BLASTX 7.6.2
Query= UN10508 /QuerySize=1637
(1636 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabi... 292 5e-078
sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase D... 209 6e-053
sp|Q55A09|Y9963_DICDI Probable serine/threonine-protein kinase D... 197 2e-049
sp|Q7T6X2|YR826_MIMIV Putative serine/threonine-protein kinase/r... 190 3e-047
sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase kinase kin... 183 4e-045
sp|Q3U1V8|M3K9_MOUSE Mitogen-activated protein kinase kinase kin... 182 7e-045
sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase ki... 180 3e-044
sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase ki... 180 4e-044
sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kina... 180 4e-044
sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kin... 179 5e-044
sp|Q95UN8|M3KSL_DROME Mitogen-activated protein kinase kinase ki... 176 4e-043
sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kin... 174 3e-042
sp|Q5UQG7|YR818_MIMIV Putative serine/threonine-protein kinase/r... 165 1e-039
sp|Q7T6Y2|YR831_MIMIV Putative serine/threonine-protein kinase/r... 163 3e-039
sp|Q54L00|LIMKA_DICDI Probable LIM domain-containing serine/thre... 162 1e-038
sp|Q54I36|PYK3_DICDI Dual specificity protein kinase pyk3 OS=Dic... 161 2e-038
sp|P0CD62|LIMKB_DICDI Probable LIM domain-containing serine/thre... 159 7e-038
sp|Q54TA1|DRKC_DICDI Probable serine/threonine-protein kinase dr... 156 7e-037
sp|Q54RZ7|Y1199_DICDI Probable serine/threonine-protein kinase D... 153 5e-036
sp|P00522|ABL_DROME Tyrosine-protein kinase Abl OS=Drosophila me... 150 4e-035
>sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabidopsis thaliana
GN=HT1 PE=1 SV=1
Length = 390
Score = 292 bits (747), Expect = 5e-078
Identities = 138/265 (52%), Positives = 184/265 (69%)
Frame = +3
Query: 603 EEWTIDLRKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEV 782
EEWT DL +L +G FA GA ++YRG YK VA+K++ P + E LEQQF+ EV
Sbjct: 77 EEWTADLSQLFIGNKFASGAHSRIYRGIYKQRAVAVKMVRIPTHKEETRAKLEQQFKSEV 136
Query: 783 SMLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDV 962
++LS L HPNIV+FI AC KP V CI+TEY G++R +L K++ ++ ++ ++ ALD+
Sbjct: 137 ALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDI 196
Query: 963 ARGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPE 1142
+RGM Y+H + IHRDLKS+NLL++ + +K+ADFG + +E Q GTYRWMAPE
Sbjct: 197 SRGMEYLHSQGVIHRDLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGNMGTYRWMAPE 256
Query: 1143 MIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPGDCLPVLG 1322
MI+ +PYT+KVDVYSFGIVLWEL T LLPFQ MT VQAAFAV + RP +P C P L
Sbjct: 257 MIKEKPYTRKVDVYSFGIVLWELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALA 316
Query: 1323 EIMTRCWDADPEVRPCFAEIVNLLE 1397
++ RCW +P RP F+ IV +LE
Sbjct: 317 HLIKRCWSENPSKRPDFSNIVAVLE 341
>sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase DDB_G0267514
OS=Dictyostelium discoideum GN=DDB_G0267514 PE=3 SV=1
Length = 916
Score = 209 bits (531), Expect = 6e-053
Identities = 108/272 (39%), Positives = 167/272 (61%), Gaps = 4/272 (1%)
Frame = +3
Query: 579 PTQGLANYEEWTIDLRKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQAL 758
P+Q + + I +L + +G FG +Y+G ++G VAIK ++ N Q L
Sbjct: 645 PSQQQQYFSDIEISFSELKISSKLGEGTFGVVYKGLWRGSSVAIKQIK--INEDVNNQVL 702
Query: 759 EQQFQQEVSMLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKL 938
E +F++E+++LS L+HPNIV + AC P LC +TEY GGS+ L ++ + + ++L
Sbjct: 703 E-EFRKELTILSRLRHPNIVLLMAACTAPPNLCFITEYLPGGSLYDALHSKKIK-MNMQL 760
Query: 939 AVKQALDVARGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETG 1118
K A+ +A+GM Y+H IHRD+KS NLL+ ++KI DFG+++++ ++ MT G
Sbjct: 761 YKKLAIQIAQGMNYLHLSGVIHRDIKSLNLLLDEHMNVKICDFGLSKLKSKSTEMTKSIG 820
Query: 1119 TYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVP 1298
+ WM+PE++ YT+KVDVY+FGI+LWEL TG LP+ + +VQ A AV + +RP +P
Sbjct: 821 SPIWMSPELLMGEDYTEKVDVYAFGIILWELGTGELPYSGLDSVQLALAVTTKSLRPPIP 880
Query: 1299 GDCLPVLGEIMTRCWDADPEVRPCFAEIVNLL 1394
L ++ CW DP RP F EI+NLL
Sbjct: 881 NAWPYQLSHLIQACWHQDPLKRPSFTEILNLL 912
>sp|Q55A09|Y9963_DICDI Probable serine/threonine-protein kinase DDB_G0272254
OS=Dictyostelium discoideum GN=DDB_G0272254 PE=3 SV=1
Length = 1331
Score = 197 bits (500), Expect = 2e-049
Identities = 109/273 (39%), Positives = 160/273 (58%), Gaps = 17/273 (6%)
Frame = +3
Query: 591 LANYEEWTIDLRKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQF 770
+ NY + ID +G F K+ +G +KG+DVA+K L N + + + Q+F
Sbjct: 1067 MINYSDIKID-------KEIGKGHFSKVLKGNWKGKDVAVKKLN--SNKDKAREEMIQEF 1117
Query: 771 QQEVSMLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKR---QNRAVPL--K 935
+ EV +L L+HPN+V G + PM CIV E+ G++ + + + Q +++ L
Sbjct: 1118 KAEVELLGSLQHPNLVTCYGYSLNPM--CIVMEFLPSGNLFELIHSKPSEQQQSIKLDST 1175
Query: 936 LAVKQALDVARGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPET 1115
L + A D+ARGM ++H RN IHRDLKS NLL+ +IKIAD G+AR T+ MT
Sbjct: 1176 LILAIAFDIARGMQHLHTRNIIHRDLKSSNLLMDKHFNIKIADLGIARETSFTQTMT-TI 1234
Query: 1116 GTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTV 1295
GT W APE+++H Y QK DVYS+ IVL+EL+TG P+Q + + A V ++G+RP +
Sbjct: 1235 GTVAWTAPEILRHESYNQKADVYSYAIVLYELLTGEEPYQGIPPMNAGILVASKGLRPEL 1294
Query: 1296 PGDCLPVLGEIMTRCWDADPEVRPCFAEIVNLL 1394
P +C P +++ CW DP RP F EI N L
Sbjct: 1295 PDNCDPNWKKLVVWCWSEDPNKRPSFEEITNYL 1327
>sp|Q7T6X2|YR826_MIMIV Putative serine/threonine-protein kinase/receptor R826
OS=Acanthamoeba polyphaga mimivirus GN=MIMI_R826 PE=4 SV=2
Length = 1657
Score = 190 bits (482), Expect = 3e-047
Identities = 98/274 (35%), Positives = 157/274 (57%), Gaps = 15/274 (5%)
Frame = +3
Query: 603 EEWTIDLRKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEK--AQALEQQFQQ 776
++W ID +L +G GAFG++++GT++G +VA+K++ SP+K + +E+ F+
Sbjct: 777 DDWEIDFHELELGEQLGTGAFGEVHKGTWRGTEVAVKMI-----SPDKTITKDIERNFKD 831
Query: 777 EVSMLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQAL 956
EV +++ L+HPN+V F+ A KP +CIV E+ GS+ L +P L VK A
Sbjct: 832 EVRVMTTLRHPNVVLFMAASTKPPKMCIVMEFMALGSLHDLLKNELIPDIPFALKVKIAY 891
Query: 957 DVARGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPE--TGTYRW 1130
++GM ++H HRDLKS NLL+ ++K++DFG+ + + + + PE GT +W
Sbjct: 892 QASKGMHFLHSSGITHRDLKSLNLLLDIKWNVKVSDFGLTKFKSDVKSINPEKFAGTIQW 951
Query: 1131 MAPEMIQHRPYTQKV--DVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVP-- 1298
APE++ + DVYSFGI++WELIT P+ M+ A +V+ RP +
Sbjct: 952 TAPEILSEDREVDYILSDVYSFGIIMWELITRDQPYFGMSPAAIAVSVIRDNYRPVISDQ 1011
Query: 1299 --GDCLPVLGEIMTRCWDADPEVRPCFAEIVNLL 1394
+ P E++T CW DP +RP F EI+ L
Sbjct: 1012 LRSEVAPEYIELLTSCWHFDPTIRPTFLEIMTRL 1045
>sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 OS=Homo
sapiens GN=MAP3K9 PE=1 SV=3
Length = 1104
Score = 183 bits (463), Expect = 4e-045
Identities = 102/289 (35%), Positives = 162/289 (56%), Gaps = 17/289 (5%)
Frame = +3
Query: 615 IDLRKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLS 794
ID +L + G FGK+YR + G++VA+K R + + +Q +E +QE + +
Sbjct: 139 IDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVK-AARHDPDEDISQTIE-NVRQEAKLFA 196
Query: 795 FLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGM 974
LKHPNI+ G C+K LC+V E+A+GG + + L+ + +P + V A+ +ARGM
Sbjct: 197 MLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS---GKRIPPDILVNWAVQIARGM 253
Query: 975 AYVHER---NFIHRDLKSDNLLI--------SADRSIKIADFGVARIEVQTEGMTPETGT 1121
Y+H+ IHRDLKS N+LI +++ +KI DFG+AR +T M+ GT
Sbjct: 254 NYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMS-AAGT 312
Query: 1122 YRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPG 1301
Y WMAPE+I+ +++ DV+S+G++LWEL+TG +PF+ + + A+ V + +P
Sbjct: 313 YAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPS 372
Query: 1302 DCLPVLGEIMTRCWDADPEVRPCFAEIVNLLEGAETEVMTTVRKARFRC 1448
C ++M CW+ DP RP F I++ L E + K F C
Sbjct: 373 TCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHC 421
>sp|Q3U1V8|M3K9_MOUSE Mitogen-activated protein kinase kinase kinase 9 OS=Mus
musculus GN=Map3k9 PE=2 SV=1
Length = 1077
Score = 182 bits (461), Expect = 7e-045
Identities = 101/289 (34%), Positives = 162/289 (56%), Gaps = 17/289 (5%)
Frame = +3
Query: 615 IDLRKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLS 794
ID +L + G FGK+YR + G++VA+K R + + +Q +E +QE + +
Sbjct: 132 IDFAELTLEEIIGIGGFGKVYRAFWAGDEVAVK-AARHDPDEDISQTIE-NVRQEAKLFA 189
Query: 795 FLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGM 974
LKHPNI+ G C+K LC+V E+A+GG + + L+ + +P + V A+ +ARGM
Sbjct: 190 MLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS---GKRIPPDILVNWAVQIARGM 246
Query: 975 AYVHER---NFIHRDLKSDNLLI--------SADRSIKIADFGVARIEVQTEGMTPETGT 1121
Y+H+ IHRDLKS N+LI +++ ++I DFG+AR +T M+ GT
Sbjct: 247 NYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILEITDFGLAREWHRTTKMS-AAGT 305
Query: 1122 YRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPG 1301
Y WMAPE+I+ +++ DV+S+G++LWEL+TG +PF+ + + A+ V + +P
Sbjct: 306 YAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPS 365
Query: 1302 DCLPVLGEIMTRCWDADPEVRPCFAEIVNLLEGAETEVMTTVRKARFRC 1448
C ++M CW+ DP RP F I++ L E + K F C
Sbjct: 366 TCPEPFAKLMEDCWNPDPHSRPSFTSILDQLTTIEESGFFEMPKDSFHC 414
>sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 OS=Homo
sapiens GN=MAP3K11 PE=1 SV=1
Length = 847
Score = 180 bits (456), Expect = 3e-044
Identities = 102/284 (35%), Positives = 159/284 (55%), Gaps = 17/284 (5%)
Frame = +3
Query: 624 RKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLK 803
++L + G FGK+YRG+++GE VA+K ++ E + +QE + + L
Sbjct: 115 QELRLEEVIGIGGFGKVYRGSWRGELVAVKAAR--QDPDEDISVTAESVRQEARLFAMLA 172
Query: 804 HPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYV 983
HPNI+ C++ LC+V EYA GG + + L R VP + V A+ +ARGM Y+
Sbjct: 173 HPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALA---GRRVPPHVLVNWAVQIARGMHYL 229
Query: 984 HERNF---IHRDLKSDNLL----ISAD----RSIKIADFGVARIEVQTEGMTPETGTYRW 1130
H IHRDLKS+N+L I +D +++KI DFG+AR +T M+ GTY W
Sbjct: 230 HCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMS-AAGTYAW 288
Query: 1131 MAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPGDCL 1310
MAPE+I+ +++ DV+SFG++LWEL+TG +P++ + + A+ V + +P C
Sbjct: 289 MAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCP 348
Query: 1311 PVLGEIMTRCWDADPEVRPCFAEIVNLLEGAETEVMTTVRKARF 1442
++M CW DP RP FA I+ LE E +V+ + + F
Sbjct: 349 EPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSF 392
>sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase kinase 11 OS=Mus
musculus GN=Map3k11 PE=1 SV=1
Length = 850
Score = 180 bits (455), Expect = 4e-044
Identities = 100/284 (35%), Positives = 157/284 (55%), Gaps = 17/284 (5%)
Frame = +3
Query: 624 RKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLK 803
++L + G FGK+YRG+++GE VA+K ++ E + +QE + + L
Sbjct: 116 QELRLEEVIGIGGFGKVYRGSWRGELVAVKAAR--QDPDEDISVTAESVRQEARLFAMLA 173
Query: 804 HPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYV 983
HPNI+ C++ LC+V EYA GG + + L R VP + V A+ +ARGM Y+
Sbjct: 174 HPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALA---GRRVPPHVLVNWAVQIARGMHYL 230
Query: 984 HERNF---IHRDLKSDNLLI--------SADRSIKIADFGVARIEVQTEGMTPETGTYRW 1130
H IHRDLKS+N+L+ +++KI DFG+AR +T M+ GTY W
Sbjct: 231 HCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMS-AAGTYAW 289
Query: 1131 MAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPGDCL 1310
MAPE+I+ +++ DV+SFG++LWEL+TG +P++ + + A+ V + +P C
Sbjct: 290 MAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCP 349
Query: 1311 PVLGEIMTRCWDADPEVRPCFAEIVNLLEGAETEVMTTVRKARF 1442
++M CW DP RP FA I+ LE E +V+ + + F
Sbjct: 350 EPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSF 393
>sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kinase 11 OS=Rattus
norvegicus GN=Map3k11 PE=2 SV=1
Length = 850
Score = 180 bits (455), Expect = 4e-044
Identities = 100/284 (35%), Positives = 157/284 (55%), Gaps = 17/284 (5%)
Frame = +3
Query: 624 RKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLK 803
++L + G FGK+YRG+++GE VA+K ++ E + +QE + + L
Sbjct: 116 QELRLEEVIGIGGFGKVYRGSWRGELVAVKAAR--QDPDEDISVTAESVRQEARLFAMLA 173
Query: 804 HPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYV 983
HPNI+ C++ LC+V EYA GG + + L R VP + V A+ +ARGM Y+
Sbjct: 174 HPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALA---GRRVPPHVLVNWAVQIARGMHYL 230
Query: 984 HERNF---IHRDLKSDNLLI--------SADRSIKIADFGVARIEVQTEGMTPETGTYRW 1130
H IHRDLKS+N+L+ +++KI DFG+AR +T M+ GTY W
Sbjct: 231 HCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMS-AAGTYAW 289
Query: 1131 MAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPGDCL 1310
MAPE+I+ +++ DV+SFG++LWEL+TG +P++ + + A+ V + +P C
Sbjct: 290 MAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCP 349
Query: 1311 PVLGEIMTRCWDADPEVRPCFAEIVNLLEGAETEVMTTVRKARF 1442
++M CW DP RP FA I+ LE E +V+ + + F
Sbjct: 350 EPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSF 393
>sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kinase MLT OS=Homo
sapiens GN=MLTK PE=1 SV=2
Length = 800
Score = 179 bits (454), Expect = 5e-044
Identities = 99/276 (35%), Positives = 155/276 (56%), Gaps = 27/276 (9%)
Frame = +3
Query: 657 GAFGKLYRGTYKGED--VAIKLLERPENSPEKAQALEQQFQQEVSMLSFLKHPNIVRFIG 830
G+FG +YR + +D VA+K L + ++E +LS L H NI++F G
Sbjct: 25 GSFGSVYRAKWISQDKEVAVKKL--------------LKIEKEAEILSVLSHRNIIQFYG 70
Query: 831 ACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHER---NFI 1001
++P IVTEYA GS+ ++ ++ + + + A DVA+GM Y+H I
Sbjct: 71 VILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVI 130
Query: 1002 HRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDV 1181
HRDLKS N++I+AD +KI DFG +R T M+ GT+ WMAPE+IQ P ++ D
Sbjct: 131 HRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMS-LVGTFPWMAPEVIQSLPVSETCDT 189
Query: 1182 YSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPGDCLPVLGEIMTRCWDADPEV 1361
YS+G+VLWE++T +PF+ + +Q A+ VV + R T+P C E++ +CW+AD +
Sbjct: 190 YSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKK 249
Query: 1362 RPCFAEIVNLLEGAETEVMTTVR-------KARFRC 1448
RP F +I+++LE + + KA +RC
Sbjct: 250 RPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRC 285
>sp|Q95UN8|M3KSL_DROME Mitogen-activated protein kinase kinase kinase
OS=Drosophila melanogaster GN=slpr PE=1 SV=1
Length = 1161
Score = 176 bits (446), Expect = 4e-043
Identities = 102/298 (34%), Positives = 152/298 (51%), Gaps = 19/298 (6%)
Frame = +3
Query: 582 TQGLANYEEWTIDLRKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALE 761
+ + + + I+ +L + G F K++RG Y GE+VAIK+ + + Q +
Sbjct: 126 SSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAH--QTGEDDMQRMR 183
Query: 762 QQFQQEVSMLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLA 941
QE + LKH NI G C+ LC+V EYA+GGS+ + L + +P +
Sbjct: 184 DNVLQEAKLFWALKHENIAALRGVCLNTK-LCLVMEYARGGSLNRILAGK----IPPDVL 238
Query: 942 VKQALDVARGMAYVHER---NFIHRDLKSDNLLI--------SADRSIKIADFGVARIEV 1088
V A+ +ARGM Y+H + IHRDLKS N+LI +++KI DFG+AR
Sbjct: 239 VNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMY 298
Query: 1089 QTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAV 1268
T+ M+ GTY WM PE+I Y++ DV+S+G++LWELITG P++ + A+ V
Sbjct: 299 NTQRMS-AAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGV 357
Query: 1269 VNRGVRPTVPGDCLPVLGEIMTRCWDADPEVRPCFAEIVNLLEGAETEVMTTVRKARF 1442
+ +P C G +M CW DP RP F EI+ LE T + F
Sbjct: 358 AVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESF 415
>sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kinase MLT OS=Mus
musculus GN=Mltk PE=1 SV=1
Length = 802
Score = 174 bits (439), Expect = 3e-042
Identities = 88/231 (38%), Positives = 142/231 (61%), Gaps = 6/231 (2%)
Frame = +3
Query: 735 SPEKAQALEQ--QFQQEVSMLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTK 908
S +K A+++ + ++E +LS L H NI++F G ++P IVTEYA GS+ ++
Sbjct: 37 SQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINS 96
Query: 909 RQNRAVPLKLAVKQALDVARGMAYVHER---NFIHRDLKSDNLLISADRSIKIADFGVAR 1079
++ + ++ + A DVA+GM Y+H IHRDLKS N++I+AD +KI DFG +R
Sbjct: 97 NRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR 156
Query: 1080 IEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAA 1259
T M+ GT+ WMAPE+IQ P ++ D YS+G+VLWE++T +PF+ + +Q A
Sbjct: 157 FHNHTTHMS-LVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVA 215
Query: 1260 FAVVNRGVRPTVPGDCLPVLGEIMTRCWDADPEVRPCFAEIVNLLEGAETE 1412
+ VV + R T+P C E++ +CW+AD + RP F +I+++LE +
Sbjct: 216 WLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSND 266
>sp|Q5UQG7|YR818_MIMIV Putative serine/threonine-protein kinase/receptor R818
OS=Acanthamoeba polyphaga mimivirus GN=MIMI_R818 PE=4 SV=1
Length = 1651
Score = 165 bits (416), Expect = 1e-039
Identities = 85/274 (31%), Positives = 152/274 (55%), Gaps = 14/274 (5%)
Frame = +3
Query: 603 EEWTIDLRKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEV 782
+EW +D +L + G G++++ +KG +VA+K L + + E+ F+QE+
Sbjct: 784 DEWEVDFHELDFMESLGSGGSGEVFKAMWKGTEVAVKKLVNSNITKD----AERNFKQEI 839
Query: 783 SMLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDV 962
++ L+HPN+V F+ A +P +CIV E+ GS+ L +P L ++ A
Sbjct: 840 HRMTSLRHPNVVLFMAASTRPPNMCIVMEFMSLGSLYDLLGNELVTEIPPVLRIRIAYQA 899
Query: 963 ARGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARIEVQTEGMT----PETGTYRW 1130
A+GM ++H + +HRDLKS NLL+ + ++K++DFG+ +I+ +G + + +W
Sbjct: 900 AKGMHFLHSSDIVHRDLKSLNLLLDSKWNVKVSDFGLTKIKDNNKGKSSTKEDSVCSIQW 959
Query: 1131 MAPEMIQHRPYTQKV--DVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPGD 1304
APE++ + + DVYSFGI++WEL+T L P+ ++ A AV+ +RP + +
Sbjct: 960 TAPEVLSEKQDIDYILADVYSFGIIMWELMTRLRPYIGLSPAAIAVAVIRDNLRPEIQEE 1019
Query: 1305 CLPVLG----EIMTRCWDADPEVRPCFAEIVNLL 1394
+ ++ E++ CW D +RP F EI+ L
Sbjct: 1020 DINLMSSDYVELVNICWHKDTMIRPSFLEIMTKL 1053
>sp|Q7T6Y2|YR831_MIMIV Putative serine/threonine-protein kinase/receptor R831
OS=Acanthamoeba polyphaga mimivirus GN=MIMI_R831 PE=4 SV=2
Length = 1624
Score = 163 bits (412), Expect = 3e-039
Identities = 80/240 (33%), Positives = 139/240 (57%), Gaps = 9/240 (3%)
Frame = +3
Query: 606 EWTIDLRKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVS 785
+W ID +L +G G +G++Y+ +KG +VA+KL+ +S ++ +E+ F +EV
Sbjct: 778 DWEIDFSELEIGETLGTGGYGEVYKSIWKGTEVAVKLI----SSKHVSKDMERSFFEEVK 833
Query: 786 MLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVA 965
+++ L+HPN+V F+ A K +CIV E+ GS+ L +P L +K A +
Sbjct: 834 IMTSLRHPNVVLFMAASTKSPNMCIVMEFMSLGSLYDLLGNELIPEIPYALKIKMAYQAS 893
Query: 966 RGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPE---TGTYRWMA 1136
+GM ++H +HRDLKS NLL+ + ++K++DFG+ +++ + + GT W+A
Sbjct: 894 KGMHFLHSSGIVHRDLKSLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIHWIA 953
Query: 1137 PEMIQHRPYTQKV--DVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPGDCL 1310
PE++ + DVYSFGI+LWEL+T P++ MT A +V+ G+RP + + +
Sbjct: 954 PEILNDSTEVDYILADVYSFGIILWELLTREQPYKGMTPAAIAVSVIRDGMRPPISDEAV 1013
>sp|Q54L00|LIMKA_DICDI Probable LIM domain-containing serine/threonine-protein
kinase DDB_G0287001 OS=Dictyostelium discoideum GN=DDB_G0287001 PE=3
SV=1
Length = 650
Score = 162 bits (408), Expect = 1e-038
Identities = 99/279 (35%), Positives = 154/279 (55%), Gaps = 12/279 (4%)
Frame = +3
Query: 570 GSYPTQGLANYEEWTIDLRKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKA 749
G ++ ++ Y+E + ++ G A GA GK+Y+G YKG DVAIK+ S E
Sbjct: 368 GEVLSKKISIYKE--LSKEEVAFGDVIASGASGKVYKGIYKGRDVAIKVY-----SSENF 420
Query: 750 QALEQQFQQEVSMLSFL--KHPNIVRFIGACIK-PMVLCIVTEYAKGGSVRQFLTKRQNR 920
++F +EV+++S + HPN RF GA + L V+E K GS+R L ++ +
Sbjct: 421 CFNIEEFDREVTIMSLIDSDHPNFTRFYGANKQNKKYLFHVSELVKSGSLRDLLLDKE-K 479
Query: 921 AVPLKLAVKQALDVARGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARIEVQTEG 1100
+ + A D+A M ++H IHRDLKS N+LI+ D + K+ DFG +R +
Sbjct: 480 PLAYFTQLSIASDIANAMKHLHSIGVIHRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKQ 539
Query: 1101 MTPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRG 1280
MT GT +M+PE+ + Y + DVY+FGIVLWE+I P++N+ + +V +G
Sbjct: 540 MTLNLGTSCYMSPELFKGNGYDETCDVYAFGIVLWEIIARKEPYENINSWSIP-VLVAKG 598
Query: 1281 VRPTVPGDCLPVLGEIMTRCWDADPEVRPCFAEIVNLLE 1397
RPT+P DC +++ CW P+ RP F EI + L+
Sbjct: 599 ERPTIPADCPSEYSKLIKACWTDKPKKRPSFKEICDTLK 637
>sp|Q54I36|PYK3_DICDI Dual specificity protein kinase pyk3 OS=Dictyostelium
discoideum GN=pyk3 PE=1 SV=1
Length = 1338
Score = 161 bits (405), Expect = 2e-038
Identities = 86/216 (39%), Positives = 130/216 (60%), Gaps = 10/216 (4%)
Frame = +3
Query: 759 EQQFQQEVSMLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKL 938
+++F +EVS L HPN+V F+GACI P CI TEY +GGS+ L ++ + PL +
Sbjct: 1094 DEKFIKEVSSLIKSHHPNVVTFMGACIDPP--CIFTEYLQGGSLYDVLHIQKIKLNPL-M 1150
Query: 939 AVKQALDVARGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARI---EVQTEGMTP 1109
K D++ GM ++H +HRDL S N+L+ ++IKIADFG+A ++ G+T
Sbjct: 1151 MYKMIHDLSLGMEHLHSIQMLHRDLTSKNILLDEFKNIKIADFGLATTLSDDMTLSGIT- 1209
Query: 1110 ETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRP 1289
RW +PE+ + Y +KVDVYSFG+V++E+ TG +PF+ + +A RP
Sbjct: 1210 ---NPRWRSPELTKGLVYNEKVDVYSFGLVVYEIYTGKIPFEGLDGTASAAKAAFENYRP 1266
Query: 1290 TVPGDCLPVLGEIMTRCWDADPEVRPCFAEIVNLLE 1397
+P DC L +++T+CW +DP RP F EI+ LE
Sbjct: 1267 AIPPDCPVSLRKLITKCWASDPSQRPSFTEILTELE 1302
>sp|P0CD62|LIMKB_DICDI Probable LIM domain-containing serine/threonine-protein
kinase DDB_G0286997 OS=Dictyostelium discoideum GN=DDB_G0286997 PE=3
SV=1
Length = 966
Score = 159 bits (401), Expect = 7e-038
Identities = 96/256 (37%), Positives = 142/256 (55%), Gaps = 10/256 (3%)
Frame = +3
Query: 639 GPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFL--KHPN 812
G A GA GK+Y+G YKG DVAIK+ S E +F +EV+++S + HPN
Sbjct: 705 GDVIAAGASGKVYKGIYKGRDVAIKVY-----SSENFCFNIDEFDREVTIMSLIDSDHPN 759
Query: 813 IVRFIGACIK-PMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHE 989
RF GA + L V+E K GS+R L ++ + + + A D+A M ++H
Sbjct: 760 FTRFYGANKQNKKYLFHVSELVKSGSLRDLLLDKE-KPLLYFTQLSIASDIANAMKHLHS 818
Query: 990 RNFIHRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQ 1169
IHRDLKS N+LI+ D + K+ DFG +R + MT GT +M+PE+ + Y +
Sbjct: 819 IGVIHRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKHMTMNLGTSCYMSPELFKGNGYDE 878
Query: 1170 KVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPGDCLPVLGEIMTRCWDA 1349
DVY+FGIVLWE+I P++N+ + +V +G RPT+P DC +++ CW
Sbjct: 879 TCDVYAFGIVLWEIIARKEPYENINSWSIP-VMVAKGDRPTIPADCPSEYSKLIKACWTD 937
Query: 1350 DPEVRPCFAEIVNLLE 1397
P+ RP F EI + L+
Sbjct: 938 KPKKRPSFKEICDTLK 953
>sp|Q54TA1|DRKC_DICDI Probable serine/threonine-protein kinase drkC
OS=Dictyostelium discoideum GN=drkC PE=3 SV=1
Length = 749
Score = 156 bits (392), Expect = 7e-037
Identities = 88/218 (40%), Positives = 127/218 (58%), Gaps = 10/218 (4%)
Frame = +3
Query: 765 QFQQEVSMLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAV 944
+ QE +++S L+HPNI +F+G C P + IV EY GS+ + L + ++
Sbjct: 533 ELAQEATIMSQLRHPNICQFLGTCNNPPEILIVMEYMPLGSLYRIL-HDPSISLDWPRMK 591
Query: 945 KQALDVARGMAYVH--ERNFIHRDLKSDNLLISADRSIKIADFGVA-----RIEVQTEGM 1103
ALD+A+GM Y+H + IHRDLKS NLL+ +KI+DFG++ ++ +T M
Sbjct: 592 SMALDIAKGMNYLHCCDPIVIHRDLKSHNLLVDEHYRVKISDFGLSTRFKKHLDKKT-AM 650
Query: 1104 TPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGV 1283
TP GT W APE++++ PYT+K DV+SF IVLWE++T P+Q M Q +V +
Sbjct: 651 TP-VGTPCWTAPEVLRNDPYTEKADVFSFAIVLWEIVTREDPYQGMPTFQIVISVGQHKL 709
Query: 1284 RPTVPGDCLPVLGEIMTRCWDADPEVRPCFAEIVNLLE 1397
RP VP ++T CW DP+ RP F EIV LE
Sbjct: 710 RPIVPPQVSAPFTRLITECWSEDPQQRPSFQEIVKRLE 747
>sp|Q54RZ7|Y1199_DICDI Probable serine/threonine-protein kinase DDB_G0282895
OS=Dictyostelium discoideum GN=DDB_G0282895 PE=3 SV=1
Length = 1634
Score = 153 bits (385), Expect = 5e-036
Identities = 86/265 (32%), Positives = 151/265 (56%), Gaps = 12/265 (4%)
Frame = +3
Query: 615 IDLRKLHMGPAFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLS 794
I+ +L + +GA ++++G +KG++VA+K+ N + LE F +EV++L
Sbjct: 1372 IEESELQILQFLGEGALAEVHKGIWKGKEVAVKIF----NEGSFSFRLE-DFLKEVAILG 1426
Query: 795 FLKHPNIVRFIGACIKP----MVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDV 962
+ HPN+++ GACI P IVTE G++ + + K N+ + L+ +K AL V
Sbjct: 1427 LISHPNLLKLKGACIAPRSHKSTFMIVTELMHKGTLLEVINK--NKPLSLEDIIKYALSV 1484
Query: 963 ARGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPE 1142
A+G+AY+H +FIHRD+K+ N+L+ + + K+ DFG++R+ MT GT +W +PE
Sbjct: 1485 AQGLAYLHSVDFIHRDIKAANILVDKNNNAKVGDFGLSRVIDNNFNMTAVAGTPKWESPE 1544
Query: 1143 MIQHRPYTQKVDVYSFGIVLWELITGLLPF-QNMTAVQAAFAVVNRGVRPTVPGDCLPVL 1319
+ YT DVYS+G++L+EL TG PF + + V+ A +V ++ ++P + +
Sbjct: 1545 CLMGEAYTSASDVYSYGMMLFELATGDEPFLEIQSIVELARSVCDKKLKPKISSSVPNFI 1604
Query: 1320 GEIMTRCWDADPEVRPCFAEIVNLL 1394
++ C P+ RP +I+ L
Sbjct: 1605 SSLIKDCLHNSPKKRPTMNQIIQKL 1629
>sp|P00522|ABL_DROME Tyrosine-protein kinase Abl OS=Drosophila melanogaster
GN=Abl PE=1 SV=3
Length = 1620
Score = 150 bits (377), Expect = 4e-035
Identities = 85/271 (31%), Positives = 145/271 (53%), Gaps = 15/271 (5%)
Frame = +3
Query: 603 EEWTIDLRKLHMGPAFAQGAFGKLYRGTYK--GEDVAIKLLERPENSPEKAQALEQQFQQ 776
+EW I + M G +G++Y +K G VA+K L+ E AL + F +
Sbjct: 362 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLK------EDTMAL-KDFLE 414
Query: 777 EVSMLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQAL 956
E +++ +KHPN+V+ IG C + I+TE+ G++ FL + + A
Sbjct: 415 EAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMAT 474
Query: 957 DVARGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGT---YR 1127
+A GM+Y+ RN+IHRDL + N L+ ++ +K+ADFG+AR+ ++ + T G +
Sbjct: 475 QIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARL-MRDDTYTAHAGAKFPIK 533
Query: 1128 WMAPEMIQHRPYTQKVDVYSFGIVLWELIT-GLLPFQNMTAVQAAFAVVNRGVRPTVPGD 1304
W APE + + ++ K DV++FG++LWE+ T G+ P+ + + +++G R P
Sbjct: 534 WTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTD-VYHKLDKGYRMERPPG 592
Query: 1305 CLPVLGEIMTRCWDADPEVRPCFAEIVNLLE 1397
C P + ++M +CW D RP F I + LE
Sbjct: 593 CPPEVYDLMRQCWQWDATDRPTFKSIHHALE 623
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,414,502,248
Number of Sequences: 518415
Number of Extensions: 42414502248
Number of Successful Extensions: 312188416
Number of sequences better than 0.0: 0
|
