BLASTX 7.6.2
Query= UN14058 /QuerySize=1391
(1390 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O04420|URIC_ARATH Uricase OS=Arabidopsis thaliana GN=At2g2623... 567 1e-160
sp|P53763|URIC_PHAVU Uricase-2 OS=Phaseolus vulgaris GN=URIII PE... 445 4e-124
sp|P04670|URIC1_SOYBN Uricase-2 isozyme 1 OS=Glycine max PE=1 SV=2 438 6e-122
sp|O04104|URIC2_SOYBN Uricase-2 isozyme 2 OS=Glycine max PE=1 SV=1 438 6e-122
sp|P34798|URIC1_CANLI Uricase-2 isozyme 1 OS=Canavalia lineata P... 433 2e-120
sp|P34799|URIC2_CANLI Uricase-2 isozyme 2 OS=Canavalia lineata P... 427 1e-118
sp|P11645|URIC_RABIT Uricase OS=Oryctolagus cuniculus GN=UOX PE=... 172 6e-042
sp|P16164|URIC_PIG Uricase OS=Sus scrofa GN=UOX PE=2 SV=3 171 2e-041
sp|Q5FZI9|URIC_CANFA Uricase OS=Canis familiaris GN=UOX PE=2 SV=3 170 3e-041
sp|Q8MHW6|URIC_MACFA Uricase OS=Macaca fascicularis GN=UOX PE=3 ... 169 7e-041
sp|P25689|URIC_PAPHA Uricase OS=Papio hamadryas GN=UOX PE=2 SV=3 169 7e-041
sp|Q8MKJ3|URIC_MACMU Uricase OS=Macaca mulatta GN=UOX PE=3 SV=3 168 2e-040
sp|Q8MKJ2|URIC_AOTTR Uricase OS=Aotus trivirgatus GN=UOX PE=3 SV=3 167 2e-040
sp|Q3MHG7|URIC_BOVIN Uricase OS=Bos taurus GN=UOX PE=2 SV=3 167 2e-040
sp|Q54LT2|URIC_DICDI Uricase OS=Dictyostelium discoideum GN=uox ... 136 4e-031
sp|P25688|URIC_MOUSE Uricase OS=Mus musculus GN=Uox PE=1 SV=2 123 3e-027
sp|P09118|URIC_RAT Uricase OS=Rattus norvegicus GN=Uox PE=1 SV=3 123 4e-027
sp|P22673|URIC_DROPS Uricase OS=Drosophila pseudoobscura pseudoo... 108 1e-022
sp|O44111|URIC_DROSU Uricase (Fragment) OS=Drosophila subobscura... 108 1e-022
sp|P16163|URIC_DROME Uricase OS=Drosophila melanogaster GN=Uro P... 106 5e-022
>sp|O04420|URIC_ARATH Uricase OS=Arabidopsis thaliana GN=At2g26230 PE=1 SV=2
Length = 309
Score = 567 bits (1459), Expect = 1e-160
Identities = 275/305 (90%), Positives = 290/305 (95%)
Frame = +2
Query: 134 AEGLRVDQRHGKARVRVGRVWRQGLDGSHHFVEWNVSISLLSHCLSSYHRDDNSDIVATD 313
A+G+R+DQRHGKARVRVGRVWR DGSHHFVEWNVSISLLSHCLSSY DDNSDIVATD
Sbjct: 5 ADGIRLDQRHGKARVRVGRVWRHAHDGSHHFVEWNVSISLLSHCLSSYRLDDNSDIVATD 64
Query: 314 TMKNTVYVKAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHL 493
T+KNTVYVKAKECGDRLSVEEFAIL+G HFCSFYPQV+TAIVNIIEKPWERV IDGKPHL
Sbjct: 65 TIKNTVYVKAKECGDRLSVEEFAILIGKHFCSFYPQVFTAIVNIIEKPWERVSIDGKPHL 124
Query: 494 HGFKLGSENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERML 673
HGFKLGSENHT EA V KSGAL LTSG+ GLALLKTTQSGFE+FVRDKYTILP+TRERML
Sbjct: 125 HGFKLGSENHTTEARVEKSGALNLTSGIGGLALLKTTQSGFERFVRDKYTILPETRERML 184
Query: 674 ATEVNASWRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLM 853
ATEVNASWRYSYESVASIP K LYF+EKFM+VKKVLMDTFFGPPETGVYSPSVQRTLYLM
Sbjct: 185 ATEVNASWRYSYESVASIPTKGLYFSEKFMDVKKVLMDTFFGPPETGVYSPSVQRTLYLM 244
Query: 854 GGAVLRRFADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSIEATLSR 1033
G AVL+RFADV+SIHLKMPNIHFLPVNLS+KENPSMVKFKDDVYLPTDEPHGSIEATLSR
Sbjct: 245 GSAVLKRFADVSSIHLKMPNIHFLPVNLSTKENPSMVKFKDDVYLPTDEPHGSIEATLSR 304
Query: 1034 ITSKM 1048
ITSK+
Sbjct: 305 ITSKL 309
>sp|P53763|URIC_PHAVU Uricase-2 OS=Phaseolus vulgaris GN=URIII PE=1 SV=2
Length = 308
Score = 445 bits (1144), Expect = 4e-124
Identities = 216/304 (71%), Positives = 250/304 (82%), Gaps = 2/304 (0%)
Frame = +2
Query: 137 EGLRVDQRHGKARVRVGRVWRQGLDGSHHFVEWNVSISLLSHCLSSYHRDDNSDIVATDT 316
EG + +QRHGK RVRV RVWR G H VEW V I+L S C++SY RDDNSDIVATDT
Sbjct: 7 EGFKFEQRHGKERVRVARVWRTP-QGRHFVVEWRVGITLFSDCVNSYLRDDNSDIVATDT 65
Query: 317 MKNTVYVKAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLH 496
MKNTVY KAKEC D LSVE+FAILL HF SFY +V AIVNI+EKPWERV +DG+PH H
Sbjct: 66 MKNTVYAKAKECSDILSVEDFAILLAKHFVSFYKKVTGAIVNIVEKPWERVIVDGQPHQH 125
Query: 497 GFKLGSENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLA 676
GF LGSE HT EA V KSG+L LTSG+ GL++LKTTQSGFE F+R+KYT LPDTRER+LA
Sbjct: 126 GFTLGSEKHTTEAIVQKSGSLQLTSGIEGLSVLKTTQSGFENFIRNKYTALPDTRERILA 185
Query: 677 TEVNASWRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMG 856
TEV A WRYSYES+ ++P+K LYF +K++EVKKVL DTFFGPP GVYSPSVQ TLYLM
Sbjct: 186 TEVTALWRYSYESLYNLPQKPLYFTDKYLEVKKVLADTFFGPPNRGVYSPSVQNTLYLMA 245
Query: 857 GAVLRRFADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSIEATLSRI 1036
A L RF D+A +HLKMPN+HFLPVN+SSK+ P +VKF+DDVYLPTDEPHGSIEA+LSR+
Sbjct: 246 KATLNRFPDIAYVHLKMPNLHFLPVNISSKDGP-IVKFEDDVYLPTDEPHGSIEASLSRV 304
Query: 1037 TSKM 1048
SK+
Sbjct: 305 WSKL 308
>sp|P04670|URIC1_SOYBN Uricase-2 isozyme 1 OS=Glycine max PE=1 SV=2
Length = 309
Score = 438 bits (1125), Expect = 6e-122
Identities = 212/304 (69%), Positives = 248/304 (81%), Gaps = 2/304 (0%)
Frame = +2
Query: 137 EGLRVDQRHGKARVRVGRVWRQGLDGSHHFVEWNVSISLLSHCLSSYHRDDNSDIVATDT 316
EG + +QRHGK RVRV RVW+ G H VEW V I+L S C++SY RDDNSDIVATDT
Sbjct: 8 EGFKFEQRHGKERVRVARVWKT-RQGQHFIVEWRVGITLFSDCVNSYLRDDNSDIVATDT 66
Query: 317 MKNTVYVKAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLH 496
MKNTVY KAKEC D LS EEFAILL HF SFY +V AIVNI+EKPWERV +DG+PH H
Sbjct: 67 MKNTVYAKAKECSDILSAEEFAILLAKHFVSFYQKVTGAIVNIVEKPWERVTVDGQPHEH 126
Query: 497 GFKLGSENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLA 676
GFKLGSE HT EA V KSG+L LTSG+ GL++LKTTQSGF F+RDKYT LPDTRERM+A
Sbjct: 127 GFKLGSEKHTTEAIVQKSGSLQLTSGIEGLSVLKTTQSGFVNFIRDKYTALPDTRERMVA 186
Query: 677 TEVNASWRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMG 856
TEV A WRYSYES+ S+P+K LYF EK+ EVKKVL DTFFGPP+ GVYSPSVQ TLYLM
Sbjct: 187 TEVTALWRYSYESLYSLPQKPLYFTEKYQEVKKVLADTFFGPPKGGVYSPSVQNTLYLMA 246
Query: 857 GAVLRRFADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSIEATLSRI 1036
A L RF D+A + LK+PN+HF+PVN+S+++ P +VKF+DDVYLPTDEPHGSI+A+LSR+
Sbjct: 247 KATLNRFPDIAYVSLKLPNLHFIPVNISNQDGP-IVKFEDDVYLPTDEPHGSIQASLSRL 305
Query: 1037 TSKM 1048
SK+
Sbjct: 306 WSKL 309
>sp|O04104|URIC2_SOYBN Uricase-2 isozyme 2 OS=Glycine max PE=1 SV=1
Length = 309
Score = 438 bits (1125), Expect = 6e-122
Identities = 214/304 (70%), Positives = 246/304 (80%), Gaps = 2/304 (0%)
Frame = +2
Query: 137 EGLRVDQRHGKARVRVGRVWRQGLDGSHHFVEWNVSISLLSHCLSSYHRDDNSDIVATDT 316
EG + +QRHGK RVRV RVW+ G H VEW V I+L S C++SY RDDNSDIVATDT
Sbjct: 8 EGFKFEQRHGKERVRVARVWKT-RQGQHFVVEWRVGITLFSDCVNSYLRDDNSDIVATDT 66
Query: 317 MKNTVYVKAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLH 496
MKNTVY KAKEC D LS E+FAILL HF SFY +V AIVNI+EKPWERV +DG+PH H
Sbjct: 67 MKNTVYAKAKECSDILSAEDFAILLAKHFVSFYKKVTGAIVNIVEKPWERVIVDGQPHEH 126
Query: 497 GFKLGSENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLA 676
GFKLGSE HT EA V KSG+L LTSG+ GL++LKTTQSGF F+RDKYT LPDTRER+LA
Sbjct: 127 GFKLGSEKHTTEAIVQKSGSLQLTSGIEGLSVLKTTQSGFVNFIRDKYTALPDTRERILA 186
Query: 677 TEVNASWRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMG 856
TEV A WRYSYES S+P+K LYF EK+ EVKKVL DTFFGPP GVYSPSVQ TLYLM
Sbjct: 187 TEVTALWRYSYESQYSLPQKPLYFTEKYQEVKKVLADTFFGPPNGGVYSPSVQNTLYLMA 246
Query: 857 GAVLRRFADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSIEATLSRI 1036
A L RF D+A + LKMPN+HFLPVN+S+K+ P +VKF+DDVYLPTDEPHGSI+A+LSR+
Sbjct: 247 KATLNRFPDIAYVSLKMPNLHFLPVNISNKDGP-IVKFEDDVYLPTDEPHGSIQASLSRL 305
Query: 1037 TSKM 1048
SK+
Sbjct: 306 WSKL 309
>sp|P34798|URIC1_CANLI Uricase-2 isozyme 1 OS=Canavalia lineata PE=2 SV=1
Length = 308
Score = 433 bits (1112), Expect = 2e-120
Identities = 214/302 (70%), Positives = 245/302 (81%), Gaps = 2/302 (0%)
Frame = +2
Query: 140 GLRVDQRHGKARVRVGRVWRQGLDGSHHFVEWNVSISLLSHCLSSYHRDDNSDIVATDTM 319
G + DQRHGK RV+V RVW+ G + VEW V SLLS C++SY RDDNSDIVATDTM
Sbjct: 8 GFKFDQRHGKERVQVARVWKT-KQGWYFIVEWRVGNSLLSDCVNSYVRDDNSDIVATDTM 66
Query: 320 KNTVYVKAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLHG 499
KNTVY KAKEC + LSVE+FAILL HF SFY QV AIVNI+EKPWERV +DG+PH HG
Sbjct: 67 KNTVYAKAKECSEILSVEDFAILLAKHFISFYKQVTAAIVNIVEKPWERVSVDGQPHEHG 126
Query: 500 FKLGSENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLAT 679
FKLGSE HT EA V KSGAL LTSG+ GL+LLKTT+SGFE F+RDKYT LP+T ERMLAT
Sbjct: 127 FKLGSERHTAEAIVQKSGALQLTSGIEGLSLLKTTKSGFEGFIRDKYTALPETHERMLAT 186
Query: 680 EVNASWRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMGG 859
EV A WRYSYES+ SIP+K LYF +K++EVKKVL D FFGPP GVYSPSVQ TLYLM
Sbjct: 187 EVTALWRYSYESLYSIPQKPLYFTDKYLEVKKVLADNFFGPPNVGVYSPSVQNTLYLMAK 246
Query: 860 AVLRRFADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSIEATLSRIT 1039
A L RF ++ASI LKMPNIHFLPVN+S+K+ P +VKF+ DVYLPTDEPHGSI+A+L R+
Sbjct: 247 AALNRFPEIASIQLKMPNIHFLPVNISNKDGP-IVKFEADVYLPTDEPHGSIQASLRRLW 305
Query: 1040 SK 1045
SK
Sbjct: 306 SK 307
>sp|P34799|URIC2_CANLI Uricase-2 isozyme 2 OS=Canavalia lineata PE=2 SV=1
Length = 301
Score = 427 bits (1096), Expect = 1e-118
Identities = 214/303 (70%), Positives = 243/303 (80%), Gaps = 9/303 (2%)
Frame = +2
Query: 140 GLRVDQRHGKARVRVGRVWRQGLDGSHHFVEWNVSISLLSHCLSSYHRDDNSDIVATDTM 319
G + DQRHGK RVRV RVW+ G + VEW V ISLLS C++SY RDDNSDIVATDTM
Sbjct: 8 GFKFDQRHGKERVRVARVWKT-KKGGYFIVEWRVGISLLSDCVNSYVRDDNSDIVATDTM 66
Query: 320 KNTVYVKAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLHG 499
KNTVY KAKEC + LSVE+FAILL HF SFY QV AIVNI+EKPWERV +DG+PH HG
Sbjct: 67 KNTVYAKAKECSEILSVEDFAILLAKHFISFYKQVTAAIVNIVEKPWERVSVDGQPHEHG 126
Query: 500 FKLGSENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLAT 679
FKLGSE HT EA V KSGAL LTSG+ GL+LLKTT+SGFE F+RDKYT LP+T ERMLAT
Sbjct: 127 FKLGSERHTAEAIVQKSGALQLTSGIEGLSLLKTTKSGFEGFIRDKYTALPETHERMLAT 186
Query: 680 EVNASWRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMGG 859
EV A WRYSYES+ SIP+K LYF +K++EVKKVL DTFFGPP GVYSPSVQ TLYLM
Sbjct: 187 EVTALWRYSYESLYSIPQKPLYFTDKYLEVKKVLADTFFGPPNVGVYSPSVQNTLYLMAK 246
Query: 860 AVLRRFADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSIEATLSRIT 1039
A +SI LKMPNIHFLPVN+S+K+ P +VKF DDVY PTDEPHGSI+A+LSR+
Sbjct: 247 A-------HSSIQLKMPNIHFLPVNISNKDGP-IVKFDDDVYFPTDEPHGSIQASLSRLW 298
Query: 1040 SKM 1048
SK+
Sbjct: 299 SKL 301
>sp|P11645|URIC_RABIT Uricase OS=Oryctolagus cuniculus GN=UOX PE=2 SV=1
Length = 300
Score = 172 bits (435), Expect = 6e-042
Identities = 103/287 (35%), Positives = 160/287 (55%), Gaps = 17/287 (5%)
Frame = +2
Query: 161 HGKARVRVGRVWRQGLDGSHHFV-EWNVSISLLSHCLSSYHRDDNSDIVATDTMKNTVYV 337
+GK V+V + R DG +H + E S+ L Y DNSDI+ TDT+KNTV+V
Sbjct: 17 YGKDMVKVLHIQR---DGKYHSIKEVATSVQLTLSSKQDYVYGDNSDIIPTDTIKNTVHV 73
Query: 338 KAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLHGF-KLGS 514
AK G + S+E FA+ + HF S + V V + E PW+R+ +G H+H F +
Sbjct: 74 LAKFKGIK-SIEVFAMNICEHFLSSFNHVVRVHVYVEEVPWKRLEKNGVQHVHAFIHTPT 132
Query: 515 ENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATEVNAS 694
H E +SG + SG+ L +LKTTQSGFE F++D++T LP+ ++R AT+V
Sbjct: 133 GTHFCEVEQRRSGLPVIHSGIKDLKVLKTTQSGFEGFIKDQFTTLPEVKDRCFATQVYCK 192
Query: 695 WRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMGGAVLRR 874
WRY + +++ F + V+ +++ F GP + G YSPSVQ+TLY + L R
Sbjct: 193 WRYQH-------SQDVDFEATWDIVRDTVLEKFAGPYDKGEYSPSVQKTLYDIQVLTLSR 245
Query: 875 FADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSI 1015
+ + + +PNIH+ +++S ++ K++V LP D P+G I
Sbjct: 246 VPQIEDMEISLPNIHYFNIDMSKM---GLIN-KEEVLLPLDNPYGKI 288
>sp|P16164|URIC_PIG Uricase OS=Sus scrofa GN=UOX PE=2 SV=3
Length = 304
Score = 171 bits (431), Expect = 2e-041
Identities = 101/287 (35%), Positives = 160/287 (55%), Gaps = 17/287 (5%)
Frame = +2
Query: 161 HGKARVRVGRVWRQGLDGSHHFV-EWNVSISLLSHCLSSYHRDDNSDIVATDTMKNTVYV 337
+GK ++V + R DG +H + E S+ L Y DNSD++ TDT+KNTV V
Sbjct: 21 YGKDMIKVLHIQR---DGKYHSIKEVATSVQLTLSSKKDYLHGDNSDVIPTDTIKNTVNV 77
Query: 338 KAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLHGF-KLGS 514
AK G + S+E FA+ + HF S + V A V + E PW+R +G H+H F +
Sbjct: 78 LAKFKGIK-SIETFAVTICEHFLSSFKHVIRAQVYVEEVPWKRFEKNGVKHVHAFIYTPT 136
Query: 515 ENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATEVNAS 694
H E ++G + SG+ L +LKTTQSGFE F++D++T LP+ ++R AT+V
Sbjct: 137 GTHFCEVEQIRNGPPVIHSGIKDLKVLKTTQSGFEGFIKDQFTTLPEVKDRCFATQVYCK 196
Query: 695 WRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMGGAVLRR 874
WRY +++ F + V+ +++ F GP + G YSPSVQ+TLY + L +
Sbjct: 197 WRYH-------QGRDVDFEATWDTVRSIVLQKFAGPYDKGEYSPSVQKTLYDIQVLTLGQ 249
Query: 875 FADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSI 1015
++ + + +PNIH+L +++S ++ K++V LP D P+G I
Sbjct: 250 VPEIEDMEISLPNIHYLNIDMSKM---GLIN-KEEVLLPLDNPYGRI 292
>sp|Q5FZI9|URIC_CANFA Uricase OS=Canis familiaris GN=UOX PE=2 SV=3
Length = 304
Score = 170 bits (429), Expect = 3e-041
Identities = 104/287 (36%), Positives = 161/287 (56%), Gaps = 17/287 (5%)
Frame = +2
Query: 161 HGKARVRVGRVWRQGLDGSHHFV-EWNVSISLLSHCLSSYHRDDNSDIVATDTMKNTVYV 337
+GK V+V + R DG +H + E S+ L Y DNSDI+ TDT+KNTV+V
Sbjct: 21 YGKDMVKVLHIQR---DGKYHSIKEVATSVQLTLSSKKDYVYGDNSDIIPTDTIKNTVHV 77
Query: 338 KAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLHGF-KLGS 514
AK G + S+E FA+ + HF S + V A V + E PW+R +G H+H F +
Sbjct: 78 LAKFKGIK-SIETFAMNICEHFLSSFNHVIRAQVYVEEVPWKRFEKNGVKHVHAFIHNPT 136
Query: 515 ENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATEVNAS 694
H E +SG + SG+ L +LKTTQSGFE F++D++T LP+ ++R AT+V
Sbjct: 137 GTHFCEVEQMRSGPPVIHSGIKDLKVLKTTQSGFEGFIKDQFTTLPEVKDRCFATKVYCK 196
Query: 695 WRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMGGAVLRR 874
WRY +++ F + V+ ++++ F GP + G YSPSVQ+TLY + L R
Sbjct: 197 WRYH-------QGRDVDFEATWDTVRDIVLEKFAGPYDKGEYSPSVQKTLYDIQVHSLSR 249
Query: 875 FADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSI 1015
++ + + +PNIH+ +++S ++ K++V LP D P+G I
Sbjct: 250 VPEMEDMEISLPNIHYFNIDMSKM---GLIN-KEEVLLPLDNPYGRI 292
>sp|Q8MHW6|URIC_MACFA Uricase OS=Macaca fascicularis GN=UOX PE=3 SV=3
Length = 304
Score = 169 bits (426), Expect = 7e-041
Identities = 101/287 (35%), Positives = 161/287 (56%), Gaps = 17/287 (5%)
Frame = +2
Query: 161 HGKARVRVGRVWRQGLDGSHHFV-EWNVSISLLSHCLSSYHRDDNSDIVATDTMKNTVYV 337
+GK V+V + R DG +H + E S+ L Y DNSDI+ TDT+KNTV+V
Sbjct: 21 YGKDMVKVLHIQR---DGKYHSIKEVATSVQLTLSSKKDYLHGDNSDIIPTDTIKNTVHV 77
Query: 338 KAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLHGF-KLGS 514
AK G + S+E F + + +F S + V A V + E PW+R+ +G H+H F +
Sbjct: 78 LAKFKGIK-SIEAFGVNICEYFLSSFNHVIRAQVYVEEIPWKRLEKNGVKHVHAFIHTPT 136
Query: 515 ENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATEVNAS 694
H E +SG + SG+ L +LKTTQSGFE F++D++T LP+ ++R AT+V
Sbjct: 137 GTHFCEVEQLRSGPPVIHSGIKDLKVLKTTQSGFEGFIKDQFTTLPEVKDRCFATQVYCK 196
Query: 695 WRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMGGAVLRR 874
WRY +++ F + ++ ++++ F GP + G YSPSVQ+TLY + L R
Sbjct: 197 WRYH-------QCRDVDFEATWGTIRDLVLEKFAGPYDKGEYSPSVQKTLYDIQVLSLSR 249
Query: 875 FADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSI 1015
++ + + +PNIH+ +++S ++ K++V LP D P+G I
Sbjct: 250 VPEIEDMEISLPNIHYFNIDMSKM---GLIN-KEEVLLPLDNPYGKI 292
>sp|P25689|URIC_PAPHA Uricase OS=Papio hamadryas GN=UOX PE=2 SV=3
Length = 304
Score = 169 bits (426), Expect = 7e-041
Identities = 101/287 (35%), Positives = 161/287 (56%), Gaps = 17/287 (5%)
Frame = +2
Query: 161 HGKARVRVGRVWRQGLDGSHHFV-EWNVSISLLSHCLSSYHRDDNSDIVATDTMKNTVYV 337
+GK V+V + R DG +H + E S+ L Y DNSDI+ TDT+KNTV+V
Sbjct: 21 YGKDMVKVLHIQR---DGKYHSIKEVATSVQLTLSSKKDYLHGDNSDIIPTDTIKNTVHV 77
Query: 338 KAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLHGF-KLGS 514
AK G + S+E F + + +F S + V A V + E PW+R+ +G H+H F +
Sbjct: 78 LAKFKGIK-SIEAFGVNICEYFLSSFNHVIRAQVYVEEIPWKRLEKNGVKHVHAFIHTPT 136
Query: 515 ENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATEVNAS 694
H E +SG + SG+ L +LKTTQSGFE F++D++T LP+ ++R AT+V
Sbjct: 137 GTHFCEVEQLRSGPPVIHSGIKDLKVLKTTQSGFEGFIKDQFTTLPEVKDRCFATQVYCK 196
Query: 695 WRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMGGAVLRR 874
WRY +++ F + ++ ++++ F GP + G YSPSVQ+TLY + L R
Sbjct: 197 WRYH-------QCRDVDFEATWGTIRDLVLEKFAGPYDKGEYSPSVQKTLYDIQVLSLSR 249
Query: 875 FADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSI 1015
++ + + +PNIH+ +++S ++ K++V LP D P+G I
Sbjct: 250 VPEIEDMEISLPNIHYFNIDMSKM---GLIN-KEEVLLPLDNPYGKI 292
>sp|Q8MKJ3|URIC_MACMU Uricase OS=Macaca mulatta GN=UOX PE=3 SV=3
Length = 304
Score = 168 bits (423), Expect = 2e-040
Identities = 101/287 (35%), Positives = 160/287 (55%), Gaps = 17/287 (5%)
Frame = +2
Query: 161 HGKARVRVGRVWRQGLDGSHHFV-EWNVSISLLSHCLSSYHRDDNSDIVATDTMKNTVYV 337
+GK V+V + R DG +H + E S+ L Y DNSDI+ TDT+KNTV+V
Sbjct: 21 YGKDMVKVLHIQR---DGKYHSIKEVATSVQLTLSSKKDYLHGDNSDIIPTDTIKNTVHV 77
Query: 338 KAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLHGF-KLGS 514
AK G + S+E F + + +F S + V A V + E PW+R+ +G H+H F +
Sbjct: 78 LAKFKGIK-SIEAFGVNICEYFLSSFNHVIRAQVYVEEIPWKRLEKNGVKHVHAFIHTPT 136
Query: 515 ENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATEVNAS 694
H E +SG + SG L +LKTTQSGFE F++D++T LP+ ++R AT+V
Sbjct: 137 GTHFCEVEQLRSGPPVIHSGTKDLKVLKTTQSGFEGFIKDQFTTLPEVKDRCFATQVYCK 196
Query: 695 WRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMGGAVLRR 874
WRY +++ F + ++ ++++ F GP + G YSPSVQ+TLY + L R
Sbjct: 197 WRYH-------QCRDVDFEATWGTIRDLVLEKFAGPYDKGEYSPSVQKTLYDIQVLSLSR 249
Query: 875 FADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSI 1015
++ + + +PNIH+ +++S ++ K++V LP D P+G I
Sbjct: 250 VPEIEDMEISLPNIHYFNIDMSKM---GLIN-KEEVLLPLDNPYGKI 292
>sp|Q8MKJ2|URIC_AOTTR Uricase OS=Aotus trivirgatus GN=UOX PE=3 SV=3
Length = 304
Score = 167 bits (422), Expect = 2e-040
Identities = 100/287 (34%), Positives = 159/287 (55%), Gaps = 17/287 (5%)
Frame = +2
Query: 161 HGKARVRVGRVWRQGLDGSHHFV-EWNVSISLLSHCLSSYHRDDNSDIVATDTMKNTVYV 337
+GK V+V + R DG +H + E S+ L Y DNSDI+ TDT+KNTV+
Sbjct: 21 YGKDMVKVLHIQR---DGKYHSIKEVATSVQLTLSSKKDYLHGDNSDIIPTDTIKNTVHA 77
Query: 338 KAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLHGF-KLGS 514
AK G + S+E FA+ + HF S + V V + E PW+R+ +G H+H F +
Sbjct: 78 LAKFKGIK-SIEAFAVNICQHFLSSFNHVIRTQVYVEEIPWKRLEKNGVKHVHAFIHTPT 136
Query: 515 ENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATEVNAS 694
H E +SG + SG+ L +LKTTQSGFE F++D++T LP+ ++R A +V
Sbjct: 137 GTHFCEVEQLRSGPPVIHSGIKDLKVLKTTQSGFEGFIKDQFTTLPEVKDRCFAAQVYCK 196
Query: 695 WRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMGGAVLRR 874
WRY +++ F + ++ V+++ F GP + G YSPSVQ+TLY + L +
Sbjct: 197 WRYH-------QCRDVDFEATWDTIRDVVLEKFAGPYDKGEYSPSVQKTLYDIQVVSLSQ 249
Query: 875 FADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSI 1015
++ + + +PNIH+ +++S ++ K++V LP D P+G I
Sbjct: 250 VPEIDDMEISLPNIHYFNIDMSKM---GLIN-KEEVLLPLDNPYGKI 292
>sp|Q3MHG7|URIC_BOVIN Uricase OS=Bos taurus GN=UOX PE=2 SV=3
Length = 304
Score = 167 bits (422), Expect = 2e-040
Identities = 102/287 (35%), Positives = 159/287 (55%), Gaps = 17/287 (5%)
Frame = +2
Query: 161 HGKARVRVGRVWRQGLDGSHHFV-EWNVSISLLSHCLSSYHRDDNSDIVATDTMKNTVYV 337
+GK V+V + R DG +H + E S+ L + Y DNSDI+ TDT+KNTV V
Sbjct: 21 YGKDMVKVLHIQR---DGKYHSIKEVATSVQLTLNSRREYLHGDNSDIIPTDTIKNTVQV 77
Query: 338 KAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLHGF-KLGS 514
AK G + S+E FA+ + HF S + V V + E PW+R +G H+H F +
Sbjct: 78 LAKFKGIK-SIETFAMNICEHFLSSFNHVIRVQVYVEEVPWKRFEKNGVKHVHAFIHTPT 136
Query: 515 ENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATEVNAS 694
H E +SG + SG+ L +LKTTQSGFE F++D++T LP+ ++R AT+V
Sbjct: 137 GTHFCEVEQLRSGPPVIHSGIKDLKVLKTTQSGFEGFLKDQFTTLPEVKDRCFATQVYCK 196
Query: 695 WRYSYESVASIPKKELYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMGGAVLRR 874
WRY +++ F + V+ +++ F GP + G YSPSVQ+TLY + L +
Sbjct: 197 WRYH-------QGRDVDFEATWEAVRGIVLKKFAGPYDKGEYSPSVQKTLYDIQVLSLSQ 249
Query: 875 FADVASIHLKMPNIHFLPVNLSSKENPSMVKFKDDVYLPTDEPHGSI 1015
++ + + +PNIH+ +++S ++ K++V LP D P+G I
Sbjct: 250 LPEIEDMEISLPNIHYFNIDMSKM---GLIN-KEEVLLPLDNPYGRI 292
>sp|Q54LT2|URIC_DICDI Uricase OS=Dictyostelium discoideum GN=uox PE=3 SV=1
Length = 287
Score = 136 bits (342), Expect = 4e-031
Identities = 83/192 (43%), Positives = 117/192 (60%), Gaps = 4/192 (2%)
Frame = +2
Query: 149 VDQRHGKARVRVGRVWRQGLDGSHHFVEWNVSISLLSHCLS-SYHRDDNSDIVATDTMKN 325
+D R+GKARVRV RV++ G + H +++ + L S +Y DNS +VATDTMKN
Sbjct: 5 IDNRYGKARVRVLRVFK-GPNEYHKVFDFDCRVLLRGAEFSETYLTGDNSKVVATDTMKN 63
Query: 326 TVYVKAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERV-CIDGKPHLHGF 502
TVYV A++ + S+EE+ ILLG HF + Y V V + E W R+ +GK H F
Sbjct: 64 TVYVIAQK-EEFKSLEEYGILLGKHFLATYSWVNGVEVVMRENQWRRIKTSNGKEQAHSF 122
Query: 503 KLGSENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATE 682
+ E H+V T + + + SG+ L ++KTTQSGFE F RDKYT L +T++R+ AT
Sbjct: 123 QRDREIHSVTVTSSRDKSPVVVSGIDDLLIMKTTQSGFEGFHRDKYTSLKETKDRVFATV 182
Query: 683 VNASWRYSYESV 718
V A+W Y+ SV
Sbjct: 183 VTANWTYNTLSV 194
>sp|P25688|URIC_MOUSE Uricase OS=Mus musculus GN=Uox PE=1 SV=2
Length = 303
Score = 123 bits (308), Expect = 3e-027
Identities = 74/188 (39%), Positives = 106/188 (56%), Gaps = 6/188 (3%)
Frame = +2
Query: 161 HGKARVRVGRVWRQGLDGSHHFV-EWNVSISLLSHCLSSYHRDDNSDIVATDTMKNTVYV 337
+GK V+V + R DG +H + E S+ L Y DNSDI+ TDT+KNTV+V
Sbjct: 21 YGKDMVKVLHIQR---DGKYHSIKEVATSVQLTLRSKKDYLHGDNSDIIPTDTIKNTVHV 77
Query: 338 KAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLHGF-KLGS 514
AK G R ++E FA+ + HF S + V A V + E PW+R +G H+H F +
Sbjct: 78 LAKLRGIR-NIETFAMNICEHFLSSFNHVTRAHVYVEEVPWKRFEKNGIKHVHAFIHTPT 136
Query: 515 ENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATEVNAS 694
H E ++G + SG+ L +LKTTQSGFE F++D++T LP+ ++R AT+V
Sbjct: 137 GTHFCEVEQMRNGPPVIHSGIKDLKVLKTTQSGFEGFLKDQFTTLPEVKDRCFATQVYCK 196
Query: 695 WRYSYESV 718
WRY V
Sbjct: 197 WRYQRRDV 204
>sp|P09118|URIC_RAT Uricase OS=Rattus norvegicus GN=Uox PE=1 SV=3
Length = 303
Score = 123 bits (307), Expect = 4e-027
Identities = 73/188 (38%), Positives = 106/188 (56%), Gaps = 6/188 (3%)
Frame = +2
Query: 161 HGKARVRVGRVWRQGLDGSHHFV-EWNVSISLLSHCLSSYHRDDNSDIVATDTMKNTVYV 337
+GK V+V + R DG +H + E S+ L Y DNSDI+ TDT+KNTV+V
Sbjct: 21 YGKDMVKVLHIQR---DGKYHSIKEVATSVQLTLRSKKDYLHGDNSDIIPTDTIKNTVHV 77
Query: 338 KAKECGDRLSVEEFAILLGNHFCSFYPQVYTAIVNIIEKPWERVCIDGKPHLHGF-KLGS 514
AK G + S+E FA+ + HF S + V A V + E PW+R +G H+H F +
Sbjct: 78 LAKFKGIK-SIETFAMNICEHFLSSFSHVTRAHVYVEEVPWKRFEKNGVKHVHAFIHTPT 136
Query: 515 ENHTVEATVHKSGALTLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATEVNAS 694
H + ++G + SG+ L +LKTTQSGFE F++D++T LP+ ++R AT+V
Sbjct: 137 GTHFCDVEQVRNGPPIIHSGIKDLKVLKTTQSGFEGFIKDQFTTLPEVKDRCFATQVYCK 196
Query: 695 WRYSYESV 718
WRY V
Sbjct: 197 WRYQNRDV 204
>sp|P22673|URIC_DROPS Uricase OS=Drosophila pseudoobscura pseudoobscura GN=Uro
PE=2 SV=2
Length = 346
Score = 108 bits (269), Expect = 1e-022
Identities = 61/158 (38%), Positives = 91/158 (57%), Gaps = 10/158 (6%)
Frame = +2
Query: 560 TLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATEVNASWRYSYESVASIPKKE 739
T+ +G+ GL +LKTTQS F FV D++ LPD +R+ +T V+ SW YS +
Sbjct: 190 TVITGIKGLRVLKTTQSSFVNFVNDEFRSLPDQYDRIFSTVVDCSWEYS-------DTET 242
Query: 740 LYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMGGAVLRRFADVASIHLKMPNIH 919
+ F+ + VK +++ F G P+ GV SPSVQ TLYL VL V+ I + MPN H
Sbjct: 243 VNFSRAWQTVKNIILRNFAGDPQVGVSSPSVQHTLYLSEKQVLDVIPQVSVISMTMPNKH 302
Query: 920 FLPVNLSSKENPSMVK-FKDDVYLPTDEPHGSIEATLS 1030
+ N +K +V ++V++P D+PHG+I A L+
Sbjct: 303 YF--NFDTKPFQKIVPGDNNEVFIPVDKPHGTIYAQLA 338
>sp|O44111|URIC_DROSU Uricase (Fragment) OS=Drosophila subobscura GN=Uro PE=2
SV=1
Length = 339
Score = 108 bits (268), Expect = 1e-022
Identities = 61/158 (38%), Positives = 90/158 (56%), Gaps = 10/158 (6%)
Frame = +2
Query: 560 TLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATEVNASWRYSYESVASIPKKE 739
T+ +G+ GL +LKTTQS F FV D+ LPD +R+ +T V+ SW YS +
Sbjct: 183 TVITGIKGLRVLKTTQSSFVNFVNDEXRSLPDQYDRIFSTVVDCSWEYSDTDTVN----- 237
Query: 740 LYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMGGAVLRRFADVASIHLKMPNIH 919
F+ + +VK +++ F G P+ GV SPSVQ TLYL VL V+ I + MPN H
Sbjct: 238 --FSRAWQQVKNIILRNFAGDPQVGVSSPSVQHTLYLSEKQVLDVIPQVSVISMTMPNKH 295
Query: 920 FLPVNLSSKENPSMVK-FKDDVYLPTDEPHGSIEATLS 1030
+ N +K +V ++V++P D+PHG+I A L+
Sbjct: 296 YF--NFDTKPFQQIVPGDNNEVFIPVDKPHGTIYAQLA 331
>sp|P16163|URIC_DROME Uricase OS=Drosophila melanogaster GN=Uro PE=1 SV=2
Length = 352
Score = 106 bits (263), Expect = 5e-022
Identities = 61/158 (38%), Positives = 89/158 (56%), Gaps = 10/158 (6%)
Frame = +2
Query: 560 TLTSGVAGLALLKTTQSGFEKFVRDKYTILPDTRERMLATEVNASWRYSYESVASIPKKE 739
T+ +G+ GL +LKTTQS F FV D++ LPD +R+ +T V+ SW YS +
Sbjct: 196 TVITGIKGLRVLKTTQSSFVNFVNDEFRSLPDQYDRIFSTVVDCSWEYS-------DTEN 248
Query: 740 LYFNEKFMEVKKVLMDTFFGPPETGVYSPSVQRTLYLMGGAVLRRFADVASIHLKMPNIH 919
L F + VK +++ F G P+ GV SPSVQ TLYL VL V+ I + MPN H
Sbjct: 249 LDFLRAWQTVKNIIIRNFAGDPQVGVSSPSVQHTLYLSERQVLDVLPQVSVISMTMPNKH 308
Query: 920 FLPVNLSSKENPSMVK-FKDDVYLPTDEPHGSIEATLS 1030
+ N +K + ++V++P D+PHG+I A L+
Sbjct: 309 YF--NFDTKPFQKIAPGDNNEVFIPVDKPHGTIYAQLA 344
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,771,599,260
Number of Sequences: 518415
Number of Extensions: 58771599260
Number of Successful Extensions: 389091298
Number of sequences better than 0.0: 0
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