BLASTX 7.6.2
Query= UN13202 /QuerySize=2502
(2501 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8VZ96|DER21_ARATH Derlin-2.1 OS=Arabidopsis thaliana GN=DER2... 486 3e-136
sp|Q9ZS88|DER22_ARATH Derlin-2.2 OS=Arabidopsis thaliana GN=DER2... 470 4e-131
sp|Q851X7|DERL2_ORYSJ Derlin-2 OS=Oryza sativa subsp. japonica G... 411 2e-113
sp|Q4G2J3|DER22_MAIZE Derlin-2.2 OS=Zea mays GN=DER2.2 PE=2 SV=1 409 6e-113
sp|Q4G2J4|DER21_MAIZE Derlin-2.1 OS=Zea mays GN=DER2.1 PE=2 SV=2 407 3e-112
sp|Q54C25|GPN1_DICDI GPN-loop GTPase 1 homolog OS=Dictyostelium ... 386 5e-106
sp|Q9HCN4|GPN1_HUMAN GPN-loop GTPase 1 OS=Homo sapiens GN=GPN1 P... 365 1e-099
sp|A4FUD1|GPN1_BOVIN GPN-loop GTPase 1 OS=Bos taurus GN=GPN1 PE=... 360 3e-098
sp|Q8VCE2|GPN1_MOUSE GPN-loop GTPase 1 OS=Mus musculus GN=Gpn1 P... 358 1e-097
sp|P47122|NPA3_YEAST GTPase NPA3 OS=Saccharomyces cerevisiae GN=... 344 3e-093
sp|P46577|GPN1_CAEEL GPN-loop GTPase 1 homolog OS=Caenorhabditis... 304 2e-081
sp|O42906|NPA3_SCHPO GTPase npa3 OS=Schizosaccharomyces pombe GN... 297 3e-079
sp|Q54NN1|DERL2_DICDI Probable derlin-2 homolog OS=Dictyostelium... 232 1e-059
sp|Q9GZP9|DERL2_HUMAN Derlin-2 OS=Homo sapiens GN=DERL2 PE=1 SV=1 126 1e-027
sp|Q8BNI4|DERL2_MOUSE Derlin-2 OS=Mus musculus GN=Derl2 PE=2 SV=2 126 1e-027
sp|Q5RC74|DERL2_PONAB Derlin-2 OS=Pongo abelii GN=DERL2 PE=2 SV=1 126 1e-027
sp|Q0P5E4|DERL3_BOVIN Derlin-3 OS=Bos taurus GN=DERL3 PE=2 SV=1 126 1e-027
sp|Q96Q80|DERL3_HUMAN Derlin-3 OS=Homo sapiens GN=DERL3 PE=1 SV=2 126 1e-027
sp|Q9D8K3|DERL3_MOUSE Derlin-3 OS=Mus musculus GN=Derl3 PE=2 SV=1 119 2e-025
sp|Q21997|DERL2_CAEEL Derlin-2 OS=Caenorhabditis elegans GN=der-... 112 2e-023
>sp|Q8VZ96|DER21_ARATH Derlin-2.1 OS=Arabidopsis thaliana GN=DER2.1 PE=2 SV=2
Length = 244
Score = 486 bits (1251), Expect = 3e-136
Identities = 235/244 (96%), Positives = 238/244 (97%)
Frame = -1
Query: 2336 MAQAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNF 2157
MAQAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNF
Sbjct: 1 MAQAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNF 60
Query: 2156 LYFRNMDLDFLFHMFFLARYCKLLEENSFRGKTADFLYMLLFGATALTGIVLVGGMIPYL 1977
LYFR MDLDFLFHMFFLARYCKLLEENSFRGKT DFLYMLLFGAT LTGIVL+GGMIPYL
Sbjct: 61 LYFRKMDLDFLFHMFFLARYCKLLEENSFRGKTTDFLYMLLFGATVLTGIVLIGGMIPYL 120
Query: 1976 SVSFSKIIFLSNSLTFMMVYVWSKQNPYIHMSFLGLFTFTAAYLPWVLLGFSVLVGASPW 1797
SVSFSKIIFLSNSLTFMMVYVWSKQNPYIHMSFLGLFTFTAAYLPWVLLGFS+LVGAS W
Sbjct: 121 SVSFSKIIFLSNSLTFMMVYVWSKQNPYIHMSFLGLFTFTAAYLPWVLLGFSILVGASAW 180
Query: 1796 GDLLGMIAGHAYYFLAFVYPRMTDRRPLKTPSFLKALFADEPVVVARPEDVRFAHTPFDE 1617
GD LGMIAGHAYYFLAFVYPRMTDRRPLKTPSFLKALFADEPVV+ARPEDVRFAH PFDE
Sbjct: 181 GDFLGMIAGHAYYFLAFVYPRMTDRRPLKTPSFLKALFADEPVVIARPEDVRFAHAPFDE 240
Query: 1616 IHQD 1605
IHQD
Sbjct: 241 IHQD 244
>sp|Q9ZS88|DER22_ARATH Derlin-2.2 OS=Arabidopsis thaliana GN=DER2.2 PE=2 SV=1
Length = 244
Score = 470 bits (1207), Expect = 4e-131
Identities = 227/244 (93%), Positives = 236/244 (96%)
Frame = -1
Query: 2336 MAQAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNF 2157
MAQAVEEWYKQMPIITRSYLTAAV+TTVGCSL+IISPYNLYLNPTLVVKQYQ+WRLVTNF
Sbjct: 1 MAQAVEEWYKQMPIITRSYLTAAVITTVGCSLDIISPYNLYLNPTLVVKQYQYWRLVTNF 60
Query: 2156 LYFRNMDLDFLFHMFFLARYCKLLEENSFRGKTADFLYMLLFGATALTGIVLVGGMIPYL 1977
LYFR MDLDF+FHMFFLARYCKLLEENSFRGKTADFLYMLLFGA+ LTGIVL+GGMIPYL
Sbjct: 61 LYFRKMDLDFMFHMFFLARYCKLLEENSFRGKTADFLYMLLFGASVLTGIVLIGGMIPYL 120
Query: 1976 SVSFSKIIFLSNSLTFMMVYVWSKQNPYIHMSFLGLFTFTAAYLPWVLLGFSVLVGASPW 1797
S SF+KIIFLSNSLTFMMVYVWSKQNPYIHMSFLGLFTFTAAYLPWVLLGFS+LVGAS W
Sbjct: 121 SASFAKIIFLSNSLTFMMVYVWSKQNPYIHMSFLGLFTFTAAYLPWVLLGFSILVGASAW 180
Query: 1796 GDLLGMIAGHAYYFLAFVYPRMTDRRPLKTPSFLKALFADEPVVVARPEDVRFAHTPFDE 1617
DLLGMIAGHAYYFLA VYPRMT+RRPLKTPSFLKALFADEPVVVARPEDVRFA PFDE
Sbjct: 181 VDLLGMIAGHAYYFLAEVYPRMTNRRPLKTPSFLKALFADEPVVVARPEDVRFAAAPFDE 240
Query: 1616 IHQD 1605
IHQD
Sbjct: 241 IHQD 244
>sp|Q851X7|DERL2_ORYSJ Derlin-2 OS=Oryza sativa subsp. japonica GN=DER2 PE=2
SV=1
Length = 249
Score = 411 bits (1054), Expect = 2e-113
Identities = 196/228 (85%), Positives = 213/228 (93%)
Frame = -1
Query: 2336 MAQAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNF 2157
MAQAVEEWY+QMPIITRSYLTAAVVTTVGC+LEIISPY+LYLNP LVV+ Y+ WRLVTNF
Sbjct: 1 MAQAVEEWYRQMPIITRSYLTAAVVTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNF 60
Query: 2156 LYFRNMDLDFLFHMFFLARYCKLLEENSFRGKTADFLYMLLFGATALTGIVLVGGMIPYL 1977
LYFR MDLDFLFHMFFLARYCKLLEENSFRG+TADF YMLLFGAT LTGIVL+GGMIPY+
Sbjct: 61 LYFRKMDLDFLFHMFFLARYCKLLEENSFRGRTADFFYMLLFGATVLTGIVLIGGMIPYI 120
Query: 1976 SVSFSKIIFLSNSLTFMMVYVWSKQNPYIHMSFLGLFTFTAAYLPWVLLGFSVLVGASPW 1797
S +F++I+FLSNSLTFMMVYVWSK NP+IHMSFLGLFTFTAAYLPWVLLGFS+LVG+S W
Sbjct: 121 SETFARILFLSNSLTFMMVYVWSKHNPFIHMSFLGLFTFTAAYLPWVLLGFSILVGSSTW 180
Query: 1796 GDLLGMIAGHAYYFLAFVYPRMTDRRPLKTPSFLKALFADEPVVVARP 1653
DLLGMIAGH YYFL VYPRMT RRPLKTPSF+KALFAD+ VVVARP
Sbjct: 181 VDLLGMIAGHVYYFLEDVYPRMTGRRPLKTPSFIKALFADDNVVVARP 228
>sp|Q4G2J3|DER22_MAIZE Derlin-2.2 OS=Zea mays GN=DER2.2 PE=2 SV=1
Length = 249
Score = 409 bits (1050), Expect = 6e-113
Identities = 195/228 (85%), Positives = 213/228 (93%)
Frame = -1
Query: 2336 MAQAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNF 2157
MAQAVEEWY+QMPIITRSYLTAAVVTTVGC+LEIISPY+LYLNP LVV+ Y+ WRLVTNF
Sbjct: 1 MAQAVEEWYRQMPIITRSYLTAAVVTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNF 60
Query: 2156 LYFRNMDLDFLFHMFFLARYCKLLEENSFRGKTADFLYMLLFGATALTGIVLVGGMIPYL 1977
LYFR MDLDFLFHMFFLARYCKLLEENSFRG+TADF YMLLFGAT LTGIVL+GGMIPY+
Sbjct: 61 LYFRKMDLDFLFHMFFLARYCKLLEENSFRGRTADFFYMLLFGATVLTGIVLIGGMIPYI 120
Query: 1976 SVSFSKIIFLSNSLTFMMVYVWSKQNPYIHMSFLGLFTFTAAYLPWVLLGFSVLVGASPW 1797
S +F++I+FLSNSLTFMMVYVWSK NP+IHMSFLGLFTFTAAYLPWVLLGFS+LVG+S W
Sbjct: 121 SETFARILFLSNSLTFMMVYVWSKHNPFIHMSFLGLFTFTAAYLPWVLLGFSILVGSSTW 180
Query: 1796 GDLLGMIAGHAYYFLAFVYPRMTDRRPLKTPSFLKALFADEPVVVARP 1653
DLLGMIAGH YYFL VYPRMT RRPLKTPSF+KALFAD+ VVVA+P
Sbjct: 181 VDLLGMIAGHVYYFLEDVYPRMTGRRPLKTPSFIKALFADDNVVVAQP 228
>sp|Q4G2J4|DER21_MAIZE Derlin-2.1 OS=Zea mays GN=DER2.1 PE=2 SV=2
Length = 249
Score = 407 bits (1044), Expect = 3e-112
Identities = 194/228 (85%), Positives = 212/228 (92%)
Frame = -1
Query: 2336 MAQAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNF 2157
MAQAVEEWY+QMPIITRSYLTAAVVTTVGC+LEIISPY+LYLNP LVV+ Y+ WRLVTNF
Sbjct: 1 MAQAVEEWYRQMPIITRSYLTAAVVTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNF 60
Query: 2156 LYFRNMDLDFLFHMFFLARYCKLLEENSFRGKTADFLYMLLFGATALTGIVLVGGMIPYL 1977
LYFR MDLDFLFHMFFLARYCKLLEENSFRG+TADF YMLLFGAT LT IVL+GGMIPY+
Sbjct: 61 LYFRKMDLDFLFHMFFLARYCKLLEENSFRGRTADFFYMLLFGATVLTSIVLIGGMIPYI 120
Query: 1976 SVSFSKIIFLSNSLTFMMVYVWSKQNPYIHMSFLGLFTFTAAYLPWVLLGFSVLVGASPW 1797
S +F++I+FLSNSLTFMMVYVWSK NP+IHMSFLGLFTFTAAYLPWVLLGFS+LVG+S W
Sbjct: 121 SETFARILFLSNSLTFMMVYVWSKHNPFIHMSFLGLFTFTAAYLPWVLLGFSILVGSSTW 180
Query: 1796 GDLLGMIAGHAYYFLAFVYPRMTDRRPLKTPSFLKALFADEPVVVARP 1653
DLLGMIAGH YYFL VYPRMT RRPLKTPSF+KALFAD+ VVVA+P
Sbjct: 181 VDLLGMIAGHVYYFLEDVYPRMTGRRPLKTPSFIKALFADDNVVVAQP 228
>sp|Q54C25|GPN1_DICDI GPN-loop GTPase 1 homolog OS=Dictyostelium discoideum
GN=xab1 PE=3 SV=1
Length = 396
Score = 386 bits (990), Expect = 5e-106
Identities = 190/355 (53%), Positives = 264/355 (74%), Gaps = 7/355 (1%)
Frame = +1
Query: 166 DKLRVSAGSSSSN-FKKKPVIIIVVGMAGSGKTSFLHRLVCHTFDANKRGYVLNLDPAVM 342
DK V+ +++ N +K+P+ IIV+GMAGSGKT+ L R+ H ++ GY++NLDPAV
Sbjct: 16 DKDNVNNNNNNENKEEKQPINIIVLGMAGSGKTTLLQRIRAHLYENKIPGYIINLDPAVS 75
Query: 343 SLPFGANIDIRDTVKYKEVMKQYNLGPNGGIMTSLNLFATKFDEVVSVIEKRADQLDYVL 522
LP+ NIDIRDTV YKEVMKQ+NLGPNGGI+TSLNLF+TKFD+V+ ++EKR+ LDY++
Sbjct: 76 KLPYTPNIDIRDTVNYKEVMKQFNLGPNGGIVTSLNLFSTKFDKVLEIVEKRSSSLDYII 135
Query: 523 VDTPGQIEIFTWSASGAIITEAFASTFPTVVTYVVDTPRSTSPITFMSNMLYACSILYKT 702
+DTPGQIE+FTWSASG IITE AS+FPTV+ YVVDTPR+ P TFMSNMLYACSI+YK+
Sbjct: 136 LDTPGQIEVFTWSASGTIITELMASSFPTVLVYVVDTPRTVDPTTFMSNMLYACSIMYKS 195
Query: 703 RLPLVLAFNKTDVADHKFALEWMEDFEVFQAAIQSDNSYTSTLANSLSLSLYEFYRNIRS 882
+LP+V+AFNK D+ +H+FA EWM DF+ FQ A+ +D +Y L SLSL L EFY ++S
Sbjct: 196 KLPMVVAFNKIDITNHRFAEEWMSDFDSFQDALTNDPTYMGNLTRSLSLVLEEFYSTLQS 255
Query: 883 VGVSAITGAGMDDFFKAIEASADEYMQTYKADLDKRKAEKEQLEEERREKEMEKLRKDME 1062
VGVSA+ G+G+D+FF+ I +A +Y + YKADL+K K +K E+ K EKL++D+E
Sbjct: 256 VGVSAVDGSGIDEFFEKIGLAAQDYHKYYKADLEKIKKQKSDKEQAEANKNWEKLKRDLE 315
Query: 1063 SSQGGTVVLN-TGLKDRDAAEKMM-VEEEDDDDFKIEEDSDDAID----EDEEDE 1209
S+G V + K R+ EK + ++++DD++ + D +D+ + EDE++E
Sbjct: 316 ESKGAKVEYDFKKEKKRENQEKTKNIYDDEEDDYRDDRDMEDSGEYESYEDEQEE 370
>sp|Q9HCN4|GPN1_HUMAN GPN-loop GTPase 1 OS=Homo sapiens GN=GPN1 PE=1 SV=1
Length = 374
Score = 365 bits (936), Expect = 1e-099
Identities = 182/354 (51%), Positives = 248/354 (70%), Gaps = 17/354 (4%)
Frame = +1
Query: 181 SAGSSSSNFKKKPVIIIVVGMAGSGKTSFLHRLVCHTFDANKRGYVLNLDPAVMSLPFGA 360
+A +S + PV ++V+GMAGSGKT+F+ RL H YV+NLDPAV +PF A
Sbjct: 7 AAELQASGGPRHPVCLLVLGMAGSGKTTFVQRLTGHLHAQGTPPYVINLDPAVHEVPFPA 66
Query: 361 NIDIRDTVKYKEVMKQYNLGPNGGIMTSLNLFATKFDEVVSVIEKRADQLDYVLVDTPGQ 540
NIDIRDTVKYKEVMKQY LGPNGGI+TSLNLFAT+FD+V+ IEK + YVL+DTPGQ
Sbjct: 67 NIDIRDTVKYKEVMKQYGLGPNGGIVTSLNLFATRFDQVMKFIEKAQNMSKYVLIDTPGQ 126
Query: 541 IEIFTWSASGAIITEAFASTFPTVVTYVVDTPRSTSPITFMSNMLYACSILYKTRLPLVL 720
IE+FTWSASG IITEA AS+FPTVV YV+DT RST+P+TFMSNMLYACSILYKT+LP ++
Sbjct: 127 IEVFTWSASGTIITEALASSFPTVVIYVMDTSRSTNPVTFMSNMLYACSILYKTKLPFIV 186
Query: 721 AFNKTDVADHKFALEWMEDFEVFQAAIQSDNSYTSTLANSLSLSLYEFYRNIRSVGVSAI 900
NKTD+ DH FA+EWM+DFE FQ A+ + +Y S L S+SL L EFY ++R VGVSA+
Sbjct: 187 VMNKTDIIDHSFAVEWMQDFEAFQDALNQETTYVSNLTRSMSLVLDEFYSSLRVVGVSAV 246
Query: 901 TGAGMDDFFKAIEASADEYMQTYKADLDKRKAEKEQLEEERREKEMEKLRKDMESSQGGT 1080
G G+D+ F + ++A+EY + Y+ + ++ K E +++ +++E+LRKDM G+
Sbjct: 247 LGTGLDELFVQVTSAAEEYEREYRPEYERLKKSLANAESQQQREQLERLRKDM-----GS 301
Query: 1081 VVLNTGLKDRDAAEKMM-----------VEEEDDDDFKIEEDSDDAIDEDEEDE 1209
V L+ G +D+ ++ ++EED++ +D D + E+ +E
Sbjct: 302 VALDAGTA-KDSLSPVLHPSDLILTRGTLDEEDEEADSDTDDIDHRVTEESHEE 354
>sp|A4FUD1|GPN1_BOVIN GPN-loop GTPase 1 OS=Bos taurus GN=GPN1 PE=2 SV=1
Length = 373
Score = 360 bits (923), Expect = 3e-098
Identities = 176/350 (50%), Positives = 245/350 (70%), Gaps = 15/350 (4%)
Frame = +1
Query: 190 SSSSNFKKKPVIIIVVGMAGSGKTSFLHRLVCHTFDANKRGYVLNLDPAVMSLPFGANID 369
S +S + P ++V+GMAGSGKT+F+ RL + YV+NLDPAV +PF ANID
Sbjct: 10 SQASGGPRPPACLLVLGMAGSGKTTFVQRLTGYLHSQGCPPYVINLDPAVHEVPFPANID 69
Query: 370 IRDTVKYKEVMKQYNLGPNGGIMTSLNLFATKFDEVVSVIEKRADQLDYVLVDTPGQIEI 549
IRDTVKYKEVMKQY LGPNGGI+TSLNLFAT+FD+V+ IEK + YVL+DTPGQIE+
Sbjct: 70 IRDTVKYKEVMKQYGLGPNGGIVTSLNLFATRFDQVMKFIEKAQNMSKYVLIDTPGQIEV 129
Query: 550 FTWSASGAIITEAFASTFPTVVTYVVDTPRSTSPITFMSNMLYACSILYKTRLPLVLAFN 729
FTWSASG IITEA AS+FPT+V YV+DT RST+P+TFMSNMLYACSILYKT+LP ++ N
Sbjct: 130 FTWSASGTIITEALASSFPTIVIYVMDTSRSTNPVTFMSNMLYACSILYKTKLPFIVVMN 189
Query: 730 KTDVADHKFALEWMEDFEVFQAAIQSDNSYTSTLANSLSLSLYEFYRNIRSVGVSAITGA 909
KTD+ DH FA+EWM+DFE FQ A+ + +Y S L S+SL L EFY ++R VGVSA+ G
Sbjct: 190 KTDIIDHSFAVEWMQDFEAFQDALNQETTYVSNLTRSMSLVLDEFYSSLRVVGVSAVLGT 249
Query: 910 GMDDFFKAIEASADEYMQTYKADLDKRKAEKEQLEEERREKEMEKLRKDMESSQGGTVVL 1089
G+D+ F + ++ +EY + Y+ + ++ K + +++++++E+L+KDM G+V L
Sbjct: 250 GLDELFVQVASATEEYEREYRPEYERLKKSLASAQSQQQKEQLERLQKDM-----GSVAL 304
Query: 1090 NTGLKDRDAAEKM----------MVEEEDDDDFKIEEDSDDAIDEDEEDE 1209
+TG ++ + ++EED++ +D D + E+ +E
Sbjct: 305 DTGTATGSSSPVLDPSDLILTRGTLDEEDEEADSDTDDIDHRVTEESREE 354
>sp|Q8VCE2|GPN1_MOUSE GPN-loop GTPase 1 OS=Mus musculus GN=Gpn1 PE=1 SV=1
Length = 372
Score = 358 bits (918), Expect = 1e-097
Identities = 178/348 (51%), Positives = 243/348 (69%), Gaps = 15/348 (4%)
Frame = +1
Query: 196 SSNFKKKPVIIIVVGMAGSGKTSFLHRLVCHTFDANKRGYVLNLDPAVMSLPFGANIDIR 375
+S + PV ++V+GMAGSGKT+F+ RL H + YV+NLDPAV +PF ANIDIR
Sbjct: 12 ASRAPQPPVCLLVLGMAGSGKTTFVQRLTGHLHNKGCPPYVINLDPAVHEVPFPANIDIR 71
Query: 376 DTVKYKEVMKQYNLGPNGGIMTSLNLFATKFDEVVSVIEKRADQLDYVLVDTPGQIEIFT 555
DTVKYKEVMKQY LGPNGGI+TSLNLFAT+FD+V+ IEK + YVL+DTPGQIE+FT
Sbjct: 72 DTVKYKEVMKQYGLGPNGGIVTSLNLFATRFDQVMKFIEKAQNTFRYVLIDTPGQIEVFT 131
Query: 556 WSASGAIITEAFASTFPTVVTYVVDTPRSTSPITFMSNMLYACSILYKTRLPLVLAFNKT 735
WSASG IITEA AS+FPTVV YV+DT RST+P+TFMSNMLYACSILYKT+LP ++ NKT
Sbjct: 132 WSASGTIITEALASSFPTVVIYVMDTSRSTNPVTFMSNMLYACSILYKTKLPFIVVMNKT 191
Query: 736 DVADHKFALEWMEDFEVFQAAIQSDNSYTSTLANSLSLSLYEFYRNIRSVGVSAITGAGM 915
D+ DH FA+EWM+DFE FQ A+ + +Y S L S+SL L EFY ++R VGVSA+ G G
Sbjct: 192 DIIDHSFAVEWMQDFEAFQDALNQETTYVSNLTRSMSLVLDEFYSSLRVVGVSAVVGTGF 251
Query: 916 DDFFKAIEASADEYMQTYKADLDKRKAEKEQLEEERREKEMEKLRKDMESSQGGTVVLNT 1095
D+ + ++A+EY + Y+ + ++ K + ++++++E+LRKDM G+V L+
Sbjct: 252 DELCTQVTSAAEEYEREYRPEYERLKKSLANAQSNQQKEQLERLRKDM-----GSVALDP 306
Query: 1096 GLKDRDAAEKM----------MVEEEDDDDFKIEEDSDDAIDEDEEDE 1209
+A+ + ++EED++ +D D + E+ +E
Sbjct: 307 EAGKGNASPVLDPSDLILTRGTLDEEDEEADSDTDDIDHRVTEESREE 354
>sp|P47122|NPA3_YEAST GTPase NPA3 OS=Saccharomyces cerevisiae GN=NPA3 PE=1 SV=1
Length = 385
Score = 344 bits (880), Expect = 3e-093
Identities = 169/334 (50%), Positives = 233/334 (69%), Gaps = 14/334 (4%)
Frame = +1
Query: 226 IIVVGMAGSGKTSFLHRLVCHTFDANKRGYVLNLDPAVMSLPFGANIDIRDTVKYKEVMK 405
II +GMAGSGKT+F+ RL H YV+NLDPAV+ +P+GANIDIRD++KYK+VM+
Sbjct: 6 IICIGMAGSGKTTFMQRLNSHLRAEKTPPYVINLDPAVLRVPYGANIDIRDSIKYKKVME 65
Query: 406 QYNLGPNGGIMTSLNLFATKFDEVVSVIEKRADQLDYVLVDTPGQIEIFTWSASGAIITE 585
Y LGPNG I+TSLNLF+TK D+V+ ++E++ D+ ++DTPGQIE F WSASGAIITE
Sbjct: 66 NYQLGPNGAIVTSLNLFSTKIDQVIRLVEQKKDKFQNCIIDTPGQIECFVWSASGAIITE 125
Query: 586 AFASTFPTVVTYVVDTPRSTSPITFMSNMLYACSILYKTRLPLVLAFNKTDVADHKFALE 765
+FAS+FPTV+ Y+VDTPR++SP TFMSNMLYACSILYKT+LP+++ FNKTDV FA E
Sbjct: 126 SFASSFPTVIAYIVDTPRNSSPTTFMSNMLYACSILYKTKLPMIVVFNKTDVCKADFAKE 185
Query: 766 WMEDFEVFQAAIQSD----------NSYTSTLANSLSLSLYEFYRNIRSVGVSAITGAGM 915
WM DFE FQAAI+ D + Y S+L NS+SL L EFY + VGVS+ TG G
Sbjct: 186 WMTDFESFQAAIKEDQDLNGDNGLGSGYMSSLVNSMSLMLEEFYSQLDVVGVSSFTGDGF 245
Query: 916 DDFFKAIEASADEYMQTYKADLDKRKAEKEQLEEERREKEMEKLRKDMESSQGGTVVLNT 1095
D+F + ++ DEY Q YK + +K K++ EE R++K + L KD+ ++ + +
Sbjct: 246 DEFMQCVDKKVDEYDQYYKQEREKALNLKKKKEEMRKQKSLNGLMKDLGLNEKSSAAAS- 304
Query: 1096 GLKDRDAAEKMMVEEEDDDDFKIEEDSDDAIDED 1197
D D+ + + EED +D ++ D D+ ++ +
Sbjct: 305 ---DNDSIDAISDLEEDANDGLVDRDEDEGVERE 335
>sp|P46577|GPN1_CAEEL GPN-loop GTPase 1 homolog OS=Caenorhabditis elegans
GN=gop-2 PE=1 SV=1
Length = 355
Score = 304 bits (778), Expect = 2e-081
Identities = 160/329 (48%), Positives = 221/329 (67%), Gaps = 8/329 (2%)
Frame = +1
Query: 202 NFKKKPVIIIVVGMAGSGKTSFLHRLVCHTFDANKRGYVLNLDPAVMSLPFGANIDIRDT 381
N +KP I+V+GMAGSGKT+F+ RL YV+NLDPAV +P+ N+DIRDT
Sbjct: 26 NVNQKP-SILVLGMAGSGKTTFVQRLTAFLHARKTPPYVINLDPAVSKVPYPVNVDIRDT 84
Query: 382 VKYKEVMKQYNLGPNGGIMTSLNLFATKFDEVVSVIEKRADQLDYVLVDTPGQIEIFTWS 561
VKYKEVMK++ +GPNG IMT LNL T+FD+V+ +I KR+ L+DTPGQIE FTWS
Sbjct: 85 VKYKEVMKEFGMGPNGAIMTCLNLMCTRFDKVIELINKRSSDFSVCLLDTPGQIEAFTWS 144
Query: 562 ASGAIITEAFASTFPTVVTYVVDTPRSTSPITFMSNMLYACSILYKTRLPLVLAFNKTDV 741
ASG+IIT++ AS+ PTVV Y+VD+ R+T+P TFMSNMLYACSILY+T+LP ++ FNK D+
Sbjct: 145 ASGSIITDSLASSHPTVVMYIVDSARATNPTTFMSNMLYACSILYRTKLPFIVVFNKADI 204
Query: 742 ADHKFALEWMEDFEVFQAAIQ-SDNSYTSTLANSLSLSLYEFYRNIRSVGVSAITGAGMD 918
FAL+WM+DFE F A++ + +SY + L+ SLSL L EFY +++V VS+ TG G +
Sbjct: 205 VKPTFALKWMQDFERFDEALEDARSSYMNDLSRSLSLVLDEFYCGLKTVCVSSATGEGFE 264
Query: 919 DFFKAIEASADEYMQTYKADLDKRKAEKEQLEEERREKEMEKLRK-----DMESSQGGTV 1083
D AI+ S + Y + Y +K AEK+ L+EE R+K E+ K D+
Sbjct: 265 DVMTAIDESVEAYKKEYVPMYEKVLAEKKLLDEEERKKRDEETLKGKAVHDLNKVANPDE 324
Query: 1084 VLNTGLKDR-DAAEKMMVEEEDDDDFKIE 1167
L + L + D V+EE+++D ++E
Sbjct: 325 FLESELNSKIDRIHLGGVDEENEEDAELE 353
>sp|O42906|NPA3_SCHPO GTPase npa3 OS=Schizosaccharomyces pombe GN=npa3 PE=1
SV=1
Length = 367
Score = 297 bits (760), Expect = 3e-079
Identities = 154/347 (44%), Positives = 226/347 (65%), Gaps = 13/347 (3%)
Frame = +1
Query: 208 KKKPVIIIVVGMAGSGKTSFLHRLVCHTFDANKRGYVLNLDPAVMSLPFGANIDIRDTVK 387
+KKP IIVVGMAGSGKT+F+ +L H NK Y+LNLDPAV +LP+ ANIDIRDT+
Sbjct: 5 EKKPCAIIVVGMAGSGKTTFMQQLNAHLHSKNKPPYILNLDPAVRNLPYEANIDIRDTIN 64
Query: 388 YKEVMKQYNLGPNGGIMTSLNLFATKFDEVVSVIEKRADQLDYVLVDTPGQIEIFTWSAS 567
YKEVMKQYNLGPNGGIMTSLNLF TKFD+V+ ++EKRA +D++L+DTPGQIEIF WSAS
Sbjct: 65 YKEVMKQYNLGPNGGIMTSLNLFVTKFDQVLKILEKRAPTVDHILIDTPGQIEIFQWSAS 124
Query: 568 GAIITEAFASTFPTVVTYVVDTPRSTSPITFMSNMLYACSILYKTRLPLVLAFNKTDVAD 747
G+II + AS++PT + YVVDTPR+TS T+MS+MLYACS+LYK +LPL++ +NK DV D
Sbjct: 125 GSIICDTLASSWPTCIAYVVDTPRATSTSTWMSSMLYACSMLYKAKLPLIIVYNKCDVQD 184
Query: 748 HKFALEWMEDFEVFQAAIQSDNSYTSTLANSLSLSLYEFYRNIRSVGVSAITGAGMDDFF 927
+FA +WM DFE FQ A+ D +S A S + + S+ + DF
Sbjct: 185 SEFAKKWMTDFEEFQQAVTKDEGMSSEGATSGYMGSL-----VNSMSLMLEEFYRHLDFV 239
Query: 928 KAIEASA---DEYMQTYKADLDKRKAEKEQLEEERREKEMEKLRKDMESSQGGTVVLNTG 1098
+ D++++ KA + ++ E+E + E R KE+++ K+ + + ++
Sbjct: 240 SCSSVTGEGMDDFLEAVKAKV--KEYEEEYVPEMERMKEIQRQTKERQKEAQLSKLMKDM 297
Query: 1099 LKDRDAAEKMMVEEEDDDDFK---IEEDSDDAIDEDEEDEEMNRFYV 1230
+D + + + +D++ ++ D DD + ++ ++ + ++ V
Sbjct: 298 HVSKDKEDVGLTVSDAEDEYNGELVDPDEDDGLTAEDREDMIKQYRV 344
>sp|Q54NN1|DERL2_DICDI Probable derlin-2 homolog OS=Dictyostelium discoideum
GN=derl2 PE=3 SV=1
Length = 254
Score = 232 bits (590), Expect = 1e-059
Identities = 111/231 (48%), Positives = 162/231 (70%), Gaps = 6/231 (2%)
Frame = -1
Query: 2336 MAQAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNF 2157
MAQ E+WYK +PI+T+ Y+T VVT+V L ++ P LYLN LV +Y+FWRL TNF
Sbjct: 1 MAQPFEDWYKNLPIVTKIYMTGCVVTSVSVYLGLVGPLRLYLNFPLVFGKYEFWRLFTNF 60
Query: 2156 LYFRNMDLDFLFHMFFLARYCKLLEENSFRGKTADFLYMLLFGATALTGIVLVGGMIPYL 1977
++ + ++F FHM+FL R+ +LLEE+SFRG++AD+L+M +FG+ L +++ + Y
Sbjct: 61 FFYDEIGMNFFFHMYFLVRHSRLLEESSFRGRSADYLFMWIFGSFLL---LIMDAFLFYT 117
Query: 1976 SVSFSKIIFLSNSLTFMMVYVWSKQNPYIHMSFLGLFTFTAAYLPWVLLGFSVLVGASPW 1797
+ +K++FL+ S+ FM++YVWS++NP +H+SFLGLFTF+A YLPWV+L L
Sbjct: 118 KI-VTKVLFLAPSIAFMVIYVWSRRNPNMHISFLGLFTFSAPYLPWVILIMGYLFNHDLT 176
Query: 1796 GDLLGMIAGHAYYFLAFVYPRMTDRRPLKTPSFLKALF--ADEPVVVARPE 1650
DLLG +AGHAYYFL YP +++RR LKTP FLK L ++P+V A +
Sbjct: 177 TDLLGAVAGHAYYFLEDAYPLISNRRLLKTPGFLKNLMDGQEQPIVDAHQQ 227
>sp|Q9GZP9|DERL2_HUMAN Derlin-2 OS=Homo sapiens GN=DERL2 PE=1 SV=1
Length = 239
Score = 126 bits (315), Expect = 1e-027
Identities = 55/106 (51%), Positives = 78/106 (73%)
Frame = -1
Query: 2330 QAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNFLY 2151
Q++ Y Q+P ++R+Y TA V+TT LE+I+P+ LY NP L+ K +Q WRL+TNFL+
Sbjct: 4 QSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITNFLF 63
Query: 2150 FRNMDLDFLFHMFFLARYCKLLEENSFRGKTADFLYMLLFGATALT 2013
F + +FLF+M FL RYC++LEE SFRG+TADF++M LFG +T
Sbjct: 64 FGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMT 109
>sp|Q8BNI4|DERL2_MOUSE Derlin-2 OS=Mus musculus GN=Derl2 PE=2 SV=2
Length = 239
Score = 126 bits (315), Expect = 1e-027
Identities = 55/106 (51%), Positives = 78/106 (73%)
Frame = -1
Query: 2330 QAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNFLY 2151
Q++ Y Q+P ++R+Y TA V+TT LE+I+P+ LY NP L+ K +Q WRL+TNFL+
Sbjct: 4 QSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITNFLF 63
Query: 2150 FRNMDLDFLFHMFFLARYCKLLEENSFRGKTADFLYMLLFGATALT 2013
F + +FLF+M FL RYC++LEE SFRG+TADF++M LFG +T
Sbjct: 64 FGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMT 109
>sp|Q5RC74|DERL2_PONAB Derlin-2 OS=Pongo abelii GN=DERL2 PE=2 SV=1
Length = 239
Score = 126 bits (315), Expect = 1e-027
Identities = 55/106 (51%), Positives = 78/106 (73%)
Frame = -1
Query: 2330 QAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNFLY 2151
Q++ Y Q+P ++R+Y TA V+TT LE+I+P+ LY NP L+ K +Q WRL+TNFL+
Sbjct: 4 QSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITNFLF 63
Query: 2150 FRNMDLDFLFHMFFLARYCKLLEENSFRGKTADFLYMLLFGATALT 2013
F + +FLF+M FL RYC++LEE SFRG+TADF++M LFG +T
Sbjct: 64 FGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMT 109
>sp|Q0P5E4|DERL3_BOVIN Derlin-3 OS=Bos taurus GN=DERL3 PE=2 SV=1
Length = 231
Score = 126 bits (314), Expect = 1e-027
Identities = 65/177 (36%), Positives = 105/177 (59%), Gaps = 13/177 (7%)
Frame = -1
Query: 2330 QAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNFLY 2151
Q + + Q+P +TR+Y A V+TT LE++SP+ LY NP LV +++Q WRL+TNFL+
Sbjct: 4 QGLATEFLQVPAVTRTYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLITNFLF 63
Query: 2150 FRNMDLDFLFHMFFLARYCKLLEENSFRGKTADFLYMLLFGATALTGIVLVGGMIPYLSV 1971
F + F F+M F+ RYC++LEE SFRG+TADF++M LFG +T + L+G +
Sbjct: 64 FGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFLGQA 123
Query: 1970 SFSKIIFL----SNSLTFMMVYVWSKQNPYIHMSFLGLFTFTAAYLPWVLLGFSVLV 1812
+ ++++ S + + + Q P++ + +GL +LLG S+LV
Sbjct: 124 LTAMLVYVWSRRSPGVRVNFFGLLTFQAPFLPWALMGL---------PMLLGNSILV 171
>sp|Q96Q80|DERL3_HUMAN Derlin-3 OS=Homo sapiens GN=DERL3 PE=1 SV=2
Length = 235
Score = 126 bits (314), Expect = 1e-027
Identities = 55/114 (48%), Positives = 80/114 (70%)
Frame = -1
Query: 2330 QAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNFLY 2151
Q + + Q+P +TR+Y A V+TT LE++SP+ LY NP LV +++Q WRLVTNFL+
Sbjct: 4 QGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTNFLF 63
Query: 2150 FRNMDLDFLFHMFFLARYCKLLEENSFRGKTADFLYMLLFGATALTGIVLVGGM 1989
F + F F+M F+ RYC++LEE SFRG+TADF++M LFG +T + L+G +
Sbjct: 64 FGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSL 117
>sp|Q9D8K3|DERL3_MOUSE Derlin-3 OS=Mus musculus GN=Derl3 PE=2 SV=1
Length = 228
Score = 119 bits (296), Expect = 2e-025
Identities = 51/114 (44%), Positives = 77/114 (67%)
Frame = -1
Query: 2330 QAVEEWYKQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNFLY 2151
Q + + Q+P +TR+Y A V+TT LE++SP+ LY NP LV +++Q WRL+T FL+
Sbjct: 4 QRLAAGFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLITTFLF 63
Query: 2150 FRNMDLDFLFHMFFLARYCKLLEENSFRGKTADFLYMLLFGATALTGIVLVGGM 1989
F + F F+M F+ RYC++LEE SFRG+ ADF++M LFG +T + +G +
Sbjct: 64 FGPLGFGFFFNMLFVFRYCRMLEEGSFRGRKADFVFMFLFGGVLMTLLGFLGSL 117
>sp|Q21997|DERL2_CAEEL Derlin-2 OS=Caenorhabditis elegans GN=der-2 PE=2 SV=2
Length = 237
Score = 112 bits (279), Expect = 2e-023
Identities = 48/98 (48%), Positives = 69/98 (70%)
Frame = -1
Query: 2309 KQMPIITRSYLTAAVVTTVGCSLEIISPYNLYLNPTLVVKQYQFWRLVTNFLYFRNMDLD 2130
++MP +TR Y A V+ T LE ++P++LY N L++++YQFWRL+T+F +F +
Sbjct: 9 EEMPPVTRFYTGACVLLTTAVHLEFVTPFHLYFNWELIIRKYQFWRLITSFCFFGSFGFS 68
Query: 2129 FLFHMFFLARYCKLLEENSFRGKTADFLYMLLFGATAL 2016
FLF+M F RYC +LEE SFRG+ ADF+YM LFGA +
Sbjct: 69 FLFNMIFTYRYCMMLEEGSFRGRRADFVYMFLFGAVLM 106
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,759,707,213
Number of Sequences: 518415
Number of Extensions: 54759707213
Number of Successful Extensions: 366332288
Number of sequences better than 0.0: 0
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