BLASTX 7.6.2

Query= UN12561 /QuerySize=1117
        (1116 letters)

Database: UniProt/SwissProt;
          518,415 sequences; 182,829,261 total letters
                                                                  Score    E
Sequences producing significant alignments:                       (bits) Value

sp|Q8GUM5|NICA_ARATH Nicastrin OS=Arabidopsis thaliana GN=At3g52...    629   1e-179
sp|Q54JT7|NICA_DICDI Nicastrin OS=Dictyostelium discoideum GN=nc...     85   7e-016

>sp|Q8GUM5|NICA_ARATH Nicastrin OS=Arabidopsis thaliana GN=At3g52640/At3g52650
        PE=2 SV=1

          Length = 676

 Score =  629 bits (1622), Expect = 1e-179
 Identities = 314/350 (89%), Positives = 328/350 (93%)
 Frame = +2

Query:    2 HSDAVTGLSDALIETVLEIGSVGKGLSGGINTFIAHKTRVSSATTMTLDALKIAQGSFAS 181
            HSDAV GLS+  IETVLEIGSVGKGLSGGINTF AHKTRVSS T MTLDALKIAQ S AS
Sbjct:  327 HSDAVAGLSNTSIETVLEIGSVGKGLSGGINTFFAHKTRVSSVTNMTLDALKIAQDSLAS 386

Query:  182 KNIKILSADKTNPGIPPSSMMAFMKKNPQTSAVVLEDFDTKFVNKFYHSHLDDLSNINSS 361
            KNIKILSAD  NPGIPPSS+MAFM+KNPQTSAVVLEDFDT FVNKFYHSHLDDLSNINSS
Sbjct:  387 KNIKILSADTANPGIPPSSLMAFMRKNPQTSAVVLEDFDTNFVNKFYHSHLDDLSNINSS 446

Query:  362 SVVAAASVVARTLYILASDSKDSSNSALGSIHVNASFVEELLACLLSCEPGLSCNLVKDY 541
            SVVAAASVVARTLYILASD+KD+SNSALGSIHVNASFVEELL CLL+CEPGLSCNLVKDY
Sbjct:  447 SVVAAASVVARTLYILASDNKDTSNSALGSIHVNASFVEELLTCLLACEPGLSCNLVKDY 506

Query:  542 ISPTNTCPGNYAGVIIGEPSSKPYLGSVGDVSRFLWNILAEKTSVQKGNTTSSCSKGTCS 721
            ISPTNTCPGNYAGVI+GEPSSKPYLG VGDVSRFLWN LA+KTSVQKGNTTS CSKG CS
Sbjct:  507 ISPTNTCPGNYAGVILGEPSSKPYLGYVGDVSRFLWNFLADKTSVQKGNTTSVCSKGVCS 566

Query:  722 KTDELCIKAESNKEGTCVVSTTRYVPAYSTRLKYADGAWTILPQNTSDAMGMVDPVWTES 901
            KTDE+CIKAESNKEGTCVVSTTRYVPAYSTRLKY DGAWTILPQN+SD+MGMVDPVWTES
Sbjct:  567 KTDEVCIKAESNKEGTCVVSTTRYVPAYSTRLKYNDGAWTILPQNSSDSMGMVDPVWTES 626

Query:  902 NWNTIGVQVYRVQHSAYDNAVLVAGITVTTLAYIGIMVAKSFITKALKQD 1051
            NW+T+ V VY VQHSAYDNAVLVAGITVTTLAYIGI+ AKS ITKALKQD
Sbjct:  627 NWDTLRVHVYTVQHSAYDNAVLVAGITVTTLAYIGILAAKSIITKALKQD 676

>sp|Q54JT7|NICA_DICDI Nicastrin OS=Dictyostelium discoideum GN=ncstn PE=3 SV=2

          Length = 659

 Score =  85 bits (209), Expect = 7e-016
 Identities = 87/356 (24%), Positives = 159/356 (44%), Gaps = 53/356 (14%)
 Frame = +2

Query:   38 IETVLEIGSVGKGLSGG--------INTFIAHKTRVSSATTMTLDALKIAQGSFASKNIK 193
            I  ++E   +G+ ++ G        I   + H    + A  + +D    +  S+ +  I+
Sbjct:  335 IYAIIEFNQIGRPVNSGKKTPNKLDIYNLVFHPNGGAGANQL-MDVFSQSTQSYENSTIQ 393

Query:  194 ILSADKTNPGIPPSSMMAFMKKNPQTSA------VVLEDFDTKFVNKFYHSHLDDLSNIN 355
                  T   +PP S M+F+K+  + SA      +V+ D D ++ N ++    D+  NIN
Sbjct:  394 FQKT--TQNELPPCSSMSFIKEINKKSAPNFIGTLVITDHDYQYNNPYFGDEQDNSGNIN 451

Query:  356 --SSSVVAAASVVARTLYILASDSKDSSNSALGSIHVNASFVEELLACLLSCEPGLSCNL 529
              +S++     V ++++ +LA  +        G++ V+  F+ E+  CL      ++CN 
Sbjct:  452 TTTSTLFDMVQVFSKSIDLLAGGN--------GTVKVDDLFIREINVCLTQ---SITCNW 500

Query:  530 VKDYIS--PTNTCPGNYAGVIIGEPSSKPYLGSVGDVSRFLWNILAEKTSVQKGNTTSSC 703
            V   +S  P N  P  Y+GV        P        +RF++  +A   +  + N T+  
Sbjct:  501 VTKLMSTFPYNPIPNFYSGVY----GVSPVNHITPIETRFIFR-MATYLTQHRTNATNCT 555

Query:  704 SKGTCSKTDELCIKAESNKEGTCVVSTTRYVPAYSTRLKY--ADGAWTILPQNTSDAMGM 877
            S   C  +  +C+    NK   C+ S T Y  A S    +  +  +WTI+  NTS     
Sbjct:  556 SDNDCDTSSSICV----NK--VCLYSNTHYHNAISLAFSFDNSKSSWTIV--NTS----- 602

Query:  878 VDPVWTESNWNTIGVQVYRVQHSAYDNAVLVAGITVTTLAYIGIMVAKSFITKALK 1045
              PV+ ESNW+   V++++V   A +   LV+G+    L+   I   K +++K  K
Sbjct:  603 -YPVFVESNWDYTTVRLFQVGSYANEIWFLVSGLIELLLSVGIIFYIKKYLSKRYK 657

  Database: UniProt/SwissProt
    Posted date:  Sat Aug 07 14:36:18 2010
  Number of letters in database: 182,829,261
  Number of sequences in database:  518,415

Lambda     K     H
   0.267   0.041    0.140
Gapped
Lambda     K     H
   0.267   0.041    0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,796,540,212
Number of Sequences: 518415
Number of Extensions: 51796540212
Number of Successful Extensions: 358348623
Number of sequences better than 0.0: 0