BLASTX 7.6.2
Query= UN14209 /QuerySize=1538
(1537 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q2TCH3|ACLY_SHEEP ATP-citrate synthase OS=Ovis aries GN=ACLY ... 347 1e-094
sp|Q32PF2|ACLY_BOVIN ATP-citrate synthase OS=Bos taurus GN=ACLY ... 347 2e-094
sp|P53396|ACLY_HUMAN ATP-citrate synthase OS=Homo sapiens GN=ACL... 347 2e-094
sp|Q91V92|ACLY_MOUSE ATP-citrate synthase OS=Mus musculus GN=Acl... 347 2e-094
sp|P16638|ACLY_RAT ATP-citrate synthase OS=Rattus norvegicus GN=... 347 2e-094
sp|P53585|ACLY_CAEEL Probable ATP-citrate synthase OS=Caenorhabd... 201 1e-050
sp|O13907|ACL2_SCHPO Probable ATP-citrate synthase subunit 2 OS=... 192 8e-048
>sp|Q2TCH3|ACLY_SHEEP ATP-citrate synthase OS=Ovis aries GN=ACLY PE=2 SV=1
Length = 1101
Score = 347 bits (890), Expect = 1e-094
Identities = 189/421 (44%), Positives = 258/421 (61%), Gaps = 7/421 (1%)
Frame = -1
Query: 1447 MARKKIREYDSKRLVKEHFKRLSGKELPIRSVQINQETDLNELVEKEPWLSSEKLVVKPD 1268
M+ K I E K L+ ++ S + + ++ +TD L++ PWL S+ LVVKPD
Sbjct: 1 MSAKAISEQTGKELLYKYICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQSLVVKPD 60
Query: 1267 MLFGKRGKSGLVALKLDFAEVATFVKERLGKEVEMSGCKGPITTFIVEPFVPH--NEEFY 1094
L +RGK GLV + L V +++K RLG+E + G + F++EPFVPH EEFY
Sbjct: 61 QLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHTQEEEFY 120
Query: 1093 LNIVSDRLGCSISFSECGGIDIEENWDKVKTISVPTGSSLTPE-ICAPLVATLPLEIKGE 917
+ I + R G + F GG+D+ + K + + V L PE I L+ P + K
Sbjct: 121 VCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVAVDEKLNPEDIKKHLLVHAPEDKKEI 180
Query: 916 LEDFIQVIFTLFQDLDFTFLEMNPFALVDGKPYPLDMRGELDDTAAFKNFKKWGDIEFPM 737
L FI +F ++DL FT+LE+NP + Y LD+ ++D TA + KWGDIEFP
Sbjct: 181 LASFISGLFNFYEDLYFTYLEINPLVVTKDGVYILDLAAKVDATADYICKVKWGDIEFPP 240
Query: 736 PFGRVMSPTESFIHGLDEKTSASLKFTVLNPKGRIWTMVAGGGASVIYADTVGDLGYASE 557
PFGR P E++I LD K+ ASLK T+LNPKGRIWTMVAGGGASV+Y+DT+ DLG +E
Sbjct: 241 PFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNE 300
Query: 556 LGNYAEYSGAPKEDEVLQYARVVIDCAT--ANPDGKTRALVIGGGIANFTDVAATFNGII 383
L NY EYSGAP E + YA+ ++ T +PDGK L+IGG IANFT+VAATF GI+
Sbjct: 301 LANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGK--ILIIGGSIANFTNVAATFKGIV 358
Query: 382 RALKEKEAKLKAARMHIYVRRGGPNYQKGLAKMRSLGDEIGVPIEVYGPEATMTGICKEA 203
RA+++ + LK + I+VRRGGPNYQ+GL M +G G+PI V+G E MT I A
Sbjct: 359 RAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMA 418
Query: 202 I 200
+
Sbjct: 419 L 419
>sp|Q32PF2|ACLY_BOVIN ATP-citrate synthase OS=Bos taurus GN=ACLY PE=2 SV=1
Length = 1091
Score = 347 bits (889), Expect = 2e-094
Identities = 188/421 (44%), Positives = 258/421 (61%), Gaps = 7/421 (1%)
Frame = -1
Query: 1447 MARKKIREYDSKRLVKEHFKRLSGKELPIRSVQINQETDLNELVEKEPWLSSEKLVVKPD 1268
M+ K I E K L+ ++ S + + ++ +TD L++ PWL S+ LVVKPD
Sbjct: 1 MSAKAISEQTGKELLYKYICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQSLVVKPD 60
Query: 1267 MLFGKRGKSGLVALKLDFAEVATFVKERLGKEVEMSGCKGPITTFIVEPFVPH--NEEFY 1094
L +RGK GL+ + L V +++K RLG+E + G + F++EPFVPH EEFY
Sbjct: 61 QLIKRRGKLGLIGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHTQEEEFY 120
Query: 1093 LNIVSDRLGCSISFSECGGIDIEENWDKVKTISVPTGSSLTPE-ICAPLVATLPLEIKGE 917
+ I + R G + F GG+D+ + K + + V L PE I L+ P + K
Sbjct: 121 VCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEI 180
Query: 916 LEDFIQVIFTLFQDLDFTFLEMNPFALVDGKPYPLDMRGELDDTAAFKNFKKWGDIEFPM 737
L FI +F ++DL FT+LE+NP + Y LD+ ++D TA + KWGDIEFP
Sbjct: 181 LASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPP 240
Query: 736 PFGRVMSPTESFIHGLDEKTSASLKFTVLNPKGRIWTMVAGGGASVIYADTVGDLGYASE 557
PFGR P E++I LD K+ ASLK T+LNPKGRIWTMVAGGGASV+Y+DT+ DLG +E
Sbjct: 241 PFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNE 300
Query: 556 LGNYAEYSGAPKEDEVLQYARVVIDCAT--ANPDGKTRALVIGGGIANFTDVAATFNGII 383
L NY EYSGAP E + YA+ ++ T +PDGK L+IGG IANFT+VAATF GI+
Sbjct: 301 LANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGK--ILIIGGSIANFTNVAATFKGIV 358
Query: 382 RALKEKEAKLKAARMHIYVRRGGPNYQKGLAKMRSLGDEIGVPIEVYGPEATMTGICKEA 203
RA+++ + LK + I+VRRGGPNYQ+GL M +G G+PI V+G E MT I A
Sbjct: 359 RAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMA 418
Query: 202 I 200
+
Sbjct: 419 L 419
>sp|P53396|ACLY_HUMAN ATP-citrate synthase OS=Homo sapiens GN=ACLY PE=1 SV=3
Length = 1101
Score = 347 bits (888), Expect = 2e-094
Identities = 189/421 (44%), Positives = 258/421 (61%), Gaps = 7/421 (1%)
Frame = -1
Query: 1447 MARKKIREYDSKRLVKEHFKRLSGKELPIRSVQINQETDLNELVEKEPWLSSEKLVVKPD 1268
M+ K I E K L+ + S + + ++ +TD L++ PWL S+ LVVKPD
Sbjct: 1 MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPD 60
Query: 1267 MLFGKRGKSGLVALKLDFAEVATFVKERLGKEVEMSGCKGPITTFIVEPFVPHN--EEFY 1094
L +RGK GLV + L V +++K RLG+E + G + F++EPFVPH+ EEFY
Sbjct: 61 QLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFY 120
Query: 1093 LNIVSDRLGCSISFSECGGIDIEENWDKVKTISVPTGSSLTPE-ICAPLVATLPLEIKGE 917
+ I + R G + F GG+D+ + K + + V L PE I L+ P + K
Sbjct: 121 VCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEI 180
Query: 916 LEDFIQVIFTLFQDLDFTFLEMNPFALVDGKPYPLDMRGELDDTAAFKNFKKWGDIEFPM 737
L FI +F ++DL FT+LE+NP + Y LD+ ++D TA + KWGDIEFP
Sbjct: 181 LASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPP 240
Query: 736 PFGRVMSPTESFIHGLDEKTSASLKFTVLNPKGRIWTMVAGGGASVIYADTVGDLGYASE 557
PFGR P E++I LD K+ ASLK T+LNPKGRIWTMVAGGGASV+Y+DT+ DLG +E
Sbjct: 241 PFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNE 300
Query: 556 LGNYAEYSGAPKEDEVLQYARVVIDCAT--ANPDGKTRALVIGGGIANFTDVAATFNGII 383
L NY EYSGAP E + YA+ ++ T +PDGK L+IGG IANFT+VAATF GI+
Sbjct: 301 LANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGK--ILIIGGSIANFTNVAATFKGIV 358
Query: 382 RALKEKEAKLKAARMHIYVRRGGPNYQKGLAKMRSLGDEIGVPIEVYGPEATMTGICKEA 203
RA+++ + LK + I+VRRGGPNYQ+GL M +G G+PI V+G E MT I A
Sbjct: 359 RAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMA 418
Query: 202 I 200
+
Sbjct: 419 L 419
>sp|Q91V92|ACLY_MOUSE ATP-citrate synthase OS=Mus musculus GN=Acly PE=1 SV=1
Length = 1091
Score = 347 bits (888), Expect = 2e-094
Identities = 185/419 (44%), Positives = 256/419 (61%), Gaps = 3/419 (0%)
Frame = -1
Query: 1447 MARKKIREYDSKRLVKEHFKRLSGKELPIRSVQINQETDLNELVEKEPWLSSEKLVVKPD 1268
M+ K I E K L+ ++ S + + ++ +TD L++ PWL S+ LVVKPD
Sbjct: 1 MSAKAISEQTGKELLYKYICTTSAIQNRFKYARVTPDTDWAHLLQDHPWLLSQSLVVKPD 60
Query: 1267 MLFGKRGKSGLVALKLDFAEVATFVKERLGKEVEMSGCKGPITTFIVEPFVPHN--EEFY 1094
L +RGK GLV + L V +++K RLG E + KG + F++EPFVPH+ EEFY
Sbjct: 61 QLIKRRGKLGLVGVNLSLDGVKSWLKPRLGHEATVGKAKGFLKNFLIEPFVPHSQAEEFY 120
Query: 1093 LNIVSDRLGCSISFSECGGIDIEENWDKVKTISVPTGSSL-TPEICAPLVATLPLEIKGE 917
+ I + R G + F GG+D+ + K + + V L T +I L+ P + K
Sbjct: 121 VCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNTEDIKRHLLVHAPEDKKEV 180
Query: 916 LEDFIQVIFTLFQDLDFTFLEMNPFALVDGKPYPLDMRGELDDTAAFKNFKKWGDIEFPM 737
L FI +F ++DL FT+LE+NP + Y LD+ ++D TA + KWGDIEFP
Sbjct: 181 LASFISGLFNFYEDLYFTYLEINPLVVTKDGVYILDLAAKVDATADYICKVKWGDIEFPP 240
Query: 736 PFGRVMSPTESFIHGLDEKTSASLKFTVLNPKGRIWTMVAGGGASVIYADTVGDLGYASE 557
PFGR P E++I LD K+ ASLK T+LNPKGRIWTMVAGGGASV+Y+DT+ DLG +E
Sbjct: 241 PFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNE 300
Query: 556 LGNYAEYSGAPKEDEVLQYARVVIDCATANPDGKTRALVIGGGIANFTDVAATFNGIIRA 377
L NY EYSGAP E + YA+ ++ T + + L+IGG IANFT+VAATF GI+RA
Sbjct: 301 LANYGEYSGAPSEQQTYDYAKTILSLMTREKHPEGKILIIGGSIANFTNVAATFKGIVRA 360
Query: 376 LKEKEAKLKAARMHIYVRRGGPNYQKGLAKMRSLGDEIGVPIEVYGPEATMTGICKEAI 200
+++ + LK + I+VRRGGPNYQ+GL M +G G+PI V+G E MT I A+
Sbjct: 361 IRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMAL 419
>sp|P16638|ACLY_RAT ATP-citrate synthase OS=Rattus norvegicus GN=Acly PE=1 SV=1
Length = 1100
Score = 347 bits (888), Expect = 2e-094
Identities = 188/416 (45%), Positives = 256/416 (61%), Gaps = 7/416 (1%)
Frame = -1
Query: 1447 MARKKIREYDSKRLVKEHFKRLSGKELPIRSVQINQETDLNELVEKEPWLSSEKLVVKPD 1268
M+ K I E K L+ ++ S + + ++ +TD L++ PWL S+ LVVKPD
Sbjct: 1 MSAKAISEQTGKELLYKYICTTSAIQNRFKYARVTPDTDWAHLLQDHPWLLSQSLVVKPD 60
Query: 1267 MLFGKRGKSGLVALKLDFAEVATFVKERLGKEVEMSGCKGPITTFIVEPFVPHN--EEFY 1094
L +RGK GLV + L V +++K RLG E + KG + F++EPFVPH+ EEFY
Sbjct: 61 QLIKRRGKLGLVGVNLSLDGVKSWLKPRLGHEATVGKAKGFLKNFLIEPFVPHSQAEEFY 120
Query: 1093 LNIVSDRLGCSISFSECGGIDIEENWDKVKTISVPTGSSLTPE-ICAPLVATLPLEIKGE 917
+ I + R G + F GG+D+ + K + + V L E I L+ P + K
Sbjct: 121 VCIYATREGDYVLFHHEGGVDVGDVDTKAQKLLVGVDEKLNAEDIKRHLLVHAPEDKKEI 180
Query: 916 LEDFIQVIFTLFQDLDFTFLEMNPFALVDGKPYPLDMRGELDDTAAFKNFKKWGDIEFPM 737
L FI +F ++DL FT+LE+NP + Y LD+ ++D TA + KWGDIEFP
Sbjct: 181 LASFISGLFNFYEDLYFTYLEINPLVVTKDGVYILDLAAKVDATADYICKVKWGDIEFPP 240
Query: 736 PFGRVMSPTESFIHGLDEKTSASLKFTVLNPKGRIWTMVAGGGASVIYADTVGDLGYASE 557
PFGR P E++I LD K+ ASLK T+LNPKGRIWTMVAGGGASV+Y+DT+ DLG +E
Sbjct: 241 PFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNE 300
Query: 556 LGNYAEYSGAPKEDEVLQYARVVIDCAT--ANPDGKTRALVIGGGIANFTDVAATFNGII 383
L NY EYSGAP E + YA+ ++ T +PDGK L+IGG IANFT+VAATF GI+
Sbjct: 301 LANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGK--ILIIGGSIANFTNVAATFKGIV 358
Query: 382 RALKEKEAKLKAARMHIYVRRGGPNYQKGLAKMRSLGDEIGVPIEVYGPEATMTGI 215
RA+++ + LK + I+VRRGGPNYQ+GL M +G G+PI V+G E MT I
Sbjct: 359 RAIRDYQGSLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAI 414
>sp|P53585|ACLY_CAEEL Probable ATP-citrate synthase OS=Caenorhabditis elegans
GN=D1005.1 PE=2 SV=1
Length = 1106
Score = 201 bits (511), Expect = 1e-050
Identities = 100/187 (53%), Positives = 131/187 (70%), Gaps = 5/187 (2%)
Frame = -1
Query: 751 IEFPMPFGRVMSPTESFIHGLDEKTSASLKFTVLNPKGRIWTMVAGGGASVIYADTVGDL 572
+EFP PFGR ++ E +I +D KT ASLK T+LN KGR+WTMVAGGGASV++ DTV DL
Sbjct: 247 VEFPAPFGRDLTSEEQYISEMDAKTGASLKLTILNRKGRVWTMVAGGGASVVFTDTVCDL 306
Query: 571 GYASELGNYAEYSGAPKEDEVLQYARVVIDC---ATANPDGKTRALVIGGGIANFTDVAA 401
G ASEL NY EYSG P E + +YA+ ++ T PDGK L+IGG IANFT+VA
Sbjct: 307 GGASELANYGEYSGDPSESQTYEYAKTLLSVMTEGTPRPDGK--VLIIGGSIANFTNVAK 364
Query: 400 TFNGIIRALKEKEAKLKAARMHIYVRRGGPNYQKGLAKMRSLGDEIGVPIEVYGPEATMT 221
TF GI+RA + +KLK ++ I+VRRGGPNYQ+GL +++ ++ +PI V+GPE MT
Sbjct: 365 TFGGIVRAFETFVSKLKEHKVTIFVRRGGPNYQEGLRRIKDAATKLELPIHVFGPETHMT 424
Query: 220 GICKEAI 200
I A+
Sbjct: 425 AIVGAAL 431
>sp|O13907|ACL2_SCHPO Probable ATP-citrate synthase subunit 2
OS=Schizosaccharomyces pombe GN=SPAC22A12.16 PE=1 SV=1
Length = 492
Score = 192 bits (486), Expect = 8e-048
Identities = 94/178 (52%), Positives = 122/178 (68%), Gaps = 1/178 (0%)
Frame = -1
Query: 745 FPMPFGRVMSPTESFIHGLDEKTSASLKFTVLNPKGRIWTMVAGGGASVIYADTVGDLGY 566
FP PFGR +S E+++ GLD KT ASLK T+LN +GR+W +VAGGGASV+YAD V G
Sbjct: 298 FPAPFGRELSKEEAYVQGLDAKTGASLKLTILNAEGRVWNLVAGGGASVVYADAVAVNGA 357
Query: 565 ASELGNYAEYSGAPKEDEVLQYARVVIDCAT-ANPDGKTRALVIGGGIANFTDVAATFNG 389
A EL NY EYSGAP + + +YA+ V+D T P + L IGGGIANFT A TF
Sbjct: 358 ADELANYGEYSGAPTDGQTYEYAKTVLDLMTRGEPRADGKVLFIGGGIANFTSPAVTFRA 417
Query: 388 IIRALKEKEAKLKAARMHIYVRRGGPNYQKGLAKMRSLGDEIGVPIEVYGPEATMTGI 215
I RAL + + KL A ++ I+VRR GPNYQ+GL +R G + +P++VYGPE ++GI
Sbjct: 418 IARALGDYKDKLHAHKVSIWVRRAGPNYQEGLRVIREAGKKFDLPLKVYGPECHISGI 475
Score = 121 bits (303), Expect = 1e-026
Identities = 69/173 (39%), Positives = 103/173 (59%), Gaps = 6/173 (3%)
Frame = -1
Query: 1333 DLNELVEKE-PWLSSEKLVVKPDMLFGKRGKSGLVALKLDFAEVATFVKERLGKEVEMSG 1157
D+ VE+E PW+ KLV KPD L +RGKSGL+ L + E +++ER GK ++
Sbjct: 66 DVFAKVEQEHPWVKETKLVAKPDQLIKRRGKSGLLKLNATWDEAKEWIRERAGKNQKVQH 125
Query: 1156 CKGPITTFIVEPFVPH--NEEFYLNIVSDRLGCSISFSECGGIDIEENWDKVKTISVPTG 983
G +TTF+VEPFVPH N E+Y+NI S R G I F GG+D+ + K + + VP
Sbjct: 126 AVGYLTTFLVEPFVPHPPNTEYYININSVREGDWILFCNEGGVDVGDVDAKARKLLVPVR 185
Query: 982 SSLTPE---ICAPLVATLPLEIKGELEDFIQVIFTLFQDLDFTFLEMNPFALV 833
S P I + L++ +P+E L DFI +++++ D FT+LE+NP ++
Sbjct: 186 LSEFPSRATIASTLLSDIPVEQHESLVDFIIRLYSVYVDCQFTYLEINPLVVI 238
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,771,599,260
Number of Sequences: 518415
Number of Extensions: 58771599260
Number of Successful Extensions: 389091298
Number of sequences better than 0.0: 0
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