BLASTX 7.6.2
Query= UN10706 /QuerySize=1621
(1620 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P53780|METC_ARATH Cystathionine beta-lyase, chloroplastic OS=... 833 1e-240
sp|O94350|CBL_SCHPO Cystathionine beta-lyase OS=Schizosaccharomy... 356 3e-097
sp|O31632|METC_BACSU Cystathionine beta-lyase metC OS=Bacillus s... 343 3e-093
sp|O05394|MCCB_BACSU Cystathionine gamma-lyase OS=Bacillus subti... 342 4e-093
sp|Q55DV9|CGL_DICDI Cystathionine gamma-lyase OS=Dictyostelium d... 334 1e-090
sp|P0A4K2|METC_LACLA Cystathionine beta-lyase OS=Lactococcus lac... 327 2e-088
sp|A2RM21|METC_LACLM Cystathionine beta-lyase OS=Lactococcus lac... 327 2e-088
sp|P56069|METB_HELPY Cystathionine gamma-synthase OS=Helicobacte... 322 6e-087
sp|P0C2T9|METC_LACLC Cystathionine beta-lyase OS=Lactococcus lac... 322 8e-087
sp|Q9ZMW7|METB_HELPJ Cystathionine gamma-synthase OS=Helicobacte... 317 1e-085
sp|Q8VCN5|CGL_MOUSE Cystathionine gamma-lyase OS=Mus musculus GN... 315 7e-085
sp|P32929|CGL_HUMAN Cystathionine gamma-lyase OS=Homo sapiens GN... 310 2e-083
sp|Q58DW2|CGL_BOVIN Cystathionine gamma-lyase OS=Bos taurus GN=C... 310 3e-083
sp|Q60HG7|CGL_MACFA Cystathionine gamma-lyase OS=Macaca fascicul... 308 1e-082
sp|Q19QT7|CGL_PIG Cystathionine gamma-lyase OS=Sus scrofa GN=CTH... 307 1e-082
sp|P18757|CGL_RAT Cystathionine gamma-lyase OS=Rattus norvegicus... 305 7e-082
sp|P66876|METB_MYCBO Cystathionine gamma-synthase OS=Mycobacteri... 290 3e-077
sp|P66875|METB_MYCTU Cystathionine gamma-synthase OS=Mycobacteri... 290 3e-077
sp|P46807|METB_MYCLE Cystathionine gamma-synthase OS=Mycobacteri... 280 2e-074
sp|P00935|METB_ECOLI Cystathionine gamma-synthase OS=Escherichia... 265 8e-070
>sp|P53780|METC_ARATH Cystathionine beta-lyase, chloroplastic OS=Arabidopsis
thaliana GN=At3g57050 PE=1 SV=1
Length = 464
Score = 833 bits (2150), Expect = 1e-240
Identities = 416/464 (89%), Positives = 447/464 (96%), Gaps = 3/464 (0%)
Frame = +3
Query: 72 SLSLHSSFVPSFSDLHDRGLVSKNSPTTVSITKFPTWEKKKKKQISNRNLFKLSCVMEKS 251
SLSLHSSFVPSF+DL DRGL+SKNSPT+VSI+K PTWE KKQISNRN FKL+CVMEKS
Sbjct: 4 SLSLHSSFVPSFADLSDRGLISKNSPTSVSISKVPTWE---KKQISNRNSFKLNCVMEKS 60
Query: 252 IDGNSHSVVNTTQDCLNDVNVREEASVATLLMNLDNKFDPFDAMSTPLYQTATFKQPSAI 431
+DG +HS VN T D LN +N++EEASV+TLL+NLDNKFDPFDAMSTPLYQTATFKQPSAI
Sbjct: 61 VDGQTHSTVNNTTDSLNTMNIKEEASVSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAI 120
Query: 432 ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALAAVTHLLKSGDELVAGDDL 611
ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL+AVTHL+K+G+E+VAGDD+
Sbjct: 121 ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDV 180
Query: 612 YGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVWLESPTNPRQQISDIRKIA 791
YGGSDRLLS VVPRSGVVVKRVNTT L+EVAAAI P+TKLVWLESPTNPRQQISDIRKI+
Sbjct: 181 YGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIS 240
Query: 792 EMAHAQGALLLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDLMAGVLSVKGEQLAK 971
EMAHAQGAL+LVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSD+MAGVL+VKGE+LAK
Sbjct: 241 EMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAK 300
Query: 972 ELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSTHPRVKQVYYAGL 1151
E+YFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLS+HPRVK+VYYAGL
Sbjct: 301 EVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGL 360
Query: 1152 PDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMS 1331
PDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMS
Sbjct: 361 PDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMS 420
Query: 1332 HASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLAFRTGPI 1463
HASIPAEVREARGLTEDLVRISAGIED DDLISDLD+AF+T P+
Sbjct: 421 HASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKTFPL 464
>sp|O94350|CBL_SCHPO Cystathionine beta-lyase OS=Schizosaccharomyces pombe
GN=str3 PE=2 SV=4
Length = 390
Score = 356 bits (913), Expect = 3e-097
Identities = 194/376 (51%), Positives = 261/376 (69%), Gaps = 5/376 (1%)
Frame = +3
Query: 327 SVATLLMNLDNKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKL 506
SV T L++++ D + A S P+YQ+ATFKQP G +DYTRSGNPTR L+ LAKL
Sbjct: 8 SVDTELVHVEGNEDQYHASSVPIYQSATFKQPCLEHMGKFDYTRSGNPTRSVLQVHLAKL 67
Query: 507 DKADRAFCFTSGMAALAAVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTT 686
KA AF ++GM+AL + KS +VAG DLYGGSDRLLS + G V V+T+
Sbjct: 68 MKAKHAFVTSNGMSALDMILRCCKSNSHVVAGHDLYGGSDRLLSFNQRQYGFKVDNVDTS 127
Query: 687 SLEEVAAAISPRTKLVWLESPTNPRQQISDIRKIAEM--AHAQGALLLVDNSIMSPVLSR 860
L AA+ P T LV +ESPTNPR I DIR I ++ + A+ ALL++DN+++SPVL
Sbjct: 128 DLAAFEAALRPDTNLVLIESPTNPRISICDIRAIVKITRSKAKDALLVMDNTMLSPVLCN 187
Query: 861 PLELGADIVMHSATKFIAGHSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLR 1040
PL+ G DIV SATK+++GH DLM GV++ K +++AK ++F N+ G+ +APF+C+L LR
Sbjct: 188 PLDFGYDIVYESATKYLSGHHDLMGGVIATKSDEIAKSVFFNINAMGAAMAPFECFLLLR 247
Query: 1041 GIKTMALRIEKQQENARKIAMYLSTHPRVKQVYYAGL-PDHPGHHLHFSQAKGAGSVFSF 1217
GIKTM LR+E+ Q+NA +IA +L + + QV + GL PD + +S A+G G+V S
Sbjct: 248 GIKTMGLRVERAQQNAIEIAKFLKS--KGLQVNFPGLDPDAKSTAIFYSFARGPGAVMSV 305
Query: 1218 ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRIS 1397
TG V +SK +V TTK F I+VSFG+V SLISMP +MSHASI EVR+ARGL+EDL+RI
Sbjct: 306 FTGDVEVSKTIVNTTKLFEISVSFGAVNSLISMPAYMSHASIKKEVRDARGLSEDLIRIC 365
Query: 1398 AGIEDADDLISDLDLA 1445
GIE+ DDL +DL+ A
Sbjct: 366 VGIENVDDLKADLENA 381
>sp|O31632|METC_BACSU Cystathionine beta-lyase metC OS=Bacillus subtilis GN=metC
PE=1 SV=1
Length = 390
Score = 343 bits (878), Expect = 3e-093
Identities = 169/358 (47%), Positives = 242/358 (67%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALA 557
A+S P+ +TF Q S E G YDY+RSG PTR ALE +A L+ R F F+SGMAA++
Sbjct: 25 AVSVPIQHASTFHQSSFEEFGAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAIS 84
Query: 558 AVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVW 737
LL GD ++ +D+YGG+ R+++ V+ R G+ V+ T EVA +I P TK+++
Sbjct: 85 TAFLLLSQGDHVLVTEDVYGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIY 144
Query: 738 LESPTNPRQQISDIRKIAEMAHAQGALLLVDNSIMSPVLSRPLELGADIVMHSATKFIAG 917
+E+P+NP I+DI+ + ++A G L +DN+ M+P L RPL+LG DIV+HSATKF++G
Sbjct: 145 METPSNPTLGITDIKAVVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSG 204
Query: 918 HSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 1097
HSD+++G+ +VK E+L K+LY LQN+ G+ L DCWL LRG+KT+ +R+EK + A+++
Sbjct: 205 HSDVLSGLAAVKDEELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRL 264
Query: 1098 AMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSI 1277
A + HP VK+VYY GL DHPG H SQ+ GAG+V SF S K LVE
Sbjct: 265 AEFFQKHPAVKRVYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVF 324
Query: 1278 AVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLAFR 1451
AVS G+V+S++S P MSHA++P E RE RG+T+ L+R+S G+E ADDL D + A +
Sbjct: 325 AVSLGAVESILSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALK 382
>sp|O05394|MCCB_BACSU Cystathionine gamma-lyase OS=Bacillus subtilis GN=mccB
PE=1 SV=1
Length = 379
Score = 342 bits (877), Expect = 4e-093
Identities = 170/356 (47%), Positives = 245/356 (68%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALA 557
A+S P+YQ +T+KQP A ++ Y+Y+R+ NPTR ALE+L+ +L+ + + F+SGMAA+
Sbjct: 20 AVSVPIYQVSTYKQPKAGQHTGYEYSRTANPTRTALEALVTELESGEAGYAFSSGMAAIT 79
Query: 558 AVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVW 737
AV L SGD +V DD+YGG+ R+++ V+ R G+ V+T+S EEV AI P TK ++
Sbjct: 80 AVMMLFNSGDHVVLTDDVYGGTYRVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIY 139
Query: 738 LESPTNPRQQISDIRKIAEMAHAQGALLLVDNSIMSPVLSRPLELGADIVMHSATKFIAG 917
+E+PTNP +I+D+ +A++A G LL+VDN+ +P +PL LGADIV+HSATK++ G
Sbjct: 140 IETPTNPLLKITDLTLMADIAKKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGG 199
Query: 918 HSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 1097
HSD++ G++ ++L +EL+F+QNS G L P D WL +RGIKT+ LR+E +NARKI
Sbjct: 200 HSDVVGGLVVTASKELGEELHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKI 259
Query: 1098 AMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSI 1277
A +L HP V+ +YY G +HPGH L +Q G G + SF GS + K F+I
Sbjct: 260 ASFLENHPAVQTLYYPGSSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTI 319
Query: 1278 AVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLA 1445
A S G+V+SLIS+P M+HASIP E R G+T+ L+RIS GIEDA+DL+ D+ A
Sbjct: 320 AESLGAVESLISVPARMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQA 375
>sp|Q55DV9|CGL_DICDI Cystathionine gamma-lyase OS=Dictyostelium discoideum
GN=cysA PE=1 SV=1
Length = 387
Score = 334 bits (855), Expect = 1e-090
Identities = 165/358 (46%), Positives = 242/358 (67%), Gaps = 2/358 (0%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPS-AIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL 554
A+ P+ + TF QPS + + YDY+RSGNPTR A E +A + A A F SG+A L
Sbjct: 26 AVIVPISLSTTFLQPSPGVLHSEYDYSRSGNPTRKAFEECIAACENAKYALSFASGLATL 85
Query: 555 AAVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLV 734
+THLLKSGDE+++ DD+YGG+ R + V + V+ ++L+++ A + +T+LV
Sbjct: 86 TTITHLLKSGDEVISIDDVYGGTRRYFTRVAANFDLKFSFVDLSTLDDLKNAFTDKTRLV 145
Query: 735 WLESPTNPRQQISDIRKIAEMAHAQGALLLVDNSIMSPVLSRPLELGADIVMHSATKFIA 914
W+E+PTNP +++DI+ +A+ H++GA L+VDN+ MSP PL+LGADIVMHS TK+I
Sbjct: 146 WIETPTNPLLKVADIKAVADYVHSRGATLVVDNTFMSPYFQNPLDLGADIVMHSVTKYIN 205
Query: 915 GHSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 1094
GHSD + GVL+ ++L +L FLQNS G+ +PFDC+L LRG+KT+ +R+E Q+NA
Sbjct: 206 GHSDCVMGVLATNNDELYAKLKFLQNSIGAVPSPFDCFLALRGLKTLHVRMEAHQKNAFA 265
Query: 1095 IAMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKG-AGSVFSFITGSVALSKHLVETTKYF 1271
I +L HP+V++V Y GLP HP H + Q KG G V F+ GS+ S+ +E K F
Sbjct: 266 ICNFLEKHPKVERVIYPGLPSHPQHEICKRQMKGYGGMVVFFVKGSIDQSRSFLENIKLF 325
Query: 1272 SIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLA 1445
++A S G V+SLI +P M+HAS+PAE R G+++ L+R+S GIED +DL++D+ A
Sbjct: 326 ALAESLGGVESLIELPSVMTHASVPAEERAKLGISDTLIRLSVGIEDINDLLADISQA 383
>sp|P0A4K2|METC_LACLA Cystathionine beta-lyase OS=Lactococcus lactis subsp.
lactis GN=metC PE=3 SV=1
Length = 380
Score = 327 bits (836), Expect = 2e-088
Identities = 159/353 (45%), Positives = 237/353 (67%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALA 557
A+S P+YQT+T+KQ + Y+Y+RSGNPTR ALE L+A L+ + F F+SG+A +
Sbjct: 21 AVSVPIYQTSTYKQNGLGQPKEYEYSRSGNPTRHALEELIADLEGGVQGFAFSSGLAGIH 80
Query: 558 AVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVW 737
AV L +GD ++ DD+YGG+ RL+ V+ ++G++ V+ ++L+++ AA TK ++
Sbjct: 81 AVLSLFSAGDHIILADDVYGGTFRLMDKVLTKTGIIYDLVDLSNLDDLKAAFKEETKAIY 140
Query: 738 LESPTNPRQQISDIRKIAEMAHAQGALLLVDNSIMSPVLSRPLELGADIVMHSATKFIAG 917
E+P+NP ++ DI++I+ +A A AL LVDN+ +P L +P+ LGADIV+HSATK++ G
Sbjct: 141 FETPSNPLLKVLDIKEISAIAKAHDALTLVDNTFATPYLQQPIALGADIVLHSATKYLGG 200
Query: 918 HSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 1097
HSD++AG+++ ++LA E+ FLQNS G+ L P D WL RGIKT+ALR+E NA+KI
Sbjct: 201 HSDVVAGLVTTNSKELASEIGFLQNSIGAVLGPQDSWLVQRGIKTLALRMEAHSANAQKI 260
Query: 1098 AMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSI 1277
A +L T V +VYY GL HPGH + Q G + SF K VE YF++
Sbjct: 261 AEFLETSKAVSKVYYPGLNSHPGHEIAKKQMSAFGGMISFELTDENAVKDFVENLSYFTL 320
Query: 1278 AVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDL 1436
A S G V+SLI +P M+HASIP E+RE G+ + L+R+S G+E +DL++D+
Sbjct: 321 AESLGGVESLIEVPAVMTHASIPKELREEIGIKDGLIRLSVGVEAIEDLLTDI 373
>sp|A2RM21|METC_LACLM Cystathionine beta-lyase OS=Lactococcus lactis subsp.
cremoris (strain MG1363) GN=metC PE=1 SV=1
Length = 380
Score = 327 bits (836), Expect = 2e-088
Identities = 159/353 (45%), Positives = 237/353 (67%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALA 557
A+S P+YQT+T+KQ + Y+Y+RSGNPTR ALE L+A L+ + F F+SG+A +
Sbjct: 21 AVSVPIYQTSTYKQNGLGQPKEYEYSRSGNPTRHALEELIADLEGGVQGFAFSSGLAGIH 80
Query: 558 AVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVW 737
AV L +GD ++ DD+YGG+ RL+ V+ ++G++ V+ ++L+++ AA TK ++
Sbjct: 81 AVLSLFSAGDHIILADDVYGGTFRLMDKVLTKTGIIYDLVDLSNLDDLKAAFKEETKAIY 140
Query: 738 LESPTNPRQQISDIRKIAEMAHAQGALLLVDNSIMSPVLSRPLELGADIVMHSATKFIAG 917
E+P+NP ++ DI++I+ +A A AL LVDN+ +P L +P+ LGADIV+HSATK++ G
Sbjct: 141 FETPSNPLLKVLDIKEISAIAKAHDALTLVDNTFATPYLQQPIALGADIVLHSATKYLGG 200
Query: 918 HSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 1097
HSD++AG+++ ++LA E+ FLQNS G+ L P D WL RGIKT+ALR+E NA+KI
Sbjct: 201 HSDVVAGLVTTNSKELASEIGFLQNSIGAVLGPQDSWLVQRGIKTLALRMEAHSANAQKI 260
Query: 1098 AMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSI 1277
A +L T V +VYY GL HPGH + Q G + SF K VE YF++
Sbjct: 261 AEFLETSKAVSKVYYPGLNSHPGHEIAKKQMSAFGGMISFELTDENAVKDFVENLSYFTL 320
Query: 1278 AVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDL 1436
A S G V+SLI +P M+HASIP E+RE G+ + L+R+S G+E +DL++D+
Sbjct: 321 AESLGGVESLIEVPAVMTHASIPKELREEIGIKDGLIRLSVGVEAIEDLLTDI 373
>sp|P56069|METB_HELPY Cystathionine gamma-synthase OS=Helicobacter pylori
GN=metB PE=3 SV=1
Length = 380
Score = 322 bits (824), Expect = 6e-087
Identities = 159/357 (44%), Positives = 236/357 (66%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALA 557
A+S P+YQT+T++Q + + Y+Y+RSGNPTR ALE L+A L+ + F F SG+A +
Sbjct: 20 AVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIH 79
Query: 558 AVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVW 737
AV LL+SGD ++ GDD+YGG+ RL + V+ ++G+ ++T+ + ++ AI P TK ++
Sbjct: 80 AVFSLLQSGDHVLLGDDVYGGTFRLFNQVLVKNGLSCTIIDTSDISQIKKAIKPNTKALY 139
Query: 738 LESPTNPRQQISDIRKIAEMAHAQGALLLVDNSIMSPVLSRPLELGADIVMHSATKFIAG 917
LE+P+NP +I+D+ + A +A G L +VDN+ +P PL LGADIV HS TK++ G
Sbjct: 140 LETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVAHSGTKYLGG 199
Query: 918 HSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 1097
HSD++AG+++ E LA+E+ F QN+ G L P D WL RGIKT+ LR+E Q+NA +
Sbjct: 200 HSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCV 259
Query: 1098 AMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSI 1277
A +L HP+V++VYY GLP HP + L Q +G + SF + + + VE+ K F +
Sbjct: 260 AEFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFTLKNDSEAVAFVESLKLFIL 319
Query: 1278 AVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLAF 1448
S G V+SL+ +P FM+HA IP REA G+ + LVR+S GIE DL+ DL+ AF
Sbjct: 320 GESLGGVESLVGIPAFMTHACIPKTQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAF 376
>sp|P0C2T9|METC_LACLC Cystathionine beta-lyase OS=Lactococcus lactis subsp.
cremoris GN=metC PE=1 SV=1
Length = 380
Score = 322 bits (823), Expect = 8e-087
Identities = 159/353 (45%), Positives = 236/353 (66%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALA 557
A+S P+YQT+T+KQ + Y+Y+RSGNPTR ALE L+A L+ + F F+SG+A +
Sbjct: 21 AVSVPIYQTSTYKQNGLGQPKEYEYSRSGNPTRHALEELIADLEGGVQGFAFSSGLAGIH 80
Query: 558 AVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVW 737
AV L +GD ++ DD+YGG+ RL+ V+ ++G++ V+ ++LE++ AA TK V+
Sbjct: 81 AVLSLFSAGDHIILADDVYGGTFRLVDKVLTKTGIIYDLVDLSNLEDLKAAFKAETKAVY 140
Query: 738 LESPTNPRQQISDIRKIAEMAHAQGALLLVDNSIMSPVLSRPLELGADIVMHSATKFIAG 917
E+P+NP ++ DI++I+ +A A AL LVDN+ +P L +P+ LGADIV+HSATK++ G
Sbjct: 141 FETPSNPLLKVLDIKEISSIAKAHNALTLVDNTFATPYLQQPIALGADIVLHSATKYLGG 200
Query: 918 HSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 1097
HSD++AG+++ +LA E+ FLQNS G+ L P D WL RGIKT+A R+E NA+KI
Sbjct: 201 HSDVVAGLVTTNSNELAIEIGFLQNSIGAVLGPQDSWLVQRGIKTLAPRMEAHSANAQKI 260
Query: 1098 AMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSI 1277
A +L V +VYY GL +H GH + Q G + SF K+ VE +YF++
Sbjct: 261 AEFLEASQAVSKVYYPGLVNHEGHEIAKKQMTAFGGMISFELTDENAVKNFVENLRYFTL 320
Query: 1278 AVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDL 1436
A S G V+SLI +P M+HASIP E+RE G+ + L+R+S G+E +DL++DL
Sbjct: 321 AESLGGVESLIEVPAVMTHASIPKELREEIGIKDGLIRLSVGVEALEDLLTDL 373
>sp|Q9ZMW7|METB_HELPJ Cystathionine gamma-synthase OS=Helicobacter pylori J99
GN=metB PE=3 SV=1
Length = 380
Score = 317 bits (812), Expect = 1e-085
Identities = 158/357 (44%), Positives = 233/357 (65%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALA 557
A+S P+YQT+T++Q + + Y+Y+RSGNPTR ALE L+A L+ + F F SG+A +
Sbjct: 20 AVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIH 79
Query: 558 AVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVW 737
AV LL+SGD ++ GDD+YGG+ RL + V+ ++G+ ++T+ L ++ AI P TK ++
Sbjct: 80 AVFSLLQSGDHVLLGDDVYGGNFRLFNKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALY 139
Query: 738 LESPTNPRQQISDIRKIAEMAHAQGALLLVDNSIMSPVLSRPLELGADIVMHSATKFIAG 917
LE+P+NP +I+D+ + A +A L +VDN+ +P PL LG DIV H+ TK++ G
Sbjct: 140 LETPSNPLLKITDLAQCASVAKEHNLLTIVDNTFATPYCQNPLLLGTDIVAHNGTKYLGG 199
Query: 918 HSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 1097
HSD++AG+++ E LA+E F QN+ G L D WL RGIKT+ LR+E Q+NA +
Sbjct: 200 HSDVVAGLVTTNNEALAQEFDFFQNAIGGVLGLQDSWLLQRGIKTLGLRMEAHQKNALCV 259
Query: 1098 AMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSI 1277
A +L HP+V++VYY GLP HP H L +Q +G +FSF + + + VE+ K F +
Sbjct: 260 AEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMFSFTLKNDSEAVAFVESLKLFIL 319
Query: 1278 AVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLAF 1448
S G V+SL+ +P M+HA IP REA G+ + LVR+S GIE DL+ DLD AF
Sbjct: 320 GESLGGVESLVGIPALMTHACIPKAQREAAGIRDGLVRLSVGIEHEQDLLEDLDQAF 376
>sp|Q8VCN5|CGL_MOUSE Cystathionine gamma-lyase OS=Mus musculus GN=Cth PE=1 SV=1
Length = 398
Score = 315 bits (806), Expect = 7e-085
Identities = 157/360 (43%), Positives = 235/360 (65%), Gaps = 2/360 (0%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALA 557
A+ P+ TFKQ ++ ++Y+RSGNPTR+ LE +A LD A + F SG+AA
Sbjct: 35 AVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAATI 94
Query: 558 AVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVW 737
+THLLK+GDE++ D++YGG++R V G+ + V+ + + + AAI+P+TKLVW
Sbjct: 95 TITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVW 154
Query: 738 LESPTNPRQQISDIRKIAEMAHAQG-ALLLVDNSIMSPVLSRPLELGADIVMHSATKFIA 914
+E+PTNP +++DI A++ H +G +L+VDN+ MS RPL LGADI M SATK++
Sbjct: 155 IETPTNPTLKLADIGACAQIVHKRGDIILVVDNTFMSAYFQRPLALGADICMCSATKYMN 214
Query: 915 GHSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 1094
GHSD++ G++SV + L L FLQNS G+ +PFDC+LC RG+KT+ +R+EK +N
Sbjct: 215 GHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMA 274
Query: 1095 IAMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGA-GSVFSFITGSVALSKHLVETTKYF 1271
+A +L T+PRV++V Y GLP HP H L Q G G V +I G++ +K ++ K F
Sbjct: 275 VARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLF 334
Query: 1272 SIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLAFR 1451
++A S G +SL +P M+HAS+P + R G+ + L+R+S G+ED DL+ DLD A +
Sbjct: 335 TLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALK 394
>sp|P32929|CGL_HUMAN Cystathionine gamma-lyase OS=Homo sapiens GN=CTH PE=1 SV=3
Length = 405
Score = 310 bits (793), Expect = 2e-083
Identities = 155/360 (43%), Positives = 235/360 (65%), Gaps = 2/360 (0%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALA 557
A+ P+ + TFKQ + ++ ++Y+RSGNPTR+ LE +A LD A F SG+AA
Sbjct: 36 AVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATV 95
Query: 558 AVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVW 737
+THLLK+GD+++ DD+YGG++R V G+ + V+ + ++ + AAI+P TKLVW
Sbjct: 96 TITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVW 155
Query: 738 LESPTNPRQQISDIRKIAEMAHAQG-ALLLVDNSIMSPVLSRPLELGADIVMHSATKFIA 914
+E+PTNP Q++ DI A + H G +L+VDN+ MSP RPL LGADI M+SATK++
Sbjct: 156 IETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMN 215
Query: 915 GHSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 1094
GHSD++ G++SV E L L FLQNS G+ +P DC+LC RG+KT+ +R+EK +N
Sbjct: 216 GHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMA 275
Query: 1095 IAMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKG-AGSVFSFITGSVALSKHLVETTKYF 1271
+A +L ++P V++V Y GLP HP H L Q G G V +I G++ ++ ++ K F
Sbjct: 276 VAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLF 335
Query: 1272 SIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLAFR 1451
++A S G +SL +P M+HAS+ R+ G+++ L+R+S G+ED +DL+ DLD A +
Sbjct: 336 TLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALK 395
>sp|Q58DW2|CGL_BOVIN Cystathionine gamma-lyase OS=Bos taurus GN=CTH PE=2 SV=1
Length = 405
Score = 310 bits (792), Expect = 3e-083
Identities = 155/360 (43%), Positives = 233/360 (64%), Gaps = 2/360 (0%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALA 557
A+ P+ + TFKQ + ++ ++Y+RSGNPTR+ LE +A LD A + F SG+AA
Sbjct: 36 AVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYSLAFASGLAATV 95
Query: 558 AVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVW 737
+THLLK+GD+++ DD+YGG++R V G+ + V+ + + + AAI+P TKLVW
Sbjct: 96 TITHLLKAGDQIICMDDVYGGTNRYFRQVATEFGLKISFVDCSKPKLLEAAITPETKLVW 155
Query: 738 LESPTNPRQQISDIRKIAEMAHAQG-ALLLVDNSIMSPVLSRPLELGADIVMHSATKFIA 914
+E+PTNP ++ DI A H G +L+VDN+ MS RPL LGADI M+SATK++
Sbjct: 156 IETPTNPSLKMIDIEACAHTVHKHGDIILVVDNTFMSAYFQRPLSLGADICMYSATKYMN 215
Query: 915 GHSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 1094
G+SD++ G++S+ E L L FLQNS G+ +P DC+LC RG+KT+ +R+EK EN
Sbjct: 216 GYSDVVMGLVSLNSESLHDRLRFLQNSLGAVPSPIDCYLCNRGLKTLQVRMEKHFENGMA 275
Query: 1095 IAMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGA-GSVFSFITGSVALSKHLVETTKYF 1271
+A +L ++P+V++V Y GLP HP H L Q G G V +I GS+ ++ ++ K F
Sbjct: 276 VAQFLESNPQVEKVIYPGLPSHPQHELAKRQCTGCPGMVTFYIKGSLQHAETFLQNLKLF 335
Query: 1272 SIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLAFR 1451
++A S G +SL +P M+HAS+P RE G+++ L+R+S G+ED DL+ DLD A +
Sbjct: 336 TLAESLGGYESLAELPAIMTHASVPKSDREVLGISDTLIRLSVGLEDKQDLLDDLDQALK 395
>sp|Q60HG7|CGL_MACFA Cystathionine gamma-lyase OS=Macaca fascicularis GN=CTH
PE=2 SV=1
Length = 405
Score = 308 bits (787), Expect = 1e-082
Identities = 152/352 (43%), Positives = 232/352 (65%), Gaps = 2/352 (0%)
Frame = +3
Query: 402 TATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALAAVTHLLKS 581
+ TFKQ + ++ ++Y+RSGNPTR+ LE +A LD A F SG+AA +THLLK+
Sbjct: 44 STTFKQAAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKA 103
Query: 582 GDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVWLESPTNPR 761
GD+++ DD+YGG++R V G+ + V+ + ++ + AAI+P TKLVW+E+PTNP
Sbjct: 104 GDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPV 163
Query: 762 QQISDIRKIAEMAHAQG-ALLLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDLMAG 938
++ DI A + H +G +L+VDN+ MSP RPL LGADI M SATK++ GHSD++ G
Sbjct: 164 LKMIDIEACAHIVHKRGDIILVVDNTFMSPYFQRPLALGADICMCSATKYMNGHSDVVMG 223
Query: 939 VLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSTH 1118
++SV E+L L FLQNS G+ +P DC+LC RG+KT+ +R+EK +N +A +L ++
Sbjct: 224 LVSVNCERLHNRLRFLQNSLGAVPSPLDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESN 283
Query: 1119 PRVKQVYYAGLPDHPGHHLHFSQAKG-AGSVFSFITGSVALSKHLVETTKYFSIAVSFGS 1295
P V++V Y GLP HP H L Q G G + +I G++ ++ ++ K F++A S G
Sbjct: 284 PGVEKVIYPGLPSHPQHELAKRQCTGCTGMITFYIKGTLQHAEIFLKNLKLFTLAESLGG 343
Query: 1296 VKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLAFR 1451
+SL+ +P M+HAS+P R+ G+++ L+R+S G+ED DL+ DLD A +
Sbjct: 344 FESLVELPAIMTHASVPKNDRDVLGISDTLIRLSVGLEDEKDLLEDLDQALK 395
>sp|Q19QT7|CGL_PIG Cystathionine gamma-lyase OS=Sus scrofa GN=CTH PE=2 SV=1
Length = 405
Score = 307 bits (786), Expect = 1e-082
Identities = 154/360 (42%), Positives = 233/360 (64%), Gaps = 2/360 (0%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALA 557
A+ P+ + TFKQ + ++ ++Y+RSGNPT + LE +A LD A + F SG+AA
Sbjct: 36 AVVPPISLSTTFKQEAPGQHSGFEYSRSGNPTXNCLEKAVAVLDGAKYSLAFASGLAATV 95
Query: 558 AVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVW 737
+THLLK+G ++++ DD+YGG++R V G+ + V+ + + + AAI+P TKLVW
Sbjct: 96 TITHLLKAGXQIISMDDVYGGTNRYFRQVAAEFGLKISFVDCSKSKLLEAAITPETKLVW 155
Query: 738 LESPTNPRQQISDIRKIAEMAHAQG-ALLLVDNSIMSPVLSRPLELGADIVMHSATKFIA 914
+E+PTNP ++ DI A++ H G +L+VDN+ MS RPL LGADI M+SATK++
Sbjct: 156 IETPTNPILKMIDIEACAQIVHKHGDIILVVDNTFMSAYFQRPLALGADICMYSATKYMN 215
Query: 915 GHSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 1094
GHSD++ G++S+ E L L FLQNS G+ +P DC+LC RG+KT+ +R+EK EN
Sbjct: 216 GHSDVVMGLVSLNSETLHSRLRFLQNSLGAVPSPIDCYLCNRGLKTLQVRMEKHFENGMA 275
Query: 1095 IAMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYF 1271
+A +L +HP V++V Y GLP HP H L Q G + SF I GS+ ++ +++ K F
Sbjct: 276 VAQFLESHPLVEKVIYPGLPSHPQHELAKRQCTGCPGMISFYIKGSLHHAETFLKSLKLF 335
Query: 1272 SIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLAFR 1451
++A S G +SL +P M+H+S+P RE G+ + L+R+S G+ED DL+ DLD A +
Sbjct: 336 TLAESLGGYESLAELPAIMTHSSVPKSDREVLGIRDTLIRLSVGLEDKQDLMDDLDQALK 395
>sp|P18757|CGL_RAT Cystathionine gamma-lyase OS=Rattus norvegicus GN=Cth PE=1
SV=2
Length = 398
Score = 305 bits (780), Expect = 7e-082
Identities = 153/360 (42%), Positives = 233/360 (64%), Gaps = 2/360 (0%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALA 557
A+ P+ TFKQ S ++ + Y+RSGNPTR+ LE +A LD A F G+AA
Sbjct: 35 AVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATT 94
Query: 558 AVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKLVW 737
+THLLK+GDE++ D++YGG++R V G+ + V+ + + + AAI+P+TKLVW
Sbjct: 95 TITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVW 154
Query: 738 LESPTNPRQQISDIRKIAEMAHA-QGALLLVDNSIMSPVLSRPLELGADIVMHSATKFIA 914
+E+PTNP +++DI+ A++ H + +L+VDN+ MS RPL LGADI M SATK++
Sbjct: 155 IETPTNPTLKLADIKACAQIVHKHKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMN 214
Query: 915 GHSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 1094
GHSD++ G++SV + L + L FLQNS G+ +PFDC+LC RG+KT+ +R+EK N
Sbjct: 215 GHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMA 274
Query: 1095 IAMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGA-GSVFSFITGSVALSKHLVETTKYF 1271
+A +L ++PRV++V Y GLP HP H L Q G G V +I G++ ++ ++ K F
Sbjct: 275 VARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLF 334
Query: 1272 SIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLAFR 1451
++A S G +SL +P M+HAS+P + R G+++ L+R+S G+ED DL+ DL A +
Sbjct: 335 ALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALK 394
>sp|P66876|METB_MYCBO Cystathionine gamma-synthase OS=Mycobacterium bovis
GN=metB PE=3 SV=1
Length = 388
Score = 290 bits (740), Expect = 3e-077
Identities = 158/359 (44%), Positives = 222/359 (61%), Gaps = 6/359 (1%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIE-NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL 554
A++ P+Y ++TF Q G ++Y R+GNPTR ALE+ LA +++ A F+SGMAA
Sbjct: 31 AVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLAAVEEGAFARAFSSGMAAT 90
Query: 555 -AAVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKL 731
A+ +L+ GD +V DD YGG+ RL+ V R V V L+ V AAI+PRT+L
Sbjct: 91 DCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRTRL 150
Query: 732 VWLESPTNPRQQISDIRKIAEMAHAQGALLLVDNSIMSPVLSRPLELGADIVMHSATKFI 911
+W+E+PTNP I+DI IAE+ + A +LVDN+ SP L +PL LGAD+V+HS TK+I
Sbjct: 151 IWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPLRLGADVVLHSTTKYI 210
Query: 912 AGHSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENAR 1091
GHSD++ G L E+L +E FLQN G+ PFD +L +RG+KT+ LR+++ ENA
Sbjct: 211 GGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENAC 270
Query: 1092 KIAMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKY 1268
+A +L+ HP V V Y GLP HPGH + Q +G G + S + ++ L T+
Sbjct: 271 AVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMRAGRRAAQDLCAKTRV 330
Query: 1269 FSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLA 1445
F +A S G V+SLI P M+HAS E + +DLVR+S GIED DL+ DL+ A
Sbjct: 331 FILAESLGGVESLIEHPSAMTHASTAGSQLE---VPDDLVRLSVGIEDIADLLGDLEQA 386
>sp|P66875|METB_MYCTU Cystathionine gamma-synthase OS=Mycobacterium tuberculosis
GN=metB PE=3 SV=1
Length = 388
Score = 290 bits (740), Expect = 3e-077
Identities = 158/359 (44%), Positives = 222/359 (61%), Gaps = 6/359 (1%)
Frame = +3
Query: 378 AMSTPLYQTATFKQPSAIE-NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL 554
A++ P+Y ++TF Q G ++Y R+GNPTR ALE+ LA +++ A F+SGMAA
Sbjct: 31 AVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLAAVEEGAFARAFSSGMAAT 90
Query: 555 -AAVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAISPRTKL 731
A+ +L+ GD +V DD YGG+ RL+ V R V V L+ V AAI+PRT+L
Sbjct: 91 DCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRTRL 150
Query: 732 VWLESPTNPRQQISDIRKIAEMAHAQGALLLVDNSIMSPVLSRPLELGADIVMHSATKFI 911
+W+E+PTNP I+DI IAE+ + A +LVDN+ SP L +PL LGAD+V+HS TK+I
Sbjct: 151 IWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPLRLGADVVLHSTTKYI 210
Query: 912 AGHSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENAR 1091
GHSD++ G L E+L +E FLQN G+ PFD +L +RG+KT+ LR+++ ENA
Sbjct: 211 GGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENAC 270
Query: 1092 KIAMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKY 1268
+A +L+ HP V V Y GLP HPGH + Q +G G + S + ++ L T+
Sbjct: 271 AVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMRAGRRAAQDLCAKTRV 330
Query: 1269 FSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLISDLDLA 1445
F +A S G V+SLI P M+HAS E + +DLVR+S GIED DL+ DL+ A
Sbjct: 331 FILAESLGGVESLIEHPSAMTHASTAGSQLE---VPDDLVRLSVGIEDIADLLGDLEQA 386
>sp|P46807|METB_MYCLE Cystathionine gamma-synthase OS=Mycobacterium leprae
GN=metB PE=3 SV=1
Length = 388
Score = 280 bits (716), Expect = 2e-074
Identities = 157/376 (41%), Positives = 228/376 (60%), Gaps = 7/376 (1%)
Frame = +3
Query: 330 VATLLMNLDNKFDP-FDAMSTPLYQTATFKQPSAIE-NGPYDYTRSGNPTRDALESLLAK 503
+AT ++ + DP A++ P+Y ++TF Q E G ++Y R+GNP R ALE+ LA
Sbjct: 14 LATKAIHAGYRPDPATGAVNVPIYASSTFAQDGVGELRGGFEYARTGNPMRAALEASLAT 73
Query: 504 LDKADRAFCFTSGMAAL-AAVTHLLKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVN 680
+++ A F+SGMAA A+ +L+ GD ++ DD+YGG+ RL+ V + V V
Sbjct: 74 VEEGVFARAFSSGMAASDCALRVMLRPGDHVIIPDDVYGGTFRLIDKVFTQWNVDYTPVP 133
Query: 681 TTSLEEVAAAISPRTKLVWLESPTNPRQQISDIRKIAEMAHAQGALLLVDNSIMSPVLSR 860
+ L+ V AAI+ RT+L+W+E+PTNP I+DI I E+ +LVDN+ SP L +
Sbjct: 134 LSDLDAVRAAITSRTRLIWVETPTNPLLSIADITSIGELGKKHSVKVLVDNTFASPALQQ 193
Query: 861 PLELGADIVMHSATKFIAGHSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLR 1040
PL LGAD+V+HS TK+I GHSD++ G L E+L + FLQN G+ +PFD +L +R
Sbjct: 194 PLMLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDQAFGFLQNGAGAVPSPFDAYLTMR 253
Query: 1041 GIKTMALRIEKQQENARKIAMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGAGSVFSF- 1217
G+KT+ LR+++ ENA +A +L+ HP V V Y GLP HPGH + Q +G G + S
Sbjct: 254 GLKTLVLRMQRHNENAITVAEFLAGHPSVSAVLYPGLPSHPGHEVAARQMRGFGGMVSLR 313
Query: 1218 ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRIS 1397
+ ++ L TK F++A S G V+SLI P M+HAS E + +DLVR+S
Sbjct: 314 MRAGRLAAQDLCARTKVFTLAESLGGVESLIEQPSAMTHASTTGSQLE---VPDDLVRLS 370
Query: 1398 AGIEDADDLISDLDLA 1445
GIED DL+ DL A
Sbjct: 371 VGIEDVGDLLCDLKQA 386
>sp|P00935|METB_ECOLI Cystathionine gamma-synthase OS=Escherichia coli (strain
K12) GN=metB PE=1 SV=1
Length = 386
Score = 265 bits (676), Expect = 8e-070
Identities = 148/367 (40%), Positives = 221/367 (60%), Gaps = 2/367 (0%)
Frame = +3
Query: 357 NKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFT 536
N + + + P++ ++T+ E +DY+R GNPTRD ++ LA+L+ A
Sbjct: 15 NDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTN 74
Query: 537 SGMAALAAVTHL-LKSGDELVAGDDLYGGSDRLLSNVVPRSGVVVKRVNTTSLEEVAAAI 713
+GM+A+ VT + LK GD LVA D YGGS RL ++ R V V+ + + AA+
Sbjct: 75 TGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAAL 134
Query: 714 SPRTKLVWLESPTNPRQQISDIRKIAEMAHAQGALLLVDNSIMSPVLSRPLELGADIVMH 893
+ + KLV +ESP+NP ++ DI KI +A GA+ +VDN+ +SP L PL LGAD+V+H
Sbjct: 135 AEKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLH 194
Query: 894 SATKFIAGHSDLMAGVLSVKGEQLAKELYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEK 1073
S TK++ GHSD++AGV+ K + EL + N+ G FD +L LRG++T+ R+E
Sbjct: 195 SCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMEL 254
Query: 1074 QQENARKIAMYLSTHPRVKQVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHL 1250
Q NA+ I YL T P VK++Y+ LP++ GH + Q KG G++ SF + G +
Sbjct: 255 AQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRF 314
Query: 1251 VETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDADDLIS 1430
+ F++A S G V+SLIS M+HA + E R A G++E L+RIS GIED +DLI+
Sbjct: 315 LGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIA 374
Query: 1431 DLDLAFR 1451
DL+ FR
Sbjct: 375 DLENGFR 381
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,894,514,945
Number of Sequences: 518415
Number of Extensions: 45894514945
Number of Successful Extensions: 338263929
Number of sequences better than 0.0: 0
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