BLASTX 7.6.2
Query= UN14523 /QuerySize=1638
(1637 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P25889|YEIA_ECOLI Uncharacterized protein yeiA OS=Escherichia... 253 3e-066
sp|Q12882|DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP+] OS=... 221 2e-056
sp|Q8CHR6|DPYD_MOUSE Dihydropyrimidine dehydrogenase [NADP+] OS=... 221 2e-056
sp|A8XKG6|DPYD_CAEBR Probable dihydropyrimidine dehydrogenase [N... 219 5e-056
sp|Q5R895|DPYD_PONAB Dihydropyrimidine dehydrogenase [NADP+] OS=... 219 5e-056
sp|Q18164|DPYD_CAEEL Dihydropyrimidine dehydrogenase [NADP+] OS=... 219 7e-056
sp|O89000|DPYD_RAT Dihydropyrimidine dehydrogenase [NADP+] OS=Ra... 218 1e-055
sp|Q28943|DPYD_PIG Dihydropyrimidine dehydrogenase [NADP+] OS=Su... 218 2e-055
sp|Q55FT1|DPYD_DICDI Dihydropyrimidine dehydrogenase [NADP+] OS=... 215 8e-055
sp|Q28007|DPYD_BOVIN Dihydropyrimidine dehydrogenase [NADP+] OS=... 215 1e-054
sp|Q6NYG8|DPYD_DANRE Dihydropyrimidine dehydrogenase [NADP+] OS=... 214 2e-054
sp|Q9V0Y6|PYRD_PYRAB Dihydroorotate dehydrogenase OS=Pyrococcus ... 95 1e-018
sp|Q8U0P6|PYRD_PYRFU Dihydroorotate dehydrogenase OS=Pyrococcus ... 94 3e-018
sp|Q5JHR7|PYRD_PYRKO Dihydroorotate dehydrogenase OS=Pyrococcus ... 89 6e-017
sp|Q58070|PYRD_METJA Dihydroorotate dehydrogenase OS=Methanocald... 81 2e-014
sp|Q8PW56|PYRD_METMA Dihydroorotate dehydrogenase OS=Methanosarc... 81 2e-014
sp|Q8TT55|PYRD_METAC Dihydroorotate dehydrogenase OS=Methanosarc... 80 5e-014
sp|Q6A912|PYRD_PROAC Dihydroorotate dehydrogenase OS=Propionibac... 74 2e-012
sp|Q6V3X0|PYRD_SACCA Dihydroorotate dehydrogenase OS=Saccharomyc... 55 1e-006
>sp|P25889|YEIA_ECOLI Uncharacterized protein yeiA OS=Escherichia coli (strain
K12) GN=yeiA PE=3 SV=3
Length = 411
Score = 253 bits (645), Expect = 3e-066
Identities = 143/337 (42%), Positives = 202/337 (59%), Gaps = 10/337 (2%)
Frame = +2
Query: 230 DLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPRYA 409
DLS+T G+K PNPF + S P G Y + +A+D GWGGV+ KT+ + V+PR+
Sbjct: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIAN--EVSPRFD 62
Query: 410 RLRTGSAKTDVIGWQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYTKTGWEEL 589
L T IG++N+E I++ PLE L ++LK++YPD++LIASIM E + WEEL
Sbjct: 63 HL--VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE-NEQQWEEL 119
Query: 590 IDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLEEVCGWINAKATVPVWAKMTPN 769
V++ G D +E NFSCP M MG+ VGQ L+E+ C + +T+P+ AKMTPN
Sbjct: 120 ARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178
Query: 770 ITDITEPARVSLKSGCEGIAAINTIMSVMGIDLKTLHPEPCVEGYSTPGGYSYKAVRPIA 949
I D+ E A + + G +GIAAINT+ S+ IDL P V G S+ GYS KAV+PIA
Sbjct: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238
Query: 950 LAKVMNIAKMMRDEFSEKDCSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMVHGYGHVK 1129
L + MR +D +SGIGG+ET DAAEF+LLG+ T+QV TG+M +GY V+
Sbjct: 239 L----RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294
Query: 1130 TLCAELRDFMKQHNFSTIEEFRGHSLQYFTTHTDLVR 1240
+ + L ++ F +++E G + DL R
Sbjct: 295 DMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDR 331
>sp|Q12882|DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP+] OS=Homo sapiens
GN=DPYD PE=1 SV=2
Length = 1025
Score = 221 bits (561), Expect = 2e-056
Identities = 120/331 (36%), Positives = 184/331 (55%), Gaps = 15/331 (4%)
Frame = +2
Query: 230 DLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPRYA 409
D+SV + GLK NPF + S P T+ ++++RAF+ GWG + KT SLD V NV+PR
Sbjct: 532 DISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRII 591
Query: 410 RLRTGSAKTDVIG-----WQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYTKT 574
R G+ + G + NIELIS++ + +LK ++PD I+IASIM Y K
Sbjct: 592 R---GTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKN 648
Query: 575 GWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLEEVCGWINAKATVPVWA 754
W EL + E +G DALE+N SCPHGM ER MG A GQD L+ +C W+ +P +A
Sbjct: 649 DWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFA 708
Query: 755 KMTPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDLK-TLHPEPCVEGYSTPGGYSYK 931
K+TPN+TDI AR + + G G+ A NT+ +MG+ T P + +T GG S
Sbjct: 709 KLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGT 768
Query: 932 AVRPIALAKVMNIAKMMRDEFSEKDCSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMVH 1111
A+RPIAL V +IA+ + + GG+++ +F+ G++ +QVC+ +
Sbjct: 769 AIRPIALRAVTSIARAL------PGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQ 822
Query: 1112 GYGHVKTLCAELRDFMKQHNFSTIEEFRGHS 1204
+ ++ C L+ + + ++++ G S
Sbjct: 823 DFTVIEDYCTGLKALLYLKSIEELQDWDGQS 853
>sp|Q8CHR6|DPYD_MOUSE Dihydropyrimidine dehydrogenase [NADP+] OS=Mus musculus
GN=Dpyd PE=2 SV=1
Length = 1025
Score = 221 bits (561), Expect = 2e-056
Identities = 122/331 (36%), Positives = 182/331 (54%), Gaps = 15/331 (4%)
Frame = +2
Query: 230 DLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPRYA 409
D+SV + GL+ PNPF + S P T+ +++RAF+ GWG + KT SLD V NV+PR
Sbjct: 532 DISVEMAGLRFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRII 591
Query: 410 RLRTGSAKTDVIG-----WQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYTKT 574
R G+ + G + NIELIS++ +LK ++PD ILIASIM Y K+
Sbjct: 592 R---GTTSGPLYGPGQSSFLNIELISEKTAAYWCHSVTELKADFPDNILIASIMCSYNKS 648
Query: 575 GWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLEEVCGWINAKATVPVWA 754
W EL E +G DALE+N SCPHGM ER MG A GQD L+ +C W+ VP +A
Sbjct: 649 DWMELSKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVRVPFFA 708
Query: 755 KMTPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDLK-TLHPEPCVEGYSTPGGYSYK 931
K+TPN+TDI AR + + G +G+ A NT+ +MG+ T P + +T GG S
Sbjct: 709 KLTPNVTDIVSIARAAKEGGADGVTATNTVSGLMGLKADGTPWPAVGIGRRTTYGGVSGT 768
Query: 932 AVRPIALAKVMNIAKMMRDEFSEKDCSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMVH 1111
A+RPIAL V IA+ + + GG+++ +F+ G++ +QVC+ +
Sbjct: 769 AIRPIALRAVTAIARAL------PGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQ 822
Query: 1112 GYGHVKTLCAELRDFMKQHNFSTIEEFRGHS 1204
+ ++ C L+ + + + ++ G S
Sbjct: 823 DFTVIEDYCTGLKALLYLKSIEELADWDGQS 853
>sp|A8XKG6|DPYD_CAEBR Probable dihydropyrimidine dehydrogenase [NADP+]
OS=Caenorhabditis briggsae GN=dpyd-1 PE=3 SV=2
Length = 1053
Score = 219 bits (557), Expect = 5e-056
Identities = 124/333 (37%), Positives = 187/333 (56%), Gaps = 15/333 (4%)
Frame = +2
Query: 224 EPDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPR 403
E D+SV + G+K NPF + S PP T+ + +RAF++GWG ++ KT LD V NV+PR
Sbjct: 554 EVDISVDMCGVKFENPFGLASAPPTTSGPMCRRAFEQGWGFILTKTYGLDKDLVTNVSPR 613
Query: 404 YARLRTGSAKTDVIG-----WQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYT 568
R GS + G + NIELIS++ E L+ ++LK+++P +I++ASIM Y
Sbjct: 614 IVR---GSTSGPLYGPNQGSFMNIELISEKSCEYWLQCIRELKRDHPTKIVVASIMCVYN 670
Query: 569 KTGWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLEEVCGWINAKATVPV 748
K W EL + E G D LE+N SCPHGM E+ MG A GQ +++E+C W+ A +P
Sbjct: 671 KEDWIELATKSEAAGADILELNLSCPHGMGEKGMGLACGQSPEIVKEICRWVRACVKIPF 730
Query: 749 WAKMTPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDLK-TLHPEPCVEGYSTPGGYS 925
+ KMTPNITD+ E AR + G G+ A NT+ S+M + P +T GG S
Sbjct: 731 FPKMTPNITDVREIARAARDGGASGVTATNTVSSLMHMKADGNAWPAIGNTKRTTYGGMS 790
Query: 926 YKAVRPIALAKVMNIAKMMRDEFSEKDCSLSGIGGVETGYDAAEFILLGSNTVQVCTGVM 1105
A+RPIA+ V +IA + D F + GG+E+ F++ G++ +QVC+ V
Sbjct: 791 GSAIRPIAMKAVSSIANEL-DGF-----PIMATGGIESAETGLGFLMAGASVLQVCSAVQ 844
Query: 1106 VHGYGHVKTLCAELRDFMKQHNFSTIEEFRGHS 1204
+ V+ C L+ + +++E+ G S
Sbjct: 845 NQDFTVVEDYCTGLKALLYLSGAESLKEWDGQS 877
>sp|Q5R895|DPYD_PONAB Dihydropyrimidine dehydrogenase [NADP+] OS=Pongo abelii
GN=DPYD PE=2 SV=1
Length = 1025
Score = 219 bits (557), Expect = 5e-056
Identities = 119/331 (35%), Positives = 183/331 (55%), Gaps = 15/331 (4%)
Frame = +2
Query: 230 DLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPRYA 409
D+SV + GLK NPF + S P T+ ++++RAF+ GWG + KT SLD V NV+PR
Sbjct: 532 DISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIV 591
Query: 410 RLRTGSAKTDVIG-----WQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYTKT 574
R G+ + G + NIELIS++ + +LK ++PD I+IASIM Y K
Sbjct: 592 R---GTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKN 648
Query: 575 GWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLEEVCGWINAKATVPVWA 754
W EL + E +G DALE+N SCPHGM ER MG A GQD L+ +C W+ +P +A
Sbjct: 649 DWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFA 708
Query: 755 KMTPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDLK-TLHPEPCVEGYSTPGGYSYK 931
K+TPN+TDI AR + + G G+ A NT+ +MG+ T P + +T GG S
Sbjct: 709 KLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGT 768
Query: 932 AVRPIALAKVMNIAKMMRDEFSEKDCSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMVH 1111
A+RPIAL V + A+ + + GG+++ +F+ G++ +QVC+ +
Sbjct: 769 AIRPIALRAVTSTARAL------PGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQ 822
Query: 1112 GYGHVKTLCAELRDFMKQHNFSTIEEFRGHS 1204
+ ++ C L+ + + ++++ G S
Sbjct: 823 DFTVIEDYCTGLKALLYLKSIEELQDWDGQS 853
>sp|Q18164|DPYD_CAEEL Dihydropyrimidine dehydrogenase [NADP+] OS=Caenorhabditis
elegans GN=dpyd-1 PE=2 SV=2
Length = 1059
Score = 219 bits (556), Expect = 7e-056
Identities = 124/333 (37%), Positives = 186/333 (55%), Gaps = 15/333 (4%)
Frame = +2
Query: 224 EPDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPR 403
E D+SV + G+K NPF + S PP T+ + +RAF++GWG ++ KT LD V NV+PR
Sbjct: 544 EVDISVDMCGVKFENPFGLASAPPTTSGPMCRRAFEQGWGFILTKTYGLDKDLVTNVSPR 603
Query: 404 YARLRTGSAKTDVIG-----WQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYT 568
R GS + G + NIELIS++ E L+ ++LK+++P +I+IASIM Y
Sbjct: 604 IVR---GSTSGPLYGPNQGSFMNIELISEKSCEYWLQCIRELKRDHPTKIVIASIMCVYN 660
Query: 569 KTGWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLEEVCGWINAKATVPV 748
K W EL + E+ G D LE+N SCPHGM E+ MG A GQ +++E+C W+ A +P
Sbjct: 661 KADWIELATKSEEAGADILELNLSCPHGMGEKGMGLACGQSPEIVKEICRWVRACVKIPF 720
Query: 749 WAKMTPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDLK-TLHPEPCVEGYSTPGGYS 925
+ KMTPNITD+ E AR + G G+ A NT+ S+M + P +T GG S
Sbjct: 721 FPKMTPNITDVREIARAARDGGASGVTATNTVSSLMHMKADGNAWPAIGSTKRTTYGGMS 780
Query: 926 YKAVRPIALAKVMNIAKMMRDEFSEKDCSLSGIGGVETGYDAAEFILLGSNTVQVCTGVM 1105
A+RPIA+ V +IA + D F + GG+E+ F++ G++ +QVC+ V
Sbjct: 781 GSAIRPIAMKAVSSIANEL-DGF-----PIMATGGIESAETGLGFLMAGASVLQVCSAVQ 834
Query: 1106 VHGYGHVKTLCAELRDFMKQHNFSTIEEFRGHS 1204
+ V C L+ + +++ + G S
Sbjct: 835 NQDFTVVDDYCTGLKALLYLSGAESLKNWDGQS 867
>sp|O89000|DPYD_RAT Dihydropyrimidine dehydrogenase [NADP+] OS=Rattus norvegicus
GN=Dpyd PE=2 SV=1
Length = 1025
Score = 218 bits (554), Expect = 1e-055
Identities = 122/332 (36%), Positives = 180/332 (54%), Gaps = 17/332 (5%)
Frame = +2
Query: 230 DLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPRYA 409
D+SV + GL+ PNPF + S P T+ +++RAF+ GWG + KT SLD V NV+PR
Sbjct: 532 DISVEMAGLRFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRII 591
Query: 410 RLRTGSAKTDVIG-----WQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYTKT 574
R G+ + G + NIELIS++ +LK ++PD ILIASIM Y K
Sbjct: 592 R---GTTSGPLYGPGQSSFLNIELISEKTAAYWCHSVTELKADFPDNILIASIMCSYNKN 648
Query: 575 GWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLEEVCGWINAKATVPVWA 754
W EL E +G DALE+N SCPHGM ER MG A GQD L+ +C W+ VP +A
Sbjct: 649 DWMELSKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQSVRVPFFA 708
Query: 755 KMTPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDLKTLHPEPCVEG--YSTPGGYSY 928
K+TPN+TDI AR + + G +G+ A NT+ +MG+ P P V +T GG S
Sbjct: 709 KLTPNVTDIVSIARAAKEGGADGVTATNTVSGLMGLKADG-SPWPSVGSGKRTTYGGVSG 767
Query: 929 KAVRPIALAKVMNIAKMMRDEFSEKDCSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMV 1108
+RPIAL V IA+ + + GG+++ +F+ G++ +QVC+ +
Sbjct: 768 TTIRPIALRAVTAIARAL------PGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQN 821
Query: 1109 HGYGHVKTLCAELRDFMKQHNFSTIEEFRGHS 1204
+ ++ C L+ + + + ++ G S
Sbjct: 822 QDFTVIEDYCTGLKALLYLKSIEELSDWDGQS 853
>sp|Q28943|DPYD_PIG Dihydropyrimidine dehydrogenase [NADP+] OS=Sus scrofa
GN=DPYD PE=1 SV=1
Length = 1025
Score = 218 bits (553), Expect = 2e-055
Identities = 121/331 (36%), Positives = 182/331 (54%), Gaps = 15/331 (4%)
Frame = +2
Query: 230 DLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPRYA 409
D+SV + GLK NPF + S P T+ ++++RAF+ GWG + KT SLD V NV+PR
Sbjct: 532 DISVEMAGLKFINPFGLASAAPTTSSSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIV 591
Query: 410 RLRTGSAKTDVIG-----WQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYTKT 574
R G+ + G + NIELIS++ + +LK ++PD I+IASIM Y K
Sbjct: 592 R---GTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKN 648
Query: 575 GWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLEEVCGWINAKATVPVWA 754
W EL + E +G DALE+N SCPHGM ER MG A GQD L+ +C W+ +P +A
Sbjct: 649 DWMELSRKAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFA 708
Query: 755 KMTPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDLK-TLHPEPCVEGYSTPGGYSYK 931
K+TPN+TDI AR + + G +G+ A NT+ +MG+ T P +T GG S
Sbjct: 709 KLTPNVTDIVSIARAAKEGGADGVTATNTVSGLMGLKADGTPWPAVGAGKRTTYGGVSGT 768
Query: 932 AVRPIALAKVMNIAKMMRDEFSEKDCSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMVH 1111
A+RPIAL V IA+ + + GG+++ +F+ G++ +QVC+ V
Sbjct: 769 AIRPIALRAVTTIARAL------PGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQ 822
Query: 1112 GYGHVKTLCAELRDFMKQHNFSTIEEFRGHS 1204
+ ++ C L+ + + ++ + G S
Sbjct: 823 DFTVIQDYCTGLKALLYLKSIEELQGWDGQS 853
>sp|Q55FT1|DPYD_DICDI Dihydropyrimidine dehydrogenase [NADP+] OS=Dictyostelium
discoideum GN=pyd1 PE=2 SV=1
Length = 1009
Score = 215 bits (547), Expect = 8e-055
Identities = 120/331 (36%), Positives = 183/331 (55%), Gaps = 15/331 (4%)
Frame = +2
Query: 230 DLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPRYA 409
D+SV + G+K PNPF + S P T+ +++R+F++GWG + KT SLD V NV+PR
Sbjct: 530 DISVEMCGMKFPNPFGLASATPATSAAMIRRSFEQGWGFAVTKTFSLDKDLVTNVSPRIV 589
Query: 410 RLRTGSAKTDVIG-----WQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYTKT 574
R G+ G + NIELIS++ K +LK+++PDRI+IASIM + K
Sbjct: 590 R---GTTSGHHFGPGQGAFLNIELISEKTCHYWCKAIGELKRDFPDRIVIASIMCGFNKE 646
Query: 575 GWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLEEVCGWINAKATVPVWA 754
W +L E +G D +E+N SCPHGM E+ MG A GQD L+ +C W+ A +P +A
Sbjct: 647 DWTQLAKMAEASGADGIELNLSCPHGMGEKGMGLACGQDTELVFHICQWVRAATRLPFFA 706
Query: 755 KMTPNITDITEPARVSLKSGCEGIAAINTIMSVMGI-DLKTLHPEPCVEGYSTPGGYSYK 931
K+TPN+T+I E A+ + G +G+ AINT+ +MG+ P E +T GG S
Sbjct: 707 KLTPNVTEIKEIAKAAHDGGADGVTAINTVSGLMGLKGDSNAWPAIGDEKRTTYGGVSGN 766
Query: 932 AVRPIALAKVMNIAKMMRDEFSEKDCSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMVH 1111
A RPIAL V +I K S D + GG ++ +F+ G++ VQ+C+ V
Sbjct: 767 ATRPIALRAVSSIRK------SLPDYPIMATGGADSADATIQFLHCGASVVQICSSVQNQ 820
Query: 1112 GYGHVKTLCAELRDFMKQHNFSTIEEFRGHS 1204
+ V+ L+ ++ + + ++ G S
Sbjct: 821 DFTVVQDYITGLKTYLYMQSREDLLQWDGQS 851
>sp|Q28007|DPYD_BOVIN Dihydropyrimidine dehydrogenase [NADP+] OS=Bos taurus
GN=DPYD PE=1 SV=1
Length = 1025
Score = 215 bits (546), Expect = 1e-054
Identities = 119/332 (35%), Positives = 183/332 (55%), Gaps = 17/332 (5%)
Frame = +2
Query: 230 DLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPRYA 409
D+SV + LK NPF + S P T+ ++++RAF+ GW + KT SLD V NV+PR
Sbjct: 532 DISVEMAALKFTNPFGLASATPTTSSSMIRRAFEAGWAFALTKTFSLDKDIVTNVSPRII 591
Query: 410 RLRTGSAKTDVIG-----WQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYTKT 574
R G+ + G + NIELIS++ + +LK ++PD I+IASIM Y +
Sbjct: 592 R---GTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNRN 648
Query: 575 GWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLEEVCGWINAKATVPVWA 754
W EL + E +G DALE+N SCPHGM ER MG A GQD L+ +C W+ +P +A
Sbjct: 649 DWMELSRKAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVRIPFFA 708
Query: 755 KMTPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDLKTLHPEPCV--EGYSTPGGYSY 928
K+TPN+TDI AR + + G G+ A NT+ +MG+ P P V E +T GG S
Sbjct: 709 KLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKADGT-PWPAVGREKRTTYGGVSG 767
Query: 929 KAVRPIALAKVMNIAKMMRDEFSEKDCSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMV 1108
A+RPIAL V IA+ + + + GG+++ +F+ G++ +QVC+ +
Sbjct: 768 TAIRPIALRAVTTIARAL------PEFPILATGGIDSAESGLQFLHGGASVLQVCSAIQN 821
Query: 1109 HGYGHVKTLCAELRDFMKQHNFSTIEEFRGHS 1204
+ ++ C L+ + + ++++ G S
Sbjct: 822 QDFTIIQDYCTGLKALLYLKSIEELQDWDGQS 853
>sp|Q6NYG8|DPYD_DANRE Dihydropyrimidine dehydrogenase [NADP+] OS=Danio rerio
GN=dpyd PE=2 SV=1
Length = 1022
Score = 214 bits (543), Expect = 2e-054
Identities = 115/332 (34%), Positives = 182/332 (54%), Gaps = 17/332 (5%)
Frame = +2
Query: 230 DLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPRYA 409
D+SV + G+K PNPF + S PP T+ +++RAF++GWG + KT LD V NV+PR
Sbjct: 532 DISVEMCGIKFPNPFGLASAPPTTSAAMIRRAFEQGWGFALTKTFGLDKDLVTNVSPRIV 591
Query: 410 RLRTGSAKTDVIG-----WQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYTKT 574
R G+ + G + NIELIS++ K +LK ++P I+IASIM Y +
Sbjct: 592 R---GTTSGHIFGPGQGSFLNIELISEKTAAYWCKSVAELKADFPKNIIIASIMCSYNQA 648
Query: 575 GWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLEEVCGWINAKATVPVWA 754
W EL +++ DALE+N SCPHGM ER MG A GQD L+ +C W+ ++P +A
Sbjct: 649 DWTELAKMAQESQADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRKATSIPFFA 708
Query: 755 KMTPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDLKTLHPEPCV--EGYSTPGGYSY 928
K+TPN+T+I + A + + G +G+ A NT+ +M + P P + +T GG S
Sbjct: 709 KLTPNVTNIVDIATAAYEGGADGVTATNTVSGLMALKADAT-PWPGIGRGARTTYGGVSG 767
Query: 929 KAVRPIALAKVMNIAKMMRDEFSEKDCSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMV 1108
A+RPIAL V IA+ + + GG+++ +F+ G++ +QVC+ V
Sbjct: 768 NAIRPIALRAVSAIARAL------PGFPILATGGIDSAESGLQFLHAGASVLQVCSAVQN 821
Query: 1109 HGYGHVKTLCAELRDFMKQHNFSTIEEFRGHS 1204
+ ++ C L+ + + + ++ G S
Sbjct: 822 QDFTVIEDYCLGLKALLYLKSIEELHDWDGQS 853
>sp|Q9V0Y6|PYRD_PYRAB Dihydroorotate dehydrogenase OS=Pyrococcus abyssi GN=pyrD
PE=3 SV=1
Length = 303
Score = 95 bits (235), Expect = 1e-018
Identities = 58/180 (32%), Positives = 98/180 (54%), Gaps = 12/180 (6%)
Frame = +2
Query: 671 GAAVGQDCALLEEVCGWINAKATVPVWAKMTPNITDITEPARVSLKSGCEGIAAINTIMS 850
G +GQ + EV + PV AK+TPN++DI E + K+G +G++AINT+ +
Sbjct: 135 GMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEKAGADGVSAINTVKA 194
Query: 851 VMGIDLKTLHPEPCVEGYSTPGGYSYKAVRPIALAKVMNIAKMMRDEFSEKDCSLSGIGG 1030
+ ID+ P + GGYS V+PIAL V ++A S D + GIGG
Sbjct: 195 I-AIDIYAKRPILS----NKFGGYSGPGVKPIALRAVYDLA-------SSLDIPVIGIGG 242
Query: 1031 VETGYDAAEFILLGSNTVQVCTGVMVHGYGHVKTLCAELRDFMKQHNFSTIEEFRGHSLQ 1210
+ T DA EF+L G++ +Q+ T V + G+ + + + ++K+ +S+++E G +L+
Sbjct: 243 ITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLALK 302
>sp|Q8U0P6|PYRD_PYRFU Dihydroorotate dehydrogenase OS=Pyrococcus furiosus
GN=pyrD PE=3 SV=1
Length = 300
Score = 94 bits (232), Expect = 3e-018
Identities = 57/176 (32%), Positives = 96/176 (54%), Gaps = 12/176 (6%)
Frame = +2
Query: 671 GAAVGQDCALLEEVCGWINAKATVPVWAKMTPNITDITEPARVSLKSGCEGIAAINTIMS 850
G +GQD + V + PV AK+TPN +DIT+ + K+ +G++AINT+ +
Sbjct: 132 GLEIGQDPENVYRVVKAVKDVTDKPVIAKLTPNTSDITKLGLAAEKAEADGVSAINTLKA 191
Query: 851 VMGIDLKTLHPEPCVEGYSTPGGYSYKAVRPIALAKVMNIAKMMRDEFSEKDCSLSGIGG 1030
+ ID+ P + GGYS ++PIAL V ++A S+ D + GIGG
Sbjct: 192 I-AIDIYAKRPILS----NKFGGYSGPGIKPIALRAVYDLA-------SKLDIPIIGIGG 239
Query: 1031 VETGYDAAEFILLGSNTVQVCTGVMVHGYGHVKTLCAELRDFMKQHNFSTIEEFRG 1198
+ T DA EF+L G++ VQ+ T V + G+ + + +R ++++ FS+++E G
Sbjct: 240 ITTWQDAVEFLLAGASAVQIGTAVYLKGFSVFREIAEGIRKYLEEEGFSSVKEIIG 295
>sp|Q5JHR7|PYRD_PYRKO Dihydroorotate dehydrogenase OS=Pyrococcus kodakaraensis
GN=pyrD PE=3 SV=1
Length = 302
Score = 89 bits (220), Expect = 6e-017
Identities = 55/180 (30%), Positives = 96/180 (53%), Gaps = 12/180 (6%)
Frame = +2
Query: 671 GAAVGQDCALLEEVCGWINAKATVPVWAKMTPNITDITEPARVSLKSGCEGIAAINTIMS 850
G +GQ + V + PV AK+TPNI DIT+ + +G + ++AINT+ +
Sbjct: 135 GMEIGQKPENVYAVVKAVKDATDKPVIAKLTPNIDDITKLGLAAENAGADAVSAINTLKA 194
Query: 851 VMGIDLKTLHPEPCVEGYSTPGGYSYKAVRPIALAKVMNIAKMMRDEFSEKDCSLSGIGG 1030
+ ID+ P + GGYS V+P+AL V ++A+ + D + GIGG
Sbjct: 195 I-AIDIYARKPILS----NKVGGYSGPGVKPVALRAVYDLARTL-------DIPVIGIGG 242
Query: 1031 VETGYDAAEFILLGSNTVQVCTGVMVHGYGHVKTLCAELRDFMKQHNFSTIEEFRGHSLQ 1210
+ T DA EF+L G++ +Q+ T V + G+ + + + ++++ FS++EE G +L+
Sbjct: 243 ITTWQDAVEFLLAGASALQIGTAVSLRGWKVFREINEGIERYLREEGFSSVEEIVGLALE 302
>sp|Q58070|PYRD_METJA Dihydroorotate dehydrogenase OS=Methanocaldococcus
jannaschii GN=pyrD PE=3 SV=1
Length = 306
Score = 81 bits (198), Expect = 2e-014
Identities = 62/212 (29%), Positives = 109/212 (51%), Gaps = 12/212 (5%)
Frame = +2
Query: 446 GWQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYTKTGWE--ELIDRVEQTGVD 619
G+ N + + ++ L+E ++++ E +R+ + I Y K E E+ ++E+ VD
Sbjct: 68 GFLNAMGLPNPGVDEYLEEIEKVRDEL-NRMDVRIIGSIYGKDEEEFAEVAKKMERY-VD 125
Query: 620 ALEINFSCPHGMPERRMGAAVGQDCALLEEVCGWINAKATVPVWAKMTPNITDITEPARV 799
+E+N SCPH + GA +GQ+ L +VC + +PV+AK+TPN+TDI E A+
Sbjct: 126 IIELNISCPHA---KGYGATIGQNPDLSYDVCKAVKKAVKIPVFAKLTPNVTDIIEIAQA 182
Query: 800 SLKSGCEGIAAINTIMSVMGIDLKTLHPEPCVEGYSTPGGYSYKAVRPIALAKVMNIAKM 979
+ +G +G+ AINT+ M ID++ P + GG S KA++ I + V ++ +
Sbjct: 183 VVDAGVDGLVAINTVRG-MAIDIRAKKPILA----NKFGGLSGKAIKSIGIKVVWDLYEN 237
Query: 980 MRDEFSEKDCSLSGIGGVETGYDAAEFILLGS 1075
+SG +E A + +GS
Sbjct: 238 FDVPIIGVGGIMSGEDAIEYMMAGASAVQIGS 269
>sp|Q8PW56|PYRD_METMA Dihydroorotate dehydrogenase OS=Methanosarcina mazei
GN=pyrD PE=3 SV=1
Length = 314
Score = 81 bits (198), Expect = 2e-014
Identities = 54/154 (35%), Positives = 83/154 (53%), Gaps = 9/154 (5%)
Frame = +2
Query: 509 QLKQEYPDRILIASIMEEYTKTGWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQ 688
+ +E D +IASI T + + E+ + + DA E+N SCPH GAA+G
Sbjct: 96 EFAKENSDAPVIASIFGG-TPSEFAEVAEGLLPAKPDAFELNVSCPHA---EGYGAAIGS 151
Query: 689 DCALLEEVCGWINAKATVPVWAKMTPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDL 868
+ L+E V + VPVW K+TPN+ DIT + G + + AINT+ M ID+
Sbjct: 152 NPCLVEAVTAAVKDVVNVPVWVKLTPNVADITCIGNAAESGGADAVVAINTVKG-MAIDI 210
Query: 869 KTLHPEPCVEGYSTPGGYSYKAVRPIALAKVMNI 970
++ +P V G + GG S KAV+P+A+ V ++
Sbjct: 211 ESGYP---VLG-NRSGGLSGKAVKPVAVKCVYDL 240
>sp|Q8TT55|PYRD_METAC Dihydroorotate dehydrogenase OS=Methanosarcina acetivorans
GN=pyrD PE=3 SV=1
Length = 311
Score = 80 bits (195), Expect = 5e-014
Identities = 48/118 (40%), Positives = 68/118 (57%), Gaps = 8/118 (6%)
Frame = +2
Query: 617 DALEINFSCPHGMPERRMGAAVGQDCALLEEVCGWINAKATVPVWAKMTPNITDITEPAR 796
DALE+N SCPH GAAVG + L+E V + VPVW K+TPN+ DIT
Sbjct: 128 DALELNVSCPHA---EGYGAAVGSNPCLVEAVTAAVKDVVNVPVWVKLTPNVADITCIGN 184
Query: 797 VSLKSGCEGIAAINTIMSVMGIDLKTLHPEPCVEGYSTPGGYSYKAVRPIALAKVMNI 970
+ G + + AINT+ M ID+++ +P V G + GG S KAV+P+A+ V ++
Sbjct: 185 AAESGGADAVVAINTVKG-MAIDIESGYP---VLG-NRSGGLSGKAVKPVAVKCVYDL 237
>sp|Q6A912|PYRD_PROAC Dihydroorotate dehydrogenase OS=Propionibacterium acnes
GN=pyrD PE=3 SV=1
Length = 307
Score = 74 bits (181), Expect = 2e-012
Identities = 49/165 (29%), Positives = 87/165 (52%), Gaps = 10/165 (6%)
Frame = +2
Query: 491 MLKEFKQLKQEYPDRILIASIMEEYTKTGWEELIDRVEQT-GVDALEINFSCPHGMPERR 667
M ++ L + +PD +IA++ YT + + + + V A+EIN SCP+ +R
Sbjct: 82 MAEKLPWLAEHFPDLPIIANV-AGYTTEDYVRVCEVISTAPNVAAVEINISCPN---VKR 137
Query: 668 MGAAVGQDCALLEEVCGWINAKATVPVWAKMTPNITDITEPARVSLKSGCEGIAAINTIM 847
G G + ++ + A A+VPV+ K++PN+TDITE AR + +G +G+ INT+
Sbjct: 138 GGITFGTNVTAAHDLTQAVVAAASVPVYVKLSPNVTDITEIARATADAGADGLTLINTL- 196
Query: 848 SVMGIDLKTLHPEPCVEGYSTPGGYSYKAVRPIALAKVMNIAKMM 982
G+ + P + + GG S AV PIA+ + + +++
Sbjct: 197 --TGMRINLARRTPVIA--NATGGLSGPAVLPIAVRMIDAVTRVV 237
>sp|Q6V3X0|PYRD_SACCA Dihydroorotate dehydrogenase OS=Saccharomyces castellii
GN=URA1 PE=3 SV=1
Length = 314
Score = 55 bits (131), Expect = 1e-006
Identities = 39/126 (30%), Positives = 63/126 (50%), Gaps = 6/126 (4%)
Frame = +2
Query: 824 IAAINTIMSV-MGIDLKTLHPEPCVEGYSTPGGYSYKAVRPIALAKVMNIAKMMRDEFSE 1000
+A +N+I SV G+ + V+ + GG + V+P ALA V +
Sbjct: 189 LAYVNSINSVGNGLYIDVDKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLNPSI-- 246
Query: 1001 KDCSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMVHGYGHVKTLCAELRDFMKQHNFST 1180
+ G GG+ TG D E +L G++ VQ+ T ++ G + L EL++ M + ++T
Sbjct: 247 ---KIVGTGGIRTGKDVFEHLLCGASMVQIGTELVKEGVPIFERLERELKEVMDKKGYTT 303
Query: 1181 IEEFRG 1198
IEEFRG
Sbjct: 304 IEEFRG 309
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,771,599,260
Number of Sequences: 518415
Number of Extensions: 58771599260
Number of Successful Extensions: 389091298
Number of sequences better than 0.0: 0
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