BLASTX 7.6.2
Query= UN09694 /QuerySize=1088
(1087 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O60841|IF2P_HUMAN Eukaryotic translation initiation factor 5B... 144 1e-033
sp|Q05D44|IF2P_MOUSE Eukaryotic translation initiation factor 5B... 144 1e-033
sp|Q5RDE1|IF2P_PONAB Eukaryotic translation initiation factor 5B... 144 1e-033
sp|B2GUV7|IF2P_RAT Eukaryotic translation initiation factor 5B O... 144 1e-033
sp|P39730|IF2P_YEAST Eukaryotic translation initiation factor 5B... 110 2e-023
sp|Q10251|IF2P_SCHPO Eukaryotic translation initiation factor 5B... 110 3e-023
sp|A3MTU7|IF2P_PYRCJ Probable translation initiation factor IF-2... 97 1e-019
sp|B1YCQ7|IF2P_THENV Probable translation initiation factor IF-2... 92 6e-018
sp|Q3IMS5|IF2P_NATPD Probable translation initiation factor IF-2... 77 2e-013
sp|A5UJM9|IF2P_METS3 Probable translation initiation factor IF-2... 75 6e-013
sp|Q9Y9B3|IF2P_AERPE Probable translation initiation factor IF-2... 75 7e-013
sp|A2STM8|IF2P_METLZ Probable translation initiation factor IF-2... 59 4e-008
>sp|O60841|IF2P_HUMAN Eukaryotic translation initiation factor 5B OS=Homo
sapiens GN=EIF5B PE=1 SV=4
Length = 1220
Score = 144 bits (362), Expect = 1e-033
Identities = 82/220 (37%), Positives = 131/220 (59%), Gaps = 8/220 (3%)
Frame = +2
Query: 227 EEEGVYAIASTFGYLYELVLHLTSPEVNIPVTGLGVGPVTPGDIRKATQLRK---KHTTV 397
EE+GVY AST G L L+ L + EV P G+ +GPV D+ KA+ + + ++ +
Sbjct: 977 EEKGVYVQASTLGSLEALLEFLKTSEV--PYAGINIGPVHKKDVMKASVMLEHDPQYAVI 1034
Query: 398 LAFQVEVTPKASQQAQTLGVKIICGDTIQHLCQQFREFNKELGEDKKESESDVAQVSPCL 577
LAF V + A + A +LGV+I + I HL F ++ ++ + K+E +A V PC
Sbjct: 1035 LAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIA-VFPCK 1093
Query: 578 LSILPKCVLNKEDPIVLGVYVVEGFVKVGTPLCIPNRAFVNIGRVAWIQKDQRPVEFARE 757
+ ILP+ + N DPIV+GV V G VK GTP+C+P++ FV+IG V I+ + + V+ A++
Sbjct: 1094 IKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQVDVAKK 1153
Query: 758 GDMVIIKIVAADPKTQQGMLLGIDFDETDVLVSRTSRVAV 877
G V +KI ++ + + G F+ TD+LVS+ SR ++
Sbjct: 1154 GQEVCVKIEPIPGESPK--MFGRHFEATDILVSKISRQSI 1191
>sp|Q05D44|IF2P_MOUSE Eukaryotic translation initiation factor 5B OS=Mus
musculus GN=Eif5b PE=1 SV=2
Length = 1216
Score = 144 bits (362), Expect = 1e-033
Identities = 82/220 (37%), Positives = 131/220 (59%), Gaps = 8/220 (3%)
Frame = +2
Query: 227 EEEGVYAIASTFGYLYELVLHLTSPEVNIPVTGLGVGPVTPGDIRKATQLRK---KHTTV 397
EE+GVY AST G L L+ L + EV P G+ +GPV D+ KA+ + + ++ +
Sbjct: 973 EEKGVYVQASTLGSLEALLEFLKTSEV--PYAGINIGPVHKKDVMKASVMLEHDPQYAVI 1030
Query: 398 LAFQVEVTPKASQQAQTLGVKIICGDTIQHLCQQFREFNKELGEDKKESESDVAQVSPCL 577
LAF V + A + A +LGV+I + I HL F ++ ++ + K+E +A V PC
Sbjct: 1031 LAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIA-VFPCK 1089
Query: 578 LSILPKCVLNKEDPIVLGVYVVEGFVKVGTPLCIPNRAFVNIGRVAWIQKDQRPVEFARE 757
+ ILP+ + N DPIV+GV V G VK GTP+C+P++ FV+IG V I+ + + V+ A++
Sbjct: 1090 MKILPQYIFNSRDPIVIGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQVDVAKK 1149
Query: 758 GDMVIIKIVAADPKTQQGMLLGIDFDETDVLVSRTSRVAV 877
G V +KI ++ + + G F+ TD+LVS+ SR ++
Sbjct: 1150 GQEVCVKIEPIPGESPK--MFGRHFEATDILVSKISRQSI 1187
>sp|Q5RDE1|IF2P_PONAB Eukaryotic translation initiation factor 5B OS=Pongo
abelii GN=EIF5B PE=2 SV=2
Length = 1220
Score = 144 bits (362), Expect = 1e-033
Identities = 82/220 (37%), Positives = 131/220 (59%), Gaps = 8/220 (3%)
Frame = +2
Query: 227 EEEGVYAIASTFGYLYELVLHLTSPEVNIPVTGLGVGPVTPGDIRKATQLRK---KHTTV 397
EE+GVY AST G L L+ L + EV P G+ +GPV D+ KA+ + + ++ +
Sbjct: 977 EEKGVYVQASTLGSLEALLEFLKTSEV--PYAGINIGPVHKKDVMKASVMLEHDPQYAVI 1034
Query: 398 LAFQVEVTPKASQQAQTLGVKIICGDTIQHLCQQFREFNKELGEDKKESESDVAQVSPCL 577
LAF V + A + A +LGV+I + I HL F ++ ++ + K+E +A V PC
Sbjct: 1035 LAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEKFKHIA-VFPCK 1093
Query: 578 LSILPKCVLNKEDPIVLGVYVVEGFVKVGTPLCIPNRAFVNIGRVAWIQKDQRPVEFARE 757
+ ILP+ + N DPIV+GV V G VK GTP+C+P++ FV+IG V I+ + + V+ A++
Sbjct: 1094 MKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQVDVAKK 1153
Query: 758 GDMVIIKIVAADPKTQQGMLLGIDFDETDVLVSRTSRVAV 877
G V +KI ++ + + G F+ TD+LVS+ SR ++
Sbjct: 1154 GQEVCVKIEPIPGESPK--MFGRHFEATDILVSKISRQSI 1191
>sp|B2GUV7|IF2P_RAT Eukaryotic translation initiation factor 5B OS=Rattus
norvegicus GN=Eif5b PE=1 SV=1
Length = 1216
Score = 144 bits (362), Expect = 1e-033
Identities = 82/220 (37%), Positives = 131/220 (59%), Gaps = 8/220 (3%)
Frame = +2
Query: 227 EEEGVYAIASTFGYLYELVLHLTSPEVNIPVTGLGVGPVTPGDIRKATQLRK---KHTTV 397
EE+GVY AST G L L+ L + EV P G+ +GPV D+ KA+ + + ++ +
Sbjct: 973 EEKGVYVQASTLGSLEALLEFLKTSEV--PYAGINIGPVHKKDVMKASVMLEHDPQYAVI 1030
Query: 398 LAFQVEVTPKASQQAQTLGVKIICGDTIQHLCQQFREFNKELGEDKKESESDVAQVSPCL 577
LAF V + A + A +LGV+I + I HL F ++ ++ + K+E +A V PC
Sbjct: 1031 LAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIA-VFPCK 1089
Query: 578 LSILPKCVLNKEDPIVLGVYVVEGFVKVGTPLCIPNRAFVNIGRVAWIQKDQRPVEFARE 757
+ ILP+ + N DPIV+GV V G VK GTP+C+P++ FV+IG V I+ + + V+ A++
Sbjct: 1090 MKILPQYIFNSRDPIVIGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQVDVAKK 1149
Query: 758 GDMVIIKIVAADPKTQQGMLLGIDFDETDVLVSRTSRVAV 877
G V +KI ++ + + G F+ TD+LVS+ SR ++
Sbjct: 1150 GQEVCVKIEPIPGESPK--MFGRHFEATDILVSKISRQSI 1187
>sp|P39730|IF2P_YEAST Eukaryotic translation initiation factor 5B
OS=Saccharomyces cerevisiae GN=FUN12 PE=1 SV=2
Length = 1002
Score = 110 bits (274), Expect = 2e-023
Identities = 72/225 (32%), Positives = 121/225 (53%), Gaps = 15/225 (6%)
Frame = +2
Query: 233 EGVYAIASTFGYLYELVLHLTSPEVNIPVTGLGVGPVTPGDIRKATQLRKK---HTTVLA 403
+GV AST G L L+ L ++ IPV +G+GPV D+ KA+ + +K + +L
Sbjct: 753 KGVVVQASTLGSLEALLDFL--KDMKIPVMSIGLGPVYKRDVMKASTMLEKAPEYAVMLC 810
Query: 404 FQVEVTPKASQQAQTLGVKIICGDTIQHLCQQFREFNKELGEDKKESESDVAQVSPCLLS 583
F V+V +A Q A+ G+KI D I HL F + ++L E++++ D A + PC+L
Sbjct: 811 FDVKVDKEAEQYAEQEGIKIFNADVIYHLFDSFTAYQEKLLEERRKDFLDYA-IFPCVLQ 869
Query: 584 ILPKCVLNKEDPIVLGVYVVEGFVKVGTPLC-------IPNRAFVNIGRVAWIQKDQRPV 742
L ++NK P+++GV V+EG ++VGTP+C R + +G+V ++ + +PV
Sbjct: 870 TLQ--IINKRGPMIIGVDVLEGTLRVGTPICAVKTDPTTKERQTLILGKVISLEINHQPV 927
Query: 743 EFAREGDMVIIKIVAADPKTQQGMLLGIDFDETDVLVSRTSRVAV 877
+ ++G V + + Q + G DE D L S SR ++
Sbjct: 928 QEVKKGQTAAGVAVRLEDPSGQQPIWGRHVDENDTLYSLVSRRSI 972
>sp|Q10251|IF2P_SCHPO Eukaryotic translation initiation factor 5B
OS=Schizosaccharomyces pombe GN=SPAC56F8.03 PE=1 SV=1
Length = 1079
Score = 110 bits (273), Expect = 3e-023
Identities = 80/226 (35%), Positives = 122/226 (53%), Gaps = 21/226 (9%)
Frame = +2
Query: 236 GVYAIASTFGYLYELVLHLTSPEVNIPVTGLGVGPVTPGDI-RKATQLR--KKHTTVLAF 406
GV AST G L L+ L ++ IPV + +GPV D+ R AT L K++ +L F
Sbjct: 833 GVSVQASTLGSLEALLEFL--KQMKIPVASVNIGPVYKKDVMRCATMLEKAKEYALMLCF 890
Query: 407 QVEVTPKASQQAQTLGVKIICGDTIQHLCQQFREFNKELGEDKKESESDVAQVSPCLLSI 586
V+V A A+ LGVKI + I HL F K++ E K+E SDVA V PC+L
Sbjct: 891 DVKVDRDAEDLAEQLGVKIFSANVIYHLFDAFTAHQKKILEQKREESSDVA-VFPCVLKT 949
Query: 587 LPKCVLNKEDPIVLGVYVVEGFVKVGTPLC----IPN--RAFVNIGRVAWIQKDQRPVEF 748
+ NK DPI+LGV VVEG +++ TP+ +PN + +GRVA ++ + +PV+
Sbjct: 950 V--AAFNKRDPIILGVDVVEGVLRINTPIVAVKQLPNGEPQIIELGRVASLEMNHKPVDK 1007
Query: 749 AREGDM---VIIKIVAADPKTQQGMLLGIDFDETDVLVSRTSRVAV 877
++G V +K+ ++ + +L G E+D L S +R ++
Sbjct: 1008 VKKGQAGAGVAMKLESSGSQ----ILFGRQVTESDALYSHITRQSI 1049
>sp|A3MTU7|IF2P_PYRCJ Probable translation initiation factor IF-2 OS=Pyrobaculum
calidifontis (strain JCM 11548 / VA1) GN=infB PE=3 SV=1
Length = 592
Score = 97 bits (241), Expect = 1e-019
Identities = 66/191 (34%), Positives = 104/191 (54%), Gaps = 11/191 (5%)
Frame = +2
Query: 221 EEEEEGVYAIASTFGYLYELVLHLTSPEVNIPVTGLGVGPVTPGDIRKATQLRKK---HT 391
E ++EGV A TFG L ++L L + +PV VGP T D+ +A R+K +
Sbjct: 354 ESDKEGVIVRADTFGTLESIILFLR--QQGVPVRKADVGPPTHKDVVEAVLSRRKNPAYG 411
Query: 392 TVLAFQVEVTPKASQQAQTLGVKIICGDTIQHLCQQFREFNKELGEDKKESESDVAQVS- 568
+LAF V+V P+ +AQ+ GVKII G+ + + ++ +++ E+ K E ++Q++
Sbjct: 412 AILAFNVKVPPEVETEAQSSGVKIIRGEILYRIFDEYVKWSTEV--KTKTVEQVLSQLTR 469
Query: 569 PCLLSILPKCVLNKEDPIVLGVYVVEGFVKVGTPLCIPNRAFVNIGRVAWIQKDQRPVEF 748
P + ILP V + DP ++GV V+ G +K G L R +G+V IQ+ +PV
Sbjct: 470 PAKIQILPGYVFRRSDPAIVGVKVLAGTLKPGVTLAKDGR---EVGKVMQIQRQGKPVAE 526
Query: 749 AREGDMVIIKI 781
A GD V I I
Sbjct: 527 AVAGDEVAISI 537
>sp|B1YCQ7|IF2P_THENV Probable translation initiation factor IF-2
OS=Thermoproteus neutrophilus (strain DSM 2338 / JCM 9278 / V24Sta)
GN=infB PE=3 SV=1
Length = 589
Score = 92 bits (227), Expect = 6e-018
Identities = 63/191 (32%), Positives = 102/191 (53%), Gaps = 11/191 (5%)
Frame = +2
Query: 221 EEEEEGVYAIASTFGYLYELVLHLTSPEVNIPVTGLGVGPVTPGDIRKATQLRKK---HT 391
E + EGV A TFG L VL L + +P+ VGP T D+ +A R+K +
Sbjct: 352 ETDREGVIVRADTFGTLESTVLFLR--QQGVPIRKADVGPPTHKDVVEAVLSRRKNPAYG 409
Query: 392 TVLAFQVEVTPKASQQAQTLGVKIICGDTIQHLCQQFREFNKELGEDKKESESDVAQVS- 568
+LAF V+ P+ ++A + GVKII G+ + + ++ ++++E+ K E ++Q++
Sbjct: 410 VILAFNVKTPPEVEKEAMSSGVKIIRGEILYRIFDEYIKWSQEV--KTKTVEQILSQMTR 467
Query: 569 PCLLSILPKCVLNKEDPIVLGVYVVEGFVKVGTPLCIPNRAFVNIGRVAWIQKDQRPVEF 748
P + ILP V + +P ++GV V+ G +K G L + +GRV IQK +PV
Sbjct: 468 PGKIQILPGYVFRRSNPAIVGVKVLAGTIKPGVTLVKDGK---EVGRVMQIQKSGKPVGE 524
Query: 749 AREGDMVIIKI 781
A GD V + I
Sbjct: 525 AAAGDEVAVSI 535
>sp|Q3IMS5|IF2P_NATPD Probable translation initiation factor IF-2
OS=Natronomonas pharaonis (strain DSM 2160 / ATCC 35678) GN=infB PE=3
SV=1
Length = 602
Score = 77 bits (188), Expect = 2e-013
Identities = 59/191 (30%), Positives = 90/191 (47%), Gaps = 13/191 (6%)
Frame = +2
Query: 227 EEEGVYAIASTFGYLYELVLHLTSPEVNIPVTGLGVGPVTPGDIRKA-TQLRKKHTTVLA 403
EEEG+ A T G L + L E IP+ VG V P DI A T KH VLA
Sbjct: 360 EEEGIVVKADTLGSLEAIAAAL--EEAEIPIVRAEVGDVAPRDIAVASTAEEPKHEAVLA 417
Query: 404 FQVEVTPKASQQAQTLGVKIICGDTIQHLCQQFREFNKELGEDKKESESDVAQVSPCLLS 583
F V+V A ++A+ VK+ D I L +++ ++ E+ E ++E D + PC
Sbjct: 418 FNVDVLDDAEREAEEKDVKLFADDVIYQLVEEYDDYVTEIEEAQQEQILDKIE-RPCRFR 476
Query: 584 ILPKCVLNKEDPIVLGVYVVEGFVKVGTPLC-----IPNRAFVNIGRVAWIQKDQRPVEF 748
+L V + +P V+GV V+ G +K + + P R +G + +Q ++
Sbjct: 477 VLKDHVFRQSNPAVVGVEVLSGTLKRNSRVVKWDGNEPER----VGELKSLQDAGDDIDE 532
Query: 749 AREGDMVIIKI 781
AR G+ V I
Sbjct: 533 ARTGEQVAASI 543
>sp|A5UJM9|IF2P_METS3 Probable translation initiation factor IF-2
OS=Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861)
GN=infB PE=3 SV=1
Length = 596
Score = 75 bits (184), Expect = 6e-013
Identities = 48/154 (31%), Positives = 77/154 (50%), Gaps = 6/154 (3%)
Frame = +2
Query: 221 EEEEEGVYAIASTFGYLYELVLHLTSPEVNIPVTGLGVGPVTPGDIRK---ATQLRKKHT 391
+ E+EG+ A T G L +V L E++IP+ +G V DI A + H
Sbjct: 348 DTEDEGILVKADTIGSLEAVVKLLR--EMDIPIRAADIGDVNRRDIINSSIAYDENELHG 405
Query: 392 TVLAFQVEVTPKASQQAQTLGVKIICGDTIQHLCQQFREFNKELGEDKKESESDVAQVSP 571
++AF V+V P + + VK+ GD I + +++ E+ K+ EDKK+S D A + P
Sbjct: 406 AIIAFNVDVHPNSEEDLNNSEVKLFSGDVIYQILEEYEEWVKQKQEDKKKSFYD-AIIKP 464
Query: 572 CLLSILPKCVLNKEDPIVLGVYVVEGFVKVGTPL 673
LPK V + P ++G+ + G +K G L
Sbjct: 465 AKFVSLPKLVFRQSKPAIIGIESLSGTLKQGQQL 498
>sp|Q9Y9B3|IF2P_AERPE Probable translation initiation factor IF-2 OS=Aeropyrum
pernix GN=infB PE=3 SV=1
Length = 617
Score = 75 bits (183), Expect = 7e-013
Identities = 63/204 (30%), Positives = 97/204 (47%), Gaps = 11/204 (5%)
Frame = +2
Query: 188 VMRCLKKPQEE---EEEEEGVYAIASTFGYLYELVLHLTSPEVNIPVTGLGVGPVTPGDI 358
+M +++ EE E GV A T G L LV L +PV +GPV+ D+
Sbjct: 346 LMEAVQREIEELRFRTENIGVVVKADTLGTLEALVEALR--RRGVPVRLADIGPVSRSDV 403
Query: 359 RKATQLRKKHT---TVLAFQVEVTPKASQQAQTLGVKIICGDTIQHLCQQFREFNKELGE 529
A RK VLAF V+V P+A ++A GVKI I L + + E+ K+ E
Sbjct: 404 LDAAVTRKIDPYLGVVLAFNVKVLPEAEEEASRAGVKIFRESMIYKLIEDYEEWVKKEKE 463
Query: 530 DKKESESDVAQVSPCLLSILPKCVLNKEDPIVLGVYVVEGFVKVGTPLCIPNRAFVNIGR 709
++ + + + P ILP V + DP ++GV V+ G ++ G P + + +GR
Sbjct: 464 AERLKALN-SLIRPGKFRILPGYVFRRSDPAIVGVEVLGGVIRPGYP--VMDSQGRELGR 520
Query: 710 VAWIQKDQRPVEFAREGDMVIIKI 781
+ I+ R +E AR G V + I
Sbjct: 521 IMAIKDRDRSLEEARLGAAVAVSI 544
>sp|A2STM8|IF2P_METLZ Probable translation initiation factor IF-2
OS=Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
GN=infB PE=3 SV=1
Length = 589
Score = 59 bits (142), Expect = 4e-008
Identities = 56/203 (27%), Positives = 89/203 (43%), Gaps = 14/203 (6%)
Frame = +2
Query: 200 LKKPQEEEEE------EEGVYAIASTFGYLYELVLHLTSPEVNIPVTGLGVGPVTPGDIR 361
L K EE +E + GV A T G L L L + NIP+ VGP++ D+
Sbjct: 333 LAKINEEMQEINIKLSDVGVSVRADTIGALEALSNELDAK--NIPIMRASVGPLSRRDLI 390
Query: 362 KATQLRKK-HTTVLAFQVEVTPKASQQA--QTLGVKIICGDTIQHLCQQFREFNKELGED 532
+ +++ L F V + P A + + VKI I L + E+ E+
Sbjct: 391 DISVIKEDLFKVALCFNVPLLPDAEAMVRDEEVDVKIFSNRVIYKLLDDYLEWRDEMIRA 450
Query: 533 KKESESDVAQVSPCLLSILPKCVLNKEDPIVLGVYVVEGFVKVGTPLCIPNRAFVNIGRV 712
K+ + + V P SILP CV P V+GV V+ G ++ + I R +G +
Sbjct: 451 KEAKQFETV-VLPAKFSILPGCVFRMSGPAVVGVRVLGGTLR--PKVSIATRDGKIVGEI 507
Query: 713 AWIQKDQRPVEFAREGDMVIIKI 781
I+ ++ + A+EG V + I
Sbjct: 508 KQIKLNKETIGEAKEGAEVAVSI 530
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,366,676,449
Number of Sequences: 518415
Number of Extensions: 41366676449
Number of Successful Extensions: 294470065
Number of sequences better than 0.0: 0
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