BLASTX 7.6.2
Query= UN09956 /QuerySize=1171
(1170 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07943|ALDR_RAT Aldose reductase OS=Rattus norvegicus GN=Akr1... 257 1e-067
sp|P45376|ALDR_MOUSE Aldose reductase OS=Mus musculus GN=Akr1b1 ... 255 6e-067
sp|P15122|ALDR_RABIT Aldose reductase OS=Oryctolagus cuniculus G... 253 3e-066
sp|P16116|ALDR_BOVIN Aldose reductase OS=Bos taurus GN=AKR1B1 PE... 251 1e-065
sp|P80276|ALDR_PIG Aldose reductase OS=Sus scrofa GN=AKR1B1 PE=1... 250 1e-065
sp|P15121|ALDR_HUMAN Aldose reductase OS=Homo sapiens GN=AKR1B1 ... 248 7e-065
sp|Q7G764|NADO1_ORYSJ Probable NAD(P)H-dependent oxidoreductase ... 236 4e-061
sp|Q7G765|NADO2_ORYSJ Probable NAD(P)H-dependent oxidoreductase ... 233 2e-060
sp|P82125|AKCL2_PIG 1,5-anhydro-D-fructose reductase OS=Sus scro... 231 1e-059
sp|O08782|ALD2_CRIGR Aldose reductase-related protein 2 OS=Crice... 230 2e-059
sp|Q9DCT1|AKCL2_MOUSE 1,5-anhydro-D-fructose reductase OS=Mus mu... 229 4e-059
sp|P21300|ALD1_MOUSE Aldose reductase-related protein 1 OS=Mus m... 229 4e-059
sp|Q5U1Y4|AKCL2_RAT 1,5-anhydro-D-fructose reductase OS=Rattus n... 228 1e-058
sp|O60218|AK1BA_HUMAN Aldo-keto reductase family 1 member B10 OS... 226 4e-058
sp|P45377|ALD2_MOUSE Aldose reductase-related protein 2 OS=Mus m... 221 1e-056
sp|O74237|XYL1_CANTE NAD(P)H-dependent D-xylose reductase OS=Can... 126 4e-028
sp|Q9P430|XYL1_CANSH NAD(P)H-dependent D-xylose reductase OS=Can... 124 2e-027
sp|O13283|XYL1_CANTR NAD(P)H-dependent D-xylose reductase I,II O... 122 6e-027
sp|P31867|XYL1_PICST NAD(P)H-dependent D-xylose reductase OS=Pic... 122 6e-027
sp|P87039|XYL2_CANTR NADPH-dependent D-xylose reductase II,III O... 121 1e-026
>sp|P07943|ALDR_RAT Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3
Length = 316
Score = 257 bits (655), Expect = 1e-067
Identities = 132/279 (47%), Positives = 180/279 (64%), Gaps = 10/279 (3%)
Frame = -3
Query: 1060 ELNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFED 881
ELN G K+P++GLGTW++ PG V EAV A+ +GYRHIDCAQ+Y NEKE+G L++ ++
Sbjct: 6 ELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKE 65
Query: 880 NVVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGVKP 701
VVKR++LFI SKLWCT HD V A +TL DLQ DY+DLYL+HWP K G
Sbjct: 66 QVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPL 125
Query: 700 E---NLLP--VDIPSTWKAMEALHDSGKARAIGVSNFSTKKLADLLEL--ARVPPAVVQV 542
+ N++P D TW AME L D G +AIGVSNF+ ++ +L + PAV Q+
Sbjct: 126 DASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQI 185
Query: 541 ECHPSWRQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSD---VLKNLILNTVAEKLGKSP 371
ECHP Q KL E+C KG+ +TAYSPLGSP W K + +L++ + +A K K+
Sbjct: 186 ECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTT 245
Query: 370 AQVALRWGLQMGNSVLPKSTNEGRIRKNFEVFDWSIPDD 254
AQV +R+ +Q V+PKS RI +NF+VFD+ + ++
Sbjct: 246 AQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNE 284
>sp|P45376|ALDR_MOUSE Aldose reductase OS=Mus musculus GN=Akr1b1 PE=1 SV=3
Length = 316
Score = 255 bits (650), Expect = 6e-067
Identities = 131/279 (46%), Positives = 178/279 (63%), Gaps = 10/279 (3%)
Frame = -3
Query: 1060 ELNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFED 881
ELN G K+P++GLGTW++ PG V EAV A+ +GYRHIDCAQ+Y NEKE+G L++ ++
Sbjct: 6 ELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDLGYRHIDCAQVYQNEKEVGVALQEKLKE 65
Query: 880 NVVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGVKP 701
VVKR++LFI SKLWCT HD V A +TL DLQ DY+DLYL+HWP K G
Sbjct: 66 QVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPL 125
Query: 700 E---NLLP--VDIPSTWKAMEALHDSGKARAIGVSNFSTKKLADLLEL--ARVPPAVVQV 542
+ N++P D TW AME L D G + IGVSNF+ ++ +L + PAV Q+
Sbjct: 126 DASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQI 185
Query: 541 ECHPSWRQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSD---VLKNLILNTVAEKLGKSP 371
ECHP Q KL E+C SKG+ +TAYSPLGSP W K + +L++ + +A K K+
Sbjct: 186 ECHPYLTQEKLIEYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTT 245
Query: 370 AQVALRWGLQMGNSVLPKSTNEGRIRKNFEVFDWSIPDD 254
AQV +R+ +Q V+PKS RI +N +VFD+ + +
Sbjct: 246 AQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSE 284
>sp|P15122|ALDR_RABIT Aldose reductase OS=Oryctolagus cuniculus GN=AKR1B1 PE=2
SV=3
Length = 316
Score = 253 bits (644), Expect = 3e-066
Identities = 130/278 (46%), Positives = 179/278 (64%), Gaps = 10/278 (3%)
Frame = -3
Query: 1057 LNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFEDN 878
L GAK+P +GLGTW++ PG V EAV A+ +GYRHIDCA +Y NE E+G L++ ++
Sbjct: 7 LYNGAKMPILGLGTWKSPPGQVTEAVKTAIDLGYRHIDCAHVYQNENEVGVALQEKLKEQ 66
Query: 877 VVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGVKPE 698
VVKREELFI SKLWCT HD V A +TL DL+ DY+DLYL+HWP K GS +
Sbjct: 67 VVKREELFIVSKLWCTSHDKSLVKGACQKTLNDLKLDYLDLYLIHWPTGFKHGSEYFPLD 126
Query: 697 ---NLLP--VDIPSTWKAMEALHDSGKARAIGVSNFSTKKLADLLEL--ARVPPAVVQVE 539
N++P D TW+AME L D G ++IGVSNF+ ++ +L + PAV Q+E
Sbjct: 127 AAGNVIPSDTDFLDTWEAMEGLVDEGLVKSIGVSNFNHLQIERILNKPGLKYKPAVNQIE 186
Query: 538 CHPSWRQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSD---VLKNLILNTVAEKLGKSPA 368
CHP Q KL ++C SKG+ +TAYSPLGSP W K + +L++ + +A+K K+ A
Sbjct: 187 CHPYLTQEKLIQYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIADKHKKTTA 246
Query: 367 QVALRWGLQMGNSVLPKSTNEGRIRKNFEVFDWSIPDD 254
QV +R+ +Q V+PKS RI +NF+VFD+ + +
Sbjct: 247 QVLIRFPMQRNLVVIPKSVTPARIAENFQVFDFELSSE 284
>sp|P16116|ALDR_BOVIN Aldose reductase OS=Bos taurus GN=AKR1B1 PE=1 SV=1
Length = 315
Score = 251 bits (639), Expect = 1e-065
Identities = 130/275 (47%), Positives = 176/275 (64%), Gaps = 10/275 (3%)
Frame = -3
Query: 1057 LNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFEDN 878
L TGAK+P +GLGTW++ PG V EAV A+ +GYRHIDCA +Y NE E+G L+ ++
Sbjct: 6 LYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQ 65
Query: 877 VVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGV--- 707
VVKRE+LFI SKLWCT HD V A +TL DL+ DY+DLYL+HWP K G
Sbjct: 66 VVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLD 125
Query: 706 KPENLLP--VDIPSTWKAMEALHDSGKARAIGVSNFSTKKLADLLEL--ARVPPAVVQVE 539
+ N++P D TW AME L D G +AIGVSNF+ ++ +L + PAV Q+E
Sbjct: 126 EDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIE 185
Query: 538 CHPSWRQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSD---VLKNLILNTVAEKLGKSPA 368
CHP Q KL ++C SKG+ +TAYSPLGSP W K + +L++ + +A+K K+ A
Sbjct: 186 CHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTA 245
Query: 367 QVALRWGLQMGNSVLPKSTNEGRIRKNFEVFDWSI 263
QV +R+ +Q V+PKS RI +NF+VFD+ +
Sbjct: 246 QVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFEL 280
>sp|P80276|ALDR_PIG Aldose reductase OS=Sus scrofa GN=AKR1B1 PE=1 SV=2
Length = 316
Score = 250 bits (638), Expect = 1e-065
Identities = 133/280 (47%), Positives = 181/280 (64%), Gaps = 11/280 (3%)
Frame = -3
Query: 1057 LNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFEDN 878
L TGAK+P +GLGTW++ PG V EAV A+ +GYRHIDCA +Y NE E+G L++ +
Sbjct: 7 LYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEKLQGQ 66
Query: 877 VVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGVKPE 698
VVKRE+LFI SKLWCTDH+ V A TL+DL+ DY+DLYL+HWP K G +
Sbjct: 67 VVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPFPLD 126
Query: 697 ---NLLP--VDIPSTWKAMEALHDSGKARAIGVSNFSTKKLADLLEL--ARVPPAVVQVE 539
N++P D TW+AME L D G +AIGVSNF+ ++ +L + PAV Q+E
Sbjct: 127 GDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIE 186
Query: 538 CHPSWRQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSD---VLKNLILNTVAEKLGKSPA 368
HP Q KL E+CKSKG+ +TAYSPLGSP W K + +L++ + +A K K+ A
Sbjct: 187 VHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTA 246
Query: 367 QVALRWGLQMGNSVLPKSTNEGRIRKNFEVFDWSI-PDDL 251
QV +R+ +Q V+PKS RI +NF+VFD+ + P+D+
Sbjct: 247 QVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDM 286
>sp|P15121|ALDR_HUMAN Aldose reductase OS=Homo sapiens GN=AKR1B1 PE=1 SV=3
Length = 316
Score = 248 bits (632), Expect = 7e-065
Identities = 129/275 (46%), Positives = 177/275 (64%), Gaps = 10/275 (3%)
Frame = -3
Query: 1057 LNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFEDN 878
LN GAK+P +GLGTW++ PG V EAV A+ +GYRHIDCA +Y NE E+G +++ +
Sbjct: 7 LNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQ 66
Query: 877 VVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGV--- 707
VVKREELFI SKLWCT H+ V A +TL DL+ DY+DLYL+HWP K G
Sbjct: 67 VVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLD 126
Query: 706 KPENLLPVD--IPSTWKAMEALHDSGKARAIGVSNFSTKKLADLLEL--ARVPPAVVQVE 539
+ N++P D I TW AME L D G +AIG+SNF+ ++ +L + PAV Q+E
Sbjct: 127 ESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIE 186
Query: 538 CHPSWRQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSD---VLKNLILNTVAEKLGKSPA 368
CHP Q KL ++C+SKG+ +TAYSPLGSP W K + +L++ + +A K K+ A
Sbjct: 187 CHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTA 246
Query: 367 QVALRWGLQMGNSVLPKSTNEGRIRKNFEVFDWSI 263
QV +R+ +Q V+PKS RI +NF+VFD+ +
Sbjct: 247 QVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFEL 281
>sp|Q7G764|NADO1_ORYSJ Probable NAD(P)H-dependent oxidoreductase 1 OS=Oryza
sativa subsp. japonica GN=Os10g0113000 PE=1 SV=1
Length = 321
Score = 236 bits (600), Expect = 4e-061
Identities = 131/307 (42%), Positives = 185/307 (60%), Gaps = 10/307 (3%)
Frame = -3
Query: 1039 IPSVGLGTWQASPGLVGE----AVAAAVKIGYRHIDCAQIYGNEKEIG-AVLKKLFEDNV 875
+P VG+GT A P E A+ A+++GYRH D A+IY E +G AV + + +
Sbjct: 16 MPRVGMGT-AAFPFTSSEDTTAAMLRAIELGYRHFDTARIYATEGCVGEAVAEAVRRGLI 74
Query: 874 VKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVG--VKP 701
R ++F+TSK+WC+D V A TL++L DYVDL L+HWPV + G+
Sbjct: 75 ASRADVFVTSKIWCSDLHAGRVVPAARETLRNLGMDYVDLLLVHWPVSLTPGNYDFPFPK 134
Query: 700 ENLLP-VDIPSTWKAMEALHDSGKARAIGVSNFSTKKLADLLELARVPPAVVQVECHPSW 524
E +LP D+ W+ ME H G ARAIGVSNFS KKL LL LA V PAV QVE +P W
Sbjct: 135 EVILPSFDMEGVWRGMEECHRLGLARAIGVSNFSAKKLEQLLSLAAVRPAVNQVEVNPMW 194
Query: 523 RQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSDVLKNLILNTVAEKLGKSPAQVALRWGL 344
+Q LRE C+ +GV L YSPLG+ GT W + V+ + +L +A GK+ AQ+ LRW
Sbjct: 195 QQRTLREVCRREGVQLCGYSPLGAKGTPWGSAAVMDSGVLQEIAGAKGKTLAQICLRWLY 254
Query: 343 QMGNSVLPKSTNEGRIRKNFEVFDWSIPDDLFAKFSDIEQARLLTAPFFVHETLSPYKSF 164
+ G+ +L K+ NE R+++N ++F+W + D+ + S + Q R L F+ + PYKS
Sbjct: 255 EQGDVLLVKTYNEKRMKENLDIFNWELTDEERERISQLPQLRGLPGLEFISDH-GPYKSV 313
Query: 163 EELWDGE 143
E+LWDG+
Sbjct: 314 EDLWDGD 320
>sp|Q7G765|NADO2_ORYSJ Probable NAD(P)H-dependent oxidoreductase 2 OS=Oryza
sativa subsp. japonica GN=Os10g0113100 PE=2 SV=1
Length = 322
Score = 233 bits (593), Expect = 2e-060
Identities = 129/306 (42%), Positives = 180/306 (58%), Gaps = 10/306 (3%)
Frame = -3
Query: 1039 IPSVGLGTWQASPGLVGE----AVAAAVKIGYRHIDCAQIYGNEKEIG-AVLKKLFEDNV 875
+P +G+GT A P E A+ A+++GYRH D A++Y E + AV + + V
Sbjct: 18 MPRIGMGT-AAFPFTSSEETTAALLRAIELGYRHFDTARLYATEGCVSEAVAEAVRRGLV 76
Query: 874 VKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGV---K 704
R ++F+TSKLWC+D V A TL++L DYVDL L+HWP + GS K
Sbjct: 77 ASRADVFVTSKLWCSDLHAGRVVPAARETLRNLGMDYVDLLLVHWPATVAPGSYDFPFPK 136
Query: 703 PENLLPVDIPSTWKAMEALHDSGKARAIGVSNFSTKKLADLLELARVPPAVVQVECHPSW 524
E D+ W+ ME H G ARAIGVSNFS KKL LL A V PA QVE +P W
Sbjct: 137 EEMAPAFDMEGVWRGMEECHRLGLARAIGVSNFSAKKLEQLLSFAVVRPAANQVEMNPMW 196
Query: 523 RQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSDVLKNLILNTVAEKLGKSPAQVALRWGL 344
+Q LRE C+ +GV L YSPLG+ GT W + V+ + +L+ +A+ GK+ AQ+ LRW
Sbjct: 197 QQRTLREVCRREGVQLCGYSPLGAKGTPWGSAAVMDSGVLHDIAQTKGKTLAQICLRWMY 256
Query: 343 QMGNSVLPKSTNEGRIRKNFEVFDWSIPDDLFAKFSDIEQARLLTAPFFVHETLSPYKSF 164
+ G+ +L K+ NE R+++N ++FDW + ++ K S + Q R LT FV + PYK
Sbjct: 257 EQGDVLLVKTYNENRMKENLDIFDWELTEEERDKISKLPQQRGLTGMQFVCDN-GPYKCV 315
Query: 163 EELWDG 146
E+LWDG
Sbjct: 316 EDLWDG 321
>sp|P82125|AKCL2_PIG 1,5-anhydro-D-fructose reductase OS=Sus scrofa GN=AKR1E2
PE=1 SV=2
Length = 301
Score = 231 bits (587), Expect = 1e-059
Identities = 127/300 (42%), Positives = 177/300 (59%), Gaps = 11/300 (3%)
Frame = -3
Query: 1042 KIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFEDNVVKRE 863
KIP +GLGTWQA+PG V EAV A+ GYRH DCA +Y NE E+G ++ ++ VV+RE
Sbjct: 3 KIPVLGLGTWQAAPGEVTEAVKVAIDTGYRHFDCAYLYHNENEVGVGIQAKIDEGVVRRE 62
Query: 862 ELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGVKPEN---- 695
+LFI SKLWCT H V A R+L+ L+ Y+DLYL+HWP+ K G V + +
Sbjct: 63 DLFIVSKLWCTCHKKSLVKSACTRSLKALKLQYLDLYLIHWPMGFKPGEVDLPVDRSGMI 122
Query: 694 -LLPVDIPSTWKAMEALHDSGKARAIGVSNFSTKKLADLLEL--ARVPPAVVQVECHPSW 524
D TW+AME L G RAIGVSNF+ ++L LL RV P Q+ECHP
Sbjct: 123 VASNTDFLDTWEAMEDLVIEGLVRAIGVSNFNHEQLERLLNKPNLRVKPVTNQIECHPYL 182
Query: 523 RQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSDVLKNLILNTVAEKLGKSPAQVALRWGL 344
Q KL FC+S+ V +TAY PLG +L++ ++ T+A+K GKS AQ+ +R+ +
Sbjct: 183 TQKKLISFCQSRNVSVTAYRPLGGSSE---GVPLLEDPVIQTIAQKHGKSAAQILIRFQI 239
Query: 343 QMGNSVLPKSTNEGRIRKNFEVFDWSIPDDLFAKFSDIEQ-ARLLTAPFFVHETLSPYKS 167
Q V+PKS N RI +NF+VFD+ + + +++ RL P + P+K+
Sbjct: 240 QRNVIVIPKSVNPKRILENFQVFDFELSEQDMTDLLGLDRNLRLSAFPIAENHKDYPFKA 299
>sp|O08782|ALD2_CRIGR Aldose reductase-related protein 2 OS=Cricetulus griseus
GN=AKR1B8 PE=1 SV=3
Length = 316
Score = 230 bits (586), Expect = 2e-059
Identities = 125/284 (44%), Positives = 174/284 (61%), Gaps = 10/284 (3%)
Frame = -3
Query: 1066 FFELNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLF 887
F EL+T AK+P VGLGTWQ+ PG V EAV A+ GYRHIDCA Y NE E+G +++
Sbjct: 4 FVELSTKAKMPIVGLGTWQSPPGQVKEAVKVAIDAGYRHIDCAYAYYNEHEVGEAIQEKI 63
Query: 886 EDNVVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGV 707
++ V+RE+LFI SKLW T + + + EA +TL DL+ DY+DLYL+HWP ++ G
Sbjct: 64 KEKAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKELF 123
Query: 706 KPE---NLLPVDIP--STWKAMEALHDSGKARAIGVSNFSTKKLADLLEL--ARVPPAVV 548
+ N+L I W+ ME L D G +A+GVSNF+ ++ +L + P
Sbjct: 124 PKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHKPVTN 183
Query: 547 QVECHPSWRQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSD---VLKNLILNTVAEKLGK 377
QVECHP Q KL E+C SKG+ +TAYSPLGSP W K + +L++ + +A K K
Sbjct: 184 QVECHPYLTQEKLIEYCHSKGITVTAYSPLGSPNRPWAKPEDPSLLEDPKIKEIAAKHKK 243
Query: 376 SPAQVALRWGLQMGNSVLPKSTNEGRIRKNFEVFDWSIPDDLFA 245
+ AQV +R+ +Q V+PKS RI +NF+VFD+ + D A
Sbjct: 244 TSAQVLIRFHIQRNVVVIPKSVTPARIHENFQVFDFQLSDQEMA 287
>sp|Q9DCT1|AKCL2_MOUSE 1,5-anhydro-D-fructose reductase OS=Mus musculus
GN=Akr1e2 PE=1 SV=1
Length = 301
Score = 229 bits (582), Expect = 4e-059
Identities = 127/293 (43%), Positives = 177/293 (60%), Gaps = 23/293 (7%)
Frame = -3
Query: 1039 IPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFEDNVVKREE 860
IP+VGLGTW+ASPG V +AV A+ +GYRH DCA +Y NE E+G + + ++ VVKRE+
Sbjct: 4 IPTVGLGTWKASPGEVTDAVKLAINLGYRHFDCAYLYHNESEVGMGISEKIKEGVVKRED 63
Query: 859 LFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGVKPENLLPVD 680
LF+ SKLWCT H V A TL+ L DY+DLYL+HWP+ K G E +P+D
Sbjct: 64 LFVVSKLWCTCHKKSLVKTACTNTLEALNLDYLDLYLIHWPMGFKPG------EKDIPLD 117
Query: 679 -----IPS------TWKAMEALHDSGKARAIGVSNFSTKKLADLLEL--ARVPPAVVQVE 539
IPS TW+AME L G + +GVSNF+ ++L LL+ RV P Q+E
Sbjct: 118 RNGKVIPSHTSFLDTWEAMEDLVFEGLVKNLGVSNFNHEQLERLLDKPGLRVRPITNQIE 177
Query: 538 CHPSWRQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSDVLKNLILNTVAEKLGKSPAQVA 359
CHP Q KL +FC + V +TAY PLG G + ++ + ++ +A+K GKSPAQ+
Sbjct: 178 CHPYLNQKKLIDFCHKRNVSVTAYRPLGGSGGGF---HLMDDTVIRKIAKKHGKSPAQIL 234
Query: 358 LRWGLQMGNSVLPKSTNEGRIRKNFEVFDWSIPD-DLFAKFSDIEQARLLTAP 203
+R+ +Q V+PKS RIR+N +VFD+ + + D+ S + RL T P
Sbjct: 235 IRFQIQRNLIVIPKSVTPSRIRENIQVFDFELTEKDMEELLSLDKNLRLATFP 287
>sp|P21300|ALD1_MOUSE Aldose reductase-related protein 1 OS=Mus musculus
GN=Akr1b7 PE=2 SV=4
Length = 316
Score = 229 bits (582), Expect = 4e-059
Identities = 121/281 (43%), Positives = 175/281 (62%), Gaps = 10/281 (3%)
Frame = -3
Query: 1066 FFELNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLF 887
F EL+T AK+P VGLGTW++SPG V EAV AA+ GYRHIDCA +Y NE E+G +++
Sbjct: 4 FVELSTKAKMPLVGLGTWKSSPGQVKEAVKAAIDAGYRHIDCAYVYHNENEVGEAIQEKI 63
Query: 886 EDNVVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGV 707
++N VKRE+LFI SKLW T + V +A TL DL+ DY+DLYL+HWP + G+ +
Sbjct: 64 KENAVKREDLFIVSKLWATFFEKSLVKKAFQNTLSDLKLDYLDLYLVHWPQGFQAGNALL 123
Query: 706 KPEN-----LLPVDIPSTWKAMEALHDSGKARAIGVSNFSTKKLADLLEL--ARVPPAVV 548
+N L W+AME L D G +A+G+SNF+ ++ LL + P
Sbjct: 124 PKDNKGKVLLSKSTFLDAWEAMEELVDQGLVKALGISNFNHFQIERLLNKPGLKHKPVTN 183
Query: 547 QVECHPSWRQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSD---VLKNLILNTVAEKLGK 377
Q+E HP Q KL ++C+SKG+ +TAYSPLGSP + K + V++ + +A K K
Sbjct: 184 QIESHPYLTQEKLIQYCQSKGIAVTAYSPLGSPDRPYAKPEDPVVMEIPKIKEIAAKHKK 243
Query: 376 SPAQVALRWGLQMGNSVLPKSTNEGRIRKNFEVFDWSIPDD 254
+ AQV +R+ +Q V+PKS RI++N +VFD+ + ++
Sbjct: 244 TVAQVLIRFHVQRNVVVIPKSVTPSRIQENLQVFDFQLSEE 284
>sp|Q5U1Y4|AKCL2_RAT 1,5-anhydro-D-fructose reductase OS=Rattus norvegicus
GN=Akr1e2 PE=2 SV=1
Length = 301
Score = 228 bits (579), Expect = 1e-058
Identities = 126/289 (43%), Positives = 175/289 (60%), Gaps = 13/289 (4%)
Frame = -3
Query: 1042 KIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFEDNVVKRE 863
+IP+VGLGTW+ASPG V +AV A+ +GYRH DCA +Y NE E+G +K+ ++ VVKR+
Sbjct: 3 QIPTVGLGTWKASPGEVTDAVKVAINLGYRHFDCAYLYHNESEVGMGIKEKIKEGVVKRD 62
Query: 862 ELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGVKPENLLPV 683
ELFI SKLWCT H V A TL+ L DY+DLYL+HWP+ K G + + V
Sbjct: 63 ELFIVSKLWCTYHKQSLVKTACINTLEALNLDYLDLYLIHWPMGFKPGDKDIPLDRSGKV 122
Query: 682 DIPS------TWKAMEALHDSGKARAIGVSNFSTKKLADLLEL--ARVPPAVVQVECHPS 527
IPS TW+AME L G + IGVSNF+ ++L LL R+ P Q+ECHP
Sbjct: 123 -IPSHTSFLDTWEAMEDLVIEGLVKNIGVSNFNHEQLDRLLNKPGLRIKPITNQIECHPY 181
Query: 526 WRQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSDVLKNLILNTVAEKLGKSPAQVALRWG 347
Q L +FC + V +TAY PLG ++ ++++ +A+K GKSPAQ+ +R+
Sbjct: 182 LNQKSLIDFCHGRNVSVTAYRPLGGSRD---GVHLMDDIVIRKIAKKHGKSPAQILIRFQ 238
Query: 346 LQMGNSVLPKSTNEGRIRKNFEVFDWSIPD-DLFAKFSDIEQARLLTAP 203
+Q V+PKS N RIR+N +VFD+ + + D+ S + RL T P
Sbjct: 239 IQRNLIVIPKSVNPSRIRENIQVFDFELTEKDMEELLSLDKNLRLATFP 287
>sp|O60218|AK1BA_HUMAN Aldo-keto reductase family 1 member B10 OS=Homo sapiens
GN=AKR1B10 PE=1 SV=1
Length = 316
Score = 226 bits (574), Expect = 4e-058
Identities = 124/290 (42%), Positives = 173/290 (59%), Gaps = 22/290 (7%)
Frame = -3
Query: 1066 FFELNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLF 887
F EL+T AK+P VGLGTW++ G V EAV A+ GYRHIDCA +Y NE E+G +++
Sbjct: 4 FVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKI 63
Query: 886 EDNVVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGV 707
++ VKRE+LFI SKLW T + V +A +TL+DL+ Y+D+YL+HWP K G
Sbjct: 64 QEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSG---- 119
Query: 706 KPENLLPVD-----------IPSTWKAMEALHDSGKARAIGVSNFSTKKLADLLEL--AR 566
++L P D W+AME L D G +A+GVSNFS ++ LL +
Sbjct: 120 --DDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLK 177
Query: 565 VPPAVVQVECHPSWRQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSD---VLKNLILNTV 395
P QVECHP Q KL ++C SKG+ +TAYSPLGSP W K + +L++ + +
Sbjct: 178 YKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEI 237
Query: 394 AEKLGKSPAQVALRWGLQMGNSVLPKSTNEGRIRKNFEVFDWSIPDDLFA 245
A K K+ AQV +R+ +Q V+PKS RI +N +VFD+ + D+ A
Sbjct: 238 AAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMA 287
>sp|P45377|ALD2_MOUSE Aldose reductase-related protein 2 OS=Mus musculus
GN=Akr1b8 PE=1 SV=2
Length = 316
Score = 221 bits (561), Expect = 1e-056
Identities = 122/290 (42%), Positives = 173/290 (59%), Gaps = 22/290 (7%)
Frame = -3
Query: 1066 FFELNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLF 887
F EL+T AK+P VGLGTW++ P V EAV AA+ GYRHIDCA Y NE E+G +++
Sbjct: 4 FVELSTKAKMPIVGLGTWKSPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQEKI 63
Query: 886 EDNVVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMKKGSVGV 707
++ V+RE+LFI SKLW T + + + EA +TL DL+ DY+DLYL+HWP ++ G
Sbjct: 64 KEKAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPG---- 119
Query: 706 KPENLLPVD-----------IPSTWKAMEALHDSGKARAIGVSNFSTKKLADLLEL--AR 566
+ L P D W+ ME L D G +A+GVSNF+ ++ LL +
Sbjct: 120 --KELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLK 177
Query: 565 VPPAVVQVECHPSWRQTKLREFCKSKGVHLTAYSPLGSPGTTWLKSD---VLKNLILNTV 395
P QVECHP Q KL ++C SKG+ +TAYSPLGSP K + +L++ + +
Sbjct: 178 HKPVTNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSPDRPSAKPEDPSLLEDPKIKEI 237
Query: 394 AEKLGKSPAQVALRWGLQMGNSVLPKSTNEGRIRKNFEVFDWSIPDDLFA 245
A K K+ AQV +R+ +Q V+PKS RI++N +VFD+ + D+ A
Sbjct: 238 AAKHEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMA 287
>sp|O74237|XYL1_CANTE NAD(P)H-dependent D-xylose reductase OS=Candida tenuis
GN=XYL1 PE=1 SV=1
Length = 322
Score = 126 bits (315), Expect = 4e-028
Identities = 58/120 (48%), Positives = 85/120 (70%)
Frame = -3
Query: 1084 MANAIRFFELNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGA 905
M+ +I +L++G +PS+G G W+ + GE V A+K GYR D A+ YGNEKE+G
Sbjct: 1 MSASIPDIKLSSGHLMPSIGFGCWKLANATAGEQVYQAIKAGYRLFDGAEDYGNEKEVGD 60
Query: 904 VLKKLFEDNVVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMK 725
+K+ ++ +VKREE+F+TSKLW HDP++V ALN+TL DL+ DYVDL+L+H+P+ K
Sbjct: 61 GVKRAIDEGLVKREEIFLTSKLWNNYHDPKNVETALNKTLADLKVDYVDLFLIHFPIAFK 120
>sp|Q9P430|XYL1_CANSH NAD(P)H-dependent D-xylose reductase OS=Candida shehatae
GN=XYL1 PE=3 SV=1
Length = 323
Score = 124 bits (310), Expect = 2e-027
Identities = 54/113 (47%), Positives = 80/113 (70%)
Frame = -3
Query: 1063 FELNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFE 884
F+LN G ++PS+G G W+ + V A+K GYR D A+ YGNE+E+G +K+ +
Sbjct: 9 FKLNNGLEMPSIGFGCWKLDKSTAADQVYNAIKAGYRLFDGAEDYGNEQEVGEGVKRAID 68
Query: 883 DNVVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMK 725
+ +V REE+F+TSKLW HDP++V ALN+TL+DL+ DYVDL+L+H+P+ K
Sbjct: 69 EGIVTREEIFLTSKLWNNYHDPKNVETALNKTLKDLKVDYVDLFLIHFPIAFK 121
>sp|O13283|XYL1_CANTR NAD(P)H-dependent D-xylose reductase I,II OS=Candida
tropicalis GN=xyrA PE=3 SV=1
Length = 324
Score = 122 bits (305), Expect = 6e-027
Identities = 55/112 (49%), Positives = 78/112 (69%)
Frame = -3
Query: 1060 ELNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFED 881
+LN+G ++P VG G W+ + + + A+K GYR D A+ YGNEKE+G + + ++
Sbjct: 11 KLNSGYEMPLVGFGCWKVTNATAADQIYNAIKTGYRLFDGAEDYGNEKEVGEGINRAIKE 70
Query: 880 NVVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMK 725
+VKREELFITSKLW HDP++V ALN+TL DL DYVDL+L+H+P+ K
Sbjct: 71 GLVKREELFITSKLWNNFHDPKNVETALNKTLSDLNLDYVDLFLIHFPIAFK 122
>sp|P31867|XYL1_PICST NAD(P)H-dependent D-xylose reductase OS=Pichia stipitis
GN=XYL1 PE=3 SV=1
Length = 318
Score = 122 bits (305), Expect = 6e-027
Identities = 57/112 (50%), Positives = 77/112 (68%)
Frame = -3
Query: 1060 ELNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFED 881
+LN+G +P+VG G W+ E + A+K GYR D A+ Y NEK +GA +KK ++
Sbjct: 5 KLNSGYDMPAVGFGCWKVDVDTCSEQIYRAIKTGYRLFDGAEDYANEKLVGAGVKKAIDE 64
Query: 880 NVVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMK 725
+VKRE+LF+TSKLW H P +V +ALNRTL DLQ DYVDL+L+H+PV K
Sbjct: 65 GIVKREDLFLTSKLWNNYHHPDNVEKALNRTLSDLQVDYVDLFLIHFPVTFK 116
>sp|P87039|XYL2_CANTR NADPH-dependent D-xylose reductase II,III OS=Candida
tropicalis GN=xyrB PE=1 SV=1
Length = 324
Score = 121 bits (303), Expect = 1e-026
Identities = 55/112 (49%), Positives = 78/112 (69%)
Frame = -3
Query: 1060 ELNTGAKIPSVGLGTWQASPGLVGEAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKLFED 881
+LN+G ++P VG G W+ + + + A+K GYR D A+ YGNEKE+G + + ++
Sbjct: 11 KLNSGYEMPLVGFGCWKVNNETAADQIYNAIKTGYRLFDGAEDYGNEKEVGEGINRAIKE 70
Query: 880 NVVKREELFITSKLWCTDHDPQDVPEALNRTLQDLQFDYVDLYLMHWPVRMK 725
+VKREELFITSKLW HDP++V ALN+TL DL DYVDL+L+H+P+ K
Sbjct: 71 GLVKREELFITSKLWNNFHDPKNVETALNKTLSDLNLDYVDLFLIHFPIAFK 122
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,366,676,449
Number of Sequences: 518415
Number of Extensions: 41366676449
Number of Successful Extensions: 294470065
Number of sequences better than 0.0: 0
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