BLASTX 7.6.2
Query= UN11002 /QuerySize=1219
(1218 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5R6D1|CATB_PONAB Cathepsin B OS=Pongo abelii GN=CTSB PE=2 SV=1 228 1e-058
sp|P07858|CATB_HUMAN Cathepsin B OS=Homo sapiens GN=CTSB PE=1 SV=3 227 2e-058
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase OS=Sch... 215 7e-055
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase OS=Sch... 215 9e-055
sp|Q54QD9|CTSB_DICDI Cathepsin B OS=Dictyostelium discoideum GN=... 193 4e-048
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase OS=Caenorh... 192 5e-048
sp|P43507|CPR3_CAEEL Cathepsin B-like cysteine proteinase 3 OS=C... 173 2e-042
sp|P25802|CYSP1_OSTOS Cathepsin B-like cysteine proteinase 1 OS=... 162 7e-039
sp|Q4R5M2|CATB_MACFA Cathepsin B OS=Macaca fascicularis GN=CTSB ... 138 1e-031
sp|A1E295|CATB_PIG Cathepsin B OS=Sus scrofa GN=CTSB PE=1 SV=1 130 2e-029
sp|Q06544|CYSP3_OSTOS Cathepsin B-like cysteine proteinase 3 (Fr... 112 8e-024
sp|P07688|CATB_BOVIN Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5 111 1e-023
sp|P43233|CATB_CHICK Cathepsin B OS=Gallus gallus GN=CTSB PE=2 SV=1 111 1e-023
sp|P00787|CATB_RAT Cathepsin B OS=Rattus norvegicus GN=Ctsb PE=1... 111 2e-023
sp|P10605|CATB_MOUSE Cathepsin B OS=Mus musculus GN=Ctsb PE=1 SV=2 110 2e-023
sp|P43508|CPR4_CAEEL Cathepsin B-like cysteine proteinase 4 OS=C... 102 5e-021
sp|P25793|CYSP2_HAECO Cathepsin B-like cysteine proteinase 2 OS=... 98 1e-019
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 OS=C... 97 3e-019
>sp|Q5R6D1|CATB_PONAB Cathepsin B OS=Pongo abelii GN=CTSB PE=2 SV=1
Length = 339
Score = 228 bits (579), Expect = 1e-058
Identities = 122/274 (44%), Positives = 164/274 (59%), Gaps = 29/274 (10%)
Frame = +2
Query: 194 LQEEIVKKVNEHPNAGWKAAINDRFSNATVAEFKRLLGVKPTPKKLLLGVP----FVSHD 361
L +E+V VN+ N W+A N F N V+ K+L G LG P V
Sbjct: 26 LSDELVNYVNKR-NTTWQAGHN--FYNVDVSYLKKLCGT-------FLGGPKPPQRVMFT 75
Query: 362 QSLKLPKSFDARTHWPQCTSIGNILYQGHCGSCWAFGAVESLSDRFCIQFGMNITLSVN- 538
+ LKLP+SFDAR WPQC +I I QG CGSCWAFGAVE++SDR CI ++++ V+
Sbjct: 76 EDLKLPESFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSA 135
Query: 539 -DLLAYCGFRCCDGCDGGYPISAWQYFSYSGVVT-------EECDPYF-----DQTGCSH 679
DLL CG C DGC+GGYP AW +++ G+V+ C PY S
Sbjct: 136 EDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSR 195
Query: 680 PGCEPAYNTPQCLRKC-VGRNQLWSESKHYSVNTYVVESNPQDIMAEIYKNGPVEVSFTV 856
P C +TP+C + C G + + + KHY N+Y V ++ +DIMAEIYKNGPVE +F+V
Sbjct: 196 PPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSERDIMAEIYKNGPVEGAFSV 255
Query: 857 YEDFAHYKSGVYKHITGSNIGGHAVKLIGWGTKN 958
Y DF YKSGVY+H+TG +GGHA++++GWG +N
Sbjct: 256 YSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVEN 289
>sp|P07858|CATB_HUMAN Cathepsin B OS=Homo sapiens GN=CTSB PE=1 SV=3
Length = 339
Score = 227 bits (577), Expect = 2e-058
Identities = 122/274 (44%), Positives = 163/274 (59%), Gaps = 29/274 (10%)
Frame = +2
Query: 194 LQEEIVKKVNEHPNAGWKAAINDRFSNATVAEFKRLLGVKPTPKKLLLGVP----FVSHD 361
L +E+V VN+ N W+A N F N ++ KRL G LG P V
Sbjct: 26 LSDELVNYVNKR-NTTWQAGHN--FYNVDMSYLKRLCGT-------FLGGPKPPQRVMFT 75
Query: 362 QSLKLPKSFDARTHWPQCTSIGNILYQGHCGSCWAFGAVESLSDRFCIQFGMNITLSVN- 538
+ LKLP SFDAR WPQC +I I QG CGSCWAFGAVE++SDR CI ++++ V+
Sbjct: 76 EDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSA 135
Query: 539 -DLLAYCGFRCCDGCDGGYPISAWQYFSYSGVVT-------EECDPYF-----DQTGCSH 679
DLL CG C DGC+GGYP AW +++ G+V+ C PY S
Sbjct: 136 EDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSR 195
Query: 680 PGCEPAYNTPQCLRKC-VGRNQLWSESKHYSVNTYVVESNPQDIMAEIYKNGPVEVSFTV 856
P C +TP+C + C G + + + KHY N+Y V ++ +DIMAEIYKNGPVE +F+V
Sbjct: 196 PPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSV 255
Query: 857 YEDFAHYKSGVYKHITGSNIGGHAVKLIGWGTKN 958
Y DF YKSGVY+H+TG +GGHA++++GWG +N
Sbjct: 256 YSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVEN 289
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase OS=Schistosoma
japonicum GN=CATB PE=2 SV=1
Length = 342
Score = 215 bits (546), Expect = 7e-055
Identities = 115/272 (42%), Positives = 159/272 (58%), Gaps = 21/272 (7%)
Frame = +2
Query: 194 LQEEIVKKVNEHPNAGWKAAINDRFSNATVAEFKRLLGVKPTPKKLLLG-VPFVS-HDQS 367
L +E++ +NEHP+AGWKA +DRF + A L+G + ++ P V HD +
Sbjct: 30 LSDEMISFINEHPDAGWKADKSDRFHSLDDARI--LMGARKEDAEMKRNRRPTVDHHDLN 87
Query: 368 LKLPKSFDARTHWPQCTSIGNILYQGHCGSCWAFGAVESLSDRFCIQF--GMNITLSVND 541
+++P FD+R WP C SI I Q CGSCWAFGAVE+++DR CIQ G + LS D
Sbjct: 88 VEIPSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALD 147
Query: 542 LLAYCGFRCCDGCDGGYPISAWQYFSYSGVVT-------EECDPY-----FDQTGCSHPG 685
L++ C C DGC GG+P AW Y+ G+VT C PY T +P
Sbjct: 148 LISCCK-DCGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPA 206
Query: 686 C-EPAYNTPQCLRKC-VGRNQLWSESKHYSVNTYVVESNPQDIMAEIYKNGPVEVSFTVY 859
C Y TPQC + C G + + KHY +Y V++N + I +I GPVE +F VY
Sbjct: 207 CGTKIYKTPQCKQTCQKGYKTPYEQDKHYGDESYNVQNNEKVIQRDIMMYGPVEAAFDVY 266
Query: 860 EDFAHYKSGVYKHITGSNIGGHAVKLIGWGTK 955
EDF +YKSG+Y+H+TGS +GGHA+++IGWG +
Sbjct: 267 EDFLNYKSGIYRHVTGSIVGGHAIRIIGWGVE 298
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase OS=Schistosoma
mansoni PE=2 SV=1
Length = 340
Score = 215 bits (545), Expect = 9e-055
Identities = 116/272 (42%), Positives = 162/272 (59%), Gaps = 19/272 (6%)
Frame = +2
Query: 194 LQEEIVKKVNEHPNAGWKAAINDRFSNATVAEFKRLLGVKPTPKKLLLGVPFVSH-DQSL 370
L ++I+ +NEHPNAGW+A ++RF + A ++ + P P V H D ++
Sbjct: 29 LSDDIISYINEHPNAGWRAEKSNRFHSLDDARI-QMGARREEPDLRRKRRPTVDHNDWNV 87
Query: 371 KLPKSFDARTHWPQCTSIGNILYQGHCGSCWAFGAVESLSDRFCIQFG--MNITLSVNDL 544
++P +FD+R WP C SI I Q CGSCW+FGAVE++SDR CIQ G N+ LS DL
Sbjct: 88 EIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDL 147
Query: 545 LAYCGFRCCDGCDGGYPISAWQYFSYSGVVTEE-------CDPY-----FDQTGCSHPGC 688
L C C GC+GG AW Y+ G+VT C+PY T +P C
Sbjct: 148 LTCCE-SCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPC 206
Query: 689 -EPAYNTPQCLRKCVGRNQL-WSESKHYSVNTYVVESNPQDIMAEIYKNGPVEVSFTVYE 862
YNTP+C + C + + +++ KH ++Y V+++ + I EI K GPVE SFTVYE
Sbjct: 207 GSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYE 266
Query: 863 DFAHYKSGVYKHITGSNIGGHAVKLIGWGTKN 958
DF +YKSG+YKHITG +GGHA+++IGWG +N
Sbjct: 267 DFLNYKSGIYKHITGEALGGHAIRIIGWGVEN 298
>sp|Q54QD9|CTSB_DICDI Cathepsin B OS=Dictyostelium discoideum GN=ctsB PE=3 SV=1
Length = 311
Score = 193 bits (488), Expect = 4e-048
Identities = 109/252 (43%), Positives = 143/252 (56%), Gaps = 31/252 (12%)
Frame = +2
Query: 242 WKAAINDRFSNATVAEFKRLLGVKPTPKKLLLGVPFVSHDQ-SLKLPKSFDARTHWPQCT 418
W D+F N V + LLG K +P + L + S+D +++P SF+A+T+WP CT
Sbjct: 39 WVEEQTDQFDNIKVGQ---LLGFKRSPNRPKLQIK--SYDPLGVQIPTSFNAQTNWPNCT 93
Query: 419 SIGNILYQGHCGSCWAFGAVESLSDRFCIQFGMNITLSVNDLLAYCGFRCCD----GCDG 586
+I I Q CGSCWAFGA ES +DR CI N+ LS D++ CD GC+G
Sbjct: 94 TISQIQNQARCGSCWAFGATESATDRLCIHNNENVQLSFMDMVT------CDETDNGCEG 147
Query: 587 GYPISAWQYFSYSGVVTEECDPYFDQTGCSHPGCEPA-------YNTPQCLRKCVGRNQL 745
G SAW + G V+EEC PY + P C PA NTP C ++C + L
Sbjct: 148 GDAFSAWNWLRKQGAVSEECLPY------TIPTCPPAQQPCLNFVNTPSCTKECQSNSSL 201
Query: 746 -WSESKHYSVNTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGG 922
+S+ KH Y +S+ + IM EI NGPVE FTV+EDF YKSGVY H TG ++GG
Sbjct: 202 IYSQDKHKMAKIYSFDSD-EAIMQEIVTNGPVEACFTVFEDFLAYKSGVYVHTTGKDLGG 260
Query: 923 HAVKLIGWGTKN 958
H VKL+G+GT N
Sbjct: 261 HCVKLVGFGTLN 272
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase OS=Caenorhabditis elegans
GN=cpr-1 PE=1 SV=2
Length = 329
Score = 192 bits (487), Expect = 5e-048
Identities = 97/204 (47%), Positives = 125/204 (61%), Gaps = 11/204 (5%)
Frame = +2
Query: 374 LPKSFDARTHWPQCTSIGNILYQGHCGSCWAFGAVESLSDRFCIQF--GMNITLSVNDLL 547
+P +FD+RT W +C SI I Q CGSCWAFGA E +SDR CI+ +S +DLL
Sbjct: 85 VPATFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLL 144
Query: 548 AYCGFRCCDGCDGGYPISAWQYFSYSGVVT------EECDPYFDQTGCSHPGCEPAYNTP 709
+ CG C +GC+GGYPI A +++ GVVT C PY C+ C P TP
Sbjct: 145 SCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDYHGAGCKPY-PIAPCTSGNC-PESKTP 202
Query: 710 QCLRKC-VGRNQLWSESKHYSVNTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSG 886
C C G + +++ KH+ V+ Y V N I AEIY NGPVE +F+VYEDF YKSG
Sbjct: 203 SCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYANGPVEAAFSVYEDFYKYKSG 262
Query: 887 VYKHITGSNIGGHAVKLIGWGTKN 958
VYKH G +GGHA+K+IGWGT++
Sbjct: 263 VYKHTAGKYLGGHAIKIIGWGTES 286
>sp|P43507|CPR3_CAEEL Cathepsin B-like cysteine proteinase 3 OS=Caenorhabditis
elegans GN=cpr-3 PE=2 SV=1
Length = 370
Score = 173 bits (438), Expect = 2e-042
Identities = 94/207 (45%), Positives = 118/207 (57%), Gaps = 15/207 (7%)
Frame = +2
Query: 374 LPKSFDARTHWPQCTSIGNILYQGHCGSCWAFGAVESLSDRFCIQFG--MNITLSVNDLL 547
LP +FDAR WP C +I I Q CGSCWAFGA E +SDR CIQ +SV D+L
Sbjct: 92 LPDTFDAREKWPDCNTIKLIRNQATCGSCWAFGAAEVISDRVCIQSNGTQQPVISVEDIL 151
Query: 548 AYCGFRCCDGCDGGYPISAWQYFSYSGVVT------EECDPYFDQTGCSHPGCEPAYNTP 709
+ CG C GC GGY I A ++++ SG VT C PY C+ C P TP
Sbjct: 152 SCCGTTCGYGCKGGYSIEALRFWASSGAVTGGDYGGHGCMPY-SFAPCT-KNC-PESTTP 208
Query: 710 QCLRKCVG--RNQLWSESKHYSVNTYVVESNPQ--DIMAEIYKNGPVEVSFTVYEDFAHY 877
C C + + + + KHY + Y V + +I EIY GPVE S+ VYEDF HY
Sbjct: 209 SCKTTCQSSYKTEEYKKDKHYGASAYKVTTTKSVTEIQTEIYHYGPVEASYKVYEDFYHY 268
Query: 878 KSGVYKHITGSNIGGHAVKLIGWGTKN 958
KSGVY + +G +GGHAVK+IGWG +N
Sbjct: 269 KSGVYHYTSGKLVGGHAVKIIGWGVEN 295
>sp|P25802|CYSP1_OSTOS Cathepsin B-like cysteine proteinase 1 OS=Ostertagia
ostertagi GN=CP-1 PE=3 SV=3
Length = 341
Score = 162 bits (408), Expect = 7e-039
Identities = 84/208 (40%), Positives = 123/208 (59%), Gaps = 18/208 (8%)
Frame = +2
Query: 374 LPKSFDARTHWPQCTSIGNILYQGHCGSCWAFGAVESLSDRFCI--QFGMNITLSVNDLL 547
+P+S+D R W C+S+ +I Q +CGSCWA + ++SDR CI + + +S D++
Sbjct: 91 IPESYDPRIQWANCSSLFHIPDQANCGSCWAVSSAAAMSDRICIASKGAKQVLISAQDVV 150
Query: 548 AYCGFRCCDGCDGGYPISAWQYFSYSGVVT-------EECDPYFDQTGCSHPGCEPAY-- 700
+ C + C DGC+GG+PISA+++ + GVVT C PY + C H G E Y
Sbjct: 151 SCCTW-CGDGCEGGWPISAFRFHADEGVVTGGDYNTKGSCRPY-EIHPCGHHGNETYYGE 208
Query: 701 -----NTPQCLRKCVGRNQLWSESKHYSVNTYVVESNPQDIMAEIYKNGPVEVSFTVYED 865
+TP+C R+C+ S Y Y ++++ + I +I KNGPV ++TVYED
Sbjct: 209 CVGMADTPRCKRRCLLGYPKSYPSDRYYKKAYQLKNSVKAIQKDIMKNGPVVATYTVYED 268
Query: 866 FAHYKSGVYKHITGSNIGGHAVKLIGWG 949
FAHY+SG+YKH G G HAVK+IGWG
Sbjct: 269 FAHYRSGIYKHKAGRKTGLHAVKVIGWG 296
>sp|Q4R5M2|CATB_MACFA Cathepsin B OS=Macaca fascicularis GN=CTSB PE=2 SV=1
Length = 339
Score = 138 bits (345), Expect = 1e-031
Identities = 80/180 (44%), Positives = 103/180 (57%), Gaps = 24/180 (13%)
Frame = +2
Query: 194 LQEEIVKKVNEHPNAGWKAAINDRFSNATVAEFKRLLGVKPTPKKLLLGVP----FVSHD 361
L +E+V VN+ N W+A N F N V+ KRL G LG P V
Sbjct: 26 LSDELVNYVNKQ-NTTWQAGHN--FYNVDVSYLKRLCGT-------FLGGPKPPQRVMFT 75
Query: 362 QSLKLPKSFDARTHWPQCTSIGNILYQGHCGSCWAFGAVESLSDRFCIQFGMNITLSVN- 538
+ LKLP+SFDAR WPQC +I I QG CGSCWAFGAVE++SDR CI ++++ V+
Sbjct: 76 EDLKLPESFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSA 135
Query: 539 -DLLAYCGFRCCDGCDGGYPISAWQYFSYSGVVTEECDPYFDQTGCSHPGCEPAYNTPQC 715
DLL CG C DGC+GGYP AW +++ G+V+ +D SH GC P Y+ P C
Sbjct: 136 EDLLTCCGIMCGDGCNGGYPAGAWNFWTRKGLVS---GGLYD----SHVGCRP-YSIPPC 187
Score = 115 bits (286), Expect = 1e-024
Identities = 54/122 (44%), Positives = 76/122 (62%), Gaps = 1/122 (0%)
Frame = +2
Query: 596 ISAWQYFSYSGVVTEECDPYFDQTGCSHPGCEPAYNTPQCLRKC-VGRNQLWSESKHYSV 772
+S Y S+ G P S P C +TP+C + C G + + + KHY
Sbjct: 168 VSGGLYDSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGY 227
Query: 773 NTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGT 952
N+Y V ++ +DIMAEIYKNGPVE +F+VY DF YKSGVY+H+TG +GGHA++++GWG
Sbjct: 228 NSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGV 287
Query: 953 KN 958
+N
Sbjct: 288 EN 289
>sp|A1E295|CATB_PIG Cathepsin B OS=Sus scrofa GN=CTSB PE=1 SV=1
Length = 335
Score = 130 bits (326), Expect = 2e-029
Identities = 74/184 (40%), Positives = 104/184 (56%), Gaps = 16/184 (8%)
Frame = +2
Query: 170 KQKLNSKILQEEIVKKVNEHPNAGWKAAINDRFSNATVAEFKRLLGVKPTPKKLLLGVPF 349
++ L+ + L +E+V +N+ N W A N F N ++ K+L G KL F
Sbjct: 18 RESLHFQPLSDELVNFINKQ-NTTWTAGHN--FYNVDLSYVKKLCGTFLGGPKLPQRAAF 74
Query: 350 VSHDQSLKLPKSFDARTHWPQCTSIGNILYQGHCGSCWAFGAVESLSDRFCIQFG--MNI 523
+ + LPKSFDAR WP C +I I QG CGSCWAFGAVE++SDR CI+ +N+
Sbjct: 75 AA---DMILPKSFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIRSNGRVNV 131
Query: 524 TLSVNDLLAYCGFRCCDGCDGGYPISAWQYFSYSGVVTEECDPYFDQTGCSHPGCEPAYN 703
+S D+L CG C DGC+GG+P AW +++ G+V+ +D SH GC P Y+
Sbjct: 132 EVSAEDMLTCCGDECGDGCNGGFPSGAWNFWTKKGLVS---GGLYD----SHVGCRP-YS 183
Query: 704 TPQC 715
P C
Sbjct: 184 IPPC 187
Score = 113 bits (282), Expect = 3e-024
Identities = 53/122 (43%), Positives = 74/122 (60%), Gaps = 1/122 (0%)
Frame = +2
Query: 596 ISAWQYFSYSGVVTEECDPYFDQTGCSHPGCEPAYNTPQCLRKC-VGRNQLWSESKHYSV 772
+S Y S+ G P S P C +TP+C + C G + E KH+
Sbjct: 168 VSGGLYDSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYTPSYKEDKHFGC 227
Query: 773 NTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGT 952
++Y + N ++IMAEIYKNGPVE +FTVY DF YKSGVY+H+TG +GGHA++++GWG
Sbjct: 228 SSYSISRNEKEIMAEIYKNGPVEGAFTVYSDFLQYKSGVYQHVTGDLMGGHAIRILGWGV 287
Query: 953 KN 958
+N
Sbjct: 288 EN 289
>sp|Q06544|CYSP3_OSTOS Cathepsin B-like cysteine proteinase 3 (Fragment)
OS=Ostertagia ostertagi GN=CP-3 PE=3 SV=1
Length = 174
Score = 112 bits (278), Expect = 8e-024
Identities = 58/130 (44%), Positives = 74/130 (56%), Gaps = 14/130 (10%)
Frame = +2
Query: 602 AWQYFSYSGVVT------EECDPYFDQTGCSHPGCEPAY-------NTPQCLRKCV-GRN 739
AWQYF+ GVVT + C ++ C G EP Y TP+C + C G
Sbjct: 1 AWQYFALEGVVTGGNYRKQGCCRPYEFPPCGRHGKEPYYGECYDTAKTPKCQKTCQRGYL 60
Query: 740 QLWSESKHYSVNTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIG 919
+ + E KH+ + Y + +N + I +I KNGPV F VYEDFAHYKSG+YKH G G
Sbjct: 61 KAYKEDKHFGKSAYRLPNNVKAIQRDIMKNGPVVAGFIVYEDFAHYKSGIYKHTAGRMTG 120
Query: 920 GHAVKLIGWG 949
GHAVK+IGWG
Sbjct: 121 GHAVKIIGWG 130
>sp|P07688|CATB_BOVIN Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5
Length = 335
Score = 111 bits (276), Expect = 1e-023
Identities = 52/122 (42%), Positives = 76/122 (62%), Gaps = 1/122 (0%)
Frame = +2
Query: 596 ISAWQYFSYSGVVTEECDPYFDQTGCSHPGCEPAYNTPQCLRKC-VGRNQLWSESKHYSV 772
+S Y S+ G P S P C +TP+C + C G + + E KH+
Sbjct: 168 VSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGC 227
Query: 773 NTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGT 952
++Y V +N ++IMAEIYKNGPVE +F+VY DF YKSGVY+H++G +GGHA++++GWG
Sbjct: 228 SSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGV 287
Query: 953 KN 958
+N
Sbjct: 288 EN 289
>sp|P43233|CATB_CHICK Cathepsin B OS=Gallus gallus GN=CTSB PE=2 SV=1
Length = 340
Score = 111 bits (276), Expect = 1e-023
Identities = 54/123 (43%), Positives = 74/123 (60%), Gaps = 2/123 (1%)
Frame = +2
Query: 596 ISAWQYFSYSGVVTEECDPYFDQTGCSHPGCE-PAYNTPQCLRKC-VGRNQLWSESKHYS 769
+S Y S+ G P S P C TP+C R C G + + E KHY
Sbjct: 168 VSGGLYDSHVGCRAYTIPPCEHHVNGSRPPCTGEGGETPRCSRHCEPGYSPSYKEDKHYG 227
Query: 770 VNTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWG 949
+ +Y V + ++IMAEIYKNGPVE +F VYEDF YKSGVY+H++G +GGHA++++GWG
Sbjct: 228 ITSYGVPRSEKEIMAEIYKNGPVEGAFIVYEDFLMYKSGVYQHVSGEQVGGHAIRILGWG 287
Query: 950 TKN 958
+N
Sbjct: 288 VEN 290
>sp|P00787|CATB_RAT Cathepsin B OS=Rattus norvegicus GN=Ctsb PE=1 SV=2
Length = 339
Score = 111 bits (275), Expect = 2e-023
Identities = 53/122 (43%), Positives = 73/122 (59%), Gaps = 1/122 (0%)
Frame = +2
Query: 596 ISAWQYFSYSGVVTEECDPYFDQTGCSHPGCEPAYNTPQCLRKC-VGRNQLWSESKHYSV 772
+S Y S+ G + P S P C +TP+C + C G + + E KHY
Sbjct: 168 VSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGY 227
Query: 773 NTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGT 952
+Y V + ++IMAEIYKNGPVE +FTV+ DF YKSGVYKH G +GGHA++++GWG
Sbjct: 228 TSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGI 287
Query: 953 KN 958
+N
Sbjct: 288 EN 289
>sp|P10605|CATB_MOUSE Cathepsin B OS=Mus musculus GN=Ctsb PE=1 SV=2
Length = 339
Score = 110 bits (274), Expect = 2e-023
Identities = 52/122 (42%), Positives = 74/122 (60%), Gaps = 1/122 (0%)
Frame = +2
Query: 596 ISAWQYFSYSGVVTEECDPYFDQTGCSHPGCEPAYNTPQCLRKC-VGRNQLWSESKHYSV 772
+S Y S+ G + P S P C +TP+C + C G + + E KH+
Sbjct: 168 VSGGVYNSHVGCLPYTIPPCEHHVNGSRPPCTGEGDTPRCNKSCEAGYSPSYKEDKHFGY 227
Query: 773 NTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGT 952
+Y V ++ ++IMAEIYKNGPVE +FTV+ DF YKSGVYKH G +GGHA++++GWG
Sbjct: 228 TSYSVSNSVKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDMMGGHAIRILGWGV 287
Query: 953 KN 958
+N
Sbjct: 288 EN 289
>sp|P43508|CPR4_CAEEL Cathepsin B-like cysteine proteinase 4 OS=Caenorhabditis
elegans GN=cpr-4 PE=2 SV=1
Length = 335
Score = 102 bits (254), Expect = 5e-021
Identities = 45/96 (46%), Positives = 60/96 (62%), Gaps = 3/96 (3%)
Frame = +2
Query: 680 PGC-EPAYNTPQCLRKCVGRNQ--LWSESKHYSVNTYVVESNPQDIMAEIYKNGPVEVSF 850
P C + Y+TP C+ KC +N ++ KH+ Y V I AEI +GPVE +F
Sbjct: 197 PSCPDDGYDTPACVNKCTNKNYNVAYTADKHFGSTAYAVGKKVSQIQAEIIAHGPVEAAF 256
Query: 851 TVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGTKN 958
TVYEDF YK+GVY H TG +GGHA++++GWGT N
Sbjct: 257 TVYEDFYQYKTGVYVHTTGQELGGHAIRILGWGTDN 292
>sp|P25793|CYSP2_HAECO Cathepsin B-like cysteine proteinase 2 OS=Haemonchus
contortus GN=AC-2 PE=2 SV=1
Length = 342
Score = 98 bits (242), Expect = 1e-019
Identities = 46/92 (50%), Positives = 58/92 (63%), Gaps = 1/92 (1%)
Frame = +2
Query: 686 CEPAYNTPQCLRKC-VGRNQLWSESKHYSVNTYVVESNPQDIMAEIYKNGPVEVSFTVYE 862
C TP C RKC G +++ K Y + Y+V+ + + I +EI KNGPV SF VYE
Sbjct: 205 CRGTAPTPPCKRKCRPGVRKMYRIDKRYGKDAYIVKQSVKAIQSEILKNGPVVASFAVYE 264
Query: 863 DFAHYKSGVYKHITGSNIGGHAVKLIGWGTKN 958
DF HYKSG+YKH G G HAVK+IGWG +N
Sbjct: 265 DFRHYKSGIYKHTAGELRGYHAVKMIGWGNEN 296
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 OS=Caenorhabditis
elegans GN=cpr-5 PE=1 SV=1
Length = 344
Score = 97 bits (239), Expect = 3e-019
Identities = 44/101 (43%), Positives = 59/101 (58%), Gaps = 4/101 (3%)
Frame = +2
Query: 668 GCSHPGC-EPAYNTPQCLRKCVGRNQL---WSESKHYSVNTYVVESNPQDIMAEIYKNGP 835
G P C E TP+C+ C +N + + KH+ Y V + I EI NGP
Sbjct: 197 GVKWPACPEDTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEILTNGP 256
Query: 836 VEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGTKN 958
+EV+FTVYEDF Y +GVY H G+++GGHAVK++GWG N
Sbjct: 257 IEVAFTVYEDFYQYTTGVYVHTAGASLGGHAVKILGWGVDN 297
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,894,514,945
Number of Sequences: 518415
Number of Extensions: 45894514945
Number of Successful Extensions: 338263929
Number of sequences better than 0.0: 0
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