BLASTX 7.6.2
Query= UN12435 /QuerySize=933
(932 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54QP6|OSB8_DICDI Oxysterol-binding protein 8 OS=Dictyosteliu... 166 2e-040
sp|Q54ID7|OSB11_DICDI Oxysterol-binding protein 11 OS=Dictyostel... 157 2e-037
sp|Q9BXW6|OSBL1_HUMAN Oxysterol-binding protein-related protein ... 157 2e-037
sp|Q8K4M9|OSBL1_RAT Oxysterol-binding protein-related protein 1 ... 156 2e-037
sp|Q91XL9|OSBL1_MOUSE Oxysterol-binding protein-related protein ... 156 3e-037
sp|Q8BXR9|OSBL6_MOUSE Oxysterol-binding protein-related protein ... 153 2e-036
sp|Q8BX94|OSBL2_MOUSE Oxysterol-binding protein-related protein ... 150 1e-035
sp|Q9BZF3|OSBL6_HUMAN Oxysterol-binding protein-related protein ... 150 1e-035
sp|Q9BZF2|OSBL7_HUMAN Oxysterol-binding protein-related protein ... 150 1e-035
sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c... 150 2e-035
sp|Q9H4L5|OSBL3_HUMAN Oxysterol-binding protein-related protein ... 148 9e-035
sp|Q9DBS9|OSBL3_MOUSE Oxysterol-binding protein-related protein ... 146 4e-034
sp|Q3B7Z2|OSBP1_MOUSE Oxysterol-binding protein 1 OS=Mus musculu... 141 9e-033
sp|P22059|OSBP1_HUMAN Oxysterol-binding protein 1 OS=Homo sapien... 140 2e-032
sp|P16258|OSBP1_RABIT Oxysterol-binding protein 1 OS=Oryctolagus... 140 2e-032
sp|P35845|OSH1_YEAST Oxysterol-binding protein homolog 1 OS=Sacc... 129 3e-029
sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2 OS=Sacc... 124 1e-027
sp|Q54PS9|OSB9_DICDI Oxysterol-binding protein 9 OS=Dictyosteliu... 75 6e-013
>sp|Q54QP6|OSB8_DICDI Oxysterol-binding protein 8 OS=Dictyostelium discoideum
GN=osbH PE=1 SV=1
Length = 402
Score = 166 bits (420), Expect = 2e-040
Identities = 89/240 (37%), Positives = 139/240 (57%), Gaps = 4/240 (1%)
Frame = +2
Query: 218 NGLVGY-EGLEVINPEGSTEDAAEEANRGRWKQEDRDGYWKMMQKYIGSDVTSMVTLPVI 394
+G + Y +GL N E++ + N+G + E R G K + Y+G D+TS+++LPV
Sbjct: 3 SGALNYMKGLVGTNENLQVEESGD--NKGDIEPEQRKGLLKQLSSYVGKDITSLISLPVW 60
Query: 395 IFEPMTMLQKMAELMEYSHLLDLADETEDPYMRMVYASSWAISVYYAFQRTWKPFNPILG 574
IFEP++ LQ M+E ++Y+ LL A + + ++ + Y +++ ++Y RT KPFNPILG
Sbjct: 61 IFEPVSFLQVMSEPLQYNALLSKASKQDSEFLCLAYLAAFNCALYSTAVRTRKPFNPILG 120
Query: 575 ETYEMANYNG-VNFISEQVSHHPPMSAGHAENEHFTYDCTSKLKTKFLGNSIDVYPVGRT 751
ET+E+ + G F++EQVSHHPP+ +E +T + LK+KF GNS +V G
Sbjct: 121 ETFEIVDKKGEFRFLAEQVSHHPPIGVSETISEDYTLQLETLLKSKFYGNSSEVEIDGTN 180
Query: 752 RVTLKRDGVVLDLVPPLTKVHNLIFGRTWVDSPGEMIMTNLTTGDKVVLYFQPCGWFGSG 931
K+ +T HN+I G W+D G++++ N TTG K VL F GW G+G
Sbjct: 181 HFFNKKTNHHYTWNHLVTCCHNIIIGSLWLDHYGDLVIENHTTGSKAVLKFAKSGWLGAG 240
>sp|Q54ID7|OSB11_DICDI Oxysterol-binding protein 11 OS=Dictyostelium discoideum
GN=osbK PE=3 SV=1
Length = 571
Score = 157 bits (395), Expect = 2e-037
Identities = 77/204 (37%), Positives = 118/204 (57%), Gaps = 1/204 (0%)
Frame = +2
Query: 314 EDRDGYWKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADETEDPYMR 493
ED+ WK + +G D S+V+LPV FEP+T+L+ E + + L++ A D R
Sbjct: 88 EDKKSLWKKVGGLVGKDPMSLVSLPVYFFEPLTVLECQLEPLRFVELIEKASTCSDSIDR 147
Query: 494 MVYASSWAISVYYAFQRTWKPFNPILGETYEMANYNG-VNFISEQVSHHPPMSAGHAENE 670
++Y +++ I+V+ ++ RT KPFNP+LGET+E + G EQVSHHPP+ +E
Sbjct: 148 LMYLTAFNIAVFSSYTRTAKPFNPLLGETFEYIDKQGRYKSFCEQVSHHPPIGIAQTTSE 207
Query: 671 HFTYDCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNLIFGRTWVDSP 850
F S + TKF GNS+DV+ G+ + L G P HN+IFG+ W++
Sbjct: 208 IFDLQQESWITTKFWGNSLDVFSHGQNHLYLNSTGEHFTWKVPSAICHNIIFGKMWIEHY 267
Query: 851 GEMIMTNLTTGDKVVLYFQPCGWF 922
G++I+ N TG+K ++ FQ GWF
Sbjct: 268 GDLIVENHNTGEKAIINFQKSGWF 291
>sp|Q9BXW6|OSBL1_HUMAN Oxysterol-binding protein-related protein 1 OS=Homo
sapiens GN=OSBPL1A PE=1 SV=2
Length = 950
Score = 157 bits (395), Expect = 2e-037
Identities = 85/202 (42%), Positives = 122/202 (60%), Gaps = 5/202 (2%)
Frame = +2
Query: 332 WKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADETEDPYMRMVYASS 511
W +++K IG ++ S +T+PVI EP++ LQ++ E ME+++L+ A DP RM ++
Sbjct: 550 WSILRKCIGMEL-SKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAA 608
Query: 512 WAIS-VYYAFQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAE--NEHFT 679
+A+S V ++RT KPFNP+LGETYE+ + G ISEQVSHHPP+SA HAE N F
Sbjct: 609 FAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFI 668
Query: 680 YDCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNLIFGRTWVDSPGEM 859
+ + K KF G S++ P G + L P VHN+I G+ W++ G +
Sbjct: 669 FHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNV 728
Query: 860 IMTNLTTGDKVVLYFQPCGWFG 925
+ N TGDK VL F+PCG FG
Sbjct: 729 EIINHKTGDKCVLNFKPCGLFG 750
>sp|Q8K4M9|OSBL1_RAT Oxysterol-binding protein-related protein 1 OS=Rattus
norvegicus GN=Osbpl1a PE=1 SV=1
Length = 950
Score = 156 bits (394), Expect = 2e-037
Identities = 85/202 (42%), Positives = 122/202 (60%), Gaps = 5/202 (2%)
Frame = +2
Query: 332 WKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADETEDPYMRMVYASS 511
W +++K IG ++ S +T+PVI EP++ LQ++ E ME+++L+ A DP RM ++
Sbjct: 550 WSILRKCIGMEL-SKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSFSDPVERMQCVAA 608
Query: 512 WAIS-VYYAFQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAE--NEHFT 679
+A+S V ++RT KPFNP+LGETYE+ + G ISEQVSHHPP+SA HAE N F
Sbjct: 609 FAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFI 668
Query: 680 YDCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNLIFGRTWVDSPGEM 859
+ + K KF G S++ P G + L P VHN+I G+ W++ G +
Sbjct: 669 FHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNV 728
Query: 860 IMTNLTTGDKVVLYFQPCGWFG 925
+ N TGDK VL F+PCG FG
Sbjct: 729 EIINHKTGDKCVLNFKPCGLFG 750
>sp|Q91XL9|OSBL1_MOUSE Oxysterol-binding protein-related protein 1 OS=Mus
musculus GN=Osbpl1a PE=1 SV=2
Length = 950
Score = 156 bits (393), Expect = 3e-037
Identities = 85/202 (42%), Positives = 122/202 (60%), Gaps = 5/202 (2%)
Frame = +2
Query: 332 WKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADETEDPYMRMVYASS 511
W +++K IG ++ S +T+PVI EP++ LQ++ E ME+++L+ A DP RM ++
Sbjct: 550 WSILRKCIGMEL-SKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAA 608
Query: 512 WAIS-VYYAFQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAE--NEHFT 679
+A+S V ++RT KPFNP+LGETYE+ + G ISEQVSHHPP+SA HAE N F
Sbjct: 609 FAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFI 668
Query: 680 YDCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNLIFGRTWVDSPGEM 859
+ + K KF G S++ P G + L P VHN+I G+ W++ G +
Sbjct: 669 FHGSIYPKLKFWGKSVEAEPKGTITLELLDHNEAYTWTNPTCCVHNIIVGKLWIEQYGNV 728
Query: 860 IMTNLTTGDKVVLYFQPCGWFG 925
+ N TGDK VL F+PCG FG
Sbjct: 729 EIINHKTGDKCVLNFKPCGLFG 750
>sp|Q8BXR9|OSBL6_MOUSE Oxysterol-binding protein-related protein 6 OS=Mus
musculus GN=Osbpl6 PE=2 SV=1
Length = 959
Score = 153 bits (385), Expect = 2e-036
Identities = 81/183 (44%), Positives = 116/183 (63%), Gaps = 4/183 (2%)
Frame = +2
Query: 332 WKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADETEDPYMRMVYASS 511
W +++ IG D+ S V++PV + EP+ LQ + E MEYS LLD A ET+DPY RMV ++
Sbjct: 597 WNILRNNIGKDL-SKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAA 655
Query: 512 WAISVYYA--FQRTWKPFNPILGETYE-MANYNGVNFISEQVSHHPPMSAGHAENEHFTY 682
+A+S Y + F+ KPFNP+LGETYE + G F SEQVSHHPP+SA H E+++F +
Sbjct: 656 FAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVF 715
Query: 683 DCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNLIFGRTWVDSPGEMI 862
+ K KF G S+++ PVG VTL + G T +HN++ GR W++ GE+
Sbjct: 716 WQDIRWKNKFWGKSMEILPVGTLNVTLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVT 775
Query: 863 MTN 871
+ N
Sbjct: 776 LRN 778
>sp|Q8BX94|OSBL2_MOUSE Oxysterol-binding protein-related protein 2 OS=Mus
musculus GN=Osbpl2 PE=2 SV=1
Length = 484
Score = 150 bits (378), Expect = 1e-035
Identities = 80/202 (39%), Positives = 123/202 (60%), Gaps = 5/202 (2%)
Frame = +2
Query: 332 WKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADETEDPYMRMVYASS 511
W +++K IG ++ S +T+P+ EP++ LQ++ E ME+ +L+ A P RM ++
Sbjct: 77 WSILKKCIGLEL-SKITMPIAFNEPLSFLQRITEYMEHVYLIHKASSQSQPLERMQSVAA 135
Query: 512 WAIS-VYYAFQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAE--NEHFT 679
+A+S V ++RT KPFNP+LGETYE+ + G FISEQVSHHPP+SA ++E N+ F
Sbjct: 136 FAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFYSEGLNQDFR 195
Query: 680 YDCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNLIFGRTWVDSPGEM 859
+ + K KF G S++ P G + L + P VHN+I G+ W++ G +
Sbjct: 196 FHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVILGQLWIEQYGIV 255
Query: 860 IMTNLTTGDKVVLYFQPCGWFG 925
+ N TGDK +L+F+PCG FG
Sbjct: 256 EIVNHRTGDKCILHFKPCGLFG 277
>sp|Q9BZF3|OSBL6_HUMAN Oxysterol-binding protein-related protein 6 OS=Homo
sapiens GN=OSBPL6 PE=1 SV=1
Length = 934
Score = 150 bits (378), Expect = 1e-035
Identities = 80/183 (43%), Positives = 115/183 (62%), Gaps = 4/183 (2%)
Frame = +2
Query: 332 WKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADETEDPYMRMVYASS 511
W +++ IG D+ S V++PV + EP+ LQ + E MEYS LLD A ET+DPY RMV ++
Sbjct: 572 WNILRNNIGKDL-SKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAA 630
Query: 512 WAISVYYA--FQRTWKPFNPILGETYE-MANYNGVNFISEQVSHHPPMSAGHAENEHFTY 682
+A+S Y + F+ KPFNP+LGETYE + G F SEQVSHHPP+SA H E+++F +
Sbjct: 631 FAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVF 690
Query: 683 DCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNLIFGRTWVDSPGEMI 862
+ K KF G S+++ PVG V L + G T +HN++ GR W++ GE+
Sbjct: 691 WQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVT 750
Query: 863 MTN 871
+ N
Sbjct: 751 IRN 753
>sp|Q9BZF2|OSBL7_HUMAN Oxysterol-binding protein-related protein 7 OS=Homo
sapiens GN=OSBPL7 PE=2 SV=1
Length = 842
Score = 150 bits (378), Expect = 1e-035
Identities = 79/183 (43%), Positives = 117/183 (63%), Gaps = 4/183 (2%)
Frame = +2
Query: 332 WKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADETEDPYMRMVYASS 511
W +++ IG D+ S V++PV + EP+ LQ++ E +EYS LLD A DP RMVY ++
Sbjct: 480 WNILRNNIGKDL-SKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAA 538
Query: 512 WAISVYYA--FQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAENEHFTY 682
+A+S Y + + KPFNP+LGETYE + G FISEQVSHHPP+SA HAE+E+F +
Sbjct: 539 FAVSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFAF 598
Query: 683 DCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNLIFGRTWVDSPGEMI 862
K K KF G S+++ PVG V+L R G + + +HN++ G+ W++ GE++
Sbjct: 599 WQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVL 658
Query: 863 MTN 871
+ N
Sbjct: 659 IRN 661
>sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c
OS=Schizosaccharomyces pombe GN=SPBC2F12.05c PE=1 SV=2
Length = 1310
Score = 150 bits (377), Expect = 2e-035
Identities = 84/203 (41%), Positives = 124/203 (61%), Gaps = 6/203 (2%)
Frame = +2
Query: 332 WKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADETEDPYMRMVYASS 511
W +++ IG D+T M TLPV EP ++LQ++AE MEY+ LLD A +DPY R++Y ++
Sbjct: 939 WGILKGMIGKDMTKM-TLPVSFNEPTSLLQRVAEDMEYTELLDQASHNKDPYQRILYVAA 997
Query: 512 WAISVYYA-FQRTWKPFNPILGETYEMAN-YNGVNFISEQVSHHPPMSAGHAENEHFTYD 685
+A S Y + R KPFNP+LGETYE + G FI EQVSHHPP+ A ++E+ ++ Y
Sbjct: 998 FAASEYASTLNRVAKPFNPLLGETYEFCHPQRGFRFIVEQVSHHPPVGAAYSESANWKYY 1057
Query: 686 CTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLV---PPLTKVHNLIFGRTWVDSPGE 856
S +K+KF G S D+ P+G + L+ ++L + V +I G VD+ G+
Sbjct: 1058 GESSVKSKFYGKSFDISPLGTWFLELRHPSGEVELYTWKKVTSSVVGIILGSPSVDNYGQ 1117
Query: 857 MIMTNLTTGDKVVLYFQPCGWFG 925
M + N ++G VL F+P GW G
Sbjct: 1118 MHIVNHSSGINCVLDFKPRGWRG 1140
>sp|Q9H4L5|OSBL3_HUMAN Oxysterol-binding protein-related protein 3 OS=Homo
sapiens GN=OSBPL3 PE=1 SV=1
Length = 887
Score = 148 bits (371), Expect = 9e-035
Identities = 77/184 (41%), Positives = 116/184 (63%), Gaps = 4/184 (2%)
Frame = +2
Query: 332 WKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADETEDPYMRMVYASS 511
W +++ IG D+ S V +PV + EP+ LQ++ E +EYS LLD A + P RMVY ++
Sbjct: 529 WNILRNNIGKDL-SKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAA 587
Query: 512 WAISVYYA--FQRTWKPFNPILGETYE-MANYNGVNFISEQVSHHPPMSAGHAENEHFTY 682
+AIS Y + ++ KPFNP+LGETYE + G F SEQVSHHPP+SA HAE+ +F +
Sbjct: 588 FAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHAESRNFVF 647
Query: 683 DCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNLIFGRTWVDSPGEMI 862
+ K KF G S+++ P+G T VTL G + + +HN++ G+ W++ GE++
Sbjct: 648 WQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIV 707
Query: 863 MTNL 874
+ NL
Sbjct: 708 IKNL 711
>sp|Q9DBS9|OSBL3_MOUSE Oxysterol-binding protein-related protein 3 OS=Mus
musculus GN=Osbpl3 PE=1 SV=1
Length = 855
Score = 146 bits (366), Expect = 4e-034
Identities = 77/184 (41%), Positives = 114/184 (61%), Gaps = 4/184 (2%)
Frame = +2
Query: 332 WKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADETEDPYMRMVYASS 511
W +++ IG D+ S V +PV + EP+ LQ++ E +EYS LLD A P RMVY ++
Sbjct: 497 WSILRNNIGKDL-SKVAMPVELNEPLNTLQRLCEELEYSELLDKASRIPSPLERMVYVAA 555
Query: 512 WAISVYYA--FQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAENEHFTY 682
+AIS Y + F+ KPFNP+LGETYE + G F +EQVSHHPP+SA HAE+ +F +
Sbjct: 556 FAISAYASSYFRAGSKPFNPVLGETYECIRQDKGFQFFAEQVSHHPPISACHAESGNFVF 615
Query: 683 DCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNLIFGRTWVDSPGEMI 862
+ K KF G S+++ P+G T VTL G + + +HN++ G+ W++ GE+
Sbjct: 616 WQDVRWKNKFWGKSMEIVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYGEID 675
Query: 863 MTNL 874
+ NL
Sbjct: 676 IKNL 679
>sp|Q3B7Z2|OSBP1_MOUSE Oxysterol-binding protein 1 OS=Mus musculus GN=Osbp PE=1
SV=2
Length = 751
Score = 141 bits (354), Expect = 9e-033
Identities = 91/274 (33%), Positives = 141/274 (51%), Gaps = 6/274 (2%)
Frame = +2
Query: 116 RGEMAPNDPKNGGGFFASLASSISSLGSAMTKS-VNGLVGYEGLEVINPEGSTEDAAEEA 292
+G+M+ D +N + + +LG T S ++G L+ E E+
Sbjct: 291 KGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDVSLDEQYKHQLEETKKEKR 350
Query: 293 NRGRWKQEDRDGYWKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADE 472
R +K W +M+ IG ++ S + +PV EP++MLQ++ E +EY LLD A +
Sbjct: 351 TRIPYKPNYSLNLWSIMKNCIGKEL-SKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAK 409
Query: 473 TEDPYMRMVYASSWAISVY-YAFQRTWKPFNPILGETYEM--ANYNGVNFISEQVSHHPP 643
E+ ++ Y +++ +S Y RT KPFNP+LGET+E+ NG I EQVSHHPP
Sbjct: 410 CENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSICEQVSHHPP 469
Query: 644 MSAGHAENEH-FTYDCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNL 820
+A HAE+++ +T K+ +KF G + + P+G G T VHN+
Sbjct: 470 AAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHSTGHHYTWKKVTTTVHNI 529
Query: 821 IFGRTWVDSPGEMIMTNLTTGDKVVLYFQPCGWF 922
I G+ W+D GE+ + N TGDK L F P +F
Sbjct: 530 IVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYF 563
>sp|P22059|OSBP1_HUMAN Oxysterol-binding protein 1 OS=Homo sapiens GN=OSBP PE=1
SV=1
Length = 807
Score = 140 bits (351), Expect = 2e-032
Identities = 90/274 (32%), Positives = 141/274 (51%), Gaps = 6/274 (2%)
Frame = +2
Query: 116 RGEMAPNDPKNGGGFFASLASSISSLGSAMTKS-VNGLVGYEGLEVINPEGSTEDAAEEA 292
+G+M+ D +N + + +LG T S ++G L+ E E+
Sbjct: 347 KGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKR 406
Query: 293 NRGRWKQEDRDGYWKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADE 472
R +K W +M+ IG ++ S + +PV EP++MLQ++ E +EY LLD A +
Sbjct: 407 TRIPYKPNYSLNLWSIMKNCIGKEL-SKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAK 465
Query: 473 TEDPYMRMVYASSWAISVY-YAFQRTWKPFNPILGETYEM--ANYNGVNFISEQVSHHPP 643
E+ ++ Y +++ +S Y RT KPFNP+LGET+E+ NG + EQVSHHPP
Sbjct: 466 CENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPP 525
Query: 644 MSAGHAENEH-FTYDCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNL 820
+A HAE+++ +T K+ +KF G + + P+G G T VHN+
Sbjct: 526 AAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNI 585
Query: 821 IFGRTWVDSPGEMIMTNLTTGDKVVLYFQPCGWF 922
I G+ W+D GE+ + N TGDK L F P +F
Sbjct: 586 IVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYF 619
>sp|P16258|OSBP1_RABIT Oxysterol-binding protein 1 OS=Oryctolagus cuniculus
GN=OSBP PE=1 SV=1
Length = 809
Score = 140 bits (351), Expect = 2e-032
Identities = 90/274 (32%), Positives = 141/274 (51%), Gaps = 6/274 (2%)
Frame = +2
Query: 116 RGEMAPNDPKNGGGFFASLASSISSLGSAMTKS-VNGLVGYEGLEVINPEGSTEDAAEEA 292
+G+M+ D +N + + +LG T S ++G L+ E E+
Sbjct: 349 KGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKR 408
Query: 293 NRGRWKQEDRDGYWKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADE 472
R +K W +M+ IG ++ S + +PV EP++MLQ++ E +EY LLD A +
Sbjct: 409 TRIPYKPNYSLNLWSIMKNCIGKEL-SKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAK 467
Query: 473 TEDPYMRMVYASSWAISVY-YAFQRTWKPFNPILGETYEM--ANYNGVNFISEQVSHHPP 643
E+ ++ Y +++ +S Y RT KPFNP+LGET+E+ NG + EQVSHHPP
Sbjct: 468 CENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPP 527
Query: 644 MSAGHAENEH-FTYDCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNL 820
+A HAE+++ +T K+ +KF G + + P+G G T VHN+
Sbjct: 528 AAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNI 587
Query: 821 IFGRTWVDSPGEMIMTNLTTGDKVVLYFQPCGWF 922
I G+ W+D GE+ + N TGDK L F P +F
Sbjct: 588 IVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYF 621
>sp|P35845|OSH1_YEAST Oxysterol-binding protein homolog 1 OS=Saccharomyces
cerevisiae GN=OSH1 PE=1 SV=4
Length = 1188
Score = 129 bits (323), Expect = 3e-029
Identities = 77/221 (34%), Positives = 127/221 (57%), Gaps = 15/221 (6%)
Frame = +2
Query: 269 TEDAAEEANRGRWKQEDRDGYWKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYS 448
T+ A +E NR + G W +++ +G D+T + TLPV EP ++LQ+++E +EYS
Sbjct: 786 TKLALDEDNR------PKIGLWSVLKSMVGQDLTKL-TLPVSFNEPTSLLQRVSEDIEYS 838
Query: 449 HLLDLADETEDPYMRMVYASSWAISVYYA-FQRTWKPFNPILGETYEMANYNG-VNFISE 622
H+LD A ED +RM+Y +++ S+Y + R KPFNP+LGET+E A +G F +E
Sbjct: 839 HILDQAATFEDSSLRMLYVAAFTASMYASTTNRVSKPFNPLLGETFEYARTDGQYRFFTE 898
Query: 623 QVSHHPPMSAGHAENEHFTYDCTSKLKTKFLGNSIDVYPVGRTRVTLKRDGVV------L 784
QVSHHPP+SA E+ + + + + F G + V +G +T++ D +
Sbjct: 899 QVSHHPPISATWTESPKWDFYGECNVDSSFNGRTFAVQHLGLWYITIRPDHNISVPEETY 958
Query: 785 DLVPPLTKVHNLIFGRTWVDSPGEMIMTNLTTGDKVVLYFQ 907
P V ++ G+ VD+ G++ +TN TTGD +L+++
Sbjct: 959 SWKKPNNTVIGILMGKPQVDNSGDVKVTNHTTGDYCMLHYK 999
>sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2 OS=Saccharomyces
cerevisiae GN=OSH2 PE=1 SV=1
Length = 1283
Score = 124 bits (309), Expect = 1e-027
Identities = 77/198 (38%), Positives = 115/198 (58%), Gaps = 7/198 (3%)
Frame = +2
Query: 332 WKMMQKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDLADETEDPYMRMVYASS 511
W +++ +G D+T M TLPV EP ++LQ++AE +EYS LLD A ED +R +Y ++
Sbjct: 899 WAVLKSMVGKDMTRM-TLPVTFNEPTSLLQRVAEDLEYSELLDQAATFEDSTLRTLYVAA 957
Query: 512 WAISVYYA-FQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAENEHFTYD 685
+ S Y + +R KPFNP+LGET+E + + F +EQVSHHPP+SA E+ + +
Sbjct: 958 FTASSYASTTKRVAKPFNPLLGETFEYSRPDKQYRFFTEQVSHHPPISATWTESPRWDFW 1017
Query: 686 CTSKLKTKFLGNSIDVYPVGRTRVTLK-RDGVVLDLV---PPLTKVHNLIFGRTWVDSPG 853
S + TKF G S +V +G + L+ D +L P V ++ G VD+ G
Sbjct: 1018 GESFVDTKFNGRSFNVKHLGLWHIKLRPNDNEKEELYTWKKPNNTVIGILIGNPQVDNHG 1077
Query: 854 EMIMTNLTTGDKVVLYFQ 907
E+ + N TTGD LYF+
Sbjct: 1078 EVNVVNHTTGDHCKLYFK 1095
>sp|Q54PS9|OSB9_DICDI Oxysterol-binding protein 9 OS=Dictyostelium discoideum
GN=osbI PE=3 SV=1
Length = 428
Score = 75 bits (183), Expect = 6e-013
Identities = 55/188 (29%), Positives = 86/188 (45%), Gaps = 5/188 (2%)
Frame = +2
Query: 356 GSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHL-LDLADETEDPYMRMVYASSWAISVYY 532
G ++TS LP+ +FE + L+K+ + M + L L A ET DP RM +S+ +S +
Sbjct: 102 GKELTS-TCLPIELFEARSFLEKVTDTMAFGPLYLKAAAETNDPIERMKMVASFVVSGLH 160
Query: 533 AFQRTWKPFNPILGETYEMANYNGVNFISEQVSHHPPMSAGHAENEHFTYDCTSKL--KT 706
KPFNP+LGET+E +G + EQ+SHHPP+S+ + Y T
Sbjct: 161 LTTTIAKPFNPLLGETFECDLADGSSAFCEQISHHPPISSWKLLEKDGKYKYTGHFIWSA 220
Query: 707 KFLGNSIDVYPVGRTRVTLKRDGVVLDLVPPLTKVHNLIFGRTWVDSPGEMIMTNLTTGD 886
GN + G + DG + P + + +G + G+M+ T+
Sbjct: 221 GCRGNVVKGCLKGPHNIEF-ADGTNIAFTYPDVLIKGIFWGDRVTEFCGKMLFTDEKNDL 279
Query: 887 KVVLYFQP 910
L F P
Sbjct: 280 ACELIFNP 287
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,796,540,212
Number of Sequences: 518415
Number of Extensions: 51796540212
Number of Successful Extensions: 358348623
Number of sequences better than 0.0: 0
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