BLASTX 7.6.2
Query= UN13604 /QuerySize=1266
(1265 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabi... 241 1e-062
sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase D... 236 2e-061
sp|Q55A09|Y9963_DICDI Probable serine/threonine-protein kinase D... 203 2e-051
sp|P42686|SRK1_SPOLA Tyrosine-protein kinase isoform SRK1 OS=Spo... 177 2e-043
sp|Q03526|ITK_MOUSE Tyrosine-protein kinase ITK/TSK OS=Mus muscu... 173 2e-042
sp|Q08881|ITK_HUMAN Tyrosine-protein kinase ITK/TSK OS=Homo sapi... 173 4e-042
sp|Q9TTY2|FER_CANFA Tyrosine-protein kinase Fer OS=Canis familia... 172 5e-042
sp|P42690|SRK4_SPOLA Tyrosine-protein kinase isoform SRK4 OS=Spo... 170 2e-041
sp|P09760|FER_RAT Tyrosine-protein kinase Fer (Fragment) OS=Ratt... 169 3e-041
sp|P42680|TEC_HUMAN Tyrosine-protein kinase Tec OS=Homo sapiens ... 169 3e-041
sp|P24604|TEC_MOUSE Tyrosine-protein kinase Tec OS=Mus musculus ... 169 6e-041
sp|P70451|FER_MOUSE Tyrosine-protein kinase Fer OS=Mus musculus ... 168 1e-040
sp|P42682|TXK_MOUSE Tyrosine-protein kinase TXK OS=Mus musculus ... 165 7e-040
sp|P42681|TXK_HUMAN Tyrosine-protein kinase TXK OS=Homo sapiens ... 164 1e-039
sp|P42688|SRK2_SPOLA Tyrosine-protein kinase SRK2 (Fragment) OS=... 160 3e-038
sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kina... 156 3e-037
sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase ki... 156 5e-037
sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase ki... 156 5e-037
sp|A7J1T0|M313B_XENLA Mitogen-activated protein kinase kinase ki... 153 4e-036
sp|O43283|M3K13_HUMAN Mitogen-activated protein kinase kinase ki... 152 6e-036
>sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabidopsis thaliana
GN=HT1 PE=1 SV=1
Length = 390
Score = 241 bits (613), Expect = 1e-062
Identities = 115/271 (42%), Positives = 178/271 (65%), Gaps = 5/271 (1%)
Frame = +3
Query: 87 WEINLQHLKFGHKIASGSYGDLYKGTYCSQEVAIKVLK----PERLDSELEKEFAQEVFI 254
W +L L G+K ASG++ +Y+G Y + VA+K+++ E ++LE++F EV +
Sbjct: 79 WTADLSQLFIGNKFASGAHSRIYRGIYKQRAVAVKMVRIPTHKEETRAKLEQQFKSEVAL 138
Query: 255 MRKVRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGV-FKLPALLKVAIDICK 431
+ ++ H N+VQFI AC KPP CI+TE+M G++ YL+K++ + +L++A+DI +
Sbjct: 139 LSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISR 198
Query: 432 GMNYLHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGTYRWMAPEVI 611
GM YLH +IHRDLK+ NLL+++ VKVADFG + ++ Q GTYRWMAPE+I
Sbjct: 199 GMEYLHSQGVIHRDLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGNMGTYRWMAPEMI 258
Query: 612 EHKPYDHKADVFSYGIVLWELLTGKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMREL 791
+ KPY K DV+S+GIVLWEL T +P++ MTP+QAA V +K RP + P + L
Sbjct: 259 KEKPYTRKVDVYSFGIVLWELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALAHL 318
Query: 792 MERLWEKDPTLRPDFSEIIDQLQEISKEVED 884
++R W ++P+ RPDFS I+ L++ + V++
Sbjct: 319 IKRCWSENPSKRPDFSNIVAVLEKYDECVKE 349
>sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase DDB_G0267514
OS=Dictyostelium discoideum GN=DDB_G0267514 PE=3 SV=1
Length = 916
Score = 236 bits (602), Expect = 2e-061
Identities = 110/260 (42%), Positives = 174/260 (66%), Gaps = 1/260 (0%)
Frame = +3
Query: 90 EINLQHLKFGHKIASGSYGDLYKGTYCSQEVAIKVLK-PERLDSELEKEFAQEVFIMRKV 266
EI+ LK K+ G++G +YKG + VAIK +K E +++++ +EF +E+ I+ ++
Sbjct: 656 EISFSELKISSKLGEGTFGVVYKGLWRGSSVAIKQIKINEDVNNQVLEEFRKELTILSRL 715
Query: 267 RHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNYL 446
RH N+V + ACT PP+LC +TE++PGGS+YD LH +K + K+AI I +GMNYL
Sbjct: 716 RHPNIVLLMAACTAPPNLCFITEYLPGGSLYDALHSKKIKMNMQLYKKLAIQIAQGMNYL 775
Query: 447 HQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGTYRWMAPEVIEHKPY 626
H + +IHRD+K+ NLL+DEH VK+ DFG++++K+++ MT G+ WM+PE++ + Y
Sbjct: 776 HLSGVIHRDIKSLNLLLDEHMNVKICDFGLSKLKSKSTEMTKSIGSPIWMSPELLMGEDY 835
Query: 627 DHKADVFSYGIVLWELLTGKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMRELMERLW 806
K DV+++GI+LWEL TG++PY + +Q A+ V K LRP I ++ L++ W
Sbjct: 836 TEKVDVYAFGIILWELGTGELPYSGLDSVQLALAVTTKSLRPPIPNAWPYQLSHLIQACW 895
Query: 807 EKDPTLRPDFSEIIDQLQEI 866
+DP RP F+EI++ L EI
Sbjct: 896 HQDPLKRPSFTEILNLLNEI 915
>sp|Q55A09|Y9963_DICDI Probable serine/threonine-protein kinase DDB_G0272254
OS=Dictyostelium discoideum GN=DDB_G0272254 PE=3 SV=1
Length = 1331
Score = 203 bits (516), Expect = 2e-051
Identities = 109/275 (39%), Positives = 167/275 (60%), Gaps = 12/275 (4%)
Frame = +3
Query: 57 VSIPTDGTDVWEINLQHLKFGHKIASGSYGDLYKGTYCSQEVAIKVL--KPERLDSELEK 230
V++P + V IN +K +I G + + KG + ++VA+K L ++ E+ +
Sbjct: 1057 VTLPI-SSSVTMINYSDIKIDKEIGKGHFSKVLKGNWKGKDVAVKKLNSNKDKAREEMIQ 1115
Query: 231 EFAQEVFIMRKVRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLH----KQKGVFKLP 398
EF EV ++ ++H N+V G P +CIV EF+P G++++ +H +Q+ KL
Sbjct: 1116 EFKAEVELLGSLQHPNLVTCYGYSLNP--MCIVMEFLPSGNLFELIHSKPSEQQQSIKLD 1173
Query: 399 A--LLKVAIDICKGMNYLHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTA 572
+ +L +A DI +GM +LH NIIHRDLK++NLLMD+H +K+AD G+AR + T MT
Sbjct: 1174 STLILAIAFDIARGMQHLHTRNIIHRDLKSSNLLMDKHFNIKIADLGIARETSFTQTMTT 1233
Query: 573 ETGTYRWMAPEVIEHKPYDHKADVFSYGIVLWELLTGKIPYEYMTPLQAAVGVVQKGLRP 752
GT W APE++ H+ Y+ KADV+SY IVL+ELLTG+ PY+ + P+ A + V KGLRP
Sbjct: 1234 -IGTVAWTAPEILRHESYNQKADVYSYAIVLYELLTGEEPYQGIPPMNAGILVASKGLRP 1292
Query: 753 TIAKKTHPKMRELMERLWEKDPTLRPDFSEIIDQL 857
+ P ++L+ W +DP RP F EI + L
Sbjct: 1293 ELPDNCDPNWKKLVVWCWSEDPNKRPSFEEITNYL 1327
>sp|P42686|SRK1_SPOLA Tyrosine-protein kinase isoform SRK1 OS=Spongilla
lacustris GN=SRK1 PE=2 SV=1
Length = 505
Score = 177 bits (448), Expect = 2e-043
Identities = 99/264 (37%), Positives = 151/264 (57%), Gaps = 10/264 (3%)
Frame = +3
Query: 87 WEINLQHLKFGHKIASGSYGDLYKGTY-CSQEVAIKVLKPERLDSELEKEFAQEVFIMRK 263
WEI +K ++ +G +G++++G + + VA+K LKP + E EF QE IM++
Sbjct: 233 WEIEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMSVE---EFLQEASIMKR 289
Query: 264 VRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNY 443
+RH ++Q CTK + IVTE M GS+ +YL + GV K+ L+ VA + GM+Y
Sbjct: 290 LRHPKLIQLYAVCTKEEPIYIVTELMKYGSLLEYLRGEDGVLKIEQLVDVAAQVASGMSY 349
Query: 444 LHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGT---YRWMAPEVIE 614
L Q N IHRDL A N+L+ EH + KVADFG+ARV + A TG +W APE
Sbjct: 350 LEQQNYIHRDLAARNILVGEHGICKVADFGLARV-IDEEIYEAHTGAKFPIKWTAPEAAM 408
Query: 615 HKPYDHKADVFSYGIVLWELLT-GKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMREL 791
+ + K+DV+S+G+VL+E++T G+ PY MT + + +Q+ R + ++
Sbjct: 409 YNRFTIKSDVWSFGVVLYEIITYGRFPYPGMTNPE-VLEKIQQNYRMPCPANCPKQFHDI 467
Query: 792 MERLWEKDPTLRPDFSEIIDQLQE 863
M W +DP RP F + QL+E
Sbjct: 468 MLDCWREDPASRPTFETLQWQLEE 491
>sp|Q03526|ITK_MOUSE Tyrosine-protein kinase ITK/TSK OS=Mus musculus GN=Itk PE=1
SV=1
Length = 625
Score = 173 bits (438), Expect = 2e-042
Identities = 95/267 (35%), Positives = 155/267 (58%), Gaps = 10/267 (3%)
Frame = +3
Query: 87 WEINLQHLKFGHKIASGSYGDLYKGTYCSQE-VAIKVLKPERLDSELEKEFAQEVFIMRK 263
W I L F +I SG +G ++ G + +++ VAIK ++ + E++F +E +M K
Sbjct: 361 WVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMS---EEDFIEEAEVMMK 417
Query: 264 VRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNY 443
+ H +VQ G C + +C+V EFM G + DYL Q+G+F LL + +D+C+GM Y
Sbjct: 418 LSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAY 477
Query: 444 LHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGT---YRWMAPEVIE 614
L + +IHRDL A N L+ E++V+KV+DFG+ R T+ TGT +W +PEV
Sbjct: 478 LEKACVIHRDLAARNCLVGENQVIKVSDFGMTRF-VLDDQYTSSTGTKFPVKWASPEVFS 536
Query: 615 HKPYDHKADVFSYGIVLWELLT-GKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMREL 791
Y K+DV+S+G+++WE+ + GKIPYE + + V + G R + + ++
Sbjct: 537 FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSE-VVEDISTGFRLYKPRLASCHVYQI 595
Query: 792 MERLWEKDPTLRPDFSEIIDQLQEISK 872
M W++ P RP FS+++ QL EI++
Sbjct: 596 MNHCWKEKPEDRPPFSQLLSQLAEIAE 622
>sp|Q08881|ITK_HUMAN Tyrosine-protein kinase ITK/TSK OS=Homo sapiens GN=ITK PE=1
SV=1
Length = 620
Score = 173 bits (436), Expect = 4e-042
Identities = 95/267 (35%), Positives = 155/267 (58%), Gaps = 10/267 (3%)
Frame = +3
Query: 87 WEINLQHLKFGHKIASGSYGDLYKGTYCSQE-VAIKVLKPERLDSELEKEFAQEVFIMRK 263
W I+ L F +I SG +G ++ G + +++ VAIK ++ + E++F +E +M K
Sbjct: 356 WVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMS---EEDFIEEAEVMMK 412
Query: 264 VRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNY 443
+ H +VQ G C + +C+V EFM G + DYL Q+G+F LL + +D+C+GM Y
Sbjct: 413 LSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAY 472
Query: 444 LHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGT---YRWMAPEVIE 614
L + +IHRDL A N L+ E++V+KV+DFG+ R T+ TGT +W +PEV
Sbjct: 473 LEEACVIHRDLAARNCLVGENQVIKVSDFGMTRF-VLDDQYTSSTGTKFPVKWASPEVFS 531
Query: 615 HKPYDHKADVFSYGIVLWELLT-GKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMREL 791
Y K+DV+S+G+++WE+ + GKIPYE + + V + G R + + ++
Sbjct: 532 FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSE-VVEDISTGFRLYKPRLASTHVYQI 590
Query: 792 MERLWEKDPTLRPDFSEIIDQLQEISK 872
M W++ P RP FS ++ QL EI++
Sbjct: 591 MNHCWKERPEDRPAFSRLLRQLAEIAE 617
>sp|Q9TTY2|FER_CANFA Tyrosine-protein kinase Fer OS=Canis familiaris GN=FER PE=2
SV=1
Length = 823
Score = 172 bits (435), Expect = 5e-042
Identities = 97/270 (35%), Positives = 156/270 (57%), Gaps = 10/270 (3%)
Frame = +3
Query: 87 WEINLQHLKFGHKIASGSYGDLYKGTYCSQ-EVAIKVLKPERLDSELEKEFAQEVFIMRK 263
W +N + + G + G++G++YKG + VA+K K E L EL+ +F QE I+++
Sbjct: 556 WVLNHEDVTLGELLGKGNFGEVYKGILKDKTAVAVKTCK-EDLPQELKIKFLQEAKILKQ 614
Query: 264 VRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNY 443
H N+V+ IG CT+ + I+ E +PGG +L K+K KL L+K ++D GM+Y
Sbjct: 615 YDHPNIVKLIGVCTQRQPIYIIMELVPGGDFLSFLRKKKDEIKLKQLVKFSLDAASGMSY 674
Query: 444 LHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETG----TYRWMAPEVI 611
L N IHRDL A N L+ E+ V+K++DFG++R + G + + +G +W APE +
Sbjct: 675 LESKNCIHRDLAARNCLVGENNVLKISDFGMSR--QEDGGVYSSSGLKQIPIKWTAPEAL 732
Query: 612 EHKPYDHKADVFSYGIVLWELLT-GKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMRE 788
+ Y ++DV+S+GI+LWE + G PY MT Q A V++G R + + + +
Sbjct: 733 NYGRYSSESDVWSFGILLWETFSLGVCPYPGMTN-QQATEQVERGYRISAPQHCPEDIFK 791
Query: 789 LMERLWEKDPTLRPDFSEIIDQLQEISKEV 878
+M + W+ P RP FSE+ +L I K+V
Sbjct: 792 IMMKCWDYKPENRPKFSELQKELTVIKKKV 821
>sp|P42690|SRK4_SPOLA Tyrosine-protein kinase isoform SRK4 OS=Spongilla
lacustris GN=SRK1 PE=2 SV=1
Length = 506
Score = 170 bits (430), Expect = 2e-041
Identities = 99/271 (36%), Positives = 151/271 (55%), Gaps = 10/271 (3%)
Frame = +3
Query: 87 WEINLQHLKFGHKIASGSYGDLYKGTY-CSQEVAIKVLKPERLDSELEKEFAQEVFIMRK 263
WEI + +K + +G +G++++G + + VA+K LKP + E EF +E IM++
Sbjct: 233 WEIEKKQIKLLRGLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMSIE---EFLEEASIMKQ 289
Query: 264 VRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNY 443
+RH ++Q CTK + IVTE M GS+ +YL KLP L+ + + GM+Y
Sbjct: 290 LRHPKLIQLYAVCTKEEPIYIVTELMKHGSLLEYLRGDGRSLKLPDLVDMCSQVASGMSY 349
Query: 444 LHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGT---YRWMAPEVIE 614
L Q N IHRDL A N+L+ EH++ KVADFG+ARV + A+ G +W APE
Sbjct: 350 LEQQNYIHRDLAARNILVGEHKICKVADFGLARV-IDEEIYEAKLGAKFPIKWTAPEAAM 408
Query: 615 HKPYDHKADVFSYGIVLWELLT-GKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMREL 791
+ + K+DV+S+GIVL+E++T G+ PY MT Q + +Q+ R K+ +
Sbjct: 409 YSRFTIKSDVWSFGIVLYEVITYGRFPYPGMTNAQ-VLEQIQQSYRMPRPMGCPEKLYAI 467
Query: 792 MERLWEKDPTLRPDFSEIIDQLQEISKEVED 884
M W +DP RP F + QL+E +D
Sbjct: 468 MMDCWREDPASRPTFETLSWQLEEFFTTGDD 498
>sp|P09760|FER_RAT Tyrosine-protein kinase Fer (Fragment) OS=Rattus norvegicus
GN=Fer PE=2 SV=1
Length = 323
Score = 169 bits (428), Expect = 3e-041
Identities = 94/270 (34%), Positives = 156/270 (57%), Gaps = 10/270 (3%)
Frame = +3
Query: 87 WEINLQHLKFGHKIASGSYGDLYKGTYCSQ-EVAIKVLKPERLDSELEKEFAQEVFIMRK 263
W +N + + G + G++G++YKGT + VA+K K E L EL+ +F QE I+++
Sbjct: 57 WVLNHEDVSLGELLGKGNFGEVYKGTLKDKTPVAVKTCK-EDLPQELKIKFLQEAKILKQ 115
Query: 264 VRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNY 443
H N+V+ IG CT+ + I+ E +PGG +L K+K KL L++ ++D+ GM Y
Sbjct: 116 YDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLSFLRKRKDELKLKQLVRFSLDVAAGMLY 175
Query: 444 LHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETG----TYRWMAPEVI 611
L N IHRDL A N L+ E+ +K++DFG++R + G + + +G +W APE +
Sbjct: 176 LEGKNCIHRDLAARNCLVGENNTLKISDFGMSR--QEDGGVYSSSGLKQIPIKWTAPEAL 233
Query: 612 EHKPYDHKADVFSYGIVLWELLT-GKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMRE 788
+ Y ++DV+S+GI+LWE + G PY MT QA V++G R + + ++
Sbjct: 234 NYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAR-EQVERGYRMSAPQNCPEEIFT 292
Query: 789 LMERLWEKDPTLRPDFSEIIDQLQEISKEV 878
+M + W+ P RP FS++ +L I K++
Sbjct: 293 IMMKCWDYKPENRPKFSDLHKELTAIKKKI 322
>sp|P42680|TEC_HUMAN Tyrosine-protein kinase Tec OS=Homo sapiens GN=TEC PE=1
SV=2
Length = 631
Score = 169 bits (428), Expect = 3e-041
Identities = 98/272 (36%), Positives = 157/272 (57%), Gaps = 11/272 (4%)
Frame = +3
Query: 87 WEINLQHLKFGHKIASGSYGDLYKGTYCSQ-EVAIKVLKPERLDSELEKEFAQEVFIMRK 263
WEIN L F ++ SG +G + G + +Q +VAIK + R + E++F +E +M K
Sbjct: 363 WEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAI---REGAMCEEDFIEEAKVMMK 419
Query: 264 VRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNY 443
+ H +VQ G CT+ + IVTEFM G + ++L +++G F LL + D+C+GM Y
Sbjct: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEY 479
Query: 444 LHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGTY--RWMAPEVIEH 617
L +N+ IHRDL A N L+ E VVKV+DFG+AR ++ + +W PEV +
Sbjct: 480 LERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNY 539
Query: 618 KPYDHKADVFSYGIVLWELLT-GKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMRELM 794
+ K+DV+S+G+++WE+ T G++P+E T + V +V +G R K + E+M
Sbjct: 540 SRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYE-VVTMVTRGHRLYQPKLASNYVYEVM 598
Query: 795 ERLWEKDPTLRPDFSEIIDQLQEISKEVEDEE 890
R W++ P RP F +++ + E+ VE EE
Sbjct: 599 LRCWQEKPEGRPSFEDLLRTIDEL---VECEE 627
>sp|P24604|TEC_MOUSE Tyrosine-protein kinase Tec OS=Mus musculus GN=Tec PE=1
SV=2
Length = 630
Score = 169 bits (426), Expect = 6e-041
Identities = 98/274 (35%), Positives = 158/274 (57%), Gaps = 11/274 (4%)
Frame = +3
Query: 81 DVWEINLQHLKFGHKIASGSYGDLYKGTYCSQ-EVAIKVLKPERLDSELEKEFAQEVFIM 257
D WEIN L F ++ SG +G + G + +Q +VAIK + R + E++F +E +M
Sbjct: 360 DKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAI---REGAMCEEDFIEEAKVM 416
Query: 258 RKVRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGM 437
K+ H +VQ G CT+ + IVTEFM G + ++L +++G F LL + D+C+GM
Sbjct: 417 MKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDMLLSMCQDVCEGM 476
Query: 438 NYLHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGTY--RWMAPEVI 611
YL +N+ IHRDL A N L++E VVKV+DFG+AR ++ + +W PEV
Sbjct: 477 EYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVF 536
Query: 612 EHKPYDHKADVFSYGIVLWELLT-GKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMRE 788
+ + K+DV+S+G+++WE+ T G++P+E T + V +V +G R K + E
Sbjct: 537 NYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYE-VVTMVTRGHRLHRPKLATKYLYE 595
Query: 789 LMERLWEKDPTLRPDFSEIIDQLQEISKEVEDEE 890
+M R W++ P RP +++ + E+ VE EE
Sbjct: 596 VMLRCWQERPEGRPSLEDLLRTIDEL---VECEE 626
>sp|P70451|FER_MOUSE Tyrosine-protein kinase Fer OS=Mus musculus GN=Fer PE=1
SV=2
Length = 823
Score = 168 bits (423), Expect = 1e-040
Identities = 94/270 (34%), Positives = 155/270 (57%), Gaps = 10/270 (3%)
Frame = +3
Query: 87 WEINLQHLKFGHKIASGSYGDLYKGTYCSQ-EVAIKVLKPERLDSELEKEFAQEVFIMRK 263
W +N + + G + G++G++YKGT + VAIK K E L EL+ +F QE I+++
Sbjct: 557 WVLNHEDVSLGELLGKGNFGEVYKGTLKDKTPVAIKTCK-EDLPQELKIKFLQEAKILKQ 615
Query: 264 VRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNY 443
H N+V+ IG CT+ + I+ E +PGG +L K+K KL L++ ++D+ GM Y
Sbjct: 616 YDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLTFLRKRKDELKLKQLVRFSLDVAAGMLY 675
Query: 444 LHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETG----TYRWMAPEVI 611
L N IHRDL A N L+ E+ +K++DFG++R + G + + +G +W APE +
Sbjct: 676 LESKNCIHRDLAARNCLVGENNTLKISDFGMSR--QEDGGVYSSSGLKQIPIKWTAPEAL 733
Query: 612 EHKPYDHKADVFSYGIVLWELLT-GKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMRE 788
+ Y ++DV+S+GI+LWE + G PY MT QA V++G R + + ++
Sbjct: 734 NYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAR-EQVERGYRMSAPQNCPEEVFT 792
Query: 789 LMERLWEKDPTLRPDFSEIIDQLQEISKEV 878
+M + W+ P RP F+++ +L I K +
Sbjct: 793 IMMKCWDYKPENRPKFNDLHKELTVIKKMI 822
>sp|P42682|TXK_MOUSE Tyrosine-protein kinase TXK OS=Mus musculus GN=Txk PE=1
SV=1
Length = 527
Score = 165 bits (417), Expect = 7e-040
Identities = 97/268 (36%), Positives = 150/268 (55%), Gaps = 12/268 (4%)
Frame = +3
Query: 87 WEINLQHLKFGHKIASGSYGDLYKGTYCSQ-EVAIKVLKPERLDSELEKEFAQEVFIMRK 263
WEI+ L F +I SG +G ++ G + + VAIK + S E++F +E +M K
Sbjct: 264 WEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAINE---GSMSEEDFIEEAKVMMK 320
Query: 264 VRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNY 443
+ H +VQ G C + L IVTEFM G + DYL ++KG + LL + DIC+GM Y
Sbjct: 321 LSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMCQDICEGMAY 380
Query: 444 LHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGTY--RWMAPEVIEH 617
L ++ IHRDL A N L+ VVK++DFG+AR +++ + +W PEV
Sbjct: 381 LERSCYIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHF 440
Query: 618 KPYDHKADVFSYGIVLWELLT-GKIPYEYMTPLQAAVGVVQ--KGLRPTIAKKTHPKMRE 788
Y K+DV+S+G+++WE+ T GK+P+E + LQ + Q + RP +A T +
Sbjct: 441 NKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISQGFRLYRPHLAPMT---IYR 497
Query: 789 LMERLWEKDPTLRPDFSEIIDQLQEISK 872
+M W + P RP F+E++ L EI++
Sbjct: 498 VMYSCWHESPKGRPTFAELLQVLTEIAE 525
>sp|P42681|TXK_HUMAN Tyrosine-protein kinase TXK OS=Homo sapiens GN=TXK PE=1
SV=3
Length = 527
Score = 164 bits (414), Expect = 1e-039
Identities = 95/266 (35%), Positives = 147/266 (55%), Gaps = 8/266 (3%)
Frame = +3
Query: 87 WEINLQHLKFGHKIASGSYGDLYKGTYCSQ-EVAIKVLKPERLDSELEKEFAQEVFIMRK 263
WEI+ L F +I SG +G ++ G + S +VAIK + S E++F +E +M K
Sbjct: 264 WEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINE---GSMSEEDFIEEAKVMMK 320
Query: 264 VRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNY 443
+ H +VQ G C + L IVTEFM G + +YL + KG + LL V DIC+GM Y
Sbjct: 321 LSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEY 380
Query: 444 LHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGTY--RWMAPEVIEH 617
L +N IHRDL A N L+ +VK++DFG+ R +++ + +W PEV
Sbjct: 381 LERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLF 440
Query: 618 KPYDHKADVFSYGIVLWELLT-GKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMRELM 794
Y K+DV+S+G+++WE+ T GK+P+E + LQ V + +G R + E+M
Sbjct: 441 NKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQ-VVEAISEGFRLYRPHLAPMSIYEVM 499
Query: 795 ERLWEKDPTLRPDFSEIIDQLQEISK 872
W + P RP F+E++ + EI++
Sbjct: 500 YSCWHEKPEGRPTFAELLRAVTEIAE 525
>sp|P42688|SRK2_SPOLA Tyrosine-protein kinase SRK2 (Fragment) OS=Spongilla
lacustris GN=SRK2 PE=2 SV=1
Length = 362
Score = 160 bits (403), Expect = 3e-038
Identities = 91/265 (34%), Positives = 146/265 (55%), Gaps = 8/265 (3%)
Frame = +3
Query: 81 DVWEINLQHLKFGHKIASGSYGDLYKGTY-CSQEVAIKVLKPERLDSELEKEFAQEVFIM 257
D+WEI+ + K+ +G +G++Y+G + S VA+K LK + F E IM
Sbjct: 86 DMWEISRDSITLIRKLGAGQFGEVYQGLWNNSTPVAVKTLKAGTMQ---PAAFLAEAQIM 142
Query: 258 RKVRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGM 437
+K+RH ++Q CT+ + I+TE M GS+ DYL + G KLP L+ +A + GM
Sbjct: 143 KKLRHPKLIQLYAVCTQGEPVYIITELMSKGSLLDYLQGEAGALKLPQLIDMAAQVAAGM 202
Query: 438 NYLHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGTY--RWMAPEVI 611
YL +N IHRDL A N+L+ ++ + KVADFG+AR+ E + +W APE
Sbjct: 203 AYLELHNYIHRDLAARNILVGDNNICKVADFGLARLIVSDDYNATEGAKFPIKWTAPEAA 262
Query: 612 EHKPYDHKADVFSYGIVLWELLT-GKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMRE 788
+ K+DV+S+GI++ EL+T G+IPY M+ + + KG R T + +
Sbjct: 263 LFNRFSIKSDVWSFGILITELVTYGRIPYPGMSNAEVLQN-LDKGYRMPCPVTTPESLYQ 321
Query: 789 LMERLWEKDPTLRPDFSEIIDQLQE 863
+M W+++P RP F + +L++
Sbjct: 322 IMLDCWKRNPADRPTFEALQWRLED 346
>sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kinase 12 OS=Rattus
norvegicus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 156 bits (394), Expect = 3e-037
Identities = 81/215 (37%), Positives = 123/215 (57%), Gaps = 3/215 (1%)
Frame = +3
Query: 255 MRKVRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALL-KVAIDICK 431
+RK++H N++ F G CT+ P CI+ EF G +Y+ L + V P+LL ++ I
Sbjct: 198 LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPV--TPSLLVDWSMGIAG 255
Query: 432 GMNYLHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGTYRWMAPEVI 611
GMNYLH + IIHRDLK+ N+L+ +VVK++DFG ++ + + GT WMAPEVI
Sbjct: 256 GMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI 315
Query: 612 EHKPYDHKADVFSYGIVLWELLTGKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMREL 791
++P K D++S+G+VLWELLTG+IPY+ + GV L + + L
Sbjct: 316 RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKIL 375
Query: 792 MERLWEKDPTLRPDFSEIIDQLQEISKEVEDEEEE 896
+ + W + P RP F +I+ L S +V +E
Sbjct: 376 LRQCWNRKPRNRPSFRQILLHLDIASADVLSTPQE 410
>sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 OS=Homo
sapiens GN=MAP3K12 PE=1 SV=2
Length = 859
Score = 156 bits (392), Expect = 5e-037
Identities = 81/215 (37%), Positives = 122/215 (56%), Gaps = 3/215 (1%)
Frame = +3
Query: 255 MRKVRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALL-KVAIDICK 431
+RK++H N++ F G CT+ P CI+ EF G +Y+ L + V P+LL ++ I
Sbjct: 165 LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPV--TPSLLVDWSMGIAG 222
Query: 432 GMNYLHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGTYRWMAPEVI 611
GMNYLH + IIHRDLK+ N+L+ +VVK++DFG ++ + + GT WMAPEVI
Sbjct: 223 GMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI 282
Query: 612 EHKPYDHKADVFSYGIVLWELLTGKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMREL 791
++P K D++S+G+VLWELLTG+IPY+ + GV L + + L
Sbjct: 283 RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKIL 342
Query: 792 MERLWEKDPTLRPDFSEIIDQLQEISKEVEDEEEE 896
+ + W P RP F +I+ L S +V +E
Sbjct: 343 LRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQE 377
>sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase kinase 12 OS=Mus
musculus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 156 bits (392), Expect = 5e-037
Identities = 81/215 (37%), Positives = 122/215 (56%), Gaps = 3/215 (1%)
Frame = +3
Query: 255 MRKVRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALL-KVAIDICK 431
+RK++H N++ F G CT+ P CI+ EF G +Y+ L + V P+LL ++ I
Sbjct: 198 LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPV--TPSLLVDWSMGIAG 255
Query: 432 GMNYLHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGTYRWMAPEVI 611
GMNYLH + IIHRDLK+ N+L+ +VVK++DFG ++ + + GT WMAPEVI
Sbjct: 256 GMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI 315
Query: 612 EHKPYDHKADVFSYGIVLWELLTGKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMREL 791
++P K D++S+G+VLWELLTG+IPY+ + GV L + + L
Sbjct: 316 RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKIL 375
Query: 792 MERLWEKDPTLRPDFSEIIDQLQEISKEVEDEEEE 896
+ + W P RP F +I+ L S +V +E
Sbjct: 376 LRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQE 410
>sp|A7J1T0|M313B_XENLA Mitogen-activated protein kinase kinase kinase 13-B
OS=Xenopus laevis GN=map3k13-b PE=2 SV=1
Length = 961
Score = 153 bits (384), Expect = 4e-036
Identities = 76/214 (35%), Positives = 121/214 (56%), Gaps = 1/214 (0%)
Frame = +3
Query: 255 MRKVRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKG 434
+RK++H N++ F G CT+ P CI+ E+ G +Y+ L + V L++ + I G
Sbjct: 211 LRKLKHPNIIAFKGVCTQAPCYCILMEYCAQGQLYEVLRAGRKVTP-KLLVEWSTGIASG 269
Query: 435 MNYLHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGTYRWMAPEVIE 614
MNYLH + IIHRDLK+ N+L+ + VK++DFG ++ + + GT WMAPEVI
Sbjct: 270 MNYLHLHKIIHRDLKSPNVLVTHADTVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIR 329
Query: 615 HKPYDHKADVFSYGIVLWELLTGKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMRELM 794
++P K D++S+G++LWELLTG+IPY+ + GV L + + LM
Sbjct: 330 NEPVSEKVDIWSFGVLLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILM 389
Query: 795 ERLWEKDPTLRPDFSEIIDQLQEISKEVEDEEEE 896
++ W+ P RP F +I+ L + +V +E
Sbjct: 390 KQTWQSKPRNRPSFRQILMHLDIAAADVLGTPQE 423
>sp|O43283|M3K13_HUMAN Mitogen-activated protein kinase kinase kinase 13 OS=Homo
sapiens GN=MAP3K13 PE=1 SV=1
Length = 966
Score = 152 bits (383), Expect = 6e-036
Identities = 77/209 (36%), Positives = 118/209 (56%), Gaps = 3/209 (1%)
Frame = +3
Query: 255 MRKVRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPALL-KVAIDICK 431
+RK++H N++ F G CT+ P CI+ E+ G +Y+ L + + P LL + I
Sbjct: 208 LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKI--TPRLLVDWSTGIAS 265
Query: 432 GMNYLHQNNIIHRDLKAANLLMDEHEVVKVADFGVARVKAQTGVMTAETGTYRWMAPEVI 611
GMNYLH + IIHRDLK+ N+L+ + VK++DFG ++ + + GT WMAPEVI
Sbjct: 266 GMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI 325
Query: 612 EHKPYDHKADVFSYGIVLWELLTGKIPYEYMTPLQAAVGVVQKGLRPTIAKKTHPKMREL 791
++P K D++S+G+VLWELLTG+IPY+ + GV L + + L
Sbjct: 326 RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKIL 385
Query: 792 MERLWEKDPTLRPDFSEIIDQLQEISKEV 878
M++ W+ P RP F + + L S +V
Sbjct: 386 MKQTWQSKPRNRPSFRQTLMHLDIASADV 414
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,759,707,213
Number of Sequences: 518415
Number of Extensions: 54759707213
Number of Successful Extensions: 366332288
Number of sequences better than 0.0: 0
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