BLASTX 7.6.2
Query= UN14398 /QuerySize=2718
(2717 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9EQH3|VPS35_MOUSE Vacuolar protein sorting-associated protei... 575 9e-163
sp|Q2HJG5|VPS35_BOVIN Vacuolar protein sorting-associated protei... 573 3e-162
sp|Q96QK1|VPS35_HUMAN Vacuolar protein sorting-associated protei... 572 6e-162
sp|Q54C24|VPS35_DICDI Vacuolar sorting protein 35 OS=Dictyosteli... 565 6e-160
sp|P34110|VPS35_YEAST Vacuolar protein sorting-associated protei... 282 9e-075
sp|O74552|VPS35_SCHPO Vacuolar protein sorting-associated protei... 258 2e-067
>sp|Q9EQH3|VPS35_MOUSE Vacuolar protein sorting-associated protein 35 OS=Mus
musculus GN=Vps35 PE=1 SV=1
Length = 796
Score = 575 bits (1480), Expect = 9e-163
Identities = 306/674 (45%), Positives = 444/674 (65%), Gaps = 13/674 (1%)
Frame = +3
Query: 99 EDEEKWLAAGAAAFKQNAFYMQRAIDSNNLKDALKYSAQMLSELRTSKLSPHKYYDLYMR 278
+++EK L A K +F M+R +D N L DALK+++ ML ELRTS LSP YY+LYM
Sbjct: 10 DEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYMA 69
Query: 279 AFDELRKLEIFFMEETRRGCSVIELYELVQHAGNILPRLYLLCTAGSVYIKTKEAPAKEI 458
DEL LE++ +E +G V +LYELVQ+AGNI+PRLYLL T G VY+K+ K+I
Sbjct: 70 ISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDI 129
Query: 459 LKDLVEMCRGIQHPLRGLFLRSYLAQISRDKLPYIGSEY-EGDADTVTDAVEFVLLNFTE 635
LKDLVEMCRG+QHPLRGLFLR+YL Q +R+ LP G E ++D+++FVLLNF E
Sbjct: 130 LKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSMDFVLLNFAE 189
Query: 636 MNKLWVRMQHQGPAREKDKREKERSELRDLVGKNLHVLSQLEGVDLDMYRDTVLPRVLEQ 815
MNKLWVRMQHQG +R+++KRE+ER ELR LVG NL LSQLEGV+++ Y+ VL +LEQ
Sbjct: 190 MNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQIVLTGILEQ 249
Query: 816 IVNCRDEIAQYYLMDCIIQVFPDEYHLQTLDVLLGACPQLQPSVDIMTVLSRLMERLSSY 995
+VNCRD +AQ YLM+CIIQVFPDE+HLQTL+ L AC +L +V++ ++ L++RL+ +
Sbjct: 250 VVNCRDALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIIIALIDRLALF 309
Query: 996 AALNTEVLPYF-LQVEAFSKLNNAIGKVIEAQEDMPILSAVTLYSSLLKFTLHVHPDRLD 1172
A + E P +++ F + + VI++++DMP V+L SL+ + +PDR+D
Sbjct: 310 A--HREDGPGIPAEIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVD 367
Query: 1173 YADQVLGSCIKQLSGKGKIH---DTRATKELVTLLSAPLEKYNDVVIALKLTNYPLVMEY 1343
Y D+VL + ++ + H + +KEL LL P++ YN+++ LKL ++ + EY
Sbjct: 368 YVDKVLETTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEY 427
Query: 1344 LDSENKRVMATVIIRSIMKNKTVIATAEKVEALLELIKGLINDLDEPQGLEVDEDDFEEE 1523
D E+++ M+ ++ +++ T I + ++V++++ L+ LI D + + D +DF +E
Sbjct: 428 FDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPDPEDFADE 487
Query: 1524 QNSVARLIHMLYSDDPEEMFKIINVLKNHLLTGGPKRLKFTIPPLVVSALKLIRRLPEEG 1703
Q+ V R IH+L SDDP++ + I+N + H GG +R++FT+PPLV +A +L R E
Sbjct: 488 QSLVGRFIHLLRSDDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKEN- 546
Query: 1704 YNPFGKEASVSATKIFQFLNQIIEALPSAPSSPDLAFRLYLQCAEAANKC---DEEPIAY 1874
+ + KIF F +Q I AL A + +L RL+LQ A AA + + E +AY
Sbjct: 547 -SQMDDKWEKKCQKIFSFAHQTISALIKAELA-ELPLRLFLQGALAAGEIGFENHETVAY 604
Query: 1875 EFFTQAYILYEEEISDSKAQVTALQLIIGTLQRMHVFGVENRDTLTHKATGYSAKLLKKP 2054
EF +QA+ LYE+EISDSKAQ+ A+ LIIGT +RM F EN + L + ++KLLKKP
Sbjct: 605 EFMSQAFSLYEDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKLLKKP 664
Query: 2055 DQCRAVYACSHLFW 2096
DQ RAV C+HLFW
Sbjct: 665 DQGRAVSTCAHLFW 678
>sp|Q2HJG5|VPS35_BOVIN Vacuolar protein sorting-associated protein 35 OS=Bos
taurus GN=VPS35 PE=2 SV=1
Length = 796
Score = 573 bits (1476), Expect = 3e-162
Identities = 306/674 (45%), Positives = 443/674 (65%), Gaps = 13/674 (1%)
Frame = +3
Query: 99 EDEEKWLAAGAAAFKQNAFYMQRAIDSNNLKDALKYSAQMLSELRTSKLSPHKYYDLYMR 278
+++EK L A K +F M+R +D N L DALK+++ ML ELRTS LSP YY+LYM
Sbjct: 10 DEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYMA 69
Query: 279 AFDELRKLEIFFMEETRRGCSVIELYELVQHAGNILPRLYLLCTAGSVYIKTKEAPAKEI 458
DEL LE++ +E +G V +LYELVQ+AGNI+PRLYLL T G VY+K+ K+I
Sbjct: 70 ISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDI 129
Query: 459 LKDLVEMCRGIQHPLRGLFLRSYLAQISRDKLPYIGSEY-EGDADTVTDAVEFVLLNFTE 635
LKDLVEMCRG+QHPLRGLFLR+YL Q +R+ LP G E ++D+++FVLLNF E
Sbjct: 130 LKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSMDFVLLNFAE 189
Query: 636 MNKLWVRMQHQGPAREKDKREKERSELRDLVGKNLHVLSQLEGVDLDMYRDTVLPRVLEQ 815
MNKLWVRMQHQG +R+++KRE+ER ELR LVG NL LSQLEGV+++ Y+ VL +LEQ
Sbjct: 190 MNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQIVLTGILEQ 249
Query: 816 IVNCRDEIAQYYLMDCIIQVFPDEYHLQTLDVLLGACPQLQPSVDIMTVLSRLMERLSSY 995
+VNCRD +AQ YLM+CIIQVFPDE+HLQTL+ L AC +L +V++ ++ L++RL+ +
Sbjct: 250 VVNCRDALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIIIALIDRLALF 309
Query: 996 AALNTEVLPYF-LQVEAFSKLNNAIGKVIEAQEDMPILSAVTLYSSLLKFTLHVHPDRLD 1172
A + E P ++ F + + VI++++DMP V+L SL+ + +PDR+D
Sbjct: 310 A--HREDGPGIPTDIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVD 367
Query: 1173 YADQVLGSCIKQLSGKGKIH---DTRATKELVTLLSAPLEKYNDVVIALKLTNYPLVMEY 1343
Y D+VL + ++ + H + +KEL LL P++ YN+++ LKL ++ + EY
Sbjct: 368 YVDKVLETTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEY 427
Query: 1344 LDSENKRVMATVIIRSIMKNKTVIATAEKVEALLELIKGLINDLDEPQGLEVDEDDFEEE 1523
D E+++ M+ ++ +++ T I + ++V++++ L+ LI D + E D +DF +E
Sbjct: 428 FDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEEPDPEDFADE 487
Query: 1524 QNSVARLIHMLYSDDPEEMFKIINVLKNHLLTGGPKRLKFTIPPLVVSALKLIRRLPEEG 1703
Q+ V R IH+L S+DP++ + I+N + H GG +R++FT+PPLV +A +L R E
Sbjct: 488 QSLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKEN- 546
Query: 1704 YNPFGKEASVSATKIFQFLNQIIEALPSAPSSPDLAFRLYLQCAEAANKC---DEEPIAY 1874
+ + KIF F +Q I AL A + +L RL+LQ A AA + + E +AY
Sbjct: 547 -SKVDDKWEKKCQKIFSFAHQTISALIKAELA-ELPLRLFLQGALAAGEIGFENHETVAY 604
Query: 1875 EFFTQAYILYEEEISDSKAQVTALQLIIGTLQRMHVFGVENRDTLTHKATGYSAKLLKKP 2054
EF +QA+ LYE+EISDSKAQ+ A+ LIIGT +RM F EN + L + ++KLLKKP
Sbjct: 605 EFMSQAFSLYEDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKLLKKP 664
Query: 2055 DQCRAVYACSHLFW 2096
DQ RAV C+HLFW
Sbjct: 665 DQGRAVSTCAHLFW 678
Score = 64 bits (155), Expect = 4e-009
Identities = 44/138 (31%), Positives = 67/138 (48%), Gaps = 13/138 (9%)
Frame = +2
Query: 2036 KTSKETRPVSSCLCLLSS--VLARRSWTIQDGERVLRCLKRALKIANSAQQMTSAARGST 2209
K + R VS+C L S + + G+RV+ CLK+ALKIAN +
Sbjct: 662 KKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSL------ 715
Query: 2210 GSVTLFIEILNKYLYFFEKGIPQITVESVESMIQLIK----NEESLTSDQSAESFLASTL 2377
V LFIEILN+Y+YF+EK +T++ + +IQ I+ N ES + +TL
Sbjct: 716 -QVQLFIEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINKHFHNTL 774
Query: 2378 RFMEFQKQKGGVVGDRYE 2431
+ +++ G YE
Sbjct: 775 EHLRLRRESPESEGPIYE 792
>sp|Q96QK1|VPS35_HUMAN Vacuolar protein sorting-associated protein 35 OS=Homo
sapiens GN=VPS35 PE=1 SV=2
Length = 796
Score = 572 bits (1473), Expect = 6e-162
Identities = 305/674 (45%), Positives = 443/674 (65%), Gaps = 13/674 (1%)
Frame = +3
Query: 99 EDEEKWLAAGAAAFKQNAFYMQRAIDSNNLKDALKYSAQMLSELRTSKLSPHKYYDLYMR 278
+++EK L A K +F M+R +D N L DALK+++ ML ELRTS LSP YY+LYM
Sbjct: 10 DEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYMA 69
Query: 279 AFDELRKLEIFFMEETRRGCSVIELYELVQHAGNILPRLYLLCTAGSVYIKTKEAPAKEI 458
DEL LE++ +E +G V +LYELVQ+AGNI+PRLYLL T G VY+K+ K+I
Sbjct: 70 ISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDI 129
Query: 459 LKDLVEMCRGIQHPLRGLFLRSYLAQISRDKLPYIGSEY-EGDADTVTDAVEFVLLNFTE 635
LKDLVEMCRG+QHPLRGLFLR+YL Q +R+ LP G E ++D+++FVLLNF E
Sbjct: 130 LKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSMDFVLLNFAE 189
Query: 636 MNKLWVRMQHQGPAREKDKREKERSELRDLVGKNLHVLSQLEGVDLDMYRDTVLPRVLEQ 815
MNKLWVRMQHQG +R+++KRE+ER ELR LVG NL LSQLEGV+++ Y+ VL +LEQ
Sbjct: 190 MNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQIVLTGILEQ 249
Query: 816 IVNCRDEIAQYYLMDCIIQVFPDEYHLQTLDVLLGACPQLQPSVDIMTVLSRLMERLSSY 995
+VNCRD +AQ YLM+CIIQVFPDE+HLQTL+ L AC +L +V++ ++ L++RL+ +
Sbjct: 250 VVNCRDALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIIIALIDRLALF 309
Query: 996 AALNTEVLPYF-LQVEAFSKLNNAIGKVIEAQEDMPILSAVTLYSSLLKFTLHVHPDRLD 1172
A + E P ++ F + + VI++++DMP V+L SL+ + +PDR+D
Sbjct: 310 A--HREDGPGIPADIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVD 367
Query: 1173 YADQVLGSCIKQLSGKGKIH---DTRATKELVTLLSAPLEKYNDVVIALKLTNYPLVMEY 1343
Y D+VL + ++ + H + +KEL LL P++ YN+++ LKL ++ + EY
Sbjct: 368 YVDKVLETTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEY 427
Query: 1344 LDSENKRVMATVIIRSIMKNKTVIATAEKVEALLELIKGLINDLDEPQGLEVDEDDFEEE 1523
D E+++ M+ ++ +++ T I + ++V++++ L+ LI D + + D +DF +E
Sbjct: 428 FDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPDPEDFADE 487
Query: 1524 QNSVARLIHMLYSDDPEEMFKIINVLKNHLLTGGPKRLKFTIPPLVVSALKLIRRLPEEG 1703
Q+ V R IH+L S+DP++ + I+N + H GG +R++FT+PPLV +A +L R E
Sbjct: 488 QSLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKEN- 546
Query: 1704 YNPFGKEASVSATKIFQFLNQIIEALPSAPSSPDLAFRLYLQCAEAANKC---DEEPIAY 1874
+ + KIF F +Q I AL A + +L RL+LQ A AA + + E +AY
Sbjct: 547 -SKVDDKWEKKCQKIFSFAHQTISALIKAELA-ELPLRLFLQGALAAGEIGFENHETVAY 604
Query: 1875 EFFTQAYILYEEEISDSKAQVTALQLIIGTLQRMHVFGVENRDTLTHKATGYSAKLLKKP 2054
EF +QA+ LYE+EISDSKAQ+ A+ LIIGT +RM F EN + L + ++KLLKKP
Sbjct: 605 EFMSQAFSLYEDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKLLKKP 664
Query: 2055 DQCRAVYACSHLFW 2096
DQ RAV C+HLFW
Sbjct: 665 DQGRAVSTCAHLFW 678
>sp|Q54C24|VPS35_DICDI Vacuolar sorting protein 35 OS=Dictyostelium discoideum
GN=vps35 PE=3 SV=1
Length = 781
Score = 565 bits (1456), Expect = 6e-160
Identities = 303/714 (42%), Positives = 462/714 (64%), Gaps = 14/714 (1%)
Frame = +3
Query: 99 EDEEKWLAAGAAAFKQNAFYMQRAIDSNNLKDALKYSAQMLSELRTSKLSPHKYYDLYMR 278
E++ K+ +M+ ++D++ L DALKY++ +++ELRTS LSP YY LY+
Sbjct: 17 EEQAKFFEEAKNNVMIQGHHMKLSLDNSKLMDALKYASNIINELRTSLLSPKSYYALYLV 76
Query: 279 AFDELRKLEIFFMEETRRGCSVIELYELVQHAGNILPRLYLLCTAGSVYIKTKEAPAKEI 458
AFD L+ L + EE + G +IELYE+VQHAGN+LPRLYLL T GSVYIKTK+APAK++
Sbjct: 77 AFDYLQYLNTYLYEE-KHGKKMIELYEVVQHAGNVLPRLYLLITVGSVYIKTKQAPAKDV 135
Query: 459 LKDLVEMCRGIQHPLRGLFLRSYLAQISRDKLPYIGSEYEGDADTVTDAVEFVLLNFTEM 638
LKDL+EMCRG+QHP RGLFLR YL+++++DKLP I S E TV D+++F++ NFTE
Sbjct: 136 LKDLIEMCRGVQHPTRGLFLRHYLSEVTKDKLPDIDSSVEN--GTVMDSIDFIIQNFTET 193
Query: 639 NKLWVRMQHQGPAREKDKREKERSELRDLVGKNLHVLSQLEGVDLDMYRDTVLPRVLEQI 818
NKLWVRMQHQ P +++++RE ER ELR LVGKNL L+QL+GVD Y + VLP+V+EQI
Sbjct: 194 NKLWVRMQHQAPTKDRERRENERLELRLLVGKNLSRLAQLDGVDQKTYSEVVLPKVVEQI 253
Query: 819 VNCRDEIAQYYLMDCIIQVFPDEYHLQTLDVLLGACPQLQPSVDIMTVLSRLMERLSSYA 998
+NC+D+IAQ YLM+ +IQVFPDE+HL TLD++L C QLQ VD+ T+++ L++RL+++A
Sbjct: 254 INCKDKIAQQYLMEILIQVFPDEFHLATLDIILQTCAQLQSGVDVKTIIASLIDRLANFA 313
Query: 999 ALNTEVLPYFLQVEAFSKLNNAIGKVIEAQEDMPILSAVTLYSSLLKFTLHVHPDRLDYA 1178
N +++P ++ F N + ++I+A+ +M + + L+ SLL TL +P D A
Sbjct: 314 TRNADLVPD--NIKIFDIFFNNVKEIIQARPNMELQDILGLHVSLLNLTLKCYPTNKDNA 371
Query: 1179 DQVLGSCIKQLSGKGK--IHDTRATKELVTLLSAPLEKYNDVVIALKLTNYPLVMEYLDS 1352
++VLG C + K K I+ K+++ LL PL+ + +V++ LKL+NY ++ L
Sbjct: 372 NEVLGLCQSIIVNKAKEDINKPTCVKQIIQLLQIPLDVFKNVLVVLKLSNYQPLISCLSY 431
Query: 1353 ENKRVMATVIIRSIMKNKTVIATAEKVEALLELIKGLIND-LDEPQGLEVDEDDFEEEQN 1529
N++ ++ I+ + + N T+I E V LLE I+ LI D D+P ++D++DF+EEQN
Sbjct: 432 NNRKKVSLDIVNNTINNSTIIEEPEAVNNLLETIQTLIKDEQDQPDMDDIDKEDFQEEQN 491
Query: 1530 SVARLIHMLYSDDPEEMFKIINVLKNHLLTGGPKRLKFTIPPLVVSALKLIRRLPEE--- 1700
VA LIH+ S+DPE++FKI + + H GGP R++ T+ PLV +L+ IR ++
Sbjct: 492 KVASLIHLFDSEDPEKLFKIYIIARGHFGKGGPHRIRHTLVPLVFCSLRFIRNFKQQVDS 551
Query: 1701 GYNPFGKEASVS-ATKIFQFLNQIIEALPSAPSSPDLAFRLYLQCAEAANKCDEEPIAYE 1877
G + ++ +KIF F+++ I+AL + DL+FRLYLQ + + C E
Sbjct: 552 GVISLDENKWIAIGSKIFTFVSETIKALADIKLA-DLSFRLYLQALQTFDHCGLVSRVKE 610
Query: 1878 FFTQAYILYEEEISDSKAQVTALQLIIGTLQRMHVFGVENRDTLTHKATGYSAKLLKKPD 2057
+A ++++E+I+D KAQV ALQL+I TL + + E ++L + +++LL D
Sbjct: 611 LAIKALLIFQEDIADFKAQVMALQLLISTLNSLSIPNEEIYESLAAQTIKQASRLLLPQD 670
Query: 2058 QCRAVYACSHLFWLEDHGPYKMEKGFCVVSNERLKLQIQLNK*PAQLGVVQDLL 2219
Q + + CSHLFW+ D+ + + V+ + L I N+ LG D+L
Sbjct: 671 QAKLISTCSHLFWV-DNPSRQYQNPDSVLQALKKALSIISNESSPGLGTFVDIL 723
>sp|P34110|VPS35_YEAST Vacuolar protein sorting-associated protein 35
OS=Saccharomyces cerevisiae GN=VPS35 PE=1 SV=2
Length = 944
Score = 282 bits (721), Expect = 9e-075
Identities = 163/485 (33%), Positives = 271/485 (55%), Gaps = 24/485 (4%)
Frame = +3
Query: 132 AAFKQNAFYMQRAIDSNNLKDALKYSAQMLSELRTSKLSPHKYYDLYMRAFDELRKLEIF 311
A KQ M R + + L ++L++++ ML+ELR LSP KYY+LY+ FD L L +
Sbjct: 12 AVIKQRTALMNRCLSQHKLMESLQHTSIMLTELRNPNLSPKKYYELYVIIFDSLTNLSTY 71
Query: 312 FMEETRRGCSVIELYELVQHAGNILPRLYLLCTAGSVYIKTKEAPAKEILKDLVEMCRGI 491
+E + + +LYELVQ+ GN++PRLYL+ T G+ Y+ EAP KEILKD++EMCRG+
Sbjct: 72 LIENHPQNHHLADLYELVQYTGNVVPRLYLMITVGTSYLTFNEAPKKEILKDMIEMCRGV 131
Query: 492 QHPLRGLFLRSYLAQISRDKLPYIGSEYEGDADTVTDAVEFVLLNFTEMNKLWVRMQHQG 671
Q+P+RGLFLR YL+Q +++ LP D + +F++ NF EMNKLWVR+QHQG
Sbjct: 132 QNPIRGLFLRYYLSQRTKELLP---------EDDPSFNSQFIMNNFIEMNKLWVRLQHQG 182
Query: 672 PAREKDKREKERSELRDLVGKNLHVLSQLEGVDLDMYRDTVLPRVLEQIVNCRDEIAQYY 851
P RE++ R +ER EL+ LVG L LSQ+ + MY+ +LP +LEQ++ CRD ++Q Y
Sbjct: 183 PLRERETRTRERKELQILVGSQLVRLSQIIDDNFQMYKQDILPTILEQVIQCRDLVSQEY 242
Query: 852 LMDCIIQVFPDEYHLQTLDVLLGACPQLQPSVDIMTVLSRLMERLSSYAALNTEVLP--- 1022
L+D I QVF DE+HL+TLD LL L P V I ++ L++RL+ Y E P
Sbjct: 243 LLDVICQVFADEFHLKTLDTLLQTTLHLNPDVSINKIVLTLVDRLNDYVTRQLEDDPNAT 302
Query: 1023 ---YFLQVEAFSKLNNAIGKVIEAQEDMPILSAVTLYSSLLKFTLHVHPDRLDYADQVLG 1193
+L ++ F + + + + D+ + + L S++ +L +P+ D +++
Sbjct: 303 STNAYLDMDVFGTFWDYLTVLNHERPDLSLQQFIPLVESVIVLSLKWYPNNFDNLNKLFE 362
Query: 1194 SCIKQLSGKGKIHDTRATKEL-VTLLSAPLEKYNDVVIALKLTNYPLVMEYLDSENKRVM 1370
+++ G+ + + ++ L + LLS K L+LT+ +K+
Sbjct: 363 LVLQKTKDYGQKNISLESEHLFLVLLSFQNSK-------LQLTSSTTAPPNSPVTSKKHF 415
Query: 1371 ATVIIRSIMKNKTVIATAEKVEALLELIKGLINDLDEPQGLEVDEDDFEEEQNSVARLIH 1550
+I K ++A + + +++ +I+ L + + E+ ++D E + + +
Sbjct: 416 IFQLISQCQAYKNILA-LQSISLQKKVVNEIIDILMDREVEEMADNDSESKLHPPGHSAY 474
Query: 1551 MLYSD 1565
++ D
Sbjct: 475 LVIED 479
Score = 93 bits (229), Expect = 1e-017
Identities = 52/133 (39%), Positives = 83/133 (62%), Gaps = 3/133 (2%)
Frame = +3
Query: 1743 KIFQFLNQIIEALPSA--PSSPDLAFRLYLQCAEAANKCDEEPIAYEFFTQAYILYEEEI 1916
++F+F+++ I + ++ S DL +L LQCA A++ I+Y+FF+QA+ ++EE +
Sbjct: 625 QMFKFVSRCINDIFNSCNNSCTDLILKLNLQCAILADQLQLNEISYDFFSQAFTIFEESL 684
Query: 1917 SDSKAQVTALQLIIGTLQRMH-VFGVENRDTLTHKATGYSAKLLKKPDQCRAVYACSHLF 2093
SDSK Q+ AL I +LQ+ ++ D+L + T + +KLLKK DQCRAVY CSHL+
Sbjct: 685 SDSKTQLQALIYIAQSLQKTRSLYKEAYYDSLIVRCTLHGSKLLKKQDQCRAVYLCSHLW 744
Query: 2094 WLEDHGPYKMEKG 2132
W + E+G
Sbjct: 745 WATEISNIGEEEG 757
>sp|O74552|VPS35_SCHPO Vacuolar protein sorting-associated protein 35
OS=Schizosaccharomyces pombe GN=vps35 PE=1 SV=1
Length = 785
Score = 258 bits (658), Expect = 2e-067
Identities = 135/260 (51%), Positives = 184/260 (70%), Gaps = 6/260 (2%)
Frame = +3
Query: 228 LRTSKLSPHKYYDLYMRAFDELRKLEIFFMEETRRGC-SVIELYELVQHAGNILPRLYLL 404
+R S L+P +YY+LYM + LR L +E G ++++LYELVQ+AG+I+PRLYL+
Sbjct: 1 MRNSALTPKQYYELYMFNMESLRLLGGTLLETHLNGTHNLMDLYELVQYAGSIVPRLYLM 60
Query: 405 CTAGSVYIKTKEAPAKEILKDLVEMCRGIQHPLRGLFLRSYLAQISRDKLPYIGSEYEGD 584
T GS Y++T A +EI+ DL++MCRG+QHPLRGLFLR YL +R LP +GSE E D
Sbjct: 61 ITVGSAYLETPNALVREIMNDLLDMCRGVQHPLRGLFLRHYLLTQTRKGLP-LGSEDEED 119
Query: 585 AD---TVTDAVEFVLLNFTEMNKLWVRMQHQGPAREKDKREKERSELRDLVGKNLHVLSQ 755
A TV D+V+F+++NFTEMNKLWVR+QH GP +E KR +ER+EL+ LVG NL LSQ
Sbjct: 120 ASRKGTVLDSVKFLVINFTEMNKLWVRIQHLGPIKEFSKRTQERNELKVLVGLNLVRLSQ 179
Query: 756 LEGVDLDMYRDTVLPRVLEQIVNCRDEIAQYYLMDCIIQVFPDEYHLQTLDVLLGACPQL 935
L +D+D YRD VLP ++EQI+ CRD +AQ YL++ I Q F D HLQTLD G +L
Sbjct: 180 L-NLDIDTYRDHVLPAIIEQIIECRDSLAQEYLVEVICQAFSDNMHLQTLDTYFGTVIKL 238
Query: 936 QPSVDIMTVLSRLMERLSSY 995
PSV++ ++ ++ RL+ Y
Sbjct: 239 SPSVNVTQLVVAMLNRLTDY 258
Score = 129 bits (323), Expect = 1e-028
Identities = 96/309 (31%), Positives = 153/309 (49%), Gaps = 22/309 (7%)
Frame = +3
Query: 1275 PLEKYNDVVIALKLTNYPLVMEYLDSENKRVMATV---IIRSIMKNKTVIATAEKVEALL 1445
PL+K ++ L LT +P L+ +N + +R + V EK +L
Sbjct: 379 PLQKSLCAILLLPLTYFPSFSYCLELQNFLPVFNAQDPNLRYDIARMIVQKIIEKGHSLS 438
Query: 1446 ELIKGLINDLDEPQG-----LEVDEDDFEEEQNSVARLIHMLYSDDPEEMFKIINVLKNH 1610
EL + E G +E D ++ +VA ++H L +DDP+ +I+ LK+
Sbjct: 439 EL-----TEAQELLGFVSVIIEKKGVDSLDDLQNVALMVHYLNNDDPQIQIEILRSLKDT 493
Query: 1611 LLTGGPKRLKFTIPPLVVSALKLIRRLPEEGYNPFGKEASVSATKIFQFLNQIIEALPSA 1790
+ G + +K+ +P +V + L R + ++ + +++F+N I L
Sbjct: 494 FIKAG-ENVKYLLPVVVNRCIFLARNFRIFKCMDWAEKVRL----LWEFVNTCINVLYKN 548
Query: 1791 PSSPDLAFRLYLQCAEAANKCDEEPIAYEFFTQAYILYEEEISDSKAQVTALQLIIGTLQ 1970
S +L LYL AE A++ + AYEFFTQA+ +YEE + DS+ Q L +IIG LQ
Sbjct: 549 GDSLELCLALYLSAAEMADQENYPDFAYEFFTQAFSIYEESVLDSELQYQQLLMIIGKLQ 608
Query: 1971 RMHVFGVENRDTLTHKATGYSAKLLKKPDQCRAVYACSHLFWL----EDHGPYKMEKGFC 2138
+ F V++ DTL K T Y++KLLKKPDQC +Y SHL+W ED P++ K
Sbjct: 609 KTRNFSVDDYDTLITKCTLYASKLLKKPDQCCGIYLASHLWWQVASGEDSRPFQDPKRVL 668
Query: 2139 VVSNERLKL 2165
+ LK+
Sbjct: 669 ECLQKSLKI 677
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,771,599,260
Number of Sequences: 518415
Number of Extensions: 58771599260
Number of Successful Extensions: 389091298
Number of sequences better than 0.0: 0
|
