BLASTX 7.6.2
Query= UN10395 /QuerySize=1573
(1572 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9M2P4|SINA2_ARATH E3 ubiquitin-protein ligase SINAT2 OS=Arab... 626 2e-178
sp|P93748|SINA1_ARATH Putative E3 ubiquitin-protein ligase SINAT... 573 1e-162
sp|Q84JL3|SINA3_ARATH E3 ubiquitin-protein ligase SINAT3 OS=Arab... 465 5e-130
sp|Q8S3N1|SINA5_ARATH E3 ubiquitin-protein ligase SINAT5 OS=Arab... 456 2e-127
sp|Q9STN8|SINA4_ARATH E3 ubiquitin-protein ligase SINAT4 OS=Arab... 448 5e-125
sp|P61092|SIA1A_MOUSE E3 ubiquitin-protein ligase SIAH1A OS=Mus ... 164 3e-039
sp|Q920M9|SIAH1_RAT E3 ubiquitin-protein ligase SIAH1 OS=Rattus ... 164 3e-039
sp|Q8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 OS=Homo ... 163 4e-039
sp|Q06985|SIA1B_MOUSE E3 ubiquitin-protein ligase SIAH1B OS=Mus ... 163 6e-039
sp|Q7ZVG6|SIAH1_DANRE E3 ubiquitin-protein ligase Siah1 OS=Danio... 161 1e-038
sp|Q86MW9|SINA_SCHMA E3 ubiquitin-protein ligase sina OS=Schisto... 161 1e-038
sp|Q8T3Y0|SINAL_DROME Probable E3 ubiquitin-protein ligase sinah... 156 7e-037
sp|P61093|SINA_DROER E3 ubiquitin-protein ligase sina OS=Drosoph... 154 2e-036
sp|P21461|SINA_DROME E3 ubiquitin-protein ligase sina OS=Drosoph... 154 2e-036
sp|Q8I147|SINA_DROWI E3 ubiquitin-protein ligase sina OS=Drosoph... 154 3e-036
sp|P29304|SINA_DROVI E3 ubiquitin-protein ligase sina OS=Drosoph... 152 8e-036
sp|A8X679|SIAH1_CAEBR E3 ubiquitin-protein ligase siah-1 OS=Caen... 144 3e-033
sp|Q965X6|SIAH1_CAEEL E3 ubiquitin-protein ligase siah-1 OS=Caen... 142 8e-033
sp|Q7SYL3|SIAH2_DANRE E3 ubiquitin-protein ligase Siah2 OS=Danio... 140 3e-032
sp|Q9I8X5|SIAH2_XENLA E3 ubiquitin-protein ligase siah2 OS=Xenop... 136 6e-031
>sp|Q9M2P4|SINA2_ARATH E3 ubiquitin-protein ligase SINAT2 OS=Arabidopsis
thaliana GN=SINAT2 PE=2 SV=1
Length = 308
Score = 626 bits (1613), Expect = 2e-178
Identities = 294/311 (94%), Positives = 298/311 (95%), Gaps = 3/311 (0%)
Frame = -3
Query: 1354 MAPGGSALKEVLESNSTRMDYEVKTTKVEVNNSNNNKPTKSSSAGIAKHGMHSNNGVYEL 1175
MAPGGSALKEV+ESNST MDYEVKT KVEV NNNKPTK SAGI K+G+HSNNGVYEL
Sbjct: 1 MAPGGSALKEVMESNSTGMDYEVKTAKVEV---NNNKPTKPGSAGIGKYGIHSNNGVYEL 57
Query: 1174 LECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYELGNIRCLALEKVAESLEVP 995
LECPVCTNLMYPPIHQCPNGHTLCSNCK RVQNTCPTCRYELGNIRCLALEKVAESLEVP
Sbjct: 58 LECPVCTNLMYPPIHQCPNGHTLCSNCKLRVQNTCPTCRYELGNIRCLALEKVAESLEVP 117
Query: 994 CRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLKDDHKVDMH 815
CRYQ+LGCHDIFPYYSKLKHEQHCRFRPY CPYAGSECSVTGDI TLVVHLKDDHKVDMH
Sbjct: 118 CRYQNLGCHDIFPYYSKLKHEQHCRFRPYTCPYAGSECSVTGDIPTLVVHLKDDHKVDMH 177
Query: 814 DGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFFRFMRDEN 635
DGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAF RFM DEN
Sbjct: 178 DGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFMGDEN 237
Query: 634 EAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDRQELK 455
EAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDRQELK
Sbjct: 238 EAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDRQELK 297
Query: 454 LRVTGRIWKEE 422
LRVTGRIWKEE
Sbjct: 298 LRVTGRIWKEE 308
>sp|P93748|SINA1_ARATH Putative E3 ubiquitin-protein ligase SINAT1
OS=Arabidopsis thaliana GN=SINAT1 PE=2 SV=1
Length = 305
Score = 573 bits (1476), Expect = 1e-162
Identities = 272/305 (89%), Positives = 280/305 (91%), Gaps = 6/305 (1%)
Frame = -3
Query: 1336 ALKEVLESNSTRMDYEVKTTKVEVNNSNNNKPTKSSSAGIAKHGMHSNNGVYELLECPVC 1157
ALKE LESNST +DYEVK KVE N+KPTKS S I K HS+NGVYELLECPVC
Sbjct: 7 ALKEALESNSTGVDYEVKMAKVEA----NSKPTKSGSGSIGK--FHSSNGVYELLECPVC 60
Query: 1156 TNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYELGNIRCLALEKVAESLEVPCRYQSL 977
TNLMYPPIHQCPNGHTLCS+CK RVQNTCPTCRYELGNIRCLALEKVAESLEVPCRYQ+L
Sbjct: 61 TNLMYPPIHQCPNGHTLCSSCKLRVQNTCPTCRYELGNIRCLALEKVAESLEVPCRYQNL 120
Query: 976 GCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLKDDHKVDMHDGCTFN 797
GC DIFPYYSKLKHEQHCRFR Y+CPYAGSECSVTGDI TLV HLKDDHKVDMHDGCTFN
Sbjct: 121 GCQDIFPYYSKLKHEQHCRFRSYSCPYAGSECSVTGDIPTLVDHLKDDHKVDMHDGCTFN 180
Query: 796 HRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFFRFMRDENEAKKFS 617
HRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAF RFM DENEAKKFS
Sbjct: 181 HRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFMGDENEAKKFS 240
Query: 616 YSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDRQELKLRVTGR 437
YSLEVGAH RKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSG D++ELKLRVTGR
Sbjct: 241 YSLEVGAHSRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGSDKEELKLRVTGR 300
Query: 436 IWKEE 422
IWKEE
Sbjct: 301 IWKEE 305
>sp|Q84JL3|SINA3_ARATH E3 ubiquitin-protein ligase SINAT3 OS=Arabidopsis
thaliana GN=SINAT3 PE=2 SV=1
Length = 326
Score = 465 bits (1195), Expect = 5e-130
Identities = 215/284 (75%), Positives = 241/284 (84%), Gaps = 2/284 (0%)
Frame = -3
Query: 1273 VEVNNSNNNKPTKSSSAGIAKHGMHSNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNC 1094
V ++ NN T ++A A + + V+ELLECPVCTN MYPPIHQC NGHTLCS C
Sbjct: 30 VSKHHHTNNNTTNVNAA--ASGLLPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTC 87
Query: 1093 KARVQNTCPTCRYELGNIRCLALEKVAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFR 914
KARV N CPTCR ELG+IRCLALEKVAESLE+PC++ SLGC +IFPYYSKLKHE C FR
Sbjct: 88 KARVHNRCPTCRQELGDIRCLALEKVAESLELPCKHMSLGCPEIFPYYSKLKHETVCNFR 147
Query: 913 PYACPYAGSECSVTGDISTLVVHLKDDHKVDMHDGCTFNHRYVKSNPHEVENATWMLTVF 734
PY+CPYAGSECSVTGDI LV HL+DDHKVDMH GCTFNHRYVKSNP EVENATWMLTVF
Sbjct: 148 PYSCPYAGSECSVTGDIPFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVENATWMLTVF 207
Query: 733 NCFGRQFCLHFEAFQLGMAPVYMAFFRFMRDENEAKKFSYSLEVGAHGRKLTWQGIPRSI 554
+CFG+ FCLHFEAFQLGMAPVYMAF RFM DE EA+ ++YSLEVG +GRKL W+G PRS+
Sbjct: 208 HCFGQYFCLHFEAFQLGMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSV 267
Query: 553 RDSHRKVRDSQDGLIIPRNLALYFSGGDRQELKLRVTGRIWKEE 422
RDSHRKVRDS DGLII RN+AL+FSGGDR+ELKLRVTGRIWKE+
Sbjct: 268 RDSHRKVRDSHDGLIIQRNMALFFSGGDRKELKLRVTGRIWKEQ 311
>sp|Q8S3N1|SINA5_ARATH E3 ubiquitin-protein ligase SINAT5 OS=Arabidopsis
thaliana GN=SINAT5 PE=1 SV=2
Length = 309
Score = 456 bits (1172), Expect = 2e-127
Identities = 210/283 (74%), Positives = 236/283 (83%), Gaps = 2/283 (0%)
Frame = -3
Query: 1270 EVNNSNNNKPTKSSSAGIAKHGMHSNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNCK 1091
E++ + TKS G A + VYELLECPVCTN MYPPIHQC NGHTLCS CK
Sbjct: 14 EIHQKHQFSSTKSQ--GGATVVISPATSVYELLECPVCTNSMYPPIHQCHNGHTLCSTCK 71
Query: 1090 ARVQNTCPTCRYELGNIRCLALEKVAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRP 911
+RV N CPTCR ELG+IRCLALEKVAESLE+PC+Y +LGC IFPYYSKLKHE C FRP
Sbjct: 72 SRVHNRCPTCRQELGDIRCLALEKVAESLELPCKYYNLGCLGIFPYYSKLKHESQCNFRP 131
Query: 910 YACPYAGSECSVTGDISTLVVHLKDDHKVDMHDGCTFNHRYVKSNPHEVENATWMLTVFN 731
Y+CPYAGSEC+ GDI+ LV HL+DDHKVDMH GCTFNHRYVKSNP EVENATWMLTVF
Sbjct: 132 YSCPYAGSECAAVGDITFLVAHLRDDHKVDMHTGCTFNHRYVKSNPREVENATWMLTVFQ 191
Query: 730 CFGRQFCLHFEAFQLGMAPVYMAFFRFMRDENEAKKFSYSLEVGAHGRKLTWQGIPRSIR 551
CFG+ FCLHFEAFQLGMAPVYMAF RFM DE++A+ ++YSLEVG GRK TW+G PRS+R
Sbjct: 192 CFGQYFCLHFEAFQLGMAPVYMAFLRFMGDEDDARNYTYSLEVGGSGRKQTWEGTPRSVR 251
Query: 550 DSHRKVRDSQDGLIIPRNLALYFSGGDRQELKLRVTGRIWKEE 422
DSHRKVRDS DGLII RN+AL+FSGGD++ELKLRVTGRIWKE+
Sbjct: 252 DSHRKVRDSHDGLIIQRNMALFFSGGDKKELKLRVTGRIWKEQ 294
>sp|Q9STN8|SINA4_ARATH E3 ubiquitin-protein ligase SINAT4 OS=Arabidopsis
thaliana GN=SINAT4 PE=2 SV=1
Length = 327
Score = 448 bits (1152), Expect = 5e-125
Identities = 203/255 (79%), Positives = 223/255 (87%)
Frame = -3
Query: 1186 VYELLECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYELGNIRCLALEKVAES 1007
VYELLECPVCT MYPPIHQC NGHTLCS CK RV N CPTCR ELG+IRCLALEKVAES
Sbjct: 58 VYELLECPVCTYSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAES 117
Query: 1006 LEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLKDDHK 827
LE+PC++ +LGC +IFPYYSKLKHE C FRPY+CPYAGSEC + GDI LV HL+DDHK
Sbjct: 118 LELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYSCPYAGSECGIVGDIPFLVAHLRDDHK 177
Query: 826 VDMHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFFRFM 647
VDMH G TFNHRYVKSNP EVENATWMLTVF+CFG+ FCLHFEAFQLGM PVYMAF RFM
Sbjct: 178 VDMHAGSTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMGPVYMAFLRFM 237
Query: 646 RDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDR 467
DE +A+ +SYSLEVG GRKLTW+G PRSIRDSHRKVRDS DGLII RN+AL+FSGGDR
Sbjct: 238 GDEEDARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDR 297
Query: 466 QELKLRVTGRIWKEE 422
+ELKLRVTG+IWKE+
Sbjct: 298 KELKLRVTGKIWKEQ 312
>sp|P61092|SIA1A_MOUSE E3 ubiquitin-protein ligase SIAH1A OS=Mus musculus
GN=Siah1a PE=1 SV=1
Length = 282
Score = 164 bits (413), Expect = 3e-039
Identities = 90/243 (37%), Positives = 132/243 (54%), Gaps = 8/243 (3%)
Frame = -3
Query: 1198 SNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYELGNIRCLALEK 1019
SNN + L ECPVC + + PPI QC +GH +CSNC+ ++ CPTCR LG+IR LA+EK
Sbjct: 31 SNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIRNLAMEK 89
Query: 1018 VAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLK 839
VA S+ PC+Y S GC P+ K +HE+ C FRPY+CP G+ C G + ++ HL
Sbjct: 90 VANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLM 149
Query: 838 DDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVY 668
HK + G N P V+ W++ + +CFG F L E + +
Sbjct: 150 HQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQEKYDGHQQF 205
Query: 667 MAFFRFMRDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLAL 488
A + + +A+ F+Y LE+ H R+LTW+ PRSI + + D L+ ++A
Sbjct: 206 FAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQ 265
Query: 487 YFS 479
F+
Sbjct: 266 LFA 268
>sp|Q920M9|SIAH1_RAT E3 ubiquitin-protein ligase SIAH1 OS=Rattus norvegicus
GN=Siah1 PE=1 SV=2
Length = 282
Score = 164 bits (413), Expect = 3e-039
Identities = 90/243 (37%), Positives = 132/243 (54%), Gaps = 8/243 (3%)
Frame = -3
Query: 1198 SNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYELGNIRCLALEK 1019
SNN + L ECPVC + + PPI QC +GH +CSNC+ ++ CPTCR LG+IR LA+EK
Sbjct: 31 SNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIRNLAMEK 89
Query: 1018 VAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLK 839
VA S+ PC+Y S GC P+ K +HE+ C FRPY+CP G+ C G + ++ HL
Sbjct: 90 VANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLM 149
Query: 838 DDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVY 668
HK + G N P V+ W++ + +CFG F L E + +
Sbjct: 150 HQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQEKYDGHQQF 205
Query: 667 MAFFRFMRDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLAL 488
A + + +A+ F+Y LE+ H R+LTW+ PRSI + + D L+ ++A
Sbjct: 206 FAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQ 265
Query: 487 YFS 479
F+
Sbjct: 266 LFA 268
>sp|Q8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 OS=Homo sapiens
GN=SIAH1 PE=1 SV=2
Length = 282
Score = 163 bits (411), Expect = 4e-039
Identities = 90/243 (37%), Positives = 131/243 (53%), Gaps = 8/243 (3%)
Frame = -3
Query: 1198 SNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYELGNIRCLALEK 1019
SNN + L ECPVC + + PPI QC +GH +CSNC+ ++ CPTCR LG+IR LA+EK
Sbjct: 31 SNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIRNLAMEK 89
Query: 1018 VAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLK 839
VA S+ PC+Y S GC P+ K HE+ C FRPY+CP G+ C G + ++ HL
Sbjct: 90 VANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLM 149
Query: 838 DDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVY 668
HK + G N P V+ W++ + +CFG F L E + +
Sbjct: 150 HQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQEKYDGHQQF 205
Query: 667 MAFFRFMRDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLAL 488
A + + +A+ F+Y LE+ H R+LTW+ PRSI + + D L+ ++A
Sbjct: 206 FAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQ 265
Query: 487 YFS 479
F+
Sbjct: 266 LFA 268
>sp|Q06985|SIA1B_MOUSE E3 ubiquitin-protein ligase SIAH1B OS=Mus musculus
GN=Siah1b PE=2 SV=2
Length = 282
Score = 163 bits (410), Expect = 6e-039
Identities = 89/243 (36%), Positives = 132/243 (54%), Gaps = 8/243 (3%)
Frame = -3
Query: 1198 SNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYELGNIRCLALEK 1019
SNN + L ECPVC + + PPI QC +GH +CSNC+ ++ CPTCR LG+IR LA+EK
Sbjct: 31 SNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIRNLAVEK 89
Query: 1018 VAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLK 839
VA S+ PC+Y + GC P+ K +HE+ C FRPY+CP G+ C G + ++ HL
Sbjct: 90 VANSVLFPCKYSASGCEITLPHTKKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLM 149
Query: 838 DDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVY 668
HK + G N P V+ W++ + +CFG F L E + +
Sbjct: 150 HQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQEKYDGHQQF 205
Query: 667 MAFFRFMRDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLAL 488
A + + +A+ F+Y LE+ H R+LTW+ PRSI + + D L+ ++A
Sbjct: 206 FAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQ 265
Query: 487 YFS 479
F+
Sbjct: 266 LFA 268
>sp|Q7ZVG6|SIAH1_DANRE E3 ubiquitin-protein ligase Siah1 OS=Danio rerio GN=siah1
PE=2 SV=2
Length = 282
Score = 161 bits (407), Expect = 1e-038
Identities = 89/243 (36%), Positives = 132/243 (54%), Gaps = 8/243 (3%)
Frame = -3
Query: 1198 SNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYELGNIRCLALEK 1019
SN+ + L ECPVC + + PPI QC +GH +CSNC+ ++ CPTCR LG+IR LA+EK
Sbjct: 31 SNSDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIRNLAMEK 89
Query: 1018 VAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLK 839
VA S+ PC+Y S GC P+ K +HE+ C FRPY+CP G+ C G + ++ HL
Sbjct: 90 VANSVLFPCKYASSGCEVTLPHTDKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLL 149
Query: 838 DDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVY 668
HK + G N P V+ W++ + +CFG F L E + +
Sbjct: 150 HQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQEKYDGHQQF 205
Query: 667 MAFFRFMRDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLAL 488
A + + +A+ F+Y LE+ H R+LTW+ PRSI + + D L+ ++A
Sbjct: 206 FAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQ 265
Query: 487 YFS 479
F+
Sbjct: 266 LFA 268
>sp|Q86MW9|SINA_SCHMA E3 ubiquitin-protein ligase sina OS=Schistosoma mansoni
GN=SINA PE=1 SV=1
Length = 371
Score = 161 bits (407), Expect = 1e-038
Identities = 86/236 (36%), Positives = 130/236 (55%), Gaps = 9/236 (3%)
Frame = -3
Query: 1177 LLECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYELGNIRCLALEKVAESLEV 998
L ECPVC + PPI QC +GH +C++C++++ ++CPTCR L NIR LA+EK+A S+
Sbjct: 123 LFECPVCMDYALPPIMQCQSGHIVCASCRSKL-SSCPTCRGNLDNIRNLAMEKLASSVLF 181
Query: 997 PCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLKDDHK--- 827
PC+Y + GC + F Y SK +HE C +RPY CP G+ C G++ ++ HL HK
Sbjct: 182 PCKYSTSGCPETFHYTSKSEHEAACEYRPYDCPCPGASCKWLGELEQVMPHLVHHHKSIT 241
Query: 826 VDMHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFFRFM 647
+ F + S P V+ W++ + +CFG F L E + ++ A + +
Sbjct: 242 TLQGEDIVFLATDI-SLPGAVD---WVM-MQSCFGHSFMLVLEKQERVPDQIFFALVQLI 296
Query: 646 RDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFS 479
+A +F Y LE+ H R+LTW+ PRSI D + D L+ N A F+
Sbjct: 297 GTRKQADQFVYRLELNGHRRRLTWEACPRSIHDGVQSAIAVSDCLVFDSNTAHSFA 352
>sp|Q8T3Y0|SINAL_DROME Probable E3 ubiquitin-protein ligase sinah OS=Drosophila
melanogaster GN=sinah PE=1 SV=2
Length = 351
Score = 156 bits (392), Expect = 7e-037
Identities = 87/235 (37%), Positives = 121/235 (51%), Gaps = 7/235 (2%)
Frame = -3
Query: 1177 LLECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYELGNIRCLALEKVAESLEV 998
LLECPVC + PPI QCP GH +CS C++++ CP CR + NIR LA+EKVA L
Sbjct: 103 LLECPVCFGYIMPPIMQCPRGHLICSTCRSKL-TICPVCRVFMTNIRSLAMEKVASKLIF 161
Query: 997 PCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLKDDHK-VD 821
PC++ GC Y K KHE+ C RPY CPY +CS G + + HL H+ V
Sbjct: 162 PCKHSHFGCRARLSYAEKTKHEEDCECRPYFCPYPDDKCSWQGPLRDVYQHLMSSHENVI 221
Query: 820 MHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGM-APVYMAFFRFMR 644
+G N + +E A V +C GR F L E LG Y R +
Sbjct: 222 TMEG---NDIIFLATNVNLEGALDWTMVQSCHGRHFLLSLEKINLGEDCQQYFTACRMIG 278
Query: 643 DENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFS 479
+A +F Y++ + A+ R L WQ PRSIR++ ++ D L++ ++ FS
Sbjct: 279 SMKDAAEFVYNISLEAYNRTLRWQSKPRSIRENFSSFTNA-DFLVLNKHTVELFS 332
>sp|P61093|SINA_DROER E3 ubiquitin-protein ligase sina OS=Drosophila erecta
GN=sina PE=3 SV=1
Length = 314
Score = 154 bits (388), Expect = 2e-036
Identities = 99/308 (32%), Positives = 152/308 (49%), Gaps = 13/308 (4%)
Frame = -3
Query: 1357 TMAPGGSALKEVLESNSTRMDYEVKTTKVEVNNSNNNKPTKSSSAGIAKHGMHSNNGVYE 1178
T A G+ V + ST N S+++ + SSAG GM ++ +
Sbjct: 13 TAAAAGAGATGVATNTSTSTGSSSAGNTSSANTSSSSS-SSLSSAGGGDAGMSAD--LTS 69
Query: 1177 LLECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYELGNIRCLALEKVAESLEV 998
L ECPVC + + PPI QC +GH +C +C++++ CPTCR L NIR LA+EKVA +++
Sbjct: 70 LFECPVCFDYVLPPILQCSSGHLVCVSCRSKL-TCCPTCRGPLANIRNLAMEKVASNVKF 128
Query: 997 PCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLKDDHK-VD 821
PC++ GC Y K +HE+ C RPY CP G+ C G + ++ HL HK +
Sbjct: 129 PCKHSGYGCTASLVYTEKTEHEETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSIT 188
Query: 820 MHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVYMAFFRFM 647
G N P V+ W++ + +CFG F L E + + A + +
Sbjct: 189 TLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLI 244
Query: 646 RDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDR 467
EA+ F Y LE+ + R+LTW+ +PRSI + + D L+ ++A F+ D
Sbjct: 245 GSRKEAENFVYRLELNGNRRRLTWEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFA--DN 302
Query: 466 QELKLRVT 443
L + VT
Sbjct: 303 GNLGINVT 310
>sp|P21461|SINA_DROME E3 ubiquitin-protein ligase sina OS=Drosophila
melanogaster GN=sina PE=1 SV=2
Length = 314
Score = 154 bits (388), Expect = 2e-036
Identities = 99/308 (32%), Positives = 152/308 (49%), Gaps = 13/308 (4%)
Frame = -3
Query: 1357 TMAPGGSALKEVLESNSTRMDYEVKTTKVEVNNSNNNKPTKSSSAGIAKHGMHSNNGVYE 1178
T A G+ V + ST N S+++ + SSAG GM ++ +
Sbjct: 13 TAAAAGAGATGVATNTSTSTGSSSAGNTSSANTSSSSS-SSLSSAGGGDAGMSAD--LTS 69
Query: 1177 LLECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYELGNIRCLALEKVAESLEV 998
L ECPVC + + PPI QC +GH +C +C++++ CPTCR L NIR LA+EKVA +++
Sbjct: 70 LFECPVCFDYVLPPILQCSSGHLVCVSCRSKL-TCCPTCRGPLANIRNLAMEKVASNVKF 128
Query: 997 PCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLKDDHK-VD 821
PC++ GC Y K +HE+ C RPY CP G+ C G + ++ HL HK +
Sbjct: 129 PCKHSGYGCTASLVYTEKTEHEETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSIT 188
Query: 820 MHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVYMAFFRFM 647
G N P V+ W++ + +CFG F L E + + A + +
Sbjct: 189 TLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLI 244
Query: 646 RDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDR 467
EA+ F Y LE+ + R+LTW+ +PRSI + + D L+ ++A F+ D
Sbjct: 245 GSRKEAENFVYRLELNGNRRRLTWEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFA--DN 302
Query: 466 QELKLRVT 443
L + VT
Sbjct: 303 GNLGINVT 310
>sp|Q8I147|SINA_DROWI E3 ubiquitin-protein ligase sina OS=Drosophila willistoni
GN=sina PE=3 SV=1
Length = 331
Score = 154 bits (387), Expect = 3e-036
Identities = 92/276 (33%), Positives = 144/276 (52%), Gaps = 12/276 (4%)
Frame = -3
Query: 1261 NSNNNKPTKSSSAGIAKHGMHSNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNCKARV 1082
N++++ + SSAG GM ++ + L ECPVC + + PPI QC +GH +C +C++++
Sbjct: 61 NTSSSSSSSLSSAGGGDAGMSAD--LTSLFECPVCFDYVLPPILQCSSGHLVCVSCRSKL 118
Query: 1081 QNTCPTCRYELGNIRCLALEKVAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYAC 902
CPTCR L NIR LA+EKVA +++ PC++ GC Y K +HE+ C RPY C
Sbjct: 119 -TCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEKTEHEETCECRPYLC 177
Query: 901 PYAGSECSVTGDISTLVVHLKDDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNC 728
P G+ C G + ++ HL HK + G N P V+ W++ + +C
Sbjct: 178 PCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSC 233
Query: 727 FGRQFCLHFEAFQ-LGMAPVYMAFFRFMRDENEAKKFSYSLEVGAHGRKLTWQGIPRSIR 551
FG F L E + + A + + EA+ F Y LE+ + R+LTW+ +PRSI
Sbjct: 234 FGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLTWEAMPRSIH 293
Query: 550 DSHRKVRDSQDGLIIPRNLALYFSGGDRQELKLRVT 443
+ + D L+ ++A F+ D L + VT
Sbjct: 294 EGVASAIHNSDCLVFDTSIAQLFA--DNGNLGINVT 327
>sp|P29304|SINA_DROVI E3 ubiquitin-protein ligase sina OS=Drosophila virilis
GN=sina PE=3 SV=1
Length = 314
Score = 152 bits (383), Expect = 8e-036
Identities = 91/276 (32%), Positives = 144/276 (52%), Gaps = 12/276 (4%)
Frame = -3
Query: 1261 NSNNNKPTKSSSAGIAKHGMHSNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNCKARV 1082
N++++ + SSAG GM ++ + L ECPVC + + PPI QC +GH +C +C++++
Sbjct: 44 NTSSSSSSSLSSAGGGDAGMSAD--LTSLFECPVCFDYVLPPILQCSSGHLVCVSCRSKL 101
Query: 1081 QNTCPTCRYELGNIRCLALEKVAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYAC 902
CPTCR L NIR LA+E+VA +++ PC++ GC Y K +HE+ C RPY C
Sbjct: 102 -TCCPTCRGPLANIRNLAMEEVASNVKFPCKHSGYGCTASLVYTEKTEHEETCECRPYLC 160
Query: 901 PYAGSECSVTGDISTLVVHLKDDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNC 728
P G+ C G + ++ HL HK + G N P V+ W++ + +C
Sbjct: 161 PCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSC 216
Query: 727 FGRQFCLHFEAFQ-LGMAPVYMAFFRFMRDENEAKKFSYSLEVGAHGRKLTWQGIPRSIR 551
FG F L E + + A + + EA+ F Y LE+ + R+LTW+ +PRSI
Sbjct: 217 FGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLTWEAMPRSIH 276
Query: 550 DSHRKVRDSQDGLIIPRNLALYFSGGDRQELKLRVT 443
+ + D L+ ++A F+ D L + VT
Sbjct: 277 EGVASAIHNSDCLVFDTSIAQLFA--DNGNLGINVT 310
>sp|A8X679|SIAH1_CAEBR E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis
briggsae GN=siah-1 PE=3 SV=2
Length = 434
Score = 144 bits (361), Expect = 3e-033
Identities = 87/276 (31%), Positives = 142/276 (51%), Gaps = 19/276 (6%)
Frame = -3
Query: 1264 NNSNNNKPTKSSS-AGIAKH----GMHSNNGVYELL---ECPVCTNLMYPPIHQCPNGHT 1109
+N+ ++ PT + + +A H G +++ E+L ECPVC M PP QCP+GH
Sbjct: 131 SNTTHSTPTVAQAMQSVAPHIPIVGAGADDSSAEILSVFECPVCLEYMLPPYMQCPSGHL 190
Query: 1108 LCSNCKARVQNTCPTCRYELGNIRCLALEKVAESLEVPCRYQSLGCHDIFPYYSKLKHEQ 929
+CSNC+ ++Q CPTCR ++R L LEK+A ++ PC++ + GC F + K+ HE+
Sbjct: 191 VCSNCRPKLQ-CCPTCRGPTPSVRNLGLEKIANTVRFPCKFSNSGCPLNFHHIDKMDHEE 249
Query: 928 HCRFRPYACPYAGSECSVTGDISTLVVHLKDDHK-VDMHDGCTFNHRYVKSN-PHEVENA 755
C +RPY+CP G+ C G ++ ++ HLK HK + G N P V+
Sbjct: 250 LCEYRPYSCPCPGASCKWQGALADVMDHLKKVHKSITTLQGEDIVFLATDINLPGAVD-- 307
Query: 754 TWMLTVFNCFGRQFCLHFEAFQ----LGMAPVYMAFFRFMRDENEAKKFSYSLEVGAHGR 587
W++ + +CF F L E + ++ A + + + EA F Y LE+ A+ R
Sbjct: 308 -WVM-MQSCFDYNFMLVLEKQEKYDPAQSTQMFYAVVQLIGSKKEADNFVYRLELSANRR 365
Query: 586 KLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFS 479
+++W+ PRSI + D L + A F+
Sbjct: 366 RMSWEATPRSIHEGVAFAIQQSDCLAFDTSAAQLFA 401
>sp|Q965X6|SIAH1_CAEEL E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis
elegans GN=siah-1 PE=1 SV=2
Length = 339
Score = 142 bits (357), Expect = 8e-033
Identities = 82/246 (33%), Positives = 124/246 (50%), Gaps = 11/246 (4%)
Frame = -3
Query: 1198 SNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYELGNIRCLALEK 1019
S+ + + ECPVC M PP QC +GH +CSNC+ ++Q CPTCR ++R L LEK
Sbjct: 80 SSAEILSVFECPVCLEYMLPPYMQCSSGHLVCSNCRPKLQ-CCPTCRGPTPSVRNLGLEK 138
Query: 1018 VAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLK 839
+A ++ PC++ + GC F + K +HE+ C FRPY CP G+ C G +S ++ HLK
Sbjct: 139 IANTVRFPCKFSTSGCPLNFHHADKTEHEELCEFRPYCCPCPGASCKWQGGLSDVMEHLK 198
Query: 838 DDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ----LGMA 677
HK + G N P V+ W++ + +CF F L E +
Sbjct: 199 KIHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFDYNFMLVLEKQEKYDPAQPT 254
Query: 676 PVYMAFFRFMRDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRN 497
++ A + + + EA F Y LE+ A R+++W+ PRSI + D L N
Sbjct: 255 QMFYAVVQLIGSKKEADNFVYRLELSASRRRMSWEATPRSIHEGVVVAIQQSDCLAFDSN 314
Query: 496 LALYFS 479
A F+
Sbjct: 315 AAQLFA 320
>sp|Q7SYL3|SIAH2_DANRE E3 ubiquitin-protein ligase Siah2 OS=Danio rerio
GN=siah2l PE=2 SV=2
Length = 331
Score = 140 bits (352), Expect = 3e-032
Identities = 87/249 (34%), Positives = 128/249 (51%), Gaps = 11/249 (4%)
Frame = -3
Query: 1177 LLECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPTCRYEL-GNIRCLALEKVAESLE 1001
L ECPVC + + PPI QC GH +C+ C+ ++ + CPTCR L +IR LA+EKVA +L
Sbjct: 86 LFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPTCRGPLTPSIRNLAMEKVASTLP 144
Query: 1000 VPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDISTLVVHLKDDHK-V 824
PC+Y S GC + K +HE+ C FRPY CP G+ C G + ++ HL HK +
Sbjct: 145 FPCKYSSAGCLLSLHHSEKPEHEEVCEFRPYTCPCPGASCKWQGSLEEVMPHLMHAHKSI 204
Query: 823 DMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQLGMA-PVYMAFFRF 650
G N P V+ W++ + +CFG F L E + + A
Sbjct: 205 TTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYEGHQQFFAIVLL 260
Query: 649 MRDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGD 470
+ +A+ F+Y LE+ + R+LTW+ PRSI D + D L+ ++A F+ D
Sbjct: 261 IGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTSIAHLFA--D 318
Query: 469 RQELKLRVT 443
L + VT
Sbjct: 319 NGNLGINVT 327
>sp|Q9I8X5|SIAH2_XENLA E3 ubiquitin-protein ligase siah2 OS=Xenopus laevis
GN=siah2 PE=2 SV=1
Length = 313
Score = 136 bits (341), Expect = 6e-031
Identities = 86/271 (31%), Positives = 132/271 (48%), Gaps = 11/271 (4%)
Frame = -3
Query: 1243 PTKSSSAGIAKHGMHSNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNCKARVQNTCPT 1064
P ++A I + + L ECPVC + + PPI QC GH +C+ C+ ++ + CPT
Sbjct: 44 PPAPTAAAITGPLSQQHQELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPT 102
Query: 1063 CRYEL-GNIRCLALEKVAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGS 887
CR L +IR LA+EKVA ++ PC+Y S GC + K +HE C +RPY+CP G+
Sbjct: 103 CRASLTPSIRNLAMEKVASAVLFPCKYASTGCSLSLHHTEKPEHEDICEYRPYSCPCPGA 162
Query: 886 ECSVTGDISTLVVHLKDDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQF 713
C G + ++ HL HK + G N P V+ W++ + CF F
Sbjct: 163 SCKWQGSLENVMQHLTHSHKSITTLQGEDIVFLATDINLPGAVD---WVMMQY-CFNHHF 218
Query: 712 CLHFEAFQLGMA-PVYMAFFRFMRDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRK 536
L E + + A + +A+ ++Y LE+ + R+LTW+ PRSI D
Sbjct: 219 MLVLEKQEKYEGHQQFFAIVLLIGTRKQAENYAYRLELNGNRRRLTWEATPRSIHDGVAA 278
Query: 535 VRDSQDGLIIPRNLALYFSGGDRQELKLRVT 443
+ D L+ +A F+ D L + VT
Sbjct: 279 AIMNSDCLVFDTAIAHLFA--DNGNLGINVT 307
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,893,998,746
Number of Sequences: 518415
Number of Extensions: 41893998746
Number of Successful Extensions: 306640000
Number of sequences better than 0.0: 0
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