BLASTX 7.6.2
Query= UN14586 /QuerySize=1502
(1501 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UQ80|PA2G4_HUMAN Proliferation-associated protein 2G4 OS=Ho... 127 2e-028
sp|P50580|PA2G4_MOUSE Proliferation-associated protein 2G4 OS=Mu... 126 6e-028
sp|Q1ZXG4|PRLA_DICDI Proliferation-associated protein A OS=Dicty... 122 8e-027
sp|Q09184|CDB4_SCHPO Curved DNA-binding protein OS=Schizosacchar... 97 4e-019
sp|Q3ZC89|AMPM2_BOVIN Methionine aminopeptidase 2 OS=Bos taurus ... 72 9e-012
sp|P50579|AMPM2_HUMAN Methionine aminopeptidase 2 OS=Homo sapien... 72 9e-012
sp|O08663|AMPM2_MOUSE Methionine aminopeptidase 2 OS=Mus musculu... 72 9e-012
sp|P38062|AMPM2_RAT Methionine aminopeptidase 2 OS=Rattus norveg... 72 9e-012
sp|Q9FV49|AMP2A_ARATH Methionine aminopeptidase 2A OS=Arabidopsi... 67 2e-010
sp|Q56Y85|AMP2B_ARATH Methionine aminopeptidase 2B OS=Arabidopsi... 65 1e-009
sp|O60180|ARX1_SCHPO Probable metalloprotease arx1 OS=Schizosacc... 61 2e-008
sp|P56218|AMPM_PYRFU Methionine aminopeptidase OS=Pyrococcus fur... 59 6e-008
sp|O28438|AMPM_ARCFU Methionine aminopeptidase OS=Archaeoglobus ... 59 8e-008
sp|O58362|AMPM_PYRHO Methionine aminopeptidase OS=Pyrococcus hor... 59 8e-008
>sp|Q9UQ80|PA2G4_HUMAN Proliferation-associated protein 2G4 OS=Homo sapiens
GN=PA2G4 PE=1 SV=3
Length = 394
Score = 127 bits (318), Expect = 2e-028
Identities = 69/141 (48%), Positives = 88/141 (62%), Gaps = 3/141 (2%)
Frame = +3
Query: 816 QKDAAVNYQLKMKASRFIFSEIKEKFPHMPFTARSLE-EKRARLGLVECVNHGHLQPYPV 992
++D + Y LKMK SR FSE++ +F MPFT R+ E EK+AR+G+VEC H LQP+ V
Sbjct: 248 KRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNV 307
Query: 993 LYEKPGDFVAQIKFTVLLMPNGSDRITSHTLQE--LQPTKTIDDPEIKGWLALGIKKKKG 1166
LYEK G+FVAQ KFTVLLMPNG RITS + + + D E+K L +K
Sbjct: 308 LYEKEGEFVAQFKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQ 367
Query: 1167 GGKKKKAKKAGETSTEAEPME 1229
KKKKA K E +T E +E
Sbjct: 368 KKKKKKASKTAENATSGETLE 388
Score = 125 bits (312), Expect = 1e-027
Identities = 59/122 (48%), Positives = 85/122 (69%), Gaps = 2/122 (1%)
Frame = +3
Query: 99 ERDEKELDITSSEVVTKYKSAAEIVNKALLGVLAECKPKAKIVDICEKGDSFIKEQAGSM 278
E +++E I VVTKYK +I N+ L ++ ++ +CEKGD+ I E+ G +
Sbjct: 4 EDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKI 63
Query: 279 YKNVKKKIDRGVAFPTCVSVNNTVCHFSPLASDET-VLEEGDMVKIDMGCHIDGFIALVA 455
+K +K++ +G+AFPT +SVNN VCHFSPL SD+ +L+EGD+VKID+G H+DGFIA VA
Sbjct: 64 FKK-EKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVA 122
Query: 456 HT 461
HT
Sbjct: 123 HT 124
Score = 117 bits (292), Expect = 3e-025
Identities = 62/128 (48%), Positives = 91/128 (71%), Gaps = 6/128 (4%)
Frame = +1
Query: 454 HTHVI---REGPITGRKADVIAAANTAAEVALRLVRPGKKNHAVTEAIQKVAEAYDCKIV 624
HT V+ + +TGRKADVI AA+ AE ALRLV+PG +N VTEA KVA +++C +
Sbjct: 123 HTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPI 182
Query: 625 EGVISHQMKQNVIDASKSLLSVSTPETRVD--DAEFEENEVYAIDIVASTGDGKPKLLDE 798
EG++SHQ+KQ+VID K+++ T + + D AEFE +EVYA+D++ S+G+GK K +
Sbjct: 183 EGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQ 242
Query: 799 KQTTIYRK 822
+ TTIY++
Sbjct: 243 R-TTIYKR 249
>sp|P50580|PA2G4_MOUSE Proliferation-associated protein 2G4 OS=Mus musculus
GN=Pa2g4 PE=1 SV=3
Length = 394
Score = 126 bits (315), Expect = 6e-028
Identities = 69/141 (48%), Positives = 88/141 (62%), Gaps = 3/141 (2%)
Frame = +3
Query: 816 QKDAAVNYQLKMKASRFIFSEIKEKFPHMPFTARSLE-EKRARLGLVECVNHGHLQPYPV 992
++D + Y LKMK SR FSE++ +F MPFT R+ E EK+AR+G+VEC H LQP+ V
Sbjct: 248 KRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNV 307
Query: 993 LYEKPGDFVAQIKFTVLLMPNGSDRITSHTLQE--LQPTKTIDDPEIKGWLALGIKKKKG 1166
LYEK G+FVAQ KFTVLLMPNG RITS + + + D E+K L +K
Sbjct: 308 LYEKEGEFVAQFKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQ 367
Query: 1167 GGKKKKAKKAGETSTEAEPME 1229
KKKKA K E +T E +E
Sbjct: 368 KKKKKKASKTVENATSGETLE 388
Score = 125 bits (312), Expect = 1e-027
Identities = 59/122 (48%), Positives = 85/122 (69%), Gaps = 2/122 (1%)
Frame = +3
Query: 99 ERDEKELDITSSEVVTKYKSAAEIVNKALLGVLAECKPKAKIVDICEKGDSFIKEQAGSM 278
E +++E I VVTKYK +I N+ L ++ ++ +CEKGD+ I E+ G +
Sbjct: 4 EDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKI 63
Query: 279 YKNVKKKIDRGVAFPTCVSVNNTVCHFSPLASDET-VLEEGDMVKIDMGCHIDGFIALVA 455
+K +K++ +G+AFPT +SVNN VCHFSPL SD+ +L+EGD+VKID+G H+DGFIA VA
Sbjct: 64 FKK-EKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVA 122
Query: 456 HT 461
HT
Sbjct: 123 HT 124
Score = 117 bits (293), Expect = 2e-025
Identities = 63/128 (49%), Positives = 91/128 (71%), Gaps = 6/128 (4%)
Frame = +1
Query: 454 HTHVI---REGPITGRKADVIAAANTAAEVALRLVRPGKKNHAVTEAIQKVAEAYDCKIV 624
HT VI + +TGRKADVI AA+ AE ALRLV+PG +N VTEA KVA +++C +
Sbjct: 123 HTFVIGVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPI 182
Query: 625 EGVISHQMKQNVIDASKSLLSVSTPETRVD--DAEFEENEVYAIDIVASTGDGKPKLLDE 798
EG++SHQ+KQ+VID K+++ T + + D AEFE +EVYA+D++ S+G+GK K +
Sbjct: 183 EGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQ 242
Query: 799 KQTTIYRK 822
+ TTIY++
Sbjct: 243 R-TTIYKR 249
>sp|Q1ZXG4|PRLA_DICDI Proliferation-associated protein A OS=Dictyostelium
discoideum GN=prlA PE=2 SV=1
Length = 385
Score = 122 bits (305), Expect = 8e-027
Identities = 60/131 (45%), Positives = 89/131 (67%), Gaps = 6/131 (4%)
Frame = +3
Query: 84 MSSDDERDEKEL-----DITSSEVVTKYKSAAEIVNKALLGVLAECKPKAKIVDICEKGD 248
MS+ D+ ++E D+++ VV Y +A I N A+ V+++C A +VDIC+ GD
Sbjct: 1 MSNKDQEIKEEAPVAIEDLSNPVVVDSYNAAGIIANNAIKHVISKCVVGALVVDICQYGD 60
Query: 249 SFIKEQAGSMYKNVKKKIDRGVAFPTCVSVNNTVCHFSPLASDETVLEEGDMVKIDMGCH 428
FI+ +A + +K +++G+AFPTCVSVNN V HFSPL + L++GD+VKID+GCH
Sbjct: 61 DFIEAEAAKTFTK-RKNLEKGIAFPTCVSVNNCVGHFSPLKGNTRTLKQGDVVKIDLGCH 119
Query: 429 IDGFIALVAHT 461
IDG+IA+ AHT
Sbjct: 120 IDGYIAVGAHT 130
Score = 107 bits (267), Expect = 2e-022
Identities = 51/114 (44%), Positives = 79/114 (69%), Gaps = 1/114 (0%)
Frame = +1
Query: 481 ITGRKADVIAAANTAAEVALRLVRPGKKNHAVTEAIQKVAEAYDCKIVEGVISHQMKQNV 660
+TG+ AD I AA+ A E ALR++RPGK ++ VT+ I+K+++ Y V G++SH++K+ +
Sbjct: 141 MTGKVADAICAAHYALEAALRMIRPGKTSNEVTQVIEKISDMYGVTSVSGILSHELKRFI 200
Query: 661 IDASKSLLSVSTPETRVDDAEFEENEVYAIDIVASTGDGKPKLLDEKQTTIYRK 822
ID K + S + P ++ EF+ENEVY IDIV STG+GK + + + TIYR+
Sbjct: 201 IDGEKVIFSKNEPSQKIQTYEFQENEVYCIDIVMSTGEGKAR-EEADRPTIYRR 253
Score = 82 bits (201), Expect = 9e-015
Identities = 49/130 (37%), Positives = 76/130 (58%), Gaps = 7/130 (5%)
Frame = +3
Query: 837 YQLKMKASRFIFSEIKEKFPHMPFTARSLEEKRARLGLVECVNHGHLQPYPVLYEKPGDF 1016
Y+LK KASR +I +++ +PF R+ +EK ++LGLVE V H L YPVL+++ G
Sbjct: 259 YKLKSKASRDFKDQIVKRYSALPFPLRNFDEKVSKLGLVELVEHQVLAAYPVLFDRSGCE 318
Query: 1017 VAQIKFTVLLMPNGSDRI--TSHTLQELQPTKTIDDPEIKGWLALGIKKKKGGGKKKKAK 1190
V Q K TVL++PNG+ ++ T L ++ ++ D IK +A +K KK AK
Sbjct: 319 VVQFKTTVLVLPNGNHKLIGTEFPLPFVRSEFSVTDDAIKALIASPLKI-----NKKAAK 373
Query: 1191 KAGETSTEAE 1220
KA T+ + +
Sbjct: 374 KASATTIDVK 383
>sp|Q09184|CDB4_SCHPO Curved DNA-binding protein OS=Schizosaccharomyces pombe
GN=cdb4 PE=1 SV=1
Length = 381
Score = 97 bits (239), Expect = 4e-019
Identities = 50/124 (40%), Positives = 73/124 (58%), Gaps = 2/124 (1%)
Frame = +1
Query: 457 THVIREGPITGRKADVIAAANTAAEVALRLVRPGKKNHAVTEAIQKVAEAYDCKIVEGVI 636
T V+ E P+TG ADVIAAA+ A + A R ++PG N VT+ + K+A +Y CK V G++
Sbjct: 129 TTVVSEEPVTGPAADVIAAASAALKAAQRTIKPGNTNWQVTDIVDKIATSYGCKPVAGML 188
Query: 637 SHQMKQNVIDASKSLL--SVSTPETRVDDAEFEENEVYAIDIVASTGDGKPKLLDEKQTT 810
SHQ ++ VID K ++ + + +D FEE EVY +DI+ ST + T
Sbjct: 189 SHQQEREVIDGKKQVILNPSDSQRSEMDTFTFEEGEVYGVDILVSTSPSGKVKRSDIATR 248
Query: 811 IYRK 822
IY+K
Sbjct: 249 IYKK 252
>sp|Q3ZC89|AMPM2_BOVIN Methionine aminopeptidase 2 OS=Bos taurus GN=METAP2 PE=2
SV=1
Length = 477
Score = 72 bits (175), Expect = 9e-012
Identities = 43/120 (35%), Positives = 66/120 (55%), Gaps = 8/120 (6%)
Frame = +3
Query: 105 DEKELDITSSEVVTKYKSAAEIVNKALLGVLAECKPKAKIVDICEKGDSFIKEQAGSMYK 284
++K LD S E+ ++ AAE + V++ KP +++ICEK + + K
Sbjct: 153 EKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKMEDCSR-------K 205
Query: 285 NVKKK-IDRGVAFPTCVSVNNTVCHFSPLASDETVLEEGDMVKIDMGCHIDGFIALVAHT 461
+K+ ++ G+AFPT S+NN H++P A D TVL+ D+ KID G HI G I A T
Sbjct: 206 LIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFT 265
>sp|P50579|AMPM2_HUMAN Methionine aminopeptidase 2 OS=Homo sapiens GN=METAP2
PE=1 SV=1
Length = 478
Score = 72 bits (175), Expect = 9e-012
Identities = 42/119 (35%), Positives = 67/119 (56%), Gaps = 6/119 (5%)
Frame = +3
Query: 105 DEKELDITSSEVVTKYKSAAEIVNKALLGVLAECKPKAKIVDICEKGDSFIKEQAGSMYK 284
++K LD S E+ ++ AAE + V++ KP +++ICEK +++ + + K
Sbjct: 154 EKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEK----LEDCSRKLIK 209
Query: 285 NVKKKIDRGVAFPTCVSVNNTVCHFSPLASDETVLEEGDMVKIDMGCHIDGFIALVAHT 461
+ ++ G+AFPT S+NN H++P A D TVL+ D+ KID G HI G I A T
Sbjct: 210 --ENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFT 266
>sp|O08663|AMPM2_MOUSE Methionine aminopeptidase 2 OS=Mus musculus GN=Metap2
PE=1 SV=1
Length = 478
Score = 72 bits (175), Expect = 9e-012
Identities = 42/119 (35%), Positives = 67/119 (56%), Gaps = 6/119 (5%)
Frame = +3
Query: 105 DEKELDITSSEVVTKYKSAAEIVNKALLGVLAECKPKAKIVDICEKGDSFIKEQAGSMYK 284
++K LD S E+ ++ AAE + V++ KP +++ICEK +++ + + K
Sbjct: 154 EKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEK----LEDCSRKLIK 209
Query: 285 NVKKKIDRGVAFPTCVSVNNTVCHFSPLASDETVLEEGDMVKIDMGCHIDGFIALVAHT 461
+ ++ G+AFPT S+NN H++P A D TVL+ D+ KID G HI G I A T
Sbjct: 210 --ENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFT 266
>sp|P38062|AMPM2_RAT Methionine aminopeptidase 2 OS=Rattus norvegicus GN=Metap2
PE=2 SV=2
Length = 478
Score = 72 bits (175), Expect = 9e-012
Identities = 42/119 (35%), Positives = 67/119 (56%), Gaps = 6/119 (5%)
Frame = +3
Query: 105 DEKELDITSSEVVTKYKSAAEIVNKALLGVLAECKPKAKIVDICEKGDSFIKEQAGSMYK 284
++K LD S E+ ++ AAE + V++ KP +++ICEK +++ + + K
Sbjct: 154 EKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEK----LEDCSRKLIK 209
Query: 285 NVKKKIDRGVAFPTCVSVNNTVCHFSPLASDETVLEEGDMVKIDMGCHIDGFIALVAHT 461
+ ++ G+AFPT S+NN H++P A D TVL+ D+ KID G HI G I A T
Sbjct: 210 --ENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFT 266
>sp|Q9FV49|AMP2A_ARATH Methionine aminopeptidase 2A OS=Arabidopsis thaliana
GN=MAP2A PE=2 SV=2
Length = 441
Score = 67 bits (163), Expect = 2e-010
Identities = 34/119 (28%), Positives = 65/119 (54%), Gaps = 6/119 (5%)
Frame = +3
Query: 105 DEKELDITSSEVVTKYKSAAEIVNKALLGVLAECKPKAKIVDICEKGDSFIKEQAGSMYK 284
+++E++ + + AAE+ + + + KP ++D+CE ++ +++
Sbjct: 117 EKREMERLQKPIYNSLRQAAEVHRQVRKYMRSILKPGMLMIDLCETLENTVRKLIS---- 172
Query: 285 NVKKKIDRGVAFPTCVSVNNTVCHFSPLASDETVLEEGDMVKIDMGCHIDGFIALVAHT 461
+ + G+AFPT S+NN H++P + D+TVL+ D++K+D G HIDG I A T
Sbjct: 173 --ENGLQAGIAFPTGCSLNNVAAHWTPNSGDKTVLQYDDVMKLDFGTHIDGHIVDSAFT 229
>sp|Q56Y85|AMP2B_ARATH Methionine aminopeptidase 2B OS=Arabidopsis thaliana
GN=MAP2B PE=2 SV=2
Length = 439
Score = 65 bits (157), Expect = 1e-009
Identities = 39/135 (28%), Positives = 68/135 (50%), Gaps = 11/135 (8%)
Frame = +3
Query: 72 ELSEMSSDD-----ERDEKELDITSSEVVTKYKSAAEIVNKALLGVLAECKPKAKIVDIC 236
E+ E D+ +++EL+ + + AAE+ + V + KP + DIC
Sbjct: 99 EIQEYKDDNLWRTTSEEKRELERFEKPIYNSVRRAAEVHRQVRKYVRSIVKPGMLMTDIC 158
Query: 237 EKGDSFIKEQAGSMYKNVKKKIDRGVAFPTCVSVNNTVCHFSPLASDETVLEEGDMVKID 416
E ++ +++ + + G+AFPT S+N H++P + D+TVL+ D++K+D
Sbjct: 159 ETLENTVRKLIS------ENGLQAGIAFPTGCSLNWVAAHWTPNSGDKTVLQYDDVMKLD 212
Query: 417 MGCHIDGFIALVAHT 461
G HIDG I A T
Sbjct: 213 FGTHIDGHIIDCAFT 227
>sp|O60180|ARX1_SCHPO Probable metalloprotease arx1 OS=Schizosaccharomyces pombe
GN=arx1 PE=2 SV=1
Length = 417
Score = 61 bits (147), Expect = 2e-008
Identities = 35/88 (39%), Positives = 49/88 (55%)
Frame = +3
Query: 822 DAAVNYQLKMKASRFIFSEIKEKFPHMPFTARSLEEKRARLGLVECVNHGHLQPYPVLYE 1001
D V+Y LK+KASR + SEIK++ PF SL +R LGL E + L P PVL
Sbjct: 293 DVNVSYMLKLKASRSLLSEIKKEKSVFPFHFGSLSSERNLLGLRELTDRHILVPMPVLIS 352
Query: 1002 KPGDFVAQIKFTVLLMPNGSDRITSHTL 1085
P + +A+ + TV+ PN S + T+
Sbjct: 353 SPSNVIAREELTVITQPNPSSDLLCLTV 380
>sp|P56218|AMPM_PYRFU Methionine aminopeptidase OS=Pyrococcus furiosus GN=map
PE=1 SV=1
Length = 295
Score = 59 bits (142), Expect = 6e-008
Identities = 34/85 (40%), Positives = 49/85 (57%), Gaps = 2/85 (2%)
Frame = +3
Query: 207 KPKAKIVDICEKGDSFIKEQAGSMYKNVKKKIDRGVAFPTCVSVNNTVCHFSPLASDETV 386
K + K + + G + E A S+ K + ++ AFP +S+N H++P D TV
Sbjct: 15 KVREKAIKLARPG-MLLLELAESIEKMI-MELGGKPAFPVNLSINEIAAHYTPYKGDTTV 72
Query: 387 LEEGDMVKIDMGCHIDGFIALVAHT 461
L+EGD +KID+G HIDGFIA A T
Sbjct: 73 LKEGDYLKIDVGVHIDGFIADTAVT 97
>sp|O28438|AMPM_ARCFU Methionine aminopeptidase OS=Archaeoglobus fulgidus GN=map
PE=3 SV=1
Length = 291
Score = 59 bits (141), Expect = 8e-008
Identities = 25/49 (51%), Positives = 36/49 (73%)
Frame = +3
Query: 315 AFPTCVSVNNTVCHFSPLASDETVLEEGDMVKIDMGCHIDGFIALVAHT 461
AFP +S+N+ HF+P +DE +EGD+VK+D+G HIDG+IA +A T
Sbjct: 52 AFPANISINSDAAHFTPKKNDERTFKEGDVVKLDVGAHIDGYIADMAVT 100
>sp|O58362|AMPM_PYRHO Methionine aminopeptidase OS=Pyrococcus horikoshii GN=map
PE=3 SV=1
Length = 295
Score = 59 bits (141), Expect = 8e-008
Identities = 26/49 (53%), Positives = 35/49 (71%)
Frame = +3
Query: 315 AFPTCVSVNNTVCHFSPLASDETVLEEGDMVKIDMGCHIDGFIALVAHT 461
AFP +S+N H++P D+TVL+EGD +KID+G HIDG+IA A T
Sbjct: 49 AFPANLSLNEVAAHYTPYKGDQTVLKEGDYLKIDLGVHIDGYIADTAVT 97
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,771,599,260
Number of Sequences: 518415
Number of Extensions: 58771599260
Number of Successful Extensions: 389091298
Number of sequences better than 0.0: 0
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