BLASTX 7.6.2
Query= UN11739 /QuerySize=1160
(1159 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P54873|HMCS_ARATH Hydroxymethylglutaryl-CoA synthase OS=Arabi... 322 5e-087
sp|P54872|HMCSA_DICDI Hydroxymethylglutaryl-CoA synthase A OS=Di... 182 5e-045
sp|P54961|HMCS1_BLAGE Hydroxymethylglutaryl-CoA synthase 1 OS=Bl... 166 3e-040
sp|Q86HL5|HMCSB_DICDI Hydroxymethylglutaryl-CoA synthase B OS=Di... 164 1e-039
sp|Q01581|HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthase, cytopl... 162 5e-039
sp|Q5R7Z9|HMCS1_PONAB Hydroxymethylglutaryl-CoA synthase, cytopl... 162 5e-039
sp|P54870|HMCS2_BLAGE Hydroxymethylglutaryl-CoA synthase 2 OS=Bl... 159 4e-038
sp|P54868|HMCS2_HUMAN Hydroxymethylglutaryl-CoA synthase, mitoch... 158 7e-038
sp|Q8JZK9|HMCS1_MOUSE Hydroxymethylglutaryl-CoA synthase, cytopl... 156 5e-037
sp|P17425|HMCS1_RAT Hydroxymethylglutaryl-CoA synthase, cytoplas... 156 5e-037
sp|P23228|HMCS1_CHICK Hydroxymethylglutaryl-CoA synthase, cytopl... 155 6e-037
sp|P54869|HMCS2_MOUSE Hydroxymethylglutaryl-CoA synthase, mitoch... 153 2e-036
sp|P22791|HMCS2_RAT Hydroxymethylglutaryl-CoA synthase, mitochon... 153 4e-036
sp|P13704|HMCS1_CRIGR Hydroxymethylglutaryl-CoA synthase, cytopl... 151 1e-035
sp|Q2KIE6|HMCS2_BOVIN Hydroxymethylglutaryl-CoA synthase, mitoch... 150 2e-035
sp|O02734|HMCS2_PIG Hydroxymethylglutaryl-CoA synthase, mitochon... 149 4e-035
sp|P54874|HMCS_SCHPO Hydroxymethylglutaryl-CoA synthase OS=Schiz... 129 5e-029
sp|P54839|HMCS_YEAST Hydroxymethylglutaryl-CoA synthase OS=Sacch... 88 9e-017
>sp|P54873|HMCS_ARATH Hydroxymethylglutaryl-CoA synthase OS=Arabidopsis thaliana
GN=HMGS PE=2 SV=2
Length = 461
Score = 322 bits (823), Expect = 5e-087
Identities = 155/169 (91%), Positives = 164/169 (97%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GGAAAIAMLIGPDAPIVFESKLR SHMAHVYDFYKPNLASEYPVVDGKLSQTCYL+ALD
Sbjct: 159 TGGAAAIAMLIGPDAPIVFESKLRASHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALD 218
Query: 259 SCYKHLCNKFEKLEGKEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYLDVAAK 438
SCYKHLCNKFEK+EGKEFSINDADY VFHSPYNKLVQKSFARLLYNDFLRNAS +D AAK
Sbjct: 219 SCYKHLCNKFEKIEGKEFSINDADYIVFHSPYNKLVQKSFARLLYNDFLRNASSIDEAAK 278
Query: 439 EKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
EKFTPYSSL+LDESYQSRDLEKVSQQ+AK +YDAKVQPTTL+PKEVGN+
Sbjct: 279 EKFTPYSSLTLDESYQSRDLEKVSQQIAKPFYDAKVQPTTLIPKEVGNM 327
Score = 247 bits (630), Expect = 1e-064
Identities = 121/140 (86%), Positives = 130/140 (92%)
Frame = +3
Query: 567 KRSG*HYTASLYAAFASLIHNKHSDLVGKGVVMFSYGSGSTATMFSLRLCENHSPFSLSN 746
K G YTASLYAAFASLIH KH+DL GK VVMFSYGSGSTATMFSLRL +N PFS+SN
Sbjct: 322 KEVGNMYTASLYAAFASLIHKKHNDLAGKRVVMFSYGSGSTATMFSLRLNDNKPPFSISN 381
Query: 747 IASVMDVGGKLKARHEYAPEKFVETMKLMEHRYGAKEFVTSKEGILELLAPGTYYLKEVD 926
IASVMDVGGKLKARHEYAPEKFVETMKLMEHRYGAK+FVT+KEGI++LLAPGTYYLKEVD
Sbjct: 382 IASVMDVGGKLKARHEYAPEKFVETMKLMEHRYGAKDFVTTKEGIIDLLAPGTYYLKEVD 441
Query: 927 SLYRRFYGKKGDDGSIANGH 986
SLYRRFYGKKG+DGS+ANGH
Sbjct: 442 SLYRRFYGKKGEDGSVANGH 461
>sp|P54872|HMCSA_DICDI Hydroxymethylglutaryl-CoA synthase A OS=Dictyostelium
discoideum GN=hgsA PE=1 SV=2
Length = 482
Score = 182 bits (461), Expect = 5e-045
Identities = 90/168 (53%), Positives = 115/168 (68%), Gaps = 3/168 (1%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GGA +AMLIGP+API FES LRG HM +VYDFYKP++ SEYP VDGKLS +CY A+D
Sbjct: 161 TGGAGVVAMLIGPNAPITFESGLRGVHMENVYDFYKPDMDSEYPRVDGKLSISCYFRAID 220
Query: 259 SCYKHLCNKFEKLEGKEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYLDVAAK 438
+CY FEK GK FS++ D+ +FHSPYNKLVQKSF R+LYNDFL N + A+
Sbjct: 221 NCYNRYAKAFEKKYGKSFSLDQVDFALFHSPYNKLVQKSFGRMLYNDFLNNPNDSRYASL 280
Query: 439 EKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGN 582
E Y ++ +++Y LEK + K Y KV PTTL+ K++GN
Sbjct: 281 E---AYKNVKPEDTYFDSVLEKALSAITKNDYATKVAPTTLLAKQLGN 325
>sp|P54961|HMCS1_BLAGE Hydroxymethylglutaryl-CoA synthase 1 OS=Blattella
germanica GN=HMGCS-1 PE=2 SV=1
Length = 453
Score = 166 bits (419), Expect = 3e-040
Identities = 83/175 (47%), Positives = 117/175 (66%), Gaps = 12/175 (6%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GGA A+AML+G +AP+VF+ +R SHM H YDFYKP+L+S YP VDGKLS CYL ALD
Sbjct: 158 TGGAGAVAMLVGANAPLVFDRGVRSSHMQHAYDFYKPDLSSLYPTVDGKLSIQCYLSALD 217
Query: 259 SCYKHLCNKFEKLEGKEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYLDVAAK 438
CY+ C+K +K G++F I D +FH+PY KLVQKS ARL+ NDF+R + +
Sbjct: 218 HCYQLYCSKIQKQLGEKFDIERLDAVLFHAPYCKLVQKSLARLVLNDFVR------ASEE 271
Query: 439 EKFTPYSSL------SLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
E+ T YSSL L+++Y R++EK +K ++ K +P+ L+ +VGN+
Sbjct: 272 ERTTKYSSLEALKGVKLEDTYFDREVEKAVMTYSKNMFEEKTKPSLLLANQVGNM 326
>sp|Q86HL5|HMCSB_DICDI Hydroxymethylglutaryl-CoA synthase B OS=Dictyostelium
discoideum GN=hgsB PE=3 SV=1
Length = 468
Score = 164 bits (415), Expect = 1e-039
Identities = 83/170 (48%), Positives = 116/170 (68%), Gaps = 5/170 (2%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GGA + MLIGP+A ++F+ LRG+HM +V DFYKP+L+SEYP VDGKLS CYL ALD
Sbjct: 161 TGGAGVVTMLIGPNATLIFDQSLRGTHMENVNDFYKPDLSSEYPYVDGKLSIECYLRALD 220
Query: 259 SCYKHLCNKFEKL-EGKEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYLDVAA 435
CY KFE + + +FS++ DY FHSPYN+LVQKS+ARL+YNDFL+N +
Sbjct: 221 KCYLEYKKKFESINDDNKFSMDSFDYVCFHSPYNRLVQKSYARLIYNDFLQNPNN---PK 277
Query: 436 KEKFTPYSSLSL-DESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGN 582
+ P+ LS +SY + L++++ +L+ + KV P+TL+ KE GN
Sbjct: 278 YQDLLPFKDLSTGKDSYINSKLDQITLKLSLDDFKTKVNPSTLLSKECGN 327
>sp|Q01581|HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Homo
sapiens GN=HMGCS1 PE=1 SV=2
Length = 520
Score = 162 bits (409), Expect = 5e-039
Identities = 79/174 (45%), Positives = 112/174 (64%), Gaps = 5/174 (2%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GG A+A+LIGP+AP++FE LRG+HM H YDFYKP++ SEYP+VDGKLS CYL ALD
Sbjct: 171 TGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALD 230
Query: 259 SCYKHLCNKFE---KLEG--KEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYL 423
CY C K + EG K+F++ND + +FHSPY KLVQKS AR+L NDFL + +
Sbjct: 231 RCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRD 290
Query: 424 DVAAKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
+ + + L+++Y RD+EK + + + K + + LV + GN+
Sbjct: 291 KNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNM 344
>sp|Q5R7Z9|HMCS1_PONAB Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Pongo
abelii GN=HMGCS1 PE=2 SV=1
Length = 520
Score = 162 bits (409), Expect = 5e-039
Identities = 79/174 (45%), Positives = 112/174 (64%), Gaps = 5/174 (2%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GG A+A+LIGP+AP++FE LRG+HM H YDFYKP++ SEYP+VDGKLS CYL ALD
Sbjct: 171 TGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALD 230
Query: 259 SCYKHLCNKFE---KLEG--KEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYL 423
CY C K + EG K+F++ND + +FHSPY KLVQKS AR+L NDFL + +
Sbjct: 231 RCYSVYCKKIRAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRD 290
Query: 424 DVAAKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
+ + + L+++Y RD+EK + + + K + + LV + GN+
Sbjct: 291 KNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNM 344
>sp|P54870|HMCS2_BLAGE Hydroxymethylglutaryl-CoA synthase 2 OS=Blattella
germanica GN=HMGCS-2 PE=2 SV=1
Length = 455
Score = 159 bits (401), Expect = 4e-038
Identities = 87/178 (48%), Positives = 114/178 (64%), Gaps = 13/178 (7%)
Frame = +1
Query: 73 SLSGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIA 252
S +GGA A+ MLIG +APIV + +R SHM H YDFYKP+L SEYPVVDGKLS CYL A
Sbjct: 159 SPTGGAGALLMLIGANAPIVIDRGVRASHMKHAYDFYKPDLMSEYPVVDGKLSVQCYLSA 218
Query: 253 LDSCYKHLCNKFEKLE---GKEFSINDADY---FVFHSPYNKLVQKSFARLLYNDFLR-N 411
LD CY C+K EK GKE + D DY FVFHSPY KLVQKS ARL+ NDF++
Sbjct: 219 LDHCYPRFCSKTEKYLKRCGKENTKIDLDYFDAFVFHSPYCKLVQKSVARLVLNDFIQYP 278
Query: 412 ASYLDVAAKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
Y D+ +L +++Y RD+EK+ +K ++ K +P+ ++ +VGN+
Sbjct: 279 EKYQDL------QQLRNLKFEDTYFDRDIEKIFMDKSKQLFEKKTKPSLMLANQVGNM 330
>sp|P54868|HMCS2_HUMAN Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Homo
sapiens GN=HMGCS2 PE=1 SV=1
Length = 508
Score = 158 bits (399), Expect = 7e-038
Identities = 77/174 (44%), Positives = 116/174 (66%), Gaps = 5/174 (2%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GGA A+AMLIGP AP+ E LRG+HM +VYDFYKPNLASEYP+VDGKLS CYL ALD
Sbjct: 208 TGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALD 267
Query: 259 SCY----KHLCNKFEKL-EGKEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYL 423
CY K + N++++ + F+++D Y +FH+P+ K+VQKS ARL++NDFL +S
Sbjct: 268 RCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDT 327
Query: 424 DVAAKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
+ + + L L+++Y ++DL+K + ++ +D K + + + GN+
Sbjct: 328 QTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNM 381
>sp|Q8JZK9|HMCS1_MOUSE Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Mus
musculus GN=Hmgcs1 PE=1 SV=1
Length = 520
Score = 156 bits (392), Expect = 5e-037
Identities = 77/174 (44%), Positives = 111/174 (63%), Gaps = 5/174 (2%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GG A+A+LIGP+AP++F+ LRG+HM H YDFYKP++ SEYPVVDGKLS CYL ALD
Sbjct: 171 TGGVGAVALLIGPNAPLIFDRGLRGTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALD 230
Query: 259 SCYKHLCNKFE---KLEG--KEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYL 423
CY K + EG K+F++ND + +FHSPY KLVQKS AR+ NDFL + +
Sbjct: 231 RCYSVYRKKIRAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQNRD 290
Query: 424 DVAAKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
+ + + L+++Y RD+EK + + ++ K + + LV + GN+
Sbjct: 291 KNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFNQKTKASLLVSNQNGNM 344
>sp|P17425|HMCS1_RAT Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Rattus
norvegicus GN=Hmgcs1 PE=1 SV=1
Length = 520
Score = 156 bits (392), Expect = 5e-037
Identities = 77/174 (44%), Positives = 111/174 (63%), Gaps = 5/174 (2%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GG A+A+LIGP+AP++F+ LRG+HM H YDFYKP++ SEYPVVDGKLS CYL ALD
Sbjct: 171 TGGVGAVALLIGPNAPVIFDRGLRGTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALD 230
Query: 259 SCYKHLCNKFE---KLEG--KEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYL 423
CY K + EG K+F++ND + +FHSPY KLVQKS AR+ NDFL + +
Sbjct: 231 RCYSVYRKKIRAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQNRD 290
Query: 424 DVAAKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
+ + + L+++Y RD+EK + + ++ K + + LV + GN+
Sbjct: 291 KNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASAELFNQKTKASLLVSNQNGNM 344
>sp|P23228|HMCS1_CHICK Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Gallus
gallus GN=HMGCS1 PE=1 SV=1
Length = 522
Score = 155 bits (391), Expect = 6e-037
Identities = 82/176 (46%), Positives = 111/176 (63%), Gaps = 8/176 (4%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GGA A+AML+G +AP++FE LRG+HM H YDFYKP++ SEYPVVDGKLS CYL ALD
Sbjct: 171 TGGAGAVAMLVGSNAPLIFERGLRGTHMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALD 230
Query: 259 SCYKHLCNKFEKLEGKE-----FSINDADYFVFHSPYNKLVQKSFARLLYNDFL--RNAS 417
CY NK KE F++ND + +FHSPY KLVQKS ARLL NDFL +NA
Sbjct: 231 RCYSVYRNKIHAQWQKEGTDRGFTLNDFGFMIFHSPYCKLVQKSVARLLLNDFLSDQNAE 290
Query: 418 YLDVAAKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
+ + + L+++Y RD+EK + + ++ K + + LV + GN+
Sbjct: 291 TAN-GVFSGLEAFRDVKLEDTYFDRDVEKAFMKASAELFNQKTKASLLVSNQNGNM 345
>sp|P54869|HMCS2_MOUSE Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Mus
musculus GN=Hmgcs2 PE=1 SV=2
Length = 508
Score = 153 bits (386), Expect = 2e-036
Identities = 76/174 (43%), Positives = 115/174 (66%), Gaps = 5/174 (2%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GGA A+AMLIGP AP+V E LRG+HM + YDFYKPNLASEYP+VDGKLS CYL ALD
Sbjct: 208 TGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALD 267
Query: 259 SCY----KHLCNKFEKL-EGKEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYL 423
CY K + N++++ + F+++D Y +FH+P+ K+VQKS ARL++NDFL ++S
Sbjct: 268 RCYAAYRKKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDK 327
Query: 424 DVAAKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
+ + L L+E+Y ++D++K + + ++ K + + + GN+
Sbjct: 328 QNNLYKGLEAFRGLKLEETYTNKDVDKALLKASLDMFNQKTKASLYLSTNNGNM 381
>sp|P22791|HMCS2_RAT Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Rattus
norvegicus GN=Hmgcs2 PE=2 SV=1
Length = 508
Score = 153 bits (384), Expect = 4e-036
Identities = 75/174 (43%), Positives = 110/174 (63%), Gaps = 5/174 (2%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GGA A+AMLIGP AP+V E LRG+HM + YDFYKPNLASEYP+VDGKLS CYL ALD
Sbjct: 208 TGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALD 267
Query: 259 SCYKHLCNKFEKL-----EGKEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYL 423
CY K + + F+++D Y +FH+P+ K+VQKS ARL++NDFL ++S
Sbjct: 268 RCYAAYRRKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDK 327
Query: 424 DVAAKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
+ + L L+E+Y ++D++K + + ++ K + + + GN+
Sbjct: 328 QNNLYKGLEAFKGLKLEETYTNKDVDKALLKASLDMFNKKTKASLYLSTNNGNM 381
>sp|P13704|HMCS1_CRIGR Hydroxymethylglutaryl-CoA synthase, cytoplasmic
OS=Cricetulus griseus GN=HMGCS1 PE=3 SV=1
Length = 520
Score = 151 bits (379), Expect = 1e-035
Identities = 74/174 (42%), Positives = 107/174 (61%), Gaps = 5/174 (2%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GG A+A+LIGP+AP++F+ LRG+HM H YDFYKP++ SEYP+VDGKLS CYL ALD
Sbjct: 171 TGGVGAVALLIGPNAPLIFDRGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALD 230
Query: 259 SCYKHLCNKFEKLEGKE-----FSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYL 423
CY K KE F++ND + + HSPY KLVQKS AR+ NDFL + +
Sbjct: 231 RCYSVYRKKIRAQWQKEGNDNDFTLNDFGFMISHSPYCKLVQKSLARMFLNDFLNDQNRD 290
Query: 424 DVAAKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
+ + + L+++Y RD+EK + + ++ K + + LV + GN+
Sbjct: 291 KNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFNQKTKASLLVSNQNGNM 344
>sp|Q2KIE6|HMCS2_BOVIN Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Bos
taurus GN=HMGCS2 PE=2 SV=1
Length = 508
Score = 150 bits (378), Expect = 2e-035
Identities = 73/174 (41%), Positives = 110/174 (63%), Gaps = 5/174 (2%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GGA A+AML+GP+AP+V E LRG+HM +VYDFYKP++ SEYP+VDGKLS CYL ALD
Sbjct: 208 TGGAGAVAMLVGPEAPLVLERGLRGTHMENVYDFYKPDVTSEYPLVDGKLSIQCYLRALD 267
Query: 259 SCYKHLCNKFEKL-----EGKEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYL 423
CY K EK + F+++D Y +FH+P+ KLVQKS ARL++NDFL +
Sbjct: 268 KCYAFYRQKIEKQWKQAGIDRPFTLDDVQYMIFHTPFCKLVQKSLARLMFNDFLLASGDT 327
Query: 424 DVAAKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
+ + L L+++Y ++D++K + + ++ K + + + GN+
Sbjct: 328 QTGIYKGLEAFRGLKLEDTYTNKDVDKAFLKASLNMFNKKTKNSLYLSTYNGNM 381
>sp|O02734|HMCS2_PIG Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Sus
scrofa GN=HMGCS2 PE=2 SV=1
Length = 508
Score = 149 bits (375), Expect = 4e-035
Identities = 74/175 (42%), Positives = 111/175 (63%), Gaps = 7/175 (4%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GGA A+AML+GP+AP+ E LRG+HM + YDFYKPN SEYP+VDGKLS CYL ALD
Sbjct: 208 TGGAGAVAMLVGPEAPLALERGLRGTHMENAYDFYKPNATSEYPLVDGKLSIQCYLRALD 267
Query: 259 SCYKHLCNKFEK------LEGKEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASY 420
CY K EK +E + F+++D + +FH+P+ KLVQKS ARL+++DFL S
Sbjct: 268 RCYTLYRQKIEKQWKQAGIE-RHFTLDDLQFMIFHTPFCKLVQKSLARLMFSDFLLADSD 326
Query: 421 LDVAAKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
+ + + L+++Y ++D+EK Q+ + ++ K +P+ + GN+
Sbjct: 327 TQSSLYKGLEAFRGQKLEDTYANKDIEKAFQKASLDLFNKKTKPSLYLSLHNGNM 381
>sp|P54874|HMCS_SCHPO Hydroxymethylglutaryl-CoA synthase OS=Schizosaccharomyces
pombe GN=hcs1 PE=1 SV=1
Length = 447
Score = 129 bits (323), Expect = 5e-029
Identities = 69/171 (40%), Positives = 98/171 (57%), Gaps = 4/171 (2%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GGA +A+L+GP+APIVFE LRG++M H YDFYKP+L SEYP VDG S CY+ ALD
Sbjct: 160 TGGAGCVALLVGPNAPIVFEPGLRGTYMQHAYDFYKPDLTSEYPYVDGHFSLECYVKALD 219
Query: 259 SCYKHLCNKFEKLEGKE--FSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASYLDVA 432
Y + + GK ++ DY +FH+P K VQK++ARLLY D S ++
Sbjct: 220 GAYANYNVRDVAKNGKSQGLGLDRFDYCIFHAPTCKQVQKAYARLLYTDSAAEPSNPELE 279
Query: 433 AKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKEVGNI 585
+ S+L +S + LEK + K ++ +V P+ P GN+
Sbjct: 280 GVREL--LSTLDAKKSLTDKALEKGLMAITKERFNKRVSPSVYAPTNCGNM 328
>sp|P54839|HMCS_YEAST Hydroxymethylglutaryl-CoA synthase OS=Saccharomyces
cerevisiae GN=ERG13 PE=1 SV=1
Length = 491
Score = 88 bits (217), Expect = 9e-017
Identities = 42/69 (60%), Positives = 49/69 (71%), Gaps = 1/69 (1%)
Frame = +1
Query: 79 SGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLIALD 258
+GGA +AM IGPDAPIVF+S +R S+M H YDFYKP+ SEYP VDG S TCY+ ALD
Sbjct: 201 TGGAGTVAMWIGPDAPIVFDS-VRASYMEHAYDFYKPDFTSEYPYVDGHFSLTCYVKALD 259
Query: 259 SCYKHLCNK 285
YK K
Sbjct: 260 QVYKSYSKK 268
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,851,905,190
Number of Sequences: 518415
Number of Extensions: 48851905190
Number of Successful Extensions: 346316827
Number of sequences better than 0.0: 0
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