BLASTX 7.6.2
Query= UN11984 /QuerySize=1121
(1120 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O35130|NEP1_MOUSE Probable ribosome biogenesis protein NEP1 O... 215 6e-055
sp|Q92979|NEP1_HUMAN Probable ribosome biogenesis protein NEP1 O... 214 1e-054
sp|Q9W4J5|NEP1_DROME Probable ribosome biogenesis protein NEP1 O... 208 6e-053
sp|Q9P8P7|NEP1_CANAL Nucleolar essential protein 1 OS=Candida al... 203 3e-051
sp|Q06287|EMG1_YEAST Essential for mitotic growth 1 OS=Saccharom... 200 2e-050
sp|Q9XX15|NEP1_CAEEL Probable ribosome biogenesis protein nep-1 ... 194 1e-048
sp|Q10107|MRA1_SCHPO Multicopy suppressor of ras1 OS=Schizosacch... 191 1e-047
sp|Q96UP2|NEP1_CANGA Nucleolar essential protein 1 OS=Candida gl... 181 1e-044
>sp|O35130|NEP1_MOUSE Probable ribosome biogenesis protein NEP1 OS=Mus musculus
GN=Emg1 PE=1 SV=1
Length = 244
Score = 215 bits (546), Expect = 6e-055
Identities = 109/215 (50%), Positives = 148/215 (68%), Gaps = 4/215 (1%)
Frame = -1
Query: 832 SGNKKDQTGVIFVLEKASLEVAKVGKTYQLLNSDDHANFLRKNGRDPAHYRPDITHQALL 653
+G+K +I VLE ASLE KVGKTY+LLN D H + L KNGRDP RPDITHQ+LL
Sbjct: 34 AGSKCGGRRLIVVLEGASLETVKVGKTYELLNCDRHKSMLLKNGRDPGEVRPDITHQSLL 93
Query: 652 MILDSPVNKAGRLKAVYVRTEQGVLFEVKPHVRIPRTFKRFAGIMLQLLQKLSISASGKR 473
M++DSP+N+AG L+ VY+ T++ VL EV P RIPRTF RF G+M+QLL KLS+ A+
Sbjct: 94 MLMDSPLNRAGLLQ-VYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGP 152
Query: 472 EKLMRVIKNPVTSHLPPNCRKIGFSYSSEKLVNMQKHLSTVCNETDTVFVLGAMSHGKIE 293
+KL++VIKNPV+ H P C KIG S+S E + ++++ V + VFV+GA +HGK+
Sbjct: 153 QKLLKVIKNPVSDHFPVGCMKIGTSFSVEDISDIRE---LVPSSDPVVFVVGAFAHGKVS 209
Query: 292 CDYIDDFVAISGYPLSAAYCISRICEALSTNWNII 188
+Y + V+IS YPLSAA +++ A W +I
Sbjct: 210 VEYTEKMVSISNYPLSAALTCAKVTTAFEEVWGVI 244
>sp|Q92979|NEP1_HUMAN Probable ribosome biogenesis protein NEP1 OS=Homo sapiens
GN=EMG1 PE=1 SV=4
Length = 244
Score = 214 bits (543), Expect = 1e-054
Identities = 111/226 (49%), Positives = 151/226 (66%), Gaps = 4/226 (1%)
Frame = -1
Query: 865 DELDVGIPIVVSGNKKDQTGVIFVLEKASLEVAKVGKTYQLLNSDDHANFLRKNGRDPAH 686
D L P + +GNK +I VLE ASLE KVGKTY+LLN D H + L KNGRDP
Sbjct: 23 DALPPKRPRLGAGNKIGGRRLIVVLEGASLETVKVGKTYELLNCDKHKSILLKNGRDPGE 82
Query: 685 YRPDITHQALLMILDSPVNKAGRLKAVYVRTEQGVLFEVKPHVRIPRTFKRFAGIMLQLL 506
RPDITHQ+LLM++DSP+N+AG L+ VY+ T++ VL EV P RIPRTF RF G+M+QLL
Sbjct: 83 ARPDITHQSLLMLMDSPLNRAGLLQ-VYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLL 141
Query: 505 QKLSISASGKREKLMRVIKNPVTSHLPPNCRKIGFSYSSEKLVNMQKHLSTVCNETDTVF 326
KLS+ A+ +KL++VIKNPV+ H P C K+G S+S + ++++ V + VF
Sbjct: 142 HKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKVGTSFSIPVVSDVRE---LVPSSDPIVF 198
Query: 325 VLGAMSHGKIECDYIDDFVAISGYPLSAAYCISRICEALSTNWNII 188
V+GA +HGK+ +Y + V+IS YPLSAA +++ A W +I
Sbjct: 199 VVGAFAHGKVSVEYTEKMVSISNYPLSAALTCAKLTTAFEEVWGVI 244
>sp|Q9W4J5|NEP1_DROME Probable ribosome biogenesis protein NEP1 OS=Drosophila
melanogaster GN=CG3527 PE=3 SV=2
Length = 252
Score = 208 bits (529), Expect = 6e-053
Identities = 104/211 (49%), Positives = 138/211 (65%), Gaps = 6/211 (2%)
Frame = -1
Query: 805 VIFVLEKASLEVAKVGKTYQLLNSDDHANFLRKNGRDPAHYRPDITHQALLMILDSPVNK 626
+I VLE A LE KV T++LLN DDHA +RKN RDP RPDITHQ LLM+ DSP+N+
Sbjct: 43 LIIVLEGAQLETVKVHNTFELLNCDDHAGIMRKNQRDPGSCRPDITHQCLLMLFDSPLNR 102
Query: 625 AGRLKAVYVRTEQGVLFEVKPHVRIPRTFKRFAGIMLQLLQKLSISASGKREKLMRVIKN 446
AG L+ V+VRTE VL E+ P RIPRTFKRFAG+M+QLL K I A+ +LM VIKN
Sbjct: 103 AGLLQ-VFVRTEHNVLIEINPQTRIPRTFKRFAGLMVQLLHKFQIRANDSSRRLMSVIKN 161
Query: 445 PVTSHLPPNCRKIGFSYSSEKLVNMQKHL-----STVCNETDTVFVLGAMSHGKIECDYI 281
P+T H+P C+K S+S + L N + + ++ + V V+GA +HG ++ DY
Sbjct: 162 PITDHVPVGCKKYAMSFSGKLLPNCRDLVPHGDETSASYDEPVVIVIGAFAHGVLKTDYT 221
Query: 280 DDFVAISGYPLSAAYCISRICEALSTNWNII 188
++ +IS YPLSAA S+IC A W ++
Sbjct: 222 EELFSISNYPLSAAIACSKICSAFEEVWGVV 252
>sp|Q9P8P7|NEP1_CANAL Nucleolar essential protein 1 OS=Candida albicans GN=NEP1
PE=3 SV=1
Length = 267
Score = 203 bits (514), Expect = 3e-051
Identities = 118/268 (44%), Positives = 164/268 (61%), Gaps = 13/268 (4%)
Frame = -1
Query: 967 EQKRKEVKKAKREEATSNAEEEDDEENERAEEAADELDVGIPIVVSGNKKDQTGVIFVLE 788
E K + K E S+++ + N+ + A + V P ++ K +I VL
Sbjct: 3 ELKNGTTEPKKNETTQSDSKSKSTSTNKSSVPPASLVPVQ-PTALTSRDKTTQRLIVVLS 61
Query: 787 KASLEVAKV------GKTYQLLNSDDHANFLRKNGRDPAHYRPDITHQALLMILDSPVNK 626
+A LE K+ G + LLN DDH LRK GRD A RPDITHQ LL +LDSP+NK
Sbjct: 62 QACLETYKMNSGGPGGDRFALLNCDDHQGLLRKMGRDIAEARPDITHQCLLTLLDSPINK 121
Query: 625 AGRLKAVYVRTEQGVLFEVKPHVRIPRTFKRFAGIMLQLLQKLSISASGKREKLMRVIKN 446
AGRL+ VY++T +GVL EV P VRIPRTFKRF+G+M+QLL KLSI + +E L++VIKN
Sbjct: 122 AGRLQ-VYIQTARGVLIEVNPSVRIPRTFKRFSGLMVQLLHKLSIRSENSKEVLLKVIKN 180
Query: 445 PVTSHLPPNCRKIGFSYSSEKLVNMQKHLSTVC-NETDTVFVLGAMSHGK--IECDYIDD 275
P+T HLP CRK+ S+ +E L +Q +++T+ NE+ VFV GAM+ GK +++D+
Sbjct: 181 PITDHLPTKCRKVTLSFDAE-LKRVQDYVTTLDENESICVFV-GAMARGKDNFADEFVDE 238
Query: 274 FVAISGYPLSAAYCISRICEALSTNWNI 191
+ +S YPLSA+ S+ C W I
Sbjct: 239 KIGLSDYPLSASVACSKFCHGCEDVWGI 266
>sp|Q06287|EMG1_YEAST Essential for mitotic growth 1 OS=Saccharomyces cerevisiae
GN=EMG1 PE=1 SV=1
Length = 252
Score = 200 bits (508), Expect = 2e-050
Identities = 105/227 (46%), Positives = 146/227 (64%), Gaps = 10/227 (4%)
Frame = -1
Query: 844 PIVVSGNKKDQTGVIFVLEKASLEVAKV------GKTYQLLNSDDHANFLRKNGRDPAHY 683
P V++ K +I VL ASLE K+ G Y LLN DDH L+K GRD +
Sbjct: 28 PPVLTSKDKITKRMIVVLAMASLETHKISSNGPGGDKYVLLNCDDHQGLLKKMGRDISEA 87
Query: 682 RPDITHQALLMILDSPVNKAGRLKAVYVRTEQGVLFEVKPHVRIPRTFKRFAGIMLQLLQ 503
RPDITHQ LL +LDSP+NKAG+L+ VY++T +G+L EV P VRIPRTFKRF+G+M+QLL
Sbjct: 88 RPDITHQCLLTLLDSPINKAGKLQ-VYIQTSRGILIEVNPTVRIPRTFKRFSGLMVQLLH 146
Query: 502 KLSISASGKREKLMRVIKNPVTSHLPPNCRKIGFSYSSEKLVNMQKHLSTVCNETDTVFV 323
KLSI + EKL++VIKNP+T HLP CRK+ S+ + ++ +Q ++ + ++
Sbjct: 147 KLSIRSVNSEEKLLKVIKNPITDHLPTKCRKVTLSFDA-PVIRVQDYIEKLDDDESICVF 205
Query: 322 LGAMSHGK--IECDYIDDFVAISGYPLSAAYCISRICEALSTNWNII 188
+GAM+ GK +Y+D+ V +S YPLSA+ S+ C WNI+
Sbjct: 206 VGAMARGKDNFADEYVDEKVGLSNYPLSASVACSKFCHGAEDAWNIL 252
>sp|Q9XX15|NEP1_CAEEL Probable ribosome biogenesis protein nep-1
OS=Caenorhabditis elegans GN=Y39A1A.14 PE=2 SV=1
Length = 231
Score = 194 bits (491), Expect = 1e-048
Identities = 106/212 (50%), Positives = 138/212 (65%), Gaps = 6/212 (2%)
Frame = -1
Query: 820 KDQTGVIFVLEKASLEVAKVGKTYQLLNSDDHANFLRKNGRDPAHYRPDITHQALLMILD 641
+D+ + VLE SLE AKVG Y +L+SD HANFLRK +DPA YRPDI HQ LL +LD
Sbjct: 23 EDKKILYVVLEGCSLETAKVGGEYAILSSDKHANFLRKQKKDPADYRPDILHQCLLNLLD 82
Query: 640 SPVNKAGRLKAVYVRTEQGVLFEVKPHVRIPRTFKRFAGIMLQLLQKLSISASGKREKLM 461
SP+N+AG+L+ V+ RT + VL +V P RIPRTF RF G+M+QLL KLSI A+ +KLM
Sbjct: 83 SPLNRAGKLR-VFFRTSKNVLVDVSPQCRIPRTFDRFCGLMVQLLHKLSIRAAETTQKLM 141
Query: 460 RVIKNPVTSHLPPNCRKIGFSYSSEKLVNMQKHLSTVCNETD--TVFVLGAMSHGKIECD 287
V+KNPV++HLP RK+ S++ +L K V ETD V ++G ++ GKI D
Sbjct: 142 SVVKNPVSNHLPVGSRKMLMSFNVPELTMANK---LVAPETDEPLVLIIGGIARGKIVVD 198
Query: 286 YIDDFVAISGYPLSAAYCISRICEALSTNWNI 191
Y D IS YPLSAA +++ L W I
Sbjct: 199 YNDSETKISNYPLSAALTCAKVTSGLEEIWGI 230
>sp|Q10107|MRA1_SCHPO Multicopy suppressor of ras1 OS=Schizosaccharomyces pombe
GN=mra1 PE=1 SV=2
Length = 359
Score = 191 bits (483), Expect = 1e-047
Identities = 105/212 (49%), Positives = 141/212 (66%), Gaps = 8/212 (3%)
Frame = -1
Query: 805 VIFVLEKASLEVAKVGKT----YQLLNSDDHANFLRKNGRDPAHYRPDITHQALLMILDS 638
+I VL++A LE+ KVGK YQLLN DDH L+K R+ A RPDITHQ LL +LDS
Sbjct: 150 LIVVLDQACLEIYKVGKAKDAKYQLLNCDDHQGILKKLNRNIAQARPDITHQCLLTLLDS 209
Query: 637 PVNKAGRLKAVYVRTEQGVLFEVKPHVRIPRTFKRFAGIMLQLLQKLSISASGKREKLMR 458
P+NKAGRL+ VY+ T + VL EV P VRIPRTFKRF+G+M+QLL KLSI + EKL++
Sbjct: 210 PLNKAGRLQ-VYIHTAKKVLIEVNPSVRIPRTFKRFSGLMVQLLHKLSIRSVNGNEKLLK 268
Query: 457 VIKNPVTSHLPPNCRKIGFSYSSEKLVNMQKHLSTVCNETDTVFVLGAMSHGKIECD--Y 284
VIKNPVT +LPPNCRK S+ + V +K+L T+ +GAM+HG + +
Sbjct: 269 VIKNPVTDYLPPNCRKATLSFDA-PTVPPRKYLETLQPNQSVCIAIGAMAHGPDDFSDGW 327
Query: 283 IDDFVAISGYPLSAAYCISRICEALSTNWNII 188
+D+ ++IS YPLSA+ S+ ++ I+
Sbjct: 328 VDEKISISDYPLSASIACSKFLHSMEDFLGIV 359
>sp|Q96UP2|NEP1_CANGA Nucleolar essential protein 1 OS=Candida glabrata GN=NEP1
PE=3 SV=1
Length = 229
Score = 181 bits (457), Expect = 1e-044
Identities = 109/225 (48%), Positives = 141/225 (62%), Gaps = 9/225 (4%)
Frame = -1
Query: 853 VGIPIVVSGNKKDQTGVIFVLEKASLEV-AKVGKTYQLLNSDDHANFLRKNGRDPAHYRP 677
+G P S KK + + VL +ASLE LLN DDH LRK GRD A RP
Sbjct: 9 IGGPNNSSVTKKQEPRLYVVLCEASLETYTSNDHRTSLLNCDDHQGILRKMGRDIAEARP 68
Query: 676 DITHQALLMILDSPVNKAGRLKAVYVRTEQGVLFEVKPHVRIPRTFKRFAGIMLQLLQKL 497
DITHQ LL +LDSP+NKAG L+ VY+ T++ VL EV P VRIPRTFKRF+G+M+QLL KL
Sbjct: 69 DITHQCLLTLLDSPINKAGLLQ-VYILTKKNVLIEVNPSVRIPRTFKRFSGLMVQLLHKL 127
Query: 496 SI-SASGKREKLMRVIKNPVTSHLPPNCRKIGFSYSSEKLVNMQKHLSTVCNETDTVFVL 320
SI S L+RV+KNPVT +LP +CRK+ S+ +E ++ Q++L ++ VFV
Sbjct: 128 SIRSMESSNTHLLRVVKNPVTKYLPADCRKVTLSFDAE-VMRPQEYLGD--KQSVCVFV- 183
Query: 319 GAMS--HGKIECDYIDDFVAISGYPLSAAYCISRICEALSTNWNI 191
GAM+ H +Y+DD +AIS YPLSA+ S+ C W I
Sbjct: 184 GAMARGHDSFADEYVDDKIAISNYPLSASVACSKFCHGAEDAWAI 228
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,851,905,190
Number of Sequences: 518415
Number of Extensions: 48851905190
Number of Successful Extensions: 346316827
Number of sequences better than 0.0: 0
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