BLASTX 7.6.2
Query= UN13077 /QuerySize=1353
(1352 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5R6D1|CATB_PONAB Cathepsin B OS=Pongo abelii GN=CTSB PE=2 SV=1 293 3e-078
sp|P07858|CATB_HUMAN Cathepsin B OS=Homo sapiens GN=CTSB PE=1 SV=3 292 5e-078
sp|P10605|CATB_MOUSE Cathepsin B OS=Mus musculus GN=Ctsb PE=1 SV=2 281 9e-075
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase OS=Sch... 270 2e-071
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase OS=Sch... 270 2e-071
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase OS=Caenorh... 247 1e-064
sp|Q54QD9|CTSB_DICDI Cathepsin B OS=Dictyostelium discoideum GN=... 232 5e-060
sp|Q4R5M2|CATB_MACFA Cathepsin B OS=Macaca fascicularis GN=CTSB ... 168 1e-040
sp|A1E295|CATB_PIG Cathepsin B OS=Sus scrofa GN=CTSB PE=1 SV=1 164 1e-039
sp|P00787|CATB_RAT Cathepsin B OS=Rattus norvegicus GN=Ctsb PE=1... 164 1e-039
sp|P07688|CATB_BOVIN Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5 162 6e-039
sp|P43508|CPR4_CAEEL Cathepsin B-like cysteine proteinase 4 OS=C... 161 1e-038
sp|P43233|CATB_CHICK Cathepsin B OS=Gallus gallus GN=CTSB PE=2 SV=1 157 2e-037
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 OS=C... 151 1e-035
sp|Q06544|CYSP3_OSTOS Cathepsin B-like cysteine proteinase 3 (Fr... 150 3e-035
sp|P19092|CYSP1_HAECO Cathepsin B-like cysteine proteinase 1 OS=... 144 1e-033
sp|P25793|CYSP2_HAECO Cathepsin B-like cysteine proteinase 2 OS=... 144 2e-033
sp|P92133|CATB3_GIALA Cathepsin B-like CP3 OS=Giardia lamblia GN... 121 1e-026
>sp|Q5R6D1|CATB_PONAB Cathepsin B OS=Pongo abelii GN=CTSB PE=2 SV=1
Length = 339
Score = 293 bits (748), Expect = 3e-078
Identities = 149/318 (46%), Positives = 198/318 (62%), Gaps = 30/318 (9%)
Frame = -1
Query: 1169 LQEEIVKKVNEHPNAGWKAAINDRFSNATVAEFKRLLGVKPTPKKLLLGVPV----VSHD 1002
L +E+V VN+ N W+A N F N V+ K+L G LG P V
Sbjct: 26 LSDELVNYVNKR-NTTWQAGHN--FYNVDVSYLKKLCGT-------FLGGPKPPQRVMFT 75
Query: 1001 QSLKLPKSFDARTHWPQCTSIGKILDQGHCGSCWAFGAVESLSDRFCIQFGMNITLSVN- 825
+ LKLP+SFDAR WPQC +I +I DQG CGSCWAFGAVE++SDR CI ++++ V+
Sbjct: 76 EDLKLPESFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSA 135
Query: 824 -DLLACCGFRCGDGCDGGYPISAWQYFSYSGVVT-------EECDPYF-----DQTGCSH 684
DLL CCG CGDGC+GGYP AW +++ G+V+ C PY S
Sbjct: 136 EDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSR 195
Query: 683 PGCEPAYNTPQCLRKC-VGRNQLWSESKHYSINTYVVESNPQDIMAEIYKNGPVEVSFTV 507
P C +TP+C + C G + + + KHY N+Y V ++ +DIMAEIYKNGPVE +F+V
Sbjct: 196 PPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSERDIMAEIYKNGPVEGAFSV 255
Query: 506 YEDFAHYKSGVYKHITGSNIGGHAVKLIGWGTTDDGEDYWLLANQWNRSWGDDGYFMIRR 327
Y DF YKSGVY+H+TG +GGHA++++GWG ++G YWL+AN WN WGD+G+F I R
Sbjct: 256 YSDFLLYKSGVYQHVTGEMMGGHAIRILGWG-VENGTPYWLVANSWNTDWGDNGFFKILR 314
Query: 326 GTNECGIEDEPVGGLPST 273
G + CGIE E V G+P T
Sbjct: 315 GQDHCGIESEVVAGIPRT 332
>sp|P07858|CATB_HUMAN Cathepsin B OS=Homo sapiens GN=CTSB PE=1 SV=3
Length = 339
Score = 292 bits (746), Expect = 5e-078
Identities = 149/318 (46%), Positives = 197/318 (61%), Gaps = 30/318 (9%)
Frame = -1
Query: 1169 LQEEIVKKVNEHPNAGWKAAINDRFSNATVAEFKRLLGVKPTPKKLLLGVPV----VSHD 1002
L +E+V VN+ N W+A N F N ++ KRL G LG P V
Sbjct: 26 LSDELVNYVNKR-NTTWQAGHN--FYNVDMSYLKRLCGT-------FLGGPKPPQRVMFT 75
Query: 1001 QSLKLPKSFDARTHWPQCTSIGKILDQGHCGSCWAFGAVESLSDRFCIQFGMNITLSVN- 825
+ LKLP SFDAR WPQC +I +I DQG CGSCWAFGAVE++SDR CI ++++ V+
Sbjct: 76 EDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSA 135
Query: 824 -DLLACCGFRCGDGCDGGYPISAWQYFSYSGVVT-------EECDPYF-----DQTGCSH 684
DLL CCG CGDGC+GGYP AW +++ G+V+ C PY S
Sbjct: 136 EDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSR 195
Query: 683 PGCEPAYNTPQCLRKC-VGRNQLWSESKHYSINTYVVESNPQDIMAEIYKNGPVEVSFTV 507
P C +TP+C + C G + + + KHY N+Y V ++ +DIMAEIYKNGPVE +F+V
Sbjct: 196 PPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSV 255
Query: 506 YEDFAHYKSGVYKHITGSNIGGHAVKLIGWGTTDDGEDYWLLANQWNRSWGDDGYFMIRR 327
Y DF YKSGVY+H+TG +GGHA++++GWG ++G YWL+AN WN WGD+G+F I R
Sbjct: 256 YSDFLLYKSGVYQHVTGEMMGGHAIRILGWG-VENGTPYWLVANSWNTDWGDNGFFKILR 314
Query: 326 GTNECGIEDEPVGGLPST 273
G + CGIE E V G+P T
Sbjct: 315 GQDHCGIESEVVAGIPRT 332
>sp|P10605|CATB_MOUSE Cathepsin B OS=Mus musculus GN=Ctsb PE=1 SV=2
Length = 339
Score = 281 bits (718), Expect = 9e-075
Identities = 141/320 (44%), Positives = 194/320 (60%), Gaps = 34/320 (10%)
Frame = -1
Query: 1169 LQEEIVKKVNEHPNAGWKAAINDRFSNATVAEFKRLLGVKPTPKKLLLGVPV----VSHD 1002
L ++++ +N+ N W+A N F N ++ K+L G +LG P V+
Sbjct: 26 LSDDLINYINKQ-NTTWQAGRN--FYNVDISYLKKLCGT-------VLGGPKLPGRVAFG 75
Query: 1001 QSLKLPKSFDARTHWPQCTSIGKILDQGHCGSCWAFGAVESLSDRFCIQFG--MNITLSV 828
+ + LP++FDAR W C +IG+I DQG CGSCWAFGAVE++SDR CI +N+ +S
Sbjct: 76 EDIDLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSA 135
Query: 827 NDLLACCGFRCGDGCDGGYPISAWQYFSYSGVVTEECDPYFDQTGC-------------- 690
DLL CCG +CGDGC+GGYP AW +++ G+V+ Y GC
Sbjct: 136 EDLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSG--GVYNSHVGCLPYTIPPCEHHVNG 193
Query: 689 SHPGCEPAYNTPQCLRKC-VGRNQLWSESKHYSINTYVVESNPQDIMAEIYKNGPVEVSF 513
S P C +TP+C + C G + + E KH+ +Y V ++ ++IMAEIYKNGPVE +F
Sbjct: 194 SRPPCTGEGDTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGAF 253
Query: 512 TVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGTTDDGEDYWLLANQWNRSWGDDGYFMI 333
TV+ DF YKSGVYKH G +GGHA++++GWG ++G YWL AN WN WGD+G+F I
Sbjct: 254 TVFSDFLTYKSGVYKHEAGDMMGGHAIRILGWG-VENGVPYWLAANSWNLDWGDNGFFKI 312
Query: 332 RRGTNECGIEDEPVGGLPST 273
RG N CGIE E V G+P T
Sbjct: 313 LRGENHCGIESEIVAGIPRT 332
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase OS=Schistosoma
mansoni PE=2 SV=1
Length = 340
Score = 270 bits (690), Expect = 2e-071
Identities = 139/312 (44%), Positives = 191/312 (61%), Gaps = 20/312 (6%)
Frame = -1
Query: 1169 LQEEIVKKVNEHPNAGWKAAINDRFSNATVAEFKRLLGVKPTPKKLLLGVPVVSH-DQSL 993
L ++I+ +NEHPNAGW+A ++RF + A ++ + P P V H D ++
Sbjct: 29 LSDDIISYINEHPNAGWRAEKSNRFHSLDDARI-QMGARREEPDLRRKRRPTVDHNDWNV 87
Query: 992 KLPKSFDARTHWPQCTSIGKILDQGHCGSCWAFGAVESLSDRFCIQFG--MNITLSVNDL 819
++P +FD+R WP C SI I DQ CGSCW+FGAVE++SDR CIQ G N+ LS DL
Sbjct: 88 EIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDL 147
Query: 818 LACCGFRCGDGCDGGYPISAWQYFSYSGVVTEE-------CDPY-----FDQTGCSHPGC 675
L CC CG GC+GG AW Y+ G+VT C+PY T +P C
Sbjct: 148 LTCCE-SCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPC 206
Query: 674 -EPAYNTPQCLRKCVGRNQL-WSESKHYSINTYVVESNPQDIMAEIYKNGPVEVSFTVYE 501
YNTP+C + C + + +++ KH ++Y V+++ + I EI K GPVE SFTVYE
Sbjct: 207 GSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYE 266
Query: 500 DFAHYKSGVYKHITGSNIGGHAVKLIGWGTTDDGEDYWLLANQWNRSWGDDGYFMIRRGT 321
DF +YKSG+YKHITG +GGHA+++IGWG ++ YWL+AN WN WG++GYF I RG
Sbjct: 267 DFLNYKSGIYKHITGEALGGHAIRIIGWG-VENKTPYWLIANSWNEDWGENGYFRIVRGR 325
Query: 320 NECGIEDEPVGG 285
+EC IE E + G
Sbjct: 326 DECSIESEVIAG 337
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase OS=Schistosoma
japonicum GN=CATB PE=2 SV=1
Length = 342
Score = 270 bits (689), Expect = 2e-071
Identities = 138/317 (43%), Positives = 188/317 (59%), Gaps = 22/317 (6%)
Frame = -1
Query: 1169 LQEEIVKKVNEHPNAGWKAAINDRFSNATVAEFKRLLGVKPTPKKLLLG--VPVVSHDQS 996
L +E++ +NEHP+AGWKA +DRF + A L+G + ++ V HD +
Sbjct: 30 LSDEMISFINEHPDAGWKADKSDRFHSLDDARI--LMGARKEDAEMKRNRRPTVDHHDLN 87
Query: 995 LKLPKSFDARTHWPQCTSIGKILDQGHCGSCWAFGAVESLSDRFCIQF--GMNITLSVND 822
+++P FD+R WP C SI +I DQ CGSCWAFGAVE+++DR CIQ G + LS D
Sbjct: 88 VEIPSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALD 147
Query: 821 LLACCGFRCGDGCDGGYPISAWQYFSYSGVVT-------EECDPY-----FDQTGCSHPG 678
L++CC CGDGC GG+P AW Y+ G+VT C PY T +P
Sbjct: 148 LISCCK-DCGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPA 206
Query: 677 C-EPAYNTPQCLRKC-VGRNQLWSESKHYSINTYVVESNPQDIMAEIYKNGPVEVSFTVY 504
C Y TPQC + C G + + KHY +Y V++N + I +I GPVE +F VY
Sbjct: 207 CGTKIYKTPQCKQTCQKGYKTPYEQDKHYGDESYNVQNNEKVIQRDIMMYGPVEAAFDVY 266
Query: 503 EDFAHYKSGVYKHITGSNIGGHAVKLIGWGTTDDGEDYWLLANQWNRSWGDDGYFMIRRG 324
EDF +YKSG+Y+H+TGS +GGHA+++IGWG + YWL+AN WN WG+ G F + RG
Sbjct: 267 EDFLNYKSGIYRHVTGSIVGGHAIRIIGWG-VEKRTPYWLIANSWNEDWGEKGLFRMVRG 325
Query: 323 TNECGIEDEPVGGLPST 273
+EC IE + V GL T
Sbjct: 326 RDECSIESDVVAGLIKT 342
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase OS=Caenorhabditis elegans
GN=cpr-1 PE=1 SV=2
Length = 329
Score = 247 bits (630), Expect = 1e-064
Identities = 119/244 (48%), Positives = 153/244 (62%), Gaps = 12/244 (4%)
Frame = -1
Query: 989 LPKSFDARTHWPQCTSIGKILDQGHCGSCWAFGAVESLSDRFCIQF--GMNITLSVNDLL 816
+P +FD+RT W +C SI I DQ CGSCWAFGA E +SDR CI+ +S +DLL
Sbjct: 85 VPATFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLL 144
Query: 815 ACCGFRCGDGCDGGYPISAWQYFSYSGVVT------EECDPYFDQTGCSHPGCEPAYNTP 654
+CCG CG+GC+GGYPI A +++ GVVT C PY C+ C P TP
Sbjct: 145 SCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDYHGAGCKPY-PIAPCTSGNC-PESKTP 202
Query: 653 QCLRKC-VGRNQLWSESKHYSINTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSG 477
C C G + +++ KH+ ++ Y V N I AEIY NGPVE +F+VYEDF YKSG
Sbjct: 203 SCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYANGPVEAAFSVYEDFYKYKSG 262
Query: 476 VYKHITGSNIGGHAVKLIGWGTTDDGEDYWLLANQWNRSWGDDGYFMIRRGTNECGIEDE 297
VYKH G +GGHA+K+IGWG T+ G YWL+AN W +WG+ G+F I RG ++CGIE
Sbjct: 263 VYKHTAGKYLGGHAIKIIGWG-TESGSPYWLVANSWGVNWGESGFFKIYRGDDQCGIESA 321
Query: 296 PVGG 285
V G
Sbjct: 322 VVAG 325
>sp|Q54QD9|CTSB_DICDI Cathepsin B OS=Dictyostelium discoideum GN=ctsB PE=3 SV=1
Length = 311
Score = 232 bits (591), Expect = 5e-060
Identities = 126/281 (44%), Positives = 170/281 (60%), Gaps = 16/281 (5%)
Frame = -1
Query: 1121 WKAAINDRFSNATVAEFKRLLGVKPTPKKLLLGVPVVSHDQ-SLKLPKSFDARTHWPQCT 945
W D+F N V + LLG K +P + L + S+D +++P SF+A+T+WP CT
Sbjct: 39 WVEEQTDQFDNIKVGQ---LLGFKRSPNRPKL--QIKSYDPLGVQIPTSFNAQTNWPNCT 93
Query: 944 SIGKILDQGHCGSCWAFGAVESLSDRFCIQFGMNITLSVNDLLACCGFRCGDGCDGGYPI 765
+I +I +Q CGSCWAFGA ES +DR CI N+ LS D++ C +GC+GG
Sbjct: 94 TISQIQNQARCGSCWAFGATESATDRLCIHNNENVQLSFMDMVTC--DETDNGCEGGDAF 151
Query: 764 SAWQYFSYSGVVTEECDPYFDQTGC--SHPGCEPAYNTPQCLRKCVGRNQL-WSESKHYS 594
SAW + G V+EEC PY T C + C NTP C ++C + L +S+ KH
Sbjct: 152 SAWNWLRKQGAVSEECLPYTIPT-CPPAQQPCLNFVNTPSCTKECQSNSSLIYSQDKHKM 210
Query: 593 INTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWG 414
Y +S+ + IM EI NGPVE FTV+EDF YKSGVY H TG ++GGH VKL+G+G
Sbjct: 211 AKIYSFDSD-EAIMQEIVTNGPVEACFTVFEDFLAYKSGVYVHTTGKDLGGHCVKLVGFG 269
Query: 413 TTDDGEDYWLLANQWNRSWGDDGYFMIRRGTNECGIEDEPV 291
T +G DY+ NQW SWGD+G F+I+RG +CGI D+ V
Sbjct: 270 TL-NGVDYYAANNQWTTSWGDNGTFLIKRG--DCGISDDVV 307
>sp|Q4R5M2|CATB_MACFA Cathepsin B OS=Macaca fascicularis GN=CTSB PE=2 SV=1
Length = 339
Score = 168 bits (424), Expect = 1e-040
Identities = 78/166 (46%), Positives = 106/166 (63%), Gaps = 2/166 (1%)
Frame = -1
Query: 767 ISAWQYFSYSGVVTEECDPYFDQTGCSHPGCEPAYNTPQCLRKC-VGRNQLWSESKHYSI 591
+S Y S+ G P S P C +TP+C + C G + + + KHY
Sbjct: 168 VSGGLYDSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGY 227
Query: 590 NTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGT 411
N+Y V ++ +DIMAEIYKNGPVE +F+VY DF YKSGVY+H+TG +GGHA++++GWG
Sbjct: 228 NSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWG- 286
Query: 410 TDDGEDYWLLANQWNRSWGDDGYFMIRRGTNECGIEDEPVGGLPST 273
++G YWL+AN WN WGD+G+F I RG + CGIE E V G+P T
Sbjct: 287 VENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRT 332
Score = 149 bits (376), Expect = 4e-035
Identities = 83/180 (46%), Positives = 107/180 (59%), Gaps = 24/180 (13%)
Frame = -1
Query: 1169 LQEEIVKKVNEHPNAGWKAAINDRFSNATVAEFKRLLGVKPTPKKLLLGVPV----VSHD 1002
L +E+V VN+ N W+A N F N V+ KRL G LG P V
Sbjct: 26 LSDELVNYVNKQ-NTTWQAGHN--FYNVDVSYLKRLCGT-------FLGGPKPPQRVMFT 75
Query: 1001 QSLKLPKSFDARTHWPQCTSIGKILDQGHCGSCWAFGAVESLSDRFCIQFGMNITLSVN- 825
+ LKLP+SFDAR WPQC +I +I DQG CGSCWAFGAVE++SDR CI ++++ V+
Sbjct: 76 EDLKLPESFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSA 135
Query: 824 -DLLACCGFRCGDGCDGGYPISAWQYFSYSGVVTEECDPYFDQTGCSHPGCEPAYNTPQC 648
DLL CCG CGDGC+GGYP AW +++ G+V+ +D SH GC P Y+ P C
Sbjct: 136 EDLLTCCGIMCGDGCNGGYPAGAWNFWTRKGLVS---GGLYD----SHVGCRP-YSIPPC 187
>sp|A1E295|CATB_PIG Cathepsin B OS=Sus scrofa GN=CTSB PE=1 SV=1
Length = 335
Score = 164 bits (415), Expect = 1e-039
Identities = 76/166 (45%), Positives = 103/166 (62%), Gaps = 2/166 (1%)
Frame = -1
Query: 767 ISAWQYFSYSGVVTEECDPYFDQTGCSHPGCEPAYNTPQCLRKC-VGRNQLWSESKHYSI 591
+S Y S+ G P S P C +TP+C + C G + E KH+
Sbjct: 168 VSGGLYDSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYTPSYKEDKHFGC 227
Query: 590 NTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGT 411
++Y + N ++IMAEIYKNGPVE +FTVY DF YKSGVY+H+TG +GGHA++++GWG
Sbjct: 228 SSYSISRNEKEIMAEIYKNGPVEGAFTVYSDFLQYKSGVYQHVTGDLMGGHAIRILGWG- 286
Query: 410 TDDGEDYWLLANQWNRSWGDDGYFMIRRGTNECGIEDEPVGGLPST 273
++G YWL+ N WN WGD+G+F I RG + CGIE E V G+P T
Sbjct: 287 VENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGIPCT 332
Score = 139 bits (349), Expect = 6e-032
Identities = 76/188 (40%), Positives = 108/188 (57%), Gaps = 24/188 (12%)
Frame = -1
Query: 1193 KQKLSSKILQEEIVKKVNEHPNAGWKAAINDRFSNATVAEFKRL----LGVKPTPKKLLL 1026
++ L + L +E+V +N+ N W A N F N ++ K+L LG P++
Sbjct: 18 RESLHFQPLSDELVNFINKQ-NTTWTAGHN--FYNVDLSYVKKLCGTFLGGPKLPQRAAF 74
Query: 1025 GVPVVSHDQSLKLPKSFDARTHWPQCTSIGKILDQGHCGSCWAFGAVESLSDRFCIQFG- 849
++ LPKSFDAR WP C +I +I DQG CGSCWAFGAVE++SDR CI+
Sbjct: 75 AADMI-------LPKSFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIRSNG 127
Query: 848 -MNITLSVNDLLACCGFRCGDGCDGGYPISAWQYFSYSGVVTEECDPYFDQTGCSHPGCE 672
+N+ +S D+L CCG CGDGC+GG+P AW +++ G+V+ +D SH GC
Sbjct: 128 RVNVEVSAEDMLTCCGDECGDGCNGGFPSGAWNFWTKKGLVS---GGLYD----SHVGCR 180
Query: 671 PAYNTPQC 648
P Y+ P C
Sbjct: 181 P-YSIPPC 187
>sp|P00787|CATB_RAT Cathepsin B OS=Rattus norvegicus GN=Ctsb PE=1 SV=2
Length = 339
Score = 164 bits (415), Expect = 1e-039
Identities = 78/167 (46%), Positives = 104/167 (62%), Gaps = 2/167 (1%)
Frame = -1
Query: 767 ISAWQYFSYSGVVTEECDPYFDQTGCSHPGCEPAYNTPQCLRKC-VGRNQLWSESKHYSI 591
+S Y S+ G + P S P C +TP+C + C G + + E KHY
Sbjct: 168 VSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGY 227
Query: 590 NTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGT 411
+Y V + ++IMAEIYKNGPVE +FTV+ DF YKSGVYKH G +GGHA++++GWG
Sbjct: 228 TSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWG- 286
Query: 410 TDDGEDYWLLANQWNRSWGDDGYFMIRRGTNECGIEDEPVGGLPSTK 270
++G YWL+AN WN WGD+G+F I RG N CGIE E V G+P T+
Sbjct: 287 IENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEIVAGIPRTQ 333
>sp|P07688|CATB_BOVIN Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5
Length = 335
Score = 162 bits (409), Expect = 6e-039
Identities = 75/166 (45%), Positives = 105/166 (63%), Gaps = 2/166 (1%)
Frame = -1
Query: 767 ISAWQYFSYSGVVTEECDPYFDQTGCSHPGCEPAYNTPQCLRKC-VGRNQLWSESKHYSI 591
+S Y S+ G P S P C +TP+C + C G + + E KH+
Sbjct: 168 VSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGC 227
Query: 590 NTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGT 411
++Y V +N ++IMAEIYKNGPVE +F+VY DF YKSGVY+H++G +GGHA++++GWG
Sbjct: 228 SSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWG- 286
Query: 410 TDDGEDYWLLANQWNRSWGDDGYFMIRRGTNECGIEDEPVGGLPST 273
++G YWL+ N WN WGD+G+F I RG + CGIE E V G+P T
Sbjct: 287 VENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMPCT 332
>sp|P43508|CPR4_CAEEL Cathepsin B-like cysteine proteinase 4 OS=Caenorhabditis
elegans GN=cpr-4 PE=2 SV=1
Length = 335
Score = 161 bits (406), Expect = 1e-038
Identities = 72/138 (52%), Positives = 93/138 (67%), Gaps = 4/138 (2%)
Frame = -1
Query: 683 PGC-EPAYNTPQCLRKCVGRNQ--LWSESKHYSINTYVVESNPQDIMAEIYKNGPVEVSF 513
P C + Y+TP C+ KC +N ++ KH+ Y V I AEI +GPVE +F
Sbjct: 197 PSCPDDGYDTPACVNKCTNKNYNVAYTADKHFGSTAYAVGKKVSQIQAEIIAHGPVEAAF 256
Query: 512 TVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGTTDDGEDYWLLANQWNRSWGDDGYFMI 333
TVYEDF YK+GVY H TG +GGHA++++GWG TD+G YWL+AN WN +WG++GYF I
Sbjct: 257 TVYEDFYQYKTGVYVHTTGQELGGHAIRILGWG-TDNGTPYWLVANSWNVNWGENGYFRI 315
Query: 332 RRGTNECGIEDEPVGGLP 279
RGTNECGIE VGG+P
Sbjct: 316 IRGTNECGIEHAVVGGVP 333
>sp|P43233|CATB_CHICK Cathepsin B OS=Gallus gallus GN=CTSB PE=2 SV=1
Length = 340
Score = 157 bits (396), Expect = 2e-037
Identities = 77/165 (46%), Positives = 100/165 (60%), Gaps = 3/165 (1%)
Frame = -1
Query: 767 ISAWQYFSYSGVVTEECDPYFDQTGCSHPGCE-PAYNTPQCLRKC-VGRNQLWSESKHYS 594
+S Y S+ G P S P C TP+C R C G + + E KHY
Sbjct: 168 VSGGLYDSHVGCRAYTIPPCEHHVNGSRPPCTGEGGETPRCSRHCEPGYSPSYKEDKHYG 227
Query: 593 INTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWG 414
I +Y V + ++IMAEIYKNGPVE +F VYEDF YKSGVY+H++G +GGHA++++GWG
Sbjct: 228 ITSYGVPRSEKEIMAEIYKNGPVEGAFIVYEDFLMYKSGVYQHVSGEQVGGHAIRILGWG 287
Query: 413 TTDDGEDYWLLANQWNRSWGDDGYFMIRRGTNECGIEDEPVGGLP 279
++G YWL AN WN WG G+F I RG + CGIE E V G+P
Sbjct: 288 -VENGTPYWLAANSWNTDWGITGFFKILRGEDHCGIESEIVAGVP 331
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 OS=Caenorhabditis
elegans GN=cpr-5 PE=1 SV=1
Length = 344
Score = 151 bits (380), Expect = 1e-035
Identities = 69/143 (48%), Positives = 89/143 (62%), Gaps = 5/143 (3%)
Frame = -1
Query: 695 GCSHPGC-EPAYNTPQCLRKCVGRNQL---WSESKHYSINTYVVESNPQDIMAEIYKNGP 528
G P C E TP+C+ C +N + + KH+ Y V + I EI NGP
Sbjct: 197 GVKWPACPEDTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEILTNGP 256
Query: 527 VEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGTTDDGEDYWLLANQWNRSWGDD 348
+EV+FTVYEDF Y +GVY H G+++GGHAVK++GWG D+G YWL+AN WN +WG+
Sbjct: 257 IEVAFTVYEDFYQYTTGVYVHTAGASLGGHAVKILGWG-VDNGTPYWLVANSWNVAWGEK 315
Query: 347 GYFMIRRGTNECGIEDEPVGGLP 279
GYF I RG NECGIE V G+P
Sbjct: 316 GYFRIIRGLNECGIEHSAVAGIP 338
>sp|Q06544|CYSP3_OSTOS Cathepsin B-like cysteine proteinase 3 (Fragment)
OS=Ostertagia ostertagi GN=CP-3 PE=3 SV=1
Length = 174
Score = 150 bits (377), Expect = 3e-035
Identities = 75/174 (43%), Positives = 100/174 (57%), Gaps = 15/174 (8%)
Frame = -1
Query: 761 AWQYFSYSGVVT------EECDPYFDQTGCSHPGCEPAY-------NTPQCLRKCV-GRN 624
AWQYF+ GVVT + C ++ C G EP Y TP+C + C G
Sbjct: 1 AWQYFALEGVVTGGNYRKQGCCRPYEFPPCGRHGKEPYYGECYDTAKTPKCQKTCQRGYL 60
Query: 623 QLWSESKHYSINTYVVESNPQDIMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIG 444
+ + E KH+ + Y + +N + I +I KNGPV F VYEDFAHYKSG+YKH G G
Sbjct: 61 KAYKEDKHFGKSAYRLPNNVKAIQRDIMKNGPVVAGFIVYEDFAHYKSGIYKHTAGRMTG 120
Query: 443 GHAVKLIGWGTTDDGEDYWLLANQWNRSWGDDGYFMIRRGTNECGIEDEPVGGL 282
GHAVK+IGWG + G YWL+AN W+ WG+ G++ + RG N C IE+ G+
Sbjct: 121 GHAVKIIGWG-KEKGTPYWLIANSWHDDWGEKGFYRMIRGINNCRIEEMVFAGI 173
>sp|P19092|CYSP1_HAECO Cathepsin B-like cysteine proteinase 1 OS=Haemonchus
contortus GN=AC-1 PE=2 SV=1
Length = 342
Score = 144 bits (363), Expect = 1e-033
Identities = 66/139 (47%), Positives = 89/139 (64%), Gaps = 2/139 (1%)
Frame = -1
Query: 677 CEPAYNTPQCLRKC-VGRNQLWSESKHYSINTYVVESNPQDIMAEIYKNGPVEVSFTVYE 501
C TP C RKC G +++ K Y + Y+V+ + + I +EI +NGPV SF VYE
Sbjct: 205 CRGTAPTPPCKRKCRPGVRKMYRIDKRYGKDAYIVKQSVKAIQSEILRNGPVVASFAVYE 264
Query: 500 DFAHYKSGVYKHITGSNIGGHAVKLIGWGTTDDGEDYWLLANQWNRSWGDDGYFMIRRGT 321
DF HYKSG+YKH G G HAVK+IGWG ++ D+WL+AN W+ WG+ GYF I RGT
Sbjct: 265 DFRHYKSGIYKHTAGELRGYHAVKMIGWG-NENNTDFWLIANSWHNDWGEKGYFRIIRGT 323
Query: 320 NECGIEDEPVGGLPSTKNV 264
N+CGIE G+ T+++
Sbjct: 324 NDCGIEGTIAAGIVDTESL 342
>sp|P25793|CYSP2_HAECO Cathepsin B-like cysteine proteinase 2 OS=Haemonchus
contortus GN=AC-2 PE=2 SV=1
Length = 342
Score = 144 bits (362), Expect = 2e-033
Identities = 66/139 (47%), Positives = 89/139 (64%), Gaps = 2/139 (1%)
Frame = -1
Query: 677 CEPAYNTPQCLRKC-VGRNQLWSESKHYSINTYVVESNPQDIMAEIYKNGPVEVSFTVYE 501
C TP C RKC G +++ K Y + Y+V+ + + I +EI KNGPV SF VYE
Sbjct: 205 CRGTAPTPPCKRKCRPGVRKMYRIDKRYGKDAYIVKQSVKAIQSEILKNGPVVASFAVYE 264
Query: 500 DFAHYKSGVYKHITGSNIGGHAVKLIGWGTTDDGEDYWLLANQWNRSWGDDGYFMIRRGT 321
DF HYKSG+YKH G G HAVK+IGWG ++ D+WL+AN W+ WG+ GYF I RG+
Sbjct: 265 DFRHYKSGIYKHTAGELRGYHAVKMIGWG-NENNTDFWLIANSWHNDWGEKGYFRIVRGS 323
Query: 320 NECGIEDEPVGGLPSTKNV 264
N+CGIE G+ T+++
Sbjct: 324 NDCGIEGTIAAGIVDTESL 342
>sp|P92133|CATB3_GIALA Cathepsin B-like CP3 OS=Giardia lamblia GN=CP3 PE=2 SV=2
Length = 299
Score = 121 bits (303), Expect = 1e-026
Identities = 50/91 (54%), Positives = 66/91 (72%)
Frame = -1
Query: 557 IMAEIYKNGPVEVSFTVYEDFAHYKSGVYKHITGSNIGGHAVKLIGWGTTDDGEDYWLLA 378
IM + GP++ +FTVY DF +Y+SGVY+H G GGHAV ++G+GT DDG DYW++
Sbjct: 205 IMKALATGGPLQTAFTVYSDFMYYESGVYQHTYGRVEGGHAVDMVGYGTDDDGVDYWIIK 264
Query: 377 NQWNRSWGDDGYFMIRRGTNECGIEDEPVGG 285
N W WG+DGYF I R TNECGIE++ +GG
Sbjct: 265 NSWGPDWGEDGYFRIIRMTNECGIEEQVIGG 295
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,759,707,213
Number of Sequences: 518415
Number of Extensions: 54759707213
Number of Successful Extensions: 366332288
Number of sequences better than 0.0: 0
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