BLASTX 7.6.2
Query= UN12086 /QuerySize=964
(963 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9ASX2|TRNH1_ARATH Tropinone reductase homolog At1g07440 OS=A... 345 3e-094
sp|P50165|TRNH_DATST Tropinone reductase homolog OS=Datura stram... 308 4e-083
sp|P50162|TRN1_DATST Tropinone reductase 1 OS=Datura stramonium ... 300 9e-081
sp|P50164|TRN2_HYONI Tropinone reductase 2 OS=Hyoscyamus niger G... 288 6e-077
sp|P50163|TRN2_DATST Tropinone reductase 2 OS=Datura stramonium ... 282 3e-075
sp|Q9GKX2|DHRS4_RABIT Dehydrogenase/reductase SDR family member ... 164 8e-040
sp|Q8VID1|DHRS4_RAT Dehydrogenase/reductase SDR family member 4 ... 157 2e-037
sp|Q9X248|FABG_THEMA 3-oxoacyl-[acyl-carrier-protein] reductase ... 155 5e-037
sp|Q99LB2|DHRS4_MOUSE Dehydrogenase/reductase SDR family member ... 154 8e-037
sp|P50199|GNO_GLUOX Gluconate 5-dehydrogenase OS=Gluconobacter o... 154 1e-036
sp|Q9BTZ2|DHRS4_HUMAN Dehydrogenase/reductase SDR family member ... 153 2e-036
sp|Q5RCF8|DHRS4_PONAB Dehydrogenase/reductase SDR family member ... 153 2e-036
sp|Q8SPU8|DHRS4_BOVIN Dehydrogenase/reductase SDR family member ... 152 4e-036
sp|Q8WNV7|DHRS4_PIG Dehydrogenase/reductase SDR family member 4 ... 147 1e-034
sp|P0A9Q0|IDNO_ECOL6 Gluconate 5-dehydrogenase OS=Escherichia co... 131 9e-030
sp|P0A9P9|IDNO_ECOLI Gluconate 5-dehydrogenase OS=Escherichia co... 131 9e-030
sp|P0CG22|DR4L1_HUMAN Putative dehydrogenase/reductase SDR famil... 127 1e-028
sp|Q8KWT4|BACC2_BACSU Bacilysin biosynthesis oxidoreductase BacC... 127 1e-028
sp|P50842|KDUD_BACSU 2-dehydro-3-deoxy-D-gluconate 5-dehydrogena... 127 2e-028
sp|P39640|BACC_BACSU Bacilysin biosynthesis oxidoreductase BacC ... 125 7e-028
>sp|Q9ASX2|TRNH1_ARATH Tropinone reductase homolog At1g07440 OS=Arabidopsis
thaliana GN=At1g07440 PE=1 SV=1
Length = 266
Score = 345 bits (884), Expect = 3e-094
Identities = 170/259 (65%), Positives = 204/259 (78%), Gaps = 1/259 (0%)
Frame = +1
Query: 34 ENNKRWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLA 213
E ++RWSL KT LVTGGT+GIG A+VEE A FGA +HTC+RN+ EL CL W+ G
Sbjct: 5 EQSQRWSLKAKTVLVTGGTKGIGHAIVEEFAGFGAVIHTCARNEYELNECLSKWQKKGFQ 64
Query: 214 VTGSVCDASDRDQREKLIQEVSSAFSGKLNILINNVGTNIRKPTVEYTSEDYAKIMSINL 393
VTGSVCDAS R +REKL+Q VSS F GKL+ILINN+G KPT++YT+ED++ +S NL
Sbjct: 65 VTGSVCDASLRPEREKLMQTVSSMFGGKLDILINNLGAIRSKPTLDYTAEDFSFHISTNL 124
Query: 394 ESAFHFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAG 573
ESA+H SQ+AHPLLKASG G+I+F+SS+AG+V S GS+Y ATKGALNQL RNLACEWA
Sbjct: 125 ESAYHLSQLAHPLLKASGCGNIIFMSSIAGVVSASVGSIYSATKGALNQLARNLACEWAS 184
Query: 574 DNIRTNCVAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASY 753
D IR N VAP I T L + + + + F++ V+SR PLGR GEPEEVSSLVAFLC+PAASY
Sbjct: 185 DGIRANAVAPAVIATPLAEAVYDDE-FKKVVISRKPLGRFGEPEEVSSLVAFLCMPAASY 243
Query: 754 ITGQVISVDGGFTVNGFSY 810
ITGQ I VDGG TVNGFSY
Sbjct: 244 ITGQTICVDGGLTVNGFSY 262
>sp|P50165|TRNH_DATST Tropinone reductase homolog OS=Datura stramonium PE=2
SV=1
Length = 268
Score = 308 bits (788), Expect = 4e-083
Identities = 148/258 (57%), Positives = 193/258 (74%), Gaps = 3/258 (1%)
Frame = +1
Query: 40 NKRWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVT 219
++RWSL G TALVTGGTRGIG A+VEELA FGA V+TCSR+Q +L CL+ W+ G V+
Sbjct: 10 DRRWSLRGMTALVTGGTRGIGYAIVEELANFGAEVYTCSRSQNDLDECLEKWRRKGFKVS 69
Query: 220 GSVCDASDRDQREKLIQEVSSAFSGKLNILINNVGTNIRKPTVEYTSEDYAKIMSINLES 399
G VCD S QR+ L++ V+S+F+GKLNILINN GT I K +T+EDY+ IM N E+
Sbjct: 70 GPVCDVSSISQRQTLMESVTSSFNGKLNILINNAGTTIPKEATNFTAEDYSIIMGTNFEA 129
Query: 400 AFHFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDN 579
+++ Q+AHPLLKASG SIVF SS AG++ + S+Y A+KGA+NQ+T++LACEWA D+
Sbjct: 130 SYNLCQLAHPLLKASGNASIVFNSSAAGVIAVPLSSIYAASKGAINQVTKSLACEWAKDS 189
Query: 580 IRTNCVAPWYIKTSLVKPLLE---KKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAAS 750
IR N VAPW I T +++ + +K E+++ R P+ R GEP EVSSLV +LCLP AS
Sbjct: 190 IRVNAVAPWIINTPIIEAACQVPSQKKNIESLIGRAPMKRAGEPSEVSSLVTYLCLPTAS 249
Query: 751 YITGQVISVDGGFTVNGF 804
YITGQ+I VDGG+TVNGF
Sbjct: 250 YITGQIICVDGGYTVNGF 267
>sp|P50162|TRN1_DATST Tropinone reductase 1 OS=Datura stramonium GN=TR1 PE=1
SV=1
Length = 273
Score = 300 bits (768), Expect = 9e-081
Identities = 147/263 (55%), Positives = 191/263 (72%), Gaps = 4/263 (1%)
Frame = +1
Query: 25 LTMENNKRWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSN 204
+ N RWSL G TALVTGG++GIG A+VEELA GA V+TCSRN++EL CL+ W+
Sbjct: 9 MNCNNEGRWSLKGTTALVTGGSKGIGYAIVEELAGLGARVYTCSRNEKELDECLEIWREK 68
Query: 205 GLAVTGSVCDASDRDQREKLIQEVSSAFSGKLNILINNVGTNIRKPTVEYTSEDYAKIMS 384
GL V GSVCD R +R+KL+Q V+ F GKLNIL+NN G I K ++T +DY IM
Sbjct: 69 GLNVEGSVCDLLSRTERDKLMQTVAHVFDGKLNILVNNAGVVIHKEAKDFTEKDYNIIMG 128
Query: 385 INLESAFHFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACE 564
N E+A+H SQIA+PLLKAS G+++F+SS+AG L S S+Y A+KGA+NQ+T++LACE
Sbjct: 129 TNFEAAYHLSQIAYPLLKASQNGNVIFLSSIAGFSALPSVSLYSASKGAINQMTKSLACE 188
Query: 565 WAGDNIRTNCVAPWYIKTSLVKPLLEKKGFEEAVVS----RTPLGRVGEPEEVSSLVAFL 732
WA DNIR N VAP I T LV+ ++K ++ + +TP+GR G+P+EVS+L+AFL
Sbjct: 189 WAKDNIRVNSVAPGVILTPLVETAIKKNPHQKEEIDNFIVKTPMGRAGKPQEVSALIAFL 248
Query: 733 CLPAASYITGQVISVDGGFTVNG 801
C PAASYITGQ+I DGGFT NG
Sbjct: 249 CFPAASYITGQIIWADGGFTANG 271
>sp|P50164|TRN2_HYONI Tropinone reductase 2 OS=Hyoscyamus niger GN=TR2 PE=2
SV=1
Length = 260
Score = 288 bits (735), Expect = 6e-077
Identities = 146/255 (57%), Positives = 186/255 (72%), Gaps = 3/255 (1%)
Frame = +1
Query: 46 RWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTGS 225
RW+L G TALVTGG+RGIG +VEELA GA+V+TCSRNQ+EL CL W+S G V S
Sbjct: 4 RWNLEGCTALVTGGSRGIGYGIVEELANLGASVYTCSRNQKELDECLTQWRSKGFNVEAS 63
Query: 226 VCDASDRDQREKLIQEVSSAFSGKLNILINNVGTNIRKPTVEYTSEDYAKIMSINLESAF 405
VCD S R +RE+ ++ VS+ F GKLNIL+NN G I K +YT EDY+ IMSIN E+A+
Sbjct: 64 VCDLSSRSEREEFMKTVSNHFHGKLNILVNNAGIVIYKEAKDYTMEDYSHIMSINFEAAY 123
Query: 406 HFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDNIR 585
H S +AHP LKAS G++VFISS++G L +VYGATKGA++QLTR LA EWA DNIR
Sbjct: 124 HLSVLAHPFLKASERGNVVFISSISGASALPYEAVYGATKGAMDQLTRCLAFEWAKDNIR 183
Query: 586 TNCVAPWYIKTSLVKPLL---EKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASYI 756
N V P I TS+V+ + E+K + ++ R L R+GEP+E++++VAFLC PAASY+
Sbjct: 184 VNGVGPGVIATSMVEMTIQDPEQKENLDKLIDRCALRRMGEPKELAAVVAFLCFPAASYV 243
Query: 757 TGQVISVDGGFTVNG 801
TGQ+I VDGGF NG
Sbjct: 244 TGQIIYVDGGFMANG 258
>sp|P50163|TRN2_DATST Tropinone reductase 2 OS=Datura stramonium GN=TR2 PE=1
SV=1
Length = 260
Score = 282 bits (721), Expect = 3e-075
Identities = 144/254 (56%), Positives = 184/254 (72%), Gaps = 3/254 (1%)
Frame = +1
Query: 46 RWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTGS 225
RW+L G TALVTGG+RGIG +VEELA GA+V+TCSRNQ+EL CL W+S G V S
Sbjct: 4 RWNLEGCTALVTGGSRGIGYGIVEELASLGASVYTCSRNQKELNDCLTQWRSKGFKVEAS 63
Query: 226 VCDASDRDQREKLIQEVSSAFSGKLNILINNVGTNIRKPTVEYTSEDYAKIMSINLESAF 405
VCD S R +R++L+ V++ F GKLNIL+NN G I K +YT EDY+ IMSIN E+A+
Sbjct: 64 VCDLSSRSERQELMNTVANHFHGKLNILVNNAGIVIYKEAKDYTVEDYSLIMSINFEAAY 123
Query: 406 HFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDNIR 585
H S +AHP LKAS G++VFISSV+G + + +VYGATKGA++QLTR LA EWA DNIR
Sbjct: 124 HLSVLAHPFLKASERGNVVFISSVSGALAVPYEAVYGATKGAMDQLTRCLAFEWAKDNIR 183
Query: 586 TNCVAPWYIKTSLVKPLL---EKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASYI 756
N V P I TSLV+ + E+K ++ R L R+GEP+E++++VAFLC PAASY+
Sbjct: 184 VNGVGPGVIATSLVEMTIQDPEQKENLNKLIDRCALRRMGEPKELAAMVAFLCFPAASYV 243
Query: 757 TGQVISVDGGFTVN 798
TGQ+I VDGG N
Sbjct: 244 TGQIIYVDGGLMAN 257
>sp|Q9GKX2|DHRS4_RABIT Dehydrogenase/reductase SDR family member 4
OS=Oryctolagus cuniculus GN=DHRS4 PE=1 SV=1
Length = 260
Score = 164 bits (415), Expect = 8e-040
Identities = 95/249 (38%), Positives = 143/249 (57%), Gaps = 2/249 (0%)
Frame = +1
Query: 43 KRWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTG 222
+R LA K A+VT T GIG A+ LA+ GA V SR Q+ + + ++ GL+VTG
Sbjct: 8 RRDPLANKVAIVTASTDGIGLAIARRLAQDGAHVVISSRKQQNVDRAVAALQAEGLSVTG 67
Query: 223 SVCDASDRDQREKLIQEVSSAFSGKLNILINNVGTN-IRKPTVEYTSEDYAKIMSINLES 399
+VC + RE+L+ + G ++IL++N N ++ T E + KI+ IN+++
Sbjct: 68 TVCHVGKAEDRERLVATALNLHGG-IDILVSNAAVNPFFGKLMDVTEEVWDKILDINVKA 126
Query: 400 AFHFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDN 579
++ P ++ G GS+V ++S+A S Y +K AL LT+NLA E A N
Sbjct: 127 MALMTKAVVPEMEKRGGGSVVIVASIAAFNPFSGLGPYNVSKTALVGLTKNLALELAAQN 186
Query: 580 IRTNCVAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASYIT 759
IR NC+AP IKTS K L E K EE ++ + + R+G+PEE + +V+FLC ASYIT
Sbjct: 187 IRVNCLAPGLIKTSFSKALWEDKAQEENIIQKLRIRRLGKPEECAGIVSFLCSEDASYIT 246
Query: 760 GQVISVDGG 786
G+ + V GG
Sbjct: 247 GETVVVAGG 255
>sp|Q8VID1|DHRS4_RAT Dehydrogenase/reductase SDR family member 4 OS=Rattus
norvegicus GN=Dhrs4 PE=2 SV=1
Length = 260
Score = 157 bits (395), Expect = 2e-037
Identities = 94/245 (38%), Positives = 133/245 (54%), Gaps = 2/245 (0%)
Frame = +1
Query: 55 LAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTGSVCD 234
LA K ALVT T GIG A+ LA GA V SR Q+ + + + GL+VTG VC
Sbjct: 12 LANKVALVTASTDGIGLAIARRLAEDGAHVVISSRKQQNVDRAVATLQGEGLSVTGVVCH 71
Query: 235 ASDRDQREKLIQEVSSAFSGKLNILINNVGTN-IRKPTVEYTSEDYAKIMSINLESAFHF 411
+ REKL+ G ++IL++N N ++ T E + K++SIN+ ++
Sbjct: 72 VGKAEDREKLVNMALKLHQG-IDILVSNAAVNPFFGNLMDVTEEVWNKVLSINVTASAMM 130
Query: 412 SQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDNIRTN 591
+ P ++ G GS+V +SSVAG V S Y +K AL LT+N A E A NIR N
Sbjct: 131 IKAVVPAMEKRGGGSVVIVSSVAGFVLFPSLGPYNVSKTALLGLTKNFAAELAPKNIRVN 190
Query: 592 CVAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASYITGQVI 771
C+AP IKT L ++K EE + + R+G+PE+ +V+FLC ASYI G+ +
Sbjct: 191 CLAPGLIKTHFSSVLWKEKAREEMIKETMQIRRLGKPEDCVGIVSFLCSEDASYINGETV 250
Query: 772 SVDGG 786
V GG
Sbjct: 251 VVGGG 255
>sp|Q9X248|FABG_THEMA 3-oxoacyl-[acyl-carrier-protein] reductase OS=Thermotoga
maritima GN=fabG PE=3 SV=1
Length = 246
Score = 155 bits (391), Expect = 5e-037
Identities = 90/244 (36%), Positives = 141/244 (57%), Gaps = 3/244 (1%)
Frame = +1
Query: 55 LAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTGSVCD 234
L GK L+TG GIG+A A+ GATV ++E L S + + + V V +
Sbjct: 3 LEGKVCLITGAASGIGKATTLLFAQEGATVIAGDISKENLDSLVKEAEGLPGKVDPYVLN 62
Query: 235 ASDRDQREKLIQEVSSAFSGKLNILINNVGTNIRKPTVEYTSEDYAKIMSINLESAFHFS 414
+DRDQ ++++++V + G++++L+NN G V ED+ ++++NL+ F+ +
Sbjct: 63 VTDRDQIKEVVEKVVQKY-GRIDVLVNNAGITRDALLVRMKEEDWDAVINVNLKGVFNVT 121
Query: 415 QIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDNIRTNC 594
Q+ P + GSIV +SSV G+ + Y A+K + +T+ A E AG NIR N
Sbjct: 122 QMVVPYMIKQRNGSIVNVSSVVGIYGNPGQTNYAASKAGVIGMTKTWAKELAGRNIRVNA 181
Query: 595 VAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASYITGQVIS 774
VAP +I+T + + L EK E +SR PLGR G+PEEV+ ++ FL +SY+TGQVI
Sbjct: 182 VAPGFIETPMTEKLPEKA--RETALSRIPLGRFGKPEEVAQVILFLASDESSYVTGQVIG 239
Query: 775 VDGG 786
+DGG
Sbjct: 240 IDGG 243
>sp|Q99LB2|DHRS4_MOUSE Dehydrogenase/reductase SDR family member 4 OS=Mus
musculus GN=Dhrs4 PE=2 SV=1
Length = 260
Score = 154 bits (389), Expect = 8e-037
Identities = 93/249 (37%), Positives = 133/249 (53%), Gaps = 2/249 (0%)
Frame = +1
Query: 43 KRWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTG 222
+R L+ K ALVT T GIG A+ LA GA V SR Q+ + + + GL+VTG
Sbjct: 8 RRNPLSNKVALVTASTDGIGFAIARRLAEDGAHVVVSSRKQQNVDRAVATLQGEGLSVTG 67
Query: 223 SVCDASDRDQREKLIQEVSSAFSGKLNILINNVGTN-IRKPTVEYTSEDYAKIMSINLES 399
VC + REKLI G ++IL++N N ++ T E + K++SIN+ +
Sbjct: 68 IVCHVGKAEDREKLITTALKRHRG-IDILVSNAAVNPFFGNLMDVTEEVWDKVLSINVTA 126
Query: 400 AFHFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDN 579
+ P ++ G GS+V + SVAG S Y +K AL LT+N A E A N
Sbjct: 127 TAMMIKAVVPEMEKRGGGSVVIVGSVAGFTRFPSLGPYNVSKTALLGLTKNFAAELAPKN 186
Query: 580 IRTNCVAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASYIT 759
IR NC+AP IKT L E+K E+ + + R+G+PE+ + +V+FLC ASYI
Sbjct: 187 IRVNCLAPGLIKTRFSSVLWEEKAREDFIKEAMQIRRLGKPEDCAGIVSFLCSEDASYIN 246
Query: 760 GQVISVDGG 786
G+ + V GG
Sbjct: 247 GETVVVGGG 255
>sp|P50199|GNO_GLUOX Gluconate 5-dehydrogenase OS=Gluconobacter oxydans GN=gno
PE=1 SV=1
Length = 256
Score = 154 bits (388), Expect = 1e-036
Identities = 90/250 (36%), Positives = 137/250 (54%), Gaps = 1/250 (0%)
Frame = +1
Query: 49 WSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTGSV 228
+SL+G ALVTG +RGIG + + LAR+GA V RN E L S +++ GL + +V
Sbjct: 7 FSLSGARALVTGASRGIGLTLAKGLARYGAEVVLNGRNAESLDSAQSGFEAEGLKASTAV 66
Query: 229 CDASDRDQREKLIQEVSSAFSGKLNILINNVGTNIRKPTVEYTSEDYAKIMSINLESAFH 408
D +D+D + + G ++ILINN G R P E++ +D+ +MS N+ + F
Sbjct: 67 FDVTDQDAVIDGVAAIERDM-GPIDILINNAGIQRRAPLEEFSRKDWDDLMSTNVNAVFF 125
Query: 409 FSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDNIRT 588
Q + G G IV I SV + + Y ATKGA+ LT+ +A +W ++
Sbjct: 126 VGQAVARHMIPRGRGKIVNICSVQSELARPGIAPYTATKGAVKNLTKGMATDWGRHGLQI 185
Query: 589 NCVAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASYITGQV 768
N +AP Y T + + L+ + F + + RTP GR G+ EE+ FL A+S++ GQV
Sbjct: 186 NGLAPGYFATEMTERLVADEEFTDWLCKRTPAGRWGQVEELVGAAVFLSSRASSFVNGQV 245
Query: 769 ISVDGGFTVN 798
+ VDGG TV+
Sbjct: 246 LMVDGGITVS 255
>sp|Q9BTZ2|DHRS4_HUMAN Dehydrogenase/reductase SDR family member 4 OS=Homo
sapiens GN=DHRS4 PE=1 SV=2
Length = 260
Score = 153 bits (386), Expect = 2e-036
Identities = 93/249 (37%), Positives = 138/249 (55%), Gaps = 2/249 (0%)
Frame = +1
Query: 43 KRWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTG 222
+R LA K ALVT T GIG A+ LA+ GA V SR Q+ + + + GL+VTG
Sbjct: 8 RRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTG 67
Query: 223 SVCDASDRDQREKLIQEVSSAFSGKLNILINNVGTN-IRKPTVEYTSEDYAKIMSINLES 399
+VC + RE+L+ + G ++IL++N N ++ T E + K + IN+++
Sbjct: 68 TVCHVGKAEDRERLV-ATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKA 126
Query: 400 AFHFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDN 579
++ P ++ G GS+V +SS+A S Y +K AL LT+ LA E A N
Sbjct: 127 PALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRN 186
Query: 580 IRTNCVAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASYIT 759
IR NC+AP IKTS + L K EE++ + R+GEPE+ + +V+FLC ASYIT
Sbjct: 187 IRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYIT 246
Query: 760 GQVISVDGG 786
G+ + V GG
Sbjct: 247 GETVVVGGG 255
>sp|Q5RCF8|DHRS4_PONAB Dehydrogenase/reductase SDR family member 4 OS=Pongo
abelii GN=DHRS4 PE=2 SV=2
Length = 260
Score = 153 bits (386), Expect = 2e-036
Identities = 93/249 (37%), Positives = 138/249 (55%), Gaps = 2/249 (0%)
Frame = +1
Query: 43 KRWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTG 222
+R LA K ALVT T GIG A+ LA+ GA V SR Q+ + + + GL+VTG
Sbjct: 8 RRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTG 67
Query: 223 SVCDASDRDQREKLIQEVSSAFSGKLNILINNVGTN-IRKPTVEYTSEDYAKIMSINLES 399
+VC + RE+L+ + G ++IL++N N ++ T E + K + IN+++
Sbjct: 68 TVCHVGKAEDRERLV-ATAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKA 126
Query: 400 AFHFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDN 579
++ P ++ G GS+V +SS+A S Y +K AL LT+ LA E A N
Sbjct: 127 PALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRN 186
Query: 580 IRTNCVAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASYIT 759
IR NC+AP IKTS + L K EE++ + R+GEPE+ + +V+FLC ASYIT
Sbjct: 187 IRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYIT 246
Query: 760 GQVISVDGG 786
G+ + V GG
Sbjct: 247 GETVVVGGG 255
>sp|Q8SPU8|DHRS4_BOVIN Dehydrogenase/reductase SDR family member 4 OS=Bos taurus
GN=DHRS4 PE=2 SV=1
Length = 260
Score = 152 bits (383), Expect = 4e-036
Identities = 91/249 (36%), Positives = 138/249 (55%), Gaps = 2/249 (0%)
Frame = +1
Query: 43 KRWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTG 222
+R L K ALVT T GIG A+ LA+ GA V SR Q+ + + K GL+VTG
Sbjct: 8 RRNPLDNKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDRAVATLKGEGLSVTG 67
Query: 223 SVCDASDRDQREKLIQEVSSAFSGKLNILINNVGTN-IRKPTVEYTSEDYAKIMSINLES 399
+VC + RE+L+ + G ++ILI+N + ++ E + KI+ +N+++
Sbjct: 68 TVCHVGKAEDRERLV-ATAVKLHGGVDILISNAAVSPFFGSLMDVPEEVWDKILDVNVKA 126
Query: 400 AFHFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDN 579
++ P + G GSIV +SS+A S Y +K AL LT+NLA E A N
Sbjct: 127 TALLTKAVVPEMAKRGGGSIVIVSSIAAYSPFPSLGPYNVSKTALLGLTKNLALELAESN 186
Query: 580 IRTNCVAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASYIT 759
+R NC+AP I+TS + L E +E++ + + R+G+PEE + +V+FLC ASYIT
Sbjct: 187 VRVNCLAPGLIRTSFSRVLWEDPARQESIKATFQIKRIGKPEECAGIVSFLCSEDASYIT 246
Query: 760 GQVISVDGG 786
G+ + V GG
Sbjct: 247 GETVVVAGG 255
>sp|Q8WNV7|DHRS4_PIG Dehydrogenase/reductase SDR family member 4 OS=Sus scrofa
GN=DHRS4 PE=1 SV=1
Length = 260
Score = 147 bits (370), Expect = 1e-034
Identities = 89/249 (35%), Positives = 137/249 (55%), Gaps = 2/249 (0%)
Frame = +1
Query: 43 KRWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTG 222
+R L K ALVT T GIG A+ LA+ GA V SR QE + + + GL+VTG
Sbjct: 8 RRKPLENKVALVTASTDGIGLAIARRLAQDGAHVVVSSRKQENVDRTVATLQGEGLSVTG 67
Query: 223 SVCDASDRDQREKLIQEVSSAFSGKLNILINNVGTN-IRKPTVEYTSEDYAKIMSINLES 399
+VC + RE+L+ ++ G ++IL++N N ++ T E + KI+ +N+++
Sbjct: 68 TVCHVGKAEDRERLV-AMAVNLHGGVDILVSNAAVNPFFGNIIDATEEVWDKILHVNVKA 126
Query: 400 AFHFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDN 579
++ P ++ G GS++ +SSV + Y +K AL LT+NLA E A N
Sbjct: 127 TVLMTKAVVPEMEKRGGGSVLIVSSVGAYHPFPNLGPYNVSKTALLGLTKNLAVELAPRN 186
Query: 580 IRTNCVAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASYIT 759
IR NC+AP IKT+ + L K +E + + R+G PE+ + +V+FLC ASYIT
Sbjct: 187 IRVNCLAPGLIKTNFSQVLWMDKARKEYMKESLRIRRLGNPEDCAGIVSFLCSEDASYIT 246
Query: 760 GQVISVDGG 786
G+ + V GG
Sbjct: 247 GETVVVGGG 255
>sp|P0A9Q0|IDNO_ECOL6 Gluconate 5-dehydrogenase OS=Escherichia coli O6 GN=idnO
PE=3 SV=1
Length = 254
Score = 131 bits (328), Expect = 9e-030
Identities = 70/252 (27%), Positives = 127/252 (50%), Gaps = 1/252 (0%)
Frame = +1
Query: 40 NKRWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVT 219
N +SLAGK L+TG +GIG + L ++GA + E + ++ G+
Sbjct: 2 NDLFSLAGKNILITGSAQGIGFLLATGLGKYGAQIIINDITAERAELAVEKLHQEGIQAV 61
Query: 220 GSVCDASDRDQREKLIQEVSSAFSGKLNILINNVGTNIRKPTVEYTSEDYAKIMSINLES 399
+ + + + + + ++ + G +++L+NN G R P E+ +++ ++++N +
Sbjct: 62 AAPFNVTHKHEIDAAVEHIEKDI-GPIDVLVNNAGIQRRHPFTEFPEQEWNDVIAVNQTA 120
Query: 400 AFHFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDN 579
F SQ + G ++ I S+ + + + Y A+KGA+ LTR + E A N
Sbjct: 121 VFLVSQAVTRHMVERKAGKVINICSMQSELGRDTITPYAASKGAVKMLTRGMCVELARHN 180
Query: 580 IRTNCVAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASYIT 759
I+ N +AP Y KT + K L+E + F + RTP R G+P+E+ FL A+ ++
Sbjct: 181 IQVNGIAPGYFKTEMTKALVEDEAFTAWLCKRTPAARWGDPQELIGAAVFLSSKASDFVN 240
Query: 760 GQVISVDGGFTV 795
G ++ VDGG V
Sbjct: 241 GHLLFVDGGMLV 252
>sp|P0A9P9|IDNO_ECOLI Gluconate 5-dehydrogenase OS=Escherichia coli (strain K12)
GN=idnO PE=3 SV=1
Length = 254
Score = 131 bits (328), Expect = 9e-030
Identities = 70/252 (27%), Positives = 127/252 (50%), Gaps = 1/252 (0%)
Frame = +1
Query: 40 NKRWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVT 219
N +SLAGK L+TG +GIG + L ++GA + E + ++ G+
Sbjct: 2 NDLFSLAGKNILITGSAQGIGFLLATGLGKYGAQIIINDITAERAELAVEKLHQEGIQAV 61
Query: 220 GSVCDASDRDQREKLIQEVSSAFSGKLNILINNVGTNIRKPTVEYTSEDYAKIMSINLES 399
+ + + + + + ++ + G +++L+NN G R P E+ +++ ++++N +
Sbjct: 62 AAPFNVTHKHEIDAAVEHIEKDI-GPIDVLVNNAGIQRRHPFTEFPEQEWNDVIAVNQTA 120
Query: 400 AFHFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDN 579
F SQ + G ++ I S+ + + + Y A+KGA+ LTR + E A N
Sbjct: 121 VFLVSQAVTRHMVERKAGKVINICSMQSELGRDTITPYAASKGAVKMLTRGMCVELARHN 180
Query: 580 IRTNCVAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASYIT 759
I+ N +AP Y KT + K L+E + F + RTP R G+P+E+ FL A+ ++
Sbjct: 181 IQVNGIAPGYFKTEMTKALVEDEAFTAWLCKRTPAARWGDPQELIGAAVFLSSKASDFVN 240
Query: 760 GQVISVDGGFTV 795
G ++ VDGG V
Sbjct: 241 GHLLFVDGGMLV 252
>sp|P0CG22|DR4L1_HUMAN Putative dehydrogenase/reductase SDR family member 4-like
2 OS=Homo sapiens GN=DHRS4L1 PE=5 SV=1
Length = 281
Score = 127 bits (319), Expect = 1e-028
Identities = 87/253 (34%), Positives = 132/253 (52%), Gaps = 7/253 (2%)
Frame = +1
Query: 43 KRWSLAGKTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTG 222
+R L K ALVT T IG AV + LA+ GA V R Q+ + + + GL++TG
Sbjct: 26 RRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTG 85
Query: 223 SVCDASDRDQREKLIQEVSSAFSGKLNILINNVGTNIRKPTVEYT-----SEDYAKIMSI 387
+VC E+L+ + G ++IL ++ TN ++ +T E + + + I
Sbjct: 86 TVCHVGKMKDWERLV-ATAMKLHGVIDILSLSI-TNSKRGLFWFTLLQTAEEAWDRNLDI 143
Query: 388 NLESAFHFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEW 567
N ++ + P ++ G GS+ F++SVA L S Y +K AL L + LA E
Sbjct: 144 NGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIEL 203
Query: 568 AGDNIRTNCVAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAA 747
A NIR NC+AP IKTS + L K EE++ + R+GEPE+ +V+FLC A
Sbjct: 204 APRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSEDA 263
Query: 748 SYITGQVISVDGG 786
SY+TG+ + V GG
Sbjct: 264 SYLTGETVMVGGG 276
>sp|Q8KWT4|BACC2_BACSU Bacilysin biosynthesis oxidoreductase BacC OS=Bacillus
subtilis GN=bacC PE=3 SV=1
Length = 253
Score = 127 bits (318), Expect = 1e-028
Identities = 86/249 (34%), Positives = 130/249 (52%), Gaps = 9/249 (3%)
Frame = +1
Query: 64 KTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTGSVCDASD 243
KT L+TGG GIG A V+ A V ++ + ++ + K N + D +D
Sbjct: 6 KTVLITGGASGIGYAAVQAFLNQQANVVVADIDEAQGEAMIR--KENNDRLHFVHTDITD 63
Query: 244 RDQREKLIQEVSSAFSGKLNILINNVGTNIRKPTVEYTSEDYAKIMSINLESAFHFSQIA 423
+ I+ F G L++LINN G I P E ++ K++++NL F S+ A
Sbjct: 64 EPACQNAIRSAVDKFGG-LDVLINNAGIEIVAPIHEMELSNWNKVLNVNLTGMFLMSKHA 122
Query: 424 HPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDNIRTNCVAP 603
+ SG G+I+ SV G+V Y A+KG + QLTR++A ++A NIR NCV P
Sbjct: 123 LKYMLKSGKGNIINTCSVGGVVAWPDIPAYNASKGGVLQLTRSMAVDYAKHNIRVNCVCP 182
Query: 604 WYIKTSL-VKPLLE-KKGFEEAVVSR----TPLGRVGEPEEVSSLVAFLCLPAASYITGQ 765
I T L K LE +G E + PL R+G+PEE+++++ FL +SY+TG
Sbjct: 183 GIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRLGKPEEIANVMLFLASDLSSYMTGS 242
Query: 766 VISVDGGFT 792
I+ DGG+T
Sbjct: 243 AITADGGYT 251
>sp|P50842|KDUD_BACSU 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase OS=Bacillus
subtilis GN=kduD PE=3 SV=1
Length = 254
Score = 127 bits (317), Expect = 2e-028
Identities = 79/252 (31%), Positives = 131/252 (51%), Gaps = 13/252 (5%)
Frame = +1
Query: 49 WSLAGKTALVTGGTRGIGRAVVEELARFGA----TVHTCSRNQEELKSCLDDWKSNGLAV 216
+SL GKTALVTG GIG+ + + LA GA T HT S ++ + + G
Sbjct: 8 FSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSHTSSLSETQQLV-----EQEGRIF 62
Query: 217 TGSVCDASDRDQREKLIQEVSSAFSGK-LNILINNVGTNIRKPTVEYTSEDYAKIMSINL 393
T D S + E + + F + ++IL+NN G R+ ++ E++ ++++NL
Sbjct: 63 TSFTLDMS---KPEAIKDSAAELFENRQIDILVNNAGIIHREKAEDFPEENWQHVLNVNL 119
Query: 394 ESAFHFSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAG 573
S F +Q+A + G G I+ I+S+ Y A+K A+ LT++ A EWA
Sbjct: 120 NSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYTASKHAVAGLTKSFANEWAA 179
Query: 574 DNIRTNCVAPWYIKTSLVKPLLEKKGFEEAVVSRTPLGRVGEPEEVSSLVAFLCLPAASY 753
I+ N +AP YI T+ KP+ + + E ++ R P GR G+ +++ FL A+ Y
Sbjct: 180 SGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGRWGQADDIGGTAVFLASRASDY 239
Query: 754 ITGQVISVDGGF 789
+ G +++VDGG+
Sbjct: 240 VNGHILAVDGGW 251
>sp|P39640|BACC_BACSU Bacilysin biosynthesis oxidoreductase BacC OS=Bacillus
subtilis GN=bacC PE=3 SV=2
Length = 253
Score = 125 bits (312), Expect = 7e-028
Identities = 86/249 (34%), Positives = 128/249 (51%), Gaps = 9/249 (3%)
Frame = +1
Query: 64 KTALVTGGTRGIGRAVVEELARFGATVHTCSRNQEELKSCLDDWKSNGLAVTGSVCDASD 243
KT L+TGG GIG A V+ A G + + +E + K N + D +D
Sbjct: 6 KTVLITGGASGIGYAAVQ--AFLGQQANVVVADIDEAQGEAMVRKENNDRLHFVQTDITD 63
Query: 244 RDQREKLIQEVSSAFSGKLNILINNVGTNIRKPTVEYTSEDYAKIMSINLESAFHFSQIA 423
+ ++ F G L++LINN G I P E D+ K++ +NL F S+ A
Sbjct: 64 EAACQHAVESAVHTFGG-LDVLINNAGIEIVAPIHEMELSDWNKVLQVNLTGMFLMSKHA 122
Query: 424 HPLLKASGVGSIVFISSVAGLVHLSSGSVYGATKGALNQLTRNLACEWAGDNIRTNCVAP 603
+ A+G G+I+ SV GLV Y A+KG + QLT+++A ++A IR NCV P
Sbjct: 123 LKHMLAAGKGNIINTCSVGGLVAWPDIPAYNASKGGVLQLTKSMAVDYAKHQIRVNCVCP 182
Query: 604 WYIKTSL-VKPLLE-KKGFEEAVVSR----TPLGRVGEPEEVSSLVAFLCLPAASYITGQ 765
I T L K LE +G E + PL R+G+PEE+++++ FL +SY+TG
Sbjct: 183 GIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRLGKPEEIANVMLFLASDLSSYMTGS 242
Query: 766 VISVDGGFT 792
I+ DGG+T
Sbjct: 243 AITADGGYT 251
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,851,905,190
Number of Sequences: 518415
Number of Extensions: 48851905190
Number of Successful Extensions: 346316827
Number of sequences better than 0.0: 0
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