BLASTX 7.6.2
Query= UN12306 /QuerySize=738
(737 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54NZ5|CUL3_DICDI Cullin-3 OS=Dictyostelium discoideum GN=cul... 173 2e-042
sp|Q6DE95|CUL3A_XENLA Cullin-3-A OS=Xenopus laevis GN=cul3a PE=1... 166 1e-040
sp|Q6GPF3|CUL3B_XENLA Cullin-3-B OS=Xenopus laevis GN=cul3b PE=1... 166 1e-040
sp|Q13618|CUL3_HUMAN Cullin-3 OS=Homo sapiens GN=CUL3 PE=1 SV=2 166 1e-040
sp|Q9JLV5|CUL3_MOUSE Cullin-3 OS=Mus musculus GN=Cul3 PE=1 SV=1 166 1e-040
sp|A4IHP4|CUL3_XENTR Cullin-3 OS=Xenopus tropicalis GN=cul3 PE=2... 166 1e-040
sp|Q13619|CUL4A_HUMAN Cullin-4A OS=Homo sapiens GN=CUL4A PE=1 SV=3 118 4e-026
sp|Q17391|CUL3_CAEEL Cullin-3 OS=Caenorhabditis elegans GN=cul-3... 104 6e-022
sp|Q09760|CUL3_SCHPO Cullin-3 OS=Schizosaccharomyces pombe GN=cu... 96 2e-019
sp|Q54CS2|CUL4_DICDI Cullin-4 OS=Dictyostelium discoideum GN=cul... 88 5e-017
>sp|Q54NZ5|CUL3_DICDI Cullin-3 OS=Dictyostelium discoideum GN=culC PE=3 SV=1
Length = 769
Score = 173 bits (436), Expect = 2e-042
Identities = 86/183 (46%), Positives = 119/183 (65%), Gaps = 3/183 (1%)
Frame = +3
Query: 9 HLKEKAKLIEAAQGGAFLEELNKKWNEHNKALEMIRDILMYMDRTYIESTKKPHVHPMGL 188
HLK AK + + FL ELN W H ++ MIRDILMYMDR Y++ V +GL
Sbjct: 80 HLKAVAKTVSESIDEKFLLELNSSWINHKTSMLMIRDILMYMDRNYVKQNNLSSVFDLGL 139
Query: 189 SLWRDNVVHSVKIHARLLNTLLDLVHRERTGEVIDRGLVRNVTKMFMDLG---ESVYQDD 359
L+RDNV H I RLLNTLL +V +ER GEVIDR L++N+ +M +DLG ++VY +D
Sbjct: 140 YLFRDNVAHCSTIKDRLLNTLLSMVQKEREGEVIDRILIKNIVQMLIDLGVNSKNVYIED 199
Query: 360 FEKPFLEASSEFYKVESMEFIESCDCGEYLRRAEKRLTEEIDRVGHYLDAKSEDKITSVV 539
FEKP L +S Y+ +S I++C C +Y+++ E L EE++RV HYLD+ SE K+ V
Sbjct: 200 FEKPLLLKTSSHYQAQSQTLIQTCSCPDYMKKVEICLKEELERVSHYLDSSSEPKLKEVC 259
Query: 540 ERE 548
E++
Sbjct: 260 EKQ 262
Score = 81 bits (198), Expect = 7e-015
Identities = 35/65 (53%), Positives = 56/65 (86%)
Frame = +2
Query: 542 EREMIANHMQRLVHMENSGLVNMLLNDKYEDLGRMYNLFRRVTNGLATVRDVMTSHLREM 721
E+++I+NHM+ L+ MENSGL++ML +DK EDL RMYNLF RV++GL ++DV++S+++E+
Sbjct: 260 EKQLISNHMRTLIDMENSGLISMLKDDKIEDLKRMYNLFSRVSDGLNLMKDVISSYVKEI 319
Query: 722 GKQLV 736
G+ +V
Sbjct: 320 GRGIV 324
>sp|Q6DE95|CUL3A_XENLA Cullin-3-A OS=Xenopus laevis GN=cul3a PE=1 SV=1
Length = 768
Score = 166 bits (420), Expect = 1e-040
Identities = 82/167 (49%), Positives = 113/167 (67%), Gaps = 3/167 (1%)
Frame = +3
Query: 57 FLEELNKKWNEHNKALEMIRDILMYMDRTYIESTKKPHVHPMGLSLWRDNVVHSVKIHAR 236
FL+ LN+ WN+H A+ MIRDILMYMDR Y++ +V+ +GL ++RD VV I
Sbjct: 101 FLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDH 160
Query: 237 LLNTLLDLVHRERTGEVIDRGLVRNVTKMFMDL---GESVYQDDFEKPFLEASSEFYKVE 407
L TLLD++ RER GEV+DRG +RN +M M L G SVY++DFE PFLE S+EF+++E
Sbjct: 161 LRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQME 220
Query: 408 SMEFIESCDCGEYLRRAEKRLTEEIDRVGHYLDAKSEDKITSVVERE 548
S +F+ Y+++ E R+ EEI+RV H LD +E+ I VVERE
Sbjct: 221 SQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERE 267
Score = 77 bits (189), Expect = 8e-014
Identities = 39/65 (60%), Positives = 48/65 (73%)
Frame = +2
Query: 542 EREMIANHMQRLVHMENSGLVNMLLNDKYEDLGRMYNLFRRVTNGLATVRDVMTSHLREM 721
ERE+I+ HM+ +V MENSGLV+ML N K EDL MY LF RV NGL T+ + M+ +LRE
Sbjct: 265 ERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQ 324
Query: 722 GKQLV 736
GK LV
Sbjct: 325 GKALV 329
>sp|Q6GPF3|CUL3B_XENLA Cullin-3-B OS=Xenopus laevis GN=cul3b PE=1 SV=1
Length = 768
Score = 166 bits (420), Expect = 1e-040
Identities = 82/167 (49%), Positives = 113/167 (67%), Gaps = 3/167 (1%)
Frame = +3
Query: 57 FLEELNKKWNEHNKALEMIRDILMYMDRTYIESTKKPHVHPMGLSLWRDNVVHSVKIHAR 236
FL+ LN+ WN+H A+ MIRDILMYMDR Y++ +V+ +GL ++RD VV I
Sbjct: 101 FLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDH 160
Query: 237 LLNTLLDLVHRERTGEVIDRGLVRNVTKMFMDL---GESVYQDDFEKPFLEASSEFYKVE 407
L TLLD++ RER GEV+DRG +RN +M M L G SVY++DFE PFLE S+EF+++E
Sbjct: 161 LRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQME 220
Query: 408 SMEFIESCDCGEYLRRAEKRLTEEIDRVGHYLDAKSEDKITSVVERE 548
S +F+ Y+++ E R+ EEI+RV H LD +E+ I VVERE
Sbjct: 221 SQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERE 267
Score = 77 bits (189), Expect = 8e-014
Identities = 39/65 (60%), Positives = 48/65 (73%)
Frame = +2
Query: 542 EREMIANHMQRLVHMENSGLVNMLLNDKYEDLGRMYNLFRRVTNGLATVRDVMTSHLREM 721
ERE+I+ HM+ +V MENSGLV+ML N K EDL MY LF RV NGL T+ + M+ +LRE
Sbjct: 265 ERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQ 324
Query: 722 GKQLV 736
GK LV
Sbjct: 325 GKALV 329
>sp|Q13618|CUL3_HUMAN Cullin-3 OS=Homo sapiens GN=CUL3 PE=1 SV=2
Length = 768
Score = 166 bits (420), Expect = 1e-040
Identities = 82/167 (49%), Positives = 113/167 (67%), Gaps = 3/167 (1%)
Frame = +3
Query: 57 FLEELNKKWNEHNKALEMIRDILMYMDRTYIESTKKPHVHPMGLSLWRDNVVHSVKIHAR 236
FL+ LN+ WN+H A+ MIRDILMYMDR Y++ +V+ +GL ++RD VV I
Sbjct: 101 FLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDH 160
Query: 237 LLNTLLDLVHRERTGEVIDRGLVRNVTKMFMDL---GESVYQDDFEKPFLEASSEFYKVE 407
L TLLD++ RER GEV+DRG +RN +M M L G SVY++DFE PFLE S+EF+++E
Sbjct: 161 LRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQME 220
Query: 408 SMEFIESCDCGEYLRRAEKRLTEEIDRVGHYLDAKSEDKITSVVERE 548
S +F+ Y+++ E R+ EEI+RV H LD +E+ I VVERE
Sbjct: 221 SQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERE 267
Score = 82 bits (201), Expect = 3e-015
Identities = 41/65 (63%), Positives = 50/65 (76%)
Frame = +2
Query: 542 EREMIANHMQRLVHMENSGLVNMLLNDKYEDLGRMYNLFRRVTNGLATVRDVMTSHLREM 721
ERE+I+ HM+ +V MENSGLV+ML N K EDLG MY LF RV NGL T+ + M+S+LRE
Sbjct: 265 ERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQ 324
Query: 722 GKQLV 736
GK LV
Sbjct: 325 GKALV 329
>sp|Q9JLV5|CUL3_MOUSE Cullin-3 OS=Mus musculus GN=Cul3 PE=1 SV=1
Length = 768
Score = 166 bits (420), Expect = 1e-040
Identities = 82/167 (49%), Positives = 113/167 (67%), Gaps = 3/167 (1%)
Frame = +3
Query: 57 FLEELNKKWNEHNKALEMIRDILMYMDRTYIESTKKPHVHPMGLSLWRDNVVHSVKIHAR 236
FL+ LN+ WN+H A+ MIRDILMYMDR Y++ +V+ +GL ++RD VV I
Sbjct: 101 FLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDH 160
Query: 237 LLNTLLDLVHRERTGEVIDRGLVRNVTKMFMDL---GESVYQDDFEKPFLEASSEFYKVE 407
L TLLD++ RER GEV+DRG +RN +M M L G SVY++DFE PFLE S+EF+++E
Sbjct: 161 LRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQME 220
Query: 408 SMEFIESCDCGEYLRRAEKRLTEEIDRVGHYLDAKSEDKITSVVERE 548
S +F+ Y+++ E R+ EEI+RV H LD +E+ I VVERE
Sbjct: 221 SQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERE 267
Score = 78 bits (190), Expect = 6e-014
Identities = 39/65 (60%), Positives = 48/65 (73%)
Frame = +2
Query: 542 EREMIANHMQRLVHMENSGLVNMLLNDKYEDLGRMYNLFRRVTNGLATVRDVMTSHLREM 721
ERE+I+ HM+ +V MENSGLV+ML N K EDL MY LF RV NGL T+ + M+ +LRE
Sbjct: 265 ERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSCYLREQ 324
Query: 722 GKQLV 736
GK LV
Sbjct: 325 GKALV 329
>sp|A4IHP4|CUL3_XENTR Cullin-3 OS=Xenopus tropicalis GN=cul3 PE=2 SV=1
Length = 768
Score = 166 bits (420), Expect = 1e-040
Identities = 82/167 (49%), Positives = 113/167 (67%), Gaps = 3/167 (1%)
Frame = +3
Query: 57 FLEELNKKWNEHNKALEMIRDILMYMDRTYIESTKKPHVHPMGLSLWRDNVVHSVKIHAR 236
FL+ LN+ WN+H A+ MIRDILMYMDR Y++ +V+ +GL ++RD VV I
Sbjct: 101 FLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDH 160
Query: 237 LLNTLLDLVHRERTGEVIDRGLVRNVTKMFMDL---GESVYQDDFEKPFLEASSEFYKVE 407
L TLLD++ RER GEV+DRG +RN +M M L G SVY++DFE PFLE S+EF+++E
Sbjct: 161 LRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQME 220
Query: 408 SMEFIESCDCGEYLRRAEKRLTEEIDRVGHYLDAKSEDKITSVVERE 548
S +F+ Y+++ E R+ EEI+RV H LD +E+ I VVERE
Sbjct: 221 SQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERE 267
Score = 77 bits (189), Expect = 8e-014
Identities = 39/65 (60%), Positives = 48/65 (73%)
Frame = +2
Query: 542 EREMIANHMQRLVHMENSGLVNMLLNDKYEDLGRMYNLFRRVTNGLATVRDVMTSHLREM 721
ERE+I+ HM+ +V MENSGLV+ML N K EDL MY LF RV NGL T+ + M+ +LRE
Sbjct: 265 ERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQ 324
Query: 722 GKQLV 736
GK LV
Sbjct: 325 GKALV 329
>sp|Q13619|CUL4A_HUMAN Cullin-4A OS=Homo sapiens GN=CUL4A PE=1 SV=3
Length = 759
Score = 118 bits (295), Expect = 4e-026
Identities = 59/165 (35%), Positives = 101/165 (61%), Gaps = 3/165 (1%)
Frame = +3
Query: 57 FLEELNKKWNEHNKALEMIRDILMYMDRTYI-ESTKKPHVHPMGLSLWRDNVVHSVKIHA 233
FL+++N W +H + + MIR I +++DRTY+ +++ P + MGL L+R +++ + +
Sbjct: 131 FLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQS 190
Query: 234 RLLNTLLDLVHRERTGEVIDRGLVRNVTKMFMDLGESVYQDDFEKPFLEASSEFYKVESM 413
+ ++ +L L+ RER+GE +DR L+R++ M DL VY+D FE FLE ++ Y E
Sbjct: 191 KTIDGILLLIERERSGEAVDRSLLRSLLGMLSDL--QVYKDSFELKFLEETNCLYAAEGQ 248
Query: 414 EFIESCDCGEYLRRAEKRLTEEIDRVGHYLDAKSEDKITSVVERE 548
++ + EYL KRL EE DRV YLD ++ + + VE++
Sbjct: 249 RLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQ 293
>sp|Q17391|CUL3_CAEEL Cullin-3 OS=Caenorhabditis elegans GN=cul-3 PE=1 SV=2
Length = 777
Score = 104 bits (259), Expect = 6e-022
Identities = 60/181 (33%), Positives = 101/181 (55%), Gaps = 9/181 (4%)
Frame = +3
Query: 21 KAKLIEAAQGGAFLEELNKKWNEHNKALEMIRDILMYMDRTYIESTKKPHVHP---MGLS 191
+ ++IE+ G+FLE + + W +H A+ MIRDILMYMDR Y+ + HV P +GL
Sbjct: 86 RIRIIESMNSGSFLETVAESWADHTVAMVMIRDILMYMDRIYV--AQNNHVLPVYNLGLD 143
Query: 192 LWRDNVVHSVKIHARLLNTLLDLVHRERTGEVIDRGLVRNVTKMFMDLG---ESVYQDDF 362
+R ++ I R+ + LL+L+ +R I+ ++N M + LG +VY+D+F
Sbjct: 144 AYRTEILRQNGIGDRIRDALLELIKLDRKSNQINWHGIKNACDMLISLGIDSRTVYEDEF 203
Query: 363 EKPFLEASSEFYKVESMEFIE-SCDCGEYLRRAEKRLTEEIDRVGHYLDAKSEDKITSVV 539
E+P L+ +S++Y+ ++ D YL + E + +E R YLD +E KI V+
Sbjct: 204 ERPLLKETSDYYRDVCKNWLSGDNDACFYLAQVEIAMHDEASRASRYLDKMTEAKILQVM 263
Query: 540 E 542
+
Sbjct: 264 D 264
>sp|Q09760|CUL3_SCHPO Cullin-3 OS=Schizosaccharomyces pombe GN=cul3 PE=1 SV=2
Length = 785
Score = 96 bits (237), Expect = 2e-019
Identities = 62/181 (34%), Positives = 98/181 (54%), Gaps = 8/181 (4%)
Frame = +3
Query: 24 AKLIEAAQGGAFLEELNKKWNEHNKALEMIRDILMYMDRTYIESTKKPHVHPMGLSLWRD 203
++ +EAA FL L W +H +++MI +L Y+D+ Y +S K V+ G+ ++R+
Sbjct: 112 SRSLEAAH--RFLSSLVNSWKDHIVSMQMISSVLKYLDKVYSKSADKVPVNENGIYIFRE 169
Query: 204 NV-VHSVKIHARLLNTLLDLVHRERTGEVIDRGLVRNVTKMFMDL-----GESVYQDDFE 365
V ++S +I + + T+L LV+ ER G I+R L+ + M L E++Y F
Sbjct: 170 VVLLNSFEIGEKCVETILILVYLERKGNTINRPLINDCLDMLNSLPSENKKETLYDVLFA 229
Query: 366 KPFLEASSEFYKVESMEFIESCDCGEYLRRAEKRLTEEIDRVGHYLDAKSEDKITSVVER 545
FL + FY++ES I EYL++AEKR EE +R +YL K + SVVE
Sbjct: 230 PKFLSYTRNFYEIESSTVIGVFGVVEYLKKAEKRFEEEKERSKNYLFTKIASPLLSVVED 289
Query: 546 E 548
E
Sbjct: 290 E 290
>sp|Q54CS2|CUL4_DICDI Cullin-4 OS=Dictyostelium discoideum GN=culD PE=3 SV=1
Length = 802
Score = 88 bits (217), Expect = 5e-017
Identities = 48/166 (28%), Positives = 92/166 (55%), Gaps = 5/166 (3%)
Frame = +3
Query: 57 FLEELNKKWNEHNKALEMIRDILMYMDRTYI--ESTKKPHVHPMGLSLWRDNVVHSVKIH 230
FL+ +N W +H + MIR I +Y+DRTY+ S + +GL + +N+ +
Sbjct: 141 FLKSINSIWKDHTNQMIMIRSIFLYLDRTYVIQNSNTVKSIWDLGLFYFGNNLSQQSNLE 200
Query: 231 ARLLNTLLDLVHRERTGEVIDRGLVRNVTKMFMDLGESVYQDDFEKPFLEASSEFYKVES 410
+ +++LL + ER G+ IDR L+ ++ KM L ++Y FE F++ ++ FY +E
Sbjct: 201 RKTIDSLLYSIRCEREGDEIDRDLIHSLVKMLSSL--NIY-TKFEIEFIKETNRFYDMEG 257
Query: 411 MEFIESCDCGEYLRRAEKRLTEEIDRVGHYLDAKSEDKITSVVERE 548
I + YL+ +RL +E +R+ YL+ ++ ++ +V++R+
Sbjct: 258 NSKINEIETPMYLKYVCERLNQEGERLMRYLEQSTKKQLMAVLDRQ 303
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,796,540,212
Number of Sequences: 518415
Number of Extensions: 51796540212
Number of Successful Extensions: 358348623
Number of sequences better than 0.0: 0
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