BLASTX 7.6.2
Query= UN13377 /QuerySize=940
(939 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54QP6|OSB8_DICDI Oxysterol-binding protein 8 OS=Dictyosteliu... 122 5e-027
sp|O13944|YEH1_SCHPO Oxysterol-binding protein homolog C23H4.01c... 79 5e-014
sp|P35845|OSH1_YEAST Oxysterol-binding protein homolog 1 OS=Sacc... 72 5e-012
sp|Q8K4M9|OSBL1_RAT Oxysterol-binding protein-related protein 1 ... 65 6e-010
sp|Q9BXW6|OSBL1_HUMAN Oxysterol-binding protein-related protein ... 65 8e-010
sp|Q91XL9|OSBL1_MOUSE Oxysterol-binding protein-related protein ... 64 1e-009
sp|Q9BZF2|OSBL7_HUMAN Oxysterol-binding protein-related protein ... 63 2e-009
sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2 OS=Sacc... 63 3e-009
sp|Q8BX94|OSBL2_MOUSE Oxysterol-binding protein-related protein ... 62 7e-009
sp|Q9H1P3|OSBL2_HUMAN Oxysterol-binding protein-related protein ... 60 2e-008
sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c... 58 1e-007
sp|P22059|OSBP1_HUMAN Oxysterol-binding protein 1 OS=Homo sapien... 52 5e-006
sp|P16258|OSBP1_RABIT Oxysterol-binding protein 1 OS=Oryctolagus... 52 5e-006
sp|Q3B7Z2|OSBP1_MOUSE Oxysterol-binding protein 1 OS=Mus musculu... 52 7e-006
>sp|Q54QP6|OSB8_DICDI Oxysterol-binding protein 8 OS=Dictyostelium discoideum
GN=osbH PE=1 SV=1
Length = 402
Score = 122 bits (304), Expect = 5e-027
Identities = 73/199 (36%), Positives = 104/199 (52%), Gaps = 11/199 (5%)
Frame = -2
Query: 938 LIFGRTWVDSPGEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGK 759
+I G W+D G++V+ N TTG K VL F GW G+GRY V G + + + + +TGK
Sbjct: 203 IIIGSLWLDHYGDLVIENHTTGSKAVLKFAKSGWLGAGRYGVTGEIVDCEGDVRYRITGK 262
Query: 758 WNEKIG-YQPCDTEGEPLPGTELKEVWHVADVPKNDKFQYTHFAHK--INSFDTAPSKLL 588
WNE I +Q D T L W + P N+KF + + + I+ D L
Sbjct: 263 WNESIQLFQVMDNGSSSTTSTCL---WEASKEPINNKFLFPRWVEENVIDLNDEYKKILP 319
Query: 587 ASDSRLRPDRYALEQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITFT 408
+DSRLR DR ALE+G+L A EKH+LEE+QR +KR R + +++ F D+ F
Sbjct: 320 VTDSRLRADRIALEEGNLDVAAKEKHNLEEKQREDKRQRVAENKEWETAQFKKVDDAKFG 379
Query: 407 PWGDIEIYQYNGKYNEHRD 351
+ Y G Y E R+
Sbjct: 380 -----YRWNYCGNYWEERE 393
>sp|O13944|YEH1_SCHPO Oxysterol-binding protein homolog C23H4.01c
OS=Schizosaccharomyces pombe GN=SPAC23H4.01c PE=1 SV=2
Length = 945
Score = 79 bits (192), Expect = 5e-014
Identities = 59/172 (34%), Positives = 85/172 (49%), Gaps = 16/172 (9%)
Frame = -2
Query: 929 GRTWVDSPGEMVMTNLTTGDKVVLYFQPCGWFGSGRYE---VDGYVYSADEEPKIMMTGK 759
G +V+ M + + TTGDK V+ F+ G F SGR E V + +E+PK + GK
Sbjct: 741 GEKYVEPYDHMEIVDETTGDKAVIRFKSGGMF-SGRSEDVLVTVIRSNGEEDPKCLQ-GK 798
Query: 758 WNEKIGYQPCDTEGEPLPGTELKEVWHV---ADVPKNDKFQYTHFAHKINSF-DTAPSKL 591
W + + D G ++ +W V D P+ D T FA ++N D KL
Sbjct: 799 WTSHLDFVNTD------EGNVIERIWEVGPLVDKPE-DHCGMTVFAAQMNEITDLEKDKL 851
Query: 590 LASDSRLRPDRYALEQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWF 435
+D+RLRPD+ E DL A K LE++QR ++ E K K+ PRWF
Sbjct: 852 PPTDTRLRPDQRYRENNDLDHAEPLKLELEQKQRERRKEMEEKDIKWEPRWF 903
>sp|P35845|OSH1_YEAST Oxysterol-binding protein homolog 1 OS=Saccharomyces
cerevisiae GN=OSH1 PE=1 SV=4
Length = 1188
Score = 72 bits (175), Expect = 5e-012
Identities = 44/121 (36%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Frame = -2
Query: 725 TEGEPLPGTELKEVWHVADVPKNDKFQYTHFAHKINSFDTAPSKLLA-SDSRLRPDRYAL 549
T G L G++ +W + P + F T FA +N+ LA +DSRLRPD+ A+
Sbjct: 1058 TGGPKLDGSKFL-IWKANERP-SVPFNLTSFALTLNALPPHLIPYLAPTDSRLRPDQRAM 1115
Query: 548 EQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITFTPWGDIEIYQYNGK 369
E G+ KA +EKH +E +QRA K+ RE KG+++ P+WF + P +++NG+
Sbjct: 1116 ENGEYDKAAAEKHRVEVKQRAAKKEREQKGEEYRPKWFVQEEH----PVTKSLYWKFNGE 1171
Query: 368 Y 366
Y
Sbjct: 1172 Y 1172
Score = 60 bits (144), Expect = 2e-008
Identities = 30/95 (31%), Positives = 51/95 (53%)
Frame = -2
Query: 938 LIFGRTWVDSPGEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGK 759
++ G+ VD+ G++ +TN TTGD +L+++ GW +G YEV G V++ D++ ++ G
Sbjct: 970 ILMGKPQVDNSGDVKVTNHTTGDYCMLHYKAHGWTSAGAYEVRGEVFNKDDKKLWVLGGH 1029
Query: 758 WNEKIGYQPCDTEGEPLPGTELKEVWHVADVPKND 654
WN+ I + G L +K PK D
Sbjct: 1030 WNDSIYGKKVTARGGELTLDRIKTANSATGGPKLD 1064
>sp|Q8K4M9|OSBL1_RAT Oxysterol-binding protein-related protein 1 OS=Rattus
norvegicus GN=Osbpl1a PE=1 SV=1
Length = 950
Score = 65 bits (157), Expect = 6e-010
Identities = 38/118 (32%), Positives = 61/118 (51%), Gaps = 9/118 (7%)
Frame = -2
Query: 710 LPGTELKEVWHVADVPKN--DKFQYTHFAHKINSFDTAPSKLL-ASDSRLRPDRYALEQG 540
+PG+ L +W +A P N + +T FA +N D ++ +D RLRPD A+E G
Sbjct: 827 IPGSAL--LWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMETVIPKTDCRLRPDIRAMENG 884
Query: 539 DLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITFTPWGDIEIYQYNGKY 366
++ +A EK LEE+QRA ++ R + + RWF P+ + + Y+G Y
Sbjct: 885 EIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGP----NPYSGAQDWIYSGSY 938
Score = 59 bits (141), Expect = 4e-008
Identities = 24/63 (38%), Positives = 38/63 (60%)
Frame = -2
Query: 938 LIFGRTWVDSPGEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGK 759
+I G+ W++ G + + N TGDK VL F+PCG FG ++V+GY+ ++ + GK
Sbjct: 715 IIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGK 774
Query: 758 WNE 750
W E
Sbjct: 775 WTE 777
>sp|Q9BXW6|OSBL1_HUMAN Oxysterol-binding protein-related protein 1 OS=Homo
sapiens GN=OSBPL1A PE=1 SV=2
Length = 950
Score = 65 bits (156), Expect = 8e-010
Identities = 39/118 (33%), Positives = 61/118 (51%), Gaps = 9/118 (7%)
Frame = -2
Query: 710 LPGTELKEVWHVADVPKN--DKFQYTHFAHKINSFD-TAPSKLLASDSRLRPDRYALEQG 540
+PG+ L +W +A P N + +T FA +N D S + +D RLRPD A+E G
Sbjct: 827 IPGSVL--LWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENG 884
Query: 539 DLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITFTPWGDIEIYQYNGKY 366
++ +A EK LEE+QRA ++ R + + RWF P+ + + Y+G Y
Sbjct: 885 EIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGP----NPYNGAQDWIYSGSY 938
Score = 59 bits (141), Expect = 4e-008
Identities = 24/63 (38%), Positives = 38/63 (60%)
Frame = -2
Query: 938 LIFGRTWVDSPGEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGK 759
+I G+ W++ G + + N TGDK VL F+PCG FG ++V+GY+ ++ + GK
Sbjct: 715 IIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGK 774
Query: 758 WNE 750
W E
Sbjct: 775 WTE 777
>sp|Q91XL9|OSBL1_MOUSE Oxysterol-binding protein-related protein 1 OS=Mus
musculus GN=Osbpl1a PE=1 SV=2
Length = 950
Score = 64 bits (154), Expect = 1e-009
Identities = 38/118 (32%), Positives = 60/118 (50%), Gaps = 9/118 (7%)
Frame = -2
Query: 710 LPGTELKEVWHVADVPKN--DKFQYTHFAHKINSFDTAPSKLL-ASDSRLRPDRYALEQG 540
+PG+ L +W +A P N + +T FA +N D ++ +D RLRPD A+E G
Sbjct: 827 IPGSVL--LWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMESVIPKTDCRLRPDIRAMENG 884
Query: 539 DLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITFTPWGDIEIYQYNGKY 366
++ A EK LEE+QRA ++ R + + RWF P+ + + Y+G Y
Sbjct: 885 EIDLASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGP----NPYSGAQDWIYSGSY 938
Score = 59 bits (141), Expect = 4e-008
Identities = 24/63 (38%), Positives = 38/63 (60%)
Frame = -2
Query: 938 LIFGRTWVDSPGEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGK 759
+I G+ W++ G + + N TGDK VL F+PCG FG ++V+GY+ ++ + GK
Sbjct: 715 IIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGK 774
Query: 758 WNE 750
W E
Sbjct: 775 WTE 777
>sp|Q9BZF2|OSBL7_HUMAN Oxysterol-binding protein-related protein 7 OS=Homo
sapiens GN=OSBPL7 PE=2 SV=1
Length = 842
Score = 63 bits (152), Expect = 2e-009
Identities = 47/183 (25%), Positives = 86/183 (46%), Gaps = 13/183 (7%)
Frame = -2
Query: 938 LIFGRTWVDSPGEMVMTNLTTGD-KVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTG 762
++ G+ W++ GE+++ N + F ++ S +EV G V S + G
Sbjct: 644 VLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLSRSGRVLHRLFG 703
Query: 761 KWNEKIGYQPCDTEGEPLPGTELKEVWHVADVPKNDK--FQYTHFAHKINSFDTAPSKLL 588
KW+E + Y+ P PG + +W +P + + F +T FA ++N + L
Sbjct: 704 KWHEGL-YR------GPTPGGQC--IWKPNSMPPDHERNFGFTQFALELNELTAELKRSL 754
Query: 587 AS-DSRLRPDRYALEQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITF 411
S D+RLRPD+ LE+G++ A ++K +E+ QR ++ E R+F + +
Sbjct: 755 PSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFFRRQTDSSG 814
Query: 410 TPW 402
W
Sbjct: 815 KEW 817
>sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2 OS=Saccharomyces
cerevisiae GN=OSH2 PE=1 SV=1
Length = 1283
Score = 63 bits (151), Expect = 3e-009
Identities = 40/112 (35%), Positives = 58/112 (51%), Gaps = 14/112 (12%)
Frame = -2
Query: 686 VWHVADVPKNDKFQYTHFAHKINSFDTAPSK-----LLASDSRLRPDRYALEQGDLSKAG 522
+W D P+ + F T FA +N AP L +D+RLRPD+ A+E G +AG
Sbjct: 1165 IWKANDRPE-EPFNLTPFAITLN----APQPHLLPWLPPTDTRLRPDQRAMEDGRYDEAG 1219
Query: 521 SEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITFTPWGDIEIYQYNGKY 366
EK +EE+QRA +R RE ++ P+WF P + ++Y GKY
Sbjct: 1220 DEKFRVEEKQRAARRKREENNLEYHPQWFVRDTH----PITKAKYWRYTGKY 1267
Score = 59 bits (140), Expect = 6e-008
Identities = 27/65 (41%), Positives = 39/65 (60%)
Frame = -2
Query: 938 LIFGRTWVDSPGEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGK 759
++ G VD+ GE+ + N TTGD LYF+ GW SG YE+ G VY+ ++ ++ G
Sbjct: 1066 ILIGNPQVDNHGEVNVVNHTTGDHCKLYFKARGWRSSGAYEITGEVYNKKKQKVWILGGH 1125
Query: 758 WNEKI 744
WNE I
Sbjct: 1126 WNEAI 1130
>sp|Q8BX94|OSBL2_MOUSE Oxysterol-binding protein-related protein 2 OS=Mus
musculus GN=Osbpl2 PE=2 SV=1
Length = 484
Score = 62 bits (148), Expect = 7e-009
Identities = 27/74 (36%), Positives = 43/74 (58%), Gaps = 1/74 (1%)
Frame = -2
Query: 938 LIFGRTWVDSPGEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGK 759
+I G+ W++ G + + N TGDK +L+F+PCG FG + V+GY+ + + +M GK
Sbjct: 242 VILGQLWIEQYGIVEIVNHRTGDKCILHFKPCGLFGKELHRVEGYIQDKNRKKLFIMYGK 301
Query: 758 WNEKI-GYQPCDTE 720
W E + G P E
Sbjct: 302 WTECLWGIDPASYE 315
Score = 59 bits (140), Expect = 6e-008
Identities = 36/120 (30%), Positives = 59/120 (49%), Gaps = 9/120 (7%)
Frame = -2
Query: 710 LPGTELKEVWHVADVPKN--DKFQYTHFAHKINSFDTAPSKLL-ASDSRLRPDRYALEQG 540
+PG++L +W + P N + +T F +N ++ K L +D RLRPD +E G
Sbjct: 361 IPGSKL--LWRINSRPPNSAQMYNFTSFTVSLNELESGMEKTLPPTDCRLRPDIRGMENG 418
Query: 539 DLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITFTPWGDIEIYQYNGKYNE 360
++ A EK LEE+QR ++ R + ++ RWF + P+ + Y G Y E
Sbjct: 419 NMDLASQEKERLEEKQREARKERAKEDAEWRTRWFSPGN----NPYTGAPDWLYAGHYFE 474
>sp|Q9H1P3|OSBL2_HUMAN Oxysterol-binding protein-related protein 2 OS=Homo
sapiens GN=OSBPL2 PE=1 SV=1
Length = 480
Score = 60 bits (144), Expect = 2e-008
Identities = 33/95 (34%), Positives = 51/95 (53%), Gaps = 5/95 (5%)
Frame = -2
Query: 710 LPGTELKEVWHVADVPKN--DKFQYTHFAHKINSFDTAPSKLL-ASDSRLRPDRYALEQG 540
+PG++L +W + P N + +T F +N +T K L +D RLRPD +E G
Sbjct: 357 IPGSKL--LWRINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENG 414
Query: 539 DLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWF 435
++ A EK LEE+QR +R R + ++ RWF
Sbjct: 415 NMDLASQEKERLEEKQREARRERAKEEAEWQTRWF 449
>sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c
OS=Schizosaccharomyces pombe GN=SPBC2F12.05c PE=1 SV=2
Length = 1310
Score = 58 bits (138), Expect = 1e-007
Identities = 37/104 (35%), Positives = 56/104 (53%), Gaps = 6/104 (5%)
Frame = -2
Query: 650 FQYTHFAHKINSFDTAPSKLL-ASDSRLRPDRYALEQGDLSKAGSEKHSLEERQRAEKRT 474
F T FA +N+ L +D+RLRPD+ A+E G A SEK+ LEE+QR ++R
Sbjct: 1192 FNLTPFAISLNALTPQLKPWLPPTDTRLRPDQRAMENGQYDLAASEKNRLEEKQRKKRRM 1251
Query: 473 RET-KGQKFTPRWFDLTDEITFTPWGDIEIYQYNGKYNEHRDTA 345
RE + ++PRWF P + +Q+N +Y + R+ A
Sbjct: 1252 REQGEMPPWSPRWFSAAKH----PVTGEDYWQFNNEYWKIREEA 1291
>sp|P22059|OSBP1_HUMAN Oxysterol-binding protein 1 OS=Homo sapiens GN=OSBP PE=1
SV=1
Length = 807
Score = 52 bits (123), Expect = 5e-006
Identities = 30/84 (35%), Positives = 49/84 (58%), Gaps = 9/84 (10%)
Frame = -2
Query: 686 VWHVADVPKN--DKFQYTHFAHKINSFD--TAPSKLLASDSRLRPDRYALEQGDLSKAGS 519
+W +PKN + + ++ A +N+++ TAP +DSRLRPD+ +E G +A +
Sbjct: 680 LWKRNPLPKNAENMYYFSELALTLNAWESGTAP-----TDSRLRPDQRLMENGRWDEANA 734
Query: 518 EKHSLEERQRAEKRTRETKGQKFT 447
EK LEE+QR ++ RE + K T
Sbjct: 735 EKQRLEEKQRLSRKKREAEAMKAT 758
>sp|P16258|OSBP1_RABIT Oxysterol-binding protein 1 OS=Oryctolagus cuniculus
GN=OSBP PE=1 SV=1
Length = 809
Score = 52 bits (123), Expect = 5e-006
Identities = 30/84 (35%), Positives = 49/84 (58%), Gaps = 9/84 (10%)
Frame = -2
Query: 686 VWHVADVPKN--DKFQYTHFAHKINSFD--TAPSKLLASDSRLRPDRYALEQGDLSKAGS 519
+W +PKN + + ++ A +N+++ TAP +DSRLRPD+ +E G +A +
Sbjct: 682 LWKRNPLPKNAENMYYFSELALTLNAWEGGTAP-----TDSRLRPDQRLMENGRWDEANA 736
Query: 518 EKHSLEERQRAEKRTRETKGQKFT 447
EK LEE+QR ++ RE + K T
Sbjct: 737 EKQRLEEKQRLSRKKREAEAMKAT 760
>sp|Q3B7Z2|OSBP1_MOUSE Oxysterol-binding protein 1 OS=Mus musculus GN=Osbp PE=1
SV=2
Length = 751
Score = 52 bits (122), Expect = 7e-006
Identities = 30/84 (35%), Positives = 49/84 (58%), Gaps = 9/84 (10%)
Frame = -2
Query: 686 VWHVADVPKN--DKFQYTHFAHKINSFD--TAPSKLLASDSRLRPDRYALEQGDLSKAGS 519
+W +PKN + + ++ A +N+++ TAP +DSRLRPD+ +E G +A +
Sbjct: 624 LWKRNPLPKNAENMYYFSELALTLNAWEGGTAP-----TDSRLRPDQRLMENGRWDEANA 678
Query: 518 EKHSLEERQRAEKRTRETKGQKFT 447
EK LEE+QR ++ RE + K T
Sbjct: 679 EKQRLEEKQRLSRKKREAEAAKAT 702
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,759,707,213
Number of Sequences: 518415
Number of Extensions: 54759707213
Number of Successful Extensions: 366332288
Number of sequences better than 0.0: 0
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