BLASTX 7.6.2
Query= UN13735 /QuerySize=968
(967 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54QP6|OSB8_DICDI Oxysterol-binding protein 8 OS=Dictyosteliu... 77 1e-013
sp|Q8K4M9|OSBL1_RAT Oxysterol-binding protein-related protein 1 ... 71 9e-012
sp|Q9BXW6|OSBL1_HUMAN Oxysterol-binding protein-related protein ... 71 1e-011
sp|Q91XL9|OSBL1_MOUSE Oxysterol-binding protein-related protein ... 71 1e-011
sp|P35845|OSH1_YEAST Oxysterol-binding protein homolog 1 OS=Sacc... 68 8e-011
sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2 OS=Sacc... 67 2e-010
sp|O13944|YEH1_SCHPO Oxysterol-binding protein homolog C23H4.01c... 66 4e-010
sp|Q9H1P3|OSBL2_HUMAN Oxysterol-binding protein-related protein ... 65 8e-010
sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c... 64 1e-009
sp|P38713|OSH3_YEAST Oxysterol-binding protein homolog 3 OS=Sacc... 62 7e-009
sp|Q8BX94|OSBL2_MOUSE Oxysterol-binding protein-related protein ... 61 9e-009
sp|Q9BZF2|OSBL7_HUMAN Oxysterol-binding protein-related protein ... 59 6e-008
sp|Q969R2|OSBP2_HUMAN Oxysterol-binding protein 2 OS=Homo sapien... 54 2e-006
>sp|Q54QP6|OSB8_DICDI Oxysterol-binding protein 8 OS=Dictyostelium discoideum
GN=osbH PE=1 SV=1
Length = 402
Score = 77 bits (189), Expect = 1e-013
Identities = 54/169 (31%), Positives = 89/169 (52%), Gaps = 13/169 (7%)
Frame = +2
Query: 227 SGRYEVDGYVYNASEEPKILMTGKWNESMSYQQCDGEGEPLPGTELKEVWKLADVPKDDK 406
+GRY V G + + + + +TGKWNES+ Q G T +W+ + P ++K
Sbjct: 239 AGRYGVTGEIVDCEGDVRYRITGKWNESIQLFQVMDNGS--SSTTSTCLWEASKEPINNK 296
Query: 407 YQYTHFAHK-INSFDTAPKKLLP-SDSRLRPDRYALEMGDMSKSGNEKSSLEERQRAEKR 580
+ + + + + + KK+LP +DSRLR DR ALE G++ + EK +LEE+QR +KR
Sbjct: 297 FLFPRWVEENVIDLNDEYKKILPVTDSRLRADRIALEEGNLDVAAKEKHNLEEKQREDKR 356
Query: 581 TRQEKEQSFTPKWFDITEEVTPTPWGDLEVYQFN--GKYLEHREAADKS 721
R + + + F ++V +G Y++N G Y E RE K+
Sbjct: 357 QRVAENKEWETAQF---KKVDDAKFG----YRWNYCGNYWEEREERVKA 398
>sp|Q8K4M9|OSBL1_RAT Oxysterol-binding protein-related protein 1 OS=Rattus
norvegicus GN=Osbpl1a PE=1 SV=1
Length = 950
Score = 71 bits (173), Expect = 9e-012
Identities = 38/118 (32%), Positives = 67/118 (56%), Gaps = 9/118 (7%)
Frame = +2
Query: 347 LPGTELKEVWKLADVPKD--DKYQYTHFAHKINSFDTAPKKLLP-SDSRLRPDRYALEMG 517
+PG+ L +W++A P + Y +T FA +N D + ++P +D RLRPD A+E G
Sbjct: 827 IPGSAL--LWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMETVIPKTDCRLRPDIRAMENG 884
Query: 518 DMSKSGNEKSSLEERQRAEKRTRQEKEQSFTPKWFDITEEVTPTPWGDLEVYQFNGKY 691
++ ++ EK LEE+QRA ++ R + E+ + +WF P P+ + + ++G Y
Sbjct: 885 EIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWF----HQGPNPYSGAQDWIYSGSY 938
>sp|Q9BXW6|OSBL1_HUMAN Oxysterol-binding protein-related protein 1 OS=Homo
sapiens GN=OSBPL1A PE=1 SV=2
Length = 950
Score = 71 bits (172), Expect = 1e-011
Identities = 38/118 (32%), Positives = 67/118 (56%), Gaps = 9/118 (7%)
Frame = +2
Query: 347 LPGTELKEVWKLADVPKD--DKYQYTHFAHKINSFDTAPKKLLP-SDSRLRPDRYALEMG 517
+PG+ L +W++A P + Y +T FA +N D + ++P +D RLRPD A+E G
Sbjct: 827 IPGSVL--LWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENG 884
Query: 518 DMSKSGNEKSSLEERQRAEKRTRQEKEQSFTPKWFDITEEVTPTPWGDLEVYQFNGKY 691
++ ++ EK LEE+QRA ++ R + E+ + +WF P P+ + + ++G Y
Sbjct: 885 EIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWF----HQGPNPYNGAQDWIYSGSY 938
>sp|Q91XL9|OSBL1_MOUSE Oxysterol-binding protein-related protein 1 OS=Mus
musculus GN=Osbpl1a PE=1 SV=2
Length = 950
Score = 71 bits (172), Expect = 1e-011
Identities = 45/148 (30%), Positives = 74/148 (50%), Gaps = 10/148 (6%)
Frame = +2
Query: 260 NASEEPKILMTGKWNESMSYQQCDGEGE-PLPGTELKEVWKLADVPKD--DKYQYTHFAH 430
N E+ T ES D E +PG+ L +W++A P + Y +T FA
Sbjct: 797 NTEEKKNSKQTSSSEESDEMPVPDSESVFIIPGSVL--LWRIAPRPPNSAQMYNFTSFAM 854
Query: 431 KINSFDTAPKKLLP-SDSRLRPDRYALEMGDMSKSGNEKSSLEERQRAEKRTRQEKEQSF 607
+N D + ++P +D RLRPD A+E G++ + EK LEE+QRA ++ R + E+ +
Sbjct: 855 VLNEVDKEMESVIPKTDCRLRPDIRAMENGEIDLASEEKKRLEEKQRAARKNRSKSEEDW 914
Query: 608 TPKWFDITEEVTPTPWGDLEVYQFNGKY 691
+WF P P+ + + ++G Y
Sbjct: 915 KTRWF----HQGPNPYSGAQDWIYSGSY 938
>sp|P35845|OSH1_YEAST Oxysterol-binding protein homolog 1 OS=Saccharomyces
cerevisiae GN=OSH1 PE=1 SV=4
Length = 1188
Score = 68 bits (165), Expect = 8e-011
Identities = 45/127 (35%), Positives = 69/127 (54%), Gaps = 7/127 (5%)
Frame = +2
Query: 338 GEPLPGTELKEVWKLADVPKDDKYQYTHFAHKINSFDT-APKKLLPSDSRLRPDRYALEM 514
G L G++ +WK + P + T FA +N+ L P+DSRLRPD+ A+E
Sbjct: 1060 GPKLDGSKFL-IWKANERP-SVPFNLTSFALTLNALPPHLIPYLAPTDSRLRPDQRAMEN 1117
Query: 515 GDMSKSGNEKSSLEERQRAEKRTRQEKEQSFTPKWFDITEEVTPTPWGDLEVYQFNGKYL 694
G+ K+ EK +E +QRA K+ R++K + + PKWF + EE P ++FNG+Y
Sbjct: 1118 GEYDKAAAEKHRVEVKQRAAKKEREQKGEEYRPKWF-VQEE---HPVTKSLYWKFNGEYW 1173
Query: 695 EHREAAD 715
R+ D
Sbjct: 1174 NKRKNHD 1180
>sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2 OS=Saccharomyces
cerevisiae GN=OSH2 PE=1 SV=1
Length = 1283
Score = 67 bits (161), Expect = 2e-010
Identities = 47/134 (35%), Positives = 71/134 (52%), Gaps = 17/134 (12%)
Frame = +2
Query: 332 GEGEPLPGTELKEVWKLADVPKDDKYQYTHFAHKINSFDTAPKK-----LLPSDSRLRPD 496
G G GT+ +WK D P ++ + T FA +N AP+ L P+D+RLRPD
Sbjct: 1153 GNGPTDDGTKFL-IWKANDRP-EEPFNLTPFAITLN----APQPHLLPWLPPTDTRLRPD 1206
Query: 497 RYALEMGDMSKSGNEKSSLEERQRAEKRTRQEKEQSFTPKWFDITEEVTPT-PWGDLEVY 673
+ A+E G ++G+EK +EE+QRA +R R+E + P+WF V T P + +
Sbjct: 1207 QRAMEDGRYDEAGDEKFRVEEKQRAARRKREENNLEYHPQWF-----VRDTHPITKAKYW 1261
Query: 674 QFNGKYLEHREAAD 715
++ GKY R D
Sbjct: 1262 RYTGKYWVKRRDHD 1275
>sp|O13944|YEH1_SCHPO Oxysterol-binding protein homolog C23H4.01c
OS=Schizosaccharomyces pombe GN=SPAC23H4.01c PE=1 SV=2
Length = 945
Score = 66 bits (159), Expect = 4e-010
Identities = 43/122 (35%), Positives = 64/122 (52%), Gaps = 6/122 (4%)
Frame = +2
Query: 260 NASEEPKILMTGKWNESMSYQQCDGEGEPLPGTELKEVWKLADVPKDDKYQYTHFAHKIN 439
N E+PK L GKW + + D EG + + EV L D P +D T FA ++N
Sbjct: 787 NGEEDPKCLQ-GKWTSHLDFVNTD-EGNVI--ERIWEVGPLVDKP-EDHCGMTVFAAQMN 841
Query: 440 SF-DTAPKKLLPSDSRLRPDRYALEMGDMSKSGNEKSSLEERQRAEKRTRQEKEQSFTPK 616
D KL P+D+RLRPD+ E D+ + K LE++QR ++ +EK+ + P+
Sbjct: 842 EITDLEKDKLPPTDTRLRPDQRYRENNDLDHAEPLKLELEQKQRERRKEMEEKDIKWEPR 901
Query: 617 WF 622
WF
Sbjct: 902 WF 903
>sp|Q9H1P3|OSBL2_HUMAN Oxysterol-binding protein-related protein 2 OS=Homo
sapiens GN=OSBPL2 PE=1 SV=1
Length = 480
Score = 65 bits (156), Expect = 8e-010
Identities = 34/95 (35%), Positives = 55/95 (57%), Gaps = 5/95 (5%)
Frame = +2
Query: 347 LPGTELKEVWKLADVPKD--DKYQYTHFAHKINSFDTAPKKLL-PSDSRLRPDRYALEMG 517
+PG++L +W++ P + Y +T F +N +T +K L P+D RLRPD +E G
Sbjct: 357 IPGSKL--LWRINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENG 414
Query: 518 DMSKSGNEKSSLEERQRAEKRTRQEKEQSFTPKWF 622
+M + EK LEE+QR +R R ++E + +WF
Sbjct: 415 NMDLASQEKERLEEKQREARRERAKEEAEWQTRWF 449
>sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c
OS=Schizosaccharomyces pombe GN=SPBC2F12.05c PE=1 SV=2
Length = 1310
Score = 64 bits (154), Expect = 1e-009
Identities = 37/107 (34%), Positives = 62/107 (57%), Gaps = 6/107 (5%)
Frame = +2
Query: 407 YQYTHFAHKINSFDTAPKKLL-PSDSRLRPDRYALEMGDMSKSGNEKSSLEERQRAEKRT 583
+ T FA +N+ K L P+D+RLRPD+ A+E G + +EK+ LEE+QR ++R
Sbjct: 1192 FNLTPFAISLNALTPQLKPWLPPTDTRLRPDQRAMENGQYDLAASEKNRLEEKQRKKRRM 1251
Query: 584 RQEKEQ-SFTPKWFDITEEVTPTPWGDLEVYQFNGKYLEHREAADKS 721
R++ E ++P+WF + P + +QFN +Y + RE A ++
Sbjct: 1252 REQGEMPPWSPRWFSAAKH----PVTGEDYWQFNNEYWKIREEAGEA 1294
>sp|P38713|OSH3_YEAST Oxysterol-binding protein homolog 3 OS=Saccharomyces
cerevisiae GN=OSH3 PE=1 SV=1
Length = 996
Score = 62 bits (148), Expect = 7e-009
Identities = 48/151 (31%), Positives = 72/151 (47%), Gaps = 23/151 (15%)
Frame = +2
Query: 215 FFNRSGRYEVDGYVYNASEEPKILMTGKWNESMSYQQCDGEGEPLPGTELKEVWKLADV- 391
F RS ++V +S K + GKW +S++ + T + +W++ D+
Sbjct: 840 FSGRSEGFKVSIIPPPSSNRKKETLAGKWTQSLANE-----------TTHETIWEVGDLV 888
Query: 392 --PKDDKYQYTHFAHKINSFDTAPK-KLLPSDSRLRPDRYALEMGDMSKSGNEKSSLEER 562
PK KY +T F +N K L P+DSRLRPD A E G++ K+ K LE+
Sbjct: 889 SNPK-KKYGFTKFTANLNEITEIEKGNLPPTDSRLRPDIRAYEEGNVDKAEEWKLKLEQL 947
Query: 563 QRAEKRTRQEKEQSFTPKWFDITEEVTPTPW 655
Q R R+ K Q PK+F E+V+ W
Sbjct: 948 Q----RERRNKGQDVEPKYF---EKVSKNEW 971
>sp|Q8BX94|OSBL2_MOUSE Oxysterol-binding protein-related protein 2 OS=Mus
musculus GN=Osbpl2 PE=2 SV=1
Length = 484
Score = 61 bits (147), Expect = 9e-009
Identities = 31/95 (32%), Positives = 55/95 (57%), Gaps = 5/95 (5%)
Frame = +2
Query: 347 LPGTELKEVWKLADVPKD--DKYQYTHFAHKINSFDTAPKKLL-PSDSRLRPDRYALEMG 517
+PG++L +W++ P + Y +T F +N ++ +K L P+D RLRPD +E G
Sbjct: 361 IPGSKL--LWRINSRPPNSAQMYNFTSFTVSLNELESGMEKTLPPTDCRLRPDIRGMENG 418
Query: 518 DMSKSGNEKSSLEERQRAEKRTRQEKEQSFTPKWF 622
+M + EK LEE+QR ++ R +++ + +WF
Sbjct: 419 NMDLASQEKERLEEKQREARKERAKEDAEWRTRWF 453
>sp|Q9BZF2|OSBL7_HUMAN Oxysterol-binding protein-related protein 7 OS=Homo
sapiens GN=OSBPL7 PE=2 SV=1
Length = 842
Score = 59 bits (140), Expect = 6e-008
Identities = 42/146 (28%), Positives = 72/146 (49%), Gaps = 12/146 (8%)
Frame = +2
Query: 227 SGRYEVDGYVYNASEEPKILMTGKWNESMSYQQCDGEGEPLPGTELKEVWKLADVPKDDK 406
S +EV G V + S + GKW+E + Y+ P PG + +WK +P D +
Sbjct: 681 SNVHEVQGAVLSRSGRVLHRLFGKWHEGL-YR------GPTPGGQC--IWKPNSMPPDHE 731
Query: 407 --YQYTHFAHKINSFDTAPKKLLPS-DSRLRPDRYALEMGDMSKSGNEKSSLEERQRAEK 577
+ +T FA ++N K+ LPS D+RLRPD+ LE G++ + +K +E+ QR +
Sbjct: 732 RNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRR 791
Query: 578 RTRQEKEQSFTPKWFDITEEVTPTPW 655
+ +E ++F + + W
Sbjct: 792 KVMEENNIVHQARFFRRQTDSSGKEW 817
>sp|Q969R2|OSBP2_HUMAN Oxysterol-binding protein 2 OS=Homo sapiens GN=OSBP2 PE=1
SV=2
Length = 916
Score = 54 bits (127), Expect = 2e-006
Identities = 34/115 (29%), Positives = 61/115 (53%), Gaps = 2/115 (1%)
Frame = +2
Query: 251 YVYNASEEPKILMTGKWNESMSYQQCDGEGEPLPGT-ELKEVWKLADVPKDDKYQYTHFA 427
YV + S + ++ + + S S DG+ + + T K +WK +P++ + Y +F+
Sbjct: 744 YVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMY-YFS 802
Query: 428 HKINSFDTAPKKLLPSDSRLRPDRYALEMGDMSKSGNEKSSLEERQRAEKRTRQE 592
+ + + + P+DSRLRPD+ +E G ++ EK LEE+QR +R R E
Sbjct: 803 ELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLE 857
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,281,224,270
Number of Sequences: 518415
Number of Extensions: 55281224270
Number of Successful Extensions: 373770181
Number of sequences better than 0.0: 0
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