BLASTX 7.6.2
Query= UN13787 /QuerySize=1285
(1284 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q84JL3|SINA3_ARATH E3 ubiquitin-protein ligase SINAT3 OS=Arab... 660 9e-189
sp|Q9STN8|SINA4_ARATH E3 ubiquitin-protein ligase SINAT4 OS=Arab... 525 3e-148
sp|Q8S3N1|SINA5_ARATH E3 ubiquitin-protein ligase SINAT5 OS=Arab... 523 1e-147
sp|Q9M2P4|SINA2_ARATH E3 ubiquitin-protein ligase SINAT2 OS=Arab... 467 1e-130
sp|P93748|SINA1_ARATH Putative E3 ubiquitin-protein ligase SINAT... 460 2e-128
sp|Q86MW9|SINA_SCHMA E3 ubiquitin-protein ligase sina OS=Schisto... 169 4e-041
sp|Q7ZVG6|SIAH1_DANRE E3 ubiquitin-protein ligase Siah1 OS=Danio... 163 3e-039
sp|P61092|SIA1A_MOUSE E3 ubiquitin-protein ligase SIAH1A OS=Mus ... 163 3e-039
sp|Q920M9|SIAH1_RAT E3 ubiquitin-protein ligase SIAH1 OS=Rattus ... 163 3e-039
sp|Q8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 OS=Homo ... 162 6e-039
sp|Q06985|SIA1B_MOUSE E3 ubiquitin-protein ligase SIAH1B OS=Mus ... 159 4e-038
sp|P61093|SINA_DROER E3 ubiquitin-protein ligase sina OS=Drosoph... 156 5e-037
sp|P21461|SINA_DROME E3 ubiquitin-protein ligase sina OS=Drosoph... 156 5e-037
sp|Q8I147|SINA_DROWI E3 ubiquitin-protein ligase sina OS=Drosoph... 156 5e-037
sp|P29304|SINA_DROVI E3 ubiquitin-protein ligase sina OS=Drosoph... 154 2e-036
sp|Q8T3Y0|SINAL_DROME Probable E3 ubiquitin-protein ligase sinah... 150 3e-035
sp|Q7SYL3|SIAH2_DANRE E3 ubiquitin-protein ligase Siah2 OS=Danio... 149 4e-035
sp|Q06986|SIAH2_MOUSE E3 ubiquitin-protein ligase SIAH2 OS=Mus m... 148 1e-034
sp|Q8R4T2|SIAH2_RAT E3 ubiquitin-protein ligase SIAH2 OS=Rattus ... 148 1e-034
sp|O43255|SIAH2_HUMAN E3 ubiquitin-protein ligase SIAH2 OS=Homo ... 146 4e-034
>sp|Q84JL3|SINA3_ARATH E3 ubiquitin-protein ligase SINAT3 OS=Arabidopsis
thaliana GN=SINAT3 PE=2 SV=1
Length = 326
Score = 660 bits (1701), Expect = 9e-189
Identities = 312/328 (95%), Positives = 318/328 (96%), Gaps = 5/328 (1%)
Frame = +1
Query: 97 MDLDSMDCASTVDITDDEEIHQDRHSYASVSKHH---SNNSNANAAASGLLPTTTSVHEL 267
MDLDSMDC ST+D+TDDEEIHQDRHSYASVSKHH +N +N NAAASGLLPTTTSVHEL
Sbjct: 1 MDLDSMDCTSTMDVTDDEEIHQDRHSYASVSKHHHTNNNTTNVNAAASGLLPTTTSVHEL 60
Query: 268 LECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNRCPTCRQELGDIRCLALEKVAESLELP 447
LECPVCTNSMYPPIHQCHNGHTLCSTCK RVHNRCPTCRQELGDIRCLALEKVAESLELP
Sbjct: 61 LECPVCTNSMYPPIHQCHNGHTLCSTCKARVHNRCPTCRQELGDIRCLALEKVAESLELP 120
Query: 448 CKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYAGSECSVMGDIPFLVAHLRDDHKVDMH 627
CK+MSLGCPEIFPYYSKLKHETVCNFRPY+CPYAGSECSV GDIPFLVAHLRDDHKVDMH
Sbjct: 121 CKHMSLGCPEIFPYYSKLKHETVCNFRPYSCPYAGSECSVTGDIPFLVAHLRDDHKVDMH 180
Query: 628 SGCTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMAPVYMAFLRFMGDET 807
SGCTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMAPVYMAFLRFMGDET
Sbjct: 181 SGCTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMAPVYMAFLRFMGDET 240
Query: 808 EARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDGLIIQRNMALFFSGGDRKELK 987
EARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDGLIIQRNMALFFSGGDRKELK
Sbjct: 241 EARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDGLIIQRNMALFFSGGDRKELK 300
Query: 988 LRVTGRIWKEQQQQSGEGGGGACIPNLS 1071
LRVTGRIWKE QQQSGE GGGACIPNLS
Sbjct: 301 LRVTGRIWKE-QQQSGE-GGGACIPNLS 326
>sp|Q9STN8|SINA4_ARATH E3 ubiquitin-protein ligase SINAT4 OS=Arabidopsis
thaliana GN=SINAT4 PE=2 SV=1
Length = 327
Score = 525 bits (1351), Expect = 3e-148
Identities = 254/330 (76%), Positives = 278/330 (84%), Gaps = 14/330 (4%)
Frame = +1
Query: 97 MDLDSMDCASTV--DITDDEEIHQDRHSYA-SVSKHHSNNSNANAAASGLLPT----TTS 255
M+ DSM+C S+ +I + HQ SY S +K H + A + + PT TS
Sbjct: 1 METDSMECVSSTGNEIHQNGNGHQ---SYQFSSTKTHGGAAAAAVVTNIVGPTATAPATS 57
Query: 256 VHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNRCPTCRQELGDIRCLALEKVAES 435
V+ELLECPVCT SMYPPIHQCHNGHTLCSTCK RVHNRCPTCRQELGDIRCLALEKVAES
Sbjct: 58 VYELLECPVCTYSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAES 117
Query: 436 LELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYAGSECSVMGDIPFLVAHLRDDHK 615
LELPCK+ +LGCPEIFPYYSKLKHE++CNFRPY+CPYAGSEC ++GDIPFLVAHLRDDHK
Sbjct: 118 LELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYSCPYAGSECGIVGDIPFLVAHLRDDHK 177
Query: 616 VDMHSGCTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMAPVYMAFLRFM 795
VDMH+G TFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGM PVYMAFLRFM
Sbjct: 178 VDMHAGSTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMGPVYMAFLRFM 237
Query: 796 GDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDGLIIQRNMALFFSGGDR 975
GDE +AR+Y+YSLEVGG GRKL WEGTPRS+RDSHRKVRDS+DGLIIQRNMALFFSGGDR
Sbjct: 238 GDEEDARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDR 297
Query: 976 KELKLRVTGRIWKEQQQQSGEGGGGACIPN 1065
KELKLRVTG+IWKEQ G IPN
Sbjct: 298 KELKLRVTGKIWKEQHSPD----SGLSIPN 323
>sp|Q8S3N1|SINA5_ARATH E3 ubiquitin-protein ligase SINAT5 OS=Arabidopsis
thaliana GN=SINAT5 PE=1 SV=2
Length = 309
Score = 523 bits (1346), Expect = 1e-147
Identities = 242/290 (83%), Positives = 259/290 (89%), Gaps = 4/290 (1%)
Frame = +1
Query: 190 KHHSNNSNANAAASGLLPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNR 369
KH +++ + A+ ++ TSV+ELLECPVCTNSMYPPIHQCHNGHTLCSTCK+RVHNR
Sbjct: 18 KHQFSSTKSQGGATVVISPATSVYELLECPVCTNSMYPPIHQCHNGHTLCSTCKSRVHNR 77
Query: 370 CPTCRQELGDIRCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYA 549
CPTCRQELGDIRCLALEKVAESLELPCKY +LGC IFPYYSKLKHE+ CNFRPY+CPYA
Sbjct: 78 CPTCRQELGDIRCLALEKVAESLELPCKYYNLGCLGIFPYYSKLKHESQCNFRPYSCPYA 137
Query: 550 GSECSVMGDIPFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVENATWMLTVFHCFGQYF 729
GSEC+ +GDI FLVAHLRDDHKVDMH+GCTFNHRYVKSNPREVENATWMLTVF CFGQYF
Sbjct: 138 GSECAAVGDITFLVAHLRDDHKVDMHTGCTFNHRYVKSNPREVENATWMLTVFQCFGQYF 197
Query: 730 CLHFEAFQLGMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKV 909
CLHFEAFQLGMAPVYMAFLRFMGDE +ARNY YSLEVGG GRK WEGTPRSVRDSHRKV
Sbjct: 198 CLHFEAFQLGMAPVYMAFLRFMGDEDDARNYTYSLEVGGSGRKQTWEGTPRSVRDSHRKV 257
Query: 910 RDSHDGLIIQRNMALFFSGGDRKELKLRVTGRIWKEQQQQSGEGGGGACI 1059
RDSHDGLIIQRNMALFFSGGD+KELKLRVTGRIWKEQQ G CI
Sbjct: 258 RDSHDGLIIQRNMALFFSGGDKKELKLRVTGRIWKEQQNPD----SGVCI 303
>sp|Q9M2P4|SINA2_ARATH E3 ubiquitin-protein ligase SINAT2 OS=Arabidopsis
thaliana GN=SINAT2 PE=2 SV=1
Length = 308
Score = 467 bits (1200), Expect = 1e-130
Identities = 213/278 (76%), Positives = 238/278 (85%), Gaps = 4/278 (1%)
Frame = +1
Query: 199 SNNSNANAAASGL----LPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHN 366
+NN ++G+ + + V+ELLECPVCTN MYPPIHQC NGHTLCS CK RV N
Sbjct: 31 NNNKPTKPGSAGIGKYGIHSNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNCKLRVQN 90
Query: 367 RCPTCRQELGDIRCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPY 546
CPTCR ELG+IRCLALEKVAESLE+PC+Y +LGC +IFPYYSKLKHE C FRPY CPY
Sbjct: 91 TCPTCRYELGNIRCLALEKVAESLEVPCRYQNLGCHDIFPYYSKLKHEQHCRFRPYTCPY 150
Query: 547 AGSECSVMGDIPFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVENATWMLTVFHCFGQY 726
AGSECSV GDIP LV HL+DDHKVDMH GCTFNHRYVKSNP EVENATWMLTVF+CFG+
Sbjct: 151 AGSECSVTGDIPTLVVHLKDDHKVDMHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQ 210
Query: 727 FCLHFEAFQLGMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRK 906
FCLHFEAFQLGMAPVYMAFLRFMGDE EA+ ++YSLEVG +GRKL W+G PRS+RDSHRK
Sbjct: 211 FCLHFEAFQLGMAPVYMAFLRFMGDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRK 270
Query: 907 VRDSHDGLIIQRNMALFFSGGDRKELKLRVTGRIWKEQ 1020
VRDS DGLII RN+AL+FSGGDR+ELKLRVTGRIWKE+
Sbjct: 271 VRDSQDGLIIPRNLALYFSGGDRQELKLRVTGRIWKEE 308
>sp|P93748|SINA1_ARATH Putative E3 ubiquitin-protein ligase SINAT1
OS=Arabidopsis thaliana GN=SINAT1 PE=2 SV=1
Length = 305
Score = 460 bits (1181), Expect = 2e-128
Identities = 208/275 (75%), Positives = 237/275 (86%)
Frame = +1
Query: 196 HSNNSNANAAASGLLPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNRCP 375
+S + + + + G ++ V+ELLECPVCTN MYPPIHQC NGHTLCS+CK RV N CP
Sbjct: 31 NSKPTKSGSGSIGKFHSSNGVYELLECPVCTNLMYPPIHQCPNGHTLCSSCKLRVQNTCP 90
Query: 376 TCRQELGDIRCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYAGS 555
TCR ELG+IRCLALEKVAESLE+PC+Y +LGC +IFPYYSKLKHE C FR Y+CPYAGS
Sbjct: 91 TCRYELGNIRCLALEKVAESLEVPCRYQNLGCQDIFPYYSKLKHEQHCRFRSYSCPYAGS 150
Query: 556 ECSVMGDIPFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVENATWMLTVFHCFGQYFCL 735
ECSV GDIP LV HL+DDHKVDMH GCTFNHRYVKSNP EVENATWMLTVF+CFG+ FCL
Sbjct: 151 ECSVTGDIPTLVDHLKDDHKVDMHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCL 210
Query: 736 HFEAFQLGMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRD 915
HFEAFQLGMAPVYMAFLRFMGDE EA+ ++YSLEVG + RKL W+G PRS+RDSHRKVRD
Sbjct: 211 HFEAFQLGMAPVYMAFLRFMGDENEAKKFSYSLEVGAHSRKLTWQGIPRSIRDSHRKVRD 270
Query: 916 SHDGLIIQRNMALFFSGGDRKELKLRVTGRIWKEQ 1020
S DGLII RN+AL+FSG D++ELKLRVTGRIWKE+
Sbjct: 271 SQDGLIIPRNLALYFSGSDKEELKLRVTGRIWKEE 305
>sp|Q86MW9|SINA_SCHMA E3 ubiquitin-protein ligase sina OS=Schistosoma mansoni
GN=SINA PE=1 SV=1
Length = 371
Score = 169 bits (428), Expect = 4e-041
Identities = 91/260 (35%), Positives = 139/260 (53%), Gaps = 13/260 (5%)
Frame = +1
Query: 208 SNANAAASGLLPTTTS------VHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNR 369
S+A+ +LP TS + L ECPVC + PPI QC +GH +C++C++++ +
Sbjct: 98 SSASDTVCNILPHNTSDSSSIDLASLFECPVCMDYALPPIMQCQSGHIVCASCRSKL-SS 156
Query: 370 CPTCRQELGDIRCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYA 549
CPTCR L +IR LA+EK+A S+ PCKY + GCPE F Y SK +HE C +RPY+CP
Sbjct: 157 CPTCRGNLDNIRNLAMEKLASSVLFPCKYSTSGCPETFHYTSKSEHEAACEYRPYDCPCP 216
Query: 550 GSECSVMGDIPFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFHCFGQ 723
G+ C +G++ ++ HL HK S T + ++ A + + CFG
Sbjct: 217 GASCKWLGELEQVMPHLVHHHK----SITTLQGEDIVFLATDISLPGAVDWVMMQSCFGH 272
Query: 724 YFCLHFEAFQLGMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHR 903
F L E + ++ A ++ +G +A + Y LE+ G+ R+L WE PRS+ D +
Sbjct: 273 SFMLVLEKQERVPDQIFFALVQLIGTRKQADQFVYRLELNGHRRRLTWEACPRSIHDGVQ 332
Query: 904 KVRDSHDGLIIQRNMALFFS 963
D L+ N A F+
Sbjct: 333 SAIAVSDCLVFDSNTAHSFA 352
>sp|Q7ZVG6|SIAH1_DANRE E3 ubiquitin-protein ligase Siah1 OS=Danio rerio GN=siah1
PE=2 SV=2
Length = 282
Score = 163 bits (412), Expect = 3e-039
Identities = 88/248 (35%), Positives = 131/248 (52%), Gaps = 8/248 (3%)
Frame = +1
Query: 229 SGLLPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNRCPTCRQELGDIRC 408
SG + + + L ECPVC + + PPI QC +GH +CS C+ ++ CPTCR LG IR
Sbjct: 26 SGTTASNSDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIRN 84
Query: 409 LALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYAGSECSVMGDIPFL 588
LA+EKVA S+ PCKY S GC P+ K +HE +C FRPY+CP G+ C G + +
Sbjct: 85 LAMEKVANSVLFPCKYASSGCEVTLPHTDKAEHEELCEFRPYSCPCPGASCKWQGSLDAV 144
Query: 589 VAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFHCFGQYFCLHFEAFQ-LG 759
+ HL HK S T + ++ A + + CFG +F L E +
Sbjct: 145 MPHLLHQHK----SITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYD 200
Query: 760 MAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDGLIIQ 939
+ A ++ +G +A N+ Y LE+ G+ R+L WE TPRS+ + + D L+
Sbjct: 201 GHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFD 260
Query: 940 RNMALFFS 963
++A F+
Sbjct: 261 TSIAQLFA 268
>sp|P61092|SIA1A_MOUSE E3 ubiquitin-protein ligase SIAH1A OS=Mus musculus
GN=Siah1a PE=1 SV=1
Length = 282
Score = 163 bits (411), Expect = 3e-039
Identities = 88/250 (35%), Positives = 131/250 (52%), Gaps = 8/250 (3%)
Frame = +1
Query: 223 AASGLLPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNRCPTCRQELGDI 402
A +G + + L ECPVC + + PPI QC +GH +CS C+ ++ CPTCR LG I
Sbjct: 24 ALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSI 82
Query: 403 RCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYAGSECSVMGDIP 582
R LA+EKVA S+ PCKY S GC P+ K +HE +C FRPY+CP G+ C G +
Sbjct: 83 RNLAMEKVANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLD 142
Query: 583 FLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFHCFGQYFCLHFEAFQ- 753
++ HL HK S T + ++ A + + CFG +F L E +
Sbjct: 143 AVMPHLMHQHK----SITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEK 198
Query: 754 LGMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDGLI 933
+ A ++ +G +A N+ Y LE+ G+ R+L WE TPRS+ + + D L+
Sbjct: 199 YDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLV 258
Query: 934 IQRNMALFFS 963
++A F+
Sbjct: 259 FDTSIAQLFA 268
>sp|Q920M9|SIAH1_RAT E3 ubiquitin-protein ligase SIAH1 OS=Rattus norvegicus
GN=Siah1 PE=1 SV=2
Length = 282
Score = 163 bits (411), Expect = 3e-039
Identities = 88/250 (35%), Positives = 131/250 (52%), Gaps = 8/250 (3%)
Frame = +1
Query: 223 AASGLLPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNRCPTCRQELGDI 402
A +G + + L ECPVC + + PPI QC +GH +CS C+ ++ CPTCR LG I
Sbjct: 24 ALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSI 82
Query: 403 RCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYAGSECSVMGDIP 582
R LA+EKVA S+ PCKY S GC P+ K +HE +C FRPY+CP G+ C G +
Sbjct: 83 RNLAMEKVANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLD 142
Query: 583 FLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFHCFGQYFCLHFEAFQ- 753
++ HL HK S T + ++ A + + CFG +F L E +
Sbjct: 143 AVMPHLMHQHK----SITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEK 198
Query: 754 LGMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDGLI 933
+ A ++ +G +A N+ Y LE+ G+ R+L WE TPRS+ + + D L+
Sbjct: 199 YDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLV 258
Query: 934 IQRNMALFFS 963
++A F+
Sbjct: 259 FDTSIAQLFA 268
>sp|Q8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 OS=Homo sapiens
GN=SIAH1 PE=1 SV=2
Length = 282
Score = 162 bits (409), Expect = 6e-039
Identities = 88/250 (35%), Positives = 130/250 (52%), Gaps = 8/250 (3%)
Frame = +1
Query: 223 AASGLLPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNRCPTCRQELGDI 402
A +G + + L ECPVC + + PPI QC +GH +CS C+ ++ CPTCR LG I
Sbjct: 24 ALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSI 82
Query: 403 RCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYAGSECSVMGDIP 582
R LA+EKVA S+ PCKY S GC P+ K HE +C FRPY+CP G+ C G +
Sbjct: 83 RNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLD 142
Query: 583 FLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFHCFGQYFCLHFEAFQ- 753
++ HL HK S T + ++ A + + CFG +F L E +
Sbjct: 143 AVMPHLMHQHK----SITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEK 198
Query: 754 LGMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDGLI 933
+ A ++ +G +A N+ Y LE+ G+ R+L WE TPRS+ + + D L+
Sbjct: 199 YDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLV 258
Query: 934 IQRNMALFFS 963
++A F+
Sbjct: 259 FDTSIAQLFA 268
>sp|Q06985|SIA1B_MOUSE E3 ubiquitin-protein ligase SIAH1B OS=Mus musculus
GN=Siah1b PE=2 SV=2
Length = 282
Score = 159 bits (402), Expect = 4e-038
Identities = 89/249 (35%), Positives = 132/249 (53%), Gaps = 11/249 (4%)
Frame = +1
Query: 235 LLPTTTSVHE---LLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNRCPTCRQELGDIR 405
L TT S ++ L ECPVC + + PPI QC +GH +CS C+ ++ CPTCR LG IR
Sbjct: 25 LTDTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIR 83
Query: 406 CLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYAGSECSVMGDIPF 585
LA+EKVA S+ PCKY + GC P+ K +HE +C FRPY+CP G+ C G +
Sbjct: 84 NLAVEKVANSVLFPCKYSASGCEITLPHTKKAEHEELCEFRPYSCPCPGASCKWQGSLDA 143
Query: 586 LVAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFHCFGQYFCLHFEAFQ-L 756
++ HL HK S T + ++ A + + CFG +F L E +
Sbjct: 144 VMPHLMHQHK----SITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKY 199
Query: 757 GMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDGLII 936
+ A ++ +G +A N+ Y LE+ G+ R+L WE TPRS+ + + D L+
Sbjct: 200 DGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVF 259
Query: 937 QRNMALFFS 963
++A F+
Sbjct: 260 DTSIAQLFA 268
>sp|P61093|SINA_DROER E3 ubiquitin-protein ligase sina OS=Drosophila erecta
GN=sina PE=3 SV=1
Length = 314
Score = 156 bits (392), Expect = 5e-037
Identities = 89/277 (32%), Positives = 140/277 (50%), Gaps = 10/277 (3%)
Frame = +1
Query: 178 ASVSKHHSNNSNANAAASGLLPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNR 357
+S + S++S+ ++A G + + L ECPVC + + PPI QC +GH +C +C+++
Sbjct: 41 SSANTSSSSSSSLSSAGGGDAGMSADLTSLFECPVCFDYVLPPILQCSSGHLVCVSCRSK 100
Query: 358 VHNRCPTCRQELGDIRCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYN 537
+ CPTCR L +IR LA+EKVA +++ PCK+ GC Y K +HE C RPY
Sbjct: 101 L-TCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEKTEHEETCECRPYL 159
Query: 538 CPYAGSECSVMGDIPFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFH 711
CP G+ C G + ++ HL HK S T + ++ A + +
Sbjct: 160 CPCPGASCKWQGPLDLVMQHLMMSHK----SITTLQGEDIVFLATDINLPGAVDWVMMQS 215
Query: 712 CFGQYFCLHFEAFQ-LGMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSV 888
CFG +F L E + + A ++ +G EA N+ Y LE+ G R+L WE PRS+
Sbjct: 216 CFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLTWEAMPRSI 275
Query: 889 RDSHRKVRDSHDGLIIQRNMALFFSGGDRKELKLRVT 999
+ + D L+ ++A F+ D L + VT
Sbjct: 276 HEGVASAIHNSDCLVFDTSIAQLFA--DNGNLGINVT 310
>sp|P21461|SINA_DROME E3 ubiquitin-protein ligase sina OS=Drosophila
melanogaster GN=sina PE=1 SV=2
Length = 314
Score = 156 bits (392), Expect = 5e-037
Identities = 89/277 (32%), Positives = 140/277 (50%), Gaps = 10/277 (3%)
Frame = +1
Query: 178 ASVSKHHSNNSNANAAASGLLPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNR 357
+S + S++S+ ++A G + + L ECPVC + + PPI QC +GH +C +C+++
Sbjct: 41 SSANTSSSSSSSLSSAGGGDAGMSADLTSLFECPVCFDYVLPPILQCSSGHLVCVSCRSK 100
Query: 358 VHNRCPTCRQELGDIRCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYN 537
+ CPTCR L +IR LA+EKVA +++ PCK+ GC Y K +HE C RPY
Sbjct: 101 L-TCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEKTEHEETCECRPYL 159
Query: 538 CPYAGSECSVMGDIPFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFH 711
CP G+ C G + ++ HL HK S T + ++ A + +
Sbjct: 160 CPCPGASCKWQGPLDLVMQHLMMSHK----SITTLQGEDIVFLATDINLPGAVDWVMMQS 215
Query: 712 CFGQYFCLHFEAFQ-LGMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSV 888
CFG +F L E + + A ++ +G EA N+ Y LE+ G R+L WE PRS+
Sbjct: 216 CFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLTWEAMPRSI 275
Query: 889 RDSHRKVRDSHDGLIIQRNMALFFSGGDRKELKLRVT 999
+ + D L+ ++A F+ D L + VT
Sbjct: 276 HEGVASAIHNSDCLVFDTSIAQLFA--DNGNLGINVT 310
>sp|Q8I147|SINA_DROWI E3 ubiquitin-protein ligase sina OS=Drosophila willistoni
GN=sina PE=3 SV=1
Length = 331
Score = 156 bits (392), Expect = 5e-037
Identities = 89/277 (32%), Positives = 140/277 (50%), Gaps = 10/277 (3%)
Frame = +1
Query: 178 ASVSKHHSNNSNANAAASGLLPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNR 357
+S + S++S+ ++A G + + L ECPVC + + PPI QC +GH +C +C+++
Sbjct: 58 SSANTSSSSSSSLSSAGGGDAGMSADLTSLFECPVCFDYVLPPILQCSSGHLVCVSCRSK 117
Query: 358 VHNRCPTCRQELGDIRCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYN 537
+ CPTCR L +IR LA+EKVA +++ PCK+ GC Y K +HE C RPY
Sbjct: 118 L-TCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEKTEHEETCECRPYL 176
Query: 538 CPYAGSECSVMGDIPFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFH 711
CP G+ C G + ++ HL HK S T + ++ A + +
Sbjct: 177 CPCPGASCKWQGPLDLVMQHLMMSHK----SITTLQGEDIVFLATDINLPGAVDWVMMQS 232
Query: 712 CFGQYFCLHFEAFQ-LGMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSV 888
CFG +F L E + + A ++ +G EA N+ Y LE+ G R+L WE PRS+
Sbjct: 233 CFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLTWEAMPRSI 292
Query: 889 RDSHRKVRDSHDGLIIQRNMALFFSGGDRKELKLRVT 999
+ + D L+ ++A F+ D L + VT
Sbjct: 293 HEGVASAIHNSDCLVFDTSIAQLFA--DNGNLGINVT 327
>sp|P29304|SINA_DROVI E3 ubiquitin-protein ligase sina OS=Drosophila virilis
GN=sina PE=3 SV=1
Length = 314
Score = 154 bits (388), Expect = 2e-036
Identities = 88/277 (31%), Positives = 140/277 (50%), Gaps = 10/277 (3%)
Frame = +1
Query: 178 ASVSKHHSNNSNANAAASGLLPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNR 357
+S + S++S+ ++A G + + L ECPVC + + PPI QC +GH +C +C+++
Sbjct: 41 SSANTSSSSSSSLSSAGGGDAGMSADLTSLFECPVCFDYVLPPILQCSSGHLVCVSCRSK 100
Query: 358 VHNRCPTCRQELGDIRCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYN 537
+ CPTCR L +IR LA+E+VA +++ PCK+ GC Y K +HE C RPY
Sbjct: 101 L-TCCPTCRGPLANIRNLAMEEVASNVKFPCKHSGYGCTASLVYTEKTEHEETCECRPYL 159
Query: 538 CPYAGSECSVMGDIPFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFH 711
CP G+ C G + ++ HL HK S T + ++ A + +
Sbjct: 160 CPCPGASCKWQGPLDLVMQHLMMSHK----SITTLQGEDIVFLATDINLPGAVDWVMMQS 215
Query: 712 CFGQYFCLHFEAFQ-LGMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSV 888
CFG +F L E + + A ++ +G EA N+ Y LE+ G R+L WE PRS+
Sbjct: 216 CFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLTWEAMPRSI 275
Query: 889 RDSHRKVRDSHDGLIIQRNMALFFSGGDRKELKLRVT 999
+ + D L+ ++A F+ D L + VT
Sbjct: 276 HEGVASAIHNSDCLVFDTSIAQLFA--DNGNLGINVT 310
>sp|Q8T3Y0|SINAL_DROME Probable E3 ubiquitin-protein ligase sinah OS=Drosophila
melanogaster GN=sinah PE=1 SV=2
Length = 351
Score = 150 bits (377), Expect = 3e-035
Identities = 89/255 (34%), Positives = 126/255 (49%), Gaps = 15/255 (5%)
Frame = +1
Query: 226 ASGLLPTTTS------VHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNRCPTCRQ 387
A+G L TT S + LLECPVC + PPI QC GH +CSTC++++ CP CR
Sbjct: 84 ATGPLDTTRSGARDDFLMALLECPVCFGYIMPPIMQCPRGHLICSTCRSKL-TICPVCRV 142
Query: 388 ELGDIRCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYAGSECSV 567
+ +IR LA+EKVA L PCK+ GC Y K KHE C RPY CPY +CS
Sbjct: 143 FMTNIRSLAMEKVASKLIFPCKHSHFGCRARLSYAEKTKHEEDCECRPYFCPYPDDKCSW 202
Query: 568 MGDIPFLVAHLRDDHK--VDMHSGCTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHF 741
G + + HL H+ + M N + +E A V C G++F L
Sbjct: 203 QGPLRDVYQHLMSSHENVITMEG----NDIIFLATNVNLEGALDWTMVQSCHGRHFLLSL 258
Query: 742 EAFQLGM-APVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDS 918
E LG Y R +G +A + Y++ + Y R L W+ PRS+R++ ++
Sbjct: 259 EKINLGEDCQQYFTACRMIGSMKDAAEFVYNISLEAYNRTLRWQSKPRSIRENFSSFTNA 318
Query: 919 HDGLIIQRNMALFFS 963
D L++ ++ FS
Sbjct: 319 -DFLVLNKHTVELFS 332
>sp|Q7SYL3|SIAH2_DANRE E3 ubiquitin-protein ligase Siah2 OS=Danio rerio
GN=siah2l PE=2 SV=2
Length = 331
Score = 149 bits (376), Expect = 4e-035
Identities = 94/264 (35%), Positives = 132/264 (50%), Gaps = 14/264 (5%)
Frame = +1
Query: 220 AAASGLLPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNRCPTCRQEL-G 396
AA G P T+ L ECPVC + + PPI QC GH +C+ C+ ++ + CPTCR L
Sbjct: 74 AALPGQSPELTA---LFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPTCRGPLTP 129
Query: 397 DIRCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYAGSECSVMGD 576
IR LA+EKVA +L PCKY S GC + K +HE VC FRPY CP G+ C G
Sbjct: 130 SIRNLAMEKVASTLPFPCKYSSAGCLLSLHHSEKPEHEEVCEFRPYTCPCPGASCKWQGS 189
Query: 577 IPFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFHCFGQYFCLHFEAF 750
+ ++ HL HK S T + ++ A + + CFG +F L E
Sbjct: 190 LEEVMPHLMHAHK----SITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQ 245
Query: 751 QLGMA-PVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDG 927
+ + A + +G +A N+ Y LE+ G R+L WE TPRS+ D + D
Sbjct: 246 EKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDC 305
Query: 928 LIIQRNMALFFSGGDRKELKLRVT 999
L+ ++A F+ D L + VT
Sbjct: 306 LVFDTSIAHLFA--DNGNLGINVT 327
>sp|Q06986|SIAH2_MOUSE E3 ubiquitin-protein ligase SIAH2 OS=Mus musculus
GN=Siah2 PE=1 SV=2
Length = 325
Score = 148 bits (371), Expect = 1e-034
Identities = 90/266 (33%), Positives = 133/266 (50%), Gaps = 14/266 (5%)
Frame = +1
Query: 223 AASGLLPTTTSVHE---LLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNRCPTCRQEL 393
A G P + HE L ECPVC + + PPI QC GH +C+ C+ ++ + CPTCR L
Sbjct: 61 AGGGADPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPTCRGAL 119
Query: 394 -GDIRCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYAGSECSVM 570
IR LA+EKVA ++ PCKY + GC + K +HE +C +RPY+CP G+ C
Sbjct: 120 TPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQ 179
Query: 571 GDIPFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFHCFGQYFCLHFE 744
G + +++HL HK S T + ++ A + + CFG +F L E
Sbjct: 180 GSLEAVMSHLMHAHK----SITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLE 235
Query: 745 AFQLGMA-PVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSH 921
+ + A + +G +A N+ Y LE+ G R+L WE TPRS+ D +
Sbjct: 236 KQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNS 295
Query: 922 DGLIIQRNMALFFSGGDRKELKLRVT 999
D L+ +A F+ D L + VT
Sbjct: 296 DCLVFDTAIAHLFA--DNGNLGINVT 319
>sp|Q8R4T2|SIAH2_RAT E3 ubiquitin-protein ligase SIAH2 OS=Rattus norvegicus
GN=Siah2 PE=1 SV=2
Length = 325
Score = 148 bits (371), Expect = 1e-034
Identities = 90/266 (33%), Positives = 133/266 (50%), Gaps = 14/266 (5%)
Frame = +1
Query: 223 AASGLLPTTTSVHE---LLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNRCPTCRQEL 393
A G P + HE L ECPVC + + PPI QC GH +C+ C+ ++ + CPTCR L
Sbjct: 61 AGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPTCRGAL 119
Query: 394 -GDIRCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYAGSECSVM 570
IR LA+EKVA ++ PCKY + GC + K +HE +C +RPY+CP G+ C
Sbjct: 120 TPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQ 179
Query: 571 GDIPFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFHCFGQYFCLHFE 744
G + +++HL HK S T + ++ A + + CFG +F L E
Sbjct: 180 GSLEAVMSHLMHAHK----SITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLE 235
Query: 745 AFQLGMA-PVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSH 921
+ + A + +G +A N+ Y LE+ G R+L WE TPRS+ D +
Sbjct: 236 KQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNS 295
Query: 922 DGLIIQRNMALFFSGGDRKELKLRVT 999
D L+ +A F+ D L + VT
Sbjct: 296 DCLVFDTAIAHLFA--DNGNLGINVT 319
>sp|O43255|SIAH2_HUMAN E3 ubiquitin-protein ligase SIAH2 OS=Homo sapiens
GN=SIAH2 PE=1 SV=1
Length = 324
Score = 146 bits (367), Expect = 4e-034
Identities = 89/263 (33%), Positives = 132/263 (50%), Gaps = 14/263 (5%)
Frame = +1
Query: 232 GLLPTTTSVHE---LLECPVCTNSMYPPIHQCHNGHTLCSTCKNRVHNRCPTCRQEL-GD 399
G P + HE L ECPVC + + PPI QC GH +C+ C+ ++ + CPTCR L
Sbjct: 63 GAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPTCRGALTPS 121
Query: 400 IRCLALEKVAESLELPCKYMSLGCPEIFPYYSKLKHETVCNFRPYNCPYAGSECSVMGDI 579
IR LA+EKVA ++ PCKY + GC + K +HE +C +RPY+CP G+ C G +
Sbjct: 122 IRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSL 181
Query: 580 PFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVE--NATWMLTVFHCFGQYFCLHFEAFQ 753
+++HL HK S T + ++ A + + CFG +F L E +
Sbjct: 182 EAVMSHLMHAHK----SITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQE 237
Query: 754 LGMA-PVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDGL 930
+ A + +G +A N+ Y LE+ G R+L WE TPRS+ D + D L
Sbjct: 238 KYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCL 297
Query: 931 IIQRNMALFFSGGDRKELKLRVT 999
+ +A F+ D L + VT
Sbjct: 298 VFDTAIAHLFA--DNGNLGINVT 318
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,281,224,270
Number of Sequences: 518415
Number of Extensions: 55281224270
Number of Successful Extensions: 373770181
Number of sequences better than 0.0: 0
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