BLASTX 7.6.2
Query= UN12795 /QuerySize=1098
(1097 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q6GLW8|AIFM2_XENLA Apoptosis-inducing factor 2 OS=Xenopus lae... 139 3e-032
sp|B4F6I3|AIFM2_XENTR Apoptosis-inducing factor 2 OS=Xenopus tro... 138 7e-032
sp|Q54NS9|AIFA_DICDI Apoptosis-inducing factor homolog A OS=Dict... 138 1e-031
sp|Q54NS8|AIFB_DICDI Apoptosis-inducing factor homolog B OS=Dict... 135 6e-031
sp|B5FXE5|AIFM2_TAEGU Apoptosis-inducing factor 2 OS=Taeniopygia... 133 3e-030
sp|Q8BUE4|AIFM2_MOUSE Apoptosis-inducing factor 2 OS=Mus musculu... 123 3e-027
sp|A5PJM4|AIFM2_BOVIN Apoptosis-inducing factor 2 OS=Bos taurus ... 122 7e-027
sp|Q9BRQ8|AIFM2_HUMAN Apoptosis-inducing factor 2 OS=Homo sapien... 121 9e-027
>sp|Q6GLW8|AIFM2_XENLA Apoptosis-inducing factor 2 OS=Xenopus laevis GN=aifm2
PE=2 SV=1
Length = 374
Score = 139 bits (350), Expect = 3e-032
Identities = 95/298 (31%), Positives = 155/298 (52%), Gaps = 20/298 (6%)
Frame = +3
Query: 15 GRVVTSPAIDITESDVTTKDGAVIGYDYLVIATGHNDLLPKTRHEKLSQ------YQAEY 176
G+VV I++ V + + + +L+IATG N P +E +S+ Y+
Sbjct: 79 GKVV---GINLQTQLVILESNEELSFSHLIIATGSNGPFPGKFNEVISKDQAIQIYENLV 135
Query: 177 EKIVSSKSVLIVGGGPSGVELAAEIAVDFPEKKVTLVHKGPRLLEFVGEKAADKAF-DWL 353
E+I +K V++VGGG +GVE+AAE+ D+PEK+VTL+H L + + + + + L
Sbjct: 136 EEIQKAKHVVVVGGGSAGVEMAAEVKTDYPEKEVTLIHSKIALADVQLQPSVRRTVKEIL 195
Query: 354 ESKKVEVILNQ------SVDLSSASDGNKTYKTSGGETIHADCHFLCVGKPLSSRWLNGT 515
K V +IL Q V + A + + E ++ D C+G +SS +
Sbjct: 196 LRKGVRLILAQKVTNLDQVTPNVAQENMELQLDKDSEVVNCDLVLCCIGLKVSSSSYR-S 254
Query: 516 VLKDSLDGKGRVMVDEHLRVKDRKNVFAIGDITNILEMKQGYIAESHANVAVKNIKVMMS 695
L D + G ++V+++L+V+ +NV+A+GD I E K Y A HA VA N++ +
Sbjct: 255 ALGDKMAEDGSLIVNDYLQVQGHENVYAVGDCAYINEPKMAYYAGIHARVAATNVRNSLI 314
Query: 696 GGKRKKLSTYKPGSEIAIVSLGRKDSVAQFPFVTVVGCLPGLIKSKDLFVGKTRKARG 869
G K L +Y PG+ ++S+GR D V QF + C + KS+D+FV K+ K G
Sbjct: 315 G---KSLKSYIPGALSMLLSMGRNDGVGQFNGYYLGRCFVTMAKSRDIFVSKSWKEMG 369
>sp|B4F6I3|AIFM2_XENTR Apoptosis-inducing factor 2 OS=Xenopus tropicalis
GN=aifm2 PE=2 SV=1
Length = 374
Score = 138 bits (347), Expect = 7e-032
Identities = 103/303 (33%), Positives = 153/303 (50%), Gaps = 30/303 (9%)
Frame = +3
Query: 15 GRVVTSPAIDITESDVTTKDGAVIGYDYLVIATGHNDLLPKTRHEKLSQYQA--EYEKIV 188
G+VV I++ V + + + +L+IATG N P + +S+ QA YE +V
Sbjct: 79 GKVV---GINLQTQRVILESNEELQFSHLIIATGSNGPFPGKINNVISKDQAIQVYEDLV 135
Query: 189 ----SSKSVLIVGGGPSGVELAAEIAVDFPEKKVTLVHKGPRLLEF-VGEKAADKAFDWL 353
+K V++VGGG +GVE+AAE+ D+PEK+VTLVH L + + K + L
Sbjct: 136 KEIQKAKHVVVVGGGSAGVEMAAEVKTDYPEKEVTLVHSKVALADVQLQPKVRRTVKEIL 195
Query: 354 ESKKVEVILNQ------SVDLSSASDGNKTYKTSGGETIHADCHFLCVGKPLSSRWLNGT 515
SK V +IL Q V + A + E + D C G +SS + +
Sbjct: 196 LSKGVRLILAQKVTNLDQVTSNVAQENTVLQLDKNSEVVTCDLVLCCTGYKISSSSYS-S 254
Query: 516 VLKDSLDGKGRVMVDEHLRVKDRKNVFAIGDITNILEMKQGYIAESHANVAVKNIKVMMS 695
D L G ++V+++L+V+ NV+A+GD I E K Y A HA VA N++ +
Sbjct: 255 AFGDKLAEDGALIVNDYLQVQGHANVYAVGDCAYINEPKMAYYAGIHARVAATNVRNSLI 314
Query: 696 GGKRKKLSTYKPGSEIAIVSLGRKDSVAQFPFVTVVGCLPG-----LIKSKDLFVGKTRK 860
G K L TYKPG+ ++S+GR D V QF GC G + KS+D+FV K+ K
Sbjct: 315 G---KSLKTYKPGALSMLLSMGRNDGVGQFN-----GCYLGRFFVTMAKSRDIFVSKSWK 366
Query: 861 ARG 869
G
Sbjct: 367 EMG 369
>sp|Q54NS9|AIFA_DICDI Apoptosis-inducing factor homolog A OS=Dictyostelium
discoideum GN=aifA PE=3 SV=1
Length = 408
Score = 138 bits (345), Expect = 1e-031
Identities = 101/310 (32%), Positives = 161/310 (51%), Gaps = 29/310 (9%)
Frame = +3
Query: 6 LKNGRVVTSPAIDITESDVTTKDGAVIGYDYLVIATGHNDLLP-KTRHEKLS------QY 164
LKNG+ + I+I+ + V +DG + +DYLVIATG N L P K EK+S Y
Sbjct: 88 LKNGKFIYGTVIEISPTLVKLEDGKELTFDYLVIATGSNSLAPFKAPLEKISGTEIFNYY 147
Query: 165 QAEYEKIVSSKSVLIVGGGPSGVELAAEIAVDFP------EKKVTLVHKGPRLLEF-VGE 323
+ E+I +KS+LIVGGG G E+ EI +P KK+T+VH G +L+
Sbjct: 148 KDISEQIKQAKSILIVGGGSVGCEVVGEIINKYPIKNKELAKKITIVHSGNKLVSSKTNN 207
Query: 324 KAADKAFDWLESKKVEVILNQSVDLS--------SASDGN-----KTYKTSGGETIHADC 464
K + + ++ + V VILN +++ + + N KTYKT G +I +D
Sbjct: 208 KFNNLINESMKKRNVSVILNDRIEIPDDIKQCFINQTSPNFQVSLKTYKTKNGLSIESDF 267
Query: 465 HFLCVGKPLSSRWLNGTVLKDSLDGKGRVMVDEHLRVKDRKNVFAIGDITNILEMKQGYI 644
+G L+S T + ++ G++ V++ +V+ N+FAIGDIT+ E+K Y
Sbjct: 268 VIWTIGIKLNSESYK-TNFSNEINEIGQIKVNQSCQVQGYDNIFAIGDITDFDELKTTYN 326
Query: 645 AESHANVAVKNIKVMMSGGKRKKLSTYKPGSEIAIVSLGRKDSVAQFPFVTVVGC-LPGL 821
A SH N+ K IK + +G + +L+ +K I +SLG KD + Q G + +
Sbjct: 327 ALSHGNIVAKVIKDLSNGKNKNQLAKHKLLPPIISLSLGPKDGLTQINSNLNFGSFISRI 386
Query: 822 IKSKDLFVGK 851
+KS +L + +
Sbjct: 387 LKSNNLLINR 396
>sp|Q54NS8|AIFB_DICDI Apoptosis-inducing factor homolog B OS=Dictyostelium
discoideum GN=aifB PE=3 SV=1
Length = 387
Score = 135 bits (339), Expect = 6e-031
Identities = 98/310 (31%), Positives = 151/310 (48%), Gaps = 29/310 (9%)
Frame = +3
Query: 6 LKNGRVVTSPAIDITESDVTTKDGAVIGYDYLVIATGHNDLLP-------KTRHEKLSQY 164
LKNG+ + I+I+ + +DG + +DYLVIATG N L P K+ E L+ +
Sbjct: 66 LKNGKFIFGTVIEISPTLAKLEDGQELTFDYLVIATGSNSLAPFKAPLEKKSSSEILNYF 125
Query: 165 QAEYEKIVSSKSVLIVGGGPSGVELAAEIAVDFP------EKKVTLVHKGPRLLE-FVGE 323
Q ++I +KS+LIVGGG EL +EI +P KK+T+VH G +L+ + +
Sbjct: 126 QNFSQQIKQAKSILIVGGGAVACELVSEIVEKYPVKDSELVKKITIVHSGSKLVNPKMND 185
Query: 324 KAADKAFDWLESKKVEVILNQSVDLSSASDGN-------------KTYKTSGGETIHADC 464
K + ++ + VEVILN + + N + Y T G I AD
Sbjct: 186 KFTNVVSKAMKKRNVEVILNDRITMPDEIKANLLNQTSPNIQISSQNYTTEKGVPIQADL 245
Query: 465 HFLCVGKPLSSRWLNGTVLKDSLDGKGRVMVDEHLRVKDRKNVFAIGDITNILEMKQGYI 644
VG +S + + ++ G++ V+ +V+ NVFAIGD T+ E K Y
Sbjct: 246 IIWTVGIKTNSESYQ-SHFSNVINESGQLKVNLSCQVQGYNNVFAIGDCTDFDEFKTAYN 304
Query: 645 AESHANVAVKNIKVMMSGGKRKKLSTYKPGSEIAIVSLGRKDSVAQF-PFVTVVGCLPGL 821
A HA +A K I + G KL+ +K I +SLG +D + Q P + + +
Sbjct: 305 AGYHAAIAAKAIDALSKGKSNDKLAKHKVSGPILSLSLGPQDGITQISPTMCLGSFATKM 364
Query: 822 IKSKDLFVGK 851
IKSK LF+ +
Sbjct: 365 IKSKSLFIDR 374
>sp|B5FXE5|AIFM2_TAEGU Apoptosis-inducing factor 2 OS=Taeniopygia guttata
GN=AIFM2 PE=2 SV=1
Length = 373
Score = 133 bits (333), Expect = 3e-030
Identities = 95/300 (31%), Positives = 149/300 (49%), Gaps = 25/300 (8%)
Frame = +3
Query: 15 GRVVTSPAIDITESDVTTKDGAVIGYDYLVIATGHNDLLPKTRHE------KLSQYQAEY 176
G+VV AID V DG + Y +L++ATG + P ++ + Y+
Sbjct: 79 GKVV---AIDPGRQQVVLSDGEELHYSHLILATGSDGPFPGKFNQVIDMESAIQTYEDMV 135
Query: 177 EKIVSSKSVLIVGGGPSGVELAAEIAVDFPEKKVTLVHKG---------PRLLEFVGEKA 329
++I S+ +L+VGGG +GVE+AAEI ++P K++ L+H P + + V E
Sbjct: 136 KEIEKSQRILVVGGGAAGVEMAAEIKTEYPGKEIILIHSKTALADVELLPSVRQVVKEIL 195
Query: 330 ADKAFDWLESKKVEVILNQSVDLSSASDGNKTYKTSGGETIHADCHFLCVGKPLSSRWLN 509
K L S+KV I N + + +T G + D LC G ++S
Sbjct: 196 LRKGVRLLLSEKVSDIENLR---PNQFQKDMVVRTEKGTEVVVDMVVLCTGIKINSS-AY 251
Query: 510 GTVLKDSLDGKGRVMVDEHLRVKDRKNVFAIGDITNILEMKQGYIAESHANVAVKNIKVM 689
D + G + V++HL+++ +N++AIGD ++ E K Y A HANV V NI
Sbjct: 252 AAAFGDKMASDGALKVNKHLQLEGYENIYAIGDCADLKEPKMAYHAGLHANVVVTNI--- 308
Query: 690 MSGGKRKKLSTYKPGSEIAIVSLGRKDSVAQFPFVTVVGCLPGLIKSKDLFVGKTRKARG 869
++ +K L TY+PGS ++S+GR D V Q V L + KS+DLFV K+ + G
Sbjct: 309 INSLTQKPLKTYEPGSLTFLLSMGRNDGVGQVNGYYVGRLLVTIAKSRDLFVSKSWRTMG 368
>sp|Q8BUE4|AIFM2_MOUSE Apoptosis-inducing factor 2 OS=Mus musculus GN=Aifm2 PE=2
SV=1
Length = 373
Score = 123 bits (307), Expect = 3e-027
Identities = 91/304 (29%), Positives = 151/304 (49%), Gaps = 27/304 (8%)
Frame = +3
Query: 15 GRVVTSPAIDITESDVTTKDGAVIGYDYLVIATGHNDLLPKTRHE------KLSQYQAEY 176
G+V+ ID+ V + G + + +L++ATG P +E + Y+
Sbjct: 80 GKVI---GIDLKNRMVLLQGGEALPFSHLILATGSTGPFPGKFNEVSCQQAAIQAYEDMV 136
Query: 177 EKIVSSKSVLIVGGGPSGVELAAEIAVDFPEKKVTLVHK-----GPRLLEFVGEKAADKA 341
++I S+ +++VGGG +GVE+AAEI ++PEK+VTL+H LL V ++
Sbjct: 137 KQIQRSQFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSRVPLADKELLPCVRQEVK--- 193
Query: 342 FDWLESKKVEVILNQSVDLSSASDGNK-----TYKTSGGETIHADCHFLCVGKPLSSRWL 506
+ L K V+++L++ V N+ +T G + + +C G ++S
Sbjct: 194 -EILLRKGVQLLLSERVSNLEELPRNEYREYIKVETDKGTEVATNMVIVCNGIKINSSAY 252
Query: 507 NGTVLKDSLDGKGRVMVDEHLRVKDRKNVFAIGDITNILEMKQGYIAESHANVAVKNIKV 686
+ + L G + V+E L+V+ N++AIGD + E K Y A HANVAV NI
Sbjct: 253 R-SAFESRLASNGALKVNEFLQVEGYSNIYAIGDCADTKEPKMAYHAGLHANVAVANI-- 309
Query: 687 MMSGGKRKKLSTYKPGSEIAIVSLGRKDSVAQFPFVTVVGCLPGLIKSKDLFVGKTRKAR 866
++ K++ L YKPG+ ++S+GR D V Q V + L KS+DL + + K
Sbjct: 310 -VNSMKQRPLKAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLAKSRDLLISTSWKTM 368
Query: 867 GLSP 878
SP
Sbjct: 369 RQSP 372
>sp|A5PJM4|AIFM2_BOVIN Apoptosis-inducing factor 2 OS=Bos taurus GN=AIFM2 PE=2
SV=1
Length = 373
Score = 122 bits (304), Expect = 7e-027
Identities = 81/248 (32%), Positives = 133/248 (53%), Gaps = 10/248 (4%)
Frame = +3
Query: 153 LSQYQAEYEKIVSSKSVLIVGGGPSGVELAAEIAVDFPEKKVTLVHKGPRLLEF-VGEKA 329
+ Y+ ++ S+S+++VGGG +GVE+AAEI ++PEK+VTL+H L + +
Sbjct: 129 IQAYEDMVTQVQRSQSIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSKMALADTELLPCV 188
Query: 330 ADKAFDWLESKKVEVILNQSVDLSSASDGNK-----TYKTSGGETIHADCHFLCVGKPLS 494
+ + L K V+++L++ V A N+ +T G + A+ +C G ++
Sbjct: 189 RQEVKEILLRKGVQLLLSERVSNLEALPVNERRECIKVQTDKGTEVDANLVIVCNGIKIN 248
Query: 495 SRWLNGTVLKDSLDGKGRVMVDEHLRVKDRKNVFAIGDITNILEMKQGYIAESHANVAVK 674
S + D L G + V+E+L+V+ +++AIGD ++ E K Y A HANVAV
Sbjct: 249 SAAYR-SAFGDRLASNGALRVNEYLQVEGYSHIYAIGDCADVREPKMAYHASLHANVAVA 307
Query: 675 NIKVMMSGGKRKKLSTYKPGSEIAIVSLGRKDSVAQFPFVTVVGCLPGLIKSKDLFVGKT 854
NI ++ K++ L TYKPGS ++++GR D V Q V + L KS+DL V +
Sbjct: 308 NI---VNSMKQRPLKTYKPGSLTFLLAMGRNDGVGQISGFYVGRLMVRLAKSRDLLVSTS 364
Query: 855 RKARGLSP 878
K SP
Sbjct: 365 WKTMKQSP 372
Score = 71 bits (173), Expect = 1e-011
Identities = 37/90 (41%), Positives = 58/90 (64%), Gaps = 6/90 (6%)
Frame = +3
Query: 39 IDITESDVTTKDGAVIGYDYLVIATGHNDLLPKTRHEKLSQYQA--EYEKIVS----SKS 200
ID+ V +DG + + +L++ATG L P ++ SQ A YE +V+ S+S
Sbjct: 85 IDLKNQTVLLEDGQALPFSHLILATGSTGLFPGKFNQVSSQQMAIQAYEDMVTQVQRSQS 144
Query: 201 VLIVGGGPSGVELAAEIAVDFPEKKVTLVH 290
+++VGGG +GVE+AAEI ++PEK+VTL+H
Sbjct: 145 IVVVGGGSAGVEMAAEIKTEYPEKEVTLIH 174
>sp|Q9BRQ8|AIFM2_HUMAN Apoptosis-inducing factor 2 OS=Homo sapiens GN=AIFM2 PE=2
SV=1
Length = 373
Score = 121 bits (303), Expect = 9e-027
Identities = 79/248 (31%), Positives = 129/248 (52%), Gaps = 10/248 (4%)
Frame = +3
Query: 153 LSQYQAEYEKIVSSKSVLIVGGGPSGVELAAEIAVDFPEKKVTLVHKGPRLLE-FVGEKA 329
+ Y+ ++ S+ +++VGGG +GVE+AAEI ++PEK+VTL+H L + +
Sbjct: 129 IQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALADKELLPSV 188
Query: 330 ADKAFDWLESKKVEVILNQSVDLSSASDGNK-----TYKTSGGETIHADCHFLCVGKPLS 494
+ + L K V+++L++ V N+ +T G + + LC G ++
Sbjct: 189 RQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVATNLVILCTGIKIN 248
Query: 495 SRWLNGTVLKDSLDGKGRVMVDEHLRVKDRKNVFAIGDITNILEMKQGYIAESHANVAVK 674
S + L G + V+EHL+V+ NV+AIGD ++ K Y+A HAN+AV
Sbjct: 249 SSAYR-KAFESRLASSGALRVNEHLQVEGHSNVYAIGDCADVRTPKMAYLAGLHANIAVA 307
Query: 675 NIKVMMSGGKRKKLSTYKPGSEIAIVSLGRKDSVAQFPFVTVVGCLPGLIKSKDLFVGKT 854
NI ++ K++ L YKPG+ ++S+GR D V Q V + L KS+DLFV +
Sbjct: 308 NI---VNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLTKSRDLFVSTS 364
Query: 855 RKARGLSP 878
K SP
Sbjct: 365 WKTMRQSP 372
Score = 63 bits (152), Expect = 3e-009
Identities = 32/90 (35%), Positives = 53/90 (58%), Gaps = 6/90 (6%)
Frame = +3
Query: 39 IDITESDVTTKDGAVIGYDYLVIATGHNDLLPKTRHEKLSQ------YQAEYEKIVSSKS 200
ID+ V + G + + +L++ATG P +E SQ Y+ ++ S+
Sbjct: 85 IDLKNQMVLLQGGEALPFSHLILATGSTGPFPGKFNEVSSQQAAIQAYEDMVRQVQRSRF 144
Query: 201 VLIVGGGPSGVELAAEIAVDFPEKKVTLVH 290
+++VGGG +GVE+AAEI ++PEK+VTL+H
Sbjct: 145 IVVVGGGSAGVEMAAEIKTEYPEKEVTLIH 174
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,796,540,212
Number of Sequences: 518415
Number of Extensions: 51796540212
Number of Successful Extensions: 358348623
Number of sequences better than 0.0: 0
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