BLASTX 7.6.2
Query= UN14173 /QuerySize=1832
(1831 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O15118|NPC1_HUMAN Niemann-Pick C1 protein OS=Homo sapiens GN=... 396 5e-109
sp|O35604|NPC1_MOUSE Niemann-Pick C1 protein OS=Mus musculus GN=... 395 6e-109
sp|Q6T3U3|NPCL1_RAT Niemann-Pick C1-like protein 1 OS=Rattus nor... 368 1e-100
sp|Q6T3U4|NPCL1_MOUSE Niemann-Pick C1-like protein 1 OS=Mus musc... 364 2e-099
sp|Q9UHC9|NPCL1_HUMAN Niemann-Pick C1-like protein 1 OS=Homo sap... 362 4e-099
sp|P56941|NPC1_PIG Niemann-Pick C1 protein OS=Sus scrofa GN=NPC1... 358 1e-097
sp|Q12200|NPC1_YEAST Niemann-Pick type C-related protein 1 OS=Sa... 193 6e-048
sp|Q61115|PTC1_MOUSE Protein patched homolog 1 OS=Mus musculus G... 149 8e-035
sp|Q90693|PTC1_CHICK Protein patched homolog 1 OS=Gallus gallus ... 149 1e-034
sp|Q13635|PTC1_HUMAN Protein patched homolog 1 OS=Homo sapiens G... 148 1e-034
sp|O35595|PTC2_MOUSE Protein patched homolog 2 OS=Mus musculus G... 148 1e-034
sp|Q98864|PTC1_DANRE Protein patched homolog 1 OS=Danio rerio GN... 146 5e-034
sp|Q9Y6C5|PTC2_HUMAN Protein patched homolog 2 OS=Homo sapiens G... 143 4e-033
sp|Q09614|PTC1_CAEEL Protein patched homolog 1 OS=Caenorhabditis... 124 3e-027
>sp|O15118|NPC1_HUMAN Niemann-Pick C1 protein OS=Homo sapiens GN=NPC1 PE=1 SV=2
Length = 1278
Score = 396 bits (1015), Expect = 5e-109
Identities = 218/523 (41%), Positives = 323/523 (61%), Gaps = 30/523 (5%)
Frame = +2
Query: 59 MPAVRVFSLFAALAVLLDFILQITAFVALIVFDFRRTEDKRVDCFPCIKRPQSSDGDNKG 238
MPAV FSLFA LAV +DF+LQIT FV+L+ D +R E R+D F C++ + DG +
Sbjct: 754 MPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVR--GAEDGTSV- 810
Query: 239 VGQKKPGPLTRYMKEVHAPILSHWAVKIVVIAFFFGLAMAGIALSTRIEPGLEQQIVLPQ 418
Q L R+ K ++P+L ++ +VIA F G+ IA+ +++ GL+Q + +P
Sbjct: 811 --QASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPD 868
Query: 419 DSYLHDYFNNIETYLRIGPPLYFVL-KNYNYSSESSQTNQLCSINKCDSNSLMNEIAKAS 595
DSY+ DYF +I YL GPP+YFVL + ++Y+S Q N +C C+++SL+ +I A+
Sbjct: 869 DSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQ-NMVCGGMGCNNDSLVQQIFNAA 927
Query: 596 LTPELSYIAKPAASWVDDFLVWLSPEAFGCCRKFTNGTFCPPDDQPPCCPADQGSCGLSE 775
+ I +SW+DD+ W+ P++ CCR N T DQ C S
Sbjct: 928 QLDNYTRIGFAPSSWIDDYFDWVKPQS-SCCR-VDNIT-----DQ---------FCNASV 971
Query: 776 VCKDCTTCFRHADLSSDRPSTVQFREKLPWFLSALPSADCAKGGHGAYSTSVDLQGYKNG 955
V C C RP F LP FLS P+ C KGGH AYS++V++
Sbjct: 972 VDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHGT 1031
Query: 956 IIQASSFRTYHTPLNKQADFVNSMRAAQEFSSKVSRSLKM-----EIYPYSVFYMFFEQY 1120
+ A+ F TYHT L ADF+++++ A+ +S V+ ++ + ++PYSVFY+F+EQY
Sbjct: 1032 RVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQY 1091
Query: 1121 LDIWKTALINLSIAIAAVFAVCLIIT-CSFWSSAIILLVIAMLIIDLLGVMAVFHIQLNA 1297
L I + NL +++ A+F V +++ C WS+ I+ IAM+++++ GVM ++ I LNA
Sbjct: 1092 LTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNA 1151
Query: 1298 LSVVNLIMSVGIAVEFCVHITHAFSTS-SGNRNQRMKEALGGMGASVFSGITLTKLVGVI 1474
+S+VNL+MS GI+VEFC HIT AF+ S G+R +R +EAL MG+SVFSGITLTK G++
Sbjct: 1152 VSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTKFGGIV 1211
Query: 1475 VLGFSKSEVFVVYYFKMYLALVLLGFLHGLVFLPVFLSMFGPA 1603
VL F+KS++F ++YF+MYLA+VLLG HGL+FLPV LS GP+
Sbjct: 1212 VLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPS 1254
>sp|O35604|NPC1_MOUSE Niemann-Pick C1 protein OS=Mus musculus GN=Npc1 PE=1 SV=1
Length = 1278
Score = 395 bits (1014), Expect = 6e-109
Identities = 210/523 (40%), Positives = 319/523 (60%), Gaps = 31/523 (5%)
Frame = +2
Query: 59 MPAVRVFSLFAALAVLLDFILQITAFVALIVFDFRRTEDKRVDCFPCIKRPQSSDGDNKG 238
MPAV FSLFA +AVL+DF+LQIT FV+L+ D +R E +D C++ G +
Sbjct: 755 MPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCVRGADDGQGSHAS 814
Query: 239 VGQKKPGPLTRYMKEVHAPILSHWAVKIVVIAFFFGLAMAGIALSTRIEPGLEQQIVLPQ 418
L R+ K AP+L ++ +V+A F G+ +A+ +++ GL+Q + +P
Sbjct: 815 ESY-----LFRFFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPN 869
Query: 419 DSYLHDYFNNIETYLRIGPPLYFVL-KNYNYSSESSQTNQLCSINKCDSNSLMNEIAKAS 595
DSY+ F ++ YL GPP+YFVL + YNYSS Q N +C CD++SL+ +I A+
Sbjct: 870 DSYVIANFKSLAQYLHSGPPVYFVLEEGYNYSSRKGQ-NMVCGGMGCDNDSLVQQIFNAA 928
Query: 596 LTPELSYIAKPAASWVDDFLVWLSPEAFGCCRKFTNGTFCPPDDQPPCCPADQGSCGLSE 775
+ + +SW+DD+ W+SP++ CCR + C S
Sbjct: 929 ELDTYTRVGFAPSSWIDDYFDWVSPQS-SCCRLYN---------------VTHQFCNASV 972
Query: 776 VCKDCTTCFRHADLSSDRPSTVQFREKLPWFLSALPSADCAKGGHGAYSTSVDLQGYKNG 955
+ C C RP +F + LP FLS P+ C KGGH AY ++V++ G +
Sbjct: 973 MDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPNPKCGKGGHAAYGSAVNIVG-DDT 1031
Query: 956 IIQASSFRTYHTPLNKQADFVNSMRAAQEFSSKVSRSLKME-----IYPYSVFYMFFEQY 1120
I A+ F TYHT L AD+ ++M+ A+ +S ++ +++ + ++PYSVFY+F+EQY
Sbjct: 1032 YIGATYFMTYHTILKTSADYTDAMKKARLIASNITETMRSKGSDYRVFPYSVFYVFYEQY 1091
Query: 1121 LDIWKTALINLSIAIAAVFAVCLIIT-CSFWSSAIILLVIAMLIIDLLGVMAVFHIQLNA 1297
L I + NLS+++ ++F V L++ C WS+ I+ + IAM+++++ GVM ++ I LNA
Sbjct: 1092 LTIIDDTIFNLSVSLGSIFLVTLVVLGCELWSAVIMCITIAMILVNMFGVMWLWGISLNA 1151
Query: 1298 LSVVNLIMSVGIAVEFCVHITHAFSTSS-GNRNQRMKEALGGMGASVFSGITLTKLVGVI 1474
+S+VNL+MS GI+VEFC HIT AF+ S+ G+R R +EAL MG+SVFSGITLTK G++
Sbjct: 1152 VSLVNLVMSCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITLTKFGGIV 1211
Query: 1475 VLGFSKSEVFVVYYFKMYLALVLLGFLHGLVFLPVFLSMFGPA 1603
VL F+KS++F ++YF+MYLA+VLLG HGL+FLPV LS GP+
Sbjct: 1212 VLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPS 1254
>sp|Q6T3U3|NPCL1_RAT Niemann-Pick C1-like protein 1 OS=Rattus norvegicus
GN=Npc1l1 PE=1 SV=1
Length = 1331
Score = 368 bits (943), Expect = 1e-100
Identities = 212/556 (38%), Positives = 323/556 (58%), Gaps = 46/556 (8%)
Frame = +2
Query: 59 MPAVRVFSLFAALAVLLDFILQITAFVALIVFDFRRTEDKRVD---CFPCIKRPQSSDGD 229
MPAVR F+L + LA++LDF+LQ+TAFVAL+ D +R E R D CF K P
Sbjct: 766 MPAVRTFALTSGLAIILDFLLQMTAFVALLSLDSKRQEASRPDVLCCFSTRKLPPP---- 821
Query: 230 NKGVGQKKPGPLTRYMKEVHAPILSHWAVKIVVIAFFFGLAMAGIALSTRIEPGLEQQIV 409
++K G L R+ ++++AP L H ++ VV+ F L A + L I GL+Q++
Sbjct: 822 -----KEKEGLLLRFFRKIYAPFLLHRFIRPVVMLLFLTLFGANLYLMCNINVGLDQELA 876
Query: 410 LPQDSYLHDYFNNIETYLRIGPPLYFV-LKNYNYSSESSQTNQLCSINKCDSNSLMNEIA 586
LP+DSYL DYF + YL +GPP+YFV +N+SSE+ N CS C S SL +I
Sbjct: 877 LPKDSYLIDYFLFLNRYLEVGPPVYFVTTSGFNFSSEAGM-NATCSSAGCKSFSLTQKIQ 935
Query: 587 KASLTPELSYIAKPAASWVDDFLVWLSPEAFGCCRKFTNGTFCPPDDQPPCCPADQGSCG 766
AS P+ SY+A A+SWVDDF+ WL+P + CCR + G P D+ CP+ S
Sbjct: 936 YASEFPDQSYVAIAASSWVDDFIDWLTPSS-SCCRLYIRG---PHKDE--FCPSTDTSFN 989
Query: 767 LSEVCKDCTTCFRHADLSSDRPSTVQFREKLPWFLSALPSADCAKGGHGAYSTSVDLQGY 946
+ C + T L RP+ QF + LPWFL+ P+ C KGG AY TSV+L
Sbjct: 990 CLKNCMNRT-------LGPVRPTAEQFHKYLPWFLNDPPNIRCPKGGLAAYRTSVNLS-- 1040
Query: 947 KNGIIQASSFRTYHTPLNKQADFVNSMRAAQEFSSKVSRSLK--------MEIYPYSVFY 1102
+G + AS F YH PL DF ++RA++ ++ ++ L+ E++PY++
Sbjct: 1041 SDGQVIASQFMAYHKPLRNSQDFTEALRASRLLAANITADLRKVPGTDPNFEVFPYTISN 1100
Query: 1103 MFFEQYLDIWKTALINLSIAIAAVFAVC-LIITCSFWSSAIILLVIAMLIIDLLGVMAVF 1279
+F++QYL + + L++ F VC L++ S + LL I M+++D +G+MAV+
Sbjct: 1101 VFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDMCSGILNLLSIIMILVDTIGLMAVW 1160
Query: 1280 HIQLNALSVVNLIMSVGIAVEFCVHITHAFSTSS-GNRNQRMKEALGGMGASVFSGITLT 1456
I NA+S++NL+ +VG++VEF HIT +F+ S+ R +R K+A MG++VF+G+ +T
Sbjct: 1161 GISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATVFMGSAVFAGVAMT 1220
Query: 1457 KLVGVIVLGFSKSEVFVVYYFKMYLALVLLGFLHGLVFLPVFLSMFGP-------APRHV 1615
G+++LGF+++++ +++F++ L + LLG LHGLVFLPV LS GP +
Sbjct: 1221 NFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVQEEKL 1280
Query: 1616 AGDNKQDPQPSVSSLP 1663
A + P+PS P
Sbjct: 1281 ASEAAVAPEPSCPQYP 1296
>sp|Q6T3U4|NPCL1_MOUSE Niemann-Pick C1-like protein 1 OS=Mus musculus GN=Npc1l1
PE=2 SV=1
Length = 1333
Score = 364 bits (933), Expect = 2e-099
Identities = 204/525 (38%), Positives = 311/525 (59%), Gaps = 33/525 (6%)
Frame = +2
Query: 59 MPAVRVFSLFAALAVLLDFILQITAFVALIVFDFRRTEDKRVDCFPCIKRPQSSDGDNKG 238
MPAVR F+L + LA++ DF+LQ+TAFVAL+ D +R E R D C N
Sbjct: 766 MPAVRTFALTSGLAIIFDFLLQMTAFVALLSLDSKRQEASRPDVVCCF------SSRNLP 819
Query: 239 VGQKKPGPLTRYMKEVHAPILSHWAVKIVVIAFFFGLAMAGIALSTRIEPGLEQQIVLPQ 418
++K G L + ++++ P L H ++ VV+ F L A + L I GL+Q + LP+
Sbjct: 820 PPKQKEGLLLCFFRKIYTPFLLHRFIRPVVLLLFLVLFGANLYLMCNISVGLDQDLALPK 879
Query: 419 DSYLHDYFNNIETYLRIGPPLYF-VLKNYNYSSESSQTNQLCSINKCDSNSLMNEIAKAS 595
DSYL DYF + YL +GPP+YF YN+S+E+ N +CS C+S SL +I AS
Sbjct: 880 DSYLIDYFLFLNRYLEVGPPVYFDTTSGYNFSTEAGM-NAICSSAGCESFSLTQKIQYAS 938
Query: 596 LTPELSYIAKPAASWVDDFLVWLSPEAFGCCRKFTNGTFCPPDDQPPCCPADQGSCGLSE 775
P SY+A A+SWVDDF+ WL+P + CCR +T G P D+ CP+ S +
Sbjct: 939 EFPNQSYVAIAASSWVDDFIDWLTPSS-SCCRIYTRG---PHKDE--FCPSTDTSFNCLK 992
Query: 776 VCKDCTTCFRHADLSSDRPSTVQFREKLPWFLSALPSADCAKGGHGAYSTSVDLQGYKNG 955
C + T L RP+T QF + LPWFL+ P+ C KGG AY TSV+L +G
Sbjct: 993 NCMNRT-------LGPVRPTTEQFHKYLPWFLNDTPNIRCPKGGLAAYRTSVNLS--SDG 1043
Query: 956 IIQASSFRTYHTPLNKQADFVNSMRAAQEFSSKVSRSLK--------MEIYPYSVFYMFF 1111
I AS F YH PL DF ++RA++ ++ ++ L+ E++PY++ +F+
Sbjct: 1044 QIIASQFMAYHKPLRNSQDFTEALRASRLLAANITAELRKVPGTDPNFEVFPYTISNVFY 1103
Query: 1112 EQYLDIWKTALINLSIAIAAVFAVC-LIITCSFWSSAIILLVIAMLIIDLLGVMAVFHIQ 1288
+QYL + + L++ F VC L++ S + LL I M+++D +G+MAV+ I
Sbjct: 1104 QQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDIRSGILNLLSIIMILVDTIGLMAVWGIS 1163
Query: 1289 LNALSVVNLIMSVGIAVEFCVHITHAFSTSS-GNRNQRMKEALGGMGASVFSGITLTKLV 1465
NA+S++NL+ +VG++VEF HIT +F+ S+ R +R K+A MG++VF+G+ +T
Sbjct: 1164 YNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATIFMGSAVFAGVAMTNFP 1223
Query: 1466 GVIVLGFSKSEVFVVYYFKMYLALVLLGFLHGLVFLPVFLSMFGP 1600
G+++LGF+++++ +++F++ L + LLG LHGLVFLPV LS GP
Sbjct: 1224 GILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGP 1268
>sp|Q9UHC9|NPCL1_HUMAN Niemann-Pick C1-like protein 1 OS=Homo sapiens GN=NPC1L1
PE=2 SV=1
Length = 1359
Score = 362 bits (929), Expect = 4e-099
Identities = 213/550 (38%), Positives = 314/550 (57%), Gaps = 57/550 (10%)
Frame = +2
Query: 59 MPAVRVFSLFAALAVLLDFILQITAFVALIVFDFRRTEDKRVDCFPCIKRPQSSDGDNKG 238
MPAVR F+L + LAV+LDF+LQ++AFVAL+ D +R E R+D C+K PQ +G
Sbjct: 766 MPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVK-PQELPPPGQG 824
Query: 239 VGQKKPGPLTRYMKEVHAPILSHWAVKIVVIAFFFGLAMAGIALSTRIEPGLEQQIVLPQ 418
G L + ++ +AP L HW + VV+ F L + I GL+Q++ LP+
Sbjct: 825 -----EGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPK 879
Query: 419 DSYLHDYFNNIETYLRIGPPLYFVLK-NYNYSSESSQTNQLCSINKCDSNSLMNEIAKAS 595
DSYL DYF + Y +G P+YFV YN+SSE+ N +CS C++ S +I A+
Sbjct: 880 DSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGM-NAICSSAGCNNFSFTQKIQYAT 938
Query: 596 LTPELSYIAKPAASWVDDFLVWLSPEAFGCCRKFTNGTFCPPDDQPPCCPADQGSCGLSE 775
PE SY+A PA+SWVDDF+ WL+P + CCR + +G P D+ CP+ S +
Sbjct: 939 EFPEQSYLAIPASSWVDDFIDWLTPSS--CCRLYISG---PNKDK--FCPSTVNSLNCLK 991
Query: 776 VCKDCTTCFRHADLSSDRPSTVQFREKLPWFLSALPSADCAKGGHGAYSTSVDLQG---- 943
C T + S RPS QF + LPWFL+ P+ C KGG AYSTSV+L
Sbjct: 992 NCMSIT-------MGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQV 1044
Query: 944 ------------YKNGII---------QASSFRTYHTPLNKQADFVNSMRAAQEFSSKVS 1060
Y I AS F YH PL D+ ++RAA+E ++ ++
Sbjct: 1045 LDTVAILSPRLEYSGTISAHCNLYLLDSASRFMAYHKPLKNSQDYTEALRAARELAANIT 1104
Query: 1061 RSLK--------MEIYPYSVFYMFFEQYLDIWKTALINLSIAIAAVFAV-CLIITCSFWS 1213
L+ E++PY++ +F+EQYL I L LS+ + FAV CL++ S
Sbjct: 1105 ADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRS 1164
Query: 1214 SAIILLVIAMLIIDLLGVMAVFHIQLNALSVVNLIMSVGIAVEFCVHITHAFSTSS-GNR 1390
+ LL I M+++D +G MA++ I NA+S++NL+ +VG++VEF HIT +F+ S+
Sbjct: 1165 GLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTW 1224
Query: 1391 NQRMKEALGGMGASVFSGITLTKLVGVIVLGFSKSEVFVVYYFKMYLALVLLGFLHGLVF 1570
+R KEA MG++VF+G+ +T L G++VLG +K+++ +++F++ L + LLG LHGLVF
Sbjct: 1225 LERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVF 1284
Query: 1571 LPVFLSMFGP 1600
LPV LS GP
Sbjct: 1285 LPVILSYVGP 1294
>sp|P56941|NPC1_PIG Niemann-Pick C1 protein OS=Sus scrofa GN=NPC1 PE=2 SV=1
Length = 1277
Score = 358 bits (917), Expect = 1e-097
Identities = 192/467 (41%), Positives = 292/467 (62%), Gaps = 27/467 (5%)
Frame = +2
Query: 227 DNKGVGQKKPGPLTRYMKEVHAPILSHWAVKIVVIAFFFGLAMAGIALSTRIEPGLEQQI 406
D GV Q L R+ K +AP+L ++ +VIA F G+ IA+ ++E GL+Q +
Sbjct: 806 DGAGV-QASESCLFRFFKNSYAPLLLKDWMRPIVIAVFVGVLSFSIAVLNKVEIGLDQSL 864
Query: 407 VLPQDSYLHDYFNNIETYLRIGPPLYFVL-KNYNYSSESSQTNQLCSINKCDSNSLMNEI 583
+P DSY+ DYF ++ YL GPP+YFV+ + +NY+S Q N +C C+++SL+ +I
Sbjct: 865 SMPDDSYVMDYFQSLSRYLHAGPPVYFVVEEGHNYTSLKGQ-NMVCGGLGCNNDSLVQQI 923
Query: 584 AKASLTPELSYIAKPAASWVDDFLVWLSPEAFGCCRKFTNGTFCPPDDQPPCCPADQGSC 763
A+ + I +SW+DD+ W+ P++ CCR + + DQ C
Sbjct: 924 FTAAQLDNYTRIGFAPSSWIDDYFDWIKPQS-SCCRVYNS--------------TDQ-FC 967
Query: 764 GLSEVCKDCTTCFRHADLSSDRPSTVQFREKLPWFLSALPSADCAKGGHGAYSTSVDLQG 943
S V C C RP F LP FLS P+ C KGGH AYS++V++ G
Sbjct: 968 NASVVDPTCIRCRPLTSEGKQRPQGEDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILG 1027
Query: 944 YKNGIIQASSFRTYHTPLNKQADFVNSMRAAQEFSSKVSRSLKME-----IYPYSVFYMF 1108
+G + A+ F TYHT L ADF+++M+ A+ +S ++R++ +E ++PYSVFY+F
Sbjct: 1028 NGSG-VGATYFMTYHTVLQASADFIDAMQKARLIASNITRTMGLEASSYRVFPYSVFYVF 1086
Query: 1109 FEQYLDIWKTALINLSIAIAAVFAVCLIIT-CSFWSSAIILLVIAMLIIDLLGVMAVFHI 1285
+EQYL + + NL +++ A+F V +++ C W++ I+ + IAM+++++ GVM ++ I
Sbjct: 1087 YEQYLTVIDDTIFNLGVSLGAIFLVTVVLMGCELWATVIMCVTIAMILVNMFGVMWLWGI 1146
Query: 1286 QLNALSVVNLIMSVGIAVEFCVHITHAFSTSS-GNRNQRMKEALGGMGASVFSGITLTKL 1462
LNA+S+VNL+MS GI+VEFC HIT AF+ S+ G+R R +EAL MG+SVFSGITLTK
Sbjct: 1147 SLNAVSLVNLVMSCGISVEFCSHITRAFTLSTKGSRVDRAEEALAHMGSSVFSGITLTKF 1206
Query: 1463 VGVIVLGFSKSEVFVVYYFKMYLALVLLGFLHGLVFLPVFLSMFGPA 1603
G++VL F+KS++F ++YF+MYLA+VLLG HGL+FLPV LS GP+
Sbjct: 1207 GGIVVLAFAKSQIFQIFYFRMYLAIVLLGATHGLIFLPVLLSYIGPS 1253
>sp|Q12200|NPC1_YEAST Niemann-Pick type C-related protein 1 OS=Saccharomyces
cerevisiae GN=NCR1 PE=1 SV=1
Length = 1170
Score = 193 bits (488), Expect = 6e-048
Identities = 115/304 (37%), Positives = 172/304 (56%), Gaps = 19/304 (6%)
Frame = +2
Query: 716 PPDDQPPCCPADQGS---CGLSEVCKDCTTCFRHADLS---SDRPSTVQFREKLPWFLSA 877
P +DQ CC +G+ C S + C TCF+ + S P F E L +++A
Sbjct: 863 PQNDQ--CCRLKKGTDEVCPPSFPSRRCETCFQQGSWNYNMSGFPEGKDFMEYLSIWINA 920
Query: 878 LPSADCAKGGHGAYSTSVDLQGYKNGIIQASSFRTYHTPLNKQADFVNSMRAAQEFSSKV 1057
PS C GG YST++ Y + AS FRT H PL Q DF+ + SS
Sbjct: 921 -PSDPCPLGGRAPYSTAL---VYNETSVSASVFRTAHHPLRSQKDFIQAYSDGVRISSSF 976
Query: 1058 SRSLKMEIYPYSVFYMFFEQYLDIWKTALINLSIAIAAVFAVCLIITCSFWSSAIILLVI 1237
+++++ YS FY+FF QY + L + AI +F + + + SS ++ LV+
Sbjct: 977 P---ELDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIFFISSVFLQNIRSSFLLALVV 1033
Query: 1238 AMLIIDLLGVMAVFHIQLNALSVVNLIMSVGIAVEFCVHITHAF----STSSGNRNQRMK 1405
M+I+D+ +MA+ I LNA+S+VNLI+ VG+ VEFCVHI +F S + + N R+
Sbjct: 1034 TMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVVPSETKKDANSRVL 1093
Query: 1406 EALGGMGASVFSGITLTKLVGVIVLGFSKSEVFVVYYFKMYLALVLLGFLHGLVFLPVFL 1585
+L +G SV GITLTK +GV VL F++S++F V+YF+M+ L+++ LH L+FLP L
Sbjct: 1094 YSLNTIGESVIKGITLTKFIGVCVLAFAQSKIFDVFYFRMWFTLIIVAALHALLFLPALL 1153
Query: 1586 SMFG 1597
S+FG
Sbjct: 1154 SLFG 1157
Score = 91 bits (223), Expect = 3e-017
Identities = 45/136 (33%), Positives = 74/136 (54%), Gaps = 4/136 (2%)
Frame = +2
Query: 317 KIVVIAFFFGLAMAGIALSTRIEPGLEQQIVLPQDSYLHDYFNNIETYLRIGPPLYFVLK 496
K ++I F + I+ GL+Q + +PQDSYL DYF ++ ++L +GPP+Y V+K
Sbjct: 749 KRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVK 808
Query: 497 NYNYSSESSQTNQLCSINKCDSNSLMNEIAKASLTPELSYIAKPAASWVDDFLVWLSPEA 676
N + + +Q C+ +SL N + + S I +P A+W+DD+ ++L+P+
Sbjct: 809 NLDLTKRQNQQKICGKFTTCERDSLANVLEQER---HRSTITEPLANWLDDYFMFLNPQN 865
Query: 677 FGCCR-KFTNGTFCPP 721
CCR K CPP
Sbjct: 866 DQCCRLKKGTDEVCPP 881
>sp|Q61115|PTC1_MOUSE Protein patched homolog 1 OS=Mus musculus GN=Ptch1 PE=2
SV=1
Length = 1434
Score = 149 bits (375), Expect = 8e-035
Identities = 87/235 (37%), Positives = 138/235 (58%), Gaps = 3/235 (1%)
Frame = +2
Query: 959 IQASSFRTYHTPLNKQADFVNSMRAAQEFSSKVSRSLKMEIYPYSVFYMFFEQYLDIWKT 1138
I+ + F Y L +DFV ++ + + + SL + YP ++F+EQY+ +
Sbjct: 955 IEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYT-SLGLSSYPNGYPFLFWEQYISLRHW 1013
Query: 1139 ALINLSIAIAAVFAVCLIITCSFWSSAIILLVIAMLIIDLLGVMAVFHIQLNALSVVNLI 1318
L+++S+ +A F VC + + W++ II++V+A++ ++L G+M + I+L+A+ VV LI
Sbjct: 1014 LLLSISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 1073
Query: 1319 MSVGIAVEFCVHITHAFSTSSGNRNQRMKEALGGMGASVFSGITLTKLVGVIVLGFSKSE 1498
SVGI VEF VH+ AF T+ G++N R AL M A V G T L+GV++L S+ +
Sbjct: 1074 ASVGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVST-LLGVLMLAGSEFD 1132
Query: 1499 VFVVYYFKMYLALVLLGFLHGLVFLPVFLSMFGPAPRHVAGDNKQDPQPSVSSLP 1663
V Y+F + L +LG L+GLV LPV LS FGP P V+ N + P+ S P
Sbjct: 1133 FIVRYFFAVLAILTVLGVLNGLVLLPVLLSFFGPCP-EVSPANGLNRLPTPSPEP 1186
>sp|Q90693|PTC1_CHICK Protein patched homolog 1 OS=Gallus gallus GN=PTCH1 PE=1
SV=1
Length = 1442
Score = 149 bits (374), Expect = 1e-034
Identities = 88/238 (36%), Positives = 140/238 (58%), Gaps = 9/238 (3%)
Frame = +2
Query: 959 IQASSFRTYHTPLNKQADFVNSMRAAQEFSSKVSRSLKMEIYPYSVFYMFFEQYLDIWKT 1138
I+ + F Y L + +DFV ++ + + + SL + YP ++F+EQY+ +
Sbjct: 968 IEYAQFPFYLNGLRETSDFVEAIEKVRAICNNYT-SLGIASYPNGYPFLFWEQYIGLRHW 1026
Query: 1139 ALINLSIAIAAVFAVCLIITCSFWSSAIILLVIAMLIIDLLGVMAVFHIQLNALSVVNLI 1318
L+++S+ +A F VC + + W++ II++V+A++ ++L G+M + I+L+A+ VV LI
Sbjct: 1027 LLLSISVVLACTFLVCALFLLNPWTAGIIVVVLALMTVELFGMMGLIGIKLSAVPVVILI 1086
Query: 1319 MSVGIAVEFCVHITHAFSTSSGNRNQRMKEALGGMGASVFSGITLTKLVGVIVLGFSKSE 1498
SVGI VEF VHI AF T+ G++N+R AL M A V G T L+GV++L S+ +
Sbjct: 1087 ASVGIGVEFTVHIALAFLTAIGDKNRRAVLALEHMFAPVLDGAVST-LLGVLMLAGSEFD 1145
Query: 1499 VFVVYYFKMYLALVLLGFLHGLVFLPVFLSMFGPAPR--HVAGDNK-----QDPQPSV 1651
V Y+F + L +LG L+GLV LPV LS FGP P G N+ +P PS+
Sbjct: 1146 FIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPACGRNRLPTPSPEPPPSI 1203
>sp|Q13635|PTC1_HUMAN Protein patched homolog 1 OS=Homo sapiens GN=PTCH1 PE=1
SV=2
Length = 1447
Score = 148 bits (373), Expect = 1e-034
Identities = 88/235 (37%), Positives = 138/235 (58%), Gaps = 3/235 (1%)
Frame = +2
Query: 959 IQASSFRTYHTPLNKQADFVNSMRAAQEFSSKVSRSLKMEIYPYSVFYMFFEQYLDIWKT 1138
I+ + F Y L +DFV ++ + S + SL + YP ++F+EQY+ +
Sbjct: 969 IEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSSYPNGYPFLFWEQYIGLRHW 1027
Query: 1139 ALINLSIAIAAVFAVCLIITCSFWSSAIILLVIAMLIIDLLGVMAVFHIQLNALSVVNLI 1318
L+ +S+ +A F VC + + W++ II++V+A++ ++L G+M + I+L+A+ VV LI
Sbjct: 1028 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 1087
Query: 1319 MSVGIAVEFCVHITHAFSTSSGNRNQRMKEALGGMGASVFSGITLTKLVGVIVLGFSKSE 1498
SVGI VEF VH+ AF T+ G++N+R AL M A V G T L+GV++L S+ +
Sbjct: 1088 ASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVST-LLGVLMLAGSEFD 1146
Query: 1499 VFVVYYFKMYLALVLLGFLHGLVFLPVFLSMFGPAPRHVAGDNKQDPQPSVSSLP 1663
V Y+F + L +LG L+GLV LPV LS FGP P V+ N + P+ S P
Sbjct: 1147 FIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYP-EVSPANGLNRLPTPSPEP 1200
>sp|O35595|PTC2_MOUSE Protein patched homolog 2 OS=Mus musculus GN=Ptch2 PE=2
SV=2
Length = 1182
Score = 148 bits (373), Expect = 1e-034
Identities = 85/225 (37%), Positives = 132/225 (58%), Gaps = 3/225 (1%)
Frame = +2
Query: 995 LNKQADFVNSMRAAQEFSSKVSRSLKMEIYPYSVFYMFFEQYLDIWKTALINLSIAIAAV 1174
L K ADFV ++ A+ ++ ++ + YP ++F+EQYL + + L+ + I +
Sbjct: 917 LQKTADFVEAIEGARAACTEAGQA-GVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCT 975
Query: 1175 FAVCLIITCSFWSSAIILLVIAMLIIDLLGVMAVFHIQLNALSVVNLIMSVGIAVEFCVH 1354
F VC ++ S W++ +I+LV+AM+ ++L G+M I+L+A+ VV L+ S+GI VEF VH
Sbjct: 976 FLVCALLLLSPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASIGIGVEFTVH 1035
Query: 1355 ITHAFSTSSGNRNQRMKEALGGMGASVFSGITLTKLVGVIVLGFSKSEVFVVYYFKMYLA 1534
+ F TS G+RN R AL A V G T L+G+++L S + + Y+F +
Sbjct: 1036 VALGFLTSHGSRNLRAASALEQTFAPVTDGAVST-LLGLLMLAGSNFDFIIRYFFVVLTV 1094
Query: 1535 LVLLGFLHGLVFLPVFLSMFGPAPRHVAGDNKQDPQPSVSSLP*R 1669
L LLG LHGL+ LPV LS+ GP P+ V K+ PQ S+ P R
Sbjct: 1095 LTLLGLLHGLLLLPVLLSILGPPPQ-VVQVYKESPQTLNSAAPQR 1138
>sp|Q98864|PTC1_DANRE Protein patched homolog 1 OS=Danio rerio GN=ptch1 PE=2
SV=1
Length = 1220
Score = 146 bits (368), Expect = 5e-034
Identities = 82/240 (34%), Positives = 139/240 (57%), Gaps = 3/240 (1%)
Frame = +2
Query: 959 IQASSFRTYHTPLNKQADFVNSMRAAQEFSSKVSRSLKMEIYPYSVFYMFFEQYLDIWKT 1138
++ + F Y L + +DF+ ++ + + + R ++ YP ++F+EQY+ +
Sbjct: 958 LEFAQFPFYLNGLRQASDFIEAIESVRTICEEFMRQ-GIKNYPNGYPFLFWEQYIGLRHW 1016
Query: 1139 ALINLSIAIAAVFAVCLIITCSFWSSAIILLVIAMLIIDLLGVMAVFHIQLNALSVVNLI 1318
L+++S+ +A F VC I+ + W++ +I+ ++ M+ ++L G+M + I+L+A+ VV LI
Sbjct: 1017 FLLSISVVLACTFLVCAILLLNPWTAGVIVFILPMMTVELFGIMGLIGIKLSAIPVVILI 1076
Query: 1319 MSVGIAVEFCVHITHAFSTSSGNRNQRMKEALGGMGASVFSGITLTKLVGVIVLGFSKSE 1498
SVGI VEF VHI F T+ G+RN R A+ M A V G ++ L+GV++L S+ +
Sbjct: 1077 ASVGIGVEFTVHIALGFLTAIGDRNTRSAVAMEHMFAPVIDG-AISTLLGVLMLAGSEFD 1135
Query: 1499 VFVVYYFKMYLALVLLGFLHGLVFLPVFLSMFGPAPRHVAGDNKQDPQ-PSVSSLP*RLN 1675
+ Y+F + L LLG L+GLV LPV LS+ GP V +N Q PS +P +N
Sbjct: 1136 FIMRYFFAVLAILTLLGILNGLVLLPVLLSLMGPPAEVVPANNANHLQSPSPEPMPPPMN 1195
>sp|Q9Y6C5|PTC2_HUMAN Protein patched homolog 2 OS=Homo sapiens GN=PTCH2 PE=2
SV=2
Length = 1203
Score = 143 bits (360), Expect = 4e-033
Identities = 78/204 (38%), Positives = 122/204 (59%), Gaps = 2/204 (0%)
Frame = +2
Query: 995 LNKQADFVNSMRAAQEFSSKVSRSLKMEIYPYSVFYMFFEQYLDIWKTALINLSIAIAAV 1174
L K ADFV ++ A+ ++ ++ + YP ++F+EQYL + + L+ + I +
Sbjct: 917 LQKTADFVEAIEGARAACAEAGQA-GVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCT 975
Query: 1175 FAVCLIITCSFWSSAIILLVIAMLIIDLLGVMAVFHIQLNALSVVNLIMSVGIAVEFCVH 1354
F VC ++ + W++ +I+LV+AM+ ++L G+M I+L+A+ VV L+ SVGI VEF VH
Sbjct: 976 FLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVH 1035
Query: 1355 ITHAFSTSSGNRNQRMKEALGGMGASVFSGITLTKLVGVIVLGFSKSEVFVVYYFKMYLA 1534
+ F T+ G+RN R AL A V G ++ L+G+++L S + V Y+F
Sbjct: 1036 VALGFLTTQGSRNLRAAHALEHTFAPVTDG-AISTLLGLLMLAGSHFDFIVRYFFAALTV 1094
Query: 1535 LVLLGFLHGLVFLPVFLSMFGPAP 1606
L LLG LHGLV LPV LS+ GP P
Sbjct: 1095 LTLLGLLHGLVLLPVLLSILGPPP 1118
>sp|Q09614|PTC1_CAEEL Protein patched homolog 1 OS=Caenorhabditis elegans
GN=ptc-1 PE=1 SV=2
Length = 1408
Score = 124 bits (310), Expect = 3e-027
Identities = 62/173 (35%), Positives = 107/173 (61%), Gaps = 1/173 (0%)
Frame = +2
Query: 1082 YPYSVFYMFFEQYLDIWKTALINLSIAIAAVFAVCLIITCSFWSSAIILLVIAMLIIDLL 1261
+P + + F+EQYL + + +SI +VF V ++ + W++ +++ ++ ++ +L
Sbjct: 1164 FPQGIAFTFWEQYLFLTGNLMQAISIITISVFCVISVLLFNPWAALMVVCILGIMTCELA 1223
Query: 1262 GVMAVFHIQLNALSVVNLIMSVGIAVEFCVHITHAFSTSSGNRNQRMKEALGGMGASVFS 1441
G M + I+LN +S V LI +VGI VEF VH+ +F T+ G R+QR A+ + V
Sbjct: 1224 GFMGLVGIKLNPVSAVTLITAVGIGVEFTVHVVVSFLTALGTRSQRTSSAVDRVFVPVIH 1283
Query: 1442 GITLTKLVGVIVLGFSKSEVFVVYYFKMYLALVLLGFLHGLVFLPVFLSMFGP 1600
G + + L+G+++LGFS+ E V Y+F + AL+ +G ++GL+ LPV LS FGP
Sbjct: 1284 G-SFSTLLGILMLGFSEFEFVVKYFFIVMTALICIGIINGLILLPVLLSWFGP 1335
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,771,599,260
Number of Sequences: 518415
Number of Extensions: 58771599260
Number of Successful Extensions: 389091298
Number of sequences better than 0.0: 0
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