BLASTX 7.6.2
Query= UN12455 /QuerySize=788
(787 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54QP6|OSB8_DICDI Oxysterol-binding protein 8 OS=Dictyosteliu... 127 1e-028
sp|Q9BZF3|OSBL6_HUMAN Oxysterol-binding protein-related protein ... 124 6e-028
sp|Q8BXR9|OSBL6_MOUSE Oxysterol-binding protein-related protein ... 124 6e-028
sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c... 124 8e-028
sp|Q9BZF2|OSBL7_HUMAN Oxysterol-binding protein-related protein ... 123 1e-027
sp|Q9H4L5|OSBL3_HUMAN Oxysterol-binding protein-related protein ... 117 1e-025
sp|Q9DBS9|OSBL3_MOUSE Oxysterol-binding protein-related protein ... 117 1e-025
sp|Q9BXW6|OSBL1_HUMAN Oxysterol-binding protein-related protein ... 112 3e-024
sp|Q54ID7|OSB11_DICDI Oxysterol-binding protein 11 OS=Dictyostel... 109 4e-023
sp|Q9H1P3|OSBL2_HUMAN Oxysterol-binding protein-related protein ... 105 4e-022
sp|P35845|OSH1_YEAST Oxysterol-binding protein homolog 1 OS=Sacc... 103 2e-021
sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2 OS=Sacc... 100 2e-020
sp|Q54PS9|OSB9_DICDI Oxysterol-binding protein 9 OS=Dictyosteliu... 72 4e-012
>sp|Q54QP6|OSB8_DICDI Oxysterol-binding protein 8 OS=Dictyostelium discoideum
GN=osbH PE=1 SV=1
Length = 402
Score = 127 bits (317), Expect = 1e-028
Identities = 65/174 (37%), Positives = 109/174 (62%), Gaps = 4/174 (2%)
Frame = +2
Query: 182 NGLVGY-EGLEVINPEGSTEDAAEEANRGRWKQEERDGYWKMMQKYIGSDVTSMVTLPVI 358
+G + Y +GL N E++ + N+G + E+R G K + Y+G D+TS+++LPV
Sbjct: 3 SGALNYMKGLVGTNENLQVEESGD--NKGDIEPEQRKGLLKQLSSYVGKDITSLISLPVW 60
Query: 359 IFGPMTMLQKMAELMEYSHLLEMANETEDPYMRMVYASSWAISVYYAFQRTWKPFNPILG 538
IF P++ LQ M+E ++Y+ LL A++ + ++ + Y +++ ++Y RT KPFNPILG
Sbjct: 61 IFEPVSFLQVMSEPLQYNALLSKASKQDSEFLCLAYLAAFNCALYSTAVRTRKPFNPILG 120
Query: 539 ETYEMANYNG-VNFISEQVSHHPPMSAGHAENEHFTYDCTSKLKTKFLGSSIDV 697
ET+E+ + G F++EQVSHHPP+ +E +T + LK+KF G+S +V
Sbjct: 121 ETFEIVDKKGEFRFLAEQVSHHPPIGVSETISEDYTLQLETLLKSKFYGNSSEV 174
>sp|Q9BZF3|OSBL6_HUMAN Oxysterol-binding protein-related protein 6 OS=Homo
sapiens GN=OSBPL6 PE=1 SV=1
Length = 934
Score = 124 bits (311), Expect = 6e-028
Identities = 65/140 (46%), Positives = 94/140 (67%), Gaps = 4/140 (2%)
Frame = +2
Query: 296 WKMMQKYIGSDVTSMVTLPVIIFGPMTMLQKMAELMEYSHLLEMANETEDPYMRMVYASS 475
W +++ IG D+ S V++PV + P+ LQ + E MEYS LL+ A+ET+DPY RMV ++
Sbjct: 572 WNILRNNIGKDL-SKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAA 630
Query: 476 WAISVYYA--FQRTWKPFNPILGETYE-MANYNGVNFISEQVSHHPPMSAGHAENEHFTY 646
+A+S Y + F+ KPFNP+LGETYE + G F SEQVSHHPP+SA H E+++F +
Sbjct: 631 FAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVF 690
Query: 647 DCTSKLKTKFLGSSIDVYPV 706
+ K KF G S+++ PV
Sbjct: 691 WQDIRWKNKFWGKSMEILPV 710
>sp|Q8BXR9|OSBL6_MOUSE Oxysterol-binding protein-related protein 6 OS=Mus
musculus GN=Osbpl6 PE=2 SV=1
Length = 959
Score = 124 bits (311), Expect = 6e-028
Identities = 65/140 (46%), Positives = 94/140 (67%), Gaps = 4/140 (2%)
Frame = +2
Query: 296 WKMMQKYIGSDVTSMVTLPVIIFGPMTMLQKMAELMEYSHLLEMANETEDPYMRMVYASS 475
W +++ IG D+ S V++PV + P+ LQ + E MEYS LL+ A+ET+DPY RMV ++
Sbjct: 597 WNILRNNIGKDL-SKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAA 655
Query: 476 WAISVYYA--FQRTWKPFNPILGETYE-MANYNGVNFISEQVSHHPPMSAGHAENEHFTY 646
+A+S Y + F+ KPFNP+LGETYE + G F SEQVSHHPP+SA H E+++F +
Sbjct: 656 FAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVF 715
Query: 647 DCTSKLKTKFLGSSIDVYPV 706
+ K KF G S+++ PV
Sbjct: 716 WQDIRWKNKFWGKSMEILPV 735
>sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c
OS=Schizosaccharomyces pombe GN=SPBC2F12.05c PE=1 SV=2
Length = 1310
Score = 124 bits (310), Expect = 8e-028
Identities = 63/139 (45%), Positives = 93/139 (66%), Gaps = 3/139 (2%)
Frame = +2
Query: 296 WKMMQKYIGSDVTSMVTLPVIIFGPMTMLQKMAELMEYSHLLEMANETEDPYMRMVYASS 475
W +++ IG D+T M TLPV P ++LQ++AE MEY+ LL+ A+ +DPY R++Y ++
Sbjct: 939 WGILKGMIGKDMTKM-TLPVSFNEPTSLLQRVAEDMEYTELLDQASHNKDPYQRILYVAA 997
Query: 476 WAISVYYA-FQRTWKPFNPILGETYEMAN-YNGVNFISEQVSHHPPMSAGHAENEHFTYD 649
+A S Y + R KPFNP+LGETYE + G FI EQVSHHPP+ A ++E+ ++ Y
Sbjct: 998 FAASEYASTLNRVAKPFNPLLGETYEFCHPQRGFRFIVEQVSHHPPVGAAYSESANWKYY 1057
Query: 650 CTSKLKTKFLGSSIDVYPV 706
S +K+KF G S D+ P+
Sbjct: 1058 GESSVKSKFYGKSFDISPL 1076
>sp|Q9BZF2|OSBL7_HUMAN Oxysterol-binding protein-related protein 7 OS=Homo
sapiens GN=OSBPL7 PE=2 SV=1
Length = 842
Score = 123 bits (308), Expect = 1e-027
Identities = 65/140 (46%), Positives = 93/140 (66%), Gaps = 4/140 (2%)
Frame = +2
Query: 296 WKMMQKYIGSDVTSMVTLPVIIFGPMTMLQKMAELMEYSHLLEMANETEDPYMRMVYASS 475
W +++ IG D+ S V++PV + P+ LQ++ E +EYS LL+ A+ DP RMVY ++
Sbjct: 480 WNILRNNIGKDL-SKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAA 538
Query: 476 WAISVYYA--FQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAENEHFTY 646
+A+S Y + + KPFNP+LGETYE + G FISEQVSHHPP+SA HAE+E+F +
Sbjct: 539 FAVSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFAF 598
Query: 647 DCTSKLKTKFLGSSIDVYPV 706
K K KF G S+++ PV
Sbjct: 599 WQDMKWKNKFWGKSLEIVPV 618
>sp|Q9H4L5|OSBL3_HUMAN Oxysterol-binding protein-related protein 3 OS=Homo
sapiens GN=OSBPL3 PE=1 SV=1
Length = 887
Score = 117 bits (292), Expect = 1e-025
Identities = 61/140 (43%), Positives = 90/140 (64%), Gaps = 4/140 (2%)
Frame = +2
Query: 296 WKMMQKYIGSDVTSMVTLPVIIFGPMTMLQKMAELMEYSHLLEMANETEDPYMRMVYASS 475
W +++ IG D+ S V +PV + P+ LQ++ E +EYS LL+ A + P RMVY ++
Sbjct: 529 WNILRNNIGKDL-SKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAA 587
Query: 476 WAISVYYA--FQRTWKPFNPILGETYE-MANYNGVNFISEQVSHHPPMSAGHAENEHFTY 646
+AIS Y + ++ KPFNP+LGETYE + G F SEQVSHHPP+SA HAE+ +F +
Sbjct: 588 FAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHAESRNFVF 647
Query: 647 DCTSKLKTKFLGSSIDVYPV 706
+ K KF G S+++ P+
Sbjct: 648 WQDVRWKNKFWGKSMEIVPI 667
>sp|Q9DBS9|OSBL3_MOUSE Oxysterol-binding protein-related protein 3 OS=Mus
musculus GN=Osbpl3 PE=1 SV=1
Length = 855
Score = 117 bits (292), Expect = 1e-025
Identities = 61/140 (43%), Positives = 90/140 (64%), Gaps = 4/140 (2%)
Frame = +2
Query: 296 WKMMQKYIGSDVTSMVTLPVIIFGPMTMLQKMAELMEYSHLLEMANETEDPYMRMVYASS 475
W +++ IG D+ S V +PV + P+ LQ++ E +EYS LL+ A+ P RMVY ++
Sbjct: 497 WSILRNNIGKDL-SKVAMPVELNEPLNTLQRLCEELEYSELLDKASRIPSPLERMVYVAA 555
Query: 476 WAISVYYA--FQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAENEHFTY 646
+AIS Y + F+ KPFNP+LGETYE + G F +EQVSHHPP+SA HAE+ +F +
Sbjct: 556 FAISAYASSYFRAGSKPFNPVLGETYECIRQDKGFQFFAEQVSHHPPISACHAESGNFVF 615
Query: 647 DCTSKLKTKFLGSSIDVYPV 706
+ K KF G S+++ P+
Sbjct: 616 WQDVRWKNKFWGKSMEIVPI 635
>sp|Q9BXW6|OSBL1_HUMAN Oxysterol-binding protein-related protein 1 OS=Homo
sapiens GN=OSBPL1A PE=1 SV=2
Length = 950
Score = 112 bits (280), Expect = 3e-024
Identities = 61/140 (43%), Positives = 91/140 (65%), Gaps = 5/140 (3%)
Frame = +2
Query: 296 WKMMQKYIGSDVTSMVTLPVIIFGPMTMLQKMAELMEYSHLLEMANETEDPYMRMVYASS 475
W +++K IG ++ S +T+PVI P++ LQ++ E ME+++L+ A+ DP RM ++
Sbjct: 550 WSILRKCIGMEL-SKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAA 608
Query: 476 WAIS-VYYAFQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAE--NEHFT 643
+A+S V ++RT KPFNP+LGETYE+ + G ISEQVSHHPP+SA HAE N F
Sbjct: 609 FAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFI 668
Query: 644 YDCTSKLKTKFLGSSIDVYP 703
+ + K KF G S++ P
Sbjct: 669 FHGSIYPKLKFWGKSVEAEP 688
>sp|Q54ID7|OSB11_DICDI Oxysterol-binding protein 11 OS=Dictyostelium discoideum
GN=osbK PE=3 SV=1
Length = 571
Score = 109 bits (270), Expect = 4e-023
Identities = 54/142 (38%), Positives = 85/142 (59%), Gaps = 1/142 (0%)
Frame = +2
Query: 278 EERDGYWKMMQKYIGSDVTSMVTLPVIIFGPMTMLQKMAELMEYSHLLEMANETEDPYMR 457
E++ WK + +G D S+V+LPV F P+T+L+ E + + L+E A+ D R
Sbjct: 88 EDKKSLWKKVGGLVGKDPMSLVSLPVYFFEPLTVLECQLEPLRFVELIEKASTCSDSIDR 147
Query: 458 MVYASSWAISVYYAFQRTWKPFNPILGETYEMANYNG-VNFISEQVSHHPPMSAGHAENE 634
++Y +++ I+V+ ++ RT KPFNP+LGET+E + G EQVSHHPP+ +E
Sbjct: 148 LMYLTAFNIAVFSSYTRTAKPFNPLLGETFEYIDKQGRYKSFCEQVSHHPPIGIAQTTSE 207
Query: 635 HFTYDCTSKLKTKFLGSSIDVY 700
F S + TKF G+S+DV+
Sbjct: 208 IFDLQQESWITTKFWGNSLDVF 229
>sp|Q9H1P3|OSBL2_HUMAN Oxysterol-binding protein-related protein 2 OS=Homo
sapiens GN=OSBPL2 PE=1 SV=1
Length = 480
Score = 105 bits (261), Expect = 4e-022
Identities = 61/160 (38%), Positives = 96/160 (60%), Gaps = 14/160 (8%)
Frame = +2
Query: 296 WKMMQKYIGSDVTSMVTLPVIIFGPMTMLQKMAELMEYSHLLEMANETEDPYMRMVYASS 475
W +++K +G ++ S +T+P+ P++ LQ++ E ME+ +L+ A+ P RM ++
Sbjct: 77 WTILKKCVGLEL-SKITMPIAFNEPLSFLQRITEYMEHVYLIHRASCQPQPLERMQSVAA 135
Query: 476 WAIS-VYYAFQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAE--NEHFT 643
+A+S V ++RT KPFNP+LGETYE+ + G FISEQVSHHPP+SA H+E N F
Sbjct: 136 FAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFHSEGLNHDFL 195
Query: 644 YDCTSKLKTKFLGSSIDVYPVRKDEGDTQRDGVVLDLVLH 763
+ + K KF G S++ P R + L+L+ H
Sbjct: 196 FHGSIYPKLKFWGKSVEAEP---------RGTITLELLKH 226
>sp|P35845|OSH1_YEAST Oxysterol-binding protein homolog 1 OS=Saccharomyces
cerevisiae GN=OSH1 PE=1 SV=4
Length = 1188
Score = 103 bits (256), Expect = 2e-021
Identities = 59/157 (37%), Positives = 94/157 (59%), Gaps = 9/157 (5%)
Frame = +2
Query: 233 TEDAAEEANRGRWKQEERDGYWKMMQKYIGSDVTSMVTLPVIIFGPMTMLQKMAELMEYS 412
T+ A +E NR + G W +++ +G D+T + TLPV P ++LQ+++E +EYS
Sbjct: 786 TKLALDEDNR------PKIGLWSVLKSMVGQDLTKL-TLPVSFNEPTSLLQRVSEDIEYS 838
Query: 413 HLLEMANETEDPYMRMVYASSWAISVYYA-FQRTWKPFNPILGETYEMANYNG-VNFISE 586
H+L+ A ED +RM+Y +++ S+Y + R KPFNP+LGET+E A +G F +E
Sbjct: 839 HILDQAATFEDSSLRMLYVAAFTASMYASTTNRVSKPFNPLLGETFEYARTDGQYRFFTE 898
Query: 587 QVSHHPPMSAGHAENEHFTYDCTSKLKTKFLGSSIDV 697
QVSHHPP+SA E+ + + + + F G + V
Sbjct: 899 QVSHHPPISATWTESPKWDFYGECNVDSSFNGRTFAV 935
>sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2 OS=Saccharomyces
cerevisiae GN=OSH2 PE=1 SV=1
Length = 1283
Score = 100 bits (247), Expect = 2e-020
Identities = 60/156 (38%), Positives = 92/156 (58%), Gaps = 7/156 (4%)
Frame = +2
Query: 248 EEANRGRWKQEERD----GYWKMMQKYIGSDVTSMVTLPVIIFGPMTMLQKMAELMEYSH 415
E+ R R ++ D W +++ +G D+T M TLPV P ++LQ++AE +EYS
Sbjct: 879 EDGIRKRLSMDKDDRPKISLWAVLKSMVGKDMTRM-TLPVTFNEPTSLLQRVAEDLEYSE 937
Query: 416 LLEMANETEDPYMRMVYASSWAISVYYA-FQRTWKPFNPILGETYEMANYN-GVNFISEQ 589
LL+ A ED +R +Y +++ S Y + +R KPFNP+LGET+E + + F +EQ
Sbjct: 938 LLDQAATFEDSTLRTLYVAAFTASSYASTTKRVAKPFNPLLGETFEYSRPDKQYRFFTEQ 997
Query: 590 VSHHPPMSAGHAENEHFTYDCTSKLKTKFLGSSIDV 697
VSHHPP+SA E+ + + S + TKF G S +V
Sbjct: 998 VSHHPPISATWTESPRWDFWGESFVDTKFNGRSFNV 1033
>sp|Q54PS9|OSB9_DICDI Oxysterol-binding protein 9 OS=Dictyostelium discoideum
GN=osbI PE=3 SV=1
Length = 428
Score = 72 bits (175), Expect = 4e-012
Identities = 39/100 (39%), Positives = 60/100 (60%), Gaps = 2/100 (2%)
Frame = +2
Query: 320 GSDVTSMVTLPVIIFGPMTMLQKMAELMEYSHL-LEMANETEDPYMRMVYASSWAISVYY 496
G ++TS LP+ +F + L+K+ + M + L L+ A ET DP RM +S+ +S +
Sbjct: 102 GKELTS-TCLPIELFEARSFLEKVTDTMAFGPLYLKAAAETNDPIERMKMVASFVVSGLH 160
Query: 497 AFQRTWKPFNPILGETYEMANYNGVNFISEQVSHHPPMSA 616
KPFNP+LGET+E +G + EQ+SHHPP+S+
Sbjct: 161 LTTTIAKPFNPLLGETFECDLADGSSAFCEQISHHPPISS 200
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,796,540,212
Number of Sequences: 518415
Number of Extensions: 51796540212
Number of Successful Extensions: 358348623
Number of sequences better than 0.0: 0
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