIVLGDAFNMRHPVIASGMMVLLSDILIL
Sbjct: 301 RKTFLKGLDEGSHIKITQAKRIPATLSRKKGVIVLGDAFNMRHPVIASGMMVLLSDILIL 360
Query: 698 SRLLKPLDSLGDENKVSEVMKSFYVLRKPMSATVNTLGNSFWQVLIASTDEAKEAMRQGC 519
SRLLKPL +LGDENKVSEVMKSFY LRKPMSATVNTLGNSFWQVLIASTDEAKEAMRQGC
Sbjct: 361 SRLLKPLGNLGDENKVSEVMKSFYALRKPMSATVNTLGNSFWQVLIASTDEAKEAMRQGC 420
Query: 518 FDYLSSGGFRTSGLMAVFGGMNPRPLSLIYHLSVITLSSIGQLLSPFPTPLRVWHSLRLF 339
FDYLSSGGFRTSGLMA+ GGMNPRPLSL YHL VI+LSSIGQLLSPFPTPLRVWHSLRL
Sbjct: 421 FDYLSSGGFRTSGLMALIGGMNPRPLSLFYHLFVISLSSIGQLLSPFPTPLRVWHSLRLL 480
Query: 338 GLSLELLVPHLKAEGIGQMLSPTNAAAYRKSYMATTVV 225
LSL++LVPHLKAEGIGQMLSPTNAAAYRKSYMA TVV
Sbjct: 481 DLSLKMLVPHLKAEGIGQMLSPTNAAAYRKSYMAATVV 518
>sp|O65404|ERG11_ARATH Squalene monooxygenase 1,1 OS=Arabidopsis thaliana
GN=SQP1,1 PE=2 SV=2
Length = 516
Score = 827 bits (2135), Expect = 6e-239
Identities = 401/516 (77%), Positives = 464/516 (89%), Gaps = 1/516 (0%)
Frame = -1
Query: 1769 MAFVEVCLWMLLAFVISWTIFHVTNKMNKATKCANVAAKERRDGGPDVIIVGAGVGGSAL 1590
MAF VCLW LLAF+++WT+F+VTN+ KAT+ A+ +ER DG DVIIVGAGVGGSAL
Sbjct: 1 MAFTNVCLWTLLAFMLTWTVFYVTNRGKKATQLADAVVEEREDGATDVIIVGAGVGGSAL 60
Query: 1589 AYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQDCLEGIDAQKSTGIALF 1410
AYALAKDGRRVHVIERD+REP R+MGEFMQPGGRL+LSKLGL+DCLEGIDAQK+TG+ ++
Sbjct: 61 AYALAKDGRRVHVIERDLREPERIMGEFMQPGGRLMLSKLGLEDCLEGIDAQKATGMTVY 120
Query: 1409 KDGKETVASYPVD-TNFPYEPSGRFFQNGRFVQRLRQKASSLPNVRLEEGTVRSLIEEKG 1233
KDGKE VAS+PVD NFP++PS R F NGRFVQRLRQKASSLPNVRLEEGTV+SLIEEKG
Sbjct: 121 KDGKEAVASFPVDNNNFPFDPSARSFHNGRFVQRLRQKASSLPNVRLEEGTVKSLIEEKG 180
Query: 1232 VVKGVTYKNSSGEETTAFAPLTVVCDGCHSNLRRSLNDNNAEVTAYEIGYISRNCRLEQP 1053
V+KGVTYKNS+GEETTA APLTVVCDGC+SNLRRSLNDNNAEV +Y++G+IS+NC+LE+P
Sbjct: 181 VIKGVTYKNSAGEETTALAPLTVVCDGCYSNLRRSLNDNNAEVLSYQVGFISKNCQLEEP 240
Query: 1052 DKLHLIMAKPSFAMLYQVSSTDVRCNFELLSNNLPSVSNGEMASFVKNSIAPQVPLKFRK 873
+KL LIM+KPSF MLYQ+SSTDVRC FE+L NN+PS+SNGEMA+FVKN+IAPQVPLK RK
Sbjct: 241 EKLKLIMSKPSFTMLYQISSTDVRCVFEVLPNNIPSISNGEMATFVKNTIAPQVPLKLRK 300
Query: 872 TFLKGLDEGSHIKITQAKRMPATLSRKKGVIVLGDAFNMRHPVIASGMMVLLSDILILSR 693
FLKG+DEG HIK K+M ATLS KKGVI+LGDAFNMRHP IASGMMVLLSDILIL R
Sbjct: 301 IFLKGIDEGEHIKAMPTKKMTATLSEKKGVILLGDAFNMRHPAIASGMMVLLSDILILRR 360
Query: 692 LLKPLDSLGDENKVSEVMKSFYVLRKPMSATVNTLGNSFWQVLIASTDEAKEAMRQGCFD 513
LL+PL +LG+ K+S+V+KSFY +RKPMSATVNTLGN+F QVL+ASTDEAKEAMRQGC+D
Sbjct: 361 LLQPLSNLGNAQKISQVIKSFYDIRKPMSATVNTLGNAFSQVLVASTDEAKEAMRQGCYD 420
Query: 512 YLSSGGFRTSGLMAVFGGMNPRPLSLIYHLSVITLSSIGQLLSPFPTPLRVWHSLRLFGL 333
YLSSGGFRTSG+MA+ GGMNPRP+SLIYHL ITLSSIG LLSPFP+PLR+WHSLRLFGL
Sbjct: 421 YLSSGGFRTSGMMALLGGMNPRPISLIYHLCAITLSSIGHLLSPFPSPLRIWHSLRLFGL 480
Query: 332 SLELLVPHLKAEGIGQMLSPTNAAAYRKSYMATTVV 225
++++LVPHLKAEG+ QML P NAAAY KSYMA T +
Sbjct: 481 AMKMLVPHLKAEGVSQMLFPVNAAAYSKSYMAATAL 516
>sp|O65402|ERG12_ARATH Squalene monooxygenase 1,2 OS=Arabidopsis thaliana
GN=SQP1,2 PE=2 SV=1
Length = 517
Score = 802 bits (2070), Expect = 2e-231
Identities = 392/517 (75%), Positives = 456/517 (88%), Gaps = 2/517 (0%)
Frame = -1
Query: 1769 MAFVEVCLWMLLAFVISWTIFHVTNKMNKATKCANVAAKERRDGGPDVIIVGAGVGGSAL 1590
MAF VCLW L+AFV++WT+F++TN KAT A+ A++++DG DVIIVGAGVGGSAL
Sbjct: 1 MAFTHVCLWTLVAFVLTWTVFYLTNMKKKATDLADTVAEDQKDGAADVIIVGAGVGGSAL 60
Query: 1589 AYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQDCLEGIDAQKSTGIALF 1410
AYALAKDGRRVHVIERDMREP RMMGEFMQPGGRL+LSKLGLQDCLE IDAQK+TG+A++
Sbjct: 61 AYALAKDGRRVHVIERDMREPERMMGEFMQPGGRLMLSKLGLQDCLEDIDAQKATGLAVY 120
Query: 1409 KDGKETVASYPVD-TNFPYEPSGRFFQNGRFVQRLRQKASSLPNVRLEEGTVRSLIEEKG 1233
KDGKE A +PVD NF YEPS R F NGRFVQ+LR+KA SL NVRLEEGTV+SL+EEKG
Sbjct: 121 KDGKEADAPFPVDNNNFSYEPSARSFHNGRFVQQLRRKAFSLSNVRLEEGTVKSLLEEKG 180
Query: 1232 VVKGVTYKNSSGEETTAFAPLTVVCDGCHSNLRRSLN-DNNAEVTAYEIGYISRNCRLEQ 1056
VVKGVTYKN GEETTA APLTVVCDGC+SNLRRSLN DNNAE+ +Y +GYIS+NCRLE+
Sbjct: 181 VVKGVTYKNKEGEETTALAPLTVVCDGCYSNLRRSLNDDNNAEIMSYIVGYISKNCRLEE 240
Query: 1055 PDKLHLIMAKPSFAMLYQVSSTDVRCNFELLSNNLPSVSNGEMASFVKNSIAPQVPLKFR 876
P+KLHLI++KPSF M+YQ+SSTDVRC FE+L N PS++NGEM++F+KN+I PQVP K R
Sbjct: 241 PEKLHLILSKPSFTMVYQISSTDVRCGFEVLPENFPSIANGEMSTFMKNTIVPQVPPKLR 300
Query: 875 KTFLKGLDEGSHIKITQAKRMPATLSRKKGVIVLGDAFNMRHPVIASGMMVLLSDILILS 696
K FLKG+DEG+HIK+ AKRM +TLS+KKGVIVLGDAFNMRHPV+ASGMMVLLSDILIL
Sbjct: 301 KIFLKGIDEGAHIKVVPAKRMTSTLSKKKGVIVLGDAFNMRHPVVASGMMVLLSDILILR 360
Query: 695 RLLKPLDSLGDENKVSEVMKSFYVLRKPMSATVNTLGNSFWQVLIASTDEAKEAMRQGCF 516
RLL+PL +LGD NKVSEV+ SFY +RKPMSATVNTLGN+F QVLI STDEAKEAMRQG +
Sbjct: 361 RLLQPLSNLGDANKVSEVINSFYDIRKPMSATVNTLGNAFSQVLIGSTDEAKEAMRQGVY 420
Query: 515 DYLSSGGFRTSGLMAVFGGMNPRPLSLIYHLSVITLSSIGQLLSPFPTPLRVWHSLRLFG 336
DYL SGGFRTSG+MA+ GGMNPRPLSL+YHL ITLSSIGQLLSPFP+PLR+WHSL+LFG
Sbjct: 421 DYLCSGGFRTSGMMALLGGMNPRPLSLVYHLCAITLSSIGQLLSPFPSPLRIWHSLKLFG 480
Query: 335 LSLELLVPHLKAEGIGQMLSPTNAAAYRKSYMATTVV 225
L++++LVP+LKAEG+ QML P NAAAY KSYMA T +
Sbjct: 481 LAMKMLVPNLKAEGVSQMLFPANAAAYHKSYMAATTL 517
>sp|O65727|ERG11_BRANA Squalene monooxygenase 1,1 OS=Brassica napus GN=SQP1,1
PE=2 SV=1
Length = 506
Score = 757 bits (1954), Expect = 6e-218
Identities = 369/480 (76%), Positives = 426/480 (88%)
Frame = -1
Query: 1775 MNMAFVEVCLWMLLAFVISWTIFHVTNKMNKATKCANVAAKERRDGGPDVIIVGAGVGGS 1596
M++AF VCLW LLAFV++WT+F+V N+ K K + A + RRDG DVIIVGAGVGGS
Sbjct: 1 MDLAFPHVCLWTLLAFVLTWTVFYVNNRRKKVAKLPDAATEVRRDGDADVIIVGAGVGGS 60
Query: 1595 ALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQDCLEGIDAQKSTGIA 1416
ALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGL+DCLEGID Q +TG+A
Sbjct: 61 ALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLEDCLEGIDEQIATGLA 120
Query: 1415 LFKDGKETVASYPVDTNFPYEPSGRFFQNGRFVQRLRQKASSLPNVRLEEGTVRSLIEEK 1236
++KDG++ + S+P D +FPYEP+GR F NGRFVQRLRQKASSLP V+LEEGTV+SLIEEK
Sbjct: 121 VYKDGQKALVSFPEDNDFPYEPTGRAFYNGRFVQRLRQKASSLPTVQLEEGTVKSLIEEK 180
Query: 1235 GVVKGVTYKNSSGEETTAFAPLTVVCDGCHSNLRRSLNDNNAEVTAYEIGYISRNCRLEQ 1056
GV+KGVTYKNS+GEETTAFAPLTVVCDGC+SNLRRS+NDNNAEV +Y++GY+S+NC+LE
Sbjct: 181 GVIKGVTYKNSAGEETTAFAPLTVVCDGCYSNLRRSVNDNNAEVISYQVGYVSKNCQLED 240
Query: 1055 PDKLHLIMAKPSFAMLYQVSSTDVRCNFELLSNNLPSVSNGEMASFVKNSIAPQVPLKFR 876
P+KL LIM+KPSF MLYQ+SSTDVRC E+ N+PS+SNGEMA ++KN++APQVP + R
Sbjct: 241 PEKLKLIMSKPSFTMLYQISSTDVRCVMEIFPGNIPSISNGEMAVYLKNTMAPQVPPELR 300
Query: 875 KTFLKGLDEGSHIKITQAKRMPATLSRKKGVIVLGDAFNMRHPVIASGMMVLLSDILILS 696
K FLKG+DEG+ IK KRM ATLS K+GVIVLGDAFNMRHP IASGMMV+LSDILIL
Sbjct: 301 KIFLKGIDEGAQIKAMPTKRMEATLSEKQGVIVLGDAFNMRHPAIASGMMVVLSDILILR 360
Query: 695 RLLKPLDSLGDENKVSEVMKSFYVLRKPMSATVNTLGNSFWQVLIASTDEAKEAMRQGCF 516
RLL+PL +L D NKVSEV+KSFYV+RKPMSATVNTLGN+F QVLIASTDEAKEAMRQGCF
Sbjct: 361 RLLQPLRNLSDANKVSEVIKSFYVIRKPMSATVNTLGNAFSQVLIASTDEAKEAMRQGCF 420
Query: 515 DYLSSGGFRTSGLMAVFGGMNPRPLSLIYHLSVITLSSIGQLLSPFPTPLRVWHSLRLFG 336
DYLSSGGFRTSG+MA+ GGMNPRPLSLI+HL ITLSSIGQLLSPFP+PL +WHSLRLFG
Sbjct: 421 DYLSSGGFRTSGMMALLGGMNPRPLSLIFHLCGITLSSIGQLLSPFPSPLGIWHSLRLFG 480
>sp|O65403|ERG13_ARATH Squalene monooxygenase 2 OS=Arabidopsis thaliana GN=SQP2
PE=2 SV=1
Length = 516
Score = 647 bits (1668), Expect = 9e-185
Identities = 318/511 (62%), Positives = 402/511 (78%), Gaps = 3/511 (0%)
Frame = -1
Query: 1748 LWMLLAFVISWTIFHVTNKMNKATKCANVAAKERRDGGPDVIIVGAGVGGSALAYALAKD 1569
LW LLAFV++W +FH+ AT A+ RRDG DVIIVGAGV G++LAYALAKD
Sbjct: 6 LWTLLAFVLTWMVFHLIKMKKAATGDLEAEAEARRDGATDVIIVGAGVAGASLAYALAKD 65
Query: 1568 GRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQDCLEGIDAQKSTGIALFKDGKETV 1389
GRRVHVIERD++EP R MGE MQ GGR +L++LGL+DCLE IDAQ++ +A++KDGK
Sbjct: 66 GRRVHVIERDLKEPQRFMGELMQAGGRFMLAQLGLEDCLEDIDAQEAKSLAIYKDGKHAT 125
Query: 1388 ASYPVDTNFPYEPSGRFFQNGRFVQRLRQKASSLPNVRLEEGTVRSLIEEKGVVKGVTYK 1209
+P D +FP+EP GR +NGR VQRLRQKA+SL NV+LEEGTV+SLIEE+GVVKGVTYK
Sbjct: 126 LPFPDDKSFPHEPVGRLLRNGRLVQRLRQKAASLSNVQLEEGTVKSLIEEEGVVKGVTYK 185
Query: 1208 NSSGEETTAFAPLTVVCDGCHSNLRRSLNDNNAEVTAYEIGYISRNCRLEQPDKLHLIMA 1029
NS+GEE TAFAPLTVVCDGC+SNLRRSL DN EV +Y +GY+++N RLE P LHLI +
Sbjct: 186 NSAGEEITAFAPLTVVCDGCYSNLRRSLVDNTEEVLSYMVGYVTKNSRLEDPHSLHLIFS 245
Query: 1028 KPSFAMLYQVSSTDVRCNFELLSNNLPSVSNGEMASFVKNSIAPQVPL--KFRKTFLKGL 855
KP ++YQ++S +VRC E+ ++++PS+SNGEM++F+K S+APQ+P R+ FLKG+
Sbjct: 246 KPLVCVIYQITSDEVRCVAEVPADSIPSISNGEMSTFLKKSMAPQIPETGNLREIFLKGI 305
Query: 854 DEG-SHIKITQAKRMPATLSRKKGVIVLGDAFNMRHPVIASGMMVLLSDILILSRLLKPL 678
+EG IK T K M + L K+GVIVLGDAFNMRHP+IASGMMV LSDI IL LLKPL
Sbjct: 306 EEGLPEIKSTATKSMSSRLCDKRGVIVLGDAFNMRHPIIASGMMVALSDICILRNLLKPL 365
Query: 677 DSLGDENKVSEVMKSFYVLRKPMSATVNTLGNSFWQVLIASTDEAKEAMRQGCFDYLSSG 498
+L + KVS+++KSFY++RKPMSATVNTL + F QVL+A+TDEA+E MRQGCF+YL+ G
Sbjct: 366 PNLSNTKKVSDLVKSFYIIRKPMSATVNTLASIFSQVLVATTDEAREGMRQGCFNYLARG 425
Query: 497 GFRTSGLMAVFGGMNPRPLSLIYHLSVITLSSIGQLLSPFPTPLRVWHSLRLFGLSLELL 318
F+T GLM + GGMNP PL+L+ HL ITL+S+G LLSPFP+P R WHSLR+ +L++L
Sbjct: 426 DFKTRGLMTILGGMNPHPLTLVLHLVAITLTSMGHLLSPFPSPRRFWHSLRILAWALQML 485
Query: 317 VPHLKAEGIGQMLSPTNAAAYRKSYMATTVV 225
HL EG +ML PTNAAAYR++Y+ATT V
Sbjct: 486 GAHLVDEGFKEMLIPTNAAAYRRNYIATTTV 516
>sp|O48651|ERG1_PANGI Squalene monooxygenase OS=Panax ginseng PE=2 SV=1
Length = 539
Score = 458 bits (1177), Expect = 8e-128
Identities = 229/465 (49%), Positives = 321/465 (69%), Gaps = 2/465 (0%)
Frame = -1
Query: 1640 GGPDVIIVGAGVGGSALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQ 1461
G DVIIVGAGV GSALAY LA DGRRVHVIERD+ E R++GE +QPGG L L +LGL+
Sbjct: 73 GSTDVIIVGAGVAGSALAYTLANDGRRVHVIERDLTEQDRIVGELLQPGGYLKLIELGLE 132
Query: 1460 DCLEGIDAQKSTGIALFKDGKETVASYPVDTNFPYEPSGRFFQNGRFVQRLRQKASSLPN 1281
DC+ IDAQ+ G AL+ DGK T SYP++ F + +GR F NGRFVQR+R+KA+SLPN
Sbjct: 133 DCVNEIDAQRVFGYALYMDGKNTRLSYPLE-KFHSDVAGRSFHNGRFVQRMREKAASLPN 191
Query: 1280 VRLEEGTVRSLIEEKGVVKGVTYKNSSGEETTAFAPLTVVCDGCHSNLRRSLNDNNAEVT 1101
VR+E+GTV SL+E+KG VKGV YK G+E +AFAPLT+VCDGC SNLRRSL + EV
Sbjct: 192 VRMEQGTVTSLVEKKGSVKGVQYKTKDGQELSAFAPLTIVCDGCFSNLRRSLCNPKVEVP 251
Query: 1100 AYEIGYISRNCRLEQPDKLHLIMAKPSFAMLYQVSSTDVRCNFELLSNNLPSVSNGEMAS 921
+ +G I N L + H+I+A PS + Y++SST++RC ++ +P +SNGE+A+
Sbjct: 252 SCFVGLILENIDLPHINHGHVILADPSPILFYKISSTEIRCLVDVPGQKVPCISNGELAN 311
Query: 920 FVKNSIAPQVPLKFRKTFLKGLDEGSHIKITQAKRMPATLSRKKGVIVLGDAFNMRHPVI 741
++K +APQVP + +F+ +D+G +I+ + MPA G ++LGDAFNMRHP+
Sbjct: 312 YLKTVVAPQVPKQLYNSFIAAVDKG-NIRTMPNRSMPADPHPTPGALLLGDAFNMRHPLT 370
Query: 740 ASGMMVLLSDILILSRLLKPLDSLGDENKVSEVMKSFYVLRKPMSATVNTLGNSFWQVLI 561
GM V LSDI+++ LL+PL L D + + + ++SFY LRKP+++T+NTL + ++V
Sbjct: 371 GGGMTVALSDIVLIRDLLRPLRDLHDSSTLCKYLESFYTLRKPVASTINTLAGALYKVFC 430
Query: 560 ASTDEAKEAMRQGCFDYLSSGGFRTSGLMAVFGGMNPRPLSLIYHLSVITLSSIGQLLSP 381
AS D+A++ MR CFDYLS GG + G +A+ G+NPRP+SL H + + +G+LL P
Sbjct: 431 ASPDKARQEMRNACFDYLSLGGICSQGPIALLSGLNPRPISLFLHFFAVAIYGVGRLLIP 490
Query: 380 FPTPLRVWHSLRLFGLSLELLVPHLKAEGIGQMLSPTNAAAYRKS 246
FP+P R+W RL + ++ P +K+EG+ QM P AY ++
Sbjct: 491 FPSPKRMWLGARLILGASGIIFPIIKSEGLRQMFFPAIVPAYYRA 535
>sp|Q14534|ERG1_HUMAN Squalene monooxygenase OS=Homo sapiens GN=SQLE PE=2 SV=3
Length = 574
Score = 278 bits (710), Expect = 1e-073
Identities = 161/416 (38%), Positives = 245/416 (58%), Gaps = 12/416 (2%)
Frame = -1
Query: 1634 PDVIIVGAGVGGSALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQDC 1455
P+VIIVGAGV GSALA L++DGR+V VIERD++EP R++GEF+QPGG +L LGL D
Sbjct: 124 PEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDT 183
Query: 1454 LEGIDAQKSTGIALF--KDGKETVASYPVDTNFPYEPSGRFFQNGRFVQRLRQKASSLPN 1281
+EG+DAQ G + + E YP+ N + SGR F +GRF+ LR+ A + PN
Sbjct: 184 VEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQ-SGRAFHHGRFIMSLRKAAMAEPN 242
Query: 1280 VRLEEGTVRSLIEEKGVVKGVTYKN-SSGEETTAFAPLTVVCDGCHSNLRRSLNDNNAEV 1104
+ EG V L+EE VV GV YK+ +G+ APLTVV DG S R+SL N V
Sbjct: 243 AKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSV 302
Query: 1103 TAYEIGYISRNCRLEQPDKLHLIMAKPSFAMLYQVSSTDVRCNFELLSNNLPSVSNGEMA 924
+++ +G++ +N + + LI+A PS ++YQ+SS++ R + + +P +
Sbjct: 303 SSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVD-IRGEMPR----NLR 357
Query: 923 SFVKNSIAPQVPLKFRKTFLKGLDEGSHIKITQAKRMPATLSRKKGVIVLGDAFNMRHPV 744
++ I PQ+P ++ FL+ D SH++ A +P + +K+GV++LGDA+NMRHP+
Sbjct: 358 EYMVEKIYPQIPDHLKEPFLEATD-NSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPL 416
Query: 743 IASGMMVLLSDILILSRLLKPLDSLGDENKVSEVMKSFYVLRKPM-SATVNTLGNSFWQV 567
GM V DI + +LLK + L D+ + E KSFY RK S VN L + ++
Sbjct: 417 TGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYE- 475
Query: 566 LIASTDEAKEAMRQGCFDYLSSGGFRTSGLMAVFGGMNPRPLSLIYHLSVITLSSI 399
L ++TD++ +R+ CF Y GG +G + + ++P PL LI H + + ++
Sbjct: 476 LFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAV 531
>sp|P52019|ERG1_MOUSE Squalene monooxygenase OS=Mus musculus GN=Sqle PE=2 SV=1
Length = 572
Score = 257 bits (654), Expect = 3e-067
Identities = 151/414 (36%), Positives = 242/414 (58%), Gaps = 14/414 (3%)
Frame = -1
Query: 1634 PDVIIVGAGVGGSALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQDC 1455
P+VIIVG+GV GSALA L++DGR+V VIERD++EP R++GE +QPGG +L +LGL D
Sbjct: 122 PEVIIVGSGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGELLQPGGYRVLQELGLGDT 181
Query: 1454 LEGIDAQKSTGIAL--FKDGKETVASYPV-DTNFPYEPSGRFFQNGRFVQRLRQKASSLP 1284
+EG++A G + ++ E YP+ +TN SG F +GRF+ LR+ A + P
Sbjct: 182 VEGLNAHHIHGYIVHDYESRSEVQIPYPLSETN--QVQSGIAFHHGRFIMSLRKAAMAEP 239
Query: 1283 NVRLEEGTVRSLIEEKGVVKGVTYKN-SSGEETTAFAPLTVVCDGCHSNLRRSLNDNNAE 1107
NV+ EG V L+EE V GV YK+ +G+ APLTVV DG S R+SL +
Sbjct: 240 NVKFIEGVVLQLLEEDDAVIGVQYKDKETGDTKELHAPLTVVADGLFSKFRKSLISSKVS 299
Query: 1106 VTAYEIGYISRNCRLEQPDKLHLIMAKPSFAMLYQVSSTDVRCNFELLSNNLPSVSNGEM 927
V+++ +G++ ++ +P+ L++ PS ++YQ+SS++ R + + LP +
Sbjct: 300 VSSHFVGFLMKDAPQFKPNFAELVLVNPSPVLIYQISSSETRVLVD-IRGELPR----NL 354
Query: 926 ASFVKNSIAPQVPLKFRKTFLKGLDEGSHIKITQAKRMPATLSRKKGVIVLGDAFNMRHP 747
++ I PQ+P +++FL+ G ++ A +P + K+GV++LGDA+N+RHP
Sbjct: 355 REYMAEQIYPQLPEHLKESFLEASQNG-RLRTMPASFLPPSSVNKRGVLILGDAYNLRHP 413
Query: 746 VIASGMMVLLSDILILSRLLKPLDSLGDENKVSEVMKSFYVLRK-PMSATVNTLGNSFWQ 570
+ GM V L DI + +LLK + L D+ + + KSF+ RK S VN L + ++
Sbjct: 414 LTGGGMTVALKDIKLWRQLLKDIPDLYDDAAIFQAKKSFFWSRKRTHSFVVNVLAQALYE 473
Query: 569 VLIASTDEAKEAMRQGCFDYLSSGGFRTSGLMAVFGGMNPRPLSLIYHLSVITL 408
L ++TD++ +R+ CF Y GG +G + + ++P PL LI H + +
Sbjct: 474 -LFSATDDSLHQLRKACFLYFKLGGECVTGPVGLLSILSPHPLVLIRHFFSVAI 526
>sp|Q9C1W3|ERG1_SCHPO Probable squalene monooxygenase OS=Schizosaccharomyces
pombe GN=SPBC713.12 PE=2 SV=1
Length = 457
Score = 255 bits (650), Expect = 1e-066
Identities = 157/454 (34%), Positives = 242/454 (53%), Gaps = 15/454 (3%)
Frame = -1
Query: 1631 DVIIVGAGVGGSALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQDCL 1452
D+II+GAG+ G AL AL + GR+V V+ERDM EP R++GE +QPGG L K+G+ D +
Sbjct: 7 DIIIIGAGITGCALGAALGRQGRKVLVLERDMSEPDRIVGELLQPGGIEALEKIGIADAV 66
Query: 1451 EGIDAQKSTGIALFKDGKETVASYPVDTN-FPYEPSGRFFQNGRFVQRLRQKASSLPNVR 1275
EGID Q ++G +F YP N Y+ G F GRFV LR+ +S PNV
Sbjct: 67 EGIDGQWTSGYQIFYGDSNVSVPYPSKPNGGAYQGIG--FHYGRFVMNLRKALTSTPNVT 124
Query: 1274 LEEGTVRSLIEEK--GVVKGVTYKNSSGEETTAF-APLTVVCDGCHSNLRRSLNDNNAEV 1104
+ E TV L+ ++ V+ GV + E + APLT+VCDGC S R++ D+ +V
Sbjct: 125 VTEATVNELLRDETGEVITGVVTSSKKSESPVEYKAPLTIVCDGCFSKFRKAFIDHPIQV 184
Query: 1103 TAYEIGYISRNCRLEQPDKLHLIMAKPSFAMLYQVSSTDVRCNFELLSNNLPSVSNGEMA 924
T + +G I N P + H+I++K + +LY +SST+ R NLP + +
Sbjct: 185 TDHFLGLILTNPDYIAPGRGHVILSKVAPMVLYPISSTEARILINYPGKNLPPMET--LK 242
Query: 923 SFVKNSIAPQVPLKFRKTFLKGLDEGSHIKITQAKRMPATLSRKKGVIVLGDAFNMRHPV 744
+V S P +P K R + LK ++ + +P T++R KG+I++GD+ NMRHP+
Sbjct: 243 KYVLESCVPNMPEKLRPS-LKAAVYNDRLRSMPNQFLPPTVNRTKGMILVGDSNNMRHPL 301
Query: 743 IASGMMVLLSDILILSRLLKP--LDSLGDENKVSEVMKSFYVLRKPMSATVNTLGNSFWQ 570
GM V D +LSR + P + L D ++ M F+ RK S +N L + ++
Sbjct: 302 TGGGMTVCFHDAYLLSRFISPSAVPDLLDYERILNQMNKFHWKRKGYSFVINVLSIALYK 361
Query: 569 VLIASTDEAKEAMRQGCFDYLSSGGFRTSGLMAVFGGMNPRPLSLIYHLSVITLSSIGQL 390
L + +A+ GC DY GG G + + GG++ P LI H + L I Q
Sbjct: 362 -LFTPKNRYMKALESGCIDYFKRGGNCVEGPIRLLGGLDHSPSHLIGHFYAVCLYGIYQY 420
Query: 389 LSPFPT---PLRVWHSLRLFGLSLELLVPHLKAE 297
+ P P+R+ SL +F + +++P++ +E
Sbjct: 421 VLSGPALLMPVRIIESLLIFLQASLVIIPYILSE 454
>sp|P52020|ERG1_RAT Squalene monooxygenase OS=Rattus norvegicus GN=Sqle PE=2
SV=1
Length = 573
Score = 247 bits (630), Expect = 2e-064
Identities = 147/407 (36%), Positives = 235/407 (57%), Gaps = 12/407 (2%)
Frame = -1
Query: 1634 PDVIIVGAGVGGSALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQDC 1455
P+VII+G+GV GSALA L++DGR V VIERD++EP R++GE +QPGG +L +LGL D
Sbjct: 123 PEVIIIGSGVLGSALATVLSRDGRTVTVIERDLKEPDRILGECLQPGGYRVLRELGLGDT 182
Query: 1454 LEGIDAQKSTGIALF--KDGKETVASYPVDTNFPYEPSGRFFQNGRFVQRLRQKASSLPN 1281
+E ++A G + + E YPV N + SG F +G+F+ LR+ A + PN
Sbjct: 183 VESLNAHHIHGYVIHDCESRSEVQIPYPVSENNQVQ-SGVAFHHGKFIMSLRKAAMAEPN 241
Query: 1280 VRLEEGTVRSLIEEKGVVKGVTYKN-SSGEETTAFAPLTVVCDGCHSNLRRSLNDNNAEV 1104
V+ EG V L+EE V GV YK+ +G+ APLTVV DG S R++L N V
Sbjct: 242 VKFIEGVVLRLLEEDDAVIGVQYKDKETGDTKELHAPLTVVADGLFSKFRKNLISNKVSV 301
Query: 1103 TAYEIGYISRNCRLEQPDKLHLIMAKPSFAMLYQVSSTDVRCNFELLSNNLPSVSNGEMA 924
+++ +G+I ++ + + L++ PS ++YQ+S ++ R + + LP +
Sbjct: 302 SSHFVGFIMKDAPQFKANFAELVLVDPSPVLIYQISPSETRVLVD-IRGELPR----NLR 356
Query: 923 SFVKNSIAPQVPLKFRKTFLKGLDEGSHIKITQAKRMPATLSRKKGVIVLGDAFNMRHPV 744
++ I PQ+P +++FL+ + + ++ A +P + K+GV++LGDA+N+RHP+
Sbjct: 357 EYMTEQIYPQIPDHLKESFLEAC-QNARLRTMPASFLPPSSVNKRGVLLLGDAYNLRHPL 415
Query: 743 IASGMMVLLSDILILSRLLKPLDSLGDENKVSEVMKSFYVLRK-PMSATVNTLGNSFWQV 567
GM V L DI I +LLK + L D+ + + KSF+ RK S VN L + ++
Sbjct: 416 TGGGMTVALKDIKIWRQLLKDIPDLYDDAAIFQAKKSFFWSRKRSHSFVVNVLAQALYE- 474
Query: 566 LIASTDEAKEAMRQGCFDYLSSGGFRTSGLMAVFGGMNPRPLSLIYH 426
L ++TD++ +R+ CF Y GG +G + + ++P PL LI H
Sbjct: 475 LFSATDDSLRQLRKACFLYFKLGGECLTGPVGLLSILSPDPLLLIRH 521
>sp|O13306|ERG1_CANGA Squalene monooxygenase OS=Candida glabrata GN=ERG1 PE=3
SV=2
Length = 489
Score = 75 bits (183), Expect = 1e-012
Identities = 37/85 (43%), Positives = 53/85 (62%)
Frame = -1
Query: 1631 DVIIVGAGVGGSALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQDCL 1452
D +IVGAGV G +A ALA+ G++V ++ER+ +P R++GE MQPGG L LG+ +
Sbjct: 13 DALIVGAGVIGPCVATALARKGKKVLIVEREWSQPDRIVGELMQPGGLRALRSLGMIQSI 72
Query: 1451 EGIDAQKSTGIALFKDGKETVASYP 1377
IDA TG +F +G+ YP
Sbjct: 73 NNIDAYPVTGYTVFYNGEHVDIPYP 97
>sp|P32476|ERG1_YEAST Squalene monooxygenase OS=Saccharomyces cerevisiae GN=ERG1
PE=1 SV=2
Length = 496
Score = 74 bits (181), Expect = 2e-012
Identities = 36/91 (39%), Positives = 54/91 (59%)
Frame = -1
Query: 1631 DVIIVGAGVGGSALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQDCL 1452
D I++GAGV G +A LA+ G++V ++ERD P R++GE MQPGG L LG+ +
Sbjct: 20 DAIVIGAGVIGPCVATGLARKGKKVLIVERDWAMPDRIVGELMQPGGVRALRSLGMIQSI 79
Query: 1451 EGIDAQKSTGIALFKDGKETVASYPVDTNFP 1359
I+A TG +F +G++ YP + P
Sbjct: 80 NNIEAYPVTGYTVFFNGEQVDIPYPYKADIP 110
>sp|Q75F69|ERG1_ASHGO Squalene monooxygenase OS=Ashbya gossypii GN=ERG1 PE=3
SV=1
Length = 497
Score = 72 bits (174), Expect = 2e-011
Identities = 34/85 (40%), Positives = 54/85 (63%)
Frame = -1
Query: 1631 DVIIVGAGVGGSALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQDCL 1452
D I+VGAGV G +A ALA+ G++V ++ER+ +P R++GE MQP G L LG+ +
Sbjct: 21 DAIVVGAGVVGPCVATALARKGKKVLIVEREWSQPDRIVGELMQPAGVRALRSLGMVQAI 80
Query: 1451 EGIDAQKSTGIALFKDGKETVASYP 1377
IDA ++G + +G++ +YP
Sbjct: 81 NNIDACSTSGYTVIYNGEKISFAYP 105
>sp|Q92206|ERG1_CANAL Squalene monooxygenase OS=Candida albicans GN=ERG1 PE=3
SV=1
Length = 496
Score = 64 bits (155), Expect = 2e-009
Identities = 34/86 (39%), Positives = 49/86 (56%)
Frame = -1
Query: 1631 DVIIVGAGVGGSALAYALAKDGRRVHVIERDMREPVRMMGEFMQPGGRLLLSKLGLQDCL 1452
D II+GAGV G +A A A+ GR+V ++ERD +P R++GE MQP G L +LG+ +
Sbjct: 7 DAIIIGAGVIGPTIATAFARQGRKVLIVERDWSKPDRIVGELMQPAGIKALRELGMIKAI 66
Query: 1451 EGIDAQKSTGIALFKDGKETVASYPV 1374
I A TG + + YP+
Sbjct: 67 NNIRAVDCTGYYIKYYDETITIPYPL 92
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,861,281,767
Number of Sequences: 518415
Number of Extensions: 37861281767
Number of Successful Extensions: 273657778
Number of sequences better than 0.0: 0
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