BLASTX 7.6.2
Query= UN13173 /QuerySize=1008
(1007 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P49755|TMEDA_HUMAN Transmembrane emp24 domain-containing prot... 111 1e-023
sp|Q5E971|TMEDA_BOVIN Transmembrane emp24 domain-containing prot... 109 4e-023
sp|Q28735|TMEDA_RABIT Transmembrane emp24 domain-containing prot... 108 9e-023
sp|Q5RE32|TMEDA_PONAB Transmembrane emp24 domain-containing prot... 107 1e-022
sp|Q63584|TMEDA_RAT Transmembrane emp24 domain-containing protei... 107 2e-022
sp|Q9D1D4|TMEDA_MOUSE Transmembrane emp24 domain-containing prot... 106 3e-022
sp|Q90515|TMEDA_TAKRU Transmembrane emp24 domain-containing prot... 106 3e-022
sp|O35587|TMEDA_MESAU Transmembrane protein Tmp21 OS=Mesocricetu... 106 5e-022
sp|P53198|ERP6_YEAST Protein ERP6 OS=Saccharomyces cerevisiae GN... 79 6e-014
>sp|P49755|TMEDA_HUMAN Transmembrane emp24 domain-containing protein 10 OS=Homo
sapiens GN=TMED10 PE=1 SV=2
Length = 219
Score = 111 bits (275), Expect = 1e-023
Identities = 58/204 (28%), Positives = 114/204 (55%), Gaps = 7/204 (3%)
Frame = +3
Query: 108 MILVISSRVAHSLHFDLHSGRTKCIAEDIKSNSMTVGKYSVDNPHEGHDLPQSHKISVKV 287
++ ++ R+ ++ F L KC+ E+I + + G Y + + G +SH +K+
Sbjct: 20 LLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSH---LKI 76
Query: 288 TSSNGNAYHHADQVASGQFAFSAVEAGDYMACFSA--VDHKPEVTLSIDFEWRTGVQSKS 461
T S G+ + + G+FAF+ + + CF + P+ + +D + GV++K+
Sbjct: 77 TDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDM--KHGVEAKN 134
Query: 462 WATVAKKSQVETMEFDVKSLLDTVNSIHEEMFYLREREEQMQDLNRSTNTKMAWLSLLSL 641
+ +AK +++ +E +++ L D SI + Y+++REE+M+D N STNT++ + S+ S+
Sbjct: 135 YEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSM 194
Query: 642 FVCIGVAAMQYVHLKTFFEKKKVI 713
F IG+A Q +L+ FF+ KK+I
Sbjct: 195 FCLIGLATWQVFYLRRFFKAKKLI 218
>sp|Q5E971|TMEDA_BOVIN Transmembrane emp24 domain-containing protein 10 OS=Bos
taurus GN=TMED10 PE=2 SV=1
Length = 219
Score = 109 bits (271), Expect = 4e-023
Identities = 61/210 (29%), Positives = 119/210 (56%), Gaps = 9/210 (4%)
Frame = +3
Query: 90 WTVVAFMILVISSRVAHSLHFDLHSGRTKCIAEDIKSNSMTVGKYSVDNPHEGHDLPQSH 269
+ ++ ++L SS +A S H ++S KC+ E+I + + G Y + + G ++H
Sbjct: 16 FALLLLLLLGPSSVLAISFHLPVNS--RKCLREEIHKDLLVTGAYEITDQSGGAGGLRTH 73
Query: 270 KISVKVTSSNGNAYHHADQVASGQFAFSAVEAGDYMACFSA--VDHKPEVTLSIDFEWRT 443
+K+T S G+ + + G+FAF+ + + CF + P+ + +D +
Sbjct: 74 ---LKITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDM--KH 128
Query: 444 GVQSKSWATVAKKSQVETMEFDVKSLLDTVNSIHEEMFYLREREEQMQDLNRSTNTKMAW 623
GV++K++ +AK +++ +E +++ L D SI + Y+++REE+M+D N STNT++ +
Sbjct: 129 GVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLY 188
Query: 624 LSLLSLFVCIGVAAMQYVHLKTFFEKKKVI 713
S+ S+F IG+A Q +L+ FF+ KK+I
Sbjct: 189 FSIFSMFCLIGLATWQVFYLRRFFKAKKLI 218
>sp|Q28735|TMEDA_RABIT Transmembrane emp24 domain-containing protein 10
OS=Oryctolagus cuniculus GN=TMED10 PE=1 SV=1
Length = 219
Score = 108 bits (268), Expect = 9e-023
Identities = 60/199 (30%), Positives = 114/199 (57%), Gaps = 9/199 (4%)
Frame = +3
Query: 123 SSRVAHSLHFDLHSGRTKCIAEDIKSNSMTVGKYSVDNPHEGHDLPQSHKISVKVTSSNG 302
SS +A S H ++S KC+ E+I + + G Y + + G ++H +K+T S G
Sbjct: 27 SSVLAISFHLPVNS--RKCLREEIHKDLLVTGAYEITDQSGGAGGLRTH---LKITDSAG 81
Query: 303 NAYHHADQVASGQFAFSAVEAGDYMACFSA--VDHKPEVTLSIDFEWRTGVQSKSWATVA 476
+ + + + G+FAF+ + + CF + P+ + +D + GV++K++ +A
Sbjct: 82 HILYSKEDASKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDM--KHGVEAKNYEEIA 139
Query: 477 KKSQVETMEFDVKSLLDTVNSIHEEMFYLREREEQMQDLNRSTNTKMAWLSLLSLFVCIG 656
K +++ +E +++ L D SI + Y+++REE+M+D N STNT++ + S+ S+F IG
Sbjct: 140 KVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIG 199
Query: 657 VAAMQYVHLKTFFEKKKVI 713
+A Q +L+ FF+ KK+I
Sbjct: 200 LATWQVFYLRRFFKAKKLI 218
>sp|Q5RE32|TMEDA_PONAB Transmembrane emp24 domain-containing protein 10 OS=Pongo
abelii GN=TMED10 PE=2 SV=1
Length = 219
Score = 107 bits (267), Expect = 1e-022
Identities = 57/204 (27%), Positives = 112/204 (54%), Gaps = 7/204 (3%)
Frame = +3
Query: 108 MILVISSRVAHSLHFDLHSGRTKCIAEDIKSNSMTVGKYSVDNPHEGHDLPQSHKISVKV 287
++ ++ + ++ F L KC+ E+I + + G Y + + G +SH +K+
Sbjct: 20 LLFLLGPSLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSH---LKI 76
Query: 288 TSSNGNAYHHADQVASGQFAFSAVEAGDYMACFSA--VDHKPEVTLSIDFEWRTGVQSKS 461
T S G+ + + G+FAF+ + + CF + P+ + +D + GV++K+
Sbjct: 77 TDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDM--KHGVEAKN 134
Query: 462 WATVAKKSQVETMEFDVKSLLDTVNSIHEEMFYLREREEQMQDLNRSTNTKMAWLSLLSL 641
+ +AK +++ +E +++ L D SI + Y+ +REE+M+D N STNT++ + S+ S+
Sbjct: 135 YEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMEKREEEMRDTNESTNTRVLYFSIFSM 194
Query: 642 FVCIGVAAMQYVHLKTFFEKKKVI 713
F IG+A Q +L+ FF+ KK+I
Sbjct: 195 FCLIGLATWQVFYLRRFFKAKKLI 218
>sp|Q63584|TMEDA_RAT Transmembrane emp24 domain-containing protein 10 OS=Rattus
norvegicus GN=Tmed10 PE=1 SV=2
Length = 219
Score = 107 bits (265), Expect = 2e-022
Identities = 61/211 (28%), Positives = 116/211 (54%), Gaps = 8/211 (3%)
Frame = +3
Query: 87 LWTVVAFMILVISSRVAHSLHFDLHSGRTKCIAEDIKSNSMTVGKYSVDNPHEGHDLPQS 266
L + + F+ L+ S V + F L KC+ E+I + + G Y + + G ++
Sbjct: 14 LLSALLFLFLLGPSSVL-GISFHLPVNSRKCLREEIHKDLLVTGAYEITDQSGGAGGLRT 72
Query: 267 HKISVKVTSSNGNAYHHADQVASGQFAFSAVEAGDYMACFSA--VDHKPEVTLSIDFEWR 440
H +K+T S G+ + + G+FAF+ + + CF + P+ + +D +
Sbjct: 73 H---LKITDSAGHILYAKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDM--K 127
Query: 441 TGVQSKSWATVAKKSQVETMEFDVKSLLDTVNSIHEEMFYLREREEQMQDLNRSTNTKMA 620
GV++K++ +AK +++ +E +++ L D SI + Y+++REE+M+D N STNT++
Sbjct: 128 HGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVL 187
Query: 621 WLSLLSLFVCIGVAAMQYVHLKTFFEKKKVI 713
+ S+ S+F IG+A Q +L+ FF+ KK+I
Sbjct: 188 YFSIFSMFCLIGLATWQVFYLRRFFKAKKLI 218
>sp|Q9D1D4|TMEDA_MOUSE Transmembrane emp24 domain-containing protein 10 OS=Mus
musculus GN=Tmed10 PE=2 SV=1
Length = 219
Score = 106 bits (264), Expect = 3e-022
Identities = 60/205 (29%), Positives = 114/205 (55%), Gaps = 8/205 (3%)
Frame = +3
Query: 105 FMILVISSRVAHSLHFDLHSGRTKCIAEDIKSNSMTVGKYSVDNPHEGHDLPQSHKISVK 284
F++L+ S V + F L KC+ E+I + + G Y + + G ++H +K
Sbjct: 20 FLLLLGPSSVL-GISFHLPVNSRKCLREEIHKDLLVTGAYEITDQSGGAGGLRTH---LK 75
Query: 285 VTSSNGNAYHHADQVASGQFAFSAVEAGDYMACFSA--VDHKPEVTLSIDFEWRTGVQSK 458
+T S G+ + + G+FAF+ + + CF + P+ + +D + GV++K
Sbjct: 76 ITDSAGHILYAKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDM--KHGVEAK 133
Query: 459 SWATVAKKSQVETMEFDVKSLLDTVNSIHEEMFYLREREEQMQDLNRSTNTKMAWLSLLS 638
++ +AK +++ +E +++ L D SI + Y+++REE+M+D N STNT++ + S+ S
Sbjct: 134 NYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFS 193
Query: 639 LFVCIGVAAMQYVHLKTFFEKKKVI 713
+F IG+A Q +L+ FF+ KK+I
Sbjct: 194 MFCLIGLATWQVFYLRRFFKAKKLI 218
>sp|Q90515|TMEDA_TAKRU Transmembrane emp24 domain-containing protein 10
OS=Takifugu rubripes GN=tmed10 PE=3 SV=1
Length = 213
Score = 106 bits (263), Expect = 3e-022
Identities = 61/213 (28%), Positives = 116/213 (54%), Gaps = 11/213 (5%)
Frame = +3
Query: 93 TVVAFMILVISSRVAHSLHFDLHSGRTKCIAEDIKSNSMTVGKYSVDNP----HEGHDLP 260
T + F+ ++I S A S+ F L KC+ E+I + + G+Y + H +
Sbjct: 5 TALLFLPVLIES--AFSISFFLPVNTRKCLREEIHKDVLVTGEYEISEQVVTVHTSSTVV 62
Query: 261 QSHKISVKVTSSNGNAYHHADQVASGQFAFSAVEAGDYMACFSA--VDHKPEVTLSIDFE 434
I K+T S+ + + + G+FAF+ + + CF + P+ +++D
Sbjct: 63 GDGSI-FKITDSSSHTLYSKEDATKGKFAFTTEDYDMFEVCFESKCTGRVPDQLVNLDM- 120
Query: 435 WRTGVQSKSWATVAKKSQVETMEFDVKSLLDTVNSIHEEMFYLREREEQMQDLNRSTNTK 614
+ GV++K++ +AK +++ +E +++ L D SI + Y+++REE+M+D N STNT+
Sbjct: 121 -KHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTR 179
Query: 615 MAWLSLLSLFVCIGVAAMQYVHLKTFFEKKKVI 713
+ + S+ S+F IG+A Q +L+ FF+ KK+I
Sbjct: 180 VLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLI 212
>sp|O35587|TMEDA_MESAU Transmembrane protein Tmp21 OS=Mesocricetus auratus
GN=TMED10 PE=2 SV=1
Length = 219
Score = 106 bits (262), Expect = 5e-022
Identities = 60/204 (29%), Positives = 115/204 (56%), Gaps = 9/204 (4%)
Frame = +3
Query: 108 MILVISSRVAHSLHFDLHSGRTKCIAEDIKSNSMTVGKYSVDNPHEGHDLPQSHKISVKV 287
++L SS +A S H ++S KC+ E+I + + G Y + + G ++H +K+
Sbjct: 22 LLLGPSSVLAISFHLPVNS--RKCLREEIHKDLLVTGAYEITDQSGGAGGLRTH---LKI 76
Query: 288 TSSNGNAYHHADQVASGQFAFSAVEAGDYMACFSA--VDHKPEVTLSIDFEWRTGVQSKS 461
T S G+ + + G+FAF+ + + CF + P+ + +D + GV++K+
Sbjct: 77 TDSAGHILYAKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDM--KHGVEAKN 134
Query: 462 WATVAKKSQVETMEFDVKSLLDTVNSIHEEMFYLREREEQMQDLNRSTNTKMAWLSLLSL 641
+ +AK +++ +E +++ L D SI + Y+++REE+M+D N STNT++ + S+ S+
Sbjct: 135 YEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSM 194
Query: 642 FVCIGVAAMQYVHLKTFFEKKKVI 713
IG+A Q +L+ FF+ KK+I
Sbjct: 195 LCLIGLATWQVFYLRRFFKAKKLI 218
>sp|P53198|ERP6_YEAST Protein ERP6 OS=Saccharomyces cerevisiae GN=ERP6 PE=1
SV=1
Length = 216
Score = 79 bits (192), Expect = 6e-014
Identities = 55/214 (25%), Positives = 104/214 (48%), Gaps = 15/214 (7%)
Frame = +3
Query: 105 FMILVISSRVAHSLHFDLHSGRTKCIAEDIKSNSMTVGKYSV---DNPHEGHDLPQSHK- 272
F+ V+ + +F + G KC +++ +++ G Y++ D+ + LP +
Sbjct: 7 FLAFVLLPFRVSAFYFYGYGGDRKCFLKELSKDTLLKGSYNLEVYDDKLADYALPSYNDY 66
Query: 273 ---ISVKVTSSNGNAYHHADQVASGQFAFSAVEAGDYMACF-SAVDH---KPEVTLSIDF 431
I V+ N + H SG F+F A+E+G+Y C S V++ K + L I+F
Sbjct: 67 GIVIDVEEVFDNNHRVVHQQGSPSGDFSFLALESGEYKICLQSRVNNWVGKTKTKLEIEF 126
Query: 432 EWRTGVQSKSWATVAKKSQVETMEFDVKSLLDTVNSIHEEMFYLREREEQMQDLNRSTNT 611
E V ++ + +K +E++ V L + I E +REREE +D++ S N+
Sbjct: 127 E----VGFEAMLDMQRKETLESLHGKVSILNSKIVDIRREQQLMREREESFRDISESVNS 182
Query: 612 KMAWLSLLSLFVCIGVAAMQYVHLKTFFEKKKVI 713
+ W ++ + + I + Q L++FF K+KV+
Sbjct: 183 RAMWWTVTQVTLLIIICVWQMKSLRSFFVKQKVL 216
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,759,707,213
Number of Sequences: 518415
Number of Extensions: 54759707213
Number of Successful Extensions: 366332288
Number of sequences better than 0.0: 0
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