BLASTX 7.6.2
Query= UN10888 /QuerySize=1884
(1883 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q15751|HERC1_HUMAN Probable E3 ubiquitin-protein ligase HERC1... 99 1e-019
sp|Q9VR91|HERC2_DROME Probable E3 ubiquitin-protein ligase HERC2... 98 2e-019
sp|O95714|HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 OS=Homo ... 94 4e-018
sp|Q4U2R1|HERC2_MOUSE E3 ubiquitin-protein ligase HERC2 OS=Mus m... 92 1e-017
sp|Q8IVU3|HERC6_HUMAN Probable E3 ubiquitin-protein ligase HERC6... 91 3e-017
sp|Q8SSY6|SPKUL_DICDI Bifunctional serine/threonine-protein kina... 84 2e-015
sp|Q15034|HERC3_HUMAN Probable E3 ubiquitin-protein ligase HERC3... 83 7e-015
sp|Q91ZR4|NEK8_MOUSE Serine/threonine-protein kinase Nek8 OS=Mus... 81 3e-014
sp|Q86SG6|NEK8_HUMAN Serine/threonine-protein kinase Nek8 OS=Hom... 78 2e-013
>sp|Q15751|HERC1_HUMAN Probable E3 ubiquitin-protein ligase HERC1 OS=Homo
sapiens GN=HERC1 PE=1 SV=2
Length = 4861
Score = 99 bits (244), Expect = 1e-019
Identities = 44/96 (45%), Positives = 65/96 (67%), Gaps = 2/96 (2%)
Frame = -1
Query: 1745 VQGLDDLTLVDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAG 1566
+QG LV HS ALTE GEV++WG G++G+LG G++D+ + P+++ L G
Sbjct: 4076 LQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRR--PRQIEALQG 4133
Query: 1565 ENIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYG 1458
E ++Q+SCG HS +T DG++F+FG GD+GRLG G
Sbjct: 4134 EEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLG 4169
>sp|Q9VR91|HERC2_DROME Probable E3 ubiquitin-protein ligase HERC2 OS=Drosophila
melanogaster GN=HERC2 PE=1 SV=3
Length = 4912
Score = 98 bits (242), Expect = 2e-019
Identities = 49/112 (43%), Positives = 71/112 (63%), Gaps = 4/112 (3%)
Frame = -1
Query: 1754 PIPVQGLDDLTLVDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNL 1575
P V+ L + D+A G HS A++ QGE+Y WG GE+GRLG GDN ++++ P+ V
Sbjct: 3116 PRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDN--TTQLKPKLVTA 3173
Query: 1574 LAGENIIQVSCGG--THSVALTRDGRIFSFGRGDHGRLGYGRKVTTGQPSEL 1425
LAG ++QV+CG ++ALT DG +FS+G GD G+LG G + P E+
Sbjct: 3174 LAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEI 3225
Score = 86 bits (210), Expect = 1e-015
Identities = 42/111 (37%), Positives = 66/111 (59%), Gaps = 2/111 (1%)
Frame = -1
Query: 1766 PRSHPIPVQGLDDLTLVDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQ 1587
P H +PV + V + +GG H+ ALT G+V++WG GE G+LG G+ K P+
Sbjct: 3060 PLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDK--PR 3117
Query: 1586 KVNLLAGENIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYGRKVTTGQP 1434
V L + I V+CG +HS A++ G ++++G G++GRLG+G T +P
Sbjct: 3118 LVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKP 3168
Score = 80 bits (196), Expect = 5e-014
Identities = 39/101 (38%), Positives = 62/101 (61%), Gaps = 4/101 (3%)
Frame = -1
Query: 1754 PIPVQGLDDLTLVDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNL 1575
P V+ L+ +++ DIA G HS A+T G V WG+G +GRLG GD++ ++ P+ V
Sbjct: 4179 PKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSE--DQLRPKLVEA 4236
Query: 1574 LAGENIIQVSCGG--THSVALTRDGRIFSFGRGDHGRLGYG 1458
L G I ++CG ++ +T D ++S+G GD+G+LG G
Sbjct: 4237 LLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRG 4277
Score = 77 bits (188), Expect = 4e-013
Identities = 39/101 (38%), Positives = 62/101 (61%), Gaps = 4/101 (3%)
Frame = -1
Query: 1754 PIPVQGLDDLTLVDIAAGG--WHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKV 1581
P V L +V +A G + ALTE G V++WG G+ G+LG G ++ S P ++
Sbjct: 3168 PKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSD--TPHEI 3225
Query: 1580 NLLAGENIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYG 1458
L+G ++Q+ CG S+ALTR G ++++G+GD+ RLG+G
Sbjct: 3226 ERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHG 3266
Score = 77 bits (187), Expect = 5e-013
Identities = 39/101 (38%), Positives = 61/101 (60%), Gaps = 4/101 (3%)
Frame = -1
Query: 1754 PIPVQGLDDLTLVDIAAGGWHSTAL--TEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKV 1581
P V+ L +DIA G + L T+ V++WG G++G+LG G +D +P K+
Sbjct: 4231 PKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCK--LPYKI 4288
Query: 1580 NLLAGENIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYG 1458
LAG +++V CG SVALT+ G ++++G+GD RLG+G
Sbjct: 4289 ESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHG 4329
>sp|O95714|HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens
GN=HERC2 PE=1 SV=1
Length = 4834
Score = 94 bits (231), Expect = 4e-018
Identities = 47/101 (46%), Positives = 66/101 (65%), Gaps = 4/101 (3%)
Frame = -1
Query: 1754 PIPVQGLDDLTLVDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNL 1575
P ++ L + DIA G HS ALT GE+Y WG GE+GRLG GDN ++++ P+ V +
Sbjct: 3090 PRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDN--TTQLKPKMVKV 3147
Query: 1574 LAGENIIQVSCGG--THSVALTRDGRIFSFGRGDHGRLGYG 1458
L G +IQV+CG ++ALT +G +FS+G GD G+LG G
Sbjct: 3148 LLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3188
Score = 87 bits (213), Expect = 5e-016
Identities = 44/103 (42%), Positives = 66/103 (64%), Gaps = 4/103 (3%)
Frame = -1
Query: 1754 PIPVQGLDDLTLVDIAA--GGWHSTALTEQGEVYAWGRGEHGRLGFGDND--KSSKMVPQ 1587
P VQGL +V IAA G H AL GEVY+WG G+ GRLG GD + K++
Sbjct: 484 PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 543
Query: 1586 KVNLLAGENIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYG 1458
AG++++ ++CG T+S A+T +G ++++GRG++GRLG+G
Sbjct: 544 FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHG 586
Score = 87 bits (213), Expect = 5e-016
Identities = 40/105 (38%), Positives = 64/105 (60%), Gaps = 4/105 (3%)
Frame = -1
Query: 1766 PRSHPIPVQGLDDLTLVDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQ 1587
P P ++ L + +VD+AAGG HS +T G++Y WG+G +GRLG D++ K P+
Sbjct: 4078 PCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLK--PK 4135
Query: 1586 KVNLLAGENIIQVSCGG--THSVALTRDGRIFSFGRGDHGRLGYG 1458
V L G ++ ++CG ++ LT D ++S+G GD+G+LG G
Sbjct: 4136 LVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRG 4180
Score = 80 bits (197), Expect = 4e-014
Identities = 37/100 (37%), Positives = 61/100 (61%), Gaps = 2/100 (2%)
Frame = -1
Query: 1718 VDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAGENIIQVSCG 1539
V + +GG H+TALT G+V++WG G+ G+LG K P+ + L + I ++CG
Sbjct: 3050 VAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDK--PRLIEALKTKRIRDIACG 3107
Query: 1538 GTHSVALTRDGRIFSFGRGDHGRLGYGRKVTTGQPSELPI 1419
+HS ALT G ++++G G++GRLG+G T +P + +
Sbjct: 3108 SSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKV 3147
Score = 80 bits (197), Expect = 4e-014
Identities = 41/112 (36%), Positives = 67/112 (59%), Gaps = 4/112 (3%)
Frame = -1
Query: 1754 PIPVQGLDDLTLVDIAAGGW--HSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKV 1581
P V+ L +VDIA G + LT+ V++WG G++G+LG G +D VP K+
Sbjct: 4134 PKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCK--VPMKI 4191
Query: 1580 NLLAGENIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYGRKVTTGQPSEL 1425
+ L G +++V CG SVALT+ G ++++G+GD+ RLG+G +P ++
Sbjct: 4192 DSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQV 4243
>sp|Q4U2R1|HERC2_MOUSE E3 ubiquitin-protein ligase HERC2 OS=Mus musculus
GN=Herc2 PE=1 SV=2
Length = 4836
Score = 92 bits (227), Expect = 1e-017
Identities = 47/101 (46%), Positives = 65/101 (64%), Gaps = 4/101 (3%)
Frame = -1
Query: 1754 PIPVQGLDDLTLVDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNL 1575
P +Q L + DIA G HS LT GE+Y WG GE+GRLG GDN ++++ P+ V +
Sbjct: 3091 PRLIQALKTKRIRDIAYGSSHSAPLTSSGELYTWGLGEYGRLGHGDN--TTQLKPKMVKV 3148
Query: 1574 LAGENIIQVSCGG--THSVALTRDGRIFSFGRGDHGRLGYG 1458
L G +IQV+CG ++ALT +G +FS+G GD G+LG G
Sbjct: 3149 LLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3189
Score = 87 bits (214), Expect = 4e-016
Identities = 41/105 (39%), Positives = 64/105 (60%), Gaps = 4/105 (3%)
Frame = -1
Query: 1766 PRSHPIPVQGLDDLTLVDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQ 1587
P P ++ L + +VD+AAGG HS +T G++Y WG+G +GRLG D++ K P+
Sbjct: 4080 PCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLK--PK 4137
Query: 1586 KVNLLAGENIIQVSCGG--THSVALTRDGRIFSFGRGDHGRLGYG 1458
V L G +I ++CG ++ LT D ++S+G GD+G+LG G
Sbjct: 4138 LVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRG 4182
Score = 87 bits (213), Expect = 5e-016
Identities = 44/103 (42%), Positives = 66/103 (64%), Gaps = 4/103 (3%)
Frame = -1
Query: 1754 PIPVQGLDDLTLVDIAA--GGWHSTALTEQGEVYAWGRGEHGRLGFGDND--KSSKMVPQ 1587
P VQGL +V IAA G H AL GEVY+WG G+ GRLG GD + K++
Sbjct: 485 PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 544
Query: 1586 KVNLLAGENIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYG 1458
AG++++ ++CG T+S A+T +G ++++GRG++GRLG+G
Sbjct: 545 FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHG 587
Score = 80 bits (196), Expect = 5e-014
Identities = 40/112 (35%), Positives = 67/112 (59%), Gaps = 4/112 (3%)
Frame = -1
Query: 1754 PIPVQGLDDLTLVDIAAGGW--HSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKV 1581
P V+ L ++DIA G + LT+ V++WG G++G+LG G +D VP K+
Sbjct: 4136 PKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCK--VPMKI 4193
Query: 1580 NLLAGENIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYGRKVTTGQPSEL 1425
+ L G +++V CG SVALT+ G ++++G+GD+ RLG+G +P ++
Sbjct: 4194 DSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQV 4245
>sp|Q8IVU3|HERC6_HUMAN Probable E3 ubiquitin-protein ligase HERC6 OS=Homo
sapiens GN=HERC6 PE=2 SV=2
Length = 1022
Score = 91 bits (223), Expect = 3e-017
Identities = 43/101 (42%), Positives = 65/101 (64%), Gaps = 1/101 (0%)
Frame = -1
Query: 1754 PIPVQGLDDLTLVDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNL 1575
P P+Q L+ L + ++ G HS A+ +G V+AWG G G+LG G+ K P+K+
Sbjct: 66 PEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGE-FKEISFTPKKIMT 124
Query: 1574 LAGENIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYGRK 1452
L IIQVSCG HS+AL++D ++FS+G+ HG+LG G++
Sbjct: 125 LNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKE 165
>sp|Q8SSY6|SPKUL_DICDI Bifunctional serine/threonine-protein kinase/NEDD4-like
E3 ubiquitin-protein ligase OS=Dictyostelium discoideum GN=DDB_G0276527
PE=3 SV=2
Length = 1887
Score = 84 bits (207), Expect = 2e-015
Identities = 48/140 (34%), Positives = 76/140 (54%), Gaps = 7/140 (5%)
Frame = -1
Query: 1727 LTLVDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAGENIIQV 1548
+ +V ++ G S +T++G ++ +GRG+HGRLG G+ + P+ V L G II +
Sbjct: 338 IKIVKLSCGTNRSAVITDKGLLFTFGRGDHGRLGLGEQSLLMQSTPKLVQSLQGHFIIDM 397
Query: 1547 SCGGTHSVALTRDGRIFSFGRGDHGRLGYGRKVTTGQPSELPIEIPPPEGQFNHADEEED 1368
S GG HS+ LT G +FSFGR D G+LG G + Q + IP F + +++
Sbjct: 398 SSGGGHSLVLTNKGLVFSFGRNDQGQLGIG--CFSNQQT-----IPKQIQWFQTSQQQQQ 450
Query: 1367 GKWIAKFVACGGRHTLAIME 1308
V+ GG H++AI +
Sbjct: 451 QPINIIKVSAGGYHSIAISD 470
>sp|Q15034|HERC3_HUMAN Probable E3 ubiquitin-protein ligase HERC3 OS=Homo
sapiens GN=HERC3 PE=1 SV=1
Length = 1050
Score = 83 bits (203), Expect = 7e-015
Identities = 38/101 (37%), Positives = 63/101 (62%), Gaps = 1/101 (0%)
Frame = -1
Query: 1754 PIPVQGLDDLTLVDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNL 1575
P + L D ++ +A G HS AL+++G++++WG G G+LG + S VP+ +
Sbjct: 75 PEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE-DSVAVPRLIQK 133
Query: 1574 LAGENIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYGRK 1452
L + I+QVSCG H +AL DG+ F++G+ HG+LG G++
Sbjct: 134 LNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE 174
>sp|Q91ZR4|NEK8_MOUSE Serine/threonine-protein kinase Nek8 OS=Mus musculus
GN=Nek8 PE=1 SV=1
Length = 698
Score = 81 bits (198), Expect = 3e-014
Identities = 42/117 (35%), Positives = 69/117 (58%), Gaps = 3/117 (2%)
Frame = -1
Query: 1745 VQGLDDLTLVDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAG 1566
++G +T+ +A G + LT++G + +G G +G LG G+ S+ P V L G
Sbjct: 391 LEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQ--PTIVEALLG 448
Query: 1565 ENIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYGRKVTTGQPSELPIEIPPPEGQ 1395
++QV+CG +H +AL+ DG +F++GRGD GRLG G + + P ++P+ P E Q
Sbjct: 449 YEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPV-APGQEAQ 504
>sp|Q86SG6|NEK8_HUMAN Serine/threonine-protein kinase Nek8 OS=Homo sapiens
GN=NEK8 PE=1 SV=1
Length = 692
Score = 78 bits (191), Expect = 2e-013
Identities = 41/117 (35%), Positives = 67/117 (57%), Gaps = 6/117 (5%)
Frame = -1
Query: 1745 VQGLDDLTLVDIAAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAG 1566
++G +T+ +A G + + LT++G + +G G +G LG G S+ P V L G
Sbjct: 385 LEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQ--PTIVEALLG 442
Query: 1565 ENIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYGRKVTTGQPSELPIEIPPPEGQ 1395
++QV+CG +H +AL+ + +F++GRGD GRLG G T + P ++P P GQ
Sbjct: 443 YEMVQVACGASHVLALSTERELFAWGRGDSGRLGLG----TRESHSCPQQVPMPPGQ 495
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,894,514,945
Number of Sequences: 518415
Number of Extensions: 45894514945
Number of Successful Extensions: 338263929
Number of sequences better than 0.0: 0
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